OpenLLM-France/wikimedia huggingface dataset:
# Reprimo

Reprimo (RPRM), is a gene located at human chromosome 2q23 whose expression in conjunction with p53, along with other genes which are p53-induced, is associated with the arrest of the cell cycle at the G2 phase. Reprimo's protein product is a highly glycosylated polypeptide which, upon its expression, is localized to the cytoplasm where it is primarily active. As the expression of reprimo is controlled by p53, which is in turn controlled by a wide array of convergent signal pathways pertaining to DNA damage or nutrient depravity, its presence is expected within cells which would cause damage should they be freely allowed to replicate. Pursuant to this, reprimo's expression during the G2 phase of the cell cycle ultimately results in the reduction of Cdc2 expression, and in the inhibition of the nuclear translocation of cyclin B1 which is necessary to its function. Reprimo is known to collaborate with p21 to achieve these specific effects, and in a more general sense collaborates with the other p53-induced proteins and effectors to produce the overall cellular response. These regulatory actions help to render the afflicted cell into an arrested state which is less immediately threatening to the whole organism due to the inability of afflicted cells to replicate with damaged DNA, among other potential circumstances, giving the cell an opportunity to undergo DNA repair or apoptosis as the level of damage will dictate. Indefinite cell cycle arrest is another potential outcome. For this reason, it is considered to be a tumor suppressor gene.
Identification of this gene's repression via methylation to its upstream promoter region within various types of cancerous tissue have been used to suggest a connection to the formation of said cancer. These methylation events commonly cause aberrant DNA splicing which may cause one of many potential errors within the resulting mutant reprimo that ultimately undermine its ability to be expressed, have its intended effects, or to accumulate in sufficient quantities to produce the expected arrest reaction. The variability of these outcomes is owed to the large probability space for these point mutations. There is also research to suggest that this gene's expression status within specific tissues may be useful information for the diagnosis or prognosis of certain types of cancer.

## Utility in cancer detection and prognosis

In those whom have already been diagnosed with primary pancreatic cancer, there is a correlative relationship to suggest there will be a much worse prognosis when said tissues were found to contain these methylations to reprimo's promoter.
In terms of early detection, the methylation status of reprimo in esophageal and gastric tissues have had some success in predicting the development of cancer. In the case of gastric cancer, detection methods include sampling of blood plasma.
# Gary Katzmann

Gary Stephen Katzmann (born April 22, 1953) is an American lawyer who has served as a United States judge of the United States Court of International Trade since 2016. He previously served as an associate justice of the Massachusetts Appeals Court from 2004 to 2016.

## Biography

Katzmann received an Artium Baccalaureus degree in 1973 from Columbia College at Columbia University. He received a Master of Letters in 1976 from the University of Oxford. He received a master's in public and private management in 1979 from the Yale School of Organization and Management. He received a Juris Doctor in 1979 from Yale Law School. He began his legal career by serving as a law clerk to Judge Leonard B. Sand of the United States District Court for the Southern District of New York from 1979 to 1980 and to Judge Stephen Breyer of the United States Court of Appeals for the First Circuit from 1980 to 1981. From 1981 to 1983, he worked at Harvard Law School's Center for Criminal Justice as a research associate and special investigator. From 1983 to 2004, he served in the United States Attorney's Office for the District of Massachusetts, including as chief appellate attorney, deputy chief of the criminal division, and chief legal counsel to the United States attorney. While at the United States Attorney's Office, he was detailed to the Federal Bureau of Investigation from 1994 to 1995 and the Office of the Deputy Attorney General from 1993 to 1994. From 2004 to 2016, he served as an associate justice of the Massachusetts Appeals Court adjudicating civil and criminal matters. His twin brother, Robert Katzmann, served as chief judge on the United States Court of Appeals for the Second Circuit.

## Trade Court service

On July 30, 2015, President Barack Obama nominated Katzmann to serve as a United States Judge of the United States Court of International Trade, to the seat vacated by Judge Jane A. Restani, who took senior status on March 1, 2015. He received a hearing on his nomination on January 27, 2016. On April 7, 2016, his nomination was reported out of committee by voice vote. On June 6, 2016, the U.S. Senate confirmed Katzmann's nomination in a voice vote. He received his commission on September 15, 2016.
# George Charles Hurdman

George Charles Hurdman (September 23, 1870 – December 22, 1936) was a Canadian lumber merchant and political figure. He represented Ottawa West in the Legislative Assembly of Ontario from 1914 to 1919 as a Liberal member.
He was born in Ottawa, Ontario, the son of George Hurdman and Agnes Hurdman. He worked for several lumber firms before establishing his own company in 1899. In that same year, he married Katherine Lynton. Hurdman defeated the incumbent James A. Ellis to win a seat in the provincial assembly in 1914. He served in the local militia and was a lieutenant in the Princess Louise Dragoon Guards during World War I. He died in 1936.
# Conley–Maass Building

The Conley–Maass–Downs Building, also called the Maass and McAndrew Company Building, is one of the oldest remaining commercial buildings in Rochester, Minnesota.

## History

Originally built in 1900 by the Rochester Woolen Mill Co to produce pants made from wool fabric from their mill. The woolen mill company went bankrupt in 1903, and the factory was purchased by the Conley Camera Company (established by Kerry Conley and his brother Fred) in 1904.
The Conley company and the building were featured in the 1908 Sears catalog. They remained until 1909 when they moved to a larger facility on the north side of Rochester.
Maass & McAndrew Plumbing and Heating purchased the building in 1910 and occupied it until 1955. Maass & McAndrew did much work for the Mayo Clinic and one of the family members, Frederic Maass, worked with Henry Stanley Plummer in designing the Plummer Building and later became Chief Engineer at Mayo.
It has also housed the Fraternal Order of Eagles, Veterans of Foreign Wars, the Loyal Order of Moose, The Salvation Army, Rochester Ballet School, Masque Theatre, and Words Players.
In 2016, the new owners Hunter and Traci Downs undertook a $2.2 million restoration project. The main level houses a restaurant called Bleu Duck Kitchen and the upper-level houses commercial office space. In 2021, Google announced occupancy within one of the commercial office spaces - marking the first Google location in Minnesota.
# Janmejaya Sinha

Janmejaya Kumar Sinha (born September 12, 1959) is the present chairman of Boston Consulting Group (BCG) India, a BCG fellow and a member of the Henderson Institute Innovation Sounding Board.

## Career

Janmejaya Kumar Sinha is the present chairman of Boston Consulting Group (BCG) India. He is also a member of BCG's Henderson Institute Innovation Sounding Board. He served as Chairman Asia Pacific for BCG from 2009 to 2018. Additionally, he has served on the firms executive committee from 2006 to 2018. He has been with BCG since 1998.
Prior to becoming Chairman Asia Pacific, he was Managing Director of the India Practice from 2003 till 2009. In 2010, Consulting Magazine considered him to be among the 25 most influential consultants in the world. He is co-author of several books including 'Untangling Conflict: An Introspective Guide for Families in Business' and 'Your Strategy Needs A Strategy'.
Sinha is currently Chairman of Confederation of Indian Industry (CII) committee on financial inclusion and digitisation, and member of their national council. He has been a member of several committees set up by Government of India, Reserve Bank of India, Indian Banks Association and Confederation of Indian Industry. He is a regular speaker at the World Economic Forum and also at industry summits of Confederation of Indian Industry, Federation of Indian Chambers of Commerce and Industry, Nasscom, Indian Banks Association. He is a contributor to the press and has written across the Indian Express, The Economic Times, Financial Express, Business Standard, and Mint.
Prior to joining BCG in 1998, he worked with The Reserve Bank of India in Calcutta, Mumbai and Patna.
He also serves on several advisory boards for advising organisations such as Cyril Amarchand Mangaldas and Murugappa Group.

## Education

He has a Ph.D. from Princeton University's Woodrow Wilson School of Public and International Affairs. In 1984, he won the INLAKS scholarship to pursue a B.A. and an M.A. in economics from Clare College, Cambridge University. He also has a B.A. and an M.A. in history from St. Stephen's College Delhi University.

## Awards, honors and publications

* Member of NITI Aayog committee to promote the use of digital payment systems
* Member of Advisory Panel on Institutions and Market Structure for RBI.
* Member of Planning Commission's Panel of Experts on Reforms in Central Public Sector Enterprises
* Awarded INLAKS scholarship to pursue studies in Cambridge University 1984
* Awarded Wilson fellowship in Princeton University 1994
* Awarded Diamond Jubilee fellowship By Indian Institute of Bankers to Study gold market 1990
* Author of 'Own the Future:50 Ways to Win from The Boston Consulting Group'
* Author of 'Your Strategy Needs A Strategy' published by Harvard Business Review Press
* Author of 'Untangling Conflict: An Introspective Guide for Families in Business' published by Penguin Enterprise
# Zapovedny, Kursk Oblast

Zapovedny (Russian: Заповедный) is a rural locality (a settlement) in Novoposelenovsky Selsoviet Rural Settlement, Kursky District, Kursk Oblast, Russia. Population: 98 (2010 Census); 107 (2002 Census);

## Geography

The settlement is located 75 km from the Russia–Ukraine border, 18 km south-west of Kursk, 7 km from the selsoviet center – 1st Tsvetovo.

### Climate

Zapovedny has a warm-summer humid continental climate (Dfb in the Köppen climate classification).

## Transport

Zapovedny is located 0.5 km from the federal route M-2 Crimea Highway (a part of the European route E105), on the road of intermunicipal significance 38H-180 ("Crimea Highway" – Beryozka), 9 km from the nearest railway halt 457 km (railway line Lgov I — Kursk).
The rural locality is situated 25 km from Kursk Vostochny Airport, 107 km from Belgorod International Airport and 219 km from Voronezh Peter the Great Airport.
# Hruševka

Hruševka (pronounced; German: Hruschouka) is a small settlement in the Tuhinj Valley in the Municipality of Kamnik in the Upper Carniola region of Slovenia.
# Volčji Potok

Volčji Potok (pronounced; German: Wolfsbach) is a village on a terrace on the left bank of the Kamnik Bistrica River in the Municipality of Kamnik in the Upper Carniola region of Slovenia.

## History

A cell of the first Communist Party in the Kamnik area was established at the Cerar Inn in 1939. During the Second World War, the Partisans broke into the manor in the village on 14 January 1943 and stole a large quantity of food. After the war, much working-class housing was built in Volčji Potok. A catchment basin for local water supply was built below the village in 1967.

## Castle and manor

The overgrown foundations of Volčji Potok Castle (German: Wolfspuchell) stand east of the village on Wolf Hill (Slovene: Volcji hrib). The castle was first mentioned in written sources in 1220, but was already in ruins by the 17th century. Construction of Volčji Potok Manor (German: Wolfsbüchel)), which stood below the hill, was begun by the Bonhomo family in the 17th century. The manor was purchased in 1882 by Ferdinand Souvan (1840–1915), who remodeled it and planted the meadow in front of it with trees. This park was expanded to 12 hectares by his son Leon Souvan (1877–1949), who planted it with domestic and exotic trees and surrounded it with a hornbeam hedge. The manor was burned by the Partisans on 13 April 1944. After the war, the ruins of the manor were razed and the manor chapel was converted into a restaurant.

## Arboretum

Today, Volčji Potok is best known for its arboretum, the largest and most popular botanical garden in Slovenia. The Volčji Potok Arboretum is open from the beginning of March until the end of November. It was established in 1952 by the University of Ljubljana on what was already a well-established estate with extensive parks around a Baroque mansion that was destroyed in the Second World War.

## Church

The local church is dedicated to Saint Oswald. It features several paintings from Leopold Layer's school. The church was first mentioned in written sources in 1526 and was reworked in the 18th century.

## Notable people

Notable people that were born or lived in Volčji Potok include:
* Rudolf Krivic (1887–1983), journalist
# Group of Democratic Centralism

The Group of Democratic Centralism (Russian: Группа демократического централизма, romanized: Gruppa demokraticheskogo tsentralizma), sometimes called the Group of 15, the Decists, or the Decemists (децисты, detsisti), was a dissenting faction within the Communist Party of the Soviet Union in the early 1920s.

## History

The Group was formed in March 1919 at the 8th Party Congress. It was composed mostly of Bolshevik intellectuals who criticised the leadership of the Communist Party for excessive centralisation of political power in the party, removal of local party initiative, and rigid control from above within the industry, Party and local administration. They believed that the democratic aspect of democratic centralism had been degraded. Opposed to what they viewed as a dictatorship of the Party, the Group advocated a return to dictatorship of the proletariat.
The group's original leaders were Old Bolsheviks Valerian Obolensky-Ossinsky, Vladimir Smirnov, Timofei Sapronov, V. N. Maximovsky, M. S. Boguslavsky, A. Z. Kamensky, Isaak Dashkovsky and Raphail Farbman. Their influence within the Party, always limited, peaked at the 9th Party Congress in March–April 1920 when they were given partial support on some issues by senior Communists like Mikhail Tomsky and Konstantin Yurenev. Nonetheless, their proposals were voted down. They were active during the intra-Party "trade union discussion" in late 1920-early 1921 when the Party split into numerous factions, but didn't gather much support and the faction became moribund after the 10th Party Congress in March 1921.
The Group's leaders continued to protest what they saw as a gradual abolition of intra-Party democracy throughout the early 1920s and joined Leon Trotsky's Left Opposition in 1923. In 1926 Sapronov and Smirnov formed the "Group of 15", which joined the United Opposition headed by Trotsky, Grigory Zinoviev and Lev Kamenev. They were expelled from the Communist Party at the 15th Party Congress in December 1927 along with the rest of the United Opposition. Although some of them repented and were re-admitted to the Party in the early 1930s, they were purged, charged and executed during the Great Purge in the late 1930s.
* Obolensky-Ossinsky attended the World Social Economic Conference organised by the International Industrial Relations Institute held at the Vereeniging Koloniaal Institute, Amsterdam. This was the first occasion that Soviet officials had travelled to the West to discuss how the Five Year Plan worked. He was executed in 1938.
# Kate Peterson

Kate E Peterson (born 3 December 2002) is an Australian cricketer who plays for South Australia in the Women's National Cricket League (WNCL) and Sydney Sixers in the Women's Big Bash League (WBBL). An all-rounder, she bowls right-arm fast-medium and bats right-handed.
Peterson joined Sydney Thunder ahead of the 2019–20 WBBL season, but had to wait until the following season to make her debut against Perth Scorchers on 4 November 2020. She did not bat or bowl in her only match for the season, which the Thunder won by 24 runs. On 18 May 2021, it was announced that she had joined South Australia ahead of the 2021–22 Women's National Cricket League season.
# Charles Newton Little

Charles Newton Little (1858–1923) was an American mathematician and civil engineer. He was known for his expertise in knot theory, including the construction of a table of knots with ten or fewer crossings.
Little's father was a missionary to Madurai, in India, where Little was born in 1858; his family returned with him to America in 1859. He earned an A.B. from the University of Nebraska in 1879, and continued at Nebraska's Institute of Mathematics and Civil Engineering, where he earned an M.A. in 1884. After this, he entered graduate study at Yale University, and completed his Ph.D. in 1885 under the supervision of Hubert Anson Newton, with a dissertation concerning knot theory.
He returned to the University of Nebraska as an associate professor of civil engineering, and was promoted to full professor in 1889. In 1893 he joined Stanford University as a professor of pure mathematics, after turning down a chair of mathematics at Nebraska. In 1899–1900 he went on leave from Stanford, and traveled to Germany to study mathematics with Felix Klein and David Hilbert. He moved again in 1901 to the University of Idaho, as a professor of civil engineering, and in 1911 was appointed as dean of engineering there.
He died on September 7, 1923, of heart failure, in Berkeley, California.
# Moqanak, Qazvin

Moqanak (Persian: مقانك, also Romanized as Moqānak, Moghānak, Mīqānak, Mowkanak, Mukanak, and Muqanak) is a village in Chuqur Rural District, Tarom Sofla District, Qazvin County, Qazvin Province, Iran. At the 2006 census, its population was 57, in 20 families.
# Radical Socialist Party (Luxembourg)

The Radical Socialist Party (Luxembourgish: Radikal-Sozialistesch Partei, French: Parti Radical Socialist) was a progressive Luxembourgian political party that existed from 1925 to 1932. It was the successor of the Liberal League, but, unlike its predecessor, it existed as an organised extra-parliamentary party, marking itself as Luxembourg's first true liberal political party. It was the predecessor of the Radical Liberal Party and, ultimately, of the current Democratic Party.

## History

The party was founded following a split in the Liberal League, which had been riven by ideological splits between the classical liberal 'old liberals' led by the party's founder Robert Brasseur and the progressive 'new liberals' led by the Mayor of Luxembourg City, Gaston Diderich. When the Liberal League collapsed, the progressives reformed under Diderich's leadership as the Radical Socialist Party (the name reflecting its left-wing tendencies compared to its predecessor), whilst the old Liberals formed the Left Liberals.
The party was instantly accepted into a new coalition government, headed by Pierre Prüm of the small populist Independent National Party. The government lasted only one year, before falling apart due to ideological strains between its constituent parties and with the Socialist Party. In 1928, a faction broke away under the leadership of Marcel Cahens as a protest against the party's involvement in the Party of the Right government of Joseph Bech, becoming the Radical Party
However, the parties remained close, and eventually reunited in 1932 as the Radical Liberal Party, which would take part in governments from 1932 until 1938. After the Second World War, the liberal movement would find itself united again with the emergence of the Democratic Party.
# Gatab-e Jonubi Rural District

Gatab-e Jonubi Rural District (Persian: دهستان گتاب جنوبي) is in Gatab District of Babol County, Mazandaran province, Iran. Its capital is the village of Bala Marzbal.

## Demographics
### Population

At the time of the 2006 National Census, the rural district's population was 14,743 in 3,532 households. There were 14,955 inhabitants in 4,387 households at the following census of 2011. The 2016 census measured the population of the rural district as 15,030 in 4,917 households. The most populous of its 20 villages was Ahangar Kola, with 3,500 people.
# You Disappear

You Disappear (Danish: Du forsvinder) is a 2017 Danish drama film directed by Peter Schønau Fog. The film was based on Christian Jungersen's novel by the same name. It was screened in the Special Presentations section at the 2017 Toronto International Film Festival. It was selected as the Danish entry for the Best Foreign Language Film at the 90th Academy Awards, but it was not nominated.
This is Michael Nyqvist‘s last film released 2 months before his death.

## Plot

Frederik is diagnosed with a brain tumor that can cause behaviour disturbances. His wife Mia questions what kind of man he is, especially when it's discovered he is embezzling from the school he headmasters.

## Cast

* Trine Dyrholm as Mia Halling
* Nikolaj Lie Kaas as Frederik Halling
* Michael Nyqvist as Bernard Berman
* Sofus Rønnov as Niklas Halling
* Mikkel Følsgaard as Prosecutor
* Emilie Koppel as Emilie

## Reception

On review aggregator website Rotten Tomatoes, the film has an approval rating of 36% based on 11 reviews, and an average rating of 5.2/10.
# A.D.A.M. The Inside Story

A.D.A.M. The Inside Story is a 1995 scientific educational interactive CD-ROM. It was one in a series of titles made in collaboration between Columbia/HCA Healthcare Corporation and A.D.A.M. Software, alongside titles such as A.D.A.M. Life's Greatest Mysteries and A.D.A.M. Nine Month Miracle.

## Format and interface

Information is organized in the style of a chapter book, with different sections providing information and digital illustrations pertaining to each of various organ systems within the human body. There is an option to block access to the section on the reproductive system and cover the intimate parts of the digital models of Adam and Eve with fig leaves.

## Reception

SuperKids called it an "excellent" piece of human body software. The game won a Codie Consumer Software Award for Best Home Learning Program.
# The Equivalent

The Equivalent was a sum negotiated at £398,085 10s. 0d. (equivalent to £84,606,229 in 2023) paid to Scotland by the English Government under the terms of the Acts of Union 1707. Proposals for it first emerged in the course of abortive Union negotiations in 1702 to 1703.
The Equivalent's purposes were ostensibly to take account of the contribution that Scots taxpayers would then make towards servicing the English national debt and as transitional mitigation of the effects of higher taxes on the Scottish economy. Though attempts have been made to see it as a precise calculation, it is now generally regarded as part of a political bargain designed for other purposes as well, such as the costs of winding up the Company of Scotland which had undertaken the Darien scheme. Shareholders in and creditors of the company were to receive 58.6% of The Equivalent. It was also suggested that payments found their way to members of the Scottish Parliament who voted for its abolition.
The fund was ultimately overseen in 1728 by Patrick Campbell, Lord Monzie, a Scottish judge.