# C11orf91

Chromosome 11 open reading frame 91, or C11orf91 is a protein which in humans is encoded by the C11orf91 gene.

## Gene

The C11orf91 gene consists of 5159 nucleotides with an mRNA of approximately 836 base pairs. There is one exon found in the C11orf91 gene.

## mRNA

The cytogenetic band location of C11orf91 is 11p13 and is located on the minus strand of the DNA .

### Conceptual translation

Annotated depiction of the C11orf91 mRNA and amino acid protein sequences.

## Protein

The C11orf91 gene encodes a protein that is 193 amino acids in length. The C11orf91 protein contains a domain of unknown function, DUF5529, that spans nearly the entire protein. RBMX protein binding sites were found to be highly conserved in several structures of human C11orf91 3'UTR and 5' UTR. C11orf91 is rich in serine and proline and poor in valine and asparagine. There is a proline rich region found in the middle of the C11orf91. The human C11orf91 protein is approximately 20 kDal and has an isoelectric point around 9.

### Localization

Human C11orf91 protein is predicted to be localized in vesicles.

### Structure

C11orf91 has two helices located near the C-terminus and no beta sheets.

### Post-translational modifications

C11orf91 has a predicted Protein kinase C (PKC) phosphorylation site, Casein kinase 2 (CK2) phosphorylation site, amidation site, and two predicted serine phosphorylation sites, see Conceptual Translation for post-translational modification site locations.

## Evolution

There are no paralogs of the human C11orf91 protein. The human C11orf91 protein has several orthologs found across eight categories of jawed vertebrates including: aves, testudines, alligators, reptiles, mammals, amphibians, lungfishes, and cartilaginous fishes.
Select Orthologs of C11orf91 :
| Genus and Species | Common Name | Taxonomic Group | Median Date of Divergence (MYA) | Accession Number | Sequence Length (aa) | Sequence Identity to Human Protein (%) | Sequence Similarity to Human Protein (%) |
| Homo sapiens | Human | Primates | 0 | XP_016872542.1 | 193 | 100 | 100 |
| Mus musculus | Mouse | Rodentia | 87 | NP_080910.1 | 194 | 81.7 | 84.3 |
| Equus caballus | Horse | Odd-toed ungulates | 94 | XP_023509601.1 | 191 | 87 | 89.1 |
| Choloepus didactylus | Southern two-toed sloth | Pilosa | 99 | XP_037697448.1 | 191 | 86.2 | 87.2 |
| Phascolarctos cinereus | Koala | Diprotodontia | 160 | XP_020819588.1 | 212 | 67.1 | 70.8 |
| Gopherus evgoodei | Goode's thornscrub tortoise | Testudines | 319 | XP_030417986.1 | 163 | 46.5 | 55.5 |
| Pogona vitticeps | Central bearded dragon | Squamata | 319 | XP_020663275.1 | 168 | 44.3 | 54.7 |
| Sphaerodactylus townsendi | Townsend's least gecko | Squamata | 319 | XP_048340539.1 | 168 | 43 | 51.7 |
| Alligator mississippiensis | American alligator | Crocodilia | 319 | XP_059577366.1 | 157 | 41.4 | 51.2 |
| Tyto alba | Barn owl | Strigiformes | 319 | XP_042641164.1 | 143 | 34.5 | 41.5 |
| Calypte anna | Hummingbird | Apodiformes | 319 | XP_030307391.1 | 146 | 32.3 | 44.6 |
| Gymnogyps californianus | California condor | Accipitriformes | 319 | XP_050754406.1 | 142 | 32.2 | 38.8 |
| Dryobates pubescens | Downy woodpecker | Piciformes | 319 | XP_054027854.1 | 143 | 32.1 | 43.5 |
| Dromaius novaehollandiae | Emu | Struthioniformes | 319 | XP_025967391.1 | 209 | 29.6 | 35.8 |
| Rhinatrema bivittatum | Two-lined caecilians | Caecilidae | 352 | XP_029438087.1 | 144 | 45.1 | 57 |
| Pleurodeles waltl | Iberian ribbed newt | Caudata | 352 | KAJ1177600.1 | 140 | 40.1 | 52.3 |
| Hyla sarda | Sardinian tree frog | Anura | 352 | XP_056384394.1 | 153 | 27.4 | 37 |
| Protopterus annectens | West African lungfish | Lepidosireniformes | 408 | XP_043915714.1 | 173 | 28.5 | 37.4 |
| Pygocentrus nattereri | Red-bellied piranha | Characiformes | 429 | XP_017546298.1 | 147 | 25.9 | 37.1 |
| Amblyraja radiata | Thorny skate | Rajiformes | 462 | XP_032894439.1 | 136 | 37.7 | 46.2 |