# List of mayors and municipal presidents of San Luis Potosí City

The following is a list of presidents of San Luis Potosí municipality, Mexico.
| Term | Officer | Office | Notes |
| 1592 | Miguel Caldera | Senior judge | |
| 1592 | Juan de Oñate | Mayor | |
| 1593 | Juan de Oñate | Mayor | Until 25 October |
| 1593 | Juan López del Riego | Mayor | Appointed 13 October |
| 1594 | Juan López del Riego | Mayor | |
| 1595 | Juan López del Riego | Mayor | |
| 1596 | Juan López del Riego | Mayor | Ceased at the beginning of the year |
| 1596 | Luis de Valderrama Saavedra | Mayor | |
| 1597 | Luis de Valderrama Saavedra | Mayor | |
| 1598 | Luis de Valderrama Saavedra | Mayor | |
| 1599 | Luis de Valderrama Saavedra | Mayor | |
| 1599 | Leonel de Cervantes | Mayor | At the end of the year |
| 1600 | Leonel Cervantes | Mayor | |
| 1601 | Leonel Cervantes | Mayor | |
| 1602 | Leonel Cervantes | Mayor | |
| 1603 | Joan de Frías Salazar | Mayor | |
| 1604 | Joan de Frías Salazar | Mayor | |
| 1605 | Joan de Frías Salazar | Mayor | Ceased in June |
| 1606 | Juan de Marmolejo | Mayor | |
| 1607 | Juan de Marmolejo | Mayor | Ceased in April |
| 1607 | Alonso de Oñate | Mayor | |
| 1608 | Alonso de Oñate | Mayor | |
| 1609 | Alonso de Oñate | Mayor | |
| 1609 | Francisco Mejía de Carvajal | Mayor | In November |
| 1610 | Francisco Mejía de Carvajal | Mayor | |
| 1611 | Francisco Mejía de Carvajal | Mayor | He ceased in November, and died |
| 1612 | Juan Zaldívar Mendoza | Mayor | |
| 1613 | Juan Zaldívar Mendoza | Mayor | Ceased |
| 1613 | Pedro Salazar | Mayor | He was already in office in August |
| 1614 | Pedro de Salazar | Mayor | |
| 1615 | Pedro Salazar | Mayor | |
| 1616 | Pedro Salazar | Mayor | |
| 1617 | Pedro Salazar | Mayor | |
| 1618 | Pedro Salazar | Mayor | |
| 1619 | Alonso Guajardo Mejía | Mayor | |
| 1620 | Alonso Guajardo Mejía | Mayor | |
| 1621 | Alonso Guajardo Mejía | Mayor | Ceased in the middle of the year |
| 1621 | Alonso Tello Guzmán | Mayor | |
| 1622 | Alonso Tello Guzmán | Mayor | |
| 1623 | Alonso Tello Guzmán | Mayor | He died on 27 January |
| 1623 | Juan Cerezo de Salamanca | Mayor | Since March |
| 1624 | Juan de Cerezo de Salamanca | Mayor | |
| 1625 | Juan de Cerezo de Salamanca | Mayor | |
| 1626 | Juan de Cerezo de Salamanca | Mayor | Ceased in July |
| 1626 | Diego de Astudillo Carrillo | Mayor | At the end of the year; days later he left office |
| 1627 | Martín del Pozo y Aguilar | Mayor | |
| 1628 | Martín del Pozo y Aguilar | Mayor | |
| 1629 | Martín del Pozo y Aguilar | Mayor | |
| 1630 | Martín del Pozo y Aguilar | Mayor | |
| 1631 | Martín del Pozo y Aguilar | Mayor | Ceased in June |
| 1631 | Pedro de Vértiz | Mayor | |
| 1632 | Pedro de Vértiz | Mayor | |
| 1633 | Pedro de Vértiz | Mayor | |
| 1634 | Pedro de Vértiz | Mayor | |
| 1635 | Pedro de Vértiz | Mayor | |
| 1636 | Pedro de Vértiz | Mayor | |
| 1637 | Lope de Mozalve y Almendáriz | Mayor | |
| 1638 | Lope de Mozalve y Almendáriz | Mayor | |
| 1639 | Lope de Mozalve y Almendáriz | Mayor | |
| 1640 | Lope de Mozalve y Almendáriz | Mayor | |
| 1640 | Álvaro Ramírez de Arellano | Mayor | February |
| 1641 | Lope de Mozalve y Almendáriz | Mayor | |
| 1641 | León de Alza | Mayor | Appointed 20 September 1640 |
| 1642 | León de Alza | Mayor | |
| 1643 | León de Alza | Mayor | |
| 1644 | León de Alza | Mayor | |
| 1645 | León de Alza | Mayor | |
| 1646 | León de Alza | Mayor | |
| 1647 | León de Alza | Mayor | Ceased by the end of the year |
| 1647 | Nicolás de Bonilla y Bastida | Mayor | At the end of the year |
| 1648 | Nicolás de Bonilla y Bastida | Mayor | |
| 1649 | Nicolás de Bonilla y Bastida | Mayor | |
| 1650 | Nicolás de Bonilla y Bastida | Mayor | Ceased in March |
| 1650 | Alonso de Guzmán | Mayor | |
| 1651 | Alonso de Guzmán | Mayor | |
| 1652 | Alonso de Guzmán | Mayor | Ceased |
| 1652 | Diego de Ulloa Pereira | Mayor | Since March |
| 1653 | Diego de Ulloa Pereira | Mayor | Ceased in November |
| 1653 | Juan Antonio de Irurzun | Mayor | |
| 1654 | Juan Antonio de Irurzun | Mayor | Took office in July |
| 1655 | Juan Antonio de Irurzun | Mayor | |
| 1656 | Juan Antonio de Irurzun | Mayor | September |
| 1657 | Juan Antonio de Irurzun | Mayor | |
| 1658 | Bernardo Pérez de Azpilicueta | Mayor | |
| 1659 | Bernardo Pérez de Azpilicueta | Mayor | He ceased on 21 April, but continued until January 1660 |
| (1659) | Tristán Luna y Arellano | Mayor | Appointed by real provision on 9 May |
| 1660 | Bernardo Pérez de Azpilicueta | Mayor | |
| 1660 | Tristán Luna y Arellano | Mayor | |
| 1661 | Tristán Luna y Arellano | Mayor | Ceased |
| 1661 | Juan Ruiz de Zavala y Lois | Mayor | March |
| 1661 | Fernando de Torres y Ávila | Mayor | June |
| 1662 | Fernando de Torres y Ávila | Mayor | |
| 1663 | Fernando de Torres y Ávila | Mayor | |
| 1664 | Fernando de Torres y Ávila | Mayor | |
| 1664 | Pedro Sáenz Izquierdo | Mayor | Appointed on 11 November |
| 1665 | Pedro Sáenz Izquierdo | Mayor | |
| 1666 | Pedro Sáenz Izquierdo | Mayor | |
| 1666 | Bartolomé de Estrada y Valdés | Mayor | Appointed on 17 December |
| 1666 | Diego de Valdés | Mayor | Appointed on 20 December |
| 1667 | Bartolomé de Estrada y Valdés | Mayor | |
| 1668 | Bartolomé de Estrada y Valdés | Mayor | Ceased in December |
| 1668 | Alfonso Flores y Valdés | Mayor | Appointed on 14 October |
| 1669 | Alfonso Flores y Valdés | Mayor | |
| 1670 | Alfonso Flores y Valdés | Mayor | Ceased |
| 1670 | Juan Ruiz de Zavala y Lois | Mayor | Appointed on 16 November |
| 1671 | Juan Ruiz de Zavala y Lois | Mayor | |
| 1672 | Juan Ruiz de Zavala y Lois | Mayor | |
| 1673 | Juan Ruiz de Zavala y Lois | Mayor | |
| 1674 | Feliciano Hurtado de Amézaga Salazar | Mayor | January to June |
| 1674 | Martín de Mendalde | Mayor | Appointed on 8 February; arrived in July |
| 1675 | Martín de Mendalde | Mayor | |
| 1676 | Martín de Mendalde | Mayor | |
| 1677 | Martín de Mendalde | Mayor | |
| 1677 | Francisco de Gatica | Mayor | |
| 1677 | Pedro de Ullate Ordóñez | Mayor | December |
| 1678 | Pedro de Ullate Ordóñez | Mayor | |
| 1679 | Pedro de Ullate Ordóñez | Mayor | |
| 1680 | Pedro de Ullate Ordóñez | Mayor | |
| 1680 | Luis Francisco de Ullate y Escobedo | Mayor | June to December |
| 1680 | Juan de Camacho Xayna | Mayor | 1 December |
| 1681 | Juan de Camacho Xayna | Mayor | |
| 1682 | Juan de Camacho Xayna | Mayor | |
| 1683 | Juan de Camacho Xayna | Mayor | |
| 1684 | Juan de Camacho Xayna | Mayor | |
| 1685 | Juan de Camacho Xayna | Mayor | Until mid June |
| 1685 | Juan Bautista Ansaldo de Peralta | Mayor | |
| 1686 | Juan Bautista Ansaldo de Peralta | Mayor | |
| 1687 | Juan Bautista Ansaldo de Peralta | Mayor | |
| 1687 | Bernardo de Iñiguez de Vayo | Mayor | Late July |
| 1688 | Bernardo de Iñiguez de Vayo | Mayor | |
| 1689 | Bernardo de Iñiguez de Vayo | Mayor | |
| 1690 | Bernardo de Iñiguez de Vayo | Mayor | |
| 1690 | Alonso Muñoz de Castiblanque | Mayor | In June |
| 1691 | Alonso Muñoz de Castiblanque | Mayor | |
| 1692 | Alonso Muñoz de Castiblanque | Mayor | Ceased |
| 1692 | Domingo Terán de los Ríos | Mayor | 25 August |
| 1693 | Domingo Terán de los Ríos | Mayor | |
| 1693 | Pascual Álvarez Serrano | Mayor | February |
| 1694 | Domingo Terán de los Ríos | Mayor | Ceased |
| 1694 | Francisco Eusebio del Castillo y Saavedra | Mayor | Entered around the month of March |
| 1695 | Francisco Eusebio del Castillo y Saavedra | Mayor | |
| 1696 | Francisco Eusebio del Castillo y Saavedra | Mayor | |
| 1697 | Francisco Eusebio del Castillo y Saavedra | Mayor | |
| 1698 | Francisco Eusebio del Castillo y Saavedra | Mayor | |
| 1698 | Antonio Fernández del Rivero | Mayor | |
| 1699 | Antonio Fernández del Rivero | Mayor | |
| 1700 | Antonio Fernández del Rivero | Mayor | |
| 1701 | Antonio Fernández del Rivero | Mayor | |
| 1701 | Juan Orejón de la Lama y Medrano | Mayor | |
| 1702 | Juan Orejón de la Lama y Medrano | Mayor | |
| 1703 | Juan Orejón de la Lama y Medrano | Mayor | |
| 1704 | Juan Orejón de la Lama y Medrano | Mayor | |
| 1705 | Juan Orejón de la Lama y Medrano | Mayor | |
| 1706 | Manuel Diez Llanos | Mayor | |
| 1706 | Andrés Álvarez Maldonado | Mayor | |
| 1707 | Andrés Álvarez Maldonado | Mayor | |
| 1708 | Andrés Álvarez Maldonado | Mayor | |
| 1709 | Andrés Álvarez Maldonado | Mayor | Ceased on 23 February |
| 1709 | Coronel Sebastián de Oloris | Mayor | |
| 1710 | Coronel Sebastián de Oloris | Mayor | |
| 1711 | Coronel Sebastián de Oloris | Mayor | |
| 1712 | Coronel Sebastián de Oloris | Mayor | |
| 1713 | Coronel Sebastián de Oloris | Mayor | |
| 1714 | Francisco José Vélez Escalante | Mayor | |
| 1715 | Francisco José Vélez Escalante | Mayor | |
| 1716 | Francisco José Vélez Escalante | Mayor | |
| 1716 | Ventura de Zavala y Balanza | Mayor | |
| 1717 | Ventura de Zavala y Balanza | Mayor | |
| 1718 | Leonardo de la Mora y Torres | Mayor | |
| 1719 | Leonardo de la Mora y Torres | Mayor | |
| 1719 | Juan Ángel Roldán | Mayor | |
| 1720 | Leonardo de la Mora y Torres | Mayor | |
| 1721 | Leonardo de la Mora y Torres | Mayor | |
| 1719 | Juan Leandro Pérez Serrano | Mayor | 30 May |
| 1722 | Juan Leandro Pérez Serrano | Mayor | |
| 1723 | Juan Leandro Pérez Serrano | Mayor | |
| 1723 | Antonio Ruiz de Huidobro y Sarabia | Mayor | 13 October 1722 |
| 1724 | Antonio Ruiz de Huidobro y Sarabia | Mayor | |
| 1725 | Antonio Ruiz de Huidobro y Sarabia | Mayor | |
| 1726 | Antonio Ruiz de Huidobro y Sarabia | Mayor | |
| 1727 | Antonio Ruiz de Huidobro y Sarabia | Mayor | |
| 1728 | Antonio Ruiz de Huidobro y Sarabia | Mayor | |
| 1729 | Antonio Ruiz de Huidobro y Sarabia | Mayor | Passed away |
| 1729 | Fernando Manuel Monroy y Carrillo | Mayor | 17 March |
| 1730 | Fernando Manuel Monroy y Carrillo | Mayor | |
| 1731 | Fernando Manuel Monroy y Carrillo | Mayor | Ceased in June |
| 1731 | Victoriano de Oliván | Mayor | |
| 1732 | Victoriano de Oliván | Mayor | |
| 1733 | Victoriano de Oliván | Mayor | |
| 1734 | Victoriano de Oliván | Mayor | |
| 1734 | Antonio Francisco de Medina y Calderón | Mayor | September |
| 1735 | Antonio Francisco de Medina y Calderón | Mayor | |
| 1736 | Victoriano de Oliván | Mayor | |
| 1737 | Victoriano de Oliván | Mayor | |
| 1738 | Victoriano de Oliván | Mayor | |
| 1739 | Victoriano de Oliván | Mayor | |
| 1740 | Victoriano de Oliván | Mayor | |
| 1740 | Luis Vélez de las Cuevas Cabeza de Vaca | Mayor | December |
| 1741 | Luis Vélez de las Cuevas Cabeza de Vaca | Mayor | |
| 1742 | Miguel Yánez | Mayor | 26 January |
| 1743 | Miguel Yánez | Mayor | |
| 1744 | Miguel Yánez | Mayor | |
| 1745 | Miguel Yánez | Mayor | |
| 1745 | Julián de Corzánigo | Mayor | April |
| 1746 | Julián de Corzánigo | Mayor | |
| 1747 | Julián de Corzánigo | Mayor | |
| 1748 | Juan Coutiño de los Ríos | Mayor | August |
| 1749 | Juan Coutiño de los Ríos | Mayor | |
| 1749 | Luis Lasso de la Vega y Ponce de León | Mayor | |
| 1750 | Luis Lasso de la Vega y Ponce de León | Mayor | |
| 1751 | Luis Lasso de la Vega y Ponce de León | Mayor | |
| 1752 | Luis Lasso de la Vega y Ponce de León | Mayor | |
| 1753 | Luis Lasso de la Vega y Ponce de León | Mayor | |
| 1753 | Joseph Xavier Gatuno y Lemos | Mayor | |
| 1754 | Joseph Xavier Gatuno y Lemos | Mayor | |
| 1755 | Joseph Xavier Gatuno y Lemos | Mayor | |
| 1756 | Joseph Xavier Gatuno y Lemos | Mayor | |
| 1757 | Joseph Xavier Gatuno y Lemos | Mayor | |
| 1758 | Joseph Xavier Gatuno y Lemos | Mayor | |
| 1759 | Joseph Xavier Gatuno y Lemos | Mayor | |
| 1759 | Tomás de Costa y Uribe | Mayor | |
| 1760 | Tomás de Costa y Uribe | Mayor | |
| 1761 | Tomás de Costa y Uribe | Mayor | |
| 1762 | Tomás de Costa y Uribe | Mayor | |
| 1763 | Tomás de Costa y Uribe | Mayor | |
| 1764 | Tomás de Costa y Uribe | Mayor | |
| 1765 | Tomás de Costa y Uribe | Mayor | Ceased on 27 January |
| 1765 | Andrés de Urbina Gaviria y Eguíluz | Mayor | |
| 1766 | Andrés de Urbina Gaviria y Eguíluz | Mayor | |
| 1767 | Andrés de Urbina Gaviria y Eguíluz | Mayor | |
| 1768 | Andrés de Urbina Gaviria y Eguíluz | Mayor | |
| 1769 | Andrés de Urbina Gaviria y Eguíluz | Mayor | |
| 1770 | Andrés de Urbina Gaviria y Eguíluz | Mayor | Ceased on 2 September |
| 1771 | Fernando Rubín de Celis Pariente y Noriega | Mayor | |
| 1772 | Fernando Rubín de Celis Pariente y Noriega | Mayor | |
| 1773 | Fernando Rubín de Celis Pariente y Noriega | Mayor | |
| 1774 | Antonio Joaquín de Llano y Villaurrutia | Mayor | |
| 1775 | Antonio Joaquín de Llano y Villaurrutia | Mayor | |
| 1776 | Antonio Joaquín de Llano y Villaurrutia | Mayor | Ceased in July |
| 1776 | Jacinto Pérez de arroyo | Mayor | |
| 1777 | Jacinto Pérez de arroyo | Mayor | |
| 1778 | Jacinto Pérez de arroyo | Mayor | |
| 1779 | Jacinto Pérez de arroyo | Mayor | Died on 29 December |
| 1779 | Manuel Días Fernández | Mayor | 29 December |
| 1780 | Manuel Días Fernández | Mayor | |
| 1781 | Manuel Días Fernández | Mayor | |
| 1782 | Manuel Días Fernández | Mayor | Ceased in March |
| 1782 | Juan Antonio Flores | Mayor | |
| 1782 | Joseph de Castillo y Loaeza | Mayor | |
| 1783 | Joseph de Castillo y Loaeza | Mayor | |
| 1784 | Joseph de Castillo y Loaeza | Mayor | |
| 1785 | Joseph de Castillo y Loaeza | Mayor | |
| 1786 | Joseph de Castillo y Loaeza | Mayor | |
| 1787 | Joseph de Castillo y Loaeza | Mayor | Ceased |
| 1787 | Bruno Díaz de Salcedo | Intendant | 25 October |
| 1788 | Bruno Díaz de Salcedo | Intendant | |
| 1789 | Bruno Díaz de Salcedo | Intendant | |
| 1790 | Bruno Díaz de Salcedo | Intendant | |
| 1791 | Bruno Díaz de Salcedo | Intendant | |
| 1792 | Bruno Díaz de Salcedo | Intendant | |
| 1793 | Bruno Díaz de Salcedo | Intendant | |
| 1794 | Bruno Díaz de Salcedo | Intendant | |
| 1795 | Bruno Díaz de Salcedo | Intendant | |
| 1796 | Bruno Díaz de Salcedo | Intendant | |
| 1797 | Bruno Díaz de Salcedo | Intendant | |
| 1798 | Bruno Díaz de Salcedo | Intendant | |
| 1799 | Bruno Díaz de Salcedo | Intendant | Died on 2 November |
| 1799 | Vicente Bernabéu | Acting intendant | |
| 1800 | Vicente Bernabéu | Acting intendant | |
| 1800 | Cristóbal de Corbalán | Acting intendant | |
| 1801 | Cristóbal de Corbalán | Acting intendant | |
| 1801 | Onésimo Antonio Durán | Intendant | |
| 1802 | Onésimo Antonio Durán | Intendant | |
| 1803 | Onésimo Antonio Durán | Intendant | Ceased on 22 November |
| 1803 | Manuel Ampudia | Intendant | |
| 1804 | Manuel Ampudia | Intendant | Left on 30 November |
| 1805 | Joseph Ignacio Vélez | Acting intendant | Ceased in February |
| 1805 | Joseph Manuel Ruiz de Aguirre | Acting intendant | |
| 1806 | Joseph Manuel Ruiz de Aguirre | Acting intendant | |
| 1807 | Joseph Manuel Ruiz de Aguirre | Acting intendant | |
| 1808 | Joseph Manuel Ruiz de Aguirre | Acting intendant | |
| 1809 | Joseph Manuel Ruiz de Aguirre | Acting intendant | |
| 1810 | Joseph Manuel Ruiz de Aguirre | Acting intendant | |
| 1810 | Manuel Jacinto de Acevedo | Intendant | |
| 1811 | Manuel Jacinto de Acevedo | Intendant | |
| 1812 | Manuel Jacinto de Acevedo | Intendant | |
| 1813 | Manuel Jacinto de Acevedo | Intendant and corregidor | |
| 1813 | Manuel Jacinto de Acevedo | Intendant and political chief | 4 July |
| 1814 | Manuel Jacinto de Acevedo | Intendant | |
| 1815 | Manuel Jacinto de Acevedo | Intendant | |
| 1816 | Manuel Jacinto de Acevedo | Intendant | |
| 1817 | Manuel Jacinto de Acevedo | Intendant | |
| 1818 | Manuel Jacinto de Acevedo | Intendant | |
| 1819 | Manuel Jacinto de Acevedo | Intendant | |
| 1820 | Manuel Jacinto de Acevedo | Intendant | |
| 1821 | Manuel Jacinto de Acevedo | Intendant and political chief | |
| 1821 | Manuel Jacinto de Acevedo | Intendant and chief of the Army | |
| 1822 | Manuel Jacinto de Acevedo | Intendant | He retired on 20 March |
| 1823 | José Ildefonso Díaz de León | Political chief | |
| 1824 | José Ildefonso Díaz de León | Acting governor | |
| 1825 | Pantaleón de Ipiña | Mayor | |
| 1826 | Eulogio Esnaurrízar | Mayor | |
| 1827 | Ignacio de Aztegui | Prefect | |
| 1828 | Ignacio de Aztegui | Prefect | |
| 1829 | Ignacio de Aztegui | Prefect | Resigned |
| 1829 | José Gregorio Sousa | Prefect | Since 1 February |
| 1830 | Jesús Valdés | Prefect | Ceased |
| 1830 | Manuel Othón | Prefect | |
| 1830 | Teniente Coronel Manuel Sánchez | Prefect | 21 July |
| 1831 | Andrés de la Gándara | Mayor | |
| 1832 | Andrés de la Gándara | Mayor | |
| 1833 | José Vicente Liñán | Prefect | |
| 1834 | Pedro Hernández | Prefect | |
| 1835 | Andrés de la Gándara | Prefect | |
| 1836 | Andrés de la Gándara | Mayor | |
| 1837 | Francisco de P. Cabrera y Alderete | Prefect | |
| 1838 | José María Otaegui | Mayor | |
| 1839 | Francisco de P. Cabrera y Alderete | Prefect | |
| 1840 | José María Faz y Cardona | Prefect | |
| 1841 | José Mateo Terán | Prefect | |
| 1842 | José Mateo Terán | Prefect | |
| 1843 | José Eulogio Esnaurrízar | Prefect | Resigned in May |
| 1844 | Pablo de la Barrera | Prefect | |
| 1845 | Francisco Escalante | Prefect | |
| 1845 | Luzardo Lechón | Prefect | |
| 1846 | Juan Nepomuceno González | Prefect | |
| 1847 | Francisco Fregoso | Prefect | |
| 1848 | Mariano Martínez | Prefect | |
| 1849 | Silvestre López Portillo | Prefect | |
| 1850 | Silvestre López Portillo | Prefect | |
| 1851 | Silvestre López Portillo | Prefect | |
| 1851 | José Álvarez y Sagástegui | Prefect | |
| 1852 | Nicolás Mascorro | Prefect | |
| 1853 | José Álvarez y Sagastegui | Prefect | |
| 1853 | Nicolás Mascorro | Acting prefect |
| 1853 | Eulalio Degollado | Prefect | |
| 1854 | General Pánfilo Barasroda | Prefect | |
| 1855 | General Pánfilo Barasroda | Prefect | |
| 1855 | Eulalio Degollado | Prefect | |
| 1855 | Manuel Vejo | President of the City Council | |
| 1855 | Camilo Bros | Prefect | |
| 1855 | Juan Othón | Prefect | |
| 1855 | Nicolás Mascorro | Mayor | |
| 1856 | Carlos María Escobar | Prefect | |
| 1857 | José María Aranda | Prefect | |
| 1857 | Francisco López de Nava | Acting prefect | |
| 1858 | Mariano Gordoa | Prefect | |
| 1858 | Nicolás Mascorro | Prefect | |
| 1859 | Pedro Diez Gutiérrez | Prefect | |
| 1859 | Ramón Calvillo | Mayor | |
| 1860 | Juan Othón | Prefect | |
| 1860 | Ambrosio Espinoza | Prefect | |
| 1861 | ?? | Prefect | |
| 1862 | ?? | Prefect | |
| 1863 | José Castillo | Acting prefect | |
| 1864 | José Castillo | Acting prefect | |
| 1864 | Nicolás Mascorro | Municipal prefect | Until August |
| 1864 | Pedro Diez Gutiérrez | Municipal prefect | |
| 1865 | Pedro Diez Gutiérrez | Municipal prefect | Ceased in June |
| 1865 | Nicolás Mascorro | Municipal prefect | Ceased in November |
| 1865 | Francisco Estrada | Municipal prefect | |
| 1866 | Francisco Estrada | Prefect municipal mayor | |
| 1866 | Octaviano Cabrera Lacavex | Prefec municipal mayor | 16 March |
| 1866 | Juan Othón | Prefect municipal mayor | 27 October |
| 1866 | Isidro Bustamante | Acting political chief | |
| 1867 | Toribio Saldaña | Political chief | |
| 1867 | Hilario Delgado | Political chief | |
| 1868 | José Trinidad Domínguez | Political chief | |
| 1869 | Rafael Montante | Political chief | |
| 1870 | Francisco de P. Palomo | Political chief | |
| 1871 | Lino Maldonado | Acting political chief | In May |
| 1871 | Florencio Cabrera Lacavex | President of the City Council | |
| 1872 | Manuel Muro | Political chief | |
| 1872 | Lino Maldonado | Political chief | |
| 1873 | Tomás Ortiz de Parada | President of the City Council | |
| 1874 | José Encarnación Ipiña | Political chief president | |
| 1875 | Agustín Álvarez | Proprietary political chief | |
| 1876 | Agustín Álvarez | Proprietary political chief | |
| 1877 | Antonio Espinoza y Cervantes | Proprietary political chief | |
| 1877 | Manuel Muro | Proprietary political chief | 22 June |
| 1878 | Mónico Rubalcaba | Proprietary political chief | |
| 1879 | Nabor Macías | Proprietary political chief | |
| 1880 | Francisco Limón | Proprietary political chief | |
| 1881 | Indalecio Rodríguez | Proprietary political chief | |
| 1882 | Ladislao Tovar | Proprietary political chief | |
| 1883 | Matías Hernández Soberón | Proprietary political chief | |
| 1884 | Antonio Montero | Proprietary political chief | |
| 1885 | Macedonio Gómez | Proprietary political chief | |
| 1886 | Antonio Espinoza y Cervantes | Proprietary political chief | |
| 1887 | Antonio Espinoza y Cervantes | Proprietary political chief | |
| 1888 | Antonio Espinoza y Cervantes | Proprietary political chief | |
| 1889 | Antonio Espinoza y Cervantes | Proprietary political chief | |
| 1890 | Antonio Espinoza y Cervantes | Proprietary political chief | |
| 1891 | Francisco Bustamante | Proprietary political chief | |
| 1892 | Francisco Bustamante | Proprietary political chief | |
| 1893 | Francisco Bustamante | Proprietary political chief | |
| 1894 | Francisco Bustamante | Proprietary political chief | |
| 1895 | Francisco Bustamante | Proprietary political chief | |
| 1896 | Francisco Bustamante | Proprietary political chief | |
| 1897 | Blas Escontría Bustamante | Proprietary political chief | |
| 1898 | Blas Escontría Bustamante | Proprietary political chief | |
| 1899 | Pedro Barrenechea | Proprietary political chief | |
| 1900 | Pedro Barrenechea | Proprietary political chief | |
| Term | Municipal president | Political party | Notes |
| 1901–1916 | NA | | |
| 1917 | Severino Martínez Gómez | | |
| 1919 | Refugio T. Yáñez | | |
| 1921 | Antonio Humara Acebo | | |
| 1922 | Pedro Hernández | | |
| 1923 | Pedro Hernández | | |
| 1925 | Pedro Hernández | | President of the Municipal Council |
| 1926 | Eugenio B. Jiménez | | |
| 1928–1929 | Marcelino Zúñiga | | |
| 1931 | Efrén González | PNR | |
| 1932 | Rutilio Alamilla | PNR | |
| 1933 | Vicente Segura | PNR | |
| 1934–1935 | Hipólito Cedillo | PNR | |
| 1936–1937 | José García Zamora | PNR | |
| 1938 | Ernesto Higuera | PNR | |
| 1938 | Alberto Z. Araujo | | President of the Municipal Council |
| 1939–1940 | Manuel Parra López | PRM | |
| 1940–1941 | José L. Cerda | PRM | |
| 1941–1943 | Alfonso Viramontes | PRM | President of the Municipal Council |
| 1943–1946 | Ignacio Gómez del Campo | PRM | |
| 1946 | Antonio Garfias | PRI | Acting municipal president |
| 1946–1949 | Arturo Medina | PRI | |
| 1949–1952 | Agustín Olivo Monsiváis | PRI | |
| 1952 | Antonio Hernández Guerra | PRI | Acting municipal president |
| 1952–1955 | Nicólas Pérez Cerrillo | PRI | |
| 1955 | Socorro Blanc Ruiz | PRI | Acting municipal president |
| 1955–1958 | Alfonso Viramontes, Jr. | PRI | |
| 1959–1960 | Salvador Nava Martínez | Independent | |
| 1960 | Antonio Benavente Zarzosa | | Acting municipal president |
| 1961 | Leonardo Hopper | | President of the Municipal Council |
| 1961–1964 | Javier Silva Staines | PRI | |
| 1964–1967 | Manuel Hernández Muro | PRI | |
| 1967–1970 | Guillermo Fonseca Álvarez | PRI | |
| 1970 | Gabriel Echenique Portillo | PRI | Acting municipal president |
| 1970–1973 | Antonio Acebo Delgado | PRI | |
| 1973–1976 | Félix Dahuajare Torres | PRI | |
| 1976–1979 | Juan Antonio Ledezma Zavala | PRI | |
| 1979–1982 | Miguel Valladares García | PRI | |
| 1982–1984 | Salvador Nava Martínez | Frente Cívico Potosino (FCP) PAN PDM | |
| 1984–1985 | María Guadalupe Rodríguez Cabrera | Frente Cívico Potosino (FCP) PAN PDM | Acting municipal president |
| 1985–1988 | Guillermo Medina de los Santos | PRI | |
| 1988–1991 | Guillermo Pizzutto Zamanillo | Frente Cívico Potosino (FCP) PAN | |
| 1991–1994 | Mario Leal Campos | PAN | |
| 1994 | Rafael del Blanco Garrido | PRI | President of the Municipal Council |
| 1995–1997 | Luis García Julián | PRI | |
| 1997–2000 | Alejandro Zapata Perogordo | PAN | |
| 2000 | Gloria Rosillo Izquierdo | PAN | Acting municipal president |
| 2000–2002 | Marcelo de los Santos | PAN | |
| 2002–2003 | Homero González Reyes | PAN | Acting municipal president |
| 2003 | Jacobo Payán Latuff | | President of the Municipal Council |
| 2003–2006 | Octavio Pedroza Gaitán | PAN | |
| 2006–2009 | Jorge Lozano Armengol | PAN | |
| 2009–2012 | Victoria Labastida Aguirre | PRI PVEM PSD | |
| 2012 | Emigdio Ilizaliturri Guzmán | PRI PVEM PSD | Acting municipal president |
| 2012 | Luis Miguel Ávalos Oyervides | PRI PVEM PSD | Acting municipal president |
| 2012 | Victoria Labastida Aguirre | PRI PVEM PSD | Resumed |
| 2012–2015 | Mario García Valdez | PRI PVEM | Coalition "Compromise for San Luis" |
| 2015–2018 | Ricardo Gallardo Juárez | PRD PT | |
| 2018 | Juan Carlos Torres Cedillo | PRD PT | Acting municipal president |
| 2018 | Ricardo Gallardo Juárez | PRD PT | Resumed |
| 2018–14/11/2020 | Xavier Nava Palacios | PAN | Applied for a temporary leave to run for reelection |
| 15/11/2020–06/06/2021 | Alfredo Lujambio Cataño | PAN | Acting municipal president |
| 07/06/2021–30/09/2021 | Xavier Nava Palacios | Morena | |
| 01/10/2021–18/04/2024 | Enrique Francisco Galindo Ceballos | PRI PAN PRD PCP | Applied for a leave in order to run for reelection, which won |
| 19/04/2024–30/06/2024 | Alexandra Daniela Cid González | PAN | Acting municipal president |
| 01/07/2024–30/09/2024 | Enrique Francisco Galindo Ceballos | PRI PAN PRD PCP | Resumed |
| 01/10/2024– | Enrique Francisco Galindo Ceballos | PAN PRI PRD | Was reelected on 02/06/2024 |