NothingMuch/GO-Terms huggingface dataset:
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
positive regulation of TLR4 signaling pathway
positive regulation of toll-like receptor 4 signalling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 5 signaling pathway.
negative regulation of TLR5 signaling pathway
negative regulation of toll-like receptor 5 signalling pathway
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 5 signaling pathway.
positive regulation of TLR5 signaling pathway
positive regulation of toll-like receptor 5 signalling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 6 signaling pathway.
negative regulation of TLR6 signaling pathway
negative regulation of toll-like receptor 6 signalling pathway
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 6 signaling pathway.
positive regulation of TLR6 signaling pathway
positive regulation of toll-like receptor 6 signalling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway.
negative regulation of TLR7 signaling pathway
negative regulation of toll-like receptor 7 signalling pathway
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway.
positive regulation of TLR7 signaling pathway
positive regulation of toll-like receptor 7 signalling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 8 signaling pathway.
negative regulation of TLR8 signaling pathway
negative regulation of toll-like receptor 8 signalling pathway
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 8 signaling pathway.
positive regulation of TLR8 signaling pathway
positive regulation of toll-like receptor 8 signalling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway.
negative regulation of TLR9 signaling pathway
negative regulation of toll-like receptor 9 signalling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 10 signaling pathway.
negative regulation of TLR10 signaling pathway
negative regulation of toll-like receptor 10 signalling pathway
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 10 signaling pathway.
positive regulation of TLR10 signaling pathway
positive regulation of toll-like receptor 10 signalling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 11 signaling pathway.
negative regulation of TLR11 signaling pathway
negative regulation of toll-like receptor 11 signalling pathway
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 11 signaling pathway.
positive regulation of TLR11 signaling pathway
positive regulation of toll-like receptor 11 signalling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 12 signaling pathway.
negative regulation of TLR12 signaling pathway
negative regulation of toll-like receptor 12 signalling pathway
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 12 signaling pathway.
positive regulation of TLR12 signaling pathway
positive regulation of toll-like receptor 12 signalling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 13 signaling pathway.
negative regulation of TLR13 signaling pathway
negative regulation of toll-like receptor 13 signalling pathway
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 13 signaling pathway.
positive regulation of TLR13 signaling pathway
positive regulation of toll-like receptor 13 signalling pathway
Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm.
very-low-density lipoprotein binding
VLDL binding
The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid.
D-galactonate breakdown
D-galactonate catabolism
D-galactonate degradation
The chemical reactions and pathways resulting in the breakdown of L-galactonate, the anion of L-galactonic acid.
L-galactonate breakdown
L-galactonate catabolism
L-galactonate degradation
Any process that initiates the activity of the inactive enzyme protein kinase A.
protein kinase A activation
Catalysis of the reaction: D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate.
D,D-heptose 1,7-bisphosphate phosphatase activity
Catalysis of the movement of a glycolipid from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP.
ATP-dependent intramembrane glycolipid transporter activity
ATPase-coupled intramembrane glycolipid transporter activity
glycolipid floppase activity (cytosolic to exoplasmic leaflet)
glycolipid-translocating activity
M5GN2-PP-Dol flippase activity
Man(5)GlcNAc(2)-PP-dolichol translocator
Man5GlcNac2-PP-Dol ER flippase activity
The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.
quinolinate breakdown
quinolinate catabolism
quinolinate degradation
The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.
protein hexamer assembly
protein hexamer biosynthesis
protein hexamer biosynthetic process
protein hexamer formation
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high affinity thiamin:hydrogen symporter activity
high-affinity thiamin:hydrogen symporter activity
high-affinity thiamin:proton symporter activity
high-affinity thiamine:hydrogen symporter activity
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions.
cellular response to zinc ion limitation
cellular response to zinc starvation
Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine.
2-aminoethanol transmembrane transporter activity
ethanolamine permease activity
monoethanolamine transmembrane transporter activity
The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine.
2-aminoethanol transport
monoethanolamine transport
The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide.
enkephalin formation
peptide enkephalin formation
peptide enkephalin processing
The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP).
IAPP formation
IAPP processing
islet amyloid peptide formation
islet amyloid peptide processing
islet amyloid polypeptide formation
Binding to one or both of the catalytic subunits of protein kinase A.
PKA catalytic subunit binding
Binding to one or both of the regulatory subunits of protein kinase A.
PKA regulatory subunit binding
protein kinase A anchoring activity
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
negative regulation of gene-specific transcription elongation from RNA polymerase II promoter
negative regulation of RNA elongation from RNA polymerase II promoter
negative regulation of transcription elongation from RNA polymerase II promoter
A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form.
mitochondrial RNA polymerase complex
mitochondrial RNA polymerase holoenzyme complex
Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase.
mitochondrial DNA-binding transcription factor activity
mitochondrial polymerase transcription factor activity
mitochondrial RNA polymerase binding promoter specificity activity
mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity
mitochondrial RNA polymerase promoter specificity activity
mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding
mitochondrial sequence-specific DNA binding transcription factor activity
mitochondrial sequence-specific DNA-binding transcription factor activity
mitochondrial transcription initiation factor activity
sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity
transcription factor activity, mitochondrial proximal promoter sequence-specific binding
transcription factor activity, mitochondrial RNA polymerase core promoter proximal region sequence-specific binding
transcription factor activity, mitochondrial RNA polymerase core promoter sequence-specific DNA binding
Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+.
Chl b reductase activity
chlorophyll b reductase activity
chlorophyllide b reductase activity
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
down regulation of GTPase activity
down regulation of Rab GTPase activity
down regulation of Ras GTPase activity
down regulation of regulation of Ran GTPase activity
down regulation of Rho GTPase activity
down-regulation of GTPase activity
down-regulation of Rab GTPase activity
down-regulation of Ras GTPase activity
down-regulation of regulation of Ran GTPase activity
down-regulation of Rho GTPase activity
downregulation of GTPase activity
downregulation of Rab GTPase activity
downregulation of Ras GTPase activity
downregulation of regulation of Ran GTPase activity
downregulation of Rho GTPase activity
inhibition of GTPase activity
inhibition of Rab GTPase activity
inhibition of Ras GTPase activity
inhibition of regulation of Ran GTPase activity
inhibition of Rho GTPase activity
negative regulation of guanosinetriphosphatase activity
negative regulation of Rab GTPase activity
negative regulation of Ran GTPase activity
negative regulation of Ras GTPase activity
negative regulation of Rho GTPase activity
The process in which the accumulation of misfolded proteins in the endoplasmic reticulum triggers a response that positively regulates autophagy.
autophagy in response to endoplasmic reticulum overload
autophagy in response to ER stress
The chemical reactions and pathways resulting in the formation of the cytokinin 6-isopentenyladenine.
isopentenyl adenine anabolism
isopentenyl adenine biosynthesis
isopentenyl adenine formation
isopentenyl adenine synthesis
isopentenyladenine biosynthetic process
The chemical reactions and pathways resulting in the breakdown of the cytokinin 6-isopentenyladenine.
isopentenyl adenine breakdown
isopentenyl adenine catabolism
isopentenyl adenine degradation
isopentenyladenine catabolic process
The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6--3H-purin-3-yl}butanoic acid.
discadenine anabolism
discadenine biosynthesis
discadenine formation
discadenine synthesis
The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6--3H-purin-3-yl}butanoic acid.
discadenine breakdown
discadenine catabolism
discadenine degradation
A protein complex that is involved in the Cvt pathway. In budding yeast, the Cvt complex consists of multimers of preApe1p.
cytoplasm to vacuole targeting complex
cytoplasm-to-vacuole targeting complex
A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p.
autophagy-specific phosphatidylinositol 3-kinase (PtdIns3K) complex
phosphatidylinositol 3-kinase complex I
PtdIns-3-kinase complex I
A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p.
phosphatidylinositol 3-kinase complex II
PtdIns-3-kinase complex II
The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid.
4-hydroxyquinoline-2-carboxylic acid biosynthetic process
kynurenic acid anabolism
kynurenic acid biosynthesis
kynurenic acid formation
kynurenic acid synthesis
Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate.
ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming) activity  systematic_synonym
Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate.
9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) activity  systematic_synonym
Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate.
9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) activity  systematic_synonym
Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate.
ent-copalyl-diphosphate diphosphate-lyase  activity  systematic_synonym
ent-pimaradiene synthase activity
Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate.
ent-copalyl-diphosphate diphosphate-lyase  activity  systematic_synonym
ent-pimaradiene synthase activity
Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate.
9alpha-copalyl-diphosphate diphosphate-lyase  activity  systematic_synonym
exo-stemodene synthase activity
stemod-13(17)-ene synthase activity
stemodene synthase activity
syn-stemodene synthase activity
The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal.
perception of maltose stimulus
The aggregation, arrangement and bonding together of a set of components to form a sexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis.
sexual spore wall formation
The formation of conidia by the conversion of a pre-existing hypha. An arthrospore is produced by the last cell on a hypha breaking off and dispersing. Usually the walls thicken and the cell(s) separates before swelling of each spore. Sometimes further septa form in each cell prior to disarticulation.
arthroconidium formation
The formation of a spore following the marked enlargement of part of a cell before separation by a septum. Blastospores are a type of asexual spore found in some fungi, most notably the class Glomeromycota.
blastoconidium formation
Catalysis of the reaction: ATP + beta-D-ribosylnicotinate = ADP + H+ + nicotinate beta-D-ribonucleotide.
nicotinic acid riboside kinase
ribosylnicotinic acid kinase
Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.
DNA gyrase activity
DNA-gyrase activity
Binding to an RNA molecule that has assumed an incorrect conformation.
RNA chaperone
Any process that stops, prevents, or reduces the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far.
down regulation of type III interferon production
down-regulation of type III interferon production
downregulation of type III interferon production
inhibition of type III interferon production
negative regulation of type III IFN production
Any process that activates or increases the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far.
activation of type III interferon production
positive regulation of type III IFN production
stimulation of type III interferon production
up regulation of type III interferon production
up-regulation of type III interferon production
upregulation of type III interferon production
Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far.
interferon-lambda binding
Combining with a type III interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Interferon lambda is the only member of the type III interferon found so far.
interferon-lambda receptor activity
Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end.
RNA pyrophosphohydrolase activity
Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam).
NAD salvage pathway
The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside.
nicotinamide riboside salvage pathway
NR salvage pathway
A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver.
very-low-density lipoprotein complex
VLDL complex
VLDL particle
A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver.
LDL complex
LDL particle
low-density lipoprotein complex
A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL).
IDL complex
IDL particle
intermediate-density lipoprotein complex
A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase).
discoidal HDL
nascent HDL
nascent high-density lipoprotein particle
A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT).
mature HDL
mature high-density lipoprotein particle
spherical HDL
The acquisition, loss or modification of a protein or lipid within an intermediate-density lipoprotein particle.
IDL remodeling
IDL remodelling
intermediate-density lipoprotein particle formation
intermediate-density lipoprotein particle remodelling
The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL.
LDL remodeling
LDL remodelling
low-density lipoprotein particle remodelling
small dense LDL formation
small dense low-density lipoprotein particle formation
The process in which a discoidal high-density lipoprotein (HDL) particle acquires additional lipid or protein molecules, and cholesterol in the particle is converted to tightly bound cholesterol esters by the action of phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT), resulting in the formation of a spherical HDL particle.
conversion of discoidal HDL to spherical HDL
discoidal HDL remodeling
discoidal high-density lipoprotein remodeling
The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle.
VLDL assembly
Catalysis of the reaction: 2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde.
4-aminobutanoate:2-oxoglutarate aminotransferase activity
4-aminobutyrate-2-ketoglutarate aminotransferase activity
4-aminobutyrate-2-oxoglutarate aminotransferase activity
4-aminobutyrate-2-oxoglutarate transaminase activity
4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity
GABA-2-oxoglutarate aminotransferase activity
GABA-2-oxoglutarate transaminase activity
GABA-alpha-ketoglutarate aminotransferase activity
GABA-alpha-ketoglutarate transaminase activity
GABA-alpha-ketoglutaric acid transaminase activity
GABA-alpha-oxoglutarate aminotransferase activity
GABA-oxoglutarate aminotransferase activity
GABA-oxoglutarate transaminase activity
gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity
gamma-aminobutyrate-alpha-ketoglutarate transaminase activity
gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity
gamma-aminobutyric acid-2-oxoglutarate transaminase activity
gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity
gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity
Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine. Also converts glyoxylate to glycine.
gamma-aminobutyric acid pyruvate transaminase activity
A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p.
25-30 S subcomplex of 90S preribosome
UTP-B complex
Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur.
alignment of 3\' and 5\' splice sites of nuclear mRNA