# 2021 Open Montpellier Méditerranée Métropole Hérault – Singles

Varvara Gracheva was the defending champion but chose to compete at Wimbledon instead.
Anhelina Kalinina won the title, defeating Mayar Sherif in the final, 6–2, 6–3.

## Seeds

* Océane Dodin (quarterfinals)
* Mayar Sherif (final)
* Anhelina Kalinina (champion)
* Harmony Tan (second round, retired)
* Maddison Inglis (second round)
* Francesca Di Lorenzo (first round)
* Cristina Bucșa (semifinals)
* Grace Min (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Zheng Qinwen | 1 | 6 | 2 | | | | |
| 3 | Anhelina Kalinina | 6 | 4 | 6 | | | | |
| 3 | Anhelina Kalinina | 6 | 4 | 6 | 3 | Anhelina Kalinina | 6 | 6 |
| | | | | | 2 | Mayar Sherif | 2 | 3 |
| 7 | Cristina Bucșa | 3 | 4 | | 2 | Mayar Sherif | 2 | 3 |
| 2 | Mayar Sherif | 6 | 6 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | O Dodin | 7 | 6 | | | | | | | | | | | | | | | |
| Q | M Yerolymos | 5 | 2 | | 1 | O Dodin | 6 | 2 | 6 | | | | | | | | | |
| Q | D Spiteri | 4 | 6$^4$ | | | I Fetecău | 4 | 6 | 0 | | | | | | | | | |
| | I Fetecău | 6 | 7$^7$ | | | | | | | 1 | O Dodin | 5 | 1 | | | | | |
| Q | Y Morderger | 7 | 6 | | | | | | | | Q Zheng | 7 | 6 | | | | | |
| WC | L Jeanjean | 5 | 4 | | Q | Y Morderger | 3 | 2 | | | | | | | | | | |
| | Q Zheng | 6 | 6 | | | Q Zheng | 6 | 6 | | | | | | | | | | |
| 8 | G Min | 4 | 3 | | | | | | | | | | | | Q Zheng | 1 | 6 | 2 |
| 3 | A Kalinina | 6 | 7 | | | | | | | | | | | 3 | A Kalinina | 6 | 4 | 6 |
| JE | D Parry | 1 | 5 | | 3 | A Kalinina | 6 | 6 | | | | | | | | | | |
| Q | YL Miyazaki | 2 | 6 | 6 | Q | YL Miyazaki | 2 | 2 | | | | | | | | | | |
| SE | E Jacquemot | 6 | 3 | 0 | | | | | | 3 | A Kalinina | 6 | 6 | | | | | |
| | D Seguel | 6 | 4 | 0 | | | | | | | M Di Giuseppe | 2 | 3 | | | | | |
| | M Di Giuseppe | 4 | 6 | 6 | | M Di Giuseppe | 7$^7$ | 6 | | | | | | | | | | |
| PR | Y Yuan | 7$^7$ | 3 | 2 | 5 | M Inglis | 6$^3$ | 1 | | | | | | | | | | |
| 5 | M Inglis | 6$^5$ | 6 | 6 | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | C Bucșa | 6 | 7 | | | | | | | | | | | | | | |
| | A Hesse | 4 | 5 | | 7 | C Bucșa | 7$^7$ | 7$^7$ | | | | | | | | | |
| | E-G Ruse | 6 | 6 | | | E-G Ruse | 6$^2$ | 6$^5$ | | | | | | | | | |
| | Jia Lu | 4 | 2 | | | | | | | 7 | C Bucșa | 6 | 6 | | | | |
| | J Loeb | 7$^7$ | 6$^3$ | 4 | | | | | | Q | S Nahimana | 1 | 2 | | | | |
| Q | S Nahimana | 6$^4$ | 7$^7$ | 6 | Q | S Nahimana | 6 | 1 | | | | | | | | | |
| | U Eikeri | 2 | 1 | | 4 | H Tan | 2 | 0$^r$ | | | | | | | | | |
| 4 | H Tan | 6 | 6 | | | | | | | | | | | 7 | C Bucșa | 3 | 4 |
| 6 | F Di Lorenzo | 1 | 4 | | | | | | | | | | | 2 | M Sherif | 6 | 6 |
| | T Andrianjafitrimo | 6 | 6 | | | T Andrianjafitrimo | 2 | 1 | | | | | | | | | |
| Q | O Selekhmeteva | 6 | 6 | | Q | O Selekhmeteva | 6 | 6 | | | | | | | | | |
| WC | S Djoubri | 3 | 4 | | | | | | | Q | O Selekhmeteva | 3 | 3 | | | | |
| Q | V Ivakhnenko | 6 | 6 | | | | | | | 2 | M Sherif | 6 | 6 | | | | |
| WC | C Monnet | 2 | 4 | | Q | V Ivakhnenko | 6 | 2 | 3 | | | | | | | | |
| Q | G Maristany | 6$^{10}$ | 4 | | 2 | M Sherif | 1 | 6 | 6 | | | | | | | | |
| 2 | M Sherif | 7$^{12}$ | 6 | | | | | | | | | | | | | | |