OpenLLM-France/wikimedia huggingface dataset:
# Hin recombinase

Hin recombinase is a 21kD protein composed of 198 amino acids that is found in the bacteria Salmonella. Hin belongs to the serine recombinase family (B2) of DNA invertases in which it relies on the active site serine to initiate DNA cleavage and recombination. The related protein, gamma-delta resolvase shares high similarity to Hin, of which much structural work has been done, including structures bound to DNA and reaction intermediates. Hin functions to invert a 900 base pair (bp) DNA segment within the salmonella genome that contains a promoter for downstream flagellar genes, fljA and fljB. Inversion of the intervening DNA alternates the direction of the promoter and thereby alternates expression of the flagellar genes. This is advantageous to the bacterium as a means of escape from the host immune response.
Hin functions by binding to two 26bp imperfect inverted repeat sequences as a homodimer. These hin binding sites flank the invertible segment which not only encodes the Hin gene itself, but also contains an enhancer element to which the bacterial Fis proteins binds with nanomolar affinity. Four molecules of Fis bind to this site as a homodimers and are required for the recombination reaction to proceed.
The initial reaction requires binding of Hin and Fis to their respective DNA sequences and assemble into a higher-order nucleoprotein complex with branched plectonemic supercoils with the aid of the DNA bending protein HU. At this point, it is believed that the Fis protein modulates subtle contacts to activate the reaction, possibly through direct interactions with the Hin protein. Activation of the 4 catalytic serine residues within the Hin tetramer make a 2-bp double stranded DNA break and forms a covalent reaction intermediate. The DNA cleavage event also requires the divalent metal cation magnesium. A large conformational change reveals a large hydrophobic interface that allows for subunit rotation which may be driven by superhelical torsion within the protein-DNA complex. After this 180° rotation, Hin returns to its native conformation and re-ligates the cleaved DNA, without the aid of high energy cofactors and without the loss of any DNA.
# Hines '74

Hines '74 is an album by pianist Earl Hines recorded in France in 1974 for the Black & Blue label.

## Reception

Professional ratings :
| Review scores ||
| Source | Rating |
| AllMusic | |
Allmusic awarded the album 4 stars stating "Even though this enjoyable date is not the best starting point for a jazz fan who is just beginning to explore the recorded legacy of Earl Hines, those already familiar with his work will enjoy this".

## Track listing

* "Tangerine" (Victor Schertzinger, Johnny Mercer) - 3:19
* "There'll Be Some Changes Made" (W. Benton Overstreet, Billy Higgins) - 7:57
* "You're Driving Me Crazy" (Walter Donaldson) - 7:06
* "Makin' Whoopee" (Donaldson, Gus Kahn) - 8:46
* "My Buddy" (Donaldson, Kahn) - 9:24

## Personnel

* Earl Hines - piano
* Jimmy Leary - bass
* Panama Francis - drums
# 1999–2000 Logan Cup

The 1999–2000 Logan Cup was a first-class cricket competition held in Zimbabwe from 3 March 2000 – 7 April 2000. It was won by Mashonaland, who beat Manicaland in the final having finished second behind them in the league stage of the competition.

## Points table

| Team | Pld | W | L | D | Bat | Bwl | Pts |
| Manicaland | 4 | 2 | 0 | 2 | 5 | 16 | 51 |
| Mashonaland | 4 | 2 | 0 | 2 | 6 | 14 | 50 |
| CFX Academy | 4 | 1 | 0 | 3 | 6 | 15 | 42 |
| Midlands | 4 | 1 | 3 | 0 | 1 | 12 | 25 |
| Matabeleland | 4 | 0 | 3 | 1 | 4 | 16 | 23 |
| Source:CricketArchive ||||||||

## Final

* 7–9 April 2000 Scorecard
* Mashonaland won by 257 runs Harare Sports Club, Harare Umpires: Ian Robinson and Russell Tiffin
* Manicanaland won the toss and elected to field.
# Pseudaneitea delli

Pseudaneitea delli is an air-breathing land slug, specifically a leaf-veined slug, a terrestrial gastropod mollusc in the family Athoracophoridae.
# Owen Roberts (aviator)

Owen Roberts (also known as "The Commander") (17 September 1912 – 10 April 1953) was a British Royal Air Force officer, aviator and founder of Caribbean International Airways.

## Early life

George Marshall Endicott Roberts was born on 17 September 1912 in London. He was a son of the former Irene Helene Murray (1882–1972) and Marshall Owen Roberts (1878–1931), an American who became a British subject.
His paternal grandparents were wealthy American businessman Marshall Owen Roberts, and the former Sarah Lawrence "Susan" Endicott. His maternal grandparents were Sir George Murray (great-grandson of the Lord George Murray, second son of John Murray, 3rd Duke of Atholl) and the former Helen Mary Mulholland (a daughter of 1st Baron Dunleath).

## Career

Roberts flew with the RAF and was a wing commander during World War II.
ST-12 Monospar G-ADLL was purchased by Captain Owen Roberts who entered it into the King Cup air race of 1935 and was placed 19th out of 20. Painted all gold it undertook a world tour and flew across America to California. Eventually it returned bearing the many flags of the countries it had traversed. The plane was kept by Capt Roberts until it was impressed into service at the outbreak of war as X9431. It first went to No-110 Wing (Anti-Aircraft Co-operation Unit) where the gold paint was replaced with camouflage paint. In May 1940 it was allocated to Ringway where it was employed with No-7 AACU.
Following the war, Roberts co-founded Caribbean International Airways (CIA). By 1950, Roberts had established regular service between Cayman and Tampa, Florida; Kingston, Jamaica; and Belize. He worked to lobby Cayman Islands Commissioners Ivor Smith and Andrew Gerrard to build airfields on all three of the Cayman Islands. In 1952, construction started on an official airstrip at an estimated cost of £93,000. On 28 November 1952 with a crowd of several hundred onlookers, Roberts piloted a PBY Catalina to a perfect landing on the partially completed airport runway. Within six months after that landing, Roberts had acquired two used Lockheed Lodestar airliners purchased to keep up with the competition whose interest was now piqued by the soon-to-be completed airfield at George Town.

## Personal life

In 1936, Roberts was married to Patricia Charles, they had two daughters who lived in London: During a CIA flight from Kingston, Jamaica to Grand Cayman on 10 April 1953, the Lodestar piloted by Roberts crashed on takeoff from Palisadoes Airport, killing thirteen of the fourteen people on board, including Roberts and his sister. The only survivor of the crash was Roberts' brother-in-law, Lt.-Col. Edward Remington-Hobbs.

### Legacy

Owen Roberts International Airport in George Town on Grand Cayman in the Cayman Islands is named after him.
# Millership

Millership is a surname. Notable people with the surname include:
* Harry Millership (1889–1959), British footballer
* Walter Millership (1910–1978), British footballer
# Mike Brumley

Mike Brumley may refer to:
* Mike Brumley (catcher) (1938–2016), former catcher in Major League Baseball
* Mike Brumley (infielder) (1963–2024), his son, former utility player in Major League Baseball
# Hierodula biaka

Hierodula biaka is a species of praying mantis in the family Mantidae.
# Hines

Hines may refer to:

## Places in the United States

* Hines, Florida, an unincorporated community in Dixie County
* Hines, Illinois, an unincorporated community
* Hines, Minnesota, an unincorporated community
* Hines Township, Beltrami County, Minnesota
* Hines, Oregon, a city
* Hines, West Virginia, an unincorporated community
* Hines, Wisconsin, an unincorporated community

## People

* Hines (name), a list of people with the surname or given name

## Other

* Hines Interests Limited Partnership, an international real estate company
# Hasnain Aaqib

Khan Hasnain Aaqib is a renowned Urdu, Hindi, and English poet who has as many as 17 published books to his credit so far. He is primarily known for writing Ghazals and Nazm in Urdu, Hindi and Persian languages. He is the member of the Urdu and Persian language committee of Balbharti, Pune. His Persian poetry is largely acknowledged in Persian speaking regions as well. He is credited for coining the term PROPHIEM for the genre of poems denoting the praise and biographic account of the Islamic prophet Muhammad. He is also the one who coined the term REFLECTIVE TRANSLATION for the work of literary and academic translation from one's mother tongue into any other language which is not the mother tongue of the translator. He initiated the movement insisting upon this term to be categorized and called as REFLECTIVE TRANSLATION

## Early life

Being born in Akola, Hasnain Aaqib spent his childhood in the same city. He is the eldest one among his ten siblings including six sisters and four brothers. Hasnain's mother died very young when he was hardly seven years old leaving behind her four children. His father Mohammad Shahbaz Khan married again begetting another set of six children with his second wife. He belonged to an economically moderate family. His grandfather Mohammad Mirbaz Khan aka Baba Taj Mastan was a mystic. Hasnain's father Mohammad Shahbaz Khan brought him up in a very disciplined manner. Hasnain graduated and earned his B.Ed. from Akola. During his schooling days, his family's economic condition had begun to deteriorate. This forced him and his younger brother Ali Raza to start working at an early age. Both the brothers began to pull the cart of the family and bear the burden of the younger siblings along with their father. It was during these days of hardship that he began to explore the various modes of expressing himself. He finally settled with writing poetry in English and Urdu.

## Career

Hasnain Aaqib joined Taj K.G and English High School in Akola as a teacher immediately after completing his graduation. After his marriage, he moved to Pusad and joined G.N.Azad Jr. College of Education as lecturer in 1999 where he is still working in the same capacity.
# Pseudaneitea gigantea

Pseudaneitea gigantea is a species of air-breathing land slug, a terrestrial gastropod mollusc in the family Athoracophoridae, the leaf-veined slugs. It was first described by Henry Suter in 1909.
# Hierocrypt

In cryptography, Hierocrypt-L1 and Hierocrypt-3 are block ciphers created by Toshiba in 2000. They were submitted to the NESSIE project, but were not selected. Both algorithms were among the cryptographic techniques recommended for Japanese government use by CRYPTREC in 2003, however, both have been dropped to "candidate" by CRYPTREC revision in 2013.
The Hierocrypt ciphers are very similar, differing mainly in block size: 64 bits for Hierocrypt-L1, 128 bits for Hierocrypt-3. Hierocrypt-L1's key size is 128 bits, while Hierocrypt-3 can use keys of 128, 192, or 256 bits. The number of rounds of encryption also varies: Hierocrypt-L1 uses 6.5 rounds, and Hierocrypt-3 uses 6.5, 7.5, or 8.5, depending on the key size.
The Hierocrypt ciphers use a nested substitution–permutation network (SPN) structure. Each round consists of parallel applications of a transformation called the XS-box, followed by a linear diffusion operation. The final half-round replaces the diffusion with a simple post-whitening. The XS-box, which is shared by the two algorithms, is itself an SPN, consisting of a subkey XOR, an S-box lookup, a linear diffusion, another subkey XOR, and another S-box lookup. The diffusion operations use two MDS matrices, and there is a single 8×8-bit S-box. The key schedule uses the binary expansions of the square roots of some small integers as a source of "nothing up my sleeve numbers".
No analysis of the full ciphers has been announced, but certain weaknesses were discovered in the Hierocrypt key schedule, linear relationships between the master key and some subkeys. There has also been some success applying integral cryptanalysis to reduced-round Hierocrypt variants; attacks faster than exhaustive search have been found for 3.5 rounds of each cipher.
# Hennesy

Hennesy is a surname. Notable people with the surname include:
* Carolyn Hennesy (born 1962), American actress and writer
* Dale Hennesy (1926–1981), American art director
* Sean Hennesy, American guitarist
* Tom Hennesy (1923–2011), American actor and stuntman
# Grégory Saint-Géniès

Grégory Saint-Géniès (born 23 May 1977 in Maisons-Alfort) is a French skeleton racer who has competed since 2002. His best World Cup finish was 18th in the men's event twice (2005, 2009).
Saint-Géniès' best finish at the FIBT World Championships was 16th in the men's event at St. Moritz in 2007.
He competed at the 2010 Winter Olympics where he finished 15th.
# Pancreatic islet macrophage

Islet resident macrophages are the predominant myeloid cell of the pancreatic islets of langerhans.

## Structure
### Markers

Islet resident macrophages are uniquely found within the endocrine tissue (islet), while nearby in the nearby acinar tissue, macrophages express a different repertoire of CD (cluster of differentiation) markers and come from a different developmental origin. In terms of expression markers, islet macrophages are positive for; F4/80, CD11b, CD11c, MHC-II, CD64, CD68, LyzM (lysozyme), Cx3cr1 and are negative for; CD206 (mannose receptor), CD301, CD103.

### Development

The mesoderm gives rise to myeloid progenitor cells, which further differentiate into macrophage populations. As opposed to macrophages in the islet stroma (tissue), whose developmental origin is from the yolk sac (primitive hematopoiesis), islet resident progenitors come from hematopoietic stem cells (HSCs) of the definitive hematopoiesis. These cells are seen in fetal liver during mid-gestation E10-E11, and are thought to colonize the bone marrow during late gestation E15. As a unique population in terms of developmental origin, these resident macrophages have a unique phenotype in which they are long lived, self-renew locally, and stay confined within the islet parenchyma.

## Function

Islet resident macrophages depend on the expression of colony stimulating factor (CSF1). Knockout mice for the CSF-1 gene cause islets to be devoid of resident macrophages. These mice show a reduced beta cell mass as well as developmental defects. This as well as other observations, showing that islet resident macrophages promote beta cell proliferation suggest that islet macrophages are likely important contributors to the function of the pancreatic islet. In contrast to the possible supportive role within the islet, these specialized macrophages are also required for the initiation of the adaptive immune response during type 1 diabetes (T1D) in mice. They do this by presenting beta cell derived peptides using MHC II receptors to T-cells in the islet. Once activated, T-cells stimulate the adaptive immune system, which leads to the destruction of pancreatic islets due to an autoimmune response.

## History

The islet resident macrophage was first identified in 1979 as an antigen-presenting cell (APC), which expresses major histocompatibility complexes (MHCs). Later in 1984 this APC was further classified by using a macrophage specific marker F4/80. In 1988 it was discovered that macrophages play an essential role in the progression of insulin dependent diabetes mellitus (T1D), in an animal model for non-obese diabetes (NOD mice). The role of pancreatic macrophages were later shown to play an important role in type 2 diabetes as well, by contributing to islet inflammation. The origin and turnover in the normal state was characterized by Emil Unanue in 2015.
# Mikkalo, Oregon

Mikkalo is an unincorporated community in Gilliam County, Oregon, United States, at an elevation of 1,470 feet (450 m). Mikkalo is about 4 miles (6.4 km) northwest of Clem. Mikkalo has a post office, serving ZIP code of 97861, and is in the 541 area code region. In 1905, the place was named for settler John Mikkalo, and a post office opened at Mikkalo in 1907. It was along the Condon Branch of the Union Pacific Railroad. The Mikkalo Farmers Elevator had a fire on March 28, 1921.
This region experiences warm (but not hot) and dry summers, with no average monthly temperatures above 71.6 °F (22.0 °C). According to the Köppen Climate Classification system, Mikkalo has a warm-summer Mediterranean climate, abbreviated "Csb" on climate maps.
# Marcos "Barrão" DaSilva

Marcos "Barrão" DaSilva (born 1961) is a Brazilian capoeira mestre (master) and founder of Grupo Axé Capoeira, which has schools worldwide. He began Grupo Axé officially in 1982 in Vancouver and since has had schools established around the world.

## First Mestre: Mestre Pirajá

Marcos "Barrão" DaSilva was born in Recife in 1961 into a state of poverty. He displayed an early talent for the drums, with which he earned his keep as a lad. At the age of 13, Mestre Pirajá (who was taught by his brother, a student of Mestre Bimba) took young Marcos under his wing and started to teach him Capoeira. An academy capoeirista by trade, Mestre Pirajá taught Barrão the discipline and techniques of Capoeira.

## Legacy

Mestre Barrão began to enter tournaments and became the Brazilian Champion in the National Capoeira Championships in Rio de Janeiro. He opened his school, Grupo Axé Capoeira, in 1982. In 1987, he was given the rank of 1st Degree Mestre by Pirajá. He then moved to Vancouver and opened an academy there. In 2007, he launched an academy in his hometown of Recife and he currently resides there.
Mestre Barrão has been invited to teach and conduct workshops and batizados all over the world. He is the recipient of many awards. He was instrumental in re-introducing a dance known as Coco de Roda.
He continues to contribute to the development of Capoeira and passes on his philosophy to all 20,000 members of his school.
# Hatteng

Hatteng (Norwegian), Háhtta (Northern Sami), or Hattu (Kven) is the administrative centre of Storfjord Municipality in Troms county, Norway. The village is located along the European route E06 highway at the southern end of the Storfjorden, a branch of the large Lyngenfjorden. Storfjord Church is located in Hatteng.
Hatteng sits about 20 kilometres (12 mi) northeast of the village of Nordkjosbotn (in Balsfjord Municipality) and about 33 kilometres (21 mi) northwest of the Treriksröset cairn where the borders of Norway, Sweden, and Finland meet.
Immediately west of Hatteng lies the village of Oteren.
# Pseudaneitea gravisulca

Pseudaneitea gravisulca is a species of air-breathing land slug, a terrestrial gastropod mollusc in the family Athoracophoridae, the leaf-veined slugs.
# Pain Awareness Month

September is Pain Awareness Month in the United States. The American Chronic Pain Association (ACPA) declared this month to “raise public awareness of issues in the area of pain and pain management.”

## History

In 2001, the ACPA led a coalition of groups to create the first Pain Awareness Month. These groups, including the NAACP and the American Cancer Society, assembled under the umbrella of the Partners for Understanding Pain.
In 2002, the ACPA presented a kickoff lunch for the coalition at the International Association for the Study of Pain Conference, and by 2003 the Partners for Understanding Pain had expanded to include more than 30 partner organizations. 2004’s event was held in Washington, D.C. and featured a keynote presentation by United States Representative Mike Rogers (R-Michigan), who was the sponsor of HR 1863, The National Pain Care Policy Act of 2003.
2004 was also the year the ACPA and the Partners for Understanding Pain issued their first toolkit, developed with The American Academy of Nurse Practitioners, the American Association of Rehabilitations Nurses, American Nurses Association, American Society of Pain Management Nurses, and the American Society of Perianesthesia Nurses.
2005 saw the release of another toolkit, this one emphasizing the role pharmacists play in pain management. This year, the ACPA and the Partners for Understanding Pain also visited congressional representatives in support of HR 1020: The National Pain Care Policy Act of 2005.
By 2006, the ACPA and their partners had released three tool kits, one each for nurses, pharmacists, and older adults. Seeing the monthly observance well established, the ACPA in 2007 shifted focus to a more grassroots approach working with local facilitators and members to raise awareness in the media on the causes of pain and to remove the stigma associated with seeking treatment.

## Resources

In association with Pain Awareness Month, the ACPA provides the following resources:
* Communication tools to assist patients with talking to medical professionals
* Pain Awareness toolkits
* Pain Management Programs information
# Helvy Tiana Rosa

Helvy Tiana Rosa (born 2 April 1970) is an Indonesian playwright and writer. She is notable for founding and being the first chairwoman of the Pen Circle Forum (Indonesian: Forum Lingkar Pena), a well-known Indonesian literary forum.
The Royal Islamic Strategies Studies Centre, of the Royal Aal al-Bayt Institute for Islamic Thought, featured her in the 10th anniversary edition of The Muslim 500.

## Life

Rosa was born in Medan in 1970 but she moved to Jakarta where her younger sister Asma Nadia, who also became a writer, was born. She went to the Universitas Indonesia and gained a degree in Arabic literature. Whilst at university she wrote and directed her own plays. She has gained a master's degree. Rosa married Widanardi Satryatomo in 1995.
Her short story "The Red Nets" (Jaring-jaring Merah) was chosen as one of the most important of the 1990s by the influential magazine Horison. She has published over 50 works which have been translated into English, German, Arabic, Swedish, Japanese and French. She founded the website for young writers named Forum Lingkar Pena and she edited the magazine for Islamic teenagers known as Annida. She is known for taking a Muslim approach to her work. She writes of how woman live in an Islamic culture run by men. She writes against the permissive use of pornography.
Rosa has been included in a list of the 500 most influential Muslims.
# Mark Newman (disambiguation)

Mark Newman is an English-American physicist.
Mark Newman may also refer to:
* Mark Newman (baseball) (1949–2020), American professional baseball executive
* Mark Newman (educator) (1772–1859), American educator, deacon, and publisher
* Mark Newman (sculptor), American