# HDAC1

La histona deacetilasa 1 (HDAC1) és un enzim codificat en humans pel gen HDAC1.

## Funció

Les histones tenen un paper crucial en la regulació de la transcripció, en la progressió del cicle cel·lular i en processos de desenvolupament. La acetilació/desacetilació d'histones altera l'estructura del cromosoma, variant així l'accessibilitat dels factors de transcripció a l'ADN. La HDAC1 pertany a la família d'histona deacetilases acuc/alfa i és un dels components del complex histona deacetilasa. Aquesta proteïna interacciona amb la proteïna del retinoblastoma formant un complex que constitueix un element clau en el control de la proliferació cel·lular i la diferenciació cel·lular. Juntament amb la proteïna 2 associada a metàstasi, deacetila a p53 i modula la seva acció sobre la proliferació cel·lular i l'apoptosi.

## Interaccions

La histona deacetilasa 1 ha demostrat ser capaç d'interaccionar amb:
* RAD9A
* DNMT3L
* MTA1
* FKBP3
* CDC20
* CDH1
* HCFC1
* BUB3
* NCOR2
* IKZF1
* Prohibitina
* EVI1
* DDX5
* DNMT3A
* SMAD2
* HDAC2
* MIER1
* SIN3A
* Proteína 6 associada a mort
* Receptor androgènic
* HMG20B
* HUS1
* IFRD1
* MLL
* ING1
* MyoD
* GATA1
* SPEN
* MAD1L1
* Proteïna de la leucèmia promielocítica
* CHD3
* TGIF1
* Proteïna del retinoblastoma-like 2
* Proteïna del retinoblastoma-like 1
* CHD4
* RCOR1
* RBBP7
* RFC1
* Proteïna del retinoblastoma
* RBBP4
* EED
* PHF21A
* SIN3B
* RELA
* NFKB1
* BUB1B
* Mdm2
* SATB1
* HSPA4
* SUV39H1
* BUB1
* MBD2
* ZBTB16
* DDX17
* BCL6
* SUDS3
* SAP30
* Sp1
* MTA2
* PCNA
* CBFA2T3
* TOP2B
* MBD3
* CTBP1
* TOP2A
* EZH2
* COUP-TFII

## Referències

* ↑ «Fàrmacs amb els quals interactuen físicament amb histone deacetylase 1, vegeu/editeu les referències a wikidata».
* 1 2 3 GRCh38: Ensembl release 89: ENSG00000116478 - Ensembl, May 2017
* 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028800 – Ensembl, May 2017
* ↑ «Human PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
* ↑ «Mouse PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
* ↑ Taunton J, Hassig CA, Schreiber SL «A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p». Science, 272, 5260, May 1996, pàg. 408–11. PMID: 8602529.
* ↑ «Entrez Gene: HDAC1 histone deacetylase 1».
* 1 2 Cai, R L; Yan-Neale Y, Cueto M A, Xu H, Cohen D «HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins». J. Biol. Chem. [UNITED STATES], 275, 36, Sep. 2000, pàg. 27909–16. DOI: 10.1074/jbc.M000168200. ISSN: 0021-9258. PMID: 10846170.
* ↑ Aapola, Ulla; Liiv Ingrid, Peterson Pärt «Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity». Nucleic Acids Res. [England], 30, 16, Aug. 2002, pàg. 3602–8. PMID: 12177302.
* ↑ Deplus, Rachel; Brenner Carmen, Burgers Wendy A, Putmans Pascale, Kouzarides Tony, de Launoit Yvan, Fuks François «Dnmt3L is a transcriptional repressor that recruits histone deacetylase». Nucleic Acids Res. [England], 30, 17, Sep. 2002, pàg. 3831–8. PMID: 12202768.
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* ↑ Joshi, Bharat; Ko Danette, Ordonez-Ercan Dalia, Chellappan Srikumar P «A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis». Biochem. Biophys. Res. Commun. [United States], 312, 2, Dec. 2003, pàg. 459–66. ISSN: 0006-291X. PMID: 14637159.
* 1 2 Wang, Sheng; Fusaro Gina, Padmanabhan Jaya, Chellappan Srikumar P «Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression». Oncogene [England], 21, 55, Dec. 2002, pàg. 8388–96. DOI: 10.1038/sj.onc.1205944. ISSN: 0950-9232. PMID: 12466959.
* ↑ Vinatzer, U; Taplick J; Seiser C; Fonatsch C; Wieser R «The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase». Br. J. Haematol. [England], 114, 3, Sep. 2001, pàg. 566–73. ISSN: 0007-1048. PMID: 11552981.
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* 1 2 Wilson, Brian J; Bates Gaynor J, Nicol Samantha M, Gregory David J, Perkins Neil D, Fuller-Pace Frances V «The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner». BMC Mol. Biol. [England], 5, Aug. 2004, pàg. 11. DOI: 10.1186/1471-2199-5-11. PMID: 15298701.
* ↑ Fuks, F; Burgers W A, Godin N, Kasai M, Kouzarides T «Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription». EMBO J. [England], 20, 10, maig. 2001, pàg. 2536–44. DOI: 10.1093/emboj/20.10.2536. ISSN: 0261-4189. PMID: 11350943.
* ↑ Wotton, D; Lo R S, Lee S, Massagué J «A Smad transcriptional correpressor». Cell [UNITED STATES], 97, 1, Apr. 1999, pàg. 29–39. ISSN: 0092-8674. PMID: 10199400.
* 1 2 3 4 Hakimi, Mohamed-Ali; Bochar Daniel A, Chenoweth Josh, Lane William S, Mandel Gail, Shiekhattar Ramin «A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes». Proc. Natl. Acad. Sci. U.S.A. [United States], 99, 11, maig. 2002, pàg. 7420–5. DOI: 10.1073/pnas.112008599. ISSN: 0027-8424. PMID: 12032298.
* ↑ Hakimi, Mohamed-Ali; Dong Yuanshu, Lane William S, Speicher David W, Shiekhattar Ramin «A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes». J. Biol. Chem. [United States], 278, 9, Feb. 2003, pàg. 7234–9. DOI: 10.1074/jbc.M208992200. ISSN: 0021-9258. PMID: 12493763.
* ↑ Fischle, Wolfgang; Dequiedt Franck, Hendzel Michael J, Guenther Matthew G, Lazar Mitchell A, Voelter Wolfgang, Verdin Eric «Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR». Mol. Cell [United States], 9, 1, Jan. 2002, pàg. 45–57. ISSN: 1097-2765. PMID: 11804585.
* 1 2 Johnson, Colin A; White Darren A, Lavender Jayne S, O'Neill Laura P, Turner Bryan M «Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70». J. Biol. Chem. [United States], 277, 11, Mar. 2002, pàg. 9590–7. DOI: 10.1074/jbc.M107942200. ISSN: 0021-9258. PMID: 11777905.
* ↑ Fischle, W; Dequiedt F, Fillion M, Hendzel M J, Voelter W, Verdin E «Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo». J. Biol. Chem. [United States], 276, 38, Sep. 2001, pàg. 35826–35. DOI: 10.1074/jbc.M104935200. ISSN: 0021-9258. PMID: 11466315.
* 1 2 Ashburner, B P; Westerheide S D, Baldwin A S «The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) correpressors HDAC1 and HDAC2 to negatively regulate gene expression». Mol. Cell. Biol. [United States], 21, 20, Oct. 2001, pàg. 7065–77. DOI: 10.1128/MCB.21.20.7065-7077.2001. ISSN: 0270-7306. PMID: 11564889.
* 1 2 3 4 5 6 7 8 9 Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D «Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation». Genes Dev. [UNITED STATES], 13, 15, Aug. 1999, pàg. 1924–35. ISSN: 0890-9369. PMID: 10444591.
* 1 2 3 4 Tong, J K; Hassig C A, Schnitzler G R, Kingston R E, Schreiber S L «Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex». Nature [ENGLAND], 395, 6705, Oct. 1998, pàg. 917–21. DOI: 10.1038/27699. ISSN: 0028-0836. PMID: 9804427.
* 1 2 3 Hassig, C A; Tong J K, Fleischer T C, Owa T, Grable P G, Ayer D E, Schreiber S L «A role for histone deacetylase activity in HDAC1-mediated transcriptional repression». Proc. Natl. Acad. Sci. U.S.A. [UNITED STATES], 95, 7, Mar. 1998, pàg. 3519–24. ISSN: 0027-8424. PMID: 9520398.
* 1 2 3 Zhang, Y; Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D «Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex». Cell [UNITED STATES], 89, 3, maig. 1997, pàg. 357–64. ISSN: 0092-8674. PMID: 9150135.
* 1 2 3 van der Vlag, J; Otte A P «Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation». Nat. Genet. [UNITED STATES], 23, 4, Dec. 1999, pàg. 474–8. DOI: 10.1038/70602. ISSN: 1061-4036. PMID: 10581039.
* ↑ Ding, Zhihu; Gillespie Laura L, Paterno Gary D «Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain». Mol. Cell. Biol. [United States], 23, 1, Jan. 2003, pàg. 250–8. ISSN: 0270-7306. PMID: 12482978.
* 1 2 Zhang, Ying; Dufau Maria L «Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes». J. Steroid Biochem. Mol. Biol. [England], 85, 2-5, Jun. 2003, pàg. 401–14. ISSN: 0960-0760. PMID: 12943729.
* 1 2 Fleischer, Tracey C; Yun Ui Jeong, Ayer Donald E «Identification and characterization of three new components of the mSin3A correpressor complex». Mol. Cell. Biol. [United States], 23, 10, maig. 2003, pàg. 3456–67. ISSN: 0270-7306. PMID: 12724404.
* ↑ Yang, Liu; Mei Qi, Zielinska-Kwiatkowska Anna, Matsui Yoshito, Blackburn Michael L, Benedetti Daniel, Krumm Anton A, Taborsky Gerald J, Chansky Howard A «An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B». Biochem. J. [England], 369, Pt 3, Feb. 2003, pàg. 651–7. DOI: 10.1042/BJ20020854. ISSN: 0264-6021. PMID: 12398767.
* 1 2 3 Grozinger, C M; Hassig C A, Schreiber S L «Three proteins define a class of human histone deacetylases related to yeast Hda1p». Proc. Natl. Acad. Sci. U.S.A. [UNITED STATES], 96, 9, Apr. 1999, pàg. 4868–73. ISSN: 0027-8424. PMID: 10220385.
* ↑ Zhang, Jinsong; Kalkum Markus, Chait Brian T, Roeder Robert G «The N-CoR-HDAC3 nuclear receptor correpressor complex inhibits the JNK pathway through the integral subunit GPS2». Mol. Cell [United States], 9, 3, Mar. 2002, pàg. 611–23. ISSN: 1097-2765. PMID: 11931768.
* 1 2 3 4 You, A; Tong J K, Grozinger C M, Schreiber S L «CoREST is an integral component of the CoREST- human histone deacetylase complex». Proc. Natl. Acad. Sci. U.S.A. [United States], 98, 4, Feb. 2001, pàg. 1454–8. DOI: 10.1073/pnas.98.4.1454. ISSN: 0027-8424. PMID: 11171972.
* 1 2 3 Zhang, Ying; Dufau Maria L «Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex». J. Biol. Chem. [United States], 277, 36, Sep. 2002, pàg. 33431–8. DOI: 10.1074/jbc.M204417200. ISSN: 0021-9258. PMID: 12091390.
* 1 2 3 Yasui, Dag; Miyano Masaru, Cai Shutao, Varga-Weisz Patrick, Kohwi-Shigematsu Terumi «SATB1 targets chromatin remodelling to regulate genes over long distances». Nature [England], 419, 6907, Oct. 2002, pàg. 641–5. DOI: 10.1038/nature01084. ISSN: 0028-0836. PMID: 12374985.
* ↑ Huang, E Y; Zhang J, Miska E A, Guenther M G, Kouzarides T, Lazar M A «Nuclear receptor correpressors partner with class II histone deacetylases in a Sin3-independent repression pathway». Genes Dev. [UNITED STATES], 14, 1, Jan. 2000, pàg. 45–54. ISSN: 0890-9369. PMID: 10640275.
* 1 2 3 4 Kuzmichev, A; Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D «Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)». Mol. Cell. Biol. [United States], 22, 3, Feb. 2002, pàg. 835–48. ISSN: 0270-7306. PMID: 11784859.
* ↑ Li, H; Leo C, Zhu J, Wu X, O'Neil J, Park E J, Chen J D «Sequestration and inhibition of Daxx-mediated transcriptional repression by PML». Mol. Cell. Biol. [UNITED STATES], 20, 5, Mar. 2000, pàg. 1784–96. ISSN: 0270-7306. PMID: 10669754.
* ↑ Gaughan, Luke; Logan Ian R, Cook Susan, Neal David E, Robson Craig N «Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor». J. Biol. Chem. [United States], 277, 29, Jul. 2002, pàg. 25904–13. DOI: 10.1074/jbc.M203423200. ISSN: 0021-9258. PMID: 11994312.
* ↑ Vietor, Ilja; Vadivelu Santhosh K, Wick Nikolaus, Hoffman Robert, Cotten Matt, Seiser Christian, Fialka Irene, Wunderlich Winfried, Haase Astrid, Korinkova Gabriela, Brosch Gerald, Huber Lukas A «TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells». EMBO J. [England], 21, 17, Sep. 2002, pàg. 4621–31. ISSN: 0261-4189. PMID: 12198164.
* ↑ Xia, Zhen-Biao; Anderson Melanie, Diaz Manuel O, Zeleznik-Le Nancy J «MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the correpressor C-terminal-binding protein». Proc. Natl. Acad. Sci. U.S.A. [United States], 100, 14, Jul. 2003, pàg. 8342–7. DOI: 10.1073/pnas.1436338100. ISSN: 0027-8424. PMID: 12829790.
* ↑ Vieyra, Diego; Loewith Robbie, Scott Michelle, Bonnefin Paul, Boisvert Francois-Michel, Cheema Parneet, Pastyryeva Svitlana, Meijer Maria, Johnston Randal N, Bazett-Jones David P, McMahon Steven, Cole Michael D, Young Dallan, Riabowol Karl «Human ING1 proteins differentially regulate histone acetylation». J. Biol. Chem. [United States], 277, 33, Aug. 2002, pàg. 29832–9. DOI: 10.1074/jbc.M200197200. ISSN: 0021-9258. PMID: 12015309.
* 1 2 Puri, P L; Iezzi S, Stiegler P, Chen T T, Schiltz R L, Muscat G E, Giordano A, Kedes L, Wang J Y, Sartorelli V «Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis». Mol. Cell [United States], 8, 4, Oct. 2001, pàg. 885–97. ISSN: 1097-2765. PMID: 11684023.
* ↑ Mal, A; Sturniolo M, Schiltz R L, Ghosh M K, Harter M L «A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program». EMBO J. [England], 20, 7, Apr. 2001, pàg. 1739–53. DOI: 10.1093/emboj/20.7.1739. ISSN: 0261-4189. PMID: 11285237.
* ↑ Watamoto, Kouichi; Towatari Masayuki, Ozawa Yukiyasu, Miyata Yasuhiko, Okamoto Mitsunori, Abe Akihiro, Naoe Tomoki, Saito Hidehiko «Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation». Oncogene [England], 22, 57, Dec. 2003, pàg. 9176–84. DOI: 10.1038/sj.onc.1206902. ISSN: 0950-9232. PMID: 14668799.
* ↑ Shi, Y; Downes M, Xie W, Kao H Y, Ordentlich P, Tsai C C, Hon M, Evans R M «Sharp, an inducible cofactor that integrates nuclear receptor repression and activation». Genes Dev. [United States], 15, 9, maig. 2001, pàg. 1140–51. DOI: 10.1101/gad.871201. ISSN: 0890-9369. PMID: 11331609.
* ↑ Khan, M M; Nomura T, Kim H, Kaul S C, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi P P, Ishii S «Role of PML and PML-RARalpha in Mad-mediated transcriptional repression». Mol. Cell [United States], 7, 6, Jun. 2001, pàg. 1233–43. ISSN: 1097-2765. PMID: 11430826.
* ↑ Wu, W S; Vallian S, Seto E, Yang W M, Edmondson D, Roth S, Chang K S «The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases». Mol. Cell. Biol. [United States], 21, 7, Apr. 2001, pàg. 2259–68. DOI: 10.1128/MCB.21.7.2259-2268.2001. ISSN: 0270-7306. PMID: 11259576.
* 1 2 Melhuish, T A; Wotton D «The interaction of the carboxyl terminus-binding protein with the Smad correpressor TGIF is disrupted by a holoprosencephaly mutation in TGIF». J. Biol. Chem. [UNITED STATES], 275, 50, Dec. 2000, pàg. 39762–6. DOI: 10.1074/jbc.C000416200. ISSN: 0021-9258. PMID: 10995736.
* ↑ Melhuish, T A; Gallo C M, Wotton D «TGIF2 interacts with histone deacetylase 1 and represses transcription». J. Biol. Chem. [United States], 276, 34, Aug. 2001, pàg. 32109–14. DOI: 10.1074/jbc.M103377200. ISSN: 0021-9258. PMID: 11427533.
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* ↑ Bouzahzah, B; Fu M, Iavarone A, Factor V M, Thorgeirsson S S, Pestell R G «Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo». Cancer Res. [UNITED STATES], 60, 16, Aug. 2000, pàg. 4531–7. ISSN: 0008-5472. PMID: 10969803.
* 1 2 Lai, A; Lee J M, Yang W M, DeCaprio J A, Kaelin W G, Seto E, Branton P E «RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins». Mol. Cell. Biol. [UNITED STATES], 19, 10, Oct. 1999, pàg. 6632–41. ISSN: 0270-7306. PMID: 10490602.
* 1 2 3 Ng, H H; Zhang Y, Hendrich B, Johnson C A, Turner B M, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A «MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex». Nat. Genet. [UNITED STATES], 23, 1, Sep. 1999, pàg. 58–61. DOI: 10.1038/12659. ISSN: 1061-4036. PMID: 10471499.
* ↑ Anderson, Lisa A; Perkins Neil D «The large subunit of replication factor C interacts with the histone deacetylase, HDAC1». J. Biol. Chem. [United States], 277, 33, Aug. 2002, pàg. 29550–4. DOI: 10.1074/jbc.M200513200. ISSN: 0021-9258. PMID: 12045192.
* ↑ Dick, F A; Sailhamer E, Dyson N J «Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins». Mol. Cell. Biol. [UNITED STATES], 20, 10, maig. 2000, pàg. 3715–27. ISSN: 0270-7306. PMID: 10779361.
* ↑ Fuks, F; Burgers W A, Brehm A, Hughes-Davies L, Kouzarides T «DNA methyltransferase Dnmt1 associates with histone deacetylase activity». Nat. Genet. [UNITED STATES], 24, 1, Jan. 2000, pàg. 88–91. DOI: 10.1038/71750. ISSN: 1061-4036. PMID: 10615135.
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* ↑ Nicolas, E; Ait-Si-Ali S, Trouche D «The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein». Nucleic Acids Res. [England], 29, 15, Aug. 2001, pàg. 3131–6. PMID: 11470869.
* ↑ Hassig, C A; Fleischer T C, Billin A N, Schreiber S L, Ayer D E «Histone deacetylase activity is required for full transcriptional repression by mSin3A». Cell [UNITED STATES], 89, 3, maig. 1997, pàg. 341–7. ISSN: 0092-8674. PMID: 9150133.
* ↑ Iwase, Shigeki; Januma Aya, Miyamoto Kiyoko, Shono Naomi, Honda Arata, Yanagisawa Junn, Baba Tadashi «Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression». Biochem. Biophys. Res. Commun. [United States], 322, 2, Sep. 2004, pàg. 601–8. DOI: 10.1016/j.bbrc.2004.07.163. ISSN: 0006-291X. PMID: 15325272.
* ↑ Kiernan, Rosemary; Brès Vanessa, Ng Raymond W M, Coudart Marie-Pierre, El Messaoudi Selma, Sardet Claude, Jin Dong-Yan, Emiliani Stephane, Benkirane Monsef «Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65». J. Biol. Chem. [United States], 278, 4, Jan. 2003, pàg. 2758–66. DOI: 10.1074/jbc.M209572200. ISSN: 0021-9258. PMID: 12419806.
* 1 2 Zhong, Haihong; May Michael J, Jimi Eijiro, Ghosh Sankar «The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1». Mol. Cell [United States], 9, 3, Mar. 2002, pàg. 625–36. ISSN: 1097-2765. PMID: 11931769.
* ↑ Ito, Akihiro; Kawaguchi Yoshiharu, Lai Chun-Hsiang, Kovacs Jeffrey J, Higashimoto Yuichiro, Appella Ettore, Yao Tso-Pang «MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation». EMBO J. [England], 21, 22, Nov. 2002, pàg. 6236–45. ISSN: 0261-4189. PMID: 12426395.
* ↑ Vaute, Olivier; Nicolas Estelle, Vandel Laurence, Trouche Didier «Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases». Nucleic Acids Res. [England], 30, 2, Jan. 2002, pàg. 475–81. PMID: 11788710.
* ↑ Brackertz, Marc; Boeke Joern, Zhang Ru, Renkawitz Rainer «Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3». J. Biol. Chem. [United States], 277, 43, Oct. 2002, pàg. 40958–66. DOI: 10.1074/jbc.M207467200. ISSN: 0021-9258. PMID: 12183469.
* ↑ Chauchereau, Anne; Mathieu Marion, de Saintignon Julie, Ferreira Roger, Pritchard Linda L, Mishal Zohair, Dejean Anne, Harel-Bellan Annick «HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF». Oncogene [England], 23, 54, Nov. 2004, pàg. 8777–84. DOI: 10.1038/sj.onc.1208128. ISSN: 0950-9232. PMID: 15467736.
* 1 2 David, G; Alland L, Hong S H, Wong C W, DePinho R A, Dejean A «Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein». Oncogene [ENGLAND], 16, 19, maig. 1998, pàg. 2549–56. DOI: 10.1038/sj.onc.1202043. ISSN: 0950-9232. PMID: 9627120.
* ↑ Wong, C W; Privalsky M L «Components of the SMRT correpressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6». J. Biol. Chem. [UNITED STATES], 273, 42, Oct. 1998, pàg. 27695–702. ISSN: 0021-9258. PMID: 9765306.
* ↑ Deltour, S; Guerardel C; Leprince D «Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B». Proc. Natl. Acad. Sci. U.S.A. [UNITED STATES], 96, 26, Dec. 1999, pàg. 14831–6. ISSN: 0027-8424. PMID: 10611298.
* ↑ Alland, Leila; David Gregory, Shen-Li Hong, Potes Jason, Muhle Rebecca, Lee Hye-Chun, Hou Harry, Chen Ken, DePinho Ronald A «Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase correpressor complex». Mol. Cell. Biol. [United States], 22, 8, Apr. 2002, pàg. 2743–50. ISSN: 0270-7306. PMID: 11909966.
* ↑ Huang, Nu En; Lin Ching Hui, Lin Young Sun, Yu Winston C Y «Modulation of YY1 activity by SAP30». Biochem. Biophys. Res. Commun. [United States], 306, 1, Jun. 2003, pàg. 267–75. ISSN: 0006-291X. PMID: 12788099.
* ↑ Zhang, Y; Sun Z W, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D «SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex». Mol. Cell [UNITED STATES], 1, 7, Jun. 1998, pàg. 1021–31. ISSN: 1097-2765. PMID: 9651585.
* ↑ Swanson, Kurt A; Knoepfler Paul S, Huang Kai, Kang Richard S, Cowley Shaun M, Laherty Carol D, Eisenman Robert N, Radhakrishnan Ishwar «HBP1 and Mad1 repressors bind the Sin3 correpressor PAH2 domain with opposite helical orientations». Nat. Struct. Mol. Biol. [United States], 11, 8, Aug. 2004, pàg. 738–46. DOI: 10.1038/nsmb798. ISSN: 1545-9993. PMID: 15235594.
* ↑ Yochum, G S; Ayer D E «Pf1, a novel PHD zinc finger protein that links the TLE correpressor to the mSin3A-histone deacetylase complex». Mol. Cell. Biol. [United States], 21, 13, Jul. 2001, pàg. 4110–8. DOI: 10.1128/MCB.21.13.4110-4118.2001. ISSN: 0270-7306. PMID: 11390640.
* ↑ Di Padova, Monica; Bruno Tiziana, De Nicola Francesca, Iezzi Simona, D'Angelo Carmen, Gallo Rita, Nicosia Daniela, Corbi Nicoletta, Biroccio Annamaria, Floridi Aristide, Passananti Claudio, Fanciulli Maurizio «Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter». J. Biol. Chem. [United States], 278, 38, Sep. 2003, pàg. 36496–504. DOI: 10.1074/jbc.M306694200. ISSN: 0021-9258. PMID: 12847090.
* ↑ Singh, Jarnail; Murata Kenji, Itahana Yoko, Desprez Pierre-Yves «Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex». Oncogene [England], 21, 12, Mar. 2002, pàg. 1812–22. DOI: 10.1038/sj.onc.1205252. ISSN: 0950-9232. PMID: 11896613.
* ↑ Sun, Jian-Min; Chen Hou Yu, Moniwa Mariko, Litchfield David W, Seto Edward, Davie James R «The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2». J. Biol. Chem. [United States], 277, 39, Sep. 2002, pàg. 35783–6. DOI: 10.1074/jbc.C200378200. ISSN: 0021-9258. PMID: 12176973.
* ↑ Milutinovic, Snezana; Zhuang Qianli, Szyf Moshe «Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification». J. Biol. Chem. [United States], 277, 23, Jun. 2002, pàg. 20974–8. DOI: 10.1074/jbc.M202504200. ISSN: 0021-9258. PMID: 11929879.
* ↑ Hoogeveen, André T; Rossetti Stefano, Stoyanova Violeta, Schonkeren Joris, Fenaroli Angelia, Schiaffonati Luisa, van Unen Leontine, Sacchi Nicoletta «The transcriptional correpressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies». Oncogene [England], 21, 43, Sep. 2002, pàg. 6703–12. DOI: 10.1038/sj.onc.1205882. ISSN: 0950-9232. PMID: 12242670.
* ↑ Amann, J M; Nip J, Strom D K, Lutterbach B, Harada H, Lenny N, Downing J R, Meyers S, Hiebert S W «ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain». Mol. Cell. Biol. [United States], 21, 19, Oct. 2001, pàg. 6470–83. ISSN: 0270-7306. PMID: 11533236.
* 1 2 Tsai, S C; Valkov N, Yang W M, Gump J, Sullivan D, Seto E «Histone deacetylase interacts directly with DNA topoisomerase II». Nat. Genet. [UNITED STATES], 26, 3, Nov. 2000, pàg. 349–53. DOI: 10.1038/81671. ISSN: 1061-4036. PMID: 11062478.
* 1 2 Johnson, C A; Padget K, Austin C A, Turner B M «Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis». J. Biol. Chem. [United States], 276, 7, Feb. 2001, pàg. 4539–42. DOI: 10.1074/jbc.C000824200. ISSN: 0021-9258. PMID: 11136718.
* ↑ Sakai, Hirotaka; Urano Takeshi, Ookata Kayoko, Kim Mi-Hyun, Hirai Yugo, Saito Motoki, Nojima Yoshihisa, Ishikawa Fuyuki «MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase». J. Biol. Chem. [United States], 277, 50, Dec. 2002, pàg. 48714–23. DOI: 10.1074/jbc.M208461200. ISSN: 0021-9258. PMID: 12354758.
* ↑ Saito, Motoki; Ishikawa Fuyuki «The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2». J. Biol. Chem. [United States], 277, 38, Sep. 2002, pàg. 35434–9. DOI: 10.1074/jbc.M203455200. ISSN: 0021-9258. PMID: 12124384.
* ↑ Zhang, C L; McKinsey T A, Lu J R, Olson E N «Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor». J. Biol. Chem. [UNITED STATES], 276, 1, Jan. 2001, pàg. 35–9. DOI: 10.1074/jbc.M007364200. ISSN: 0021-9258. PMID: 11022042.
* ↑ Sundqvist, A; Sollerbrant K; Svensson C «The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex». FEBS Lett. [NETHERLANDS], 429, 2, Jun. 1998, pàg. 183–8. ISSN: 0014-5793. PMID: 9650586.
* ↑ Smirnov, D A; Hou S, Ricciardi R P «Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription». Virology [UNITED STATES], 268, 2, Mar. 2000, pàg. 319–28. DOI: 10.1006/viro.1999.0181. ISSN: 0042-6822. PMID: 10704340.

## Enllaços externs

* «HDAC1» (en anglès). Medical Subject Headings.