OpenLLM-France/wikimedia huggingface dataset:
# Ryanodine receptor 2

Ryanodine receptor 2 (RYR2) is one of a class of ryanodine receptors and a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2 gene. In the process of cardiac calcium-induced calcium release, RYR2 is the major mediator for sarcoplasmic release of stored calcium ions.

## Structure

The channel is composed of RYR2 homotetramers and FK506-binding proteins found in a 1:4 stoichiometric ratio. Calcium channel function is affected by the specific type of FK506 isomer interacting with the RYR2 protein, due to binding differences and other factors.

## Function

The RYR2 protein functions as the major component of a calcium channel located in the sarcoplasmic reticulum that supplies ions to the cardiac muscle during systole. To enable cardiac muscle contraction, calcium influx through voltage-gated L-type calcium channels in the plasma membrane allows calcium ions to bind to RYR2 located on the sarcoplasmic reticulum. This binding causes the release of calcium through RYR2 from the sarcoplasmic reticulum into the cytosol, where it binds to the C domain of troponin, which shifts tropomyosin and allows the myosin ATPase to bind to actin, enabling cardiac muscle contraction. RYR2 channels are associated with many cellular functions, including mitochondrial metabolism, gene expression and cell survival, in addition to their role in cardiomyocyte contraction.

## Clinical significance

Deleterious mutations of the ryanodine receptor family, and especially the RYR2 receptor, lead to a constellation of pathologies leading to both acute and chronic heart failure collectively known as "Ryanopathies."
Mutations in the RYR2 gene are associated with catecholaminergic polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.
Recently, sudden cardiac death in several young individuals in the Amish community (four of which were from the same family) was traced to homozygous duplication of a mutant RyR2 gene. Normal (wild type) RyR2 functions primarily in the myocardium (heart muscle).
Mice with genetically reduced RYR2 exhibit a lower basal heart rate and fatal arrhythmias.

## Interactions

Ryanodine receptor 2 has been shown to interact with:
* Protein kinase A (AKAP6, PRKACA, PRKACB, PRKACG,) (phosphorylation at serine position S2808 in rodents)
* CaMKII (via phosphorylation at serine positions S2808 and S2814 in humans and rodents, S2809 and S2815 in rabbits)
* SRI
* Protein phosphatase 1 (dephosphorylation at serine positions S2808 and S2814 in rodents)
* Protein phosphatase 2 (dephosphorylation at serine position S2814 in rodents<ref name = "Huke_2008" / >)
# Rameshki

Rameshki (Russian: Рамешки) is the name of several inhabited localities in Russia.

## Kostroma Oblast

As of 2010, two rural localities in Kostroma Oblast bear this name:
* Rameshki, Kologrivsky District, Kostroma Oblast, a village in Ilyinskoye Settlement of Kologrivsky District
* Rameshki, Nerekhtsky District, Kostroma Oblast, a village in Voskresenskoye Settlement of Nerekhtsky District

## Nizhny Novgorod Oblast

As of 2010, four rural localities in Nizhny Novgorod Oblast bear this name:
* Rameshki, Bolshemurashkinsky District, Nizhny Novgorod Oblast, a village in Kholyazinsky Selsoviet of Bolshemurashkinsky District
* Rameshki, Koverninsky District, Nizhny Novgorod Oblast, a village in Gorevsky Selsoviet of Koverninsky District
* Rameshki, Kstovsky District, Nizhny Novgorod Oblast, a village in Chernyshikhinsky Selsoviet of Kstovsky District
* Rameshki, Sokolsky District, Nizhny Novgorod Oblast, a village in Loyminsky Selsoviet of Sokolsky District

## Tver Oblast

As of 2010, four inhabited localities in Tver Oblast bear this name.

### Urban localities

* Rameshki, Rameshkovsky District, Tver Oblast, an urban-type settlement in Rameshkovsky District

### Rural localities

* Rameshki, Maksatikhinsky District, Tver Oblast, a village in Trestenskoye Rural Settlement of Maksatikhinsky District
* Rameshki, Molokovsky District, Tver Oblast, a village in Molokovskoye Rural Settlement of Molokovsky District
* Rameshki, Sonkovsky District, Tver Oblast, a village in Belyanitskoye Rural Settlement of Sonkovsky District

## Vologda Oblast

As of 2010, two rural localities in Vologda Oblast bear this name:
* Rameshki, Gryazovetsky District, Vologda Oblast, a village in Pertsevsky Selsoviet of Gryazovetsky District
* Rameshki, Nikolsky District, Vologda Oblast, a village in Osinovsky Selsoviet of Nikolsky District
# Aale Tynni

Aale Maria Tynni-Haavio (3 October 1913 – 21 October 1997) was a Finnish poet and translator. She is best known for editing and translating European poetry ranging from the Middle Ages into Finnish in a comprehensive anthology entitled Tuhat Laulujen Vuotta in 1957. She participated in the Art Competitions of the 1948 Summer Olympics in London, and won the gold medal in the Lyric Works, Literature category for "Laurel of Hellas".

## Biography

Tynni was born in Ingria into an Ingrian Finnish family. She married fellow poet Martti Haavio, her second husband, in 1960. After he died in 1973, Tynni and Katariina Eskola compiled his notes and correspondence, which were later released as a series of books.
She is buried in the Hietaniemi Cemetery in Helsinki.

## Works

* Kynttiläsydän, 1938
* Vesilintu, 1940
* Lähde ja matkamies, 1943
* Lehtimaja, 1946
* Soiva metsä, 1947
* Ylitse vuorten lasisten, 1949
* Tuntematon puu, 1952
* Kerttu ja Perttu ja muut talon lapset, 1953
* Kissa liukkaalla jäällä ja muita satuja, 1954
* Torni virrassa, 1954
* Vieraana vihreällä saarella, 1954
* Heikin salaisuudet, 1956
* Tuhat laulujen vuotta, 1957
* Yhdeksän kaupunkia, 1958
* Maailmanteatteri, 1961
* Muuttohaukat, 1965
* Balladeja ja romansseja, 1967
* Lasten paratiisi, 1968
* Pidä rastaan laulusta kiinni, 1969
* Tarinain lähde, 1974
* Olen vielä kaukana, 1978
* Vuodenajat, 1987
* Inkeri, Inkerini, 1990
* Rautamarskin aika, 1991 (näytelmä)
# 2011 Copa Libertadores First Stage

The First Stage of the 2011 Copa Santander Libertadores de América football tournament ran from January 25 to February 3, 2011 (first legs: January 25–27; second legs: February 1–3).

## Format

The twelve teams were drawn into six ties on November 25, 2010, in Asunción.
Teams played in two-legged ties on a home-away basis. Each team earned 3 points for a win, 1 point for a draw, and 0 points for a loss. The following criteria were used for breaking ties on points:
* Goal difference
* Away goals
* Penalty shootout (no extra time is played)
The six winners advanced to the second stage to join the 26 automatic qualifiers.

## Matches

Team 1 played the second leg at home.
| Teams | Teams | Teams | Scores | Scores | Tie-breakers | Tie-breakers | Tie-breakers |
| Team 1 | Points | Team 2 | 1st leg | 2nd leg | GD | AG | Pen. |
| Deportes Tolima | 4:1 | Corinthians | 0–0 | 2–0 | — | — | — |
| Chiapas | 6:0 | Alianza Lima | 2–0 | 2–0 | — | — | — |
| Deportivo Petare | 1:4 | Cerro Porteño | 0–1 | 1–1 | — | — | — |
| Unión Española | 4:1 | Bolívar | 1–0 | 0–0 | — | — | — |
| Deportivo Quito | 3:3 | Independiente | 0–2 | 1–0 | −1:+1 | — | — |
| Grêmio | 4:1 | Liverpool | 2–2 | 3–1 | — | — | — |

### Match G1

Deportes Tolima won on points 4–1.

### Match G2

Jaguares won on points 6–0.

### Match G3

Cerro Porteño won on points 4–1.

### Match G4

Unión Española won on points 4–1.

### Match G5

Tied on points 3–3, Independiente won on goal difference.

### Match G6

Grêmio won on points 4–1.
# Boholano dialect

Boholano (Cebuano: Binol-anon) is a variant of the Cebuano language spoken in the island province of Bohol in the Visayas and a major portion of Southern Leyte, as well as parts of Mindanao, particularly in Northern Mindanao and Caraga. It is sometimes erroneously described as a separate language even though Binol-anon originated as a dialect continuum of the Cebuano language.
Boholano, especially as spoken in central Bohol, can be distinguished from other Cebuano variants by a few phonetic changes:
* The semivowel y is pronounced [dʒ] as is the ll sound (similar to Spanish Yeísmo): iya is pronounced [iˈdʒa];
* Ako is pronounced as [aˈho];
* Intervocalic l is occasionally pronounced as [w] when following u or o: kulang is pronounced as [ˈkuwaŋ] (the same as Cebu City dialect).

## History

The Bohol dialect developed in the region after the Cebuano language arrived there from Cebu. The Cebuano language, descended from Proto-Austronesian (ca. 6000 years ago), originated in the Sugbo heartland and then "has spread from its base in Cebu" to Bohol, thus beginning the Bohol Cebuano dialect.
# FC Vushtrria

FC Vushtrria is a football club based in Vushtrri, Kosovo. The club was founded in 1922, and currently play their home games at the 7,000 seat capacity Ferki Aliu Stadium in the city of Vushtrri. Notable players to have played for the club include former Albania internationals Armend Dallku, Ahmed Januzi and Kosovo international Milot Rashica.

## History

FC Vushtrria was founded in 1922 and is the oldest football club in Kosovo. It has been competing domestically in Kosovo ever since. Throughout the years after World War II, Vushtrri became well known for the production of youth players within the club. Many of these players were transferred to other Kosovar clubs such as Prishtina and Trepça due to them playing in former Yugoslav First League.
In 2012 the club was purchased by local steel galvanising plant, Llamkos GalvaSteel. When the club was taken over by Llamkos GalvaSteel and the Core Group, there were immediate investments made which resulted in the club winning their 2013–14 league title, which was the first in its history. Llamkos GalvaSteel then distanced itself from the club as did the club's owner Jeton Sadiku, leaving the financing and management in the hands of the Vushtrri municipality.

## Players
### Current squad

    As of 2 December 2019
Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.
| No. | Pos. | Nation | Player |
| — | GK | USA | Austin Rogers |
| — | GK | KOS | Petrit Tahiri |
| — | GK | KOS | Albin Kurti |
| — | DF | KOS | Etrit Halimi |
| — | DF | ALB | Nertil Hoxhaj |
| — | DF | KOS | Ilir Izmaku |
| — | DF | ALB | Klevis Lushaku |
| — | MF | KOS | Dren Ahmeti |
| — | MF | KOS | Besfort Dervishaj |
| — | MF | KOS | Djellon Dragusha |
| No. | Pos. | Nation | Player |
| — | MF | ALB | Eri Lamçja |
| — | MF | KOS | Daut Maxhuni |
| — | MF | ALB | Ledjon Muçaj |
| — | MF | KOS | Bashkim Shala |
| — | MF | BRA | Ygor Vinicius |
| — | FW | BRA | Ian Augusto |
| — | FW | BRA | Matheus de Paula |
| — | FW | ALB | Jasmin Raboshta |
| — | | KOS | Valmir Azemi |
| — | | KOS | Drilon Fazliu |

## Historical list of coaches

* Ajet Shosholli (Feb 1973 - 1975)
* Ismet Munishi (Mar 2013 - Oct 2014)
* Bekim Shotani (Jul 2015 - 7 Dec 2015)
* Isa Sadriu (7 Dec 2015 - 12 Jan 2016)
* Rizvan Jetullahu (12 Jan 2016 - Apr 2016)
* Bekim Shotani (13 Apr 2016 - May 2016)
* Isa Sadriu (28 Jun 2017 - 2 Jun 2018)
* Samuel Nikaj (14 Jun 2018 - 23 Jun 2019)
* Bekim Shotani (30 Jun 2019 - Sep 2019)
* Antonio Toma (8 Sep 2019 - 22 Oct 2019)
* Fitim Llapashtica (22 Oct 2019 - )
# Knut Hovden

Knut Hovden (January 3, 1880 – March 3, 1961) was a Norwegian canner, innovator, and businessman.
A graduate from the Norwegian school of fisheries, Hovden started his career working for the pioneer canner Frank E. Booth in Monterey, California in 1905. In 1916, he started his own cannery, Hovden Canning Co (later known as K.Hovden Company), which became the most successful cannery in Monterey in the heyday of the sardine industry. Hovden also ran other canneries along the West Coast and was widely recognised as the "King of Cannery Row".
Hovden modernized California's sardine industry. His innovation pervaded every stage of the canning process, from live fish to tin of sardines. Hovden developed the first mechanical dryer on the West Coast, eliminating the need to air-dry sardines, and the mechanical cooker, which used a chain-driven conveyor to move fish through vats of frying oil. In 1910, he introduced two soldering machines to seal the lids on the cans. By 1913, he and his brother, Ole Hovden, also began experimenting with a sardine cutting machine, which they perfected in 1918. Amongst Hovden's most influential innovation was also the fish hopper, a seabed connected to the canneries by underwater steel pipes, which literally sucked the sardines into the cannery for processing and storage. The innovation enabled the fishermen to unload the fish off shore.
Monterey Bay Aquarium is now on the site of Hovden's cannery. As a board member of the Pacific Grove Museum, Hovden was one of the first to champion the idea of an aquarium on the Monterey Peninsula already in the 1920s.
# Jirón Huancavelica

Jirón Huancavelica is a major street in the Damero de Pizarro, located in the historic centre of Lima, Peru. The street starts at its intersection with the Jirón de la Unión and continues until it reaches Jirón Ramón Cárcano.

## History

The road that today constitutes the street was laid by Francisco Pizarro when he founded the city of Lima on 18 January 1535. Since the end of the 16th century, a Corral de comedias existed on the street. In 1615, the first venue was built, which was destroyed by an earthquake in 1746. Since then, the venue has undergone several renovations and is now known as the Segura Theatre.
According to oral tradition, in 1651 an Angolan slave painted an image of the crucified Jesus Christ in a brotherhood of his caste in the Pachacamilla neighbourhood, where this street extends. An earthquake that occurred shortly after ruined the house, leaving only the wall that had the figure on it unscathed. In 1660, resident Andrés de León decided to build a small chapel for the worship of said image. However, as the ecclesiastical chapter of Lima did not consider the site decent, it ordered the destruction of the chapel and image. Given this, the site was acquired by the Biscayan captain Sebastián de Antuñano y Rivas who erected a temple for the veneration of the Holy Christ of Miracles as he began to be called. In 1730 the first church of the Sanctuary and Monastery of Las Nazarenas was built and in 1746 it was rebuilt because it was destroyed during an earthquake. The church is now the location of the cult of the Lord of Miracles.
In 1821, José de San Martín proclaimed the independence of Peru in the Plazoleta de la Merced, located in the first block of this road.
In 1862, when the new urban nomenclature was adopted, the road was renamed Jirón Huancavelica after the Department of Huancavelica. Prior to this renaming, each block (cuadra) had a unique name:
* Block 1: Lezcano, after Pedro de Lezcano Centeno y Valdez, who lived there.
* Block 2: Siete de Septiembre, changed from its original name of Coliseo to commemorate the arrival of San Martín to Paracas Bay, later known as the Plazuela del Teatro after the Segura Theatre.
* Block 3: Ortiz, after an unidentified neighbour of the same name.
* Block 4: Nazarenas, after the sanctuary of the same name.
* Block 5: Plazuela de Nazarenas, for the same reason.
* Block 6: Caballos, after a horse rental service there.
* Block 7: Torrecilla, after a structure of the same name in the property of Conquistador Jerónimo de Aliaga.
At the end of the 19th century, the road housed the home of Miguel Grau, who died during the War of the Pacific.
The Edificio Santo Toribio was built in the street's intersection with the Jirón Rufino Torrico in 1923 by Fred T. Ley & Cía, an American company. The three-storey, 925.30 m$^2$ work is part of the set of real estate projects undertaken by the Archbishop of Lima, Emilio Lissón, in the 1920s in order to strengthen the economic activities of the archdiocese.
# Pjetër Gjoka

Pjetër Gjoka (3 August 1912 – 12 May 1982) was an Albanian film and theatre actor.
He started his theatre activity with the amateur groups in Shkodër in 1929. In 1947 he started to work as a full-time actor in the National Theatre of Albania after his debut in the Army Theatre. His first role was in Molière's Tartuffe. He acted in around 90 roles during his career and he was active for around 52 years, acting even when he was almost completely blind. Some of his most acclaimed roles were those of Kharitonov, Shpend Gjeta, The Old Man (Plaku), MacDonald, Miller, Zabeliku, Klaudi, King Lear, Gjini and Ali Pasha of Gucia.
In 1961 he was one of the first four actors who was given the title of People's Artist of Albania. He also acted some artistic movies, creating very strong characters. His last role in the National Theatre of Albania was in the drama, Time before the Trial ("Epoka para gjyqit").
Along with his work as a stage actor he was also a movie actor, a director and a translator.

## Role in movies

* 1953: The Great Warrior Skanderbeg
* 1957: Femijet e saj
* 1958: Tana
* 1959: Furtuna
* 1969: Njesit gueril
* 1970: Gjurma
* 1975: Gjenerali i ushtrisë së vdekur
* 1978: I treti
* 1978: Yje mbi Drin
* 1981: Në prag të lirisë
# Harkaleh (disambiguation)

Harkaleh is a village in Khuzestan Province, Iran.
Harkaleh (Persian: هاركله) may also refer to:
* Harkaleh-ye Mohammad Jafar
* Harkaleh-ye Mohammadabad
* Harkaleh-ye Monari
# Skerik's Syncopated Taint Septet

Skerik's Syncopated Taint Septet (also known as SST7) is a jazz ensemble formed in Seattle, Washington, in 2002 and led by saxophonist Eric "Skerik" Walton.

## Music

Although uniquely merging jazz and funk, the music of Skerik's Syncopated Taint Septet can also include "New Orleans flavors", solid grooves, swing and hip hop, combined into something both appealing and undefinable. Their music has been self-described by Skerik as "punk-jazz. Maybe a punk-jazz version of the Thelonious Monk Octet."
A theme in the music is a recognition that traditional jazz having reached a zenith in the early 1960s cannot be contained in reverence. The Syncopated Taint Septet is a synthesis of traditional music with current and experimental music forms. The project displays a band member equality with "leads being shared by everyone."

## History

Their first album, Skerik's Syncopated Taint Septet, was recorded live at the Owl and Thistle in Seattle and was released in 2003. It was reviewed as occasionally loud, yet also having a "spirited [and] immediate musicianship." Although popularly associated with jam band music, an improvisational distinction can be made regarding the large musical vocabulary displayed by the band in the recording.
The second album, Husky, was released in 2006. It was recorded in the studio by S. Husky Höskulds all in one day and often in one take. The album was noted in reviews for its strengths in "ensemble writing and musical structure." The five-horn arrangements are written mostly by Hans Teuber and Steve Moore. On the album there are suggestions of Thelonious Monk in its solos and Ornette Coleman in its melodies, yet there is also a hip-hop rhythmic sensibility. Husky was reviewed as the best jazz album of 2006 by All About Jazz.

## Members

Skerik – tenor and baritone saxophone Dave Carter – trumpet Hans Teuber – alto saxophone and flute Steve Moore – trombone and Wurlitzer electric piano Craig Flory – baritone saxophone and clarinet Joe Doria – Hammond Organ John Wicks – drums

## Discography

* Skerik's Syncopated Taint Septet [live] (2003, Ropeadope)
* Husky (2006, Hyena)
* Live at The Triple Door (2010, Royal Potato Family)
# William Boys (MP)

William Boys (March 1541–1596) was an English politician.
He was a Member (MP) of the Parliament of England for Queenborough in 1589.
# Jirón Ica

Jirón Ica is a major street in the Damero de Pizarro, located in the historic centre of Lima, Peru. The street starts at its intersection with the Jirón de la Unión and continues until it reaches the Jirón Sancho Rivera.

## History

The road that today constitutes the street was laid by Francisco Pizarro when he founded the city of Lima on January 18, 1535. In 1862, when a new urban nomenclature was adopted, the road was named jirón Ica, after the department of Ica. Prior to this renaming, each block (cuadra) had a unique name:
* Block 1: Plateros de San Agustín, after the large number of silverware shops there.
* Block 2: San Agustín/Comedia Vieja, after the church of the same name and a Corral de comedias that existed in front of it, respectively.
* Block 3: Concha, after the family of the same name. The Teatro Municipal de Lima is located here.
* Block 4: La Riva, after Vicente de la Riva y San Cristóbal, who lived there. The Casa Fernandini is located here.
* Block 5: San Sebastián, after the church of the same name.
* Block 6: Orejuelas, after the family of the same name.
* Block 7: Chávez (de San Sebastián), for reasons unknown.
* Block 8: Medalla, for reasons unknown.
* Block 9: Molino (de Monserrate), after a windmill near the convent of Monserrate street.
The former Broggi brothers' confectionery was located on the street. Originally owned by the Charity of Lima, it belonged to the Swiss-Italian Broggi brothers, of which Pedro had initially founded it in 1858, but it was only in the 1870s that it became the meeting place for a number of artists, intellectuals and other important people from the city. The Sociedad de Beneficencia Helvetia (today the Club Suizo) and the Rotary Club de Lima's first meetings took place in the building. Regulars at the place included painter Felipe Sassone, writer Enrique A. Carrillo [es] and painter Luis Astete y Concha. Painter Pancho Fierro had a workshop inside the building, where journalist Ismael Portal [es] met him in 1879.
Also located in the street is the Edificio Zevallos, the work of Augusto Benavides Diez Canseco after being commissioned by the property's owner Elena Zevallos Dávila in 1926. It had originally been the property of the Monastery of the Holy Trinity since colonial times.
The Casona Pancho Fierro, named after the painter, is located on the second block of the street. In 2018, a fire broke out and destroyed 80% of the property. Villa Chicken, the restaurant chain that operated in the building, was able to fund its reconstruction.