NothingMuch/GO-Terms huggingface dataset:
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen.
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound.
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule.
oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule.
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen.
oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound.
oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome.
oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen.
oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP.
oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor.
oxidoreductase activity, acting on peroxide as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP.
oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome.
oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor.
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water.
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor.
oxidoreductase activity, acting on superoxide radicals as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule.
oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP.
oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen.
oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on reduced flavodoxin as donor
Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen.
oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor
Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
transferase activity
Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor).
hydroxymethyl-, formyl- and related transferase activity
Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule.
succinyltransferase activity
Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule.
N-succinyltransferase activity
Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule.
O-succinyltransferase activity
Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule.
S-succinyltransferase activity
Catalysis of the transfer of a sinapoyl group to an acceptor molecule.
sinapoyltransferase activity
Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule.
O-sinapoyltransferase activity
Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
transferase activity, transferring phosphorus-containing groups
Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).
phosphotransferase activity, alcohol group as acceptor
Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor).
phosphotransferase activity, carboxyl group as acceptor
Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor).
phosphotransferase activity, nitrogenous group as acceptor
Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor).
phosphotransferase activity, phosphate group as acceptor
Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor).
diphosphotransferase activity
Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
nucleotidyltransferase activity
Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor).
phosphotransferase activity, for other substituted phosphate groups
Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors.
phosphotransferase activity, paired acceptors
Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor).
transferase activity, transferring sulphur-containing groups
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
hydrolase activity
Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group.
triphosphoric monoester hydrolase activity
Catalysis of the hydrolysis of a diphosphoester, releasing a diphosphate and a free hydroxyl group.
diphosphoric monoester hydrolase activity
Catalysis of the hydrolysis of a phosphoric triester.
phosphoric triester hydrolase activity
Catalysis of the hydrolysis of any N-glycosyl bond.
hydrolase activity, hydrolyzing N-glycosyl compounds
Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively.
hydrolase activity, acting on ether bonds
Catalysis of the hydrolysis of an ether bond, -O-.
ether hydrolase activity
Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles
Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Catalysis of the hydrolysis of any acid carbon-carbon bond.
hydrolase activity, acting on acid carbon-carbon bonds
Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group.
hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
Catalysis of the hydrolysis of any acid halide bond.
hydrolase activity, acting on acid halide bonds
Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond.
hydrolase activity, acting on acid phosphorus-nitrogen bonds
Catalysis of the hydrolysis of any acid carbon-phosphorus bond.
hydrolase activity, acting on acid carbon-phosphorus bonds
Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
lyase activity
Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.
hydro-lyase activity
Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide.
carbon-oxygen lyase activity, acting on polysaccharides
Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate.
carbon-oxygen lyase activity, acting on phosphates
Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate.
ammonia-lyase activity
Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate.
amidine-lyase activity
Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate.
amine-lyase activity
Catalysis of the breakage of a bond between carbon and any halogen atom.
carbon-halide lyase activity
Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
phosphorus-oxygen lyase activity
Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid.
racemase and epimerase activity, acting on amino acids and derivatives
Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule.
racemase and epimerase activity, acting on hydroxy acids and derivatives
Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule.
racemase and epimerase activity, acting on carbohydrates and derivatives
Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers.
cis-trans isomerase activity
The catalysis of certain rearrangements of a molecule to break or form a ring.
intramolecular lyase activity
Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
ligase activity, forming carbon-oxygen bonds
Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
acid-thiol ligase activity
Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
cyclo-ligase activity
Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen.
carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
ligase activity, forming carbon-carbon bonds
Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
ligase activity, forming phosphoric ester bonds
Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks.
site-specific endodeoxyribonuclease activity, specific for altered base
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule.
oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule.
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids.
alpha-sialidase activity
The covalent linking of a tetrapyrrole to a protein.
protein-tetrapyrrole linkage
The covalent linkage of bilin and a protein.
protein-bilin linkage
Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments.
myosin I binding
Binding to a U6 small nuclear RNA (U6 snRNA).
U6 snRNA binding
Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate.
purine nucleotide binding
Binds to and modulates the activity of a sodium channel.
sodium channel regulator activity
Binds to and modulates the activity of a chloride channel.
chloride channel regulator activity
Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H.
tRNA dihydrouridine synthase activity
Any process that modulates the frequency, rate or extent of exocytosis.
regulation of exocytosis
Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.
regulation of calcium ion-dependent exocytosis
Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol.
CDP-alcohol phosphatidyltransferase activity
Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
serine hydrolase activity
The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine.
peptidyl-lysine hydroxylation
The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine.
N-terminal peptidyl-methionine acetylation
The glucuronylation of the N-terminal amino acid of proteins.
N-terminal protein amino acid glucuronylation
The methylation of the N-terminal alanine of proteins.
N-terminal peptidyl-alanine methylation
The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine).
peptidyl-histidine methylation
The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative.
peptidyl-lysine methylation
Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule.
peptidyl-lysine N6-myristoyltransferase activity
Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule.
peptidyl-lysine N6-palmitoyltransferase activity
The acetylation of the N-terminal lysine of proteins.
N-terminal peptidyl-lysine acetylation
The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid.
peptidyl-L-amino acid racemization
The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid.
protein polyglycylation
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-serine phosphorylation
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
peptidyl-threonine phosphorylation
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
peptidyl-tyrosine phosphorylation
The formation of a covalent cross-link between a nucleic acid and a protein.
nucleic acid-protein covalent cross-linking
The formation of a covalent cross-link between RNA and a protein.
RNA-protein covalent cross-linking
The formation of a covalent cross-link between or within protein chains.
peptide cross-linking
The alteration of an amino acid residue in a peptide.
peptidyl-amino acid modification
The modification of peptidyl-alanine.
peptidyl-alanine modification
The modification of peptidyl-arginine.
peptidyl-arginine modification
The modification of peptidyl-aspartic acid.
peptidyl-aspartic acid modification
The modification of peptidyl-cysteine.
peptidyl-cysteine modification
The modification of peptidyl-glutamine.
peptidyl-glutamine modification
The modification of peptidyl-glutamic acid.
peptidyl-glutamic acid modification
The modification of peptidyl-glycine.
peptidyl-glycine modification
The modification of peptidyl-histidine.
peptidyl-histidine modification
The modification of peptidyl-lysine.
peptidyl-lysine modification
The modification of peptidyl-methionine.
peptidyl-methionine modification
The modification of peptidyl-phenylalanine.
peptidyl-phenylalanine modification
The modification of peptidyl-proline.
peptidyl-proline modification
The modification of peptidyl-serine.
peptidyl-serine modification
The modification of peptidyl-threonine.
peptidyl-threonine modification
The chemical alteration of a tryptophan residue in a peptide.
peptidyl-tryptophan modification
The modification of peptidyl-tyrosine.
peptidyl-tyrosine modification
The addition of a methyl group to an arginine residue in a protein.
peptidyl-arginine methylation
The phosphorylation of peptidyl-aspartic acid.
peptidyl-aspartic acid phosphorylation
The formation of a linkage between a protein amino acid and coenzyme A.
protein-coenzyme A linkage
The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon.
isopeptide cross-linking
The formation of a linkage between a protein amino acid and pyridoxal-5-phosphate.
protein-pyridoxal-5-phosphate linkage
The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid.
chiral amino acid racemization
The addition of an acetyl group to a non-terminal lysine residue in a protein.
internal peptidyl-lysine acetylation
The acetylation of peptidyl-lysine.
peptidyl-lysine acetylation
Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O.
3-hydroxyacyl-CoA dehydratase activity
Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate).
carbon phosphorus lyase activity
Synthesis and ordering of the envelope of pronuclei.
pronuclear envelope synthesis
The determination of sex and sexual phenotype in an organism's germ line.
germ-line sex determination
The determination of sex and sexual phenotypes in an organism's soma.
somatic sex determination
Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate.
guanyl nucleotide binding
The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres.
viral capsid
Any process required for latent viral replication in a cell.
latent virus replication
The process by which a virus begins to replicate following a latency replication decision (switch).
release from viral latency