# 2022 Columbus Challenger – Singles

Stefan Kozlov was the defending champion but lost in the second round to Dominic Stricker.
Yoshihito Nishioka won the title after defeating Stricker 6–2, 6–4 in the final.

## Seeds

* Jenson Brooksby (semifinals)
* Tennys Sandgren (first round)
* Yoshihito Nishioka (champion)
* Jurij Rodionov (semifinals)
* Ernesto Escobedo (quarterfinals)
* Emilio Gómez (quarterfinals)
* Jack Sock (quarterfinals, withdrew)
* Bjorn Fratangelo (second round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 1/WC | Jenson Brooksby | 3 | 4 | | | | | |
| 3 | Yoshihito Nishioka | 6 | 6 | | | | | |
| 3 | Yoshihito Nishioka | 6 | 6 | | 3 | Yoshihito Nishioka | 6 | 6 |
| | | | | | | Dominic Stricker | 2 | 4 |
| 4 | Jurij Rodionov | 4 | 6 | 4 | | Dominic Stricker | 2 | 4 |
| | Dominic Stricker | 6 | 2 | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1/WC | J Brooksby | 2 | 6 | 7 | | | | | | | | | | | | | | |
| | M Krueger | 6 | 3 | 5 | 1/WC | J Brooksby | 7 | 6 | | | | | | | | | | |
| | D Istomin | 7 | 1 | 6 | | D Istomin | 5 | 1 | | | | | | | | | | |
| Q | S Fanselow | 5 | 6 | 4 | | | | | | 1/WC | J Brooksby | 6 | 1 | 6 | | | | |
| | U Blanch | 7$^9$ | 6 | | | | | | | 5 | E Escobedo | 4 | 6 | 1 | | | | |
| Q | R Quiroz | 6$^7$ | 4 | | | U Blanch | 6$^8$ | 4 | | | | | | | | | | |
| | J Jung | 1 | 4 | | 5 | E Escobedo | 7$^{10}$ | 6 | | | | | | | | | | |
| 5 | E Escobedo | 6 | 6 | | | | | | | | | | | | 1/WC | J Brooksby | 3 | 4 |
| 3 | Y Nishioka | 6 | 6 | | | | | | | | | | | | 3 | Y Nishioka | 6 | 6 |
| Q | Yo Watanuki | 4 | 4 | | 3 | Y Nishioka | 6 | 2 | 6 | | | | | | | | | |
| | J. J. Wolf | 6 | 6 | | | J. J. Wolf | 2 | 6 | 4 | | | | | | | | | |
| WC | Jack Anthrop | 0 | 3 | | | | | | | 3 | Y Nishioka | 6 | 4 | 6 | | | | |
| | Y Uchiyama | 6$^6$ | 4 | | | | | | | 6 | E Gómez | 1 | 6 | 3 | | | | |
| | N Kuhn | 7$^8$ | 6 | | | N Kuhn | 6$^6$ | 5 | | | | | | | | | | |
| | G Blancaneaux | 5 | 5 | | 6 | E Gómez | 7$^8$ | 7 | | | | | | | | | | |
| 6 | E Gómez | 7 | 7 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 8 | B Fratangelo | 6 | 6 | | | | | | | | | | | | | | | | |
| Q | N Mejía | 1 | 2 | | 8 | B Fratangelo | 1 | 4 | | | | | | | | | | | |
| | M Torpegaard | 6 | 7$^7$ | | | M Torpegaard | 6 | 6 | | | | | | | | | | | |
| | M Mmoh | 4 | 6$^3$ | | | | | | | | M Torpegaard | 7$^7$ | 5 | 3$^r$ | | | | | |
| Q | N Hardt | 6 | 7$^7$ | | | | | | | 4 | J Rodionov | 6$^1$ | 7 | 4 | | | | | |
| Q | R Harrison | 4 | 6$^3$ | | Q | N Hardt | 3 | 2 | | | | | | | | | | | |
| | B Schnur | 4 | 7 | 5 | 4 | J Rodionov | 6 | 6 | | | | | | | | | | | |
| 4 | J Rodionov | 6 | 5 | 7 | | | | | | | | | | | 4 | J Rodionov | 4 | 6 | 4 |
| 7 | J Sock | 7$^9$ | 6$^4$ | 6 | | | | | | | | | | | | D Stricker | 6 | 2 | 6 |
| | C Eubanks | 6$^7$ | 7$^7$ | 4 | 7 | J Sock | 6 | 6 | | | | | | | | | | | |
| | G Soeda | 7$^7$ | 6 | | | G Soeda | 3 | 4 | | | | | | | | | | | |
| PR | T-l Wu | 6$^5$ | 2 | | | | | | | 7 | J Sock | | | | | | | | |
| WC | Alexander Bernard | 2 | 1 | | | | | | | | D Stricker | w/o | | | | | | | |
| | S Kozlov | 6 | 6 | | | S Kozlov | 6 | 4 | 3 | | | | | | | | | | |
| | D Stricker | 6 | 6$^3$ | 7$^7$ | | D Stricker | 4 | 6 | 6 | | | | | | | | | | |
| 2 | T Sandgren | 4 | 7$^7$ | 6$^0$ | | | | | | | | | | | | | | | |