OpenLLM-France/wikimedia huggingface dataset:
# Revital Sharon

Revital Sharon (Hebrew: רויטל שרון; born December 2, 1970) is an Israeli former Olympic artistic gymnast. At the age of 11, in 1982 Sharon won a gold medal at the International Workers’ Games in Italy. In 1988, Sharon was Israel's National Women's all-around champion, and was named Israel's 1988 Sportswoman of the Year.
She was born in Kiryat Bialik, Israel, and is Jewish.

## Gymnastics career

Sharon competed for Hapoel Kiryat Bialik. She was coached by Israeli national team coach Zahava Zissman.
At the age of 11, in 1982 Sharon won a gold medal at the International Workers’ Games in Italy. At the age of 14, she finished 120th at the 1985 World Artistic Gymnastics Championships, in Montreal, Canada.
In 1987, Sharon competed at the 1987 World Artistic Gymnastics Championships in Rotterdam in the Netherlands and finished in 92nd place out of 201 gymnasts in the all-around competition. Asked about boyfriends, she told Danny Ben-Tal of The Jerusalem Post: "They'll have to wait a year or two; the Olympics won't."
Sharon competed for Israel at the 1988 Summer Olympics in Seoul, South Korea, at the age of 17 in Gymnastics. In Women's Individual All-Around she came in 77th, in Women's Floor Exercise she came in 61st, in Women's Horse Vault she came in 48th, in Women's Uneven Bars she came in 81st, and in Women's Balance Beam she came in 78th. When she competed in the Olympics, she was 5-4.5 (164 cm) tall and weighed 108 lbs (49 kg).
That same year Sharon was Israel's National Women's all-around champion. She was named Israel's 1988 Sportswoman of the Year.
# Thulusdhoo (Kaafu Atoll)

Thulusdhoo (Dhivehi: ތުލުސްދޫ) is the capital of Kaafu Atoll, which is an administrative division of the Maldives.
The island is 26.81 km (17 mi; 14 nmi) northeast of the country's capital, Malé.

## Geography

The island is 26.81 km (17 mi; 14 nmi) northeast of the country's capital, Malé. Thulusdhoo is 1.580 km (0.982 mi) in length and just 0.680 km (0.423 mi) wide, with a total land area of 33 ha (82 acres).
# Midnight (1998 film)

Midnight (Portuguese: O Primeiro Dia) is a 1998 Brazilian-French drama film directed by Walter Salles and Daniela Thomas for the 2000, Seen By... series.

## Cast

* Fernanda Torres as Maria
* Luiz Carlos Vasconcelos as João
* Matheus Nachtergaele as Francisco
* Nelson Sargento as Vovô
* Tonico Pereira as Carcereiro
* Áulio Ribeiro
* Luciana Bezerra
* Antônio Gomes
* Nelson Dantas
* Carlos Vereza
* José Dumont

## Production

Its production was ordered by the Franco-German TV network Arte that asked ten filmmakers of different countries about the turn of the century for the 2000, Seen By... project. A co-production with France, it was produced in three weeks with a low budget.

## Reception

It won the 2000 Ariel Award for Best Ibero-American Film, and the 1st Grande Prêmio Cinema Brasil for Best Actor (Nachtergaele), Director and Screenplay.
# Stockdorf station

Stockdorf station (German: Bahnhof Stockdorf) is a railway station in the district of Stockdorf, within the municipality of Gauting, in Bavaria, Germany. It is located on the Munich–Garmisch-Partenkirchen railway of Deutsche Bahn.

## Services

As of the December 2021 timetable change, the following services stop at Stockdorf:
* Munich S-Bahn S6: service every twenty minutes between Tutzing and Grafing Bahnhof; some trains continue from Grafing Bahnhof to Ebersberg.
# Mazepa family

The Mazepa family (Ukrainian: Мазепа) was a noble Ruthenian/Ukrainian family. Their origin can be traced back to 1544, when the Ukrainian szlachtych Mykola Mazepa-Koledynski was given a khutor (farmstead) Kamyanets (which later grew to become the village of Mazepyntsi) by King Sigismund I for his duty.
Mykola Mazepa-Koledynski had two grandsons:
* Fedir Mykhaylovych Mazepa – a Cossack otaman. He fought against the Poles together with Hryhory Loboda, Severyn Nalyvaiko & Krzysztof Kosiński. Later he was caught and together with Severyn Nalyvaiko was executed in Warsaw.
* Stepan-Adam Mazepa. His spouse Maryna Mazepa (died 1707) of Mokiev descent became a nun and later hegumenia of the Frolov-Voznesenski Monastery [uk] in Kiev. They had a son, Ivan, and a daughter, who later married Andrew Voynorovskiy.

## Notable members

* Ivan Mazepa (1639–1709) – Hetman of Zaporizhian Host (1687–1709)
* Andriy Voynarovsky (1689-1740) - nephew and heir of Ivan Mazepa, member of the Zaporozhian Army
* Isaak Mazepa (1884–1952) – Prime minister of Ukraine
* Anna Politkovskaya (1958–2006)
* Mazepa family in Kostobobriv
* Isaak Mazepa
* Anna Politkovskaya, née Mazepa.
* Mykola Mazepa (Mykola Mazepa) Ukrainian Wikipedia
# Kostur Point

Kostur Point (Bulgarian: нос Костур, ‘Nos Kostur’ \'nos kos-'tur\) is the point on the east coast of Brabant Island in the Palmer Archipelago, Antarctica projecting 1.4 km southwards into Hill Bay.
The point is named after the settlement of Kostur in southeastern Bulgaria.

## Location

Kostur Point is located at 64°09′55″S 62°03′56″W﻿ / ﻿64.16528°S 62.06556°W﻿ / -64.16528; -62.06556 which is 4.2 km southwest of Spallanzani Point and 2.7 km north-northeast of Petroff Point. British mapping in 1980.

## Maps

* Antarctic Digital Database (ADD). Scale 1:250000 topographic map of Antarctica. Scientific Committee on Antarctic Research (SCAR). Since 1993, regularly upgraded and updated.
* British Antarctic Territory. Scale 1:200000 topographic map. DOS 610 Series, Sheet W 64 62. Directorate of Overseas Surveys, Tolworth, UK, 1980.
* Brabant Island to Argentine Islands. Scale 1:250000 topographic map. British Antarctic Survey, 2008.
# Serra da Estrela Subregion

Serra da Estrela (Portuguese pronunciation:) is a former NUTS3 statistical subregion of Portugal integrated in the NUTS2 Centro region that takes its name from the largest mountain range in Portugal - the Serra da Estrela. It was abolished at the January 2015 NUTS 3 revision.
Bordered to the north by Dão-Lafões, to the west by Beira Interior Norte, to south by Cova da Beira, and to the east by Pinhal Interior Norte the subregion contains the Serra da Estrela, the largest range and highest mountain in Portugal and much of the 1000 km$^2$ Natural Park of Serra da Estrela. The subregion itself is only 867.8 km$^2$.

## Municipalities

It consists of 3 municipalities (Portuguese: concelhos) from the Guarda District:
* Fornos de Algodres
* Gouveia
* Seia
# Ferzol

Ferzol (Arabic: فرزل), also spelled Forzol, Ferzul or Fourzol, is a village located in the Zahlé District of the Beqaa Governorate in Lebanon.
El Fourzol is situated south of Nabi Ayla, and west of Ablah.

## History

In 1838, Eli Smith noted Ferzol's population being Catholics.
# Labergement-Sainte-Marie station

Labergement-Sainte-Marie station (French: Gare de Labergement-Sainte-Marie) is a railway station in the commune of Labergement-Sainte-Marie, in the French department of Doubs, in the Bourgogne-Franche-Comté region. It is an intermediate stop on the Dijon–Vallorbe line of SNCF.

## Services

The following services stop at Labergement-Sainte-Marie:
* TER Bourgogne-Franche-Comté: regional service between Pontarlier and Vallorbe, in Switzerland.
# Augustfehn railway station

Augustfehn (German: Bahnhof Augustfehn) is a railway station located in Augustfehn, Germany. The station is located on the Oldenburg–Leer railway. The train services are operated by Deutsche Bahn.

## Train services

The following services currently call at the station:
* Intercity services IC 56 Norddeich - Emden - Leer - Bremen - Hannover - Braunschweig - Magdeburg - Leipzig / Berlin - Cottbus
* Regional services RE 1 Norddeich - Emden - Oldenburg - Bremen - Nienburg - Hanover
# Begum Dolly Azad

Kamar Jehan Sekandra Begum, better known as Begum Dolly Azad (Bengali: বেগম ডলি আজাদ, Urdu: بیگم ڈولی آزاد), was an East Pakistani politician.

## Early life and family

Begum was born into a Muslim family in Bogra District, Bengal Presidency, British Raj. She resided in 19 New Eskaton Road, Ramna Thana, Dacca after marrying Khwaja Mohammad Azad of the Dhaka Nawab family, where she inherited vast amounts of land. Mohammad Azad was an officer among the lieutenants of East Pakistan Army.

## Career

In 1949, Azad became a founding member of the All Pakistan Women's Association (which later became the Bangladesh Mahila Samiti). She played an active role during the Association's 5th Triennial Conference in Dacca, which was held in February 1968.
She became a member of the 4th National Assembly of Pakistan as a representative of East Pakistan in 1965. In 1966, she requested the government of Pakistan to increase the number of reserved seats for the women in the National Assembly. She visited China as part of a two-week Pakistani delegation, in which she sang a Chinese patriotic song called Unity is Strength.
With the aftermath of the Bangladesh Liberation War and subsequent Independence of Bangladesh, Azad abandoned her residence and migrated to West Pakistan. Her home was later gifted to the families of Serajuddin Hossain and Abul Kalam Azad who were said to have been killed by Al-Badr forces during the war. She later returned to the property, and a court case took place between Azad against the families residing there.
# Toshiki Yamamoto

Toshiki Yamamoto (山本俊樹; born (1991-09-08)8 September 1991) is a Japanese weightlifter, competing in the 85 kg category until 2018 and 96 kg starting in 2018 after the International Weightlifting Federation reorganized the categories.

## Career

He competed at the 2018 World Weightlifting Championships finishing ninth overall in the 89 kg division. At the 2019 World Weightlifting Championships he finished fifth overall in the same category.

## Major results

| Year | Venue | Weight | Snatch (kg) | Snatch (kg) | Snatch (kg) | Snatch (kg) | Clean & Jerk (kg) | Clean & Jerk (kg) | Clean & Jerk (kg) | Clean & Jerk (kg) | Total | Rank |
| Year | Venue | Weight | 1 | 2 | 3 | Rank | 1 | 2 | 3 | Rank | Total | Rank |
| Representing Japan |||||||||||||
| World Championships |||||||||||||
| 2013 | Wrocław, Poland | 77 kg | 140 | 140 | 140 | -- | 168 | 173 | 177 | 15 | -- | -- |
| 2017 | Anaheim, United States | 85 kg | 148 | 153 | 153 | 14 | 192 | 193 | 202 | 7 | 341 | 10 |
| 2018 | Ashgabat, Turkmenistan | 89 kg | 155 | 160 | 163 | 11 | 190 | 199 | 208 | 8 | 362 | 9 |
| 2019 | Pattaya, Thailand | 89 kg | 155 | 160 | 160 | 13 | 193 | 200 | 208 | | 368 | 5 |
| Asian Games |||||||||||||
| 2018 | Jakarta, Indonesia | 85 kg | 145 | 151 | 155 | 6 | 191 | 198 | 198 | 3 | 346 | 4 |
| Asian Championships |||||||||||||
| 2017 | Ashgabat, Turkmenistan | 85 kg | 145 | 152 | 152 | 7 | 185 | 192 | 199 | | 351 | |
| 2019 | Ningbo, China | 89 kg | 155 | 160 | 160 | 5 | 195 | 203 | 203 | | 358 | |
| 2020 | Tashkent, Uzbekistan | 96 kg | 160 | 165 | 170 | 5 | 201 | 205 | 217 | | 370 | 4 |
# Hetq

Hetq (Armenian: Հետք, lit. 'Trace') is an online newspaper published in Yerevan by the Investigative Journalists NGO. It first appeared in 2001 in the Armenian language, and since 2002 it has been publishing in English as well.
The Investigative Journalists of Armenia NGO is a non-government organization founded on 29 July 2000, with the primary goal of assisting the development of investigative journalism in Armenia and to strengthen and develop freedom of speech and democratic principles.

## History

Since 2001 the organization has produced investigative films and articles on environmental, social, educational, cultural, judicial, energy, the banking system, and other issues within the scope of different projects. These investigations have revealed various abuses by state and local government as well as the violation of human rights.
Since 2001, the organization has published the Hetq Online internet newspaper: The English version of Hetq Online has been published since September 2002, thus garnering authority and credibility amongst foreign readers for the organization.
The investigative articles of Hetq Online are republished by leading Armenian daily newspapers. Hetq Online is the first publication in Armenia to adopt a code of ethics and every journalist working with the online newspaper is obliged to follow the principles of the code.

## Membership

Investigative journalism NGO is a member of the following organizations:
* Since 2003: Global Investigative Journalism Network
* Since 2005: Association of European Journalists
* Since 2007: Organized Crime and Corruption Reporting Project (OCCRP)
# Șar (Mureș)

The Șar (Hungarian: Sár-patak) is a right tributary of the river Mureș in Romania. It discharges into the Mureș in Glodeni. Its name originates from the Hungarian "sár" meaning “mud”, so the Hungarian name means “Muddy Creek”. Its length is 20 km (12 mi) and its basin size is 103 km$^2$ (40 sq mi).
# Naoto Kidoku

Naoto Kidoku (寄特 直人, Kidoku Naoto, born May 12, 1994) is a Japanese football player.

## Career

Naoto Kidoku joined J2 League club Fagiano Okayama in 2013. In 2017, he moved to J3 League club SC Sagamihara.
# Leo Harlem

Leonardo González Feliz (born 16 November 1962), better known as Leo Harlem, is a Spanish comedian and late-blooming actor.

## Biography

Leonardo González Feliz (his real name) was born in Matarrosa del Sil [es] (province of León) on 16 November 1962, and moved to Valladolid with his family when he was a child. Following a participation in a El Club de la Comedia [es]'s monologue contest in 2001, he moved to Madrid to pursue a career as a comedian. He has since featured in comedy shows such as La hora de José Mota [es], Cómicos, algo más que los mejores monólogos, Antena3's El club del chiste [es] and Zapeando.
He made his feature film debut as an actor at age 52, featuring in a cameo performance in Santiago Segura's Torrente 5: Operación Eurovegas. After featuring in A Stroke of Luck in a supporting role playing the Mayor of the village where the fiction takes place in, Harlem landed his first lead role in 2018 comedy The Best Summer of My Life, playing Curro, a sleazy salesman who promises his son an unforgettable vacation.

## Filmography

Leo Harlem' film credits :
| Year | Title | Role | Notes |
| 2014 | Torrente 5: Operación Eurovegas | Vindicative camera control | Cameo appearance |
| 2016 | Villaviciosa de al lado | Anselmo | |
| 2018 | The Best Summer of My Life | Curro | |
| 2019 | Father There Is Only One | Uncle Paco | |
| 2019 | Off Course to China | Emilio | |
| 2020 | The Wedding Unplanner | Don Emilio | |
| 2020 | Superagente Makey | José Miguel "Makey" | |
| 2020 | Father There Is Only One 2 | Uncle Paco | Reprise of role in Padre no hay más que uno |
| 2021 | The Kids Are Alright | Felipe | |
| 2021 | Our (Perfect) Xmas Retreat | Luismi | |
| 2022 | Father There Is Only One 3 | Uncle Paco | Reprise of role in Padre no hay más que uno 2 |
| 2022 | Por los pelos, una historia de autoestima | Mateo | |
| 2023 | How to Become a Modern Man | Andrés Cuadrado | |
| 2023 | Vacaciones de verano | Oscar | |
| 2024 | Uncle Trouble | Toni | |
| 2024 | Father There Is Only One 4 | Uncle Paco | Reprise of role in Padre no hay más que uno 3 |
# Lavin, Iran

Lavin (Persian: لاوين, also Romanized as Lāvīn) is a village in Lahijan Rural District, in the Central District of Piranshahr County, West Azerbaijan Province, Iran. At the 2006 census, its population was 522, in 65 families.
# Mirnoye, Amur Oblast

Mirnoye (Russian: Мирное) is a rural locality (a selo) in Prigorodny Selsoviet of Belogorsky District, Amur Oblast, Russia. The population was 227 as of 2018. There are 3 streets.

## Geography

Mirnoye is located 25 km south of Belogorsk (the district's administrative centre) by road. Vozzhayevka is the nearest rural locality.
# Rui Kumada

Rui Kumada (熊田 瑠偉, Kumada Rui, born September 5, 1992) is a Japanese footballer who plays as a midfielder.
He was educated at and played for Withus Navi High School & Osaka Gakuin University before moving to Singapore in 2015. He extended his contract in 2015 to play for 2016 after a successful 2015 season.

## Club career statistics

As of January 2, 2016
| Club performance | Club performance | Club performance | League | League | Cup | Cup | League Cup | League Cup | Total | Total |
| Season | Club | League | Apps | Goals | Apps | Goals | Apps | Goals | Apps | Goals |
| Singapore | Singapore | Singapore | League | League | Singapore Cup | Singapore Cup | League Cup | League Cup | Total | Total |
| 2015 | Albirex Niigata FC (S) | S.League | 19 | 1 | 6 | 0 | 4 | 0 | 29 | 1 |
| 2016 | Albirex Niigata FC (S) | S.League | 18 | 3 | 5 | 1 | 5 | 1 | 28 | 5 |
| 2017 | Albirex Niigata FC (S) | S.League | ? | ? | ? | ? | ? | ? | ? | ? |
| Thailand | Thailand | Thailand | League | League | Thailand FA Cup | Thailand FA Cup | League Cup | League Cup | Total | Total |
| 2018 | Khon Kaen United F.C. | Thai League 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Total |
| Total | Singapore | Singapore | 37 | 4 | 11 | 1 | 9 | 1 | 57 | 6 |
| Career total | Career total | Career total | 37 | 4 | 11 | 1 | 9 | 1 | 57 | 6 |
# Fruzhin Peak

Fruzhin Peak (Bulgarian: връх Фружин, romanized: vrah Fruzhin, IPA:) is the peak rising to 1350 m in the south part of Petvar Heights, southeast Sentinel Range in Ellsworth Mountains, Antarctica. It overlooks Hudman Glacier to the west and Carey Glacier to the east.
The peak is named after the Bulgarian prince and military commander Fruzhin (14-15th century).

## Location

Fruzhin Peak is located at 78°50′27″S 84°16′40″W﻿ / ﻿78.84083°S 84.27778°W﻿ / -78.84083; -84.27778, which is 8.02 km east by south of Marze Peak, 6.04 km south-southeast of Miller Peak, 5.83 km west-southwest of Malkoch Peak and 9.5 km northwest of Mountainview Ridge. US mapping in 1961, updated in 1988.
# Takuya Koyama

Takuya Koyama (小山 拓哉, Koyama Takuya, born April 20, 1997) is a Japanese football player. He last played for FC Tokyo but has been without a club since 2017.

## Career

Takuya Koyama joined FC Tokyo in 2016. On May 29, he debuted in J3 League (v AC Nagano Parceiro).
# Hey Amigo! A Toast to Your Death

Hey Amigo! A Toast to Your Death (Italian: Ehi amigo... sei morto!, also known as Ehi amigo... Rest in Peace) is a 1970 Italian Spaghetti Western film directed by Paolo Bianchini and starring Wayde Preston.

## Plot

Dove Williams, a postal officer, pursues a gang of violent outlaws that rob a Texas stagecoach.

## Cast

* Wayde Preston as 'Doc' Williams
* Rik Battaglia as Barnett
* Aldo Berti as Black
* Agnès Spaak as Pachita
* Raf Baldassarre as Manolo
* Marco Zuanelli as El Loco
* Claudio De Davide as Nathaniel
* Franca Scagnetti as Nathaniel's Wife
# Hasserode Castle

Hasserode Castle (German: Burg Hasserode) in the quarter of the same name in the town of Wernigerode am Harz was a medieval fortification whose site is near Hasserode station on the Harz Narrow Gauge Railways. Today there are no visible traces left of the castle.

## Early history

The archival documented history of the Harz forests around the once independent municipality of Hasserode, that has been part of the borough of Wernigerode since 1907, go well back into the Middle Ages. Originally, this wooded region belonged to an imperial forest before it was enfeoffed by the Holy Roman emperors and German kings to the counts of Wernigerode, first mentioned in 1121, who came from Haimar in the Diocese of Hildesheim.
The counts of Wernigerode, like most ruling dynasties, endeavoured to extend their sphere of influence. In the Harz Foreland at the foot of the mountain range called the Huy they had freehold estates in various villages. These villages were, however, under the counts of Regenstein. In a clever move, the Wernigerode counts attempted to bind the subjects of these villages closer to them by granting timber rights in their forests in the Harz to the local farmers. For example, in 1253, there is already mention of the Hadebergeberg (now known as the Heudeberberg) south of the Augustine hermitage of Himmelpforten Abbey, destroyed in 1525. The Regenstein village of Heudeber was granted timber rights in this forest. Other villages were given similar rights by the counts of Wernigerode no later than the mid-14th century in the woods right and left of the Holtemme and in the Dränge valley. As well as Heudeber, the villages of Reddeber, Danstedt, Ströbeck, Athenstedt, Aspenstedt, Sargstedt and Runstedt also benefited.
These parishes, mainly located on the Huy, had certain privileges within a specified area of forest area, for which the expression Achtwort was coined at the beginning of the 15th century. In the circumstance of medieval Germany, the use of this forest area for these village which were approximately 10 to 30 kilometres away from the Harz, was very difficult. In order to protect them and better organize the management of the forest, a base at the foot of Harz was required.

## Sources

* Jacobs, Eduard (1882). Urkundenbuch der Deutschordens-Commende Langeln ..., Halle
* Sommer, Gustav and Jacobs, Eduard (1883). Beschreibende Darstellung der älteren Bau- und Kunstdenkmäler der Grafschaft Wernigerode. Halle
* Brückner, Jörg (1998). Die Burg Hasserode: zur Geschichte eines Rittersitzes am Fuße des Harzes. In: Burgen und Schlösser in Sachsen-Anhalt, Vol. 7, p. 26–41.
* Brückner, Jörg (1998). Prügelei brachte ein Kurfürstentum hervor: Neues über die Burg Hasserode. In: Neue Wernigeröder Ztg., Jg. 9, 1998, 6, p. 20
51°49′15″N 10°44′42″E﻿ / ﻿51.820833°N 10.745°E﻿ / 51.820833; 10.745
# Mezek Peak

Mezek Peak (Bulgarian: връх Мезек, romanized: vrah Mezek, IPA:) is a sharp peak rising to 1555 m in Imeon Range on Smith Island, South Shetland Islands. Situated 1.07 km east of Mount Pisgah and 4.02 km southwest by south of Mount Christi. Precipitous and predominantly ice-free east slopes. Overlooking Dalgopol Glacier to the northwest and Nosei Glacier to the east. Bulgarian early mapping in 2009. Named after the medieval fortress of Mezek in southeastern Bulgaria.
62°56′19″S 62°26′47″W﻿ / ﻿62.93861°S 62.44639°W﻿ / -62.93861; -62.44639

## Maps

* Chart of South Shetland including Coronation Island, &c. from the exploration of the sloop Dove in the years 1821 and 1822 by George Powell Commander of the same. Scale ca. 1:200000. London: Laurie, 1822.
* L.L. Ivanov. Antarctica: Livingston Island and Greenwich, Robert, Snow and Smith Islands. Scale 1:120000 topographic map. Troyan: Manfred Wörner Foundation, 2010. ISBN 978-954-92032-9-5 (First edition 2009. ISBN 978-954-92032-6-4)
* South Shetland Islands: Smith and Low Islands. Scale 1:150000 topographic map No. 13677. British Antarctic Survey, 2009.
* Antarctic Digital Database (ADD). Scale 1:250000 topographic map of Antarctica. Scientific Committee on Antarctic Research (SCAR). Since 1993, regularly upgraded and updated.
* L.L. Ivanov. Antarctica: Livingston Island and Smith Island. Scale 1:100000 topographic map. Manfred Wörner Foundation, 2017. ISBN 978-619-90008-3-0
# 2-Methyl-6-(phenylethynyl)pyridine

2-Methyl-6-(phenylethynyl)pyridine (MPEP) is a research drug which was one of the first compounds found to act as a selective antagonist for the metabotropic glutamate receptor subtype mGluR5. After being originally patented as a liquid crystal for LCDs, it was developed by the pharmaceutical company Novartis in the late 1990s. It was found to produce neuroprotective effects following acute brain injury in animal studies, although it was unclear whether these results were purely from mGluR5 blockade as it also acts as a weak NMDA antagonist, and as a positive allosteric modulator of another subtype mGlu4, and there is also evidence for a functional interaction between mGluR5 and NMDA receptors in the same populations of neurons. It was also shown to produce antidepressant and anxiolytic effects in animals, and to reduce the effects of morphine withdrawal, most likely due to direct interaction between mGluR5 and the μ-opioid receptor.
The main significance of MPEP has been as a lead compound to develop more potent and selective mGluR5 antagonists such as MTEP, but research using MPEP itself continues, and recently it was shown to reduce self-administration of nicotine, cocaine, ketamine and heroin in animals, possibly through an MPEP-induced potentiation of the rewarding effect of the self-administered drug, and MPEP was also shown to possess weak reinforcing effects by itself.