# 2016 Milo Open Cali – Singles

Fernando Romboli was the defending champion but chose not to participate.
Darian King won the title after defeating Víctor Estrella Burgos 5–7, 6–4, 7–5 in the final.

## Seeds

* Víctor Estrella Burgos (final)
* Alejandro González (first round)
* Gonzalo Lama (first round)
* Eduardo Struvay (second round)
* João Souza (quarterfinals)
* Marcelo Arévalo (first round)
* Darian King (champion)
* Juan Ignacio Londero (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| 1 | Víctor Estrella Burgos | 6 | 6 | | | | | |
| | Federico Coria | 3 | 2 | | | | | |
| | Federico Coria | 3 | 2 | 1 | Víctor Estrella Burgos | 7 | 4 | 5 |
| | | | | 7 | Darian King | 5 | 6 | 7 |
| | José Hernández | 6$^3$ | 3 | 7 | Darian King | 5 | 6 | 7 |
| 7 | Darian King | 7$^7$ | 6 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | V Estrella Burgos | 6 | 6 | | | | | | | | | | | | | | |
| WC | Felipe Mantilla | 3 | 2 | | 1 | V Estrella Burgos | 6 | 6 | | | | | | | | | |
| | D Dutra da Silva | 3 | 4 | | Q | N Jarry | 4 | 4 | | | | | | | | | |
| Q | N Jarry | 6 | 6 | | | | | | | 1 | V Estrella Burgos | 6 | 0 | | | | |
| | Erik Crepaldi | 7$^7$ | 6 | | | | | | | | N Barrientos | 3 | 0$^r$ | | | | |
| | Connor Smith | 6$^5$ | 2 | | | E Crepaldi | 2 | 2 | | | | | | | | | |
| | N Barrientos | 1 | 6 | 6 | | N Barrientos | 6 | 6 | | | | | | | | | |
| 8 | JI Londero | 6 | 0 | 4 | | | | | | | | | | 1 | V Estrella Burgos | 6 | 6 |
| 4 | E Struvay | 6 | 4 | 6 | | | | | | | | | | | F Coria | 3 | 2 |
| | DE Galán | 3 | 6 | 1 | 4 | E Struvay | 5 | 4 | | | | | | | | | |
| Q | MT Barrios Vera | 6 | 6 | | Q | MT Barrios Vera | 7 | 6 | | | | | | | | | |
| Q | JS Gómez | 4 | 2 | | | | | | | Q | MT Barrios Vera | 3 | 3 | | | | |
| | L Gómez | 6 | 5 | 5 | | | | | | | F Coria | 6 | 6 | | | | |
| | F Coria | 3 | 7 | 7 | | F Coria | 1 | 6 | 7$^{12}$ | | | | | | | | |
| | E Gómez | 7$^7$ | 6 | | | E Gómez | 6 | 3 | 6$^{10}$ | | | | | | | | |
| 6 | M Arévalo | 6$^4$ | 3 | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 5 | J Souza | 6 | 6 | | | | | | | | | | | | | |
| | H Podlipnik | 2 | 2 | 5 | J Souza | 6 | 6 | | | | | | | | | |
| | F Mena | 6 | 6 | | F Mena | 4 | 2 | | | | | | | | | |
| PR | C Salamanca | 2 | 1 | | | | | 5 | J Souza | 4 | 6 | 6$^4$ | | | | |
| | J Hernández | 6 | 6 | | | | | | J Hernández | 6 | 3 | 7$^7$ | | | | |
| | Maximiliano Estévez | 0 | 2 | | J Hernández | 6 | 6 | | | | | | | | | |
| Q | R Quiroz | 6 | 6 | Q | R Quiroz | 2 | 3 | | | | | | | | | |
| 3 | G Lama | 4 | 4 | | | | | | | | | | | J Hernández | 6$^3$ | 3 |
| 7 | D King | 6 | 6 | | | | | | | | | | 7 | D King | 7$^7$ | 6 |
| | A Gómez | 4 | 0 | 7 | D King | 7 | 6 | | | | | | | | | |
| WC | G Lapentti | 7 | 7$^7$ | WC | G Lapentti | 5 | 2 | | | | | | | | | |
| | C Díaz Figueroa | 5 | 6$^4$ | | | | | 7 | D King | 6 | 5 | 6 | | | | |
| WC | C Rodríguez | 6 | 6 | | | | | WC | C Rodríguez | 4 | 7 | 1 | | | | |
| WC | N Mejía | 4 | 3 | WC | C Rodríguez | 6 | 6 | | | | | | | | | |
| | A Santillan | 6 | 7 | | A Santillan | 4 | 3 | | | | | | | | | |
| 2 | A González | 3 | 5 | | | | | | | | | | | | | |