# Quebec Route 143

Route 143 is a north/south highway on the south shore of the Saint Lawrence River, in the Centre-du-Québec and Estrie regions of Quebec. Until the mid-1970s when the province decided to renumber all highways other than autoroutes, it was known as Route/Highway 5. Its northern terminus is in Saint-François-du-Lac, at the junction of Route 132, and the southern terminus is in Stanstead, at the border with Vermont where the road continues past the Derby Line–Stanstead Border Crossing as U.S. Route 5 through Derby Line to New Haven, Connecticut.
Since Autoroute 55 closely parallels Route 143 for most of its length, much commercial traffic chooses the former. However, it is a very busy route and takes much traffic from the border to the Sherbrooke local area. Route 143 closely follows the Saint-François River between Sherbrooke and Ulverton.
The road is often in notoriously poor condition, since its original cement was laid directly on a gravel road in the mid-1920s. It has been extensively resurfaced to the point the pavement is now more than three feet thick in places, but it heaves extensively at every spring thaw.

## Municipalities along Route 143

* Stanstead
* Stanstead-Est
* Hatley
* Waterville
* Sherbrooke - (Lennoxville / Sherbrooke / Bromptonville)
* Val-Joli
* Windsor
* Cleveland
* Richmond
* Ulverton
* L'Avenir
* Drummondville - (Saint-Nicéphore / Drummondville / Saint-Majorique-de-Grantham)
* Saint-Bonaventure
* Saint-Pie-de-Guire
* Saint-François-du-Lac

## Major intersections

| RCM or ET | Municipality | Km | Junction | Notes |
| Southern terminus of Route 143 |||||
| Memphrémagog | Stanstead | 0.0 | US 5 south | 5 SOUTH: to Derby Line, Vermont |
| Memphrémagog | Stanstead | 0.2 0.3 | R-247 | 247 NORTH: to Ogden 247 SOUTH: to A-55 |
| Memphrémagog | Stanstead | 2.4 2.8 | A-55 | 55 SOUTH: to I-91 in Derby Line, Vermont 55 NORTH: to Stanstead-East |
| Memphrémagog | Stanstead-East | 17.6 | R-141 | 141 NORTH: to Ayer's Cliff 141 SOUTH: to Barnston-Ouest |
| Memphrémagog | Hatley | 22.0 | R-208 (Overlap 0.6 km) | 208 WEST: to Ayer's Cliff 208 EAST: to Compton |
| Coaticook | Waterville | 36.2 | Rue Gosselin | EAST: to Waterville |
| Coaticook | Waterville | 40.8 | R-108 (Overlap 6.0 km) | 108 WEST: to Hatley Township |
| Coaticook | Waterville | 44.1 | R-147 | 147 SOUTH: to Compton |
| Sherbrooke | Lennoxville | 46.8 | R-108 (Overlap 6.0 km) | 108 EAST: to Eaton |
| Sherbrooke | Sherbrooke | 50.8 | R-216 | 216 WEST: to Magog 216 EAST: to Stoke |
| Sherbrooke | Sherbrooke | 51.9 | R-112 | 112 WEST: to Rock Forest (Sherbrooke) 112 EAST: to Fleurimont (Sherbrooke) |
| Sherbrooke | Bromptonville | 58.3 | R-222 (East end) | 222 WEST: to Saint-Denis-de-Brompton |
| Sherbrooke | Bromptonville | 61.8 | Rue Laval | WEST: to A-55 |
| Le Val-Saint-François | Windsor | 74.7 | R-249 | 249 SOUTH: to Saint-François-Xavier-de-Brompton 249 NORTH: to Val-Joli |
| Le Val-Saint-François | Richmond | 90.2 | R-116 (Overlap 1.9 km) | 116 EAST: to Cleveland |
| Le Val-Saint-François | Richmond | 91.3 | R-243 (Overlap 1.1 km) | 243 NORTH: to Saint-Félix-de-Kingsey |
| Le Val-Saint-François | Richmond | 92.1 | R-116 (Overlap 1.9 km) | 116 WEST: to Durham-Sud |
| Le Val-Saint-François | Richmond | 92.4 | R-243 (Overlap 1.1 km) | 243 SOUTH: to Melbourne |
| Drummond | Saint-Nicéphore | 120.6 | R-139 (North end) | 139 SOUTH: to Wickham |
| Drummond | Drummondville | 129.2 129.5 | R-122 (Overlap 0.3 km) | 122 EAST: to Saint-Charles-de-Drummond (Drummondville) 122 WEST: to Saint-Germain-de-Grantham (Drummondville) |
| Drummond | Drummondville | 131.9 132.2 | A-20 (TCH) | 20 EAST: to Saint-Cyrille-de-Wendover 20 WEST: to Saint-Eugène |
| Drummond | Saint-Bonaventure | 148.8 | R-224 (East end) | 224 WEST: to Saint-Guillaume |
| Nicolet-Yamaska | Saint-François-du-Lac | 165.8 | R-132 | 132 WEST: to Saint-Gérard-Majella 132 EAST: to Pierreville |
| Northern terminus of Route 143 |||||