# 2022 Garden Open – Singles

Juan Manuel Cerúndolo was the defending champion but chose not to defend his title.
Franco Agamenone won the title after defeating Gian Marco Moroni 6–1, 6–4 in the final.

## Seeds

* Quentin Halys (semifinals)
* Jack Draper (second round)
* Flavio Cobolli (semifinals)
* Christopher O'Connell (withdrew)
* Nikola Milojević (first round)
* Manuel Guinard (first round)
* Hugo Grenier (second round)
* Gilles Simon (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final |
| 1 | Quentin Halys | 6$^4$ | 3 | | | |
| | Gian Marco Moroni | 7$^7$ | 6 | | | |
| | Gian Marco Moroni | 7$^7$ | 6 | Gian Marco Moroni | 1 | 4 |
| | | | | Franco Agamenone | 6 | 6 |
| 3 | Flavio Cobolli | 3 | 4 | Franco Agamenone | 6 | 6 |
| | Franco Agamenone | 6 | 6 | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | Q Halys | 7$^{12}$ | 6 | | | | | | | | | | | | | | | |
| | E Couacaud | 6$^{10}$ | 4 | | 1 | Q Halys | 7$^7$ | 6 | | | | | | | | | | |
| Q | M Geerts | 4 | 7$^7$ | 6 | Q | M Geerts | 6$^1$ | 3 | | | | | | | | | | |
| | A Pellegrino | 6 | 6$^5$ | 2 | | | | | | 1 | Q Halys | 4 | 6 | 7$^8$ | | | | |
| Alt | A Kuznetsov | 2 | 1 | | | | | | | | J de Jong | 6 | 4 | 6$^6$ | | | | |
| | J de Jong | 6 | 6 | | | J de Jong | 6 | 3 | 6 | | | | | | | | | |
| WC | M Arnaldi | 2 | 6 | 6 | WC | M Arnaldi | 1 | 6 | 3 | | | | | | | | | |
| 5 | N Milojević | 6 | 4 | 0 | | | | | | | | | | | 1 | Q Halys | 6$^4$ | 3 |
| LL | L Riedi | 3 | 7 | 6 | | | | | | | | | | | | GM Moroni | 7$^7$ | 6 |
| | N Serdarušić | 6 | 5 | 3 | LL | L Riedi | 6 | 3 | 4 | | | | | | | | | |
| Q | E Kırkın | 6 | 7$^7$ | | Q | E Kırkın | 2 | 6 | 6 | | | | | | | | | |
| | C-M Stebe | 4 | 6$^3$ | | | | | | | Q | E Kırkın | 4 | 3 | | | | | |
| | A Giannessi | 6$^5$ | 2$^r$ | | | | | | | | GM Moroni | 6 | 6 | | | | | |
| Q | D Yevseyev | 7$^7$ | 3 | | Q | D Yevseyev | 0 | 1 | | | | | | | | | | |
| | GM Moroni | 6 | 6 | | | GM Moroni | 6 | 6 | | | | | | | | | | |
| 8 | G Simon | 1 | 4 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | H Grenier | 6 | 4 | 6 | | | | | | | | | | | | | | |
| Alt | A Hoang | 3 | 6 | 4 | 7 | H Grenier | 3 | 3 | | | | | | | | | | |
| | A Çelikbilek | 3 | 7 | 4 | Q | K de Schepper | 6 | 6 | | | | | | | | | | |
| Q | K de Schepper | 6 | 5 | 6 | | | | | | Q | K de Schepper | 6 | 6$^5$ | 3 | | | | |
| | T Fabbiano | 7 | 3 | 7 | | | | | | 3 | F Cobolli | 3 | 7$^7$ | 6 | | | | |
| | S Caruso | 5 | 6 | 5 | | T Fabbiano | 4 | 7$^7$ | 2 | | | | | | | | | |
| | B Ćorić | 6 | 3 | 4 | 3 | F Cobolli | 6 | 6$^4$ | 6 | | | | | | | | | |
| 3 | F Cobolli | 4 | 6 | 6 | | | | | | | | | | | 3 | F Cobolli | 3 | 4 |
| 6 | M Guinard | 3 | 2 | | | | | | | | | | | | | F Agamenone | 6 | 6 |
| | F Agamenone | 6 | 6 | | | F Agamenone | 6 | 2 | 7 | | | | | | | | | |
| Q | L Van Assche | 3 | 4 | | Q | J Eysseric | 4 | 6 | 5 | | | | | | | | | |
| Q | J Eysseric | 6 | 6 | | | | | | | | F Agamenone | 7 | 6 | | | | | |
| WC | G Zeppieri | 6 | 6 | | | | | | | WC | G Zeppieri | 5 | 4 | | | | | |
| WC | S Napolitano | 2 | 2 | | WC | G Zeppieri | 6 | 6 | | | | | | | | | | |
| | T Skatov | 2 | 1 | | 2 | J Draper | 1 | 4 | | | | | | | | | | |
| 2 | J Draper | 6 | 6 | | | | | | | | | | | | | | | |