# List of U.S. Routes in Missouri
## List

| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| US 24 | 215.560 | 346.910 | US 24 at Kansas City | US 24 at West Quincy | 01926-01-011926 | current | |
| US 36 | 192.660 | 310.056 | US 36 at St. Joseph | I-72/US 36/IL 110 (CKC) at Hannibal | 01926-11-111926 | current | |
| US 40 | 255.838 | 411.731 | US 40 at Kansas City | I-55/I-64/US 40 at St. Louis | 01926-11-111926 | current | |
| US 50 | 261.946 | 421.561 | US 50 at Kansas City | I-255/US 50 at St. Louis | 01926-11-111926 | current | |
| US 54 | 271.494 | 436.927 | US 54 west of Nevada | US 54 at Louisiana | 01927-01-011927 | current | |
| US 55 | 3.096 | 4.983 | — | — | — | — | Proposed number for what would become US 56. |
| US 56 | 3.096 | 4.983 | US 56 at Kansas City | US 71 in Kansas City | 01956-06-271956 | current | |
| US 59 | 106.256 | 171.002 | US 59 east of Atchison, KS | US 59 north of Rock Port | 01934-01-011934 | current | |
| US 60 | 320 | 510 | — | — | 01926-01-011926 | — | Proposed number for what would become US 66. |
| US 60 | 341.232 | 549.160 | US 60 at Seneca | US 60 east of Charleston | 01926-11-111926 | current | |
| US 61 | 392.847 | 632.226 | US 61 south of Steele | US 61 west of Keokuk, IA | 01926-11-111926 | current | |
| US 62 | 341.232 | 549.160 | — | — | 01926-01-011926 | — | Proposed number for what would become US 60. |
| US 62 | 86.705 | 139.538 | US 62 west of Campbell | US 62 east of Charleston | 01930-01-011930 | current | |
| US 63 | 337.750 | 543.556 | US 63 at Thayer | US 63 north of Lancaster | 01926-01-011926 | current | |
| US 65 | 313.114 | 503.908 | US 65 south of Branson | US 65 north of Princeton | 01926-11-111926 | current | |
| US 66 | 320 | 510 | US 66 west of Joplin | US 66 at St. Louis | 01926-11-111926 | 01985-06-261985 | |
| US 67 | 197.582 | 317.977 | US 67 south of Poplar Bluff | US 67 east of West Alton | 01926-11-111926 | current | |
| US 69 | 121.704 | 195.864 | US 69 at Northmoor | US 69 north of Bethany | 01926-11-111926 | current | |
| US 71 | 316.722 | 509.715 | US 71 south of Pineville | US 71 north of Maryville | 01926-01-011926 | current | |
| US 73 | 1.65 | 2.66 | — | — | 01926-01-011926 | 02007-01-012007 | Decommissioned in Missouri. |
| US 78 | — | — | — | — | — | — | Former proposal highway in Missouri. |
| US 80 | — | — | — | — | — | — | Former proposal highway in Missouri. |
| US 136 | 257.457 | 414.337 | US 136 west of Rock Port | US 136 west of Keokuk, IA | 01951-01-011951 | current | |
| US 159 | 17.648 | 28.402 | US 159 east of Rulo, NE | US 59 north of St. Joseph | 01935-01-011935 | current | |
| US 160 | 323.417 | 520.489 | US 160 west of Lamar | US 67/Route 158 near Poplar Bluff | 01930-01-011930 | current | |
| US 166 | 0.936 | 1.506 | US 166 west of Joplin | I-44 west of Joplin | 01926-11-111926 | current | |
| US 169 | 126.908 | 204.239 | US 169 at Kansas City | US 169 north of Grant City | 01930-01-011930 | current | |
| US 271 | — | — | — | — | 01960-01-011960 | — | Former proposal highway in Missouri; now US 59. |
| US 275 | 15.106 | 24.311 | US 136 in Rock Port | US 275 south of Hamburg, IA | 01932-01-011932 | current | |
| US 400 | 0.936 | 1.506 | US 400 west of Joplin | I-44 west of Joplin | 01994-01-011994 | current | |
| US 412 | 50.767 | 81.702 | US 412 south of Senath | I-155/US 412 east of Caruthersville | 01988-01-011988 | current | |
| US 460 | 1 | 1.6 | St. Louis | US 460 at St. Louis | 01933-01-011933 | 01976-01-011976 | |
| Former ||||||||

## Special routes

| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Serves | Formed | Removed | Notes |
| US 24 Opt. | — | — | — | — | Kansas City to Independence | — | — | |
| US 24 Alt. | 1.97 | 3.17 | — | — | Lexington | — | — | |
| US 24 Bus. | — | — | — | — | Napoleon to Lexington | — | — | |
| US 24 Bus. | 2.48 | 3.99 | — | — | Carrollton | — | — | |
| US 24 City | — | — | — | — | Kirksville | — | — | |
| US 24 Bus. | 3.50 | 5.63 | — | — | Paris | — | — | |
| US 36 Bus. | — | — | — | — | St. Joseph | — | — | |
| US 36 Bus. | 1.50 | 2.41 | — | — | Cameron | — | — | |
| US 36 Bus. | 2.82 | 4.54 | — | — | Hamilton | — | — | |
| US 36 Bus. | — | — | — | — | Mooresville | — | — | |
| US 36 Bus. | 1.05 | 1.69 | — | — | Chillicothe | — | — | |
| US 36 Bus. | 2.65 | 4.26 | — | — | Brookfield | — | — | |
| US 36 Bus. | 3.03 | 4.88 | — | — | Macon | — | — | |
| US 36 Spur | 1 | 1.6 | — | — | Macon | — | — | |
| US 36 Bus. | 1.28 | 2.06 | — | — | Clarence | — | — | |
| US 36 Bus. | 1.77 | 2.85 | — | — | Shelbina | — | — | |
| US 36 Bus. | 2.47 | 3.98 | — | — | Monroe City | — | — | |
| US 36 Bus. | 3.76 | 6.05 | — | — | Hannibal | — | — | |
| US 36 Alt. | 3.65 | 5.87 | US 36 in Hannibal | US 36/Route 79 in Hannibal | Hannibal | — | — | Replaced by US 61 and Route 79 |
| US 36 City | 3.76 | 6.05 | — | — | Hannibal | — | — | |
| US 40 Opt. | — | — | — | — | Kansas City | — | — | |
| US 40 City | — | — | — | — | Kansas City | — | — | |
| US 40 Alt. | — | — | — | — | Kansas City to Independence | — | — | |
| US 40 Opt. | — | — | — | — | Kansas City to Leeds | — | — | |
| US 40 Opt. | — | — | — | — | Independence to Kansas City | — | — | |
| US 40 Bus. | — | — | — | — | Columbia | — | — | |
| US 40 Byp. | — | — | — | — | Wentzville, Missouri to Troy, Illinois | — | — | |
| US 40 City | — | — | — | — | Pattonville to St. Louis | — | — | |
| US 40 Truck | — | — | — | — | Frontenac, Missouri to East St. Louis, Illinois | — | — | |
| US 40 Alt. | — | — | — | — | Bridgeton to St. Louis | — | — | |
| US 40 Bus. | — | — | — | — | St. Louis | — | — | |
| US 40 Spur | — | — | — | — | St. Louis | — | — | |
| US 50 Opt. | — | — | — | — | Olathe, Kansas to Lone Jack, Missouri | — | — | |
| US 50 Bus. | 2.53 | 4.07 | — | — | Warrensburg | — | — | |
| US 50 Bus. | 1.11 | 1.79 | — | — | Knob Noster | — | — | |
| US 50 Temp. | — | — | — | — | Sedalia | — | 01931-01-011931 | Served Sedalia |
| US 50 Spur | 1.21 | 1.95 | — | — | Smithton | — | — | |
| US 50 Bus. | 5.26 | 8.47 | — | — | California | — | — | |
| US 50 Bus. | 4.08 | 6.57 | — | — | St. Martins to Apache Flats | — | — | |
| US 50 Bus. | — | — | — | — | Jefferson City | — | — | |
| US 50 Bus. | 2.97 | 4.78 | — | — | Jefferson City | — | — | |
| US 50 Bus. | — | — | — | — | Brentwood to St. Louis | — | — | |
| City US 50 | — | — | — | — | Brentwood to St. Louis | — | — | |
| US 50 Byp. | — | — | — | — | Mehlville, Missouri to Fairview Heights, Illinois | — | — | |
| US 50 Truck | — | — | — | — | St. Louis | — | — | |
| US 54 Bus. | 5.15 | 8.29 | — | — | Lake Ozark | — | — | |
| US 54 Bus. | 5.57 | 8.96 | — | — | Eldon | — | — | |
| US 54 Alt. | — | — | — | — | Jefferson City | — | — | |
| US 54 Bus. | 5.71 | 9.19 | — | — | Fulton | — | — | |
| US 54 Bus. | 6.11 | 9.83 | — | — | Mexico | — | — | |
| US 54 Bus. | 2.967 | 4.775 | — | — | Bowling Green | — | — | |
| US 54 Bus. | 3.375 | 5.432 | — | — | Louisiana | — | — | |
| US 59 Bus. | — | — | — | — | Industrial City to St. Joseph | — | — | |
| City US 59 | — | — | — | — | Industrial City to St. Joseph | — | — | |
| US 59 Spur | — | — | — | — | St. Joseph | — | — | Now Missouri Route 759 |
| US 60 Bus. | 1.36 | 2.19 | — | — | West Seneca, Oklahoma to Seneca, Missouri | — | — | |
| US 60 Bus. | 7.14 | 11.49 | — | — | Neosho | — | — | |
| US 60 Bus. | 5.91 | 9.51 | — | — | Monett | — | — | |
| US 60 Bus. | 8.01 | 12.89 | — | — | Verona to Aurora | — | — | |
| US 60 Bus. | — | — | — | — | Springfield | — | — | |
| US 60 City | — | — | — | — | Springfield | — | — | |
| US 60 Bus. | 3.38 | 5.44 | — | — | Rogersville | — | — | |
| US 60 Bus. | 2.22 | 3.57 | — | — | Mansfield | — | — | |
| US 60 Bus. | 6.51 | 10.48 | — | — | Mountain Grove | — | — | |
| US 60 Bus. | 4.32 | 6.95 | — | — | Cabool | — | — | |
| US 60 Bus. | 5.86 | 9.43 | — | — | Willow Springs | — | — | |
| US 60 Bus. | 2.08 | 3.35 | — | — | Van Buren | — | — | |
| US 60 Bus. | 7.79 | 12.54 | — | — | Poplar Bluff | — | — | |
| US 60 Bus. | 4.28 | 6.89 | — | — | Dexter | — | — | |
| US 60 Bus. | 17.2 | 27.7 | — | — | Sikeston to Charleston | — | — | |
| US 61 Bus. | — | — | — | — | Holland to Steele | — | — | |
| US 61 Spur | 0.495 | 0.797 | — | — | New Madrid | — | — | |
| US 61 Bus. | 2.57 | 4.14 | — | — | Sikeston | — | — | |
| US 61 Bus. | — | — | — | — | Cape Girardeau | — | — | |
| City US 61 | — | — | — | — | Cape Girardeau | — | — | |
| US 61 Alt. | — | — | — | — | St. Louis | — | — | |
| US 61 Bus. | 4.46 | 7.18 | — | — | Bowling Green | — | — | |
| US 61 Spur | 0.460 | 0.740 | — | — | Bowling Green | — | — | |
| US 61 Bus. | 1.92 | 3.09 | — | — | New London | — | — | |
| US 61 Bus. | 6.34 | 10.20 | — | — | Hannibal | — | — | |
| US 61 City | 6.34 | 10.20 | — | — | Hannibal | — | — | |
| US 61 Bus. | 3.43 | 5.52 | — | — | Palmyra | — | — | |
| US 61 Bus. | 4.68 | 7.53 | — | — | La Grange | — | — | |
| US 61 Bus. | 4.94 | 7.95 | — | — | Canton | — | — | |
| City US 62 | — | — | — | — | Sikeston | — | — | |
| US 63 Bus. | 2.13 | 3.43 | — | — | Thayer | — | — | |
| US 63 Bus. | 4.01 | 6.45 | — | — | West Plains | — | — | |
| US 63 Bus. | 4.41 | 7.10 | — | — | Willow Springs | — | — | |
| US 63 Bus. | 4.32 | 6.95 | — | — | Cabool | — | — | |
| US 63 Bus. | — | — | — | — | Columbia | — | — | |
| US 63 Conn. | 1.251 | 2.013 | — | — | Columbia | — | — | |
| US 63 Spur | — | — | — | — | Columbia | — | — | |
| US 63 Bus. | 9.58 | 15.42 | — | — | Renick to Moberly | — | — | |
| US 63 Bus. | 7.13 | 11.47 | — | — | Kirksville | — | — | |
| City US 63 | — | — | — | — | Kirksville | — | — | |
| US 65 Spur | 2.03 | 3.27 | — | — | Tina | — | — | |
| US 65 Bus. | 4.51 | 7.26 | — | — | Point Lookout to Branson | — | — | |
| US 65 Bus. | 4.03 | 6.49 | — | — | Ozark | — | — | |
| US 65 Bus. | 9.20 | 14.81 | — | — | Springfield | — | — | |
| US 65 Byp. | — | — | — | — | Springfield | — | — | |
| US 65 Spur | 1.75 | 2.82 | — | — | Warsaw | — | — | |
| US 65 Bus. | 5.02 | 8.08 | — | — | Marshall | — | — | |
| US 65 Bus. | 2.47 | 3.98 | — | — | Carrollton | — | — | |
| US 65 Bus. | 2.93 | 4.72 | — | — | Trenton | — | — | |
| City US 65 | — | — | — | — | Trenton | — | — | |
| US 66 Alt. | — | — | — | — | Joplin | — | — | |
| US 66 Bus. | — | — | — | — | Joplin | — | — | |
| US 66 Byp. | — | — | — | — | Joplin | — | — | |
| US 66 Alt. | — | — | — | — | Joplin to Webb City | — | — | |
| US 66 Bus. | — | — | — | — | Webb City to Carterville | — | — | |
| US 66 Alt. | — | — | — | — | Carthage to Kendricktown | — | — | |
| US 66 Bus. | — | — | — | — | Carthage | — | — | |
| US 66 Bus. Alt. | — | — | — | — | Springfield | — | — | |
| US 66 Bus. | — | — | — | — | Springfield | — | — | |
| US 66 Byp. | — | — | — | — | Springfield | — | — | |
| City US 66 | — | — | — | — | Springfield | — | — | |
| US 66 Bus. | — | — | — | — | Lebanon | — | — | |
| US 66 Bus. | — | — | — | — | Waynesville | — | — | |
| US 66 Spur | — | — | — | — | Fort Leonard Wood | — | — | |
| US 66 Bus. | — | — | — | — | Rolla | — | — | |
| City US 66 | — | — | — | — | Rolla | — | — | |
| US 66 Bus. | — | — | — | — | Pacific | — | — | |
| US 66 Bus. | — | — | — | — | St. Louis to Sunset Hills | — | — | |
| US 66 Byp. | — | — | — | — | St. Louis to Sunset Hills | — | — | |
| US 66 Opt. | — | — | — | — | St. Louis, Missouri to Venice, Illinois | — | — | |
| City US 66 | — | — | — | — | St. Louis, Missouri to Mitchell, Illinois | — | — | |
| City US 66 | — | — | — | — | Kirkwood to Bellefontaine Neighbors | — | — | |
| US 67 Bus. | 7.34 | 11.81 | — | — | Poplar Bluff | — | — | |
| US 67 Bus. | 2.33 | 3.75 | — | — | Greenville | — | — | |
| US 67 Bus. | 7.97 | 12.83 | — | — | Fredericktown to Cherokee Pass | — | — | |
| US 67 Bus. | 5.27 | 8.48 | — | — | Leadington to Park Hills | — | — | |
| US 67 Alt. | — | — | — | — | Mehlville, Missouri to Alton, Illinois | — | — | |
| US 67 Byp. | — | — | — | — | Mehlville, Missouri to Alton, Illinois | — | — | |
| US 69 Alt. | — | — | — | — | Kansas City, Missouri to Olathe, Kansas | — | — | |
| US 69 Bus. | — | — | — | — | Excelsior Springs | — | — | |
| US 69 Spur | 0.84 | 1.35 | — | — | Bethany | — | — | |
| Temp. US 71 | — | — | — | — | Bentonville, Arkansas to Lanagan, Missouri | — | — | |
| US 71 Byp. | 18.9 | 30.4 | — | — | Douglas County, Missouri to Bella Vista, Arkansas | — | — | |
| US 71 Bus. | 12.7 | 20.4 | — | — | Pineville to Anderson | — | — | Known as an alternate alignment to US 71 in 2019 |
| US 71 Bus. | — | — | — | — | Neosho | — | — | |
| US 71 Alt. | — | — | — | — | Neosho to Carthage | — | — | |
| US 71 Opt. | — | — | — | — | Neosho to Carthage | — | — | |
| US 71B | — | — | — | — | Saginaw to Webb City via Joplin | — | — | |
| US 71 Spur | 1.15 | 1.85 | — | — | Milo | — | — | |
| US 71 Bus. | — | — | — | — | Nevada | — | — | |
| US 71 Bus. | — | — | — | — | Butler to Passaic | — | — | |
| US 71 Bus. | — | — | — | — | Kansas City | — | — | |
| City US 71 | — | — | — | — | Kansas City | — | — | |
| US 71 Byp. | — | — | — | — | Harrisonville to Ferrelview via Kansas City | — | — | |
| US 71 Byp. | — | — | — | — | Tracy | — | — | |
| US 71 Byp. | — | — | — | — | Platte City | — | — | |
| City US 71 | — | — | — | — | Faucett to St. Joseph | — | — | |
| US 71 Bus. | 8.94 | 14.39 | — | — | St. Joseph to Savannah | — | — | |
| US 71 Spur | — | — | — | — | St. Joseph | — | — | |
| US 71 Bus. | 5.12 | 8.24 | — | — | Maryville | — | — | |
| US 136 Bus. | 1.73 | 2.78 | — | — | Albany | — | — | |
| US 136 Bus. | 0.97 | 1.56 | — | — | Memphis | — | — | |
| US 136 Spur | 0.71 | 1.14 | — | — | Arbela | — | — | |
| US 136 Bus. | 3.59 | 5.78 | — | — | Kahoka | — | — | |
| US 136 Spur | 1.10 | 1.77 | — | — | Wayland | — | — | |
| US 160 Bus. | 1.90 | 3.06 | — | — | Willard | — | — | |
| City US 160 | — | — | — | — | Springfield | — | — | |
| US 166 Bus. | — | — | — | — | Joplin | — | — | |
| US 166 Bus. | — | — | — | — | Springfield | — | — | |
| City US 166 | — | — | — | — | Springfield | — | — | |
| US 166 Truck | — | — | — | — | Springfield | — | — | |
| US 169 Alt. | — | — | — | — | Kansas City, Kansas to Northmoor | — | — | |
| US 169 Spur | 0.48 | 0.77 | — | — | Smithville | — | — | |
| US 412 Alt. | 1.87 | 3.01 | — | — | Kennett | — | — | A temporary alternate route assigned to parts of Highways W and VV. |
| US 460 Spur | 45.33 | 72.95 | — | — | St. Louis | — | — | |
| Former |||||||||