# 2021 MUSC Health Women's Open – Singles

Astra Sharma won her first WTA Tour singles title, defeating Ons Jabeur in the final of the second 2021 Charleston Open, 2–6, 7–5, 6–1.
The second tournament was the 50th edition of the Charleston Open that featured featuring consecutive events, with the 2021 Volvo Car Open being the first. The second Charleston tournament was organised with a single-year license in 2021.

## Seeds

* Ons Jabeur (final)
* Magda Linette (first round)
* Shelby Rogers (quarterfinals)
* Alizé Cornet (first round, retired)
* Misaki Doi (first round, retired)
* Ajla Tomljanović (second round)
* Lauren Davis (second round)
* Madison Brengle (second round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| 1 | Ons Jabeur | 6 | 6 | | | | | |
| | Danka Kovinić | 3 | 0 | | | | | |
| | Danka Kovinić | 3 | 0 | 1 | Ons Jabeur | 6 | 5 | 1 |
| | | | | | Astra Sharma | 2 | 7 | 6 |
| | Astra Sharma | 7$^7$ | 6 | | Astra Sharma | 2 | 7 | 6 |
| SE | Camila Osorio | 6$^5$ | 1 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | O Jabeur | 6 | 6 | | | | | | | | | | | | | | |
| | S Vögele | 4 | 1 | | 1 | O Jabeur | 6 | 6 | | | | | | | | | |
| Q | A Parks | 6 | 6 | | Q | A Parks | 4 | 0 | | | | | | | | | |
| Q | G Min | 1 | 4 | | | | | | | 1 | O Jabeur | 6 | 6 | | | | |
| | K Ahn | 6$^6$ | 2 | | | | | | | | N Hibino | 0 | 1 | | | | |
| | F Di Lorenzo | 7$^8$ | 6 | | | F Di Lorenzo | 4 | 3 | | | | | | | | | |
| | N Hibino | 7 | 5 | 6 | | N Hibino | 6 | 6 | | | | | | | | | |
| 5 | M Doi | 5 | 7 | 6$^r$ | | | | | | | | | | 1 | O Jabeur | 6 | 6 |
| 3 | S Rogers | 6 | 6 | | | | | | | | | | | | D Kovinić | 3 | 0 |
| | C McNally | 0 | 1 | | 3 | S Rogers | 6 | 6 | | | | | | | | | |
| Q | C Liu | 7 | 4 | 6 | Q | C Liu | 2 | 2 | | | | | | | | | |
| Q | S Sanders | 5 | 6 | 0 | | | | | | 3 | S Rogers | 5 | 1 | | | | |
| | D Kovinić | 6 | 6 | | | | | | | | D Kovinić | 7 | 6 | | | | |
| | V Tomova | 3 | 3 | | | D Kovinić | 6 | 1 | 6 | | | | | | | | |
| WC | C Vandeweghe | 6$^3$ | 4 | | 7 | L Davis | 1 | 6 | 3 | | | | | | | | |
| 7 | L Davis | 7$^7$ | 6 | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 8 | M Brengle | 6 | 3 | 6 | | | | | | | | | | | | | |
| | N Vikhlyantseva | 0 | 6 | 2 | 8 | M Brengle | 4 | 6 | 5 | | | | | | | | |
| | Y Wang | 4 | 2 | | | A Sharma | 6 | 4 | 7 | | | | | | | | |
| | A Sharma | 6 | 6 | | | | | | | | A Sharma | 6 | 6 | | | | |
| | T Martincová | 3 | 2$^r$ | | | | | | | WC | L Fruhvirtová | 4 | 3 | | | | |
| WC | E Navarro | 6 | 3 | | WC | E Navarro | 4 | 2 | | | | | | | | | |
| WC | L Fruhvirtová | 6 | 6$^7$ | 4 | WC | L Fruhvirtová | 6 | 6 | | | | | | | | | |
| 4 | A Cornet | 2 | 7$^9$ | 4$^r$ | | | | | | | | | | | A Sharma | 7$^7$ | 6 |
| 6 | A Tomljanović | 6 | 6 | | | | | | | | | | | SE | C Osorio | 6$^5$ | 1 |
| | R Zarazúa | 1 | 1 | | 6 | A Tomljanović | 1 | 4 | | | | | | | | | |
| | C Tauson | 6 | 6 | | | C Tauson | 6 | 6 | | | | | | | | | |
| | L Samsonova | 3 | 3 | | | | | | | | C Tauson | 4 | 0$^r$ | | | | |
| | C McHale | 7$^7$ | 6 | | | | | | | SE | C Osorio | 6 | 1 | | | | |
| | S Errani | 6$^3$ | 3 | | | C McHale | 6 | 6$^2$ | 6$^1$ | | | | | | | | |
| SE | C Osorio | 6 | 4 | 7 | SE | C Osorio | 2 | 7$^7$ | 7$^7$ | | | | | | | | |
| 2 | M Linette | 3 | 6 | 5 | | | | | | | | | | | | | |

## Qualifying
### Seeds

* Renata Zarazúa (moved to main draw)
* Natalia Vikhlyantseva (moved to main draw)
* Francesca Di Lorenzo (moved to main draw)
* Leonie Küng (first round)
* Caroline Dolehide (first round)
* Usue Maitane Arconada (first round)
* Kurumi Nara (qualifying competition)
* Arina Rodionova (withdrew)

### Qualifiers

* Claire Liu
* Storm Sanders
* Alycia Parks
* Grace Min

### Draw
#### First qualifier

| First round | First round | First round | First round | First round | Qualifying competition | Qualifying competition | Qualifying competition | Qualifying competition | Qualifying competition |
| Alt | Hailey Baptiste | 4 | 0$^r$ | | | | | | |
| | Claire Liu | 6 | 3 | | | | | | |
| | Claire Liu | 6 | 3 | | | Claire Liu | 2 | 6 | 6 |
| | | | | | Alt | Ellen Perez | 6 | 4 | 0 |
| Alt | Ellen Perez | 6$^1$ | 7$^7$ | 7 | Alt | Ellen Perez | 6 | 4 | 0 |
| 6 | Usue Maitane Arconada | 7$^7$ | 6$^1$ | 5 | | | | | |

#### Second qualifier

| First round | First round | First round | First round | Qualifying competition | Qualifying competition | Qualifying competition | Qualifying competition |
| Alt | Katharina Gerlach | 3 | 2 | | | | |
| | Storm Sanders | 6 | 6 | | | | |
| | Storm Sanders | 6 | 6 | | Storm Sanders | 7$^7$ | 6 |
| | | | | 7 | Kurumi Nara | 6$^4$ | 2 |
| | Whitney Osuigwe | 2 | 0 | 7 | Kurumi Nara | 6$^4$ | 2 |
| 7 | Kurumi Nara | 6 | 6 | | | | |

#### Third qualifier

| First round | First round | First round | First round | First round | Qualifying competition | Qualifying competition | Qualifying competition | Qualifying competition | Qualifying competition |
| Alt | Alycia Parks | 6 | 6 | | | | | | |
| PR | Varvara Flink | 3 | 3 | | | | | | |
| PR | Varvara Flink | 3 | 3 | | Alt | Alycia Parks | 3 | 6 | 6 |
| | | | | | Alt | Kateryna Bondarenko | 6 | 3 | 3 |
| WC | Kennedy Shaffer | 1 | 7 | 2 | Alt | Kateryna Bondarenko | 6 | 3 | 3 |
| Alt | Kateryna Bondarenko | 6 | 5 | 6 | | | | | |

#### Fourth qualifier

| First round | First round | First round | First round | First round | Qualifying competition | Qualifying competition | Qualifying competition | Qualifying competition |
| 4 | Leonie Küng | 3 | 4 | | | | | |
| WC | Gabriella Price | 6 | 6 | | | | | |
| WC | Gabriella Price | 6 | 6 | | WC | Gabriella Price | 0 | 4 |
| | | | | | Alt | Grace Min | 6 | 6 |
| Alt | Grace Min | 7$^7$ | 2 | 7 | Alt | Grace Min | 6 | 6 |
| 5 | Caroline Dolehide | 6$^4$ | 6 | 5 | | | | |