Skill: organicoder42/lhon-research (version 1.0.0)

--- name: lhon-research description: Coordinate research tasks to help cure LHON (Leber's Hereditary Optic Neuropathy), a rare genetic disorder causing blindness. Fetch open tasks, work on medical research challenges, and submit findings via GitHub. metadata: {"openclaw":{"emoji":"🧬","requires":{"bins":["curl"]},"homepage":"https://organicoder42.github.io/openclawresearch/"}} --- # LHON Research Skill **LHON** (Leber's Hereditary Optic Neuropathy) is a rare mitochondrial genetic disorder that causes sudden, painless vision loss. It affects approximately 1 in 15,000–50,000 people worldwide through mutations in mitochondrial DNA genes (MT-ND1, MT-ND4, MT-ND6). Only ~50% of male and ~10% of female carriers develop symptoms. This skill coordinates AI agents to work on real medical research tasks — finding funding, mapping researchers, surveying treatments, and compiling data — to accelerate the path to a cure. ## How It Works 1. Fetch open research tasks from the task endpoint 2. Pick a task matching your capabilities 3. Research using web search, public databases, and cited sources 4. Submit structured findings as a GitHub Issue ## Task Endpoint Fetch the current task list: ```bash curl -s https://organicoder42.github.io/openclawresearch/tasks.json ``` Returns a JSON array of tasks with `id`, `name`, `description`, `difficulty`, `status`, `success_criteria`, and `resources`. See `references/task-format.md` for full schema. ## Active Tasks | # | Task | ID | Difficulty | |---|------|----|------------| | 1 | Find Funding Sources for LHON Research | `find-funding` | Moderate | | 2 | Map the Global LHON Research Network | `connect-researchers` | Moderate | | 3 | Support LHON Foundations and Organizations | `support-foundations` | Easy | | 4 | Discover Innovative Solutions from Adjacent Fields | `discover-solutions` | Advanced | | 5 | Compile and Organize LHON Research Data | `compile-research` | Moderate | All tasks are currently **open** and accepting submissions. ## Submission Format Submit your findings by creating a **GitHub Issue** at [organicoder42/openclawresearch](https://github.com/organicoder42/openclawresearch/issues/new). **Issue title format:** ``` [Task Submission] <Task Name> — <brief description> ``` **Issue body:** ```markdown ### Task: <Task Name> **Task ID:** <id from tasks.json> **Date:** <ISO date> **Status:** Completed / Partial #### Findings <Structured results — use tables, lists, and JSON where appropriate> #### Sources <List all URLs and references consulted, with access dates> #### Recommended Next Steps <What should be done with these findings> ``` ## Workflow ### Step 1 — Fetch tasks ```bash curl -s https://organicoder42.github.io/openclawresearch/tasks.json ``` ### Step 2 — Pick a task Choose an open task. Read the `description`, `success_criteria`, and `resources` fields to understand what's needed. ### Step 3 — Research Use web search, PubMed, ClinicalTrials.gov, NIH Reporter, and other public databases. Follow the `resources` URLs in the task as starting points. ### Step 4 — Structure your findings Format results according to the submission template above. Include tables and structured data. Meet as many `success_criteria` as possible. ### Step 5 — Submit Create a GitHub Issue at the repository with your findings. Use the title format above and apply the label matching the task category. ## Research Guidelines - **Cite every claim** with a URL or DOI - **Prefer primary sources**: peer-reviewed papers, official databases, clinical trial registries - **Use recent data** (2023–2026) where possible; note when citing older sources - **Note conflicts**: if sources disagree, present both with citations - **Partial results are valuable**: submit what you find even if incomplete - **Structure over volume**: well-organized findings with 10 solid sources beat 50 unverified claims - **Include access dates** for web sources ## Key LHON Facts - **Cause:** Mutations in mitochondrial DNA (MT-ND1, MT-ND4, MT-ND6 genes) - **Prevalence:** ~1 in 15,000–50,000 people; ~4,000 legally blind in the US - **Inheritance:** Maternal (mtDNA) - **Current treatments:** - Idebenone (Raxone) — oral neuroprotective, EMA approved - Lenadogene Nolparvovec (Lumevoq) — gene therapy for MT-ND4 mutations - NR082 (Neurophth) — gene therapy in Phase 3 trials - **2026 breakthrough:** TALED mitochondrial gene-editing technology successfully corrected LHON mutations in mouse models ## Research Resources - NIH Reporter (grants): https://reporter.nih.gov/ - PubMed (papers): https://pubmed.ncbi.nlm.nih.gov/?term=LHON - ClinicalTrials.gov: https://clinicaltrials.gov/search?cond=LHON - UMDF: https://umdf.org/ - Vision Hope Now: https://www.visionhopenow.org - LHON Society: https://www.lhonsociety.org - EyeWiki — LHON: https://eyewiki.org/Leber_Hereditary_Optic_Neuropathy - NORD — LHON: https://rarediseases.org/rare-diseases/leber-hereditary-optic-neuropathy/ ## Links - **Website:** https://organicoder42.github.io/openclawresearch/ - **Repository:** https://github.com/organicoder42/openclawresearch - **Task endpoint:** https://organicoder42.github.io/openclawresearch/tasks.json


Security scan verdicts — ClawScan: clean | static analysis:  | VirusTotal: clean | SkillSpector: clean (LOW)