NothingMuch/GO-Terms huggingface dataset:
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in).
monocarboxylate:sodium symporter activity
The directed movement of a polyamine from outside of a cell, across the plasma membrane and into the cytosol.
polyamine import across plasma membrane
The directed movement of an oligopeptide from outside of a cell, across the plasma membrane and into the cytosol.
oligopeptide import across plasma membrane
The directed movement of a tripeptide from outside of a cell, across the plasma membrane and into the cytosol.
tripeptide import across plasma membrane
Any process that modulates the frequency, rate or extent of long-chain fatty acid import into a cell.
regulation of long-chain fatty acid import into cell
Any process that stops, prevents or reduces the frequency, rate or extent of long-chain fatty acid import into a cell.
negative regulation of long-chain fatty acid import into cell
Any process that activates or increases the frequency, rate or extent of long-chain fatty acid import into a cell.
positive regulation of long-chain fatty acid import into cell
Any process that modulates the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.
regulation of D-aspartate import across plasma membrane
Translation that occurs at the presynapse.
translation at presynapse
A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
presynaptic endocytosis
A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
postsynaptic endocytosis
Translation that occurs at the synapse.
translation at synapse
Any process that regulates translation occurring at the synapse.
regulation of translation at synapse
Any process that regulates translation occurring at the presynapse.
regulation of translation at presynapse
Any process that regulates translation occurring at the postsynapse.
regulation of translation at postsynapse
The chemical reactions and pathways resulting in the breakdown of a protein at a synapse.
protein catabolic process at synapse
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse.
regulation protein catabolic process at synapse
Any process that modulates the frequency, rate or extent of cellular response to phosphate starvation.
regulation of cellular response to phosphate starvation
The directed movement of hexose from outside of a cell, across the plasma membrane and into the cytosol.
hexose import across plasma membrane
Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein.
exogenous protein binding
The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following mitotic cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.
mitotic division septum assembly
Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA.
NAD DNA ADP-ribosyltransferase activity
Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation.
general transcription initiation factor binding
Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
molecular sequestering activity
The directed movement of a substance across the outer membrane in cells with two membranes.
export across cell outer membrane
Receiving a signal and transmitting it in a cell to initiate an immune response.
immune receptor activity
Any process that modulates the frequency, rate or extent of mRNA alternative polyadenylation.
regulation of mRNA alternative polyadenylation
A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
effector-mediated modulation of host defenses by symbiont
Any process that modulates the frequency, rate or extent of protein localization to a meiotic spindle pole body.
regulation of protein localization to meiotic spindle pole body
A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop.
chromosome, telomeric repeat region
The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.
cytoplasm protein quality control
Catalysis of the removal of a methyl group from a protein.
protein demethylase activity
The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way.
spindle pole body anchor activity
Binding to a metal ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
metal ion sequestering activity
The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence.
molecular template activity
A cell migration-dependent mechanism for releasing cellular contents.
migracytosis
Any process that stops, prevents, or reduces the frequency, rate or extent of negative regulation of mitotic spindle assembly checkpoint signaling.
negative regulation of mitotic spindle assembly checkpoint signaling
The central region of a mitotic nuclear bridge, distal to the main portions of the daughter nuclei.
mitotic nuclear bridge midzone
The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way.
protein-RNA adaptor activity
The activity of joining two lipid bilayers to form a single membrane.
fusogenic activity
A DNA recombination process that results in the bidirectional exchange of genetic material between highly homologous DNA molecules.
reciprocal homologous recombination
A protein complex that is part of an endoplasmic reticulum.
endoplasmic reticulum protein-containing complex
A protein-containing complex located intracellularly.
intracellular protein-containing complex
Any process that modulates the frequency, rate or extent of melanotic encapsulation of foreign target.
regulation of melanotic encapsulation of foreign target
Any process that modulates the frequency, rate or extent of the synthesis of a piRNA.
regulation of piRNA transcription
Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host.
defense response to symbiont
The removal of a mislocalized protein from a cellular membrane.
extraction of mislocalized protein from membrane
The aggregation, arrangement and bonding together of a set of components to form an inflammasome complex.
canonical inflammasome complex assembly
Catalytic activity that acts to modify a nucleic acid.
catalytic activity, acting on a nucleic acid
Binds to and increases the activity of an endodeoxyribonuclease.
endodeoxyribonuclease activator activity
Any process that modulates the frequency, rate, or extent of production of oxytocin.
regulation of oxytocin production
A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target.
molecular function activator activity
A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target.
molecular function inhibitor activity
Binding to cyclic GMP-AMP (cGAMP) nucleotide.
cyclic GMP-AMP binding
Binding to chromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization, or to enable equal segregation of the nuclear membrane during mitosis.
chromatin-nuclear membrane anchor activity
Binds to and modulates the activity of a nuclease.
nuclease inhibitor activity
The transcription of lncRNAs, non-coding RNAs over 200 nucleotides in length, from a DNA template.
lncRNA transcription
Any process that modulates the frequency, rate or extent of the synthesis of a lncRNA.
regulation of lncRNA transcription
A molecular function that involves direct binding to one of the subunits of a protein-containing complex, thus preventing an interaction with a factor that would promote dissociation of the complex.
protein-containing complex stabilizing activity
Binding to and responding, e.g. by conformational change, to changes in the cellular level of a metal ion.
metal ion sensor activity
Catalysis of the reaction: a phosphorylated histone + H2O = a protein + phosphate.
histone phosphatase activity
Catalysis of the reaction: L-seryl- + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-.
NAD+-protein-serine ADP-ribosyltransferase activity
Catalysis of the reaction: L-glutamyl- + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl- + nicotinamide.
NAD+-protein-glutamate ADP-ribosyltransferase activity
The directed movement of substances from the cytosol into the Golgi apparatus of a cell.
cytosol to Golgi apparatus transport
Catalysis of the reaction: -dithiol + a hydroperoxide = -disulfide + an alcohol + H2O.
thioredoxin-dependent peroxiredoxin activity
Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) = RNA polymerase II large subunit trans-proline (omega=0).
RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity
Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine.
RNA polymerase II C-terminal domain O-GlcNAc transferase activity
A process that modulates the frequency, rate or extent of the transition from the initiation to the elongation phases of transcription by RNA polymerase II.
regulation of promoter clearance from RNA polymerase II promoter
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + monoatomic cation(in) = solute(in) + monoatomic cation(out). Monoatomic cations include H+, Mg2+, Ca2+, etc.
amino acid:monoatomic cation antiporter activity
Catalysis of the transfer of ubiquitin to a histone substrate.
histone ubiquitin ligase activity
The series of molecular signals initiated by the binding of a double-stranded DNA or RNA from another organism to cytosolic cyclic GMP-AMP (cGAMP) synthase (cGAS) that activates innate immune responses through production of the second messenger cGAMP, which activates the adaptor STING.
cGAS/STING signaling pathway
Catalysis of the reaction: R-CH + a halogen + H2O2 = R-C-halogen + H2O.
haloperoxidase activity
Catalysis of the reaction: R-CH + a halogen + oxygen donor = R-C-halogen +H2O.
halogenase activity
The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a secretory vesicle.
zinc ion import into secretory vesicle
The suite of morphological and architectural changes in an organism induced by high ambient temperatures, below the heat-stress range.
thermomorphogenesis
Any process that modulates the frequency, rate or extent of thermomorphogenesis.
regulation of thermomorphogenesis
The aggregation, arrangement and bonding together of a set of components to form the AIM2 inflammasome complex.
AIM2 inflammasome complex assembly
Any process that modulates the frequency, rate or extent of AIM2 inflammasome complex assembly.
regulation of AIM2 inflammasome complex assembly
A cytoplasmic post-transcriptional gene silencing pathway in which piRNAs direct the cleavage of target mRNAs. The target mRNA, often transcribed from a transposable element, is destabilized by the activity of a PIWI class endonuclease within the piRNA-induced silencing complex. This may also be accompanied by mRNA deadenylation and decapping.
piRNA-mediated gene silencing by mRNA destabilization
A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression.
histone modifying activity
Catalysis of the transfer of a phosphate group to a histone H2A.
histone H2A kinase activity
Catalysis of the transfer of a phosphate group to a histone H3.
histone H3 kinase activity
Catalysis of the transfer of a phosphate group to a histone H4.
histone H4 kinase activity
Catalysis of the transfer of a phosphate group to a histone H2B.
histone H2B kinase activity
Catalysis of the transfer of a phosphate group to a histone variant H2AX.
histone H2AX kinase activity
The chemical reactions and pathways performed by an organism resulting in the breakdown of the extracellular matrix of another organism.
disruption of extracellular matrix of another organism
Removal of an acetyl group from a lysine residue in a histone H3.
histone H3K deacetylase activity
Removal of an acetyl group from a lysine residue in a histone H4.
histone H4K deacetylase activity
Catalysis of the removal of a methyl group from a modified lysine residue of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
histone H3 demethylase activity
Catalysis of the transfer of ubiquitin to a histone H2A substrate.
histone H2A ubiquitin ligase activity
Catalysis of the transfer of ubiquitin to a histone H2B substrate.
histone H2B ubiquitin ligase activity
Catalysis of the transfer of ubiquitin to a histone H3 substrate.
histone H3 ubiquitin ligase activity
Catalysis of the transfer of ubiquitin to a histone H4 substrate.
histone H4 ubiquitin ligase activity
Catalysis of the reaction: H2O + histone H3 L-arginyl = histone H3 L-citrullyl + NH4+, resulting in histone H3 citrullination.
histone H3 arginine deiminase activity
Catalysis of the removal of a methyl group from a modified lysine residue of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
histone H4 demethylase activity
The disruption of an anatomical structure of another organism, leading to damage or temporary subversion of that structure.
disruption of anatomical structure in another organism
The disruption of a cell of another organism, leading to damage or temporary subversion of that cell.
disruption of cell in another organism
Binds to and modulates the activity of a methyltransferase.
methyltransferase regulator activity
Binds to and modulates the activity of a transporter.
transporter regulator activity
Binds to and increases the activity of a transporter.
transporter activator activity
Binds to and stops, prevents, or reduces the activity of a transporter.
transporter inhibitor activity
Catalysis of the breakage of a nitrogen-oxygen bond by means other than hydrolysis and oxidation.
nitrogen-oxygen hydrolyase activity
Catalysis of the reaction: a short-chain fatty acyl-CoA + H2O = a short fatty acid + CoA + H+. A short-chain fatty acid has an aliphatic tail of less than 6 carbons.
short-chain fatty acyl-CoA hydrolase activity
A process in which a symbiont moves across a tissue barrier of the host to transports itself across an extracellular cellular matrix barrier or between the cells of a tissue. This involves the temporary or permanent breaching of the tissue barrier.
symbiont-mediated migration across host tissue barrier
Enables the transmembrane transfer of a solute by a channel that opens when calcium ions bind on the intracellular side of the channel complex or one of its constituent parts.
intracellularly calcium-gated channel activity
Any process that modulates the rate, frequency or extent of nitric oxide-cGMP mediated signal transduction.
regulation of nitric oxide-cGMP mediated signal transduction
A process in which a symbiont inhibits or disrupts the host shutoff of host translation, a host response that prevents mRNA in the cell to be translated, to prevent the symbiont from expressing its genes. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated suppression of host-directed shutoff of host translation
Enables the transfer of a glucosinolate across a membrane.
glucosinolate transmembrane transporter activity
A small RNA-based gene silencing process in which Piwi-associated RNAs (piRNAs) guide de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription.
gene silencing by piRNA-directed DNA methylation
The biosynthetic process resulting in the formation of a nucleic acid.
nucleic acid biosynthetic process
The cellular DNA metabolic process resulting in the breakdown of a nucleic acid.
nucleic acid catabolic process
The formation of heterochromatin into a heterochromatin domain by a process mediated by a small interfering siRNA.
siRNA-mediated heterochromatin formation
The dendrite of the dendritic tree that is farthest away from the neuronal cell body (the soma).
distal dendrite
Any process that modulates the frequency, rate or extent of spontaneous synaptic transmission.
regulation of spontaneous synaptic transmission
A protein complex capable of activating an enzyme. Activating subunits may dissociate from the catalytic unit before the enzyme is active.
enzyme activator complex
The process whose specific outcome is the progression of a basal dendrite over time, from its formation to the mature structure.
basal dendrite development
The process in which the anatomical structures of a basal dendrite are generated and organized.
basal dendrite morphogenesis
The process in which the anatomical structures of an apical dendrite are generated and organized.
apical dendrite morphogenesis
The process whose specific outcome is the progression of an apical dendrite over time, from its formation to the mature structure.
apical dendrite development
Any process that modulates the frequency, rate or extent of protein localization to lysosome.
regulation of protein localization to lysosome
The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels.
postsynaptic dense core vesicle exocytosis
Any process that modulates the frequency, rate or extent of deacetylase activity.
regulation of deacetylase activity
Any process that modulates the frequency, rate or extent of arginase activity.
regulation of arginase activity
Any process that modulates the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity.
regulation of protein-glutamine gamma-glutamyltransferase activity
Any process that modulates the frequency, rate or extent of neuroinflammatory response.
regulation of neuroinflammatory response
Any process that activates or increases the frequency, rate or extent of neuroinflammatory response.
positive regulation of neuroinflammatory response
Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.
negative regulation of neuroinflammatory response
A process in which a protein is transported to, or maintained, in a location within a cell-cell junction.
protein localization to cell-cell junction
Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction.
regulation of protein localization to cell-cell junction
Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction.
positive regulation of protein localization to cell-cell junction
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix.
cell-substrate junction organization
Any process that modulates the frequency, rate or extent of cell-substrate junction organization.
regulation of cell-substrate junction organization
Any process that activates or increases the frequency, rate or extent of cell-substrate junction organization.
positive regulation of cell-substrate junction organization
Any process that stops, prevents or reduces the frequency, rate or extent of cell-substrate junction organization.
negative regulation of cell-substrate junction organization
The disaggregation of a cell junction into its constituent components.
cell junction disassembly
The disaggregation of a cell-cell junction into its constituent components.
cell-cell junction disassembly
The appearance of interleukin-34 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
interleukin-34 production
Any process that modulates the frequency, rate or extent of phosphatidylcholine metabolic process.
regulation of phosphatidylcholine metabolic process
Any process that activates or increases the frequency, rate or extent of phosphatidylcholine metabolic process.
positive regulation of phosphatidylcholine metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine metabolic process.
negative regulation of phosphatidylcholine metabolic process
Any process that modulates the frequency, rate or extent of phosphatidylethanolamine metabolic process.
regulation of phosphatidylethanolamine metabolic process
Any process that modulates the frequency, rate or extent of phosphatidylserine metabolic process.
regulation of phosphatidylserine metabolic process
Any process that activates or increases the frequency, rate or extent of phosphatidylserine metabolic process.
positive regulation of phosphatidylserine metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine metabolic process.
negative regulation of phosphatidylserine metabolic process
Any process that modulates the frequency, rate or extent of transport across the blood-brain barrier.
regulation of transport across blood-brain barrier
Any process that activates or increases the frequency, rate or extent of transport across blood-brain barrier.
positive regulation of transport across blood-brain barrier
Any process that stops, prevents or reduces the frequency, rate or extent of transport across blood-brain barrier.
negative regulation of transport across blood-brain barrier
Binding to a protein upon ADP-ribosylation of the target protein.
ADP-D-ribose modification-dependent protein binding
Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl- = (2E)-2-butenoate + L-lysyl-.
protein decrotonylase activity
histone decrotonylase activity
Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl- + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl- + nicotinamide.
NAD-dependent protein decrotonylase activity
NAD-dependent histone decrotonylase activity