# List of Family Guy guest stars

Family Guy is an American adult animated sitcom created by Seth MacFarlane for the Fox Broadcasting Company. The series centers on the Griffins, a family consisting of parents Peter and Lois; their children Meg, Chris, and Stewie; and their anthropomorphic pet dog Brian. The show is set in the fictional city of Quahog, Rhode Island, and exhibits much of its humor in the form of cutaway gags that often lampoon American culture. Along with its core voice actors, episodes make frequent use of guest stars.
Guest stars who have lent their voices to the show come from a wide range of occupations including musicians, actors, athletes, politicians and more. Some have only made a single appearance, while others, like James Woods, have gone on to become recurring fan favorites. Over the years, the show has become notable for featuring stars reprising their famous roles in animated form. In the episode "Lois Comes Out of Her Shell", for example, Johnny Depp reprised his iconic role as Edward Scissorhands. On the other hand, episodes have also given guests the opportunity to play caricatures of themselves, like "Not All Dogs Go to Heaven" which featured the main cast of Star Trek: The Next Generation, including Patrick Stewart, Jonathan Frakes, Brent Spiner, LeVar Burton, Gates McFadden, Michael Dorn, Wil Wheaton, Marina Sirtis, and even Denise Crosby (season 1 as Tasha Yar), playing themselves headed to a Star Trek convention.

## Season 1

| Name | Role(s) | Episode |
| Erik Estrada | Ponch | "I Never Met the Dead Man" Episode 2 |
| Frank Welker | Fred Jones | "I Never Met the Dead Man" Episode 2 |
| John O'Hurley | Cult leader | "Chitty Chitty Death Bang" Episode 3 |
| Waylon Jennings | Himself | "Chitty Chitty Death Bang" Episode 3 |
| Alex Rocco | Soccer parent | "Mind Over Murder" Episode 4 |
| Leslie Uggams | Herself | "Mind Over Murder" Episode 4 |
| Michelle Kwan | Herself | "A Hero Sits Next Door" Episode 5 |
| Bobby Slayton | Leonard Cornfeathers | "The Son Also Draws" Episode 6 |
| Mary Scheer | Ann Landers Mary Mother | "Brian: Portrait of a Dog" Episode 7 |
| Dick Van Patten | Tom Bradford | "Brian: Portrait of a Dog" Episode 7 |
$^†$Uncredited

## Season 2

| Name | Role(s) | Episode |
| Fairuza Balk | Connie D'Amico | "Peter, Peter, Caviar Eater" Episode 1 |
| Gregory Jbara | Jonathan | "Peter, Peter, Caviar Eater" Episode 1 |
| Robin Leach | Himself | "Peter, Peter, Caviar Eater" Episode 1 |
| Charles Durning | Francis Griffin | "Holy Crap" Episode 2 |
| Olivia Hack | Cindy Brady | "Holy Crap" Episode 2 |
| Dwight Schultz | The Pope | "Holy Crap" Episode 2 |
| Florence Stanley | Thelma Griffin | "Holy Crap" Episode 2 |
| Patrick Duffy | Bobby Ewing | "Da Boom" Episode 3 |
| Jack Perkins | Himself | "Da Boom" Episode 3 |
| Victoria Principal | Pamela Ewing | "Da Boom" Episode 3 |
| Will Sasso | Randy Newman | "Da Boom" Episode 3 |
| Sam Waterston | Dr. Kaplan | "Brian in Love" Episode 4 |
| Debra Wilson | Mrs. Kraner Sandy Belford | "Love Thy Trophy" Episode 5 |
| Karen Black | Herself | "Death Is a Bitch" Episode 6 |
| Norm Macdonald | Death | "Death Is a Bitch" Episode 6 |
| Candice Bergen | Gloria Ironbachs | "I Am Peter, Hear Me Roar" Episode 8 |
| Faith Ford | Sarah Bennett, Corky Sherwood | "I Am Peter, Hear Me Roar" Episode 8 |
| Martin Mull | Mr. Harris | "If I'm Dyin', I'm Lyin'" Episode 9 |
| James Carville | Himself | "Running Mates" Episode 10 |
| Lee Majors | Himself | "Running Mates" Episode 10 |
| Dwight Schultz | Randall Fargus | "Running Mates" Episode 10 |
| Jack Sheldon | 'Vagina Junction' conductor | "Running Mates" Episode 10 |
| Candice Bergen | Murphy Brown | "A Picture is Worth 1,000 Bucks" Episode 11 |
| Charles Kimbrough | Jim Dial | "A Picture is Worth 1,000 Bucks" Episode 11 |
| Joe Regalbuto | Frank Fontana Bull Editor | "A Picture is Worth 1,000 Bucks" Episode 11 |
| Brian Doyle-Murray | Luke | "Road to Rhode Island" Episode 13 |
| Victoria Principal | Dr. Amanda Rebecca | "Road to Rhode Island" Episode 13 |
| Gregg Allman | Himself | "Let's Go to the Hop" Episode 14 |
| Mo Collins | Daycare teacher Stewardess | "Dammit Janet!" Episode 15 |
| Haley Joel Osment | Leonard Daycare kid | "Dammit Janet!" Episode 15 |
| Camryn Manheim | Brad | "Dammit Janet!" Episode 15 |
| Michael Chiklis | Big Fat Paulie | "There's Something About Paulie" Episode 16 |
| Robert Costanzo | Biff Louie | "There's Something About Paulie" Episode 16 |
| Jon Cryer | Kevin | "There's Something About Paulie" Episode 16 |
| Alan King | The Don | "There's Something About Paulie" Episode 16 |
| Jay Mohr | Logan | "He's Too Sexy for His Fat" Episode 17 |
| Shawn Pyfrom | Oliver | "E. Peterbus Unum" Episode 18 |
| Luke Perry | Himself | "The Story on Page One" Episode 19 |
| Adam Carolla | Death | "Wasted Talent" Episode 20 |
| Michael McKean | Pawtucket Pat | "Wasted Talent" Episode 20 |
| Julia Sweeney | Woman in bar | "Wasted Talent" Episode 20 |
$^*$Live-action role $^†$Uncredited $^{JP}$This would be Jack Perkins' final film/television series role. $^{GA}$This would be Gregg Allman's final film/television series role.

## Season 3

| Name | Role(s) | Episode |
| June Foray | Rocket J. Squirrel | "The Thin White Line" Episode 1 |
| Leif Garrett | Himself | "The Thin White Line" Episode 1 |
| Haley Joel Osment | Kid in bathroom | "The Thin White Line" Episode 1 |
| Louise DuArt | Joan Rivers | "Brian Does Hollywood" Episode 2 |
| Olivia Hack | Melissa Rivers | "Brian Does Hollywood" Episode 2 |
| Jenna Jameson | Herself | "Brian Does Hollywood" Episode 2 |
| Ron Jeremy | Himself | "Brian Does Hollywood" Episode 2 |
| Ray Liotta | Zack | "Brian Does Hollywood" Episode 2 |
| Ricky Blitt | Alyssa Milano's lawyer | "Mr. Griffin Goes to Washington" Episode 3 |
| Alyssa Milano | Herself | "Mr. Griffin Goes to Washington" Episode 3 |
| Jack Sheldon | The Bill | "Mr. Griffin Goes to Washington" Episode 3 |
| Ed Asner | Brown-Haired Prisoner | "One If By Clam, Two If By Sea" Episode 4 |
| Hugh Laurie | Bar patron | "One If By Clam, Two If By Sea" Episode 4 |
| Patrick Duffy | Jack Salesman Teacher | "And the Wiener Is..." Episode 5 |
| Adam Carolla | Death | "Death Lives" Episode 6 |
| Estelle Harris | Death's mother | "Death Lives" Episode 6 |
| Peter Frampton | Himself | "Death Lives" Episode 6 |
| Laura Silverman | Amy | "Death Lives" Episode 6 |
| Michael Chiklis | Bronx guy #1 | "Lethal Weapons" Episode 7 |
| Peter Gallagher | Jared | "Lethal Weapons" Episode 7 |
| Hugh Downs | Himself | "The Kiss Seen Around the World" Episode 8 |
| Josh Peck | Charlie | "The Kiss Seen Around the World" Episode 8 |
| Abe Vigoda | Himself | "The Kiss Seen Around the World" Episode 8 |
| Adam Carolla | Death | "Mr. Saturday Knight" Episode 9 |
| R. Lee Ermey | Coach | "Mr. Saturday Knight" Episode 9 |
| Will Ferrell | The Black Knight | "Mr. Saturday Knight" Episode 9 |
| Jimmy Kimmel | Death's dog Man in suit Renaissance guy | "Mr. Saturday Knight" Episode 9 |
| Michael Chiklis | Hennessey | "A Fish Out of Water" Episode 10 |
| Brian Doyle-Murray | Salty | "A Fish Out of Water" Episode 10 |
| Alfonso Ribeiro | Himself | "A Fish Out of Water" Episode 10 |
| Majel Barrett | Ship computer | "Emission Impossible" Episode 11 |
| Carol Kane | Carol | "Emission Impossible" Episode 11 |
| Wallace Shawn | Bertram | "Emission Impossible" Episode 11 |
| Dakota Fanning | Little girl | "To Love and Die in Dixie" Episode 12 |
| Waylon Jennings | Himself | "To Love and Die in Dixie" Episode 12 |
| Kathleen Wilhoite | Sam | "To Love and Die in Dixie" Episode 12 |
| Bob Barker | Himself | "Screwed the Pooch" Episode 13 |
| Don LaFontaine | FOX Announcer | "Screwed the Pooch" Episode 13 |
| Meredith Scott Lynn | Brenda | "Peter Griffin: Husband, Father...Brother?" Episode 14 |
| Valerie Bertinelli | Herself as Bonnie Swanson | "Ready, Willing, and Disabled" Episode 15 |
| Tony Danza | Himself as Joe Swanson | "Ready, Willing, and Disabled" Episode 15 |
| Alex Rocco | Bea Arthur as Peter Griffin | "Ready, Willing, and Disabled" Episode 15 |
| KISS Peter Criss Ace Frehley Gene Simmons Paul Stanley | Themselves | "A Very Special Family Guy Freakin' Christmas" Episode 16 |
| Fred Willard | Dave Campbell | "From Method to Madness" Episode 18 |
| Jennifer Love Hewitt | Herself | "Stuck Together, Torn Apart" Episode 19 |
| Andy Dick | Himself | "Road to Europe" Episode 20 |
| Jon Favreau | Donny Sciberra First bazaar salesman | "Road to Europe" Episode 20 |
| Lauren Graham | Mother Maggie | "Road to Europe" Episode 20 |
| KISS | Themselves | "Road to Europe" Episode 20 |
| Jane Lynch | Dotty Campbell | "Road to Europe" Episode 20 |
| Michael McKean | Pengrove Pig Andy Rooney Camel salesman | "Road to Europe" Episode 20 |
| Fred Willard | Dave Campbell | "Road to Europe" Episode 20 |
| Adam Carolla | Death | "Family Guy Viewer Mail 1" Episode 21 |
| Bill Goldberg | Brawny guy on bus | "Family Guy Viewer Mail 1" Episode 21 |
| Regis Philbin | Himself | "Family Guy Viewer Mail 1" Episode 21 |
| Kelly Ripa | Herself | "Family Guy Viewer Mail 1" Episode 21 |
| Alex Trebek | Himself | "Family Guy Viewer Mail 1" Episode 21 |
| Michael Winslow | Himself | "Family Guy Viewer Mail 1" Episode 21 |
| Ricky Blitt | Mordecai | "When You Wish Upon a Weinstein" Episode 22 |
| Ed McMahon | Himself | "When You Wish Upon a Weinstein" Episode 22 |
| Mark Hamill | Luke Skywalker Obi-Wan Kenobi | "When You Wish Upon a Weinstein" Episode 22 |
| Peter Riegert | Max Weinstein | "When You Wish Upon a Weinstein" Episode 22 |
| Ben Stein | Rabbi Goldberg | "When You Wish Upon a Weinstein" Episode 22 |
$^*$Live-action role $^†$Uncredited $^W$This would be Waylon Jennings' final television series role.

## Season 4

| Name | Role(s) | Episode |
| Hunter Gomez | Pinocchio | "North by North Quahog" Episode 1 |
| Don LaFontaine | Himself | "North by North Quahog" Episode 1 |
| André Sogliuzzo | Mel Gibson Chris Tucker Hotel manager | "North by North Quahog" Episode 1 |
| Drew Barrymore | Mrs. Lockhart | "Fast Times at Buddy Cianci, Jr. High" Episode 2 |
| Arif S. Kinchen | Carlos | "Fast Times at Buddy Cianci, Jr. High" Episode 2 |
| Hugh Laurie | TV presenter | "Fast Times at Buddy Cianci, Jr. High" Episode 2 |
| Steven Zirnkilton | Himself | "Fast Times at Buddy Cianci, Jr. High" Episode 2 |
| Gina Gershon | Policewoman | "Blind Ambition" Episode 3 |
| Judd Hirsch | Himself | "Blind Ambition" Episode 3 |
| Jimmy Iovine | Himself | "Don't Make Me Over" Episode 4 |
| Gene Simmons | Himself Prisoner #3 | "Don't Make Me Over" Episode 4 |
| Emeril Lagasse | Himself | "The Cleveland-Loretta Quagmire" Episode 5 |
| LeVar Burton | Vern | "Petarded" Episode 6 |
| Cloris Leachman | Herself | "Petarded" Episode 6 |
| Natasha Melnick | Ruth Cochamer | "Petarded" Episode 6 |
| Michael York | British man | "Petarded" Episode 6 |
| Jessica Biel | Brooke | "Brian the Bachelor" Episode 7 |
| Nancy Cartwright | Daffney | "Brian the Bachelor" Episode 7 |
| Drew Pinsky | The Dermatologist | "Brian the Bachelor" Episode 7 |
| Joanna García | Liddane | "8 Simple Rules for Buying My Teenage Daughter" Episode 8 |
| Brian Tochi | Helicopter pilot | "Breaking Out Is Hard to Do" Episode 9 |
| Michael Dorn | Worf | "Peter's Got Woods" Episode 11 |
| Jonathan Frakes | William Riker | "Peter's Got Woods" Episode 11 |
| Patrick Stewart | Jean-Luc Picard | "Peter's Got Woods" Episode 11 |
| Gabrielle Union | Shauna Parks | "Peter's Got Woods" Episode 11 |
| James Woods | Himself | "Peter's Got Woods" Episode 11 |
| Adam Carolla | Death | "Perfect Castaway" Episode 12 |
| Jenna von Oÿ | Rory | "Perfect Castaway" Episode 12 |
| Carrie Fisher | Angela | "Jungle Love" Episode 13 |
| Mía Maestro | Loca | "Jungle Love" Episode 13 |
| Jay Mohr | Joe Pesci | "Jungle Love" Episode 13 |
| Bob Barker | Himself | "The Fat Guy Strangler" Episode 17 |
| Robert Downey Jr. | Patrick Pewterschmidt | "The Fat Guy Strangler" Episode 17 |
| Will Sasso | Todd | "The Fat Guy Strangler" Episode 17 |
| Paula Abdul | Herself | "The Father, the Son, and the Holy Fonz" Episode 18 |
| Tom Bosley | Howard Cunningham | "The Father, the Son, and the Holy Fonz" Episode 18 |
| Sherman Hemsley | Himself | "The Father, the Son, and the Holy Fonz" Episode 18 |
| Marion Ross | Marion Cunningham | "The Father, the Son, and the Holy Fonz" Episode 18 |
| Sarah Utterback | Lindsay Lohan | "The Father, the Son, and the Holy Fonz" Episode 18 |
| Mark Borchardt | Himself | "Brian Sings and Swings" Episode 19 |
| Frank Sinatra Jr. | Himself | "Brian Sings and Swings" Episode 19 |
| Jeff Bergman | Fred Flintstone | "Patriot Games" Episode 20 |
| Tom Brady | Himself | "Patriot Games" Episode 20 |
| Troy Brown | Himself | "Patriot Games" Episode 20 |
| Carol Channing | Herself | "Patriot Games" Episode 20 |
| Bob Costas | Himself | "Patriot Games" Episode 20 |
| Jay Leno | Himself | "Patriot Games" Episode 20 |
| Alexander Siddig | One of the London Silly Nannies | "Patriot Games" Episode 20 |
| Adam Carolla | Death | "I Take Thee Quagmire" Episode 21 |
| Bryan Cranston | Himself | "I Take Thee Quagmire" Episode 21 |
| Beth Littleford | Jane Kaczmarek Mother at park | "I Take Thee Quagmire" Episode 21 |
| Christy Carlson Romano | Quagmire's one-night stand | "I Take Thee Quagmire" Episode 21 |
| Alex Trebek | Himself | "I Take Thee Quagmire" Episode 21 |
| Wallace Shawn | Bertram | "Sibling Rivalry" Episode 22 |
| Chris Wedge | Scrat | "Sibling Rivalry" Episode 22 |
| Kate Jackson | Mrs. King | "Deep Throats" Episode 23 |
| Frank Welker | Fred Jones Kermit the Frog | "Deep Throats" Episode 23 |
| Tamera Mowry | Book customer | "Peterotica" Episode 24 |
| Betty White | Herself | "Peterotica" Episode 24 |
| Stark Sands | Justin Hackeysack | "You May Now Kiss the...Uh...Guy Who Receives" Episode 25 |
| Bob Costas | Himself | "Petergeist" Episode 26 |
| Carrot Top | Himself | "Petergeist" Episode 26 |
| Judith Light | Herself | "Untitled Griffin Family History" Episode 27 |
| Drew Barrymore | Herself | "Stewie B. Goode" Episode 28 |
| Noel Blanc | Elmer Fudd | "Stewie B. Goode" Episode 28 |
| Ron Livingston | Video store clerk | "Stewie B. Goode" Episode 28 |
| René Auberjonois | Odo | "Bango Was His Name, Oh!" Episode 29 |
| Jennie Garth | Kelly Taylor | "Bango Was His Name, Oh!" Episode 29 |
| Larry Kenney | Lion-O | "Bango Was His Name, Oh!" Episode 29 |
| Lynne Lipton | Cheetara | "Bango Was His Name, Oh!" Episode 29 |
| Jason Priestley | Brandon Walsh | "Bango Was His Name, Oh!" Episode 29 |
| Tori Spelling | Donna Martin | "Bango Was His Name, Oh!" Episode 29 |
| Joy Behar | Herself | "Stu and Stewie's Excellent Adventure" Episode 30 |
| Michael Clarke Duncan | Stork | "Stu and Stewie's Excellent Adventure" Episode 30 |
| Kiefer Sutherland | 24 opening narrator | "Stu and Stewie's Excellent Adventure" Episode 30 |
$^*$Live-action role $^#$Archive footage $^†$Uncredited $^C$This would be Carol Channing's final film/television role.

## Season 5

| Name | Role(s) | Episode |
| Ellen Albertini Dow | Elderly woman | "Stewie Loves Lois" Episode 1 |
| Phyllis Diller | Thelma Griffin | "Mother Tucker" Episode 2 |
| Tamera Mowry | Esther | "Mother Tucker" Episode 2 |
| Gore Vidal | Himself | "Mother Tucker" Episode 2 |
| Louis Gossett Jr. | Himself | "Saving Private Brian" Episode 4 |
| Samm Levine | Joey | "Saving Private Brian" Episode 4 |
| Drew Barrymore | Jillian | "Whistle While Your Wife Works" Episode 5 |
| Carrie Fisher | Angela | "Whistle While Your Wife Works" Episode 5 |
| Drew Barrymore | Jillian | "Prick Up Your Ears" Episode 6 |
| David Cross | Jerry Kirkwood | "Prick Up Your Ears" Episode 6 |
| Drew Barrymore | Jillian | "Chick Cancer" Episode 7 |
| Drew Barrymore | Jillian | "Barely Legal" Episode 8 |
| Garrett Morris | Headmaster of the New York School for the Hard of Hearing | "Barely Legal" Episode 8 |
| Tamera Mowry | Esther | "Barely Legal" Episode 8 |
| Bill Fagerbakke | Patrick Star | "Road to Rupert" Episode 9 |
| Gene Kelly | Joseph Brady | "Road to Rupert" Episode 9 |
| Tom Kenny | SpongeBob SquarePants | "Road to Rupert" Episode 9 |
| Rob Lowe | Stanford Cordray | "Road to Rupert" Episode 9 |
| George Wendt | Norm Peterson | "Road to Rupert" Episode 9 |
| Phyllis Diller | Thelma Griffin | "Peter's Two Dads" Episode 10 |
| Charles Durning | Francis Griffin | "Peter's Two Dads" Episode 10 |
| Tamera Mowry | Waitress | "Peter's Two Dads" Episode 10 |
| Keir Gilchrist | Kyle | "The Tan Aquatic with Steve Zissou" Episode 11 |
| Hugh Hefner | Himself | "Airport '07" Episode 12 |
| Roy Scheider | Himself | "Bill and Peter's Bogus Journey" Episode 13 |
| Conway Twitty | Himself | "Bill and Peter's Bogus Journey" Episode 13 |
| Patrick Stewart | Peter Griffin with Patrick Stewart's voice | "No Meals on Wheels" Episode 14 |
| Ben Stiller | Himself | "No Meals on Wheels" Episode 14 |
| Drew Barrymore | Jillian | "Boys Do Cry" Episode 15 |
| Bill Engvall | Duke Dillon | "Boys Do Cry" Episode 15 |
| Gilbert Gottfried | Horse | "Boys Do Cry" Episode 15 |
| Neil Patrick Harris | Barney Stinson | "No Chris Left Behind" Episode 16 |
| Josh Radnor | Ted Mosby | "No Chris Left Behind" Episode 16 |
| Ashley Ferl | Herself | "It Takes a Village Idiot, and I Married One" Episode 17 |
| Don Most | Himself | "It Takes a Village Idiot, and I Married One" Episode 17 |
| Keith Olbermann | Bob Grossbeard | "It Takes a Village Idiot, and I Married One" Episode 17 |
| Adam Carolla | Death | "Meet the Quagmires" Episode 18 |
| Seth MacFarlane | Roger the Alien | "Meet the Quagmires" Episode 18 |
$^*$Live-action role $^#$Archive footage $^†$Uncredited $^G$This would be Gore Vidal's final television role.

## Season 6

| Name | Role(s) | Episode |
| Chevy Chase | Clark Griswold | "Blue Harvest" Episode 1 |
| Beverly D'Angelo | Ellen Griswold | "Blue Harvest" Episode 1 |
| Mick Hucknall | Himself | "Blue Harvest" Episode 1 |
| Rush Limbaugh | Himself | "Blue Harvest" Episode 1 |
| Judd Nelson | John Bender | "Blue Harvest" Episode 1 |
| Leslie Nielsen | Dr. Rumack | "Blue Harvest" Episode 1 |
| Helen Reddy | Herself | "Blue Harvest" Episode 1 |
| Drew Barrymore | Jillian | "Movin' Out (Brian's Song)" Episode 2 |
| Jeff Bergman | Homer Simpson | "Movin' Out (Brian's Song)" Episode 2 |
| Jamie Farr | Himself | "Believe It or Not, Joe's Walking on Air" Episode 3 |
| Paula Abdul | American Idol judges | "Lois Kills Stewie" Episode 5 |
| Simon Cowell | American Idol judges | "Lois Kills Stewie" Episode 5 |
| Randy Jackson | American Idol judges | "Lois Kills Stewie" Episode 5 |
| Seth MacFarlane | Stan Smith | "Lois Kills Stewie" Episode 5 |
| Patrick Stewart | Avery Bullock | "Lois Kills Stewie" Episode 5 |
| Phyllis Diller | Thelma Griffin | "Padre de Familia" Episode 6 |
| Alex Fernandez | Gerardo | "Padre de Familia" Episode 6 |
| Carrie Fisher | Angela | "Padre de Familia" Episode 6 |
| Gabriel Iglesias | Mexican #5 | "Padre de Familia" Episode 6 |
| Jeff Bergman | Fred Flintstone | "Peter's Daughter" Episode 7 |
| Pat Crawford Brown | Sanka dancer | "Peter's Daughter" Episode 7 |
| Conway Twitty | Himself | "Peter's Daughter" Episode 7 |
| Ricardo Montalbán | The Cow | "McStroke" Episode 8 |
| Barry Manilow | Himself | "Back to the Woods" Episode 9 |
| David Van Dam | David Letterman | "Back to the Woods" Episode 9 |
| James Woods | Himself | "Back to the Woods" Episode 9 |
| Chace Crawford | Dylan | "The Former Life of Brian" Episode 11 |
| Harvey Fierstein | Tracy | "The Former Life of Brian" Episode 11 |
| Amanda Bynes | Anna | "Long John Peter" Episode 12 |
$^D$Appearance in a deleted scene only $^#$Archive footage $^*$Live-action role

## Season 7

| Name | Role(s) | Episode |
| Meredith Baxter | Herself | "Love Blactually" Episode 1 |
| Kat Foster | Carolyn | "Love Blactually" Episode 1 |
| Ike Barinholtz | Dane Cook | "I Dream of Jesus" Episode 2 |
| Russ Leatherman | Mr. Moviefone | "I Dream of Jesus" Episode 2 |
| Debra Wilson | Star Jones | "I Dream of Jesus" Episode 2 |
| Brian Blessed | Prince Vultan | "Road to Germany" Episode 3 |
| Gregory Jbara | Nazi guard Nazi general German priest | "Road to Germany" Episode 3 |
| Johnny Knoxville | Himself | "The Man with Two Brians" Episode 5 |
| Bob Barker | Himself | "Tales of a Third Grade Nothing" Episode 6 |
| Elisha Cuthbert | New Bedford | "Tales of a Third Grade Nothing" Episode 6 |
| Andy Dick | Himself | "Tales of a Third Grade Nothing" Episode 6 |
| Caitlyn Jenner | Bruce Jenner | "Tales of a Third Grade Nothing" Episode 6 |
| Debbie Reynolds | Mrs. Wilson | "Tales of a Third Grade Nothing" Episode 6 |
| Frank Sinatra Jr. | Himself | "Tales of a Third Grade Nothing" Episode 6 |
| Sinbad | Himself | "Tales of a Third Grade Nothing" Episode 6 |
| J.P. Manoux | Alan Harper | "Ocean's Three and a Half" Episode 7 |
| Frank Welker | Megatron | "Ocean's Three and a Half" Episode 7 |
| Meredith Baxter | Herself | "Family Gay" Episode 8 |
| Seth Rogen | Peter Griffin with the Seth Rogen gene | "Family Gay" Episode 8 |
| Jeff Bergman | O. J. Simpson | "The Juice Is Loose" Episode 9 |
| Conway Twitty | Himself | "The Juice Is Loose" Episode 9 |
| Peter Chernin | Himself | "FOX-y Lady" Episode 10 |
| Ed Helms | Al Gore | "FOX-y Lady" Episode 10 |
| John Moschitta Jr. | Himself | "FOX-y Lady" Episode 10 |
| Seth Rogen | Himself | "FOX-y Lady" Episode 10 |
| Fred Savage | Himself | "FOX-y Lady" Episode 10 |
| Daniel Stern | Fred Savage's voice over | "FOX-y Lady" Episode 10 |
| LeVar Burton | Star Trek: The Next Generation cast | "Not All Dogs Go to Heaven" Episode 11 |
| Denise Crosby | Star Trek: The Next Generation cast | "Not All Dogs Go to Heaven" Episode 11 |
| Michael Dorn | Star Trek: The Next Generation cast | "Not All Dogs Go to Heaven" Episode 11 |
| Jonathan Frakes | Star Trek: The Next Generation cast | "Not All Dogs Go to Heaven" Episode 11 |
| Gates McFadden | Star Trek: The Next Generation cast | "Not All Dogs Go to Heaven" Episode 11 |
| Marina Sirtis | Star Trek: The Next Generation cast | "Not All Dogs Go to Heaven" Episode 11 |
| Brent Spiner | Star Trek: The Next Generation cast | "Not All Dogs Go to Heaven" Episode 11 |
| Patrick Stewart | Star Trek: The Next Generation cast | "Not All Dogs Go to Heaven" Episode 11 |
| Wil Wheaton | Star Trek: The Next Generation cast | "Not All Dogs Go to Heaven" Episode 11 |
| Rob Lowe | Themselves | "Not All Dogs Go to Heaven" Episode 11 |
| Adam West | Themselves | "Not All Dogs Go to Heaven" Episode 11 |
| Meredith Baxter | Elyse Keaton | "Stew-Roids" Episode 13 |
| Chace Crawford | Jock #2 Popular kid Trainer | "Stew-Roids" Episode 13 |
| Camille Guaty | Gina | "Stew-Roids" Episode 13 |
| Wentworth Miller | Jock #4 Popular kid #2 | "Stew-Roids" Episode 13 |
| Drew Barrymore | Jillian | "We Love You, Conrad" Episode 14 |
| Lauren Conrad | Herself | "We Love You, Conrad" Episode 14 |
| Jimmy Fallon | Himself | "We Love You, Conrad" Episode 14 |
| Craig Ferguson | Himself | "We Love You, Conrad" Episode 14 |
| Jay Leno | Himself | "We Love You, Conrad" Episode 14 |
| Audrina Patridge | Herself | "We Love You, Conrad" Episode 14 |
| Kate Todd | Heidi Montag | "We Love You, Conrad" Episode 14 |
| Sarah Utterback | Lindsay Lohan | "We Love You, Conrad" Episode 14 |
| Richard Dreyfuss | Narrator | "Three Kings" Episode 15 |
| Roy Scheider | Himself | "Three Kings" Episode 15 |
| George Wendt | Norm Peterson | "Three Kings" Episode 15 |
| Neil Patrick Harris | How I Met Your Mother cast | "Peter's Progress" Episode 16 |
| Josh Radnor | How I Met Your Mother cast | "Peter's Progress" Episode 16 |
| Jason Segel | How I Met Your Mother cast | "Peter's Progress" Episode 16 |
$^*$Live-action role $^#$Archive footage $^B$Taking place prior to her coming out as trans and undergoing gender reassignment surgery, Caitlyn was considered to be playing herself, as she was known then as Bruce Jenner. $^R$This would be Roy Scheider's final film/television role.

## Season 8

| Name | Role(s) | Episode |
| Jeff Bergman | Max Weinstein | "Family Goy" Episode 2 |
| Charles Durning | Francis Griffin | "Family Goy" Episode 2 |
| Ben Stein | Rabbi Goldberg | "Family Goy" Episode 2 |
| William Woodson | Super Friends announcer | "Family Goy" Episode 2 |
| Dan Aykroyd | Themselves | "Spies Reminiscent of Us" Episode 3 |
| Chevy Chase | Themselves | "Spies Reminiscent of Us" Episode 3 |
| Gary Cole | Mike Brady | "Spies Reminiscent of Us" Episode 3 |
| James Lipton | Himself | "Spies Reminiscent of Us" Episode 3 |
| Hart Bochner | Harry Ellis | "Brian's Got a Brand New Bag" Episode 4 |
| George Christy | Dr. Hasseldorf | "Brian's Got a Brand New Bag" Episode 4 |
| Paul Gleason | Deputy Chief Dwayne T. Robinson | "Brian's Got a Brand New Bag" Episode 4 |
| Reginald VelJohnson | Sgt. Al Powell | "Brian's Got a Brand New Bag" Episode 4 |
| Nana Visitor | Rita | "Brian's Got a Brand New Bag" Episode 4 |
| Tico Wells | Bobby Brown | "Brian's Got a Brand New Bag" Episode 4 |
| Bruce Willis | John McClane | "Brian's Got a Brand New Bag" Episode 4 |
| Candace Marie | Miley Cyrus | "Hannah Banana" Episode 5 |
| Brittany Snow | Candy | "Quagmire's Baby" Episode 6 |
| Thomas F. Wilson | First step | "Quagmire's Baby" Episode 6 |
| Nathan Gunn | Italian opera singer | "Dog Gone" Episode 8 |
| Chris Matthews | Himself | "Dog Gone" Episode 8 |
| Johnny Galecki | Leonard Hofstadter | "Business Guy" Episode 9 |
| Hugh Laurie | Gregory House | "Business Guy" Episode 9 |
| Bobby Lee | Sharply dressed Asian man | "Business Guy" Episode 9 |
| Jim Parsons | Sheldon Cooper | "Business Guy" Episode 9 |
| Dwayne Johnson | Himself | "Big Man on Hippocampus" Episode 10 |
| Adrianne Palicki | Tiffani Amber Thiessen | "Big Man on Hippocampus" Episode 10 |
| Dave Boat | Latino in hardhat | "Dial Meg for Murder" Episode 11 |
| Peter Chen | Chinese NASCAR drivers | "Dial Meg for Murder" Episode 11 |
| Chace Crawford | Luke | "Dial Meg for Murder" Episode 11 |
| Camille Guaty | Gina | "Dial Meg for Murder" Episode 11 |
| Allison Janney | Teen People editor | "Dial Meg for Murder" Episode 11 |
| Andrea Fay Friedman | Ellen | "Extra Large Medium" Episode 12 |
| Michele Lee | Estelle Harris | "Extra Large Medium" Episode 12 |
| Stephen Bishop | Himself | "Go Stewie Go" Episode 13 |
| Mo Collins | Little girl | "Go Stewie Go" Episode 13 |
| Colin Ford | Randall | "Go Stewie Go" Episode 13 |
| Anne Hathaway | Mother Maggie | "Go Stewie Go" Episode 13 |
| Nana Visitor | Audition caller | "Go Stewie Go" Episode 13 |
| Max Burkholder | Child doctor | "Peter-assment" Episode 14 |
| Richard Dreyfuss | Himself | "Peter-assment" Episode 14 |
| Carrie Fisher | Angela | "Peter-assment" Episode 14 |
| Jim Goldenberg | TMZ crew | "Peter-assment" Episode 14 |
| Max Hodges | TMZ crew | "Peter-assment" Episode 14 |
| Harvey Levin | TMZ crew | "Peter-assment" Episode 14 |
| Rob Lotterstein | Himself | "Brian Griffin's House of Payne" Episode 15 |
| Danielle Panabaker | James Woods' daughter | "Brian Griffin's House of Payne" Episode 15 |
| Charlie Sheen | Himself | "Brian Griffin's House of Payne" Episode 15 |
| Elijah Wood | Himself | "Brian Griffin's House of Payne" Episode 15 |
| James Woods | Himself | "Brian Griffin's House of Payne" Episode 15 |
| Anne Hathaway | Herself | "April in Quahog" Episode 16 |
| Jason Mraz | Some guy with a hat | "April in Quahog" Episode 16 |
| Marc Alaimo | The Dean | "The Splendid Source" Episode 19 |
| Sanaa Lathan | Donna Tubbs-Brown | "The Splendid Source" Episode 19 |
| David Lynch | Gus the Bartender | "The Splendid Source" Episode 19 |
| Kevin Michael Richardson | Cleveland Brown, Jr. | "The Splendid Source" Episode 19 |
| John Bunnell | Himself | "Something Something Something Dark Side" Episode 20 |
| James Caan | Himself | "Something Something Something Dark Side" Episode 20 |
| Joe Flaherty | Western Union man | "Something Something Something Dark Side" Episode 20 |
| Dolph Lundgren | Ivan Drago | "Something Something Something Dark Side" Episode 20 |
| Brigitte Nielsen | Ludmilla Vobet Drago | "Something Something Something Dark Side" Episode 20 |
| Michael Pataki | Nicoli Koloff | "Something Something Something Dark Side" Episode 20 |
| Tom Selleck | Phil Blackwood | "Something Something Something Dark Side" Episode 20 |
| James Woods | Himself/General Veers | "Something Something Something Dark Side" Episode 20 |
| Julia Sweeney | Naomi Robinson | "Partial Terms of Endearment" Episode 21 |
| Wil Wheaton | Protestor | "Partial Terms of Endearment" Episode 21 |
| Michael York | Nature narrator | "Partial Terms of Endearment" Episode 21 |
$^*$Live-action role $^#$Archive footage $^{WW}$This marked William Woodson's final film/television role.

## Season 9

| Name | Role(s) | Episode |
| Drew Barrymore | Jillian | "And Then There Were Fewer" Episode 1 |
| Max Burkholder | Child | "And Then There Were Fewer" Episode 1 |
| Colin Ford | Child | "And Then There Were Fewer" Episode 1 |
| Patrick Stewart | Cat | "And Then There Were Fewer" Episode 1 |
| Ashley Tisdale | Priscilla | "And Then There Were Fewer" Episode 1 |
| James Woods | Himself | "And Then There Were Fewer" Episode 1 |
| Rush Limbaugh | Himself | "Excellence in Broadcasting" Episode 2 |
| Shelley Long | Carol Brady | "Excellence in Broadcasting" Episode 2 |
| Nana Visitor | Nancy Pelosi | "Excellence in Broadcasting" Episode 2 |
| Rainn Wilson | Dwight Schrute | "Excellence in Broadcasting" Episode 2 |
| Max Burkholder | Altar boy mouse | "Welcome Back, Carter" Episode 3 |
| Barclay DeVeau | Patty | "Halloween on Spooner Street" Episode 4 |
| Noah Matthews | Bully | "Halloween on Spooner Street" Episode 4 |
| Natasha Melnick | Ruth | "Halloween on Spooner Street" Episode 4 |
| Christina Milian | Esther | "Halloween on Spooner Street" Episode 4 |
| Lyndon Smith | Bully #2 | "Halloween on Spooner Street" Episode 4 |
| Patrick Stewart | Dick Pump | "Halloween on Spooner Street" Episode 4 |
| Nana Visitor | Justin's mom | "Halloween on Spooner Street" Episode 4 |
| Lisa Wilhoit | Connie D'Amico | "Halloween on Spooner Street" Episode 4 |
| Carrie Fisher | Angela | "Baby, You Knock Me Out" Episode 5 |
| Dana Gould | Himself | "Brian Writes a Bestseller" Episode 6 |
| Arianna Huffington | Herself | "Brian Writes a Bestseller" Episode 6 |
| Bill Maher | Himself | "Brian Writes a Bestseller" Episode 6 |
| Ashley Tisdale | Kelly | "Brian Writes a Bestseller" Episode 6 |
| Drew Barrymore | Jillian | "Road to the North Pole" Episode 7 |
| David Boreanaz | Himself | "Road to the North Pole" Episode 7 |
| Carrie Fisher | Angela | "Road to the North Pole" Episode 7 |
| Ron MacFarlane | The Narrator | "Road to the North Pole" Episode 7 |
| Bruce McGill | Santa Claus | "Road to the North Pole" Episode 7 |
| Will Ryan | Winnie-the-Pooh | "Road to the North Pole" Episode 7 |
| Nana Visitor | Mother | "Road to the North Pole" Episode 7 |
| Yvette Nicole Brown | Black woman | "New Kidney in Town" Episode 8 |
| Drew Carey | Himself | "New Kidney in Town" Episode 8 |
| Kirker Butler | Guest | "And I'm Joyce Kinney" Episode 9 |
| Helen Reddy | Herself | "And I'm Joyce Kinney" Episode 9 |
| Adam Carolla | Death | "Friends of Peter G." Episode 10 |
| Carrie Fisher | Angela | "Friends of Peter G." Episode 10 |
| Jessica Stroup | Crowd member | "Friends of Peter G." Episode 10 |
| Laura Vandervoort | AA member | "Friends of Peter G." Episode 10 |
| Alan Tudyk | German pilot | "German Guy" Episode 11 |
| Colin Ford | Kid | "The Hand That Rocks the Wheelchair" Episode 12 |
| Patrick Stewart | Susie Swanson | "The Hand That Rocks the Wheelchair" Episode 12 |
| Nina Dobrev | Gina | "Trading Places" Episode 13 |
| Carrie Fisher | Angela | "Trading Places" Episode 13 |
| Laura Vandervoort | Third Bully Girl | "Trading Places" Episode 13 |
| Lisa Wilhoit | Connie D'Amico | "Trading Places" Episode 13 |
| Drew Barrymore | Jillian | "Tiegs for Two" Episode 14 |
| Jessica Stroup | Denise | "Tiegs for Two" Episode 14 |
| Cheryl Tiegs | Herself | "Tiegs for Two" Episode 14 |
| Frank Welker | Megatron | "Tiegs for Two" Episode 14 |
| Meredith Baxter | Elise Keaton | "Brothers & Sisters" Episode 15 |
| Michael Gross | Steven Keaton | "Brothers & Sisters" Episode 15 |
| Julie Hagerty | Carol Pewterschmidt | "Brothers & Sisters" Episode 15 |
| Robert Loggia | Himself | "Brothers & Sisters" Episode 15 |
| Sarah Ramos | Teenage girl | "Brothers & Sisters" Episode 15 |
| Joe Flaherty | Vatican worker | "The Big Bang Theory" Episode 16 |
| Wallace Shawn | Bertram | "The Big Bang Theory" Episode 16 |
| David Bowie | Themselves | "Foreign Affairs" Episode 17 |
| Mick Jagger | Themselves | "Foreign Affairs" Episode 17 |
| Dee Bradley Baker | Klaus Heissler/Admiral Ackbar | "It's a Trap!" Episode 18 |
| Michael Dorn | Worf | "It's a Trap!" Episode 18 |
| Mary Hart | Herself | "It's a Trap!" Episode 18 |
| Anne Hathaway | Hot blonde | "It's a Trap!" Episode 18 |
| Rush Limbaugh | Rancor | "It's a Trap!" Episode 18 |
| Bruce McGill | John Williams | "It's a Trap!" Episode 18 |
| Patrick Stewart | Jean-Luc Picard | "It's a Trap!" Episode 18 |
| Conway Twitty | Darth Twitty | "It's a Trap!" Episode 18 |
$^*$Live-action role $^#$Archive footage

## Season 10

| Name | Role(s) | Episode |
| Judy Greer | Showgirl dancer | "Lottery Fever" Episode 1 |
| Dee Bradley Baker | Hooded monster | "Seahorse Seashell Party" Episode 2 |
| Kaitlin Olson | Brenda | "Screams of Silence: The Story of Brenda Q" Episode 3 |
| Adam Alexi-Malle | Adzin | "Stewie Goes for a Drive" Episode 4 |
| Ryan Reynolds | Himself | "Stewie Goes for a Drive" Episode 4 |
| Lacey Chabert | Pilot episode Meg | "Back to the Pilot" Episode 5 |
| Scott Grimes | Kevin Swanson | "Thanksgiving" Episode 6 |
| Julie Hagerty | Carol West | "Thanksgiving" Episode 6 |
| Patrick Stewart | Susie Swanson | "Thanksgiving" Episode 6 |
| Ari Graynor | Woman | "Amish Guy" Episode 7 |
| Bobby Lee | Chinese man | "Amish Guy" Episode 7 |
| Missi Pyle | Woman | "Amish Guy" Episode 7 |
| Kevin Michael Richardson | Roadblock | "Amish Guy" Episode 7 |
| Bob Gunton | Warden | "Cool Hand Peter" Episode 8 |
| Sanaa Lathan | Donna Tubbs-Brown | "Cool Hand Peter" Episode 8 |
| Adam Carolla | Death | "Grumpy Old Man" Episode 9 |
| Jack Carter | Old man | "Grumpy Old Man" Episode 9 |
| D.C. Douglas | Superman | "Grumpy Old Man" Episode 9 |
| R. Lee Ermey | Drill sergeant | "Grumpy Old Man" Episode 9 |
| Joel David Moore | Old man watching Avatar | "Grumpy Old Man" Episode 9 |
| Linda Porter | Old woman | "Grumpy Old Man" Episode 9 |
| Marlee Matlin | Stella | "The Blind Side" Episode 11 |
| Rob Corddry | Ben | "Livin' on a Prayer" Episode 12 |
| Judy Greer | Hope | "Livin' on a Prayer" Episode 12 |
| Mark Harmon | Leroy Jethro Gibbs | "Tom Tucker: The Man and His Dream" Episode 13 |
| Danielle Harris | Jamie Lloyd | "Tom Tucker: The Man and His Dream" Episode 13 |
| David Herman | David Strathairn | "Tom Tucker: The Man and His Dream" Episode 13 |
| Sanaa Lathan | Clair Huxtable | "Tom Tucker: The Man and His Dream" Episode 13 |
| Elliot Page | Lindsey | "Tom Tucker: The Man and His Dream" Episode 13 |
| George P. Wilbur | Michael Myers | "Tom Tucker: The Man and His Dream" Episode 13 |
| James Woods | Himself | "Tom Tucker: The Man and His Dream" Episode 13 |
| Ricky Gervais | Billy Finn | "Be Careful What You Fish For" Episode 14 |
| Lucy Davis | Joanne Finn | "Be Careful What You Fish For" Episode 14 |
| Scott Bakula | Himself | "Burning Down the Bayit" Episode 15 |
| Jeff Ross | Himself | "Killer Queen" Episode 16 |
| Eddie Kaye Thomas | Barry Robinson | "Killer Queen" Episode 16 |
| Katharine McPhee | Mother Maggie | "You Can't Do That on Television, Peter" Episode 18 |
| Cate Blanchett | Penelope | "Mr. and Mrs. Stewie" Episode 19 |
| Omid Abtahi | Prince Faisal | "Leggo My Meg-O" Episode 20 |
| Alexa Ray Joel | Young girl | "Tea Peter" Episode 21 |
| Anna Kendrick | Nora | "Internal Affairs" Episode 23 |
$^*$Live-action role $^#$Archive footage

## Season 11

| Name | Role(s) | Episode |
| Elizabeth Banks | Pam Fishman | "Into Fat Air" Episode 1 |
| J. J. Abrams | Himself | "Ratings Guy" Episode 2 |
| Sandra Bernhard | Herself | "Ratings Guy" Episode 2 |
| Mark Burnett | Himself | "Ratings Guy" Episode 2 |
| Dan Castellaneta | Homer Simpson | "Ratings Guy" Episode 2 |
| Michael Clarke Duncan | Co-worker with cowboy boots | "Ratings Guy" Episode 2 |
| Billy Gardell | Mike Biggs | "Ratings Guy" Episode 2 |
| Jon Hamm | Himself | "Ratings Guy" Episode 2 |
| Dick Wolf | Himself | "Ratings Guy" Episode 2 |
| John de Lancie | Pewterschmidt Industries executive | "The Old Man and the Big 'C'" Episode 3 |
| Jim Parsons | Gay-Jacker | "Joe's Revenge" Episode 5 |
| Will Sasso | Bobby 'The Shirt' Briggs | "Joe's Revenge" Episode 5 |
| Patrick Stewart | Susie Swanson | "Joe's Revenge" Episode 5 |
| Johnny Depp | Edward Scissorhands | "Lois Comes Out of Her Shell" Episode 6 |
| Ellen Albertini Dow | Aunt Helen | "Jesus, Mary and Joseph!" Episode 8 |
| Ryan Reynolds | Overweight guy | "Jesus, Mary and Joseph!" Episode 8 |
| Brian Williams | Himself | "Space Cadet" Episode 9 |
| Alan Bennett | Himself | "Brian's Play" Episode 10 |
| Megan Hilty | Helen Keller's teacher Old woman | "The Giggity Wife" Episode 11 |
| Sofía Vergara | Flower saleswoman Hispanic woman | "The Giggity Wife" Episode 11 |
| Drew Barrymore | Jillian Russell | "Valentine's Day in Quahog" Episode 12 |
| Jessica Biel | Brooke Roberts | "Valentine's Day in Quahog" Episode 12 |
| Kat Foster | Carolyn | "Valentine's Day in Quahog" Episode 12 |
| Jessica Stroup | Denise | "Valentine's Day in Quahog" Episode 12 |
| Cheryl Tiegs | Herself | "Valentine's Day in Quahog" Episode 12 |
| Nana Visitor | Rita | "Valentine's Day in Quahog" Episode 12 |
| Anne Murray | Herself | "Chris Cross" Episode 13 |
| Robert Romanus | Mike Damone | "Chris Cross" Episode 13 |
| Christine Baranski | Herself | "Call Girl" Episode 14 |
| Robert Loggia | Himself | "Call Girl" Episode 14 |
| Giovanni Ribisi | Randy | "Call Girl" Episode 14 |
| Omid Abtahi | Mahmoud | "Turban Cowboy" Episode 15 |
| Bob Costas | Himself | "Turban Cowboy" Episode 15 |
| Padma Lakshmi | Herself | "12 and a Half Angry Men" Episode 16 |
| Mike Judge | Hank Hill | "Bigfat" Episode 17 |
| Bill Maher | Himself | "Bigfat" Episode 17 |
| Wendy Schaal | Francine Smith | "Bigfat" Episode 17 |
| Carly Simon | Herself | "Total Recall" Episode 18 |
| Tim Gunn | Himself | "Save the Clam" Episode 19 |
| Hank Azaria | Reginald Barrington | "No Country Club for Old Men" Episode 22 |
| Sean Bean | Portrait of Peter Griffin's ancestor | "No Country Club for Old Men" Episode 22 |
| Nick Cannon | Himself | "No Country Club for Old Men" Episode 22 |
| Tom Hiddleston | Statue of Peter Griffin's ancestor | "No Country Club for Old Men" Episode 22 |
| Sharon Osbourne | Herself | "No Country Club for Old Men" Episode 22 |
| Emma Roberts | Amanda Barrington | "No Country Club for Old Men" Episode 22 |
$^*$Live-action role $^#$Archive footage $^{MCD}$Airing after his death, this episode was also dedicated in Michael's memory. $^R$This marked Robert Loggia's final appearance on a television series prior to his death in 2015.

## Season 12

| Name | Role(s) | Episode |
| Yvette Nicole Brown | Woman | "Finders Keepers" Episode 1 |
| Lea Thompson | Lorraine McFly | "Finders Keepers" Episode 1 |
| Carrie Fisher | Angela | "Vestigial Peter" Episode 2 |
| Patrick Stewart | Narrator | "Vestigial Peter" Episode 2 |
| Adam Levine | Himself | "Quagmire's Quagmire" Episode 3 |
| Jeff Daniels | Himself | "A Fistful of Meg" Episode 4 |
| Christina Milian | Esther | "A Fistful of Meg" Episode 4 |
| Michelle Dockery | British woman | "Boopa-dee Bappa-dee" Episode 5 |
| Yvette Nicole Brown | Mourning woman | "Life of Brian" Episode 6 |
| Tony Sirico | Vinny | "Life of Brian" Episode 6 |
| Nick Kroll | Ricky | "Into Harmony's Way" Episode 7 |
| Conan O'Brien | Himself | "Into Harmony's Way" Episode 7 |
| Tony Sirico | Vinny | "Into Harmony's Way" Episode 7 |
| Tony Sirico | Vinny | "Christmas Guy" Episode 8 |
| Carrie Fisher | Angela | "Peter Problems" Episode 9 |
| Marlee Matlin | Stella | "Peter Problems" Episode 9 |
| Brad Goreski | Gay man #1 | "Grimm Job" Episode 10 |
| Ashley Benson | Dakota | "Brian's a Bad Father" Episode 11 |
| Liam Neeson | Himself | "Brian's a Bad Father" Episode 11 |
| Lauren Bacall | Evelyn | "Mom's the Word" Episode 12 |
| Ariana Grande | Italian daughter | "Mom's the Word" Episode 12 |
| Adam Carolla | Death | "3 Acts of God" Episode 13 |
| C. J. Spiller | Himself | "3 Acts of God" Episode 13 |
| Mario Williams | Himself | "3 Acts of God" Episode 13 |
| Cary Elwes | Dr. Watson | "Secondhand Spoke" Episode 15 |
| Bryan Cranston | Himself | "Herpe the Love Sore" Episode 16 |
| Patrick Stewart | Cutaway narrator | "Herpe the Love Sore" Episode 16 |
| Dennis Farina | Himself | "The Most Interesting Man in the World" Episode 17 |
| Keke Palmer | Pam | "Baby Got Black" Episode 18 |
| Cedric Yarbrough | Lobster | "Baby Got Black" Episode 18 |
| Sanaa Lathan | Donna Tubbs-Brown | "He's Bla-ack!" Episode 20 |
| Cary Elwes | Dr. Watson | "Chap Stewie" Episode 21 |
| Isaac Hempstead-Wright | Aidan | "Chap Stewie" Episode 21 |
| Rick Springfield | Himself | "Chap Stewie" Episode 21 |
| David Thewlis | British father | "Chap Stewie" Episode 21 |
$^*$Live-action role $^L$This is Lauren Bacall's final film or television role prior to her death. $^D$This is Dennis Farina's final television role, airing after his death (in 2013).

## Season 13

| Name | Role(s) | Episode |
| Hank Azaria | Moe Szyslak Apu Nahasapeemapetilon Carl Carlson Chief Wiggum Comic Book Guy Lou Dr. Nick Riviera | "The Simpsons Guy" Episode 1 |
| H. Jon Benjamin | Bob Belcher | "The Simpsons Guy" Episode 1 |
| Jeff Bergman | Fred Flintstone | "The Simpsons Guy" Episode 1 |
| Julie Bowen | Claire Dunphy | "The Simpsons Guy" Episode 1 |
| Nancy Cartwright | Bart Simpson Maggie Simpson Nelson Muntz Ralph Wiggum Todd Flanders | "The Simpsons Guy" Episode 1 |
| Dan Castellaneta | Homer Simpson Abraham Simpson Krusty the Clown Barney Gumble Hans Moleman Kodos Mayor Quimby Santa's Little Helper Squeaky-Voiced Teen Blue-Haired Lawyer | "The Simpsons Guy" Episode 1 |
| Julie Kavner | Marge Simpson Patty and Selma | "The Simpsons Guy" Episode 1 |
| Harry Shearer | Lenny Leonard Video Erotich customer | "The Simpsons Guy" Episode 1 |
| Yeardley Smith | Lisa Simpson | "The Simpsons Guy" Episode 1 |
| James Woods | Himself | "The Simpsons Guy" Episode 1 |
| Mason Cook | Boy in wheelchair | "The Book of Joe" Episode 2 |
| Glenn Howerton | Blake Walker | "The Book of Joe" Episode 2 |
| Maya Rudolph | JoAnne Shalit | "The Book of Joe" Episode 2 |
| Connie Britton | Herself | "Baking Bad" Episode 3 |
| Carl Lumbly | Loan officer | "Baking Bad" Episode 3 |
| Ana Ortiz | Cinnamon | "Baking Bad" Episode 3 |
| Emily Osment | Girl in bed on TV | "Baking Bad" Episode 3 |
| Yvette Nicole Brown | Jerome's mom | "Brian the Closer" Episode 4 |
| Emily Osment | Uncomfortably Hot 18-Year-Old Girl | "Turkey Guys" Episode 5 |
| Jeff Garlin | Himself | "The 2000-Year-Old Virgin" Episode 6 |
| Ana Gasteyer | Speed dater | "The 2000-Year-Old Virgin" Episode 6 |
| Glenn Howerton | Massage chair guy | "The 2000-Year-Old Virgin" Episode 6 |
| Emily Osment | Girl in Santa Hat/Carrie Underwood | "The 2000-Year-Old Virgin" Episode 6 |
| Hank Azaria | Nigel Harpington | "Stewie, Chris & Brian's Excellent Adventure" Episode 7 |
| Tony Sirico | Himself | "Stewie, Chris & Brian's Excellent Adventure" Episode 7 |
| Emily Osment | Ruth | "Our Idiot Brian" Episode 8 |
| Allison Janney | Crystal Quagmire | "Quagmire's Mom" Episode 10 |
| Emily Osment | Kira | "Quagmire's Mom" Episode 10 |
| Nat Faxon | Jet Li villain | "Encyclopedia Griffin" Episode 11 |
| Allison Janney | Mistriss Vieda | "Encyclopedia Griffin" Episode 11 |
| Harvey Fierstein | Buster Keaton | "Stewie Is Enciente" Episode 12 |
| Lea Thompson | Teenaged girl in diner | "#JOLO" Episode 14 |
| Chris Hardwick | Johnny Lawrence | "Once Bitten" Episode 15 |
| Cristin Milioti | Karen Andrea | "Roasted Guy" Episode 16 |
| T.J. Miller | Volcano | "Roasted Guy" Episode 16 |
| Liam Neeson | Himself | "Fighting Irish" Episode 17 |
| Michael Bublé | Bublé wrap | "Take My Wife" Episode 18 |
| Sanaa Lathan | Donna Tubbs-Brown | "Take My Wife" Episode 18 |
$^*$Live-action role $^#$Archive footage

## Season 14

| Name | Role(s) | Episode |
| Jon Daly | Javier Bardem | "Pilling Them Softly" Episode 1 |
| Sanaa Lathan | Donna Tubbs-Brown | "Pilling Them Softly" Episode 1 |
| Cary Elwes | Charles Dickens | "Papa Has a Rollin' Son" Episode 2 |
| Ed O'Neill | Bud Swanson | "Papa Has a Rollin' Son" Episode 2 |
| John Mellencamp | Himself | "Peternormal Activity" Episode 4 |
| Emily Osment | Hiker Girl in Movie | "Peternormal Activity" Episode 4 |
| Kate McKinnon | Karen Griffin | "Peter's Sister" Episode 6 |
| Belita Moreno | Rosario Vargas | "Peter's Sister" Episode 6 |
| Joe Buck | Himself | "Brokeback Swanson" Episode 8 |
| Margaret Cho | Hee-Sun | "Candy, Quahog Marshmallow" Episode 10 |
| Carrie Fisher | Angela | "Candy, Quahog Marshmallow" Episode 10 |
| Sung Kang | Soap opera actor | "Candy, Quahog Marshmallow" Episode 10 |
| Ashton Kutcher | Himself | "Candy, Quahog Marshmallow" Episode 10 |
| C.S. Lee | Soap opera actor | "Candy, Quahog Marshmallow" Episode 10 |
| Chad L. Coleman | African gunman | "Scammed Yankees" Episode 12 |
| Neil deGrasse Tyson | Himself | "Scammed Yankees" Episode 12 |
| Martha MacIsaac | Patty | "Scammed Yankees" Episode 12 |
| Christina Milian | Esther | "Scammed Yankees" Episode 12 |
| Tia Carrere | Hawaiian woman | "An App a Day" Episode 13 |
| Kate McKinnon | Philippa | "An App a Day" Episode 13 |
| Carl Reiner | Old man | "An App a Day" Episode 13 |
| Jon Daly | Oliver Platt | "Underage Peter" Episode 14 |
| Cary Elwes | Edison's assistant | "Underage Peter" Episode 14 |
| Julie Hagerty | Carol West | "Underage Peter" Episode 14 |
| Jay Leno | Mayor Jay Leno | "Underage Peter" Episode 14 |
| Glenn Close | Herself | "A Lot Going on Upstairs" Episode 15 |
| Breckin Meyer | S&M guy | "A Lot Going on Upstairs" Episode 15 |
| Mary Kay Place | Farting lady | "The Heartbreak Dog" Episode 16 |
| Katharine Ross | Mrs. Abbott | "The Heartbreak Dog" Episode 16 |
| Paget Brewster | Gretchen Mercer | "Take A Letter" Episode 17 |
| Ken Marino | Dallas Portland | "The New Adventures of Old Tom" Episode 18 |
| Simon Cowell | Himself | "Run, Chris, Run" Episode 19 |
| Liam Payne | Himself | "Run, Chris, Run" Episode 19 |
| Louis Tomlinson | Himself | "Run, Chris, Run" Episode 19 |
| Barkhad Abdi | Abduwali Muse | "Road to India" Episode 20 |
| Rob Huebel | Business meeting leader | "Road to India" Episode 20 |
| Anil Kapoor | Himself | "Road to India" Episode 20 |
| Russell Peters | Padma's father | "Road to India" Episode 20 |
| Sheetal Sheth | Padma Tapeworm | "Road to India" Episode 20 |
$^*$Live-action role

## Season 15

| Name | Role(s) | Episode |
| Nicole Byer | Airport security worker | "The Boys in the Band" Episode 1 |
| Jenna Lamia | Mrs. Wong | "The Boys in the Band" Episode 1 |
| Nolan North | The Turtlenecks | "The Boys in the Band" Episode 1 |
| Amy Schumer | Crew leader | "The Boys in the Band" Episode 1 |
| Tony Sirico | Vinny | "The Boys in the Band" Episode 1 |
| Kyle Chandler | Coach Doyle | "Bookie of the Year" Episode 2 |
| Frank Sinatra Jr. | Himself | "Bookie of the Year" Episode 2 |
| Kelen Coleman | Woman #3 Hooker #2 | "American Gigg-olo" Episode 3 |
| Gary Newman | Himself | "Inside Family Guy" Episode 4 |
| David Tennant | The Doctor | "Inside Family Guy" Episode 4 |
| Dana Walden | Herself | "Inside Family Guy" Episode 4 |
| James Woods | Himself | "Inside Family Guy" Episode 4 |
| Mark-Paul Gosselaar | Zack Morris | "Chris Has Got a Date, Date, Date, Date, Date" Episode 5 |
| Sean Penn | Himself | "Hot Shots" Episode 6 |
| Heléne Yorke | Waitress | "High School English" Episode 7 |
| Carrie Fisher | Angela | "Carter and Tricia" Episode 8 |
| David Lynch | Himself | "How the Griffin Stole Christmas" Episode 9 |
| Kate McKinnon | Farmer's date | "How the Griffin Stole Christmas" Episode 9 |
| Ty Simpkins | Little Drummer Boy | "How the Griffin Stole Christmas" Episode 9 |
| Stephen Curry | Himself | "Passenger Fatty-Seven" Episode 10 |
| Sanaa Lathan | Donna Tubbs-Brown | "Passenger Fatty-Seven" Episode 10 |
| Chris Gronkowski | Themselves | "Gronkowsbees" Episode 11 |
| Dan Gronkowski | Themselves | "Gronkowsbees" Episode 11 |
| Glenn Gronkowski | Themselves | "Gronkowsbees" Episode 11 |
| Rob Gronkowski | Themselves | "Gronkowsbees" Episode 11 |
| Flea | Himself | "Peter's Def Jam" Episode 12 |
| Marlee Matlin | Stella | "Peter's Def Jam" Episode 12 |
| Carrot Top | Himself | "The Finer Strings" Episode 13 |
| Colin Ford | Football player | "The Finer Strings" Episode 13 |
| Martha MacIsaac | Patty | "The Finer Strings" Episode 13 |
| Kiff VandenHeuvel | Sheriff Woody | "The Finer Strings" Episode 13 |
| Ed Westwick | Football player Wedding officiant | "The Finer Strings" Episode 13 |
| Robert Wu | Mr. Washee-Washee | "The Finer Strings" Episode 13 |
| Christina Pickles | Queen Elizabeth II | "The Dating Game" Episode 14 |
| Heléne Yorke | Sandra | "The Dating Game" Episode 14 |
| Nat Faxon | Coach Herrera | "Cop and a Half-Wit" Episode 15 |
| Ana Ortiz | Maid | "Cop and a Half-Wit" Episode 15 |
| Heléne Yorke | Schwarzenegger's Target Date | "Cop and a Half-Wit" Episode 15 |
| Neil Brown Jr. | Athlete with money | "Saturated Fat Guy" Episode 16 |
| Martha MacIsaac | Patty | "Saturated Fat Guy" Episode 16 |
| Christina Milian | Esther | "Saturated Fat Guy" Episode 16 |
| Wade Boggs | Himself | "Peter's Lost Youth" Episode 17 |
| Lenny Clarke | Fantasy baseball coach | "Peter's Lost Youth" Episode 17 |
| Carrie Fisher | Angela | "Peter's Lost Youth" Episode 17 |
| Carl Reiner | Fantasy baseball coach | "Peter's Lost Youth" Episode 17 |
| Colin Ford | Kid | "The Peter Principal" Episode 18 |
| Jermaine Fowler | Kid | "The Peter Principal" Episode 18 |
| Anders Holm | Superintendent | "The Peter Principal" Episode 18 |
| Shawn Michael Howard | New Orleans band | "The Peter Principal" Episode 18 |
| Martha MacIsaac | Patty | "The Peter Principal" Episode 18 |
| Christina Milian | Esther | "The Peter Principal" Episode 18 |
| Wendy Schaal | Secretary | "The Peter Principal" Episode 18 |
| Kiernan Shipka | Meg's Bully/Singing cheerleader | "The Peter Principal" Episode 18 |
| Lisa Wilhoit | Connie D'Amico | "The Peter Principal" Episode 18 |
| Daniele Gaither | Traffic violations officer | "Dearly Deported" Episode 19 |
| Aimee Garcia | Isabella | "Dearly Deported" Episode 19 |
| Portia de Rossi | Bonnie Swanson's prank call voice | "A House Full of Peters" Episode 20 |
| Sanaa Lathan | Donna Tubbs-Brown | "A House Full of Peters" Episode 20 |
| Olesya Rulin | Russian Meg Griffin | "A House Full of Peters" Episode 20 |
$^F$This marked Frank Sinatra Jr.'s final film/television role.

## Season 16

| Name | Role(s) | Episode |
| Asa Akira | Herself | "Emmy-Winning Episode" Episode 1 |
| Julie Bowen | Herself | "Emmy-Winning Episode" Episode 1 |
| Ty Burrell | Himself | "Emmy-Winning Episode" Episode 1 |
| Frances Callier | Shonda Rhimes | "Emmy-Winning Episode" Episode 1 |
| Louis C.K. | Himself | "Emmy-Winning Episode" Episode 1 |
| Jonathan Kite | Alec Baldwin | "Emmy-Winning Episode" Episode 1 |
| Bill Maher | Himself | "Emmy-Winning Episode" Episode 1 |
| Miriam Margolyes | Maggie Smith's right eyeball | "Emmy-Winning Episode" Episode 1 |
| Ryan O'Neal | Tim Madden | "Emmy-Winning Episode" Episode 1 |
| Christina Pickles | Maggie Smith's left eyeball | "Emmy-Winning Episode" Episode 1 |
| Sofía Vergara | Herself | "Emmy-Winning Episode" Episode 1 |
| Chris Diamantopoulos | Stryker Foxx | "Foxx in the Men House" Episode 2 |
| Ignacio Serricchio | Jonathan Goldsmith | "Foxx in the Men House" Episode 2 |
| Kathleen Turner | Peter Griffin | "Foxx in the Men House" Episode 2 |
| Chris Diamantopoulos | Fievel Mousekewitz | "Nanny Goats" Episode 3 |
| Sanaa Lathan | Donna Tubbs-Brown | "Nanny Goats" Episode 3 |
| Ryan Reynolds | Himself | "Follow the Money" Episode 4 |
| Carrie Fisher | Angela | "Three Directors" Episode 5 |
| Kristen Bell | Martha | "Petey IV" Episode 7 |
| Jeff Probst | Himself | "Petey IV" Episode 7 |
| Iwan Rheon | George Harrison John Lennon Ring announcer | "Petey IV" Episode 7 |
| Carrie Fisher | Angela | "Don't Be a Dickens at Christmas" Episode 9 |
| Norm MacDonald | Himself | "Don't Be a Dickens at Christmas" Episode 9 |
| David Mazouz | Peter's co-worker | "Don't Be a Dickens at Christmas" Episode 9 |
| Jay Pharaoh | Kanye Canes | "Don't Be a Dickens at Christmas" Episode 9 |
| Don Swayze | Patrick Swayze | "Don't Be a Dickens at Christmas" Episode 9 |
| Amanda Seyfried | Ellie | "Boy (Dog) Meets Girl (Dog)" Episode 10 |
| Dikembe Mutombo | Himself | "Dog Bites Bear" Episode 11 |
| Danny Trejo | Himself | "Dog Bites Bear" Episode 11 |
| Ian McKellen | Dr. Cecil Pritchfield | "Send in Stewie, Please" Episode 12 |
| Tom Ellis | Oscar Wilde | "V is for Mystery" Episode 13 |
| Tom Hollander | Distinguished man #2 | "V is for Mystery" Episode 13 |
| Eric Dane | Himself | "Veteran Guy" Episode 14 |
| Kenny Loggins | Himself | "Veteran Guy" Episode 14 |
| Tom Cochrane | Himself | "The Woof of Wall Street" Episode 15 |
| Esther Ku | Secretary | "The Woof of Wall Street" Episode 15 |
| Sanaa Lathan | Donna Tubbs-Brown | "'Family Guy' Through the Years" Episode 16 |
| Chris Diamantopoulos | Parker Stanton | "HTTPete" Episode 18 |
| Ignacio Serricchio | Pitbull | "The Unkindest Cut" Episode 19 |
| Pej Vahdat | Middle Eastern co-pilot | "The Unkindest Cut" Episode 19 |
$^*$Live-action role $^#$Archive footage $^†$Uncredited $^C$This would be Carrie Fisher's final television appearance, following her death in 2016.

## Season 17

| Name | Role(s) | Episode |
| Sanaa Lathan | Fangirl | "Married with Cancer" Episode 1 |
| Jay Pharaoh | Kanye West | "Married with Cancer" Episode 1 |
| Casey Wilson | Jess | "Married with Cancer" Episode 1 |
| Casey Wilson | Jess | "Dead Dog Walking" Episode 2 |
| Eva Bella | Kid | "Pal Stewie" Episode 3 |
| Aries Spears | Eddie Murphy | "Pal Stewie" Episode 3 |
| Gilbert Gottfried | Dog whistle | "Big Trouble in Little Quahog" Episode 4 |
| Kyrie Irving | Vernon the Waterbear | "Big Trouble in Little Quahog" Episode 4 |
| Patrick Stewart | Patrick the Waterbear | "Big Trouble in Little Quahog" Episode 4 |
| Aries Spears | Shaquille O'Neal | "Regarding Carter" Episode 5 |
| Kimberly Brooks | Black sitcom mom | "Stand by Meg" Episode 6 |
| Scott Grimes | Kevin Swanson | "Stand by Meg" Episode 6 |
| Tara Lipinski | Herself | "The Griffin Winter Games" Episode 7 |
| Ross Marquand | Garth Brooks | "The Griffin Winter Games" Episode 7 |
| Jim Meskimen | Ron Howard | "The Griffin Winter Games" Episode 7 |
| Christine Baranski | Newport heiress | "Con Heiress" Episode 8 |
| Sanaa Lathan | Donna Tubbs-Brown | "Con Heiress" Episode 8 |
| Christina Pickles | Newport heiress | "Con Heiress" Episode 8 |
| Wendy Schaal | Newport heiress | "Con Heiress" Episode 8 |
| Bryan Cranston | Bert | "Pawtucket Pete" Episode 9 |
| Billy Eichner | Himself | "Pawtucket Pete" Episode 9 |
| Andrew Kishino | Goose | "Pawtucket Pete" Episode 9 |
| Sanaa Lathan | Fangirl | "Pawtucket Pete" Episode 9 |
| Niecy Nash | Sheila | "Pawtucket Pete" Episode 9 |
| Tara Strong | Fangirl | "Pawtucket Pete" Episode 9 |
| Ross Marquand | George H. W. Bush Johnny Depp | "Trump Guy" Episode 11 |
| Charlet Chung | Brittany hologram | "Bri, Robot" Episode 12 |
| Bryan Cranston | Bert | "Trans-Fat" Episode 13 |
| Niecy Nash | Sheila | "Trans-Fat" Episode 13 |
| Maurice LaMarche | Conan O'Brien | "Trans-Fat" Episode 13 |
| Bryan Cranston | Bert | "Family Guy Lite" Episode 14 |
| Sanaa Lathan | Donna Tubbs-Brown | "Family Guy Lite" Episode 14 |
| Ross Marquand | Slinky | "Family Guy Lite" Episode 14 |
| Niecy Nash | Sheila | "Family Guy Lite" Episode 14 |
| Mandy Moore | Courtney | "No Giggity, No Doubt" Episode 15 |
| Casey Wilson | Gymnastics team mom | "No Giggity, No Doubt" Episode 15 |
| Chris Parnell | Priest | "You Can't Handle the Booth" Episode 16 |
| Sarah Paulson | Herself Marcia Clark Costumed woman | "You Can't Handle the Booth" Episode 16 |
| Judy Greer | Luna Bar lover Middle-aged woman | "Island Adventure" Episode 17 |
| Chris Parnell | Doug | "Island Adventure" Episode 17 |
| Christine Lakin | Joyce Kinney Quagmire's Date | "Throw It Away" Episode 18 |
| Sanaa Lathan | Donna Tubbs-Brown Backup singer | "Throw It Away" Episode 18 |
| Sam Elliott | Himself | "Girl, Internetted" Episode 19 |
| Denis Leary | Car mechanic | "Girl, Internetted" Episode 19 |
| Julie Hagerty | Carol Pewterschmidt | "Adam West High" Episode 20 |
$^†$Uncredited

## Season 18

| Name | Role(s) | Episode |
| Bryan Cranston | Bert | "Yacht Rocky" Episode 1 |
| Lucas Grabeel | Chad | "Yacht Rocky" Episode 1 |
| Sanaa Lathan | Donna Tubbs-Brown | "Yacht Rocky" Episode 1 |
| Kenny Loggins | Himself | "Yacht Rocky" Episode 1 |
| Niecy Nash | Sheila | "Yacht Rocky" Episode 1 |
| Alan Parsons | Himself | "Yacht Rocky" Episode 1 |
| Nick Viall | Himself | "Yacht Rocky" Episode 1 |
| Carlos Alazraqui | Chef | "Bri-Da" Episode 2 |
| Eugene Byrd | Ups Deliveryman | "Bri-Da" Episode 2 |
| Bryan Cranston | Bert | "Bri-Da" Episode 2 |
| Scott Grimes | Kevin Swanson | "Bri-Da" Episode 2 |
| Robert Herjavec | Himself | "Bri-Da" Episode 2 |
| Bryan Cranston | Bert | "Disney's The Reboot" Episode 4 |
| Judy Greer | Herself | "Disney's The Reboot" Episode 4 |
| Martha MacIsaac | Patty | "Disney's The Reboot" Episode 4 |
| Emily Osment | Ruth Cochamer | "Disney's The Reboot" Episode 4 |
| Gary Newman | Himself | "Disney's The Reboot" Episode 4 |
| Chris Parnell | Smarmy J. Tiestraightener III | "Disney's The Reboot" Episode 4 |
| Dana Walden | Herself | "Disney's The Reboot" Episode 4 |
| Daisy Fuentes | Herself | "Peter & Lois' Wedding" Episode 6 |
| Mike Judge | Beavis and Butt-Head | "Peter & Lois' Wedding" Episode 6 |
| Carlos Alazraqui | Warden | "Shanksgiving" Episode 8 |
| Hank Azaria | Police Superintendent Chalmers | "Shanksgiving" Episode 8 |
| Nat Faxon | Neo-Nazi | "Shanksgiving" Episode 8 |
| Danny Trejo | Clint Beltran | "Shanksgiving" Episode 8 |
| Jimmy Connors | Himself | "Christmas is Coming" Episode 9 |
| Chris Parnell | Subway Manager | "Christmas is Coming" Episode 9 |
| Lisa Wilhoit | Connie D'Amico | "Connie's Celica" Episode 10 |
| Christopher Meloni | George Townshend | "Short Cuts" Episode 11 |
| Dan Castellaneta | Homer Simpson | "The Movement" Episode 14 |
| Jerry Lambert | Man Congratulating Peter | "The Movement" Episode 14 |
| Kevin Nealon | Himself | "The Movement" Episode 14 |
| Khary Payton | King Baseball Player | "The Movement" Episode 14 |
| Alex Pettyfer | Troy | "The Movement" Episode 14 |
| Brett Gelman | Escape Room Guy | "Baby Stewie" Episode 15 |
| Judy Greer | Bozo's Client Sylvester Stallone's Assistant | "Baby Stewie" Episode 15 |
| Robert Wu | Korean General | "Baby Stewie" Episode 15 |
| Bryan Cranston | Bert Judge | "Start Me Up" Episode 16 |
| Martha MacIsaac | Airport Announcer | "Start Me Up" Episode 16 |
| Ross Marquand | Indiana Jones Jesse Eisenberg | "Start Me Up" Episode 16 |
| Khary Payton | Abusive Father | "Start Me Up" Episode 16 |
| Dan Castellaneta | Homer Simpson | "Coma Guy" Episode 17 |
| Alfred Molina | Panamanian Man | "Coma Guy" Episode 17 |
| Carlos Alazraqui | Chief Justice John Roberts | "Better Off Meg" Episode 18 |
| Lucas Grabeel | Student | "Better Off Meg" Episode 18 |
| Ali Hillis | Meg's Friend | "Better Off Meg" Episode 18 |
| Esther Ku | Meg's Friend | "Better Off Meg" Episode 18 |
| Kristen Li | Funeral Girl #1 | "Better Off Meg" Episode 18 |
| Chris Parnell | Priest Father Raccoon | "Better Off Meg" Episode 18 |
| Stephanie Beatriz | Hostess | "Holly Bibble" Episode 19 |
| Edie McClurg | Herself as Grace | "Holly Bibble" Episode 19 |
| Liam McIntyre | Wombat | "Holly Bibble" Episode 19 |
| Chris Parnell | Highway Man | "Holly Bibble" Episode 19 |
| Allison Munn | Suits Actress Accused Witch Autograph Seeker | "Movin' In (Principal Shepherd's Song)" Episode 20 |
| Chris Parnell | Doug | "Movin' In (Principal Shepherd's Song)" Episode 20 |
| Ignacio Serricchio | Lawnmower Guy | "Movin' In (Principal Shepherd's Song)" Episode 20 |