OpenLLM-France/wikimedia huggingface dataset:
# Ibrexafungerp

Ibrexafungerp, sold under the brand name Brexafemme, is an antifungal medication used to treat vulvovaginal candidiasis (VVC) (vaginal yeast infection). It is taken orally (by mouth). It is also currently undergoing clinical trials for other indications via an intravenous (IV) formulation. An estimated 75% of women will have at least one episode of VVC and 40 to 45% will have two or more episodes in their lifetime.
Ibrexafungerp acts via inhibition of glucan synthase, which prevents formation of the fungal cell wall.
Ibrexafungerp was approved for medical use in the United States in June 2021. It is the first non-azole oral antifungal drug to be approved by the U.S. Food and Drug Administration (FDA) for the treatment of vaginal yeast infections. The FDA considers it to be a first-in-class medication.

## Medical uses

Ibrexafungerp is indicated for the treatment of adult and postmenarchal pediatric females with vulvovaginal candidiasis (VVC).
Ibrexafungerp is currently undergoing late-stage clinical trials for an intravenous formulation for the treatment of various fungal diseases, including life-threatening fungal infections caused primarily by Candida (including C. auris) and Aspergillus species. It has demonstrated broad-spectrum antifungal activity, in vitro and in vivo, against multidrug-resistant pathogens, including azole- and echinocandin-resistant strains.

## Pharmacology
### Pharmacodynamics

Ibrexafungerp is a triterpenoid antifungal agent. It acts via inhibition of the enzyme glucan synthase, which is involved in the formation of 1,3-β-D-glucan—an essential component of the fungal cell wall. The compound has concentration-dependent fungicidal activity against Candida species.

### Pharmacokinetics

Ibrexafungerp has a time to maximal concentrations of 4 to 6 hours. It is metabolized by hydroxylation via CYP3A4 and subsequently by glucuronidation and sulfation. The medication has an elimination half-life of approximately 20 hours.
# Thomas Smyth (merchant)

Thomas Smyth (1737? – 1824) was an English merchant, banker and Lord Mayor of Liverpool.

## Life

He was son of Thomas Smyth of the Middle Temple, the sixth son of Bishop Thomas Smyth.
Smyth was partner with Charles Caldwell in Charles Caldwell & Co., a Liverpool bank. He became a shareholder (holding joint with Caldwell) in the Macclesfield Copper Company, known as Roe and Co. after its founder Charles Roe, in 1774.
Smyth was a lessee on behalf of Roe and Co. of land near Llandudno from Lord Penrhyn, by an agreement of 1785. On 12 October 1788 Lord Penrhyn visited Merseyside, riding the liberties of the borough of Sefton, and Smyth accompanied him. The occasion was seen as largely political and symbolic, part of the contest between Lord Penrhyn, whose title was in the Peerage of Ireland and who was the sitting Member of Parliament for Liverpool at the time, and Banastre Tarleton.
Smyth was Lord Mayor of Liverpool in 1789–1790. An important issue for Liverpool Corporation at the period was the development of Liverpool Docks. Smyth undertook negotiations with Lord Sefton over a lease in the Harrington area, for planned expansion. That lease was currently held by Roe & Co. The negotiation failed, however, Lord Sefton expressing a wish not to have the area developed with labourers' houses.
The 1790 British general election fell in the summer, towards the end of Smyth's term of office. Lord Penrhyn and Bamber Gascoyne the younger were candidates posing as defenders of Liverpool's commercial interests, against abolitionists, such as Tarleton. Feelings ran high, and Smyth called a noon meeting on 16 June outside the Liverpool Exchange. He warned of violence, and attempted a straw poll by show of hands. But Tarleton had much support, and was not faced down.
Smyth's term as mayor also brought to the surface a related sharp rivalry with John Sparling, his successor the following year. Smyth manoeuvred to bring his partner Caldwell into the Corporation; in retaliation Sparling tried to bring in supporters of his own. Sparling and his bailiffs, one of whom was Clayton Tarleton (brother to Banastre Tarleton), were impugned by a comment Smyth had minuted for illegal acts. The matter went to a court case.
Smyth became bankrupt in 1793, when the bank failed, hit by the fall in the price of cotton at the outbreak of the French Revolutionary Wars. Losing most of his possessions, Smyth was able to remain at Fair View, Toxteth Park, by arrangement with his landlord William Roe, son of Charles Roe. An estate in Macclesfield, that had come through his wife, remained unaffected. The impact in Liverpool of the failure of Charles Caldwell & Co. was serious on business confidence, and there was a failed attempt to obtain a loan from the Bank of England. The Corporation resolved the financial crisis by an Act of Parliament allowing it to issue banknotes.
Smyth died, aged 87, at Fence House in Macclesfield, on 12 July 1824.

## Family

Smyth married Elizabeth Blagg or Blagge of Macclesfield in 1762 at Prestbury. Their children included William Smyth.
# TU (time unit)

In some data communication standards, a time unit (TU) is equal to 1024 microseconds. This unit of time was originally introduced in IEEE 802.11-1999 standard and continues to be used in newer issues of the IEEE 802.11 standard.
In the 802.11 standards, periods of time are generally described as integral numbers of time units. The unit allows for maintaining intervals that are easy to implement in hardware that has a 1 MHz clock (by dividing the clock signal in half ten times, rather than operating a phase-locked loop or digital divider to divide such a clock signal by 1000).
One time unit is equal to one millionth of a kibisecond (1 TU = 10$^{−6}$ Kis).
# Sawasa

Sawasa was a Sinhala language daily evening newspaper in Ceylon published by Independent Newspapers Limited, part of M. D. Gunasena & Company. It was founded on 1963 and was published from Colombo. In 1966 it had an average net sales of 34,000. It had an average circulation of 18,812 in 1973.
By 1973/74 the Independent Newspapers publications had become vocal critics of Sirimavo Bandaranaike's government. The government sealed Independent Newspapers' presses and closed it down on 19 April 1974 using the Emergency (Defence) Regulations. Independent Newspapers resumed publication on 30 March 1977 but the three-year closure had taken its toll. Faced financial problems Independent Newspapers and its various publications closed down on 26 December 1990.
# Tomoplagia minattai

Tomoplagia minattai is a species of tephritid or fruit flies in the genus Tomoplagia of the family Tephritidae.

## Distribution

Argentina.
# When Will You Fall for Me

"When Will You Fall for Me" is a song by Australian musical duo Vika and Linda. The song was written by Mark Seymour and was released as the first single from their debut studio album, Vika and Linda (1994), on 9 May 1994. The single peaked at number 51 on the Australian ARIA Singles Chart in July 1994 and remained within the top 100 for 16 weeks.
The duo recorded a ballad version of the song on their 2000 album, Live & Acoustic (Vika and Linda album) and a reggae version on their 2006 album, Between Two Shores.

## Track listing

Australian CD single (D11690)
* "When Will You Fall for Me?"
* "Brand New Ways"

## Charts

| Chart (1994) | Peak position |
| Australia (ARIA) | 51 |
# Multi Protocol File System

The Multi Protocol File System (MPFS) is a multi-path network filesystem technology developed and sold by EMC Corporation. MPFS is intended to allow hundreds to thousands of client computer nodes to access shared computer data with higher performance than conventional NAS file-sharing protocols such as NFS.

## Description

MPFS technology is intended for HPC (High Performance Computing) environments in which multiple compute nodes require concurrent access to data sets. This technology can be used to store and access data for grid computing, where the individual computing power of many systems is combined to perform a single process. Example uses include processing geological data, voice recognition datasets, and modal processing. Virtualized computing environments will also benefit from high performance shared storage.
MPFS consists of an agent on the client system and a compatible NAS storage system. The client agent splits the data and meta data for the file being requested. This is done using an FMP (File Mapping Protocol). Requests for the data and its location are sent over conventional NFS to the NAS system. Block data is sent and retrieved directly from the storage device via iSCSI or Fibre Channel. Retrieving data directly from the storage device increases performance by eliminating the file system and protocol overhead associated with NFS or SMB.
The MPFS protocol was developed by EMC for use in NAS storage environments utilizing EMC Celerra and back end storage environments such as the EMC CLARiiON, EMC VNX and Symmetrix.
# Whatcha Gonna Do? (song)

"Whatcha Gonna Do?" is a song by American rock group Pablo Cruise. This song was written by David Jenkins and Cory Lerios, two of the band's members. "Whatcha Gonna Do?" was a track from their album A Place in the Sun in 1977.

## Chart performance

It was released as a single and reached #6 on the Billboard Hot 100. "Whatcha Gonna Do" was also a minor hit on the Billboard's Hot Soul Singles chart, where it peaked at #46.
In Canada, "Whatcha Gonna Do?" reached #1 on the pop singles chart. It is ranked as the 24th biggest Canadian hit of 1977. Billboard ranked it as the #16 song of 1977.
# Juan Moreno Yagüe

Juan Ignacio Moreno de Acevedo Yagüe (born 1973), better known as Juan Moreno Yagüe, is a Spanish lawyer, activist and politician. He is a specialist in banking, mortgages, and criminal and economic law.

## Biography

Born on 29 May 1973 in Salamanca to a family with a tradition in law, his mother a teacher and his father a judge, he is married with two children. He was raised in Villafranca de los Barros, Plasencia and Montijo before moving at age nine to Seville. After earning a Licentiate degree in Law, he unsuccessfully tried to pass the competitive public examinations in order to become a judge; he desisted and founded a law firm instead.
He took part in the 15-M Movement through ¡Democracia Real YA!. He also participated in the anti-eviction movement. Keen of the online alias hackabogado, Moreno Yagüe, promoter of initiatives such as Democracia 4.0, and #Opeuribor. He has been (2012-2014) one of the lawyers hired by 15MpaRato movement, the citizen platform that uncovered the Bankia Case that brought Rodrigo Rato to trial. He has taken part in the X Party since its inception, he ran 6th in the party list for the 2014 European Parliament election in Spain. The party failed to obtain representation. Moreno Yagüe ran 2nd in the Podemos list for Seville vis-à-vis the 2015 Andalusian regional election, and, elected, became a member of the 10th term of the Parliament of Andalusia, where he served as 3rd Vice-President of the governing board of the legislature.
In February 2017, he contested the Podemos leadership voting to determine the party's Secretary-General in the 2nd Citizen Assembly ("Vistalegre II"), presenting himself as the single alternative to the leadership of Pablo Iglesias. Running in a platform vouching for direct democracy, energy transition and free knowledge, he commanded the support of 15,700 members (10.9%) vs the 128,700 votes (89%) commanded by Iglesias. His policy manifesto was focussed on electronic voting and eliminating the bank payment system, replacing banks with a mobile application where each person manages his or her own money without having to rely on a bank to manage it.
In August and October 2017, he published two legal analyses on the unconstitutionality of the Spanish State Government's intervention of the Autonomy of Catalonia, in particular of the agreements relating to the application of Article 155 of the Spanish Constitution.
# Lake Eacham, Queensland

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Lake Eacham is a rural locality in the Tablelands Region, Queensland, Australia. In the 2021 census, Lake Eacham had a population of 459 people.

## Geography

The locality is bounded to the west and south-west by Lake Barrine Road and to the south-east by Malanda Creek.
The locality presumably takes its name from the waterbody Lake Eacham in the north-west of the locality (17°17′04″S 145°37′31″E﻿ / ﻿17.2845°S 145.6252°E﻿ / -17.2845; 145.6252﻿ (Lake Eacham (Queensland))). The name of the lake is believed to be an Aboriginal word ''yeetcham'' meaning ''big spring''. The lake and its surrounds are within the Crater Lakes National Park.
There is rural residential housing to the south and east of the national park. However, the predominant land use in the locality is grazing on native vegetation.

## History

The land in the area was surveyed in 1886 with farm lots being offered for sale in 1889.
Lake Eacham State School opened on 1911. It was built by the Sydes Brothers, who were chosen from the tenders called in September 1910. A teacher's residence was built in 1917. In 1919, it was renamed Peeramon State School. It closed in 1959. It was at 107 Mckenzie Road (corner Peeramon School Road, 17°18′36″S 145°37′26″E﻿ / ﻿17.3099°S 145.6239°E﻿ / -17.3099; 145.6239﻿ (Peeramon State School)) in neighbouring Peeramon.

## Demographics

In the 2016 census, Lake Eacham had a population of 457 people.
In the 2021 census, Lake Eacham had a population of 459 people.

## Education

There are no schools in Lake Eacham. The nearest primary schools are Yungaburra State School in neighbouring Yungaburra to the north-west, Malanda State School in neighbouring Malanda to south-west, and Butchers Creek State School in neighbouring Butchers Creek to the south-east. The nearest secondary school is Malanda State High School in Malanda.

## Attractions

Lake Eacham has a day use area with a lookout on Lakes Drive (17°17′10″S 145°37′43″E﻿ / ﻿17.2862°S 145.6287°E﻿ / -17.2862; 145.6287﻿ (Lake Eacham Day Use Area Lookout)). It is the start and finish of a circuit walking track around the lake.
# TWSG1

Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene. The protein is a binding protein for bone morphogenetic proteins, similar to Chordin. The Twisted gastrulation gene is expressed in the extraembryonic tissues during organogenesis, and in certain adult tissues such as the lymph nodes, kidneys, liver, and lungs.
# Sciocoris sideritidis

Sciocoris sideritidis is a species of shield bug belonging to the family Pentatomidae, subfamily Pentatominae.
The head is quite characteristic and stretched with the ante-ocular part closer than in other species. Its eyes are prominent from the edge of the head. Scutellum is about as wide as long.
It is mainly found in France and Italy.
# Tony Meléndez

José Antonio Meléndez Rodríguez (born January 9, 1962) is a Nicaraguan-American guitar player, composer, singer, and songwriter who was born without arms. His mother took thalidomide while pregnant, which caused his disability. Meléndez has learned to play the guitar with his feet.

## Career

Meléndez began playing and singing in the Los Angeles area in 1985. On September 15, 1987, Meléndez sang Never Be the Same while playing the guitar with his feet in a special performance for Pope John Paul II. Visibly moved, the Pope descended from his chair and embraced Meléndez. The Pope told Meléndez, "My wish to you, is to continue of giving [sic] this hope to all, all the people," which inspired him.
His band, Tony Meléndez and the Toe Jam Band, has a busy concert schedule. Meléndez gives motivational talks and has written a book. He campaigns actively for the anti-abortion cause.
Meléndez now resides in Branson, Missouri with his wife, Lynn.

## Awards and recognition

Meléndez has won Unity Awards Male Vocalist of the Year UCMVA in 2000, 2002, and 2004, and. In 2002, he took Artist of the year. He received the Branson Entertainment Award for Best New Artist in 1999, the "Inspirational Hero Award from the NFL Alumni Association at the Super Bowl XXIII and has received special commendations from the State of California for his work with young people and from President Reagan, regarding Tony "as a positive role model for America".
Meléndez spoke candidly about the effect disability had on his life and work in the book Chronicles of Courage: Very Special Artists written by Jean Kennedy Smith and George Plimpton and published by Random House.
* Special Commendation from President Reagan — As A Positive Role Model for America
* Special Commendation from State of California - For Work with Young People
* Inspirational Hero Award from the NFL Alumni Association at Super Bowl XXIII in Miami
* Branson Entertainment Awards – Best New Artist (1999)
* Unity Awards — Male Vocalist of the Year UCMVA (2000)
* Unity Awards — Artist of the Year UCMVA (2002)
* Unity Awards — Male Vocalist of the Year UCMVA (2002)
* Unity Awards — Male Vocalist of the Year UCMVA (2004)

## Discography

* Never be the Same (1988)
* Ways of the Wise (1990)
* El Muro Se Callo (1991)
* Debe Haber (1995)
* Hands in Heaven (1997)
* The Cup of Life (1998)
* Intimate Worship (1999)

## Published works

* A Gift of Hope (1991)

## Sources

* 1 2 "Dancing Without Arms". ProLife.com. Retrieved July 1, 2009.
* ↑ "Papal Performance Tony Internet Vids H 264 LAN". YouTube. February 3, 2009. Archived from the original on December 21, 2021. Retrieved April 1, 2013.
* 1 2 3 4 "Tony Melendez: Biography". TonyMelendez.com. Retrieved July 1, 2009.
# Les Bidasses en folie

Les Bidasses en folie is a French comedy film directed by Claude Zidi (in his director debut) released in 1971.

## Plot

Five catastrophe-prone friends—Gérard, Phil, Jean-Guy, Jean and Luis—decide to leave home and start a rock band. They find a supporter in Crème, a young woman who runs a musical instruments shop and believes in them. She enters them in a battle of the bands which turns out to be rigged, but they win despite unleashing mayhem on stage when she cheats on their behalf.
Unfortunately for them, the young men are then called up for their military service. In order to be able to take part in the next competition, they set about being kicked out by being as incompetent and uncooperative as they can be. Their musical talents are however put to use by their commanding officer, who requisitions them to play his daughter's wedding reception. Eventually, the colonel kicks them out with the exception of Gérard, whom he decides to keep as his aide. The other four, briefly delighted to be out, return for him.

## Cast

* Gérard Rinaldi ... Gérard
* Gérard Filippelli ... Phil
* Jean Sarrus ... Jean
* Luis Rego ... Luis
* Jean-Guy Fechner ... Jean-Guy
* Jacques Dufilho ... colonel
* Jacques Seiler ... Sergeant Bellec
* Marion Game ... Crème
* Martin Circus ... themselves
* Triangle ... themselves
* Christian Fechner ... customer at the restaurant
* Francis Lemaire ... fiancé of the colonel's daughter
# Mudaria leprosticta

Mudaria leprosticta is a moth of the family Noctuidae first described by George Hampson in 1907. It is found in Sri Lanka.
# White piedra

White piedra (or tinea blanca) is a mycosis of the hair caused by several species of fungi in the genus Trichosporon. It is characterized by soft nodules composed of yeast cells and arthroconidia that encompass hair shafts.

## Signs and symptoms

White piedra is asymptomatic.

## Diagnosis

White piedra is caused by Trichosporon beigelii. White piedra can occur on the hair of the scalp; Trichosporon ovoides is likely the cause in this case. White piedra on scalp hair is rarely caused by Trichosporon inkin; pubic hair with white piedra is what T. inkin is mainly associated with. White piedra can occur on pubic hair; T. inkin likely causes this.
Trichosporon mucoides can also cause white piedra. In such cases, a periodic acid-Schiff–diastase stain and fungal culture may aid in diagnosis.

## Treatment

There are several approaches to treat this infectious disease. One approach involves shaving the affected areas. Another approach involves the use of antifungal medication, such as ketaconazole shampoo.
# Small nucleolar RNA Z162

In molecular biology, Small nucleolar RNA Z162 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
snoRNA Z162 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.
Plant snoRNA Z162 was identified in a screen of Oryza sativa.
# Predatory educator

A predatory educator is an organization that exploits people by selling them education that cannot live up to the promises made.
In many cases predatory educators are most expert at helping students access various forms of financial aid – helping them complete paperwork that will free up financial assistance that will allow the student to purchase more education. In the US it is common for such schools to get as much as 90% of their revenue from federal student aid programs.

## Comparison with diploma mills

Predatory educators are different from what are commonly known as diploma mills. Strictly speaking the term diploma mill is most commonly used to describe an entity that issues counterfeit diplomas bearing the names of real universities.

## Comparison with degree mills

A degree mill issues diplomas from unaccredited institutions which may be legal in some states but are generally illegitimate. This is not the case with predatory educators who generally are accredited and typically rely on that accreditation to access government funding.

## Legislation

Predatory educators are often enabled by government programs designed to provide students with access to paid education. In the US for example the 1998 $3.1 billion Workforce Investment Act provides students with vouchers worth $3,000 to $5,000 to help them acquire training. Although it is a federal program state and local officials decide what schools and programs are eligible to receive the funds, and have been criticized for not providing adequate oversight.
The Obama administration attempted protecting students by forcing colleges to disclose the information required to help students make good decisions, and enforcing performance by limiting access to government funds:

### Certification requirements

Institutions must certify that each of their gainful employment programs meets applicable institutional or program-level accreditation requirements and state or federal licensure standards.

### Accountability metrics

To maintain Title IV eligibility, gainful employment programs will be required to meet minimum standards measured by two metrics: debt-to-earnings and program cohort default rate. A program becomes ineligible to provide Title IV aid for 3 years if it fails in any 2 out of 3 consecutive years
OR
It is in the zone (or a combination of being in the zone and failing) for 4 consecutive years. A program becomes ineligible to provide Title IV aid for 3 years if it fails for 3 consecutive years.

### Disclosures

Institutions will be required to make public disclosures regarding the performance and outcomes of their gainful employment programs. The disclosures include information on costs, earnings, debt, default rates, and completion rates.

### American Bar Association

The American Bar Association requires accredited American law schools to disclose the "employment outcomes" of graduates.
# Lago della Malgina

Lago della Malgina is a lake in the Province of Bergamo, Lombardy, Italy.
* This Lombardy location article is a stub. You can help Wikipedia by expanding it.
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