# HLA-B52

HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products.
B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B*5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B*5101. There are a number of alleles within the B*52 allele group.

## Serotype

Serotypes B52, B5, B51, and B53 recognition of HLA B*5201 gene product :
| B*52 | B52 | B5 | B51 | B53 | Sample |
| allele | % | % | % | % | size (N) |
| *5201 | 84 | 2 | 7 | 1 | 2823 |
| Alleles link-out to IMGT/HLA Databease at EBI ||||||
HLA *5201 frequencies :
| | | freq |
| ref. | Population | (%) |
| | China Yunnan Lisu | 21.7 |
| | China Yunnan Nu | 18.6 |
| | Bulgaria Gipsy | 18.2 |
| | Venezuela Sierra de Perija Yucpa | 12.8 |
| | India Andhra Pradesh Golla | 12.0 |
| | Japan Central | 10.7 |
| | Japan | 10.4 |
| | Georgia Tbilisi Kurds | 10.3 |
| | Mali Bandiagara | 8.3 |
| | South Africa Natal Tamil | 8.2 |
| | Israel Ashk. and Non-Ashk. Jews | 7.3 |
| | India North Hindus | 6.7 |
| | China Beijing | 6.1 |
| | India New Delhi | 6.1 |
| | India Mumbai Marathas | 5.6 |
| | Tunisia Ghannouch | 5.5 |
| | Thailand pop3 | 5.1 |
| | India West Coast Parsis | 5.0 |
| | India North Delhi | 4.9 |
| | Mexico Mestizos | 4.9 |
| | Argentina Toba Rosario | 4.7 |
| | Mexico Zaptotec Oaxaca | 4.5 |
| | USA Hispanic | 4.5 |
| | China Qinghai Hui | 4.1 |
| | China Inner Mongolia | 3.9 |
| | China North Han | 3.8 |
| | Oman | 3.8 |
| | Senegal Niokholo Mandenka | 3.7 |
| | Bulgaria | 3.6 |
| | Thailand | 3.5 |
| | Ivory Coast Akan Adiopodoume | 3.4 |
| | Venezuela Perja Mountain Bari | 3.4 |
| | Italy North pop 1 | 3.3 |
| | Sudanese | 3.3 |
| | Romanian | 3.2 |
| | Singapore Riau Malay | 3.0 |
| | Autonomous Region Tibetans | 2.8 |
| | Russia Tuva pop 2 | 2.8 |
| | South Korea pop 3 | 2.8 |
| | Iran Baloch | 2.5 |
| | Tunisia | 2.5 |
| | Jordan Amman | 2.4 |
| | USA Hawaii Okinawa | 2.4 |
| | Singapore Javanese Indonesians | 2.0 |
| | Spain Eastern Andalusia | 1.8 |
| | Macedonia pop 4 | 1.6 |
| | Uganda Kampala | 1.6 |
| | Belgium | 1.5 |
| | Mexico Guadalajara Mestizos pop2 | 1.5 |
| | Singapore Thai | 1.5 |
| | Brazil | 1.4 |
| | China Yunnan Lisu | 1.4 |
| | Azores Santa Maria and Sao Miguel | 1.3 |
| | France South East | 1.2 |
| | Italy North Pavia | 1.2 |
| | Saudi Arabia Guraiat and Hail | 1.2 |
| | Mexico Chihuahua State Tarahumara | 1.1 |
| | Tunisia Tunis | 1.1 |
| | Israel Arab Druse | 1.0 |
| | Japan Ainu Hokkaido | 1.0 |
| | Portugal Centre | 1.0 |
| | Singapore Chinese | 1.0 |
| | Taiwan Minnan pop 1 | 1.0 |
| | USA Caucasian | 1.0 |
| | Azores Central Islands | 0.9 |
| | China South Han | 0.9 |
| | Macedonia pop 4 | 0.7 |
| | Morocco Nador Metalsa Class I | 0.7 |
| | Georgia Svaneti Svans | 0.6 |
| | Ireland South | 0.6 |
| | Italy Bergamo | 0.6 |

## Alleles

There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance.

## Disease
### In ulcerative colitis

HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan. This form of disease is frequently found with Takayasu's arteritis.

### In Takayasu's arteritis

Takayasu's arteritis appears to have an independent link to B52 associated disease. The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance.