OpenLLM-France/wikimedia huggingface dataset:
# SLC22A5

SLC22A5 is a membrane transport protein associated with primary carnitine deficiency. This protein is involved in the active cellular uptake of carnitine. It acts a symporter, moving sodium ions and other organic cations across the membrane along with carnitine. Such polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for the elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Mutations in the SLC22A5 gene cause systemic primary carnitine deficiency, which can lead to heart failure.

## Structure

The SLC22A5 gene, containing 10 exons, is located on the q arm of chromosome 5 in position 31.1 and spans 25,910 base pair. The gene produces a 63 kDa protein composed of 557 amino acids. The protein has 12 putative transmembrane domains, with a long extracellular loop of 107 amino acids between the first two transmembrane domains and an intracellular loop between the fourth and fifth transmembrane domains. This long extracellular loop has three potential sites for N-glycosylation, and the intracellular loop has an ATP/GTP binding motif. In putative intracellular domains, there are five potential sites for protein-kinase C-dependent phosphorylation and one for protein-kinase A-dependent phosphorylation.

## Function

The SLC22A5 gene codes for a plasma integral membrane protein which functions as both an organic cation transporter and a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine, transporting one sodium ion with one molecule of carnitine. Organic cations transported by this protein include tetraethylammonium (TEA) without involvement of sodium. The relative uptake activity ratio of carnitine to TEA is 11.3.

## Clinical Significance

The main phenotypical effect of autosomal recessive mutations, either compound heterozygous or homozygous, in the SLC22A5 gene is systemic primary carnitine deficiency, characterized by impaired carnitine transport, urinary carnitine wasting, low serum carnitine levels, reduced intracellular carnitine accumulation, impaired beta oxidation, and cytosolic fatty acid accumulation. Patients often display metabolic decompensation, hypoketotic hypoglycemia, hepatic encephalopathy, Reye syndrome, and sudden infant death in their first year, followed by the later onset of cardiomyopathy or skeletal myopathy, arrhythmias, muscle weakness, and heart failure in early childhood. Patients may be asymptomatic, with about 70% of asymptomatic patients having a missense mutation or in-frame deletion; nonsense mutation frequency is increased in symptomatic patients. The symptoms and outcome of the disease can be drastically improved by replacement therapy with L-carnitine. The estimated incidence of primary carnitine deficiency in newborns is about 1 in 40,000.

## Interactions

SLC22A5 interacts with PDZK1.
# James E. Martin

James Everett Martin (June 22, 1932 – June 3, 2017) was the President of the University of Arkansas from 1980 to 1984, and of Auburn University from 1984 to 1992.

## Biography

James Everett Martin was born on June 22, 1932, in Vinemont, Alabama. He graduated from Auburn University with a B.S. in 1954, an M.A. from North Carolina State University in 1956 and a PhD from Iowa State University in 1962.
He was a professor at Oklahoma State University and the University of Maryland. He served as Dean of Agriculture and Life Sciences at Virginia Polytechnic Institute and State University. In 1975, he was appointed as vice president for the Division of Agriculture at the University of Arkansas. He was then its president from 1980 to 1982,and became the first president of the University of Arkansas System from 1982 to 1984. From 1984 to 1992, he served as the President of Auburn University until he retired.
He was a member of the Auburn Rotary Club. The James E. Martin Aquatics Center is named after him.
During his college days at Auburn, James met an Auburn cheerleader named Ann Freeman. They later married and had three children, and five grandchildren.
He died on June 3, 2017, at the age of 84.
# Vizslás

Vizslás is a village in Nógrád County, Northern Hungary Region, Hungary.
# Pihke

Pihke is a village in Saarde Parish, Pärnu County in southwestern Estonia.
# I Come for to Sing

I Come for to Sing was a folk music revue performed by Chicago musicians and singers Win Stracke, Big Bill Broonzy and Lawrence Lane. The program was narrated by Studs Terkel. I Come for to Sing ran successfully for more than ten years, touring colleges and clubs throughout the United States, with the bulk of the activity taking place in the Midwest. Most notably, the show ran for more than a year at the now defunct Chicago jazz club, The Blue Note.
In a 2007 article in the Chicago Tribune, Terkel remembered his years with I Come for to Sing,
   In the late 1940s and early 50s, Win and I, plus Big Bill Broonzy and Larry Lane visited universities throughout the country. It was a program of folk songs with different epochs. Win sang frontier ballads, Big Bill sang a black man's blues and Larry Lane sang Elizabethan ballads. I was the narrator. It was received with great amazement and enthusiasm. We often crossed paths with Pete Seeger and The Weavers, who were of course, masters of the milieu.
Cast members rotated in and out over the years and included banjo player Fleming Brown, pianist Chet Roble and other performers who happened to be available, but the format of the show remained constant. The narrator set the tone for the evening by reading some prose or poetry or adding commentary, and the musicians reflected on that theme by performing folk songs from different musical traditions.
It is notable as the meeting place for the founders of the Old Town School of Folk Music. The Old Town School also published a folk magazine with the same name from 1975 to 1987.
# Zadorra

The Zadorra is a river tributary of the Ebro in the Basque Country in the north of the Iberian Peninsula. The river flows primarily across Álava province (flowing briefly through the Treviño enclave at La Puebla de Arganzón) finally reaching the Ebro near Miranda de Ebro in Burgos province, Castille and León. The river's water volume is the largest in Álava, with its basin being the most extensive in the province. Nowadays it provides by means of the Zadorra Reservoir System (comprising reservoirs Uribarri-Ganboa, Urrunaga and Albina) water supply for Vitoria and half of the Basque Autonomous Community.
The river rises in the slopes of the Entzia Plateau at the spring known as Los Corrales (municipality of San Millán/Donemiliaga), meandering thereafter across the Alavan Plains to the west (loops around Agurain/Salvatierra) past Vitoria by the north, where it takes a turn to the south heading to the Ebro through La Puebla de Arganzón.

## Landmarks

* The village and iconic castle of Gebara sit by the river on its middle stage.
* The Zadorra Reservoir System starting in Uribarri-Ganboa (built as of 1947).
* The Battle of Vitoria took place on a stretch extending 18 kilometres (11 mi) on the banks of Zadorra from La Puebla de Arganzon to Trespuentes to Mendoza.
* The site of old Basque-Roman town Iruña-Veleia is across the river from Trespuentes.

## Pollution

The Zadorra is the most important river in Álava and is also the most polluted. It ranks in the top six polluted rivers in the Basque Country.
More than 2,754 waste disposals have been authorised, 1,783 (65%) of which are urban and 960 (35%) of to which are industrial. From the 960 industries 89 of them are subject integrated environmental authorization. Unauthorized waste disposal also must be taken into account for the pollution. Additionally, waste dumped by industries is often more polluted than it should be.
The oxygen levels in the Zadorra are below the standards required for the wildlife in the river. The river's situation is also aggravated by the presence of toxins. The level of toxins is above the amount allowed by the European Union. Fifteen wastewater treatment plants have helped stopping the advance of the pollution in the river. The kind of insects that nest in the river are an indicator of the degradation of the Zadorra. Because the insects show in the top of the river what is happening in the bottom of it. In addition, nitrates have appeared in the river, despite the amount of nitrates being low, there should not be any nitrates.
In 2008 the Ebro's hydrographic confederation published a report about some of the rivers around the Ebro, including the Zadorra river. The investigation, which measured pollution in the rivers over four years, started in 2004. The report showed that the amount of pollution found in the river was well over the permitted amount. As a result, the municipalities have started some control programmes for the authorization of waste disposal. The control programmes have brought about some reduction in pollution.
# Op. 91

In music, Op. 91 stands for Opus number 91. Compositions that are assigned this number include:
* Beethoven – Wellington's Victory
* Brahms – Two Songs for Voice, Viola and Piano
* Britten – Sacred and Profane
* Delius – Two Songs to be sung of a summer night on the water
* Dvořák – In Nature's Realm
* Glière – Horn Concerto
* Margola – Cello Concerto
* Schumann – Romanzen volume II (6 partsongs for women's voices)
* Sibelius – Jäger March (Jääkärimarssi), military march for male choir and orchestra (1917)
# Paramorbia ithyclina

Paramorbia ithyclina is a species of moth of the family Tortricidae. It is found in Colombia.
# SLC22A24

Solute carrier family 22 member 24 is a protein that in humans is encoded by the SLC22A24 gene.

## Function

SLC22A24 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).
# The Last Dragon (disambiguation)

The Last Dragon is a 1985 martial arts musical film.
The Last Dragon may also refer to:

## Arts and literature

* The Last Dragon (2004 film), a British film
* The Last Dragon (novel), a 2004 children's novel by Silvana De Mari
* The Last Dragon Chronicles, a series of novels by Chris d'Lacey
* Raya and the Last Dragon, a 2021 film
* "The Last Dragon", the twelfth episode of Legend of the Dragon
* "The Last Dragon", the thirty-second episode of Mysticons

## Music

* The Last Dragon (soundtrack), soundtrack to the 1985 film
* The Last Dragon, a 2013 album by The Regime
* Last Dragon, a 2015 album by Sisqó, or its title track
* "Last Dragon", a 2016 song by Eric Prydz from Opus
# Viztel Solutions Group

Viztel Solutions Berhad is involved in the business of developing and marketing of voice technologies and telecom software services.
It is a fast-growing technology firm that was publicly listed on the MESDAQ Market of Bursa Malaysia (MESDAQ: VIZTEL, 0050) since July 2004. The Group has business presence in South East Asia, Greater China, Middle East and USA.

## History

Viztel Solutions Group or Viztel Solutions Berhad was founded in 1999 by 4 engineers, namely Lau Kin Wai, Pang Hao Chen, Chong Kam Hoe and Tan Heng Kiat.
# Johannes Lello

Johannes Lello (25 November 1895 – 26 November 1976) was an Estonian footballer. He played in three matches for the Estonia national football team in 1924. Lello was part of the Estonian team at the 1924 Summer Olympics in Paris.
# Piermaria Bagnadore

Piermaria Bagnadore (c. 1550–1627), also called Pietro Maria Bagnatori, was an Italian painter, sculptor, and architect of the late-Renaissance period.

## Biography

Born in Orzinuovi, he trained with il Moretto da Brescia, and painted mainly in Brescia from the late 16th century until the 1610s.
Bagnadore spent most of his career in Brescia. He helped direct the sculptural decoration of the Duomo Nuovo between 1604 and 1611 and sculpted the Mannerist style fountain at the base of the Torre della Palata, with collaborations from Antonio Carra and Valentino Bonesini. Among his other works is the design of the Church of the Madonna del Lino during 1604–1609. He also participated in the reconstruction of the church of San Domenico (1611) and the church of Sant'Angela Merici.
Bagnadore also assisted in designing the bell-tower of the church of San Giuseppe, the monumental portico in via Dieci Giornate as well as the Zanardelli at Piazza dell Loggia. He was also involved in planning the enlargement of the church of Santissimo Corpo di Cristo (1620).
Equally famous for his paintings, Bagnadore's works include the Birth of Jesus for the church of San Carlo, and Adoration of Shepherds over the lateral portal of the church of Santa Maria delle Grazie, along with a St Anne and young John the Baptist and an altarpiece depicting the Immaculate Conception; and a Dead Christ for the nave of Sant'Angela Merici.
His work was noted by the biographer Luigi Lanzi and his extensive print collection passed into the hands of Count Camillo Gonzaga of Novellara
# Kösreli, Gerede

Kösreli is a village in the Gerede District, Bolu Province, Turkey. Its population is 39 (2021).
# Yuki Yoshimura (baseball)

Yuki Yoshimura (吉村 裕基, Yoshimura Yūki, born June 14, 1984 in Koga, Fukuoka, Japan) is a professional Japanese baseball player for De Glaskoning Twins [nl] of Honkbal Hoofdklasse. He previously played for the Yokohama BayStars, Yokohama DeNA BayStars and Fukuoka SoftBank Hawks of Nippon Professional Baseball (NPB).
On April 17, 2019, he signed with the De Glaskoning Twins [nl] of Honkbal Hoofdklasse.
# Pardomima martinalis

Pardomima martinalis is a moth in the family Crambidae. It was described by Viette in 1957. It is found on São Tomé.
# Hospital 12 de Octubre (Madrid Metro)

Hospital 12 de Octubre is a station on Line 3 of the Madrid Metro, serving the Hospital Universitario 12 de Octubre. It is located in fare Zone A.
# The Last Dragonlord

The Last Dragonlord is the first in a series of books written by Joanne Bertin. It takes place in a world of truehumans, truedragons, and dragonlords - beings that have both human and dragon souls and can change from human to dragon and vice versa at will.
The Last Dragonlord refers to a central character of the book, Linden Rathan, so called because he is the last dragonlord to have been born in more than 600 years. He is also the only dragonlord without a soultwin, who is another dragonlord with the other half of his dragon and human souls.
The Last Dragonlord was published in 1998. It was followed by two sequels, Dragon and Phoenix in 1999 and Bard's Oath in 2012.

## Plot introduction

The Dragonlords watch over the Five Kingdoms, serving as impartial juries in disputes between kingdoms or involving high ranking nobles as they are seen as above the common interests due to their extremely long lives. When the Queen of Cassori dies in suspicious circumstances, leaving behind only a young son as her heir, Linden and the two other dragonlords are called in to investigate, and prevent a civil war as two rival human nobles vie for the regency. As the court infighting escalates, Linden becomes a target of the Fellowship, a secret society of humans who feel that dragonlords should stay out of human politics and who are willing to use black magic to kill the dragonlords if necessary to get their way. Linden is helped in his investigation by his old friend, Bard Otter, and by the ship captain he meets through him, Maurynna, who may be the only one who can help Linden bring Cassori back from the brink of civil war.
# Visage Painting and the Human Face in 20th Century Art

Visage Painting and the Human Face in 20th Century Art was a major international overview of painting and the face held in 2000 at the National Museum of Western Art in Tokyo and at the National Museum of Modern Art, Kyoto, curated by National Museum of Modern Art, Tokyo.
It included works by:
| Magdalena Abakanowicz Ai-mitsu Shigeru Aoki Jean Arp Antonin Artaud Francis Bacon Georg Baselitz Francesco Clemente Chuck Close Jean Dubuffet Max Ernst Fang Lijun Lucio Fontana Tsuguharu Foujita Alberto Giacometti | Toshiyuki Hasegawa Tatsuo Ikeda Leiko Ikemura Alexei von Jawlenski Hitoshi Karasawa On Kawara Myoung Sook Kim Tamiji Kitagawa Paul Klee Oskar Kokoschka Willem de Kooning Yasuo Kuniyoshi Shigeru Kuriyama Henri Matisse Shunsuke Matsumoto | Henri Michaux Tomio Miki Joan Miró Amedeo Modigliani Kaita Murayama Tsune Nakamura Pablo Picasso Jackson Pollock Chatchai Puipia Gerhard Richter Aso Saburo Shoji Sekine Georgy Shishkin Yan Pei Ming Tetsugoro Yoruzu Zhang Xiaogang |

## Subjects

This exhibition presented works by 45 artists from the dawn of the 20th century to the present.
# Joe Salem

Joe Salem may refer to:
* Joe Salem (American football) (born 1938), American football coach and former player
* Joe Salem (soccer) (born 1987), American soccer player
* Joe Salem (sport shooter) (born 1960), Lebanese sports shooter
# Walter Hodges (academic)

Walter Hodges D.D. (died 14 January 1757) was an English academic administrator at the University of Oxford.
Hodges was elected Provost (head) of Oriel College, Oxford, on 24 October 1727, a post he held until his death in 1757. During his time as Provost of Oriel College, he was also Vice-Chancellorof Oxford University from 1741 until 1744.
# Pilão Arcado

Pilão Arcado is a municipality in the state of Bahia in the North-East region of Brazil. Pilão Arcado covers 11,731.5 km$^2$ (4,529.6 sq mi), and has a population of 35,175 with a population density of 3 inhabitants per square kilometer.
Pilão Arcado was originally inhabited by indigenous people of the Mocoase and Acoroase ethnic groups. The first Portuguese inhabitants came from the Guerreiro e Bernardo family, both of Portuguese nobility. A chapel named Santo Antônio do Pilão Arcado and a parish of the same name were established in 1771. The municipality fell into violence between 1842 and 1848. War was declared between the families of Militão Plácido de França Antunes and Captain Bernardo José Guerreiro. The conflict ended on August 1, 1848 with the death of the final adult son of the Guerreiro family. Fighting between the families occurred in both Pilão Arcado and nearby Sento Sé.
# Kössen

Kössen is a municipality in the Kitzbühel district in the Austrian state of Tyrol located 24 km north of Kitzbühel as well as 15.50 km north of Sankt Johann in Tirol at the Kitzbühler Ache near the border to Germany.

## Geography

Kössen is located in a broad basin between the Chiemgauer Alps in the north and the Kaiser Mountains in the south of the confluence of Großache river, the Kohlenbach and the Weißenbach.

## Sights

Maria Klobenstein is a pilgrimage church in the community Kössen in Tirol on the border with Bavaria (municipality Schleching).

## Activities

Kössen's topography lends itself to air sports in the summer months. The surrounding mountain massifs create great thermals, which are near-perfect for hang gliding and paragliding flights, whilst the valley-floor makes safe landing-grounds, as it is broad, flat and mostly meadow-land; furthermore, the winter ski-lifts allow equal access to the summits in their off-season, for the new market of air-sports adventurers.
In hang-gliding, Kössen was the inaugural location for both the World Championships, in 1976, and the European Championships, in 1977. The championships were soon coordinated to be run on alternate years, with a European venue on 'even' years and a global venue on 'odd' years. A new venue is chosen each year for both competitions, but it is a mark of the popularity of Kössen as an air-sports venue, that it is the sole centre, to date, that has been used as a return-venue for each competition, in 1980 and in 1985. Para-gliding is also well-established on the Unterberg.

## Neighboring towns

Aschau im Chiemgau, Kirchdorf in Tirol, Reit im Winkl, Schleching, Schwendt, Unterwössen, Waidring, Walchsee
# Zafra altispira

Zafra altispira is a species of sea snail in the family Columbellidae, the dove snails.
# OpenSciEd

OpenSciEd is an American nonprofit organization that creates open source science education materials and curricula for all grades, initially focusing on grades 6-8. OpenSciEd's approach is based on a science storyline, where students build upon their understanding of a topic by asking questions and investigating their answers through various activities. It has been adopted by 10 states. All materials are reviewed by and follow Next Generation Science Standards.

## Participating States

OpenSciEd has been adopted by California, Iowa, Louisiana, Massachusetts, Michigan, New Jersey, New Mexico, Oklahoma, Rhode Island, and Washington. However, because of the difficulty in switching from traditional education, not all districts in states which adopted the new standards use OpenSciEd.

## Funding

OpenSciEd funders include the Bill and Melinda Gates Foundation, the Carnegie Corporation of New York, the Charles and Lynn Schusterman Family Philanthropies and the William and Flora Hewlett Foundation.

## Approach to Education

According to OpenSciEd, traditional education frequently only pays attention to the point of view of experts, and doesn't consider how students view what they are learning. Because of this, many students don't understand why they are learning what they are, and don't connect the various concepts together. OpenSciEd attempts to solve this by creating a science storyline, where questions of phenomena lead to investigations, which link together to give students a good understanding of the topic.
# Pardomima viettealis

Pardomima viettealis is a moth of the family Crambidae. It occurs in La Réunion and Mauritius.
# Hospital Area

Hospital Area is a central district of Thimphu, Bhutan. Located south of the Memorial Chorten, it contains the central roundabout, JDWR Hospital and the Royal Bhutan Police national headquarters. The Gongphel Lam road divides it from Changzamthok district.
# Skirl

Skirl may refer to:
* Skirl (1999), a CD by Jim Pugliese and David Watson
* Skirl Records, an American record label
# Wandolleck's white-lipped tree frog

Wandolleck's white-lipped tree frog (Litoria albolabris) is a species of frog in the subfamily Pelodryadinae. It is endemic to Papua New Guinea. Its natural habitats are subtropical or tropical moist lowland forests and subtropical or tropical dry lowland grassland.
# Zafra bilineata

Zafra bilineata is a species of sea snail in the family Columbellidae, the dove snails.

## Distribution

This marine species occurs off Ambon, Indonesia.
# Paratrochosina

Paratrochosina is a genus of spiders in the family Lycosidae. It was first described in 1960 by Roewer. As of 2017, it contains 3 species.