# 2021 Prague Open – Singles

Simona Halep was the defending champion, but chose not to participate.
Barbora Krejčíková won the title, defeating Tereza Martincová in the final, 6–2, 6–0.

## Seeds

* Petra Kvitová (first round)
* Barbora Krejčíková (champion)
* Markéta Vondroušová (withdrew)
* Marie Bouzková (first round)
* Kateřina Siniaková (quarterfinals)
* Hsieh Su-wei (withdrew)
* Nina Stojanović (second round)
* Tereza Martincová (final)
* Greet Minnen (semifinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 8 | Tereza Martincová | 6 | 6 | | | | |
| 9 | Greet Minnen | 3 | 4 | | | | |
| 9 | Greet Minnen | 3 | 4 | 8 | Tereza Martincová | 2 | 0 |
| | | | | 2 | Barbora Krejčíková | 6 | 6 |
| | Wang Xinyu | 1 | 2 | 2 | Barbora Krejčíková | 6 | 6 |
| 2 | Barbora Krejčíková | 6 | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | P Kvitová | 6$^5$ | 6 | 4 | | | | | | | | | | | | | |
| Q | R Šramková | 7$^7$ | 3 | 6 | Q | R Šramková | 4 | 5 | | | | | | | | | |
| | M Barthel | 6 | 4 | 3 | WC | V Kužmová | 6 | 7 | | | | | | | | | |
| WC | V Kužmová | 2 | 6 | 6 | | | | | | WC | V Kužmová | 2 | 2 | | | | |
| | L Cabrera | 6 | 2 | 2 | | | | | | 8 | T Martincová | 6 | 6 | | | | |
| Q | A Muhammad | 3 | 6 | 6 | Q | A Muhammad | 3 | 4 | | | | | | | | | |
| PR | S Murray Sharan | 1 | 4 | | 8 | T Martincová | 6 | 6 | | | | | | | | | |
| 8 | T Martincová | 6 | 6 | | | | | | | | | | | 8 | T Martincová | 6 | 6 |
| 4 | M Bouzková | 6 | 4 | 2 | | | | | | | | | | 9 | G Minnen | 3 | 4 |
| | S Sanders | 3 | 6 | 6 | | S Sanders | 4 | 6 | 6 | | | | | | | | |
| Q | U Radwańska | 6 | 3 | 1 | | N Párrizas Díaz | 6 | 3 | 1 | | | | | | | | |
| | N Párrizas Díaz | 2 | 6 | 6 | | | | | | | S Sanders | 2 | 1 | | | | |
| LL | A Gasanova | 6 | 4 | 6 | | | | | | 9 | G Minnen | 6 | 6 | | | | |
| WC | L Havlíčková | 2 | 6 | 4 | LL | A Gasanova | 3 | 6$^3$ | | | | | | | | | |
| | G Gatto-Monticone | 0 | 6 | 1 | 9 | G Minnen | 6 | 7$^7$ | | | | | | | | | |
| 9 | G Minnen | 6 | 4 | 6 | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | N Stojanović | 6$^5$ | 6 | 6 | | | | | | | | | | | | | |
| PR | V Diatchenko | 7$^7$ | 1 | 3 | 7 | N Stojanović | 6 | 1 | 4 | | | | | | | | |
| WC | S Stosur | 3 | 6 | 3 | | G Min | 3 | 6 | 6 | | | | | | | | |
| | G Min | 6 | 2 | 6 | | | | | | | G Min | 3 | 3 | | | | |
| | L Küng | 2 | 2 | | | | | | | | Xin Wang | 6 | 6 | | | | |
| | Xin Wang | 6 | 6 | | | Xin Wang | 3 | 7 | 6 | | | | | | | | |
| LL | C Perrin | 3 | 4 | | LL | E-s Liang | 6 | 5 | 1 | | | | | | | | |
| LL | E-s Liang | 6 | 6 | | | | | | | | | | | | Xin Wang | 1 | 2 |
| 5 | K Siniaková | 6 | 6 | | | | | | | | | | | 2 | B Krejčíková | 6 | 6 |
| Q | J Burrage | 0 | 4 | | 5 | K Siniaková | 2 | 7$^7$ | 6 | | | | | | | | |
| | M Inglis | 2 | 2 | | PR | T Smitková | 6 | 6$^3$ | 3 | | | | | | | | |
| PR | T Smitková | 6 | 6 | | | | | | | 5 | K Siniaková | 3 | 0 | | | | |
| Q | N Bains | 3 | 2 | | | | | | | 2 | B Krejčíková | 6 | 6 | | | | |
| | Y Bonaventure | 6 | 6 | | | Y Bonaventure | 6$^2$ | 4 | | | | | | | | | |
| Q | I Shinikova | 2 | 3 | | 2 | B Krejčíková | 7$^7$ | 6 | | | | | | | | | |
| 2 | B Krejčíková | 6 | 6 | | | | | | | | | | | | | | |

## Qualifying
### Seeds

* Anastasia Gasanova (qualifying competition; Lucky loser)
* Asia Muhammad (qualified)
* Isabella Shinikova (qualified)
* Samantha Murray Sharan (moved to the main draw)
* Rebecca Šramková (qualified)
* Urszula Radwańska (qualified)
* Conny Perrin (qualifying competition; Lucky loser)
* Liang En-shuo (qualifying competition; Lucky loser)
* Anastasia Zakharova (qualifying competition)
* Jodie Burrage (qualified)
* Yuan Yue (qualifying competition)
* Naiktha Bains (qualified)

### Qualifiers

* Jodie Burrage
* Asia Muhammad
* Isabella Shinikova
* Naiktha Bains
* Rebecca Šramková
* Urszula Radwańska

### Lucky losers

* Conny Perrin
* Anastasia Gasanova
* Liang En-shuo

### Draw
#### First qualifier

| First round | First round | First round | First round | Qualifying competition | Qualifying competition | Qualifying competition | Qualifying competition |
| 1 | Anastasia Gasanova | 6 | 6 | | | | |
| | María Lourdes Carlé | 1 | 3 | | | | |
| | María Lourdes Carlé | 1 | 3 | 1 | Anastasia Gasanova | 1 | 1 |
| | | | | 10 | Jodie Burrage | 6 | 6 |
| WC | Patricie Kubíková | 5 | 1 | 10 | Jodie Burrage | 6 | 6 |
| 10 | Jodie Burrage | 7 | 6 | | | | |

#### Second qualifier

| First round | First round | First round | First round | Qualifying competition | Qualifying competition | Qualifying competition | Qualifying competition |
| 2 | Asia Muhammad | 6 | 6 | | | | |
| WC | Denisa Hindová | 2 | 0 | | | | |
| WC | Denisa Hindová | 2 | 0 | 2 | Asia Muhammad | 6 | 7 |
| | | | | 9 | Anastasia Zakharova | 3 | 5 |
| WC | Linda Klimovičová | 2 | 5 | 9 | Anastasia Zakharova | 3 | 5 |
| 9 | Anastasia Zakharova | 6 | 7 | | | | |

#### Third qualifier

| First round | First round | First round | First round | Qualifying competition | Qualifying competition | Qualifying competition | Qualifying competition |
| 3 | Isabella Shinikova | 6 | 7 | | | | |
| | Riya Bhatia | 2 | 5 | | | | |
| | Riya Bhatia | 2 | 5 | 3 | Isabella Shinikova | 6 | 6 |
| | | | | 7 | Conny Perrin | 2 | 2 |
| | Miriam Kolodziejová | 2 | 3 | 7 | Conny Perrin | 2 | 2 |
| 7 | Conny Perrin | 6 | 6 | | | | |

#### Fourth qualifier

| First round | First round | First round | First round | Qualifying competition | Qualifying competition | Qualifying competition | Qualifying competition |
| | | | | WC | Tereza Valentová | 2 | 2 |
| | | | | 12 | Naiktha Bains | 6 | 6 |
| WC | Barbora Miklová | 1 | 0$^r$ | 12 | Naiktha Bains | 6 | 6 |
| 12 | Naiktha Bains | 6 | 0 | | | | |

#### Fifth qualifier

| First round | First round | First round | First round | Qualifying competition | Qualifying competition | Qualifying competition | Qualifying competition |
| 5 | Rebecca Šramková | 6 | 6 | | | | |
| WC | Barbora Palicová | 1 | 4 | | | | |
| WC | Barbora Palicová | 1 | 4 | 5 | Rebecca Šramková | 6 | 6 |
| | | | | 11 | Yuan Yue | 3 | 2 |
| | Tara Moore | 5 | 6$^9$ | 11 | Yuan Yue | 3 | 2 |
| 11 | Yuan Yue | 7 | 7$^{11}$ | | | | |

#### Sixth qualifier

| First round | First round | First round | First round | Qualifying competition | Qualifying competition | Qualifying competition | Qualifying competition |
| 6 | Urszula Radwańska | 6 | 6 | | | | |
| WC | Dominika Šalková | 1 | 1 | | | | |
| WC | Dominika Šalková | 1 | 1 | 6 | Urszula Radwańska | 6 | 6 |
| | | | | 8/PR | Liang En-shuo | 2 | 4 |
| | Emina Bektas | 3 | 3 | 8/PR | Liang En-shuo | 2 | 4 |
| 8/PR | Liang En-shuo | 6 | 6 | | | | |