# 2021–22 Southern Miss Lady Eagles basketball team

The 2021–22 Southern Miss Lady Eagles basketball team represented the University of Southern Mississippi during the 2021–22 NCAA Division I women's basketball season. The team was led by 18th-year head coach Joye Lee-McNelis, and played their home games at the Reed Green Coliseum in Hattiesburg, Mississippi as a member of Conference USA (C-USA).
On March 31, 2022, Southern Miss announced that this will be the last season for the team in the C-USA and will join the Sun Belt Conference on July 1, 2022.

## Schedule and results

| Date time, TV | Rank$^#$ | Opponent$^#$ | Result | Record | Site (attendance) city, state |
| Exhibition ||||||
| November 1, 2021* 6:00 p.m. | | Southeastern Baptist | W 109–18 | | Reed Green Coliseum (350) Hattiesburg, MS |
| Non-conference regular season ||||||
| November 9, 2021* 11:00 a.m. | | William Carey | W 72–42 | 1–0 | Reed Green Coliseum (2,388) Hattiesburg, MS |
| November 13, 2021* 2:00 p.m. | | Louisiana–Monroe | W 77–60 | 2–0 | Reed Green Coliseum (1,607) Hattiesburg, MS |
| November 17, 2021* 6:00 p.m., SECN+ | | at Alabama | L 54–86 | 2–1 | Coleman Coliseum (1,784) Tuscaloosa, AL |
| November 20, 2021* 2:00 p.m. | | Samford | W 71–66 | 3–1 | Reed Green Coliseum (1,555) Hattiesburg, MS |
| November 26, 2021* 1:00 p.m. | | Arkansas–Pine Bluff Lady Eagle Thanksgiving Classic | L 57–76 | 3–2 | Reed Green Coliseum (1,410) Hattiesburg, MS |
| November 27, 2021* 11:00 a.m. | | Mississippi Valley State Lady Eagle Thanksgiving Classic | W 72–53 | 4–2 | Reed Green Coliseum (1,425) Hattiesburg, MS |
| December 1, 2021* 4:30 p.m. | | at Georgia State | W 64–56 | 5–2 | GSU Sports Arena (427) Atlanta, GA |
| December 5, 2021* 3:00 p.m. | | at South Alabama | W 71–51 | 6–2 | Mitchell Center (313) Mobile, AL |
| December 13, 2021* 6:00 p.m. | | Blue Mountain | W 75–50 | 7–2 | Reed Green Coliseum (1,324) Hattiesburg, MS |
| December 19, 2021* 1:30 p.m. | | vs. Alabama A&M FAU Holiday Classic | W 70–55 | 8–2 | FAU Arena (477) Boca Raton, FL |
| December 20, 2021* 11:00 a.m. | | vs. Richmond FAU Holiday Classic | L 75–87 | 8–3 | FAU Arena (360) Boca Raton, FL |
| C-USA regular season ||||||
| December 30, 2021 6:30 p.m. | | at Western Kentucky | L 88–98 | 8–4 (0–1) | E. A. Diddle Arena (1,222) Bowling Green, KY |
| January 1, 2022 12:00 p.m. | | at Marshall | L 55–72 | 8–5 (0–2) | Cam Henderson Center (461) Huntington, WV |
| January 9, 2022 2:00 p.m. | | at Louisiana Tech | W 65–59 | 9–5 (1–2) | Thomas Assembly Center (1,632) Ruston, LA |
| January 13, 2022 6:00 p.m. | | Louisiana Tech | W 65–60 | 10–5 (2–2) | Reed Green Coliseum (1,329) Hattiesburg, MS |
| January 17, 2022 1:00 p.m., ESPN+ | | UTEP | W 55–49 | 11–5 (3–2) | Reed Green Coliseum (1,422) Hattiesburg, MS |
| January 22, 2022 2:00 p.m. | | Middle Tennessee | L 71–81 | 11–6 (3–3) | Reed Green Coliseum (1,611) Hattiesburg, MS |
| January 27, 2022 6:30 p.m. | | at North Texas | L 66–72 | 11–7 (3–4) | UNT Coliseum (1,320) Denton, TX |
| January 29, 2022 2:00 p.m., ESPN+ | | at Rice | W 78–55 | 12–7 (4–4) | Tudor Fieldhouse (538) Houston, TX |
| February 3, 2022 6:00 p.m. | | FIU | W 65–64 | 13–7 (5–4) | Reed Green Coliseum (1,442) Hattiesburg, MS |
| February 5, 2022 2:00 p.m. | | Florida Atlantic | W 79–60 | 14–7 (6–4) | Reed Green Coliseum (1,535) Hattiesburg, MS |
| February 8, 2022 6:00 p.m. | | UTSA | W 60–57 $^{OT}$ | 15–7 (7–4) | Reed Green Coliseum (1,315) Hattiesburg, MS |
| February 10, 2022 6:00 p.m. | | UAB | L 61–68 | 15–8 (7–5) | Reed Green Coliseum (1,524) Hattiesburg, MS |
| February 17, 2022 7:00 p.m. | | at UTSA | W 66–50 | 16–8 (8–5) | Convocation Center (587) San Antonio, TX |
| February 19, 2022 1:00 p.m. | | at UTEP | L 79–86 $^{OT}$ | 16–9 (8–6) | Don Haskins Center (959) El Paso, TX |
| February 24, 2022 6:00 p.m. | | North Texas | Canceled | Canceled | Reed Green Coliseum Hattiesburg, MS |
| February 26, 2022 12:00 p.m., ESPN+ | | Rice | L 46–51 | 16–10 (8–7) | Reed Green Coliseum (1,421) Hattiesburg, MS |
| March 3, 2022 6:00 p.m. | | at UAB | W 67–57 | 17–10 (9–7) | Bartow Arena (312) Birmingham, AL |
| March 5, 2022 1:00 p.m. | | at Charlotte | L 49–70 | 17–11 (9–8) | Dale F. Halton Arena (1,009) Charlotte, NC |
| C-USA tournament ||||||
| March 9, 2022 2:00 p.m., ESPN+ | (W3) | vs. (E6) FIU Second round | W 78–60 | 18–11 | Ford Center at The Star Frisco, TX |
| March 10, 2022 2:00 p.m., ESPN+ | (W3) | vs. (E2) Middle Tennessee Quarterfinals | L 50–70 | 18–12 | Ford Center at The Star Frisco, TX |
| *Non-conference game. $^#$Rankings from AP poll. (#) Tournament seedings in parentheses. All times are in Central. ||||||
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