# 2022 Challenger de Santiago – Singles

Sebastián Báez was the defending champion but chose not to defend his title.
Hugo Dellien won the title after defeating Alejandro Tabilo 6–3, 4–6, 6–4 in the final.

## Seeds

* Jiří Lehečka (quarterfinals)
* Alejandro Tabilo (final)
* Hugo Dellien (champion)
* Juan Pablo Varillas (semifinals)
* Tomás Martín Etcheverry (semifinals)
* Juan Ignacio Londero (second round)
* Nicolás Jarry (first round)
* Tomás Barrios Vera (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| 5 | Tomás Martín Etcheverry | 3 | 7$^7$ | 4 | | | | | |
| 3 | Hugo Dellien | 6 | 6$^3$ | 6 | | | | | |
| 3 | Hugo Dellien | 6 | 6$^3$ | 6 | 3 | Hugo Dellien | 6 | 4 | 6 |
| | | | | | 2 | Alejandro Tabilo | 3 | 6 | 4 |
| 4 | Juan Pablo Varillas | 6$^6$ | 1 | | 2 | Alejandro Tabilo | 3 | 6 | 4 |
| 2 | Alejandro Tabilo | 7$^8$ | 6 | | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | J Lehečka | 6 | 6 | | | | | | | | | | | | | | | |
| Q | M Martineau | 3 | 2 | | 1 | J Lehečka | 6 | 3 | 6 | | | | | | | | | |
| | S Rodríguez Taverna | 2 | 1 | | | G Oliveira | 3 | 6 | 3 | | | | | | | | | |
| | G Oliveira | 6 | 6 | | | | | | | 1 | J Lehečka | 4 | 3 | | | | | |
| WC | D Fernández Flores | 3 | 1 | | | | | | | 5 | TM Etcheverry | 6 | 6 | | | | | |
| | C Ugo Carabelli | 6 | 6 | | | C Ugo Carabelli | 1 | 6 | 5 | | | | | | | | | |
| Q | E Furness | 5 | 2 | | 5 | TM Etcheverry | 6 | 4 | 7 | | | | | | | | | |
| 5 | TM Etcheverry | 7 | 6 | | | | | | | | | | | 5 | TM Etcheverry | 3 | 7$^7$ | 4 |
| 3 | H Dellien | 2 | 7$^7$ | 6 | | | | | | | | | | 3 | H Dellien | 6 | 6$^3$ | 6 |
| | P Cachin | 6 | 6$^4$ | 1 | 3 | H Dellien | 6 | 6 | | | | | | | | | | |
| | R Olivo | 6 | 6 | | | R Olivo | 3 | 4 | | | | | | | | | | |
| WC | Ignacio Becerra | 2 | 0 | | | | | | | 3 | H Dellien | 6 | 6 | | | | | |
| Q | H Casanova | 1 | 6 | 2 | | | | | | | J de Jong | 3 | 3 | | | | | |
| Q | P Jubb | 6 | 2 | 6 | Q | P Jubb | 5 | 3 | | | | | | | | | | |
| | J de Jong | 6 | 7$^7$ | | | J de Jong | 7 | 6 | | | | | | | | | | |
| 8 | T Barrios Vera | 1 | 6$^0$ | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 6 | JI Londero | 6 | 7$^7$ | | | | | | | | | | | | | | | |
| | A Collarini | 0 | 6$^5$ | | 6 | JI Londero | 7$^7$ | 2 | 5 | | | | | | | | | |
| | M Pucinelli de Almeida | 6 | 3 | 6 | | M Pucinelli de Almeida | 6$^5$ | 6 | 7 | | | | | | | | | |
| | GA Olivieri | 3 | 6 | 3 | | | | | | | M Pucinelli de Almeida | 5 | 2 | | | | | |
| LL | D Dutra da Silva | 4 | 2 | | | | | | | 4 | JP Varillas | 7 | 6 | | | | | |
| Q | JB Torres | 6 | 6 | | Q | JB Torres | 1 | 3 | | | | | | | | | | |
| | TA Tirante | 4 | 3 | | 4 | JP Varillas | 6 | 6 | | | | | | | | | | |
| 4 | JP Varillas | 6 | 6 | | | | | | | | | | | | 4 | JP Varillas | 6$^6$ | 1 |
| 7 | N Jarry | 6 | 6$^3$ | 3 | | | | | | | | | | | 2 | A Tabilo | 7$^8$ | 6 |
| | V Kopřiva | 1 | 7$^7$ | 6 | | V Kopřiva | 6 | 4 | 7 | | | | | | | | | |
| | F Mena | 3 | 4 | | | N Kicker | 4 | 6 | 5 | | | | | | | | | |
| | N Kicker | 6 | 6 | | | | | | | | V Kopřiva | 2 | 6 | 3 | | | | |
| Q | Facundo Juárez | 2 | 7$^7$ | 1 | | | | | | 2 | A Tabilo | 6 | 4 | 6 | | | | |
| | G Lama | 6 | 6$^4$ | 6 | | G Lama | 1 | 2 | | | | | | | | | | |
| WC | Daniel Antonio Núñez | 5 | 0 | | 2 | A Tabilo | 6 | 6 | | | | | | | | | | |
| 2 | A Tabilo | 7 | 6 | | | | | | | | | | | | | | | |