# TEKTIP1

TEKTIP1, also known as tektin-bundle interacting protein 1, is a protein that in humans is encoded by the TEKTIP1 gene.

## Gene

Tektin bundle interacting protein 1 (TEKTIP1) is a protein which in humans is encoded by the TEKTIP1 mRNA. The longest mRNA produced is 826 bases long.

### Aliases

Alias of the protein is C19orf71.

### Locus

The TEKTIP1 gene is located at 19p13.3.

### Transcriptional Regulation

Several predicted transcription factors may bind in the promoter region: TFDP1, PLAGL1, ZSCAN4, POU2F3.

### Chemical Interactions

Acrylamide, cisplatin, and silicon dioxide decrease expression, while butanal (butyraldehyde), and pentanal increase expression of TEKTIP1 mRNA.
Sequence orthology also suggests that valproic acid increases methylation of TEKTIP1 mRNA.

## Protein

The mRNA of TEKTIP1 is 654 nucleotides long. It contains five exons. The human TEKTIP1 protein is 209 amino acids long and has a predicted molecular mass of 24.5 kDa. The human protein has a theoretical isoelectric point of 9.1.

### Isoforms

There are two splice isoforms of the protein, X1 and X2.
X1 & X2 Isoform Orthologs :
| X1 | X2 |
| Tibetan macaque | Chimpanzee |
| Olive baboon | Olive baboon |
| Panamanian white-faced capuchin | Common marmoset |
| Golden and Black snub-nosed monkeys | Golden sub-nosed monkey |
| Elk | Elk |
| Red deer | Red deer |
| Greater horseshoe bat | Bats |
| Red fox | Polar bear |

## Characteristics & structure

TEKTIP1 is highly enriched in tryptophan and tyrosine. Additionally, the protein is semi-enriched in arginine and proline.

## Expression

TEKTIP1 is tissue specific and is found in higher levels in the kidney, testis and thymus.
In fetal development, it is found in higher levels in the Adrenal glands during weeks 16-20.
TEKTIP1 protein is said to be specific to the testis and is found in early spermatids during spermatogenesis.

## Evolution
### Orthologs

Over 240 organisms have orthologs with human gene TEKTIP1. The most distant organism with an orthologous sequence to human TEKTIP1 is the West African lungfish (estimated date of divergence of 408 MYA).
Selected Orthologs for TEKTIP1 :
| Genus and Species | Common Name | Taxonomic Group | Median Date of Divergence (MYA) | Accession # | Sequence length (aa) | Sequence Identity to Human Protein % | Sequence Similarity to Human Protein % |
| Homo sapiens | Human | Primates/Hominidae | 0 | NP_001129052.1 | 209 | 100 | 100 |
| Pan troglodyte | Chimpanzee | Primates | 6.4 | XP_003316050.1 | 209 | 98.1 | 98.6 |
| Mus musculus | Mouse | Rodentia | 87 | NP_001014836.2 | 217 | 45.6 | 60.4 |
| Bos taurus | Cow | Artiodactyla | 94 | NP_001070550 | 208 | 76.6 | 84.2 |
| Panthera tigris | Tiger | Carnivora | 94 | XP_042833719.1 | 210 | 34.1 | 38.9 |
| Orcinus orca | Killer whale | Cetacea | 94 | XP_012394771.2 | 216 | 63 | 73.1 |
| Phascolarctos cinereus | Koala | Diprodontia | 160 | XP_020824948.1 | 211 | 52.9 | 67.4 |
| Haliaeetus leucocephalus | Bald Eagle | Accipitiformes | 319 | XP_010580112.1 | 206 | 41.4 | 52 |
| Dromaius novaehollandiae | Emu | Aves | 319 | XP_025961204.1 | 190 | 44.8 | 56.7 |
| Gallus gallus domesticus | Chicken | Aves | 319 | XP_015155269.2 | 188 | 38.2 | 48.4 |
| Crocodylus porosus | Saltwater Crocodile | Crocodilia | 319 | XP_019406144.1 | 210 | 54.3 | 68.3 |
| Caretta caretta | Loggerhead Sea Turtle | Testudines | 319 | XP_048687032.1 | 216 | 47.8 | 57.3 |
| Zootoca vivipara | Common lizard | Squamata | 319 | XP_034975173.1 | 200 | 48.8 | 59.5 |
| Crotalus tigris | Tiger Rattlesnake | Squamata | 319 | XP_039190693.1 | 199 | 45.8 | 57.5 |
| Protobothrops mucrosquamatus | Venomous Pit Viper | Squamata | 319 | XP_015665555.1 | 199 | 45.1 | 56.7 |
| Bufo bufo | Common Toad | Salientia | 353 | XP_040276375 | 136 | 24.7 | 34.3 |
| Geotrypetes seraphini | Gaboon Caecilian | Caecilians | 353 | XP_033813379.1 | 156 | 36.1 | 45.8 |
| Microcaecilia unicolor | Tiny Caecilian | Caecilians | 353 | XP_030074922.1 | 142 | 34.3 | 42.6 |
| Protopterus annectens | West African Lungfish | Actinopterygii | 408 | XP_043910031.1 | 142 | 28.6 | 39 |