# International Society for Extracellular Vesicles

The International Society for Extracellular Vesicles (ISEV) is an international scientific organization that focuses on advancing global extracellular vesicle (EV) research. These membrane-bound particles are released from all known cells and include exosomes, ectosomes, exophers, oncosomes, and more. Established in 2011, the society is a nonprofit organization. It is governed by an executive committee. The current president is Kenneth Witwer. Previous presidents were Edit Buzás (2022-2024), Clotilde Théry (2018-2022), Andrew Hill (2016-2018) and founding president Jan Lötvall (2011-2016). The society's journals are the Journal of Extracellular Vesicles and the Journal of Extracellular Biology. ISEV also publishes the international consensus guidelines for EV studies, the "Minimal information for studies of EVs" (MISEV).
ISEV has several committees (Meetings and Programs, Science and Journals, Rigor and Standardization, Education, Translation, Regulation, and Advocacy Committee, and Communications and Membership) focused on advancing research and promoting awareness in the EVs. Each committee has specific roles and goals.

## Meetings

As part of its mission to promote scientific research and education, the society hosts annual meetings and educational event as well as numerous workshops on defined EV-related topics. The society also co-sponsors or endorses related events.
| Annual meeting | Location |
| ISEV2024 | Melbourne, Australia |
| ISEV2023 | Seattle, USA |
| ISEV2022 | Lyon, France |
| ISEV2021 | Virtual Meeting |
| ISEV2020 | Virtual Meeting |
| ISEV2019 | Kyoto, Japan |
| ISEV2018 | Barcelona, Spain |
| ISEV2017 | Toronto, Canada |
| ISEV2016 | Rotterdam, Netherlands |
| ISEV2015 | Washington DC, USA |
| ISEV2014 | Rotterdam, Netherlands |
| ISEV2013 | Boston, USA |
| ISEV2012 | Gothenburg, Sweden |

### Workshops and scientific seminars

ISEV workshops began with a meeting on extracellular RNA (New York City, 2012), and continue to include one to two meetings per year. During widespread restrictions on in-person meetings during the COVID-19 pandemic, ISEV introduced the "Extracellular Vesicle Club," a weekly virtual event featuring presentations and moderated discussion of scientific publications.
| Topic | Location | Year |
| Blood EVs | South Korea | September 2024 |
| Large Extracellular Vesicles | United States | March 2024 |
| EV-based Biomarkers | Denmark | October 2023 |
| Workshop by EV-TRACK Task Force | Virtual | March 2023 |
| The second Urine EV Task Force Virtual Symposium on Urinary Extracellular Vesicles | Virtual | February 2023 |
| QuantitatEVs: Multiscale analyses, from bulk to single vesicle | Rome and Milan | January-February 2023 |
| Blood EVs: an ISEV Workshop | Finland | September 2022 |
| massivEVs Workshop | Italy/Virtually | October 2021 |
| Infectious Diseases Meeting | Virtual | January 2021 |
| EV Imaging in Vivo | France | September 2020 |
| EVs in Immunology | Buenos Aires | March 2020 |
| Open, Reproducible and Standardized EV Research | Belgium | December 2019 |
| EV-based Clinical Theranostics | China | November 2018 |
| Membranes and EVs Workshop | United States | March 2018 |
| Extracellular Vesicles as Biomarkers of Disease | United Kingdom | December 2017 |
| Diet, Environment and Extracellular Vesicles | Australia | January 2017 |
| Cross-Organism Communication by Extracellular Vesicles: Hosts, Microbes, Parasites | Brazil | November 2016 |
| Research Seminar: EV-associated RNA: Is there a purpose? | Netherlands | September 2015 |
| ISEV Workshop on Isolation and Characterization of Extracellular Vesicles | Hungary | October 2013 |
| ISEV RNA Workshop | United States | October 2012 |

### Endorsed or co-sponsored events

The society has directly or indirectly supported EV-related events around the world. These include meetings of the UK, French, and Spanish and Portuguese EV Societies (GEIVEX), a course of the European Molecular Biology Laboratory, Keystone Symposia (2016 and 2018), Gordon Research Conferences (2016, 2018, and 2022), a Cold Spring Harbor Asia Meeting (2016), and others.

## Journal of Extracellular Vesicles, Journal of Extracellular Biology, and standardization initiatives

To disseminate research in the field, the society established the peer-reviewed open access Journal of Extracellular Vesicles in 2012. The journal was initially published by Co-Action Publishing, by Taylor & Francis from 2016-2020, and by Wiley since 2020. In addition to research and review articles, the journal periodically publishes position papers of the society that are meant to advance standardization efforts. In 2014, the Executive Board of Directors published a set of minimal information guidelines for publication of EV studies. These requirements, known as "MISEV" or "MISEV2014," mirrored similar initiatives in the fields of microarray (MIAME) and proteomics (MIAPE) analysis, among others. In 2017, the society's board announced its intent to update these requirements with community involvement. The "MISEV2018" requirements were published in 2018 by Clotilde Théry and Kenneth Witwer with input from 380 co-authors. The current consensus guidelines, known as "MISEV2023", were prepared with input from more than 1050 co-authors, using extensive crowdsourcing of expert opinion to build consensus. The corresponding authors are Joshua Welsh, Deborah Goberdhan, Lorraine O'Driscoll, Clotilde Théry and Kenneth Witwer.
In 2021, ISEV founded a second journal, the Journal of Extracellular Biology, focusing on EVs but also other extracellular particles (EPs) and phenomena. The editor-in-chief is Andrew Hill.

## Education

Among the educational initiatives of the society are massive open online courses (MOOCs), launched in 2016. MOOC 1&II are available through Coursera and co-sponsored by the University of Gothenburg, Pohang University of Science and Technology, and the University of California, Irvine. MOOC III is available on YouTube

## Student Network on Extracellular Vesicles

In 2020, the Student Network on Extracellular Vesicles (SNEV) was founded as a virtual network for early-career researchers in EV research. SNEV’s activities include organizing online scientific talks, a monthly newsletter, industry talks and informal meet-and-greets (coffee catch ups). SNEV has organized two virtual conferences, one in 2021 and the second in 2023. Since 2024, SNEV has become the official early career within ISEV.
[TD1]Link to Student Network on Extracellular Vesicles (wordpress.com)