OpenLLM-France/wikimedia huggingface dataset:
# Tyrosine-protein kinase CSK

Tyrosine-protein kinase CSK also known as C-terminal Src kinase is an enzyme that, in humans, is encoded by the CSK gene. This enzyme phosphorylates tyrosine residues located in the C-terminal end of Src-family kinases (SFKs) including SRC, HCK, FYN, LCK, LYN and YES1.

## Function

This Non-receptor tyrosine-protein kinase plays an important role in the regulation of cell growth, differentiation, migration and immune response. CSK acts by suppressing the activity of the Src family of protein kinases by phosphorylation of Src family members at a conserved C-terminal tail site in Src. Upon phosphorylation by other kinases, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is then recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane and ultimately suppresses signaling through various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several effector molecules.

## Role in development and regulation

Tyrosine-protein kinase CSK is involved in the following developmental, metabolic, and signal transduction cascades:
Adherens junction organization, blood coagulation, brain development, cell differentiation, cell migration, cellular response to peptide hormone stimulus, central nervous system development, epidermal growth factor receptor signaling pathway, innate immune response, epithelium morphogenesis, regulation of bone resorption, negative regulation of cell proliferation, negative regulation of ERK1 and ERK2 cascade, negative regulation of Golgi to plasma membrane protein transport, negative regulation of interleukin-6 production, negative regulation of kinase activity, negative regulation of low-density lipoprotein particle clearance, negative regulation of phagocytosis, dendrocyte differentiation, peptidyl-tyrosine autophosphorylation, platelet activation, positive regulation of MAP kinase activity, regulation of cell proliferation, regulation of cytokine production, regulation of Fc receptor mediated stimulatory signaling pathway, T cell costimulation, T cell receptor signaling pathway.

## Expression and subcellular location

CSK is expressed in the lungs and macrophages as well as several other tissues. Tyrosine-Kinase CSK is mainly present in the cytoplasm, but also found in lipid rafts making cell-cell junction.

## Mutations

* Y184F – Abolishes phosphorylation.
* Y304F – Decreases activity by two-thirds and alters conformation.
* S364A – Strong decrease of phosphorylation by PRKACA (the catalytic subunit of protein kinase A).

## Clinical significance

Csk's interaction with a phosphatase ("Lyp", gene product of PTPN22) is possibly associated with the increased autoimmune diseases associated with PTPN22 mutations.
# Pumacahua metro station

Pumacahua is a Lima and Callao Metro station on Line 1. The station is located between Parque Industrial and Villa María. It was inaugurated on 28 April 1990 as part of the first section of the line between Villa El Salvador and Atocongo. However, commercial service only started on 18 January 2003, was suspended in July 2003 due to the lack of funds, and resumed only on Saturdays and Sundays on 17 January 2004. The full revenue service started on 3 January 2012, with trains running to Miguel Grau.
# Treaty of Guarantee (1960)

The Treaty of Guarantee is a treaty between Cyprus, Greece, Turkey, and the United Kingdom that was promulgated on 16 August 1960.
Article I banned Cyprus from participating in any political union or economic union with any other state. Article II requires the other parties to guarantee the independence, territorial integrity, and security of Cyprus. Article IV reserves the right of the guarantor powers to take action to re-establish the current state of affairs in Cyprus, a provision that was used for the Turkish invasion of 1974. The treaty also allowed the United Kingdom to retain sovereignty over two military bases, Akrotiri and Dhekelia.
Article IV entitled these three guarantor powers to multilateral action among them or, as a last resort if no concerted action seemed possible, each guarantor to unilateral actions confined to restoring its status according to the treaty as a democratic, bicommunal, single, sovereign independent state:
   In the event of a breach of the provisions of the present Treaty, Greece, Turkey and the United Kingdom undertake to consult together with respect to the representations or measures necessary to ensure observance of those provisions.
   In so far as common or concerted action may not prove possible, each of the three guaranteeing Powers reserves the right to take action with the sole aim of re-establishing the state of affairs created by the present Treaty.
Initially, a bicommunal independent state was at stake because of the July 1974 coup and several Turkish Cypriot enclaves being attacked at the onset of the coup. Those circumstances made Turkey claim the right to unilateral action, as provided by the treaty, by first invading and creating a bridgehead and corridor between Kyrenia and Nicosia enclave.
In the second invasion campaign, Turkish forces invaded and held on to one third of the island, resulting in effective partition of the island and secession of the parts of the island under its military control.
Turkish Cypriots and Turkey view the second invasion and the effective partition as legal, citing how bicommunalism had already ended from 1964 and onwards. They maintain that the Turkish intervention did not alter the state of affairs created by the 1960 treaties, as separated communities already existed before the intervention, after provisions guaranteeing equal status of the two communities had already been violated by Greek Cypriot amendments.
The treaty was concluded the same year that the Constitution of Cyprus was finalised, and the Zürich and London Agreement and the Treaty of Alliance between Cyprus, Greece and Turkey were written.
# Tottenham Court Road chiller

In the 1930s, London Transport Board installed an experimental refrigeration plant on the London Underground at Tottenham Court Road Underground station. The plant was operational between 1938 and 1949.
The experimental plant was built because temperature measurements through the 1930s showed that the Underground was steadily getting warmer. Although the temperatures were not at unsafe levels (peaks of 82 °F / 27.8 °C occurred at a few stations in summertime), the LTB perceived that if the trend continued, cooling in summer would be required at some time in the future, and it would be sensible to develop suitable technology.
The chiller used water as the working fluid. The evaporators consisted of indirect heat exchangers mounted in the platform tunnels which were fed water at just above 0 °C. The condenser was sited in the outflow air path of an existing tunnel cooling fan, which had been installed in a disused lift shaft at the station in 1933. The outgoing air going through the condenser was warmed by 2–3 °C, before being discharged to atmosphere.
Two descriptions of the cooling capacity exist. The first (from 1939) gives the capacity as "about half a million British thermal units per hour." The second (1982) states that it was "equivalent to melting approximately 51 tonnes of ice per day." In SI units, these are 146 kW and 197 kW respectively.
The experimental plant was not considered a success, mainly because the cooling it provided was at high cost. An extractor fan of the same cooling capacity ('cooling capacity' in the sense that a fan removes warm air in the tunnels and replaces it with cooler air from outside) used up one-eighth of the electricity of the experimental refrigeration plant. Not only that, such a fan was easier to maintain and cost less to install. In the austere post-war years, the electrical power drawn by the chiller could not be justified. It was used intermittently during the 1940s, and was decommissioned in 1949.
# Windrose 5.5

The Windrose 5.5 is an American trailerable sailboat that was designed by W. Shad Turner as a pocket cruiser and first built in 1977.
The Windrose 5.5 was developed from the Windrose 18 and was developed into the Laguna 18 in 1983.

## Production

The design was built by Laguna Yachts in Stanton, California, United States, but it is now out of production.

## Design

The Windrose 5.5 is a recreational keelboat, built predominantly of fiberglass, with wood trim. It has a fractional sloop rig with a deck-stepped mast and aluminum spars. The hull has a raked stem, a plumb transom, a transom-hung rudder controlled by a tiller and a fixed fin shoal-draft keel. It displaces 1,500 lb (680 kg) and carries 500 lb (227 kg) of ballast.
The boat has a draft of 2.25 ft (0.69 m) with the standard keel allowing ground transportation on a trailer.
The boat is normally fitted with a small 3 to 6 hp (2 to 4 kW) outboard motor for docking and maneuvering.
The design has sleeping accommodation for four people, with a double "V"-berth in the bow cabin and two quarter berths under the cockpit. The head is located just aft of the companionway steps and is a portable type. Ventilation is provided by a hatch on the foredeck. Cabin headroom is 45 in (114 cm).
The design has a PHRF racing average handicap of 288 and a hull speed of 5.4 kn (10.0 km/h).

## Operational history

In a 1994 review Richard Sherwood wrote that the, "Windrose is designed as a little cruiser and has bunks for four, with a double berth forward and two quarter berths. Space remains for cabin seating, shelf storage, and a head. This shoal-draft boat has 500 pounds of ballast in the keel. The manufacturer claims that the special shape of the keel makes Windrose track unusually well."
In a 2010 review Steve Henkel wrote, "by 1980 the design trend was toward wider boats, for extra stability as well as cabin space. Laguna Yachts and Shad Turner responded by widening the six-year-old Windrose 18 ... from seven feet to eight feet, and introducing a number of other changes. Principal among these were (a) eliminating the potentially troublesome steel centerboard and substituting instead a shallow iron-filled keel, and (b) rearranging the cabin space for more elbow room. For example, the portable head was moved aft where its use wouldn't interfere with V-berth sleepers; the settee berths in the '18' were replaced by wider quarter berths and a central seating area. Best features: The new design eliminates worry over centerboard difficulties, and provides more elbow room. Worst features: The fixed keel is too shallow to give good sailing performance compared to the Windrose 18's (despite the fact that PHRF rating for both the 18 and the 5.5 is—unfairly—identical at 288), and the keel makes launching and retrieving at a launching ramp considerably more difficult than with her comps or with the shallower-draft '18'."
# Valentin Eck

Valentin Eck (Ecchius) (c. 1494 in Lindau (Bodensee) – before 28 September 1556 in Bardejov) was a Swiss traveling humanists, Neo-Latin poet, and scholar. He had ties to the Cracow Academy and the early humanist circle in Cracow.

## Biography

Eck came from Lindau (Bodensee). He studied first at Leipzig, and in 1511-1517 at Cracow. He received a bachelor's degree from the Cracow Academy in 1513.
In 1517, Eck moved to Hungary, taking the position of the rector of the school in Bardejov. He maintained his contacts in Poland, however. In 1520-1521, he lectured in Cracow, and perhaps also in 1537-1539. He printed most of his works in the Polish royal city. He counted Rudolf Agricola Junior, Johannes Dantiscus, Joannis Vislicensis, Justus Ludwik Decjusz, and Leonard Cox among his friends.
Eck's most important work, De versificandi arte opusculum, was a manual for writing poetry; it was first published in 1515 and later reissued in 1521 and 1539. Eck was also the author of numerous poems and prose works, many of a laudatory nature, such as the panegyric celebrating Sigismund the Old's victory at the Battle of Orsha in 1514.
With Rudolf Agricola Junior, he edited and published texts by classical authors.

## Works

* Elegiacum Carmen in laudem Philippi Bervaldi, ad Rudolphum suum Agricolam... Cracoviae, 1512.
* Hymnus exhortatorius ad Cracoviam... 1514.
* Lucii Flori Bellorum Romanorum Libr. IV... 1515.
* De arte versificandi opusculum... 1515, 1521, 1539.
* Utrum prudenti Viro sit ducenda Vxor. 1518.
* Ad Clarissimos Viros, Dominum Petrum Czipser, et Andream Reuber, Bartphani populi... 1518.
* De Mundi contemptu et Virtute amplectenda Dialogus... 1519, 1528.
* Apophoreticum Carmen de Christi Natiuitate, Elegis compositum... 1520.
* De Reipublicae administratione Dialogus... 1520.
* Q. Horatii Flacci Liber de Arte Poetica ad Pisones... 1521.
* Q. Horatii Flacci Epistolarum Libri II... 1522.
* De Ratione legendi Auctores Libellus. 1525, 1534.
* Aurelii Prudentii Clementis Viri Consularis Liber Peristephanon, hymnos in laudem Sanctorum, qui Martyrio coronati sunt, complexus... 1526.
* Diui Aurelii Augustini, Hipponensis Episcopi, de Vita Christiana ad sororem suam viduam Liber I..., 1529.
* Epigrammatum Sacrorum Liber..., 1537.
* Epigrammata Pannoniae Luctui, quo Principum aliquot et insignium Virorum mortesaliique funesti Casus deplorantur... 1544.
* Elegiacon ad doctissimum Virum D. Joannem Benedictum, Cracou... Canonicum... 1545.
# Rosa Méndez Fonte

Rosa Méndez Fonte (born 1957 in Ferrol, Spain), is a Galician writer, poet, and researcher in both Galician and Spanish.

## Career

Méndez has a PhD in Humanities and is a specialist in Galician Heritage and Society from the University of A Coruña. She currently works as a researcher of Galician history at the Fernando Pessoa University in Porto, Portugal.
She is a member of the Galician Writers Association.

## Works in Galician
### Poetry

* Poemas anobelados no tempo, 2001, Espiral Maior.
* O raio verde, 2005, Espiral Maior

### Essays

* A antiga igrexa parroquial de San Xulián de Ferrol, 2000, Centro Ártabro de Estudios.
* Ferrol. Patrimonio e Sociedade, 2010, Sociedad de Cultura Valle-Inclán

### Collective works

* Poesía na noite, 1998, Caldas de Reis Town Hall.
* O patrimonio e a cultura proxectual, 2000, Provincial Council of Lugo, with Xosé Leira López. Essay
* A cidade como pretexto. Estratexias patrimoniais, 2002. Provincial Council of Lugo, with Xosé Leira López. Essay
* Alma de beiramar, 2002, Galician Writers Association. Poetry
* Negra sombra. Intervención poética contra a marea negra, 2003, Espiral Maior. Poetry
* A Coruña á luz das letras, 2008, Trifolium. Poetry
* Vivir un soño repetido. Homenaxe a Lois Pereiro, 2011, Galician Writers Association, ebook; Poetry
* A cidade na poesía galega do século XXI, 2012, Editorial Toxosoutos. Poetry
* 150 Cantares para Rosalía de Castro (2015, ebook). Poetry

## Works in Spanish
### Short story

* De un tiempo atrás, 1990
* Las horas guardan sombras, 1993

### Essay

* La conservación de los monumentos arquitectónicos en Galicia (1840-1940), 2010, Edicións Embora.

### Awards in Spanish

* Galiena do Concello de Toledo Award in 1993, for Las horas guardan sombras.
* VI Premio Concepción Arenal de Humanidades, for La conservación de los monumentos arquitectónicos en Galicia (1840-1940)

### Academic publications (selected)

* Fonte, Rosa Méndez. "Las vías romanas en Galicia: Un elemento configurador del patrimonio." Aulas no camiño: un estudio multidisciplinar da realidade galega que atravesan os camiños de Santiago. O Camiño Francés. Servizo de Publicacións, 1996.
* Fonte, Rosa Méndez. "Dinámica y construcción social del patrimonio." Antropológicas (1998): 99–103.
* Méndez Fonte, Rosa. "Siglo XIX, o el nacimiento de una nueva mentalidad patrimonial: una visión a través de la legislación jurídica del Camino de Santiago." (1999).
# Romántico

Romántico may refer to:

## Music

* El Romántico, album by José Manuel Calderón (musician) 1974
* Romántico (José José album), 1981
* Romántico, a compilation album by Gilberto Santa Rosa 2001
* Romantico (Kamikazee album), 2012

## Other

* Romántico (film), a 2005 documentary type film directed by Mark Becker
* Romántico (horse) (1935–1957), South American thoroughbred
# Rosemund Dienye Green-Osahogulu

Rosemund Dienye Green-Osahogulu (born 12 April 1956) is a Vice-Chancellor of Ignatius Ajuru University of Education that is based in Rumuolumeni Port Harcourt, Rivers State in Nigeria.
Green-Osahogulu was born in the Kingdom of Bonny in 1956. She was the first Vice-Chancellor of Ignatius Ajuru University of Education that is based in Rumuolumeni Port Harcourt, Rivers State in Nigeria. Her appointment was made by the state governor Chibuike Rotimi Amaechi in October 2013.
In 2018 she published an account of how she had been kidnapped and tortured by a band who were demanding that she paid them money from the university's account.
# Rondo Young Artist Festival

Rondo Young Artist Festival is an International Concert Showcase set up to encourage young musicians to further their musical talents. It is an independent and unaffiliated non-profit organization. The goal of the festival and organization is to build confidence in the participants, prepare them for their lives ahead, help them start their musical careers and promote the spread of classical music.
Rondo Young Artist Festival is open to all instrumentalists, vocalists, as well as chamber ensembles representing all musical traditions ages five through eighteen. The judges evaluate the participant’s technique, musicality and overall performance. Winners of the Festival perform on concert stages in New York and Connecticut including the Greenwich Arts Center, Steinway Hall, Liederkranz Foundation and Carnegie Hall, NYC. All participants receive detailed comments from the judges, and are awarded winners' certificates.
# William Dunavant

William Dunavant Jr. (December 19, 1932 – September 11, 2021) was an American cotton industrialist.

## Biography
### Early life

William Dunavant Jr. was born on December 19, 1932, to William and Dorothy Dunavant. He was educated first at The McCallie School in Chattanooga, then at Vanderbilt University, and received his bachelor's degree in Business Administration from Memphis State University. His maternal grandfather, T.J. White, was a cotton farmer from Tunica, Mississippi. His paternal grandfather, Colonel William P. Dunavant was in the railroad business and created one of the main cotton transporting railroads of the time. His father began working for T.J. White and Company at the age of 21. After White retired, the company was passed to Dunavant's father and renamed Dunavant Enterprises. When the senior Dunavant died in 1961, Dunavant inherited the company at the age of 29.

### Career

When Dunavant took over the company in 1961, it handled around 100,000 bales of cotton a year, and ninety percent of their sales were in the United States. Today, the company sells over 4 million bales of cotton to more than 80 countries around the world. Dunavant Enterprises is on the Forbes 400 list of largest private companies (Forbes Ranking) and according to the Memphis Business Journal, it is the largest private company in Memphis.
According to a 1976 article in the Memphis Commercial Appeal, "Dunavant's company was one of the first to go into 'future contracting,' whereby a farmer agrees to a price before he plants. It's a risky venture speculating on future cotton prices but Dunavant prospered while others floundered." On March 13, 2007, Dunavant was inducted into the Futures Industry Association's Hall of Fame for his work in the cotton futures business.
After a successful career in the cotton industry, Dunavant stepped down as chief executive officer in 2005. Before his retirement Dunavant completed gross sale of $225 million to China, the second-largest cotton sale in history. Although Dunavant is no longer the CEO, he intends to remain chairman of the board.
Dunavant was active in Memphis-area philanthropy, working with institutions such as Rhodes College, Memphis University School, and Boy Scouts of America. Dunavant's love of tennis inspired him to build the Memphis Racquet Club in 1972. His aspirations for a professional football team resulted in him selling the Racquet Club in 1992. Dunavant was the owner of the Memphis Showboats of the United States Football League and a principal investor in the Memphis Hound Dogs, a proposed National Football League expansion team that was rejected in 1993.

### Death

Dunavant died on September 11, 2021, at the age of 88.
# William Dummer (disambiguation)

William Dummer may refer to:
* William Dummer (1677–1761), royal lieutenant governor and acting governor of the province of Massachusetts Bay
* William Dummer (cricketer) (1847–1922), English cricketer
# William Hulle (MP for New Shoreham)

William Hulle (fl. 1397) of Lancing, West Sussex, was an English politician.
He was a Member (MP) of the Parliament of England for New Shoreham in September 1397.
# William Hulle (MP for Salisbury)

William Hulle (fl. 1399) of Salisbury, Wiltshire, was an English politician.
He was a Member (MP) of the Parliament of England for Salisbury in 1399.
# William Hull (disambiguation)

William Hull (1753–1825) was Territorial Governor of Michigan.
William Hull may also refer to:
* Bill Hull (1940–2020), American football player
* Billy Hull (born 1912), Northern Irish loyalist activist
* William Hull (architect) (1843–1934), English architect
* William Hull (artist) (1820–1880), English landscape and still-life painter
* William Hull (MP), Member of Parliament (MP) for Warwick
* William Hull (Wisconsin politician) (1815–1881), American lawyer and politician
* William E. Hull (1866–1942), American businessman and politician
* William Lovell Hull, Canadian Christian minister
* William R. Hull Jr. (1906–1977), American politician
* William Roper Hull (1856–1925), Canadian rancher and meat packer
* William Winstanley Hull (1794–1873), English liturgist and hymnwriter
# William John Storey

William John Storey (born 13 September 1978) is a British businessman, from Richmond on Thames. He has been involved with the carbonated drink brand Rich Energy since 2015.
He was educated at the Russell School in Petersham and at the Tiffin Boys School in Kingston upon Thames, and later studied maths at the University of St Andrews. He claims to have had short spells in the RAF (or possibly the ATC – accounts differ), as a professional footballer (for QPR reserves), as a professional gambler, and as a tobacco farmer in Zimbabwe. He founded a sports management company, William Storey management, though some of his filings at Companies House describe him as a 'Computer Consultant', and he traded for many years as 'Tryfan Technologies', an IT consultancy.
Storey managed the boxer Frank Buglioni, with whom he founded a fashion company named Danieli Style, and was part of an ill-fated sponsorship deal between the Haas Formula 1 team and Rich Energy. Storey led efforts to return the Rich Energy brand as a Formula 1 team sponsor in 2021 without success.
In July 2020, Storey said he was part of a consortium who were trying to purchase Sunderland Association Football Club, though the Roker Report said the claim did not "stack up", and former club CEO Jim Rodwell declined to comment upon his involvement.
# Roth, Rhein-Lahn

Roth is a municipality in the district of Rhein-Lahn, in Rhineland-Palatinate, in western Germany. It belongs to the association community of Aar-Einrich.
# Roseomonas aeriglobus

Roseomonas aeriglobus is a species of Gram negative, strictly aerobic, coccobacilli-shaped, pink-colored bacterium. The bacteria were first isolated from a laboratory air-conditioning system in South Korea, and proposed as a new species in 2017. Aeriglobus was chosen from the Latin aer (air) and globus (a sphere), to reference the shape of the bacteria, and that they were found in an air-conditioning system. Another species of Roseomonas, R. aerofrigidensis, was also isolated from an air conditioner.
The optimum growth temperature for R. aeriglobus is 25-30 °C, but can grow in the 10–30 °C range. The optimum pH is 6.0-7.0, and can grow in pH 4.0-9.0.