OpenLLM-France/wikimedia huggingface dataset:
# Prolyl endopeptidase

Prolyl endopeptidase (PE) also known as prolyl oligopeptidase or post-proline cleaving enzyme is an enzyme that in humans is encoded by the PREP gene.

## Function

Prolyl endopeptidase is a large cytosolic enzyme that belongs to a distinct class of serine peptidases. It was first described in the cytosol of rabbit brain as an oligopeptidase, which degrades the nonapeptide bradykinin at the Pro-Phe bond. The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides such as alpha-melanocyte-stimulating hormone, luteinizing hormone-releasing hormone (LH-RH), thyrotropin-releasing hormone, angiotensin, neurotensin, oxytocin, substance P and vasopressin. PREP cleaves peptide bonds at the C-terminal side of proline residues. Its activity is confined to action on oligopeptides of less than 10 kD and it has an absolute requirement for the trans-configuration of the peptide bond preceding proline.
Prolyl endopeptidases are involved in the maturation and degradation of peptide hormones and neuropeptides.

## Structure

Prolyl endopeptidase is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Only short protein residues are able to enter the active site of prolyl endopeptidase due to the distinct beta-propeller region that acts as a gating filter mechanism.
Prolyl endopeptidase was also found to be involved in the metabolism of VHL-PROTACs in in vitro studies.

## Clinical significance

Altered PREP activity may be associated with autism spectrum disorders and various psychological diseases such as schizophrenia, mania and clinical depression.
However, there is conflicting information as to the exact role that prolyl endopeptidase plays in the pathophysiology of depression, with earlier studies documenting a decreased activity of the enzyme in depressed patients, but more recent studies demonstrating that inhibition of the same enzyme actually results in alleviation of depressive symptoms.
Some types of prolyl endopeptidase have been used in studies to decrease the propensity of gluten-containing wheat products to aggravate coeliac disease. However, orally administered enzymes are potentially subject to inactivation in the gastrointestinal tract.

## Inhibitors

Several prolyl endopeptidase inhibitors are known, and have been suggested as possible nootropic and antidepressant drugs. Notable compounds include:
* Pramiracetam
* Baicalin
* JTP-4819
* KYP-2047
* S-17092
* Berberine
# Nicolas Joly

Nicolas Joly (born 1945) is a French winegrower in the Loire wine region, and one of the pioneers and leading personalities of the biodynamic wine movement.

## Early life and education

Joly studied at Columbia University and subsequently worked for J.P. Morgan in New York City as an investment banker. He was later posted to London, but left banking in 1977 to take over his family's wine estate, Château de la Roche aux Moines in Savennières.

## Wine career

At the time he took over the family estate, Joly was sceptical about modern agriculture and the effect it had on nature. He encountered a book on biodynamic farming and took an active interest in the ideas found there, and from 1980 started to experiment with them in his wine estate. From 1981, the estate's top wine Clos de la Coulée de Serrant has been made biodynamically, and from 1984 the estate's entire range has been produced biodynamically. Coulée de Serrant is among the very few single vineyards monopole to be granted its own Appellation d'Origine Contrôlée; others include Romanée-Conti, La Tâche, and Château-Grillet.
Joly has later written extensively on biodynamic wine production, and has served as an inspiration to many other wine producers who have converted to biodynamic practices.
His biodynamic convictions also means that Joly disapproves of the label "winemaker" to the extent that his business card is reported to read "Nicolas Joly, Gérant de la Société, Nature assistant and not a winemaker".

## Château de la Roche aux Moines

Nicolas Joly and his Château de la Roche aux Moines hold all 7 hectares (17 acres) of Savennières most celebrated enclave, Coulée de Serrant, which is an Appellation d'origine contrôlée of its own, Savennières-Coulée-de-Serrant. Joly's wine from this appellation is labelled Clos de la Coulée de Serrant and is often mentioned as one of the world's best dry white wines.
The range of wines consists of:
* Clos de la Coulée de Serrant, from the appellation Savennières-Coulée-de-Serrant
** In some vintages, a moelleux (sweet) version of Clos de la Coulée de Serrant is also produced.
* Clos de la Bergerie, from the appellation Savennières-Roche-aux-Moines
* Les Vieux Clos, from the appellation Savennières. This wine is labelled Les Clos Sacrés when it is exported to the United States.
In recent years, Nicolas Joly's daughter, Virginie Joly, has taken over much of the task of running the estate.

## Books

Nicolas Joly's writings on biodynamic wines consist of books directed at winegrowers and wine consumers, respectively. His book for winegrowers is called Le Vin du ciel à la terre and has been through several editions. In its English adaptation for the North American market, it was given the title Wine From Sky To Earth. His book for wine consumers is called Le Vin, la Vigne et la Biodynamie and was adapted as What is Biodynamic wine ? in its 2007 UK edition and as Biodynamic Wine Demystified in its 2008 US edition. His books have also been published in Czech, German, Hungarian, Italian, Japanese, Portuguese and Spanish.
# Pogonolepis stricta

Pogonolepis stricta is a species of flowering plant in the family Asteraceae. The species is endemic to Western Australia. It was first described by Joachim Steetz in 1845.
It is an annual herb, with yellow flowers (from August to November), growing to heights of 1 cm to 20 cm high on a variety of soils.
# Moose River

Moose River may refer to:

## Rivers
### Canada

* Moose River (British Columbia)
* Moose River (Nova Scotia), site of the Moose River Gold Mines, Nova Scotia
* Moose River (Ontario)
* Moose River (Québec)

### United States

* Moose River (Maine)
* Moose River (Namakan Lake), Minnesota
* Moose River (Nina Moose River), Minnesota
* Moose River (Thief Lake), Minnesota
* Moose River (Willow River), Minnesota
* Moose River (New Hampshire)
* Moose River (New York)
* Moose River (Vermont)
* Moose River (Alaska), tributary of the Kenai River
** Moose River Site, an archeological site at the confluence of the Moose and Kenai rivers

## Places

* Moose River, Maine, United States
* Moose River, Pictou, Nova Scotia in Pictou County
* Moose River, Cumberland, Nova Scotia in Cumberland County
* Moose River Gold Mines, Nova Scotia in the Halifax Regional Municipality
# Hüseynhacılı

Hüseynhacılı (also, Guseyngadzhyly and Gusi-Nadzhaly) is a village and municipality in the Masally Rayon of Azerbaijan. It has a population of 1,040.
# New-Yorker Abend-Zeitung

The New-Yorker Abend-Zeitung was a daily evening German language newspaper in New York City published from 1851 to 1874 that directly competed with the Democratic New Yorker Staats-Zeitung.

## History

Published by revolutionary émigré Forty Eighter Friedrich Rauchfuss, the newspaper was strongly anti-slavery and affiliated with the burgeoning Republican Party. Friedrich Kapp served as the first editor. In 1852, Rauchfuss hired journalist Hermann Raster as editor-in-chief, himself a fellow Forty Eighter from the Duchy of Anhalt who previously served as editor of the abolitionist newspaper the Buffalo Demokrat. In the events leading up to the American Civil War, the paper, which was considered radical at the time, expressed the view that John Brown's raid on Harpers Ferry was a revolutionary act of a European character, which Raster deemed atypical for the United States. During the war, the paper was staunchly pro-Union. In 1867, Raster left his position as editor-in-chief after fifteen years and relocated to Chicago to edit the Illinois Staats-Zeitung.
The separate Sunday edition of the paper was called the Atlantische Blätter.
# Paul Schroder

Paul Schroder (born 1966 or 1967) is a former trade union official, and current chief executive of AustralianSuper, Australia's largest superfund by assets under management.
Paul spent 20 years working in the Australian union movement before joining AustralianSuper. During this time he worked for the Finance Sector Union.
in 2007 he joined AustralianSuper as the fund's general manager of business development. He later was promoted to the role of chief risk officer, prior to his appointment as chief executive of the fund in 2021 as the replacement for Ian Silk.
His appointment to the role of AustralianSuper chief executive in 2021 was controversial. Journalists in The Age criticised the fund's decision to appoint him chief executive to replace Ian Silk instead of pursuing an international search process. Of the appointment, they said it 'did little to rescue the super sector's reputation as a storehouse for former Labor/union types'.
As of 2023 his annual salary remuneration as the fund's chief executive amounted to $1.14m.
He has publicly advocated for social reforms of the superannuation system to reduce gender inequality, including reforms to reduce the gender gap in super balances, such as assistance for unpaid caregiving work.
# Fujifilm X70

The Fujifilm X70 is an APS-C sensor digital compact camera with an 18.5 mm fixed prime lens (28 mm equivalent angle of view (AOV) in 35 mm full frame format). It is part of Fujifilm's X-Series of cameras. It was announced in January 2016 (along with the Fujifilm X-Pro2) and was released on 18 February 2016.

## Comparison with other Fujifilm cameras

Reviewers have noted the X70's similarity to the Fujifilm X100T and to the Ricoh GR II. The X70 combines an X-Trans CMOS II sensor with an EXR processor II, and is the smallest of Fujifilm's cameras to be equipped with the company's APS-C sensor. It shares some technology with the Fujifilm X100T (its sensor and auto focus system) but has a wider angle lens with a slower aperture, is smaller, lacks a built in viewfinder and has a tilting and fully upwards articulating touchscreen display.

## Key features

* 16.3 megapixel, APS-C sized X-Trans CMOS II sensor
* Tilting and fully upwards articulating touchscreen display
* Digital teleconverter – 28 mm / 35 mm / 50mm (equivalent angle of view (AOV) in 35 mm full frame format)
* Full HD video / 1080p / 1920 x 1080 at 60p
* ISO 200–6400, expandable to 100–51200
* 1/4000 s (mechanical shutter); 1 s to 1/32000 s (electronic shutter)

## Accessories

* VF-X21 hot shoe-mountable optical viewfinder
* WCL-X70 Wide Conversion Lens
# Janet L. Dolgin

Janet L. Dolgin is an American legal scholar and Jack and Freda Dicker Distinguished Professor of Health Care Law at Hofstra University.
# Prochoreutis diakonoffi

Prochoreutis diakonoffi is a species of metalmark moth in the family Choreutidae. It is known from Shaanxi, China and from Honshu, Japan.
# Purple City Music Festival

Purple City Music Festival is a multi-day music festival and showcase for all ages, held in various live music venues and other locations in downtown Edmonton, the capital city of the Canadian province of Alberta.

## Festival History

The festival started out -- or grew out of -- the Up + Downtown Music Festival, which ran annually from 2013 to 2019. In 2020, Ryan Rathjen, a radio host on CJSR-FM, became executive director of the festival, and led its rebranding in an attempt to make the festival more inclusive and collaborative.
Purple City 2021 was held outdoors in William Hawrelak Park.
The following year, amid the easing of pandemic restrictions, the festival was held in various locations across the city, including Hawrelak Park and the Garneau Theatre.
Its 2023 edition was held 25-27 August, featuring over 60 acts at eight stages within a two-block radius. The venues included The Starlite Room, the Freemasons Hall of Edmonton, McDougall United Church, and Downtown Edmonton Community League, as well as the Purple City Block Party, an outdoor stage on 102 Street NW which was closed to car traffic for the day.
The headliners included Los Angeles hardcore punk supergroup Off! fronted by Keith Morris of Black Flag/Circle Jerks fame, LA garage rock band Death Valley Girls, Hand Habits, Frankie and the Witch Fingers, Light Asylum, and Austin shoegaze band Ringo Deathstarr.
A highlight of the festival was BatScratch, fronted by a 7-year-old boy. Their presence on the lineup reportedly helped convince Off! to join the festival.
The festival has been praised for taking place in one central area, as well as for allowing underage people to enter all the venues, plus the inclusion of a high number of female-fronted acts.

## Meaning of Name

The name Purple City comes from a ritualistic tradition of the local youth culture. People visit the Alberta Legislature Building at night to stare into the floodlights. After about a minute of exposure, the light makes all the surroundings appear purple.
# AMRL

AMRL may refer to:
* Armored Medical Research Laboratory, U.S. Army
* AASHTO Materials Reference Laboratory, part of the American Association of State Highway and Transportation Officials
* Aeronautical & Maritime Research Laboratory, part of the Australian Defence Science and Technology Group
# Pentagonaster pulchellus

Pentagonaster pulchellus, commonly known as the biscuit star or sometimes the jewelled star, is a species of starfish endemic to New Zealand, where it is common in Cook Strait and around the coasts of the South Island. It has also been recorded from the Chatham Islands and in the Campbell Plateau down to the Snares Islands.

## Description and habitat

The dorsal surface of the biscuit star is studded with hard smooth plates, which enlarge along the margins and at the ends of the five arms into convex, oval-shaped shields. It is one of the most colourful sea stars in NZ, appearing in red, orange, brown, or a silvery purple. The ventral side is a patterned mesh of white over light grey, with yellow tube feet. P. pulchellus frequents seaweed beds, rocky and muddy bottoms from low intertidal down to 300m.
# Hüseynqulular, Tovuz

40°40′N 45°31′E﻿ / ﻿40.667°N 45.517°E﻿ / 40.667; 45.517
Hüseynqulular (also, Guseynkullar) is a village in the Tovuz Rayon of Azerbaijan. The village forms part of the municipality of Göyəbaxan.
# New.Music.Live.

New.Music.Live. (often called NML) is a Canadian television program on MuchMusic that premiered on December 13, 2010, and ended on August 1, 2013. The program succeeded MuchOnDemand as the channel's flagship program. It was broadcast live from MuchMusic's studio at 299 Queen Street West in Toronto.

## Concept

MuchMusic's flagship show delivered the news in music and entertainment, new and popular music videos, live performances, and interviews with artists and celebrities. Viewers in Canada could watch at home and interact with the show via Twitter. Although the show wasn't simulcast, international viewers could watched the show online through their website. Tickets were also available through the website to anyone as long as they can make it to the show.

## VJs

These were the VJs who hosted the program before its cancellation in 2013.
* Lauren Toyota — moved to MTV Canada in 2014, no longer with Bell Media
* Scott Willats — no longer with Bell Media
* Liz Trinnear — currently on etalk
* Phoebe Dykstra — moved to MTV Canada in 2014, left Bell Media
* Chloe Wilde — winner of VJ Search 2013, currently on etalk

### Past hosts

* Jesse Giddings — left MuchMusic for E! News in the United States

## End

On August 1, 2013, it was announced live on-air and on Twitter that a new show would come in September and that New.Music.Live. would be done. However, fans were getting the message that a new show similar to New.Music.Live. would arrive during Fall 2013 based on tweets sent on NML's Twitter feed. All of MuchMusic's in-house shows like Today's Top 10 and Countdown were moved to MTV's new studio in the same building. The former MuchMusic studio space has now been taken over by CTV's The Social and the MuchMusic logo signage outside the building has since been removed.
In 2014, MuchMusic rebranded itself as Much. No new show was ever announced.
# Paul Schuitema

Geert Paul Hendrikus Schuitema (Dutch pronunciation:; 27 February 1897 – 25 October 1973) was a Dutch graphic artist. He also designed furniture and expositions and worked as photographer, film director, and painter, and as a teacher of 'publicity design' at the Royal Academy of Art in The Hague.

## Industrial design

Schuitema studied at the Academie voor Beeldende Kunsten in Rotterdam. In the 1920s, he began to work on graphic design, applying the principles of De Stijl and constructivism to commercial advertising. Along with Gerard Kiljan and his famous colleague Piet Zwart, he followed ideas pioneered in the Soviet Union by El Lissitzky and Rodchenko, in Poland by Henryk Berlewi and in Germany by Kurt Schwitters.
During his employment at the NV Maatschappij Van Berkel Patent scale company in Rotterdam, Schuitema gained recognition for his original designs of stationery and publicity material, often using only the colors black, red and white and bold sans serif fonts. From 1926 on, he started working with photomontages, becoming one of the pioneers of this technique in the field of industrial design. Schuitema was a member of Nederlandsche Vereeniging voor Ambachts- en Nijverheidskunst (V.A.N.K.) the Dutch Association for Craft and Craft Art.
Even though he was a convinced socialist and often designed leftist publications directed at industrial workers, Schuitema also worked for major companies, such as Philips.

## Filmmaking

In the late 1920s, Schuitema became interested in film. Among his first film studies are De Graf Zeppelin in Nederland (1932), and Betogingen (1932). In 1934 he made The Market Halls of Paris, a film in the spirit of the city symphonies, just like his main project, De Maasbruggen, shot in Rotterdam. While Schuitema had started to work on this film in 1932, it was finished in 1937, and only released in 1946, as Les Ponts de la Meuse at the Cannes Film Festival. After World War II, he would make several other films.
During the final years of World War II, Schuitema, along with Jan Bouman, Lou Lichtveld and Eduard Verschueren, began planning for the post-war art community in the Netherlands. In 1944, the four publish a "Report on Stimulation, Development and Organization of the Film Industry in the Netherlands" (Rapport inzake de stimuleering, ontwikkeling en ordening van het Filmwezen in Nederland).
Following Dolle Dinsdag (5 September 1944), he officially joined the resistance forces, assuming a leadership role in the National Film and Photo Reportage Service. After the end of the war, Schuitema and his three partners founded the Dutch Cooperative for Film Production (Nederlandse Werkgemeenschap voor Filmproductie, NWF) in Haarlem and gave the impulse for the formation of the Dutch Film Makers Guild (Beroepsvereniging van Nederlandse Cineasten). In each case, membership was restricted to those artists whose conduct during the occupation was irreproachable.

## Influence

His techniques influenced the Wild Plakken design collective of the late 20th century.
# Anthurium cubense

Anthurium cubense is a species of flowering plant in the family Araceae, native to southeastern Mexico, Central America, Cuba, Colombia, and Venezuela. A large species, it is occasionally kept as a hothouse specimen or as a house plant. With Anthurium pendulifolium, it is a parent of the 'Big Bill' hybrid cultivar, with leaves exceeding 10 ft (3 m).
# Janet L. Smith

Janet Louise Smith (born 1951) is the Margaret J. Hunter Collegiate Professor in the Life Sciences Institute, director of the Center for Structural Biology at the University of Michigan, professor of biological chemistry and biophysics at the University of Michigan, and research professor in the Life Sciences Institute. Additionally, she is the scientific director of The General Medical Sciences and Cancer Institutes’ structural biology facility at the Advanced Photon Source (GM/CA @ APS).

## Biography

Smith is native of Pennsylvania and studied chemistry as a National Merit Scholar at Indiana University of Pennsylvania (BS, 1973). She continued her study at the University of Wisconsin-Madison (Ph.D., 1978) in structure in biology under Dr. M. Sundaralingam supervision. she continued to do her postdoctoral work with Wayne Hendrickson at the Naval Research Laboratory as a National Research Council Research Fellow.

## Research

Smith's research group focus on the understanding of proteins to the molecular level through structural biology. The main experimental technique employed in her lab is X-ray crystallography used to elucidate protein structures. Some of her research findings solved Crystal structures. Janet's lab has also worked towards method development for rapid structure determination. Her lab contributed to the development of multiwavelength anomalous diffraction (MAD) used routinely for structure determination.
Her research group have revealed the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus's reproduction and its interaction with a host's immune system.

## Award and Honors

* Fellow of the American Association for the Advancement of Science (2007)
* National Institutes of Health MERIT award recipient (1998–2008)
* Mildred Cohn Award in Biological Chemistry (2022)
# Nelson Ball (rugby union)

Nelson "Kelly" Ball (11 October 1908 – 9 May 1986) was a New Zealand rugby union player. A wing, Ball represented Wanganui and Wellington at a provincial level, and was a member of the New Zealand national side, the All Blacks, from 1931 to 1936. He played 22 matches for the All Blacks including five internationals.
Ball moved to South Africa in 1948 and lived there for the rest of his life. He was the father of New Zealand cartoonist Murray Ball, and a first cousin of Bill Francis, who played for the All Blacks between 1913 and 1914.
# Nicholas Roy

Nicholas Roy is a Canadian-American computer scientist at the Massachusetts Institute of Technology. He is Professor of Aeronautics and Astronautics at MIT and a principal investigator at the MIT Computer Science and Artificial Intelligence Laboratory, where he leads the Robust Robotics Group.
His research focuses on robotics, machine learning, autonomous systems, planning and reasoning, human-computer interaction and micro air vehicles and also principles of autonomy and decision-making. Alums from his group have gone on to work for and launch major companies that include Zoox and Skydio.
Roy received his PhD under Sebastian Thrun and Tom Mitchell at Carnegie Mellon University in 2003.
# Plenna

Plenna is a village in the administrative district of Gmina Radoszyce, within Końskie County, Świętokrzyskie Voivodeship, in south-central Poland. It lies approximately 3 kilometres (2 mi) north-east of Radoszyce, 16 km (10 mi) south-west of Końskie, and 33 km (21 mi) north-west of the regional capital Kielce.