# 2022 Savannah Challenger – Singles

Federico Coria was the defending champion but chose not to defend his title.
Jack Sock won the title after defeating Christian Harrison 6–4, 6–1 in the final.

## Seeds

* Tomás Martín Etcheverry (quarterfinals)
* Stefan Kozlov (first round)
* Emilio Gómez (first round, retired)
* Jack Sock (champion)
* Tomás Barrios Vera (first round)
* J. J. Wolf (semifinals)
* Tennys Sandgren (first round)
* Bjorn Fratangelo (semifinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Christian Harrison | 6 | 6 | | | | |
| 6 | J. J. Wolf | 1 | 3 | | | | |
| 6 | J. J. Wolf | 1 | 3 | | Christian Harrison | 4 | 1 |
| | | | | 4 | Jack Sock | 6 | 6 |
| 4 | Jack Sock | 6 | 6 | 4 | Jack Sock | 6 | 6 |
| 8 | Bjorn Fratangelo | 2 | 4 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | TM Etcheverry | 6 | 6 | | | | | | | | | | | | | | |
| Q | A Mayo | 4 | 1 | | 1 | TM Etcheverry | 1 | 6 | 3 | | | | | | | | |
| Q | A Fils | 4 | 6 | 6 | Q | A Fils | 6 | 3 | 0$^r$ | | | | | | | | |
| | N Kuhn | 6 | 1 | 3 | | | | | | 1 | TM Etcheverry | 4 | 2 | | | | |
| | C Harrison | 6 | 6 | | | | | | | | C Harrison | 6 | 6 | | | | |
| Q | Ezekiel Clark | 1 | 3 | | | C Harrison | 6 | 6 | | | | | | | | | |
| | A Galarneau | 6 | 6 | | | A Galarneau | 2 | 3 | | | | | | | | | |
| 7 | T Sandgren | 3 | 1 | | | | | | | | | | | | C Harrison | 6 | 6 |
| 3 | E Gómez | 2 | 4$^r$ | | | | | | | | | | | 6 | J. J. Wolf | 1 | 3 |
| | J Jung | 6 | 4 | | | J Jung | 5 | 4 | | | | | | | | | |
| | A Rybakov | 6 | 6 | | | A Rybakov | 7 | 6 | | | | | | | | | |
| | K Uchida | 3 | 2 | | | | | | | | A Rybakov | 3 | 4 | | | | |
| | M Mmoh | 3 | 1$^r$ | | | | | | | 6 | J. J. Wolf | 6 | 6 | | | | |
| | J Kubler | 6 | 1 | | | J Kubler | 3 | 6 | 2 | | | | | | | | |
| | R Ramanathan | 6$^4$ | 0 | | 6 | J. J. Wolf | 6 | 2 | 6 | | | | | | | | |
| 6 | J. J. Wolf | 7$^7$ | 6 | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 5 | T Barrios Vera | 2 | 6 | 6$^5$ | | | | | | | | | | | | | |
| Q | G Nanda | 6 | 3 | 7$^7$ | Q | G Nanda | 4 | 3 | | | | | | | | | |
| Q | S Kirchheimer | 5 | 3 | | | Zh Zhang | 6 | 6 | | | | | | | | | |
| | Zh Zhang | 7 | 6 | | | | | | | Zh Zhang | 4 | 6 | 3 | | | | |
| | T-l Wu | 2 | 5 | | | | | | 4 | J Sock | 6 | 3 | 6 | | | | |
| | S Nagal | 6 | 7 | | | S Nagal | 3 | 3 | | | | | | | | | |
| | M Torpegaard | 3 | 7$^7$ | 4 | 4 | J Sock | 6 | 6 | | | | | | | | | |
| 4 | J Sock | 6 | 6$^3$ | 6 | | | | | | | | | | 4 | J Sock | 6 | 6 |
| 8 | B Fratangelo | 6 | 6 | | | | | | | | | | | 8 | B Fratangelo | 2 | 4 |
| Alt | M Safwat | 0 | 0 | | 8 | B Fratangelo | 7$^7$ | 6 | | | | | | | | | |
| WC | N Rubin | 2 | 1 | | | G Brouwer | 6$^5$ | 3 | | | | | | | | | |
| | G Brouwer | 6 | 6 | | | | | | 8 | B Fratangelo | 6 | 4 | 7$^7$ | | | | |
| WC | O Crawford | 6 | 6 | | | | | | Q | J Pereira | 2 | 6 | 6$^3$ | | | | |
| WC | L Tien | 3 | 1 | | WC | O Crawford | 4 | 3 | | | | | | | | | |
| Q | J Pereira | 6 | 6 | | Q | J Pereira | 6 | 6 | | | | | | | | | |
| 2 | S Kozlov | 1 | 0 | | | | | | | | | | | | | | |