NothingMuch/GO-Terms huggingface dataset:
The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates.
substrate-independent telencephalic tangential interneuron migration
The creation of greater cell numbers in the forebrain due to cell division of progenitor cells.
cell proliferation in forebrain
The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.
hypothalamus development
The directed movement of a cell into the hypothalamus region of the forebrain.
hypothalamus cell migration
The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons.
hypothalamic tangential migration using cell-axon interactions
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate.
early neuron differentiation in forebrain
The mitotic division of a basal progenitor giving rise to two neurons.
forebrain ventricular zone progenitor cell division
The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops.
forebrain regionalization
The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast.
forebrain neuroblast division
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain.
forebrain neuron fate commitment
The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.
forebrain neuron differentiation
The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.
forebrain neuron development
The orderly movement of a cell from one site to another at least one of which is located in the forebrain.
forebrain cell migration
The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb.
olfactory bulb interneuron differentiation
The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell.
olfactory bulb interneuron development
The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex.
cerebral cortex GABAergic interneuron differentiation
The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell.
cerebral cortex GABAergic interneuron development
The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.
cerebral cortex neuron differentiation
The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
forebrain astrocyte differentiation
The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain.
commitment of multipotent stem cells to neuronal lineage in forebrain
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
neural tube development
The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons.
somatic motor neuron fate commitment
The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord.
regulation of cell proliferation in dorsal spinal cord
The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity.
cell proliferation in hindbrain ventricular zone
The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere.
cell proliferation in external granule layer
The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
cerebellar granule cell precursor proliferation
The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain.
hindbrain radial glia guided cell migration
The process that modulates the frequency, rate or extent of granule cell precursor proliferation.
regulation of cerebellar granule cell precursor proliferation
The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei.
deep nuclear neuron cell migration
The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem.
brainstem precerebellar neuron precursor migration
The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.
central nervous system neuron differentiation
The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
central nervous system neuron development
Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells.
central nervous system neuron axonogenesis
The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops.
telencephalon regionalization
The differentiation of cells that will contribute to the structure and function of the hypothalamus.
hypothalamus cell differentiation
The orderly movement of cells from one site to another in the subpallium.
subpallium cell migration
The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell.
olfactory lobe development
The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.
neural plate formation
The process of joining together the neural folds at either end of the neural tube.
neuropore closure
The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate.
convergent extension involved in neural plate elongation
The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population.
subpallium cell proliferation in forebrain
The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population.
pallium cell proliferation in forebrain
The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population.
lateral ganglionic eminence cell proliferation
The orderly movement of a cell from one site to another at least one of which is located in the telencephalon.
telencephalon cell migration
The orderly movement of glial cells through the telencephalon.
telencephalon glial cell migration
The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure.
metencephalon development
The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.
corpus callosum development
The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
cell cycle process
One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
cell cycle phase
A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin.
molting cycle process
A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.
hair cycle process
The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.
membrane docking
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
regulation of cell-cell adhesion
A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.
circadian sleep/wake cycle process
A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism.
reproductive process in single-celled organism
A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
digestive system process
The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur.
menstrual cycle phase
The specification and formation of the polarity of a cell along its proximal/distal axis.
establishment of proximal/distal cell polarity
The attachment of a multicellular organism to a substrate or other organism.
multicellular organism adhesion
The attachment of a multicellular organism to a surface or material.
multicellular organism adhesion to substrate
The process in which the anatomical structures of a gland are generated and organized.
gland morphogenesis
The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand.
DNA strand elongation
A process that results in the breakdown of the extracellular matrix.
extracellular matrix disassembly
The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure.
root system development
A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
proteasome accessory complex
Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated channel activity
Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
ligand-gated channel activity
Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.
gated channel activity
Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.
leak channel activity
Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated.
narrow pore channel activity
Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid.
alanine transmembrane transporter activity
Enables the transfer of a macromolecule from one side of a membrane to the other.
macromolecule transmembrane transporter activity
Enables the transfer of a bacteriocin from one side of a membrane to the other.
bacteriocin transmembrane transporter activity
Any process that modulates the frequency, rate or extent of transmembrane transporter activity.
regulation of transmembrane transporter activity
A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.
electron transport chain
The signaling process in which signal transduction is brought to an end rather than being reversibly modulated.
termination of signal transduction
Binding to a major histocompatibility complex.
MHC protein complex binding
Binding to a class I major histocompatibility complex.
MHC class I protein complex binding
Binding to a class Ib major histocompatibility complex.
MHC class Ib protein complex binding
Binding to a class II major histocompatibility complex.
MHC class II protein complex binding
Binding to a major histocompatibility complex class Ib molecules.
MHC class Ib protein binding
The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular.
neuronal signal transduction
The maintenance of established anisotropic intracellular organization or cell growth patterns.
maintenance of cell polarity
The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8.
CCR4-NOT complex
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
myofibril
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
sarcomere
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
lamellipodium
Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle.
contractile actin filament bundle assembly
Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity.
parallel actin filament bundle assembly
Covalent modification of an actin molecule.
actin modification
Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
actin filament-based movement
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
muscle filament sliding
Movement of a vesicle along an actin filament, mediated by motor proteins.
vesicle transport along actin filament
A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cell junction
Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
regulation of mitotic metaphase/anaphase transition
The regulated release of a peptide hormone from a cell.
peptide hormone secretion
The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
insulin secretion
A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species.
plasma membrane light-harvesting complex
Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria.
light-harvesting complex, core complex
Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center.
light-harvesting complex, peripheral complex
The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.
protein repair
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
myeloid cell differentiation
Any process that modulates the frequency, rate or extent of endocytosis.
regulation of endocytosis
The regulated release of vasopressin from secretory granules into the blood.
vasopressin secretion
A carbohydrate rich layer at the outermost periphery of a cell.
glycocalyx
Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.
membrane coat
A membrane coat found on a coated vesicle.
vesicle coat
A clathrin coat found on a vesicle.
clathrin vesicle coat
A membrane coat adaptor complex that links clathrin to a membrane.
clathrin adaptor complex
The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex.
clathrin coat of coated pit
Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.
coated vesicle
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
clathrin-coated vesicle
The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cell differentiation
The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.
pancreatic juice secretion
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
filopodium
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
neuron differentiation
Any process that modulates the frequency, rate or extent of blood coagulation.
regulation of blood coagulation
Combining with an apolipoprotein to initiate a change in cell activity.
apolipoprotein receptor activity
The specification of female sex of an individual organism.
female sex determination
The specification of male sex of an individual organism.
male sex determination
Formation of myofibrils, the repeating units of striated muscle.
myofibril assembly
Modulates the activity of guanylate cyclase.
guanylate cyclase regulator activity
The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid.
lipid modification
Binding to a LRR domain (leucine rich repeats) of a protein.
LRR domain binding
Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
clathrin binding
Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.
maintenance of gastrointestinal epithelium
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
dynein complex
Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase.
protein serine/threonine kinase inhibitor activity
Stops, prevents or reduces the activity of a protein tyrosine kinase.
protein tyrosine kinase inhibitor activity
Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
protein kinase activator activity
Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.
protein tyrosine kinase activator activity
Uptake of cholesterol into the blood by absorption from the small intestine.
intestinal cholesterol absorption
Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption.
regulation of intestinal cholesterol absorption
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cholesterol transport
A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
external encapsulating structure
An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.
cell envelope
The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.
respiratory tube development