# 2022 Cali Open – Singles

This was the first edition of the tournament. The tournament originated as a quick replacement for the 2022 edition of the Quito Challenger, which was moved to Cali due to political unrest in Quito.
Facundo Mena won the title after defeating Miljan Zekić 6–2, 7–6$^{(7–3)}$ in the final.

## Seeds

* Tomás Barrios Vera (second round)
* Facundo Mena (champion)
* Juan Pablo Ficovich (second round)
* Felipe Meligeni Alves (quarterfinals)
* Francisco Comesaña (first round, retired)
* Gerald Melzer (second round)
* Gonzalo Lama (first round)
* Miljan Zekić (final)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 8 | Miljan Zekić | 7 | 6 | | | | |
| | Nicolás Mejía | 5 | 4 | | | | |
| | Nicolás Mejía | 5 | 4 | 8 | Miljan Zekić | 2 | 6$^3$ |
| | | | | 2 | Facundo Mena | 6 | 7$^7$ |
| | Nicolás Álvarez | 6$^6$ | 4 | 2 | Facundo Mena | 6 | 7$^7$ |
| 2 | Facundo Mena | 7$^8$ | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1/WC | T Barrios Vera | 6 | 7$^7$ | | | | | | | | | | | | | | |
| Alt | M Pervolarakis | 2 | 6$^3$ | | 1/WC | T Barrios Vera | 6 | 2 | 1 | | | | | | | | |
| Q | RA Burruchaga | 6 | 6 | | Q | RA Burruchaga | 4 | 6 | 6 | | | | | | | | |
| | G Villanueva | 1 | 1 | | | | | | | Q | RA Burruchaga | 5 | 2 | | | | |
| | P Krstin | 6 | 6 | | | | | | | 8 | M Zekić | 7 | 6 | | | | |
| Q | N Chappell | 2 | 4 | | | P Krstin | 6 | 6$^8$ | 5 | | | | | | | | |
| | A Kovacevic | 6 | 4 | 1 | 8 | M Zekić | 4 | 7$^{10}$ | 7 | | | | | | | | |
| 8 | M Zekić | 1 | 6 | 6 | | | | | | | | | | 8 | M Zekić | 7 | 6 |
| 3 | JP Ficovich | 6 | 6 | | | | | | | | | | | | N Mejía | 5 | 4 |
| WC | A Urrea | 3 | 1 | | 3 | JP Ficovich | 6$^4$ | 4 | | | | | | | | | |
| Alt | E Zhu | 2 | 2 | | | N Mejía | 7$^7$ | 6 | | | | | | | | | |
| | N Mejía | 6 | 6 | | | | | | | | N Mejía | 6 | 6 | | | | |
| Q | Matías Zukas | 6 | 6 | | | | | | | Q | M Zukas | 1 | 4 | | | | |
| | K Smith | 4 | 2 | | Q | M Zukas | 2 | 6 | 6 | | | | | | | | |
| | J Menezes | 6 | 6 | | | J Menezes | 6 | 4 | 2 | | | | | | | | |
| 7 | G Lama | 4 | 2 | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 5 | F Comesaña | 5 | 0$^r$ | | | | | | | | | | | | | | | |
| | R Quiroz | 7 | 0 | | | R Quiroz | 6 | 3 | 3 | | | | | | | | | |
| | N Álvarez | 7 | 7$^7$ | | | N Álvarez | 4 | 6 | 6 | | | | | | | | | |
| | A Menéndez Maceiras | 5 | 6$^3$ | | | | | | | | N Álvarez | 6$^4$ | 6 | 7$^9$ | | | | |
| Q | Juan Bautista Otegui | 6 | 7$^9$ | | | | | | | 4 | F Meligeni Alves | 7$^7$ | 4 | 6$^7$ | | | | |
| | V Durasovic | 3 | 6$^7$ | | Q | JB Otegui | 6 | 4 | 6$^2$ | | | | | | | | | |
| | M Jaziri | 4 | 0$^r$ | | 4 | F Meligeni Alves | 2 | 6 | 7$^7$ | | | | | | | | | |
| 4 | F Meligeni Alves | 6 | 4 | | | | | | | | | | | | | N Álvarez | 6$^6$ | 4 |
| 6 | G Melzer | 6 | 6 | | | | | | | | | | | | 2 | F Mena | 7$^8$ | 6 |
| WC | Mateo Gómez | 0 | 0 | | 6 | G Melzer | 4 | 2 | | | | | | | | | | |
| Q | Y-s Chung | 6 | 6 | | Q | Y-s Chung | 6 | 6 | | | | | | | | | | |
| Q | M Alves | 4 | 0 | | | | | | | Q | Y-s Chung | 3 | 7 | 6$^4$ | | | | |
| | N Hardt | 6 | 6$^5$ | 3 | | | | | | 2 | F Mena | 6 | 5 | 7$^7$ | | | | |
| | Facundo Juárez | 4 | 7$^7$ | 6 | | F Juárez | 4 | 0 | | | | | | | | | | |
| | G Oliveira | 4 | 4 | | 2 | F Mena | 6 | 6 | | | | | | | | | | |
| 2 | F Mena | 6 | 6 | | | | | | | | | | | | | | | |