NothingMuch/GO-Terms huggingface dataset:
The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell.
ovarian cumulus cell differentiation
The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.
luteal phase
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.
resistance to pathogenic protozoa
response to protozoa
response to protozoon
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
patterning of blood vessels
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
vascular morphogenesis
The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
ganglioside metabolism
The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
ganglioside anabolism
ganglioside biosynthesis
ganglioside formation
ganglioside synthesis
The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes.
globoside metabolism
The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I).
globoside anabolism
globoside biosynthesis
globoside formation
globoside synthesis
A process that results in a parallel arrangement of microtubules.
microtubule bundling
Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
P2 receptor
purinergic receptor activity
purinoceptor
purinoreceptor
Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
G protein chemoattractant receptor activity
G-protein chemoattractant receptor activity
G-protein coupled chemoattractant receptor activity
Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity.
adenylate cyclase inhibiting metabotropic glutamate receptor activity
adenylyl cyclase inhibiting metabotropic glutamate receptor activity
A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
protease-activated receptor activity
proteinase activated receptor activity
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
osteoblast cell differentiation
Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
endogenous peptide receptor activity
exogenous peptide receptor activity
The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
ureteric bud branching
A homeostatic process in which an organism modulates its internal body temperature.
thermoregulation
The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.
pyrexia
An acute behavioral change resulting from a perceived external threat.
behavioural fear response
Binding to a G protein-coupled receptor.
G protein coupled receptor binding
G protein coupled receptor ligand
G-protein coupled receptor binding
G-protein-coupled receptor ligand
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to hypoxic stress
response to intermittent hypoxia
response to lowered oxygen tension
response to sustained hypoxia
Cell migration that is accomplished by extension and retraction of a pseudopodium.
ameboid cell migration
amoeboid cell migration
amoeboidal cell migration
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
acrosomal granule
acrosome
Binds to and increases the activity of an ATP hydrolysis activity.
ATPase stimulator activity
The nucleus of a male germ cell, a reproductive cell in males.
male germ-cell nucleus
The nucleus of the female germ cell, a reproductive cell in females.
female germ-cell nucleus
The formation of the acrosome from the spermatid Golgi.
acrosome formation
The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
long-chain fatty acid metabolism
Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).
translation initiation ternary complex assembly
A homeostatic process involved in the maintenance of a steady state level of glucose within a cell.
cell glucose homeostasis
cellular glucose homeostasis
Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate.
N-acetylneuraminate acetyltransferase activity
The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
histamine metabolism
The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
hydrochloric acid secretion
A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
deuterostomic gastrulation
A gastrulation process in which the initial invagination becomes the mouth and the anus forms second.
protostomic gastrulation
The formation of the endoderm during gastrulation.
endoblast formation
The cell differentiation process that results in commitment of a cell to become part of the mesoderm.
mesoderm cell fate commitment
The cell differentiation process that results in commitment of a cell to become part of the endoderm.
endoderm cell fate commitment
The cell differentiation process that results in commitment of a cell to become part of the ectoderm.
ectoderm cell fate commitment
The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
endoderm cell fate specification
The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
ectoderm cell fate specification
Catalysis of the reaction: an L-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4+.
L-amino-acid:oxygen oxidoreductase (deaminating)
ophio-amino-acid oxidase activity
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
membrane ruffle
The joining of the small ribosomal subunit, ternary complex, and mRNA.
formation of translation pre-initiation complex
translation preinitiation complex assembly
Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
establishment of planar cell polarity
Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
establishment of wing hair orientation
The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.
epithelial polarization
The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments.
oenocyte cell differentiation
The initial developmental process that will lead to the formation of an eye.
optic placode formation
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
insect-type retina morphogenesis
The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster.
optic lobe and Bolwig\'s organ precursor development
optic lobe placode development
optic placode development
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
formation of mesodermal clusters  systematic_synonym
The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.
induction of an organ
The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.
branching morphogenesis
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
neuron chemotaxis
neuron guidance
neuronal migration
The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.
lipid raft assembly
lipid raft formation
membrane raft formation
The clustering and aggregation of a membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity.
lipid raft polarization
membrane polarization
The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.
lymphocyte polarization
The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.
establishment of T lymphocyte polarity
establishment of T-cell polarity
establishment of T-lymphocyte polarity
T cell polarization
T lymphocyte polarization
T-cell polarization
The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
formation of immunological synapse
The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.
immune cell homeostasis
leucocyte homeostasis
The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.
resting T cell proliferation
resting T-cell proliferation
T lymphocyte homeostatic proliferation
T-cell homeostatic proliferation
T-lymphocyte homeostatic proliferation
The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
natural killer cell development
NK cell differentiation
Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
apoptosis of neutrophils
neutrophil apoptosis
neutrophil programmed cell death by apoptosis
programmed cell death of neutrophils by apoptosis
programmed cell death, neutrophils
The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
B lymphocyte homeostasis
B-cell homeostasis
B-lymphocyte homeostasis
Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
apoptosis of B cells
apoptosis of B lymphocytes
apoptosis of B-cells
apoptosis of B-lymphocytes
B cell apoptosis
B cell programmed cell death by apoptosis
B lymphocyte apoptosis
B lymphocyte programmed cell death by apoptosis
B-cell apoptosis
B-cell programmed cell death by apoptosis
B-lymphocyte apoptosis
B-lymphocyte programmed cell death by apoptosis
programmed cell death of B cells by apoptosis
programmed cell death of B lymphocytes by apoptosis
programmed cell death of B-cells by apoptosis
programmed cell death of B-lymphocytes by apoptosis
programmed cell death, B cells
programmed cell death, B lymphocytes
programmed cell death, B-cells
programmed cell death, B-lymphocytes
The expansion of a natural killer cell population by cell division.
NK cell proliferation
Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.
ADCC
antibody dependent cell death
antibody dependent cell killing
antibody-dependent cell death
antibody-dependent cell killing
type VI hypersensitivity
An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors.
type V hypersensitivity
Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response.
down regulation of type IIa hypersensitivity
down-regulation of type IIa hypersensitivity
downregulation of type IIa hypersensitivity
inhibition of type IIa hypersensitivity
Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.
activation of type IIa hypersensitivity
stimulation of type IIa hypersensitivity
up regulation of type IIa hypersensitivity
up-regulation of type IIa hypersensitivity
upregulation of type IIa hypersensitivity
An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation.
delayed hypersensitivity response
delayed-type hypersensitivity
Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity.
regulation of antibody dependent cell death
regulation of antibody dependent cell killing
regulation of antibody-dependent cell death
regulation of antibody-dependent cell killing
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
cytokine biosynthetic process
cytokine metabolic process
cytokine secretion
interferon production
interferon secretion
interleukin production
interleukin secretion
Any process that modulates the frequency, rate, or extent of production of a cytokine.
regulation of cytokine anabolism
regulation of cytokine biosynthesis
regulation of cytokine biosynthetic process
regulation of cytokine formation
regulation of cytokine secretion
regulation of cytokine synthesis
Any process that stops, prevents, or reduces the rate of production of a cytokine.
down regulation of cytokine biosynthetic process
down regulation of cytokine production
down-regulation of cytokine biosynthetic process
down-regulation of cytokine production
downregulation of cytokine biosynthetic process
downregulation of cytokine production
inhibition of cytokine biosynthetic process
inhibition of cytokine production
negative regulation of cytokine anabolism
negative regulation of cytokine biosynthesis
negative regulation of cytokine biosynthetic process
negative regulation of cytokine formation
negative regulation of cytokine secretion
negative regulation of cytokine synthesis
Any process that activates or increases the frequency, rate or extent of production of a cytokine.
activation of cytokine production
positive regulation of cytokine biosynthetic process
positive regulation of cytokine secretion
stimulation of cytokine production
up regulation of cytokine production
up-regulation of cytokine production
upregulation of cytokine production
The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.
5-HT secretion
5-hydroxytryptamine secretion
serotonin release
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
nephrogenesis
The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.
Wolffian body development
The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.
trophectoderm cell differentiation
The proliferation of cells in the trophectoderm.
trophectoderm cell proliferation
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
EMT
epithelial-mesenchymal transition
mesenchymal cell differentiation from epithelial cell
The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
neural tube morphogenesis
neurulation
The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove.
neural groove formation
The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.
late phagosome biosynthesis
late phagosome formation
phagolysosome formation
The process in which a precursor cell type acquires the specialized features of a NK T cell.
natural killer T cell differentiation
natural T cell differentiation
NK T cell development
NK T lymphocyte differentiation
NK T-cell differentiation
NK T-lymphocyte differentiation
NKT cell differentiation
NT cell differentiation
The expansion of a NK T cell population by cell division.
natural killer T cell proliferation
natural T cell proliferation
NK T lymphocyte proliferation
NK T-cell proliferation
NK T-lymphocyte proliferation
NKT cell proliferation
NT cell proliferation
Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
complement cascade, lectin pathway
Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation.
regulation of complement cascade, lectin pathway
Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
polysaccharide receptor activity
The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.
selenium compound metabolism
selenium metabolic process
selenium metabolism
The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
placental development
placentation
The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
fetal placenta development
Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
decidua development
A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
tissue maintenance
A process mediated by a symbiont that results in the death of a host cell by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
cytolysis by organism of host cells
cytolysis by symbiont of host cells
pathogenesis
The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
activation of MAC
activation of TCC
activation of terminal complement complex
activation of the terminal complement cascade
MAC assembly
MAC formation
membrane attack complex assembly
membrane attack complex formation
Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
necrosis
A process mediated by a symbiont that results in the death of a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
killing by symbiont of host cells
pathogenesis