NothingMuch/GO-Terms huggingface dataset:
A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.
endomitosis
Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding.
isotropic bud growth
The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell.
axial bud site selection
axial budding
The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell.
bipolar bud site selection
bipolar budding
polar budding
The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
agglutination
The attachment of a neuron to another cell via adhesion molecules.
neuron adhesion
neuronal cell adhesion
The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction.
calcium-independent cell adhesion molecule activity
The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
receptor guanylyl cyclase signalling pathway
Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity.
transmembrane receptor protein tyrosine kinase activation
transmembrane receptor protein tyrosine kinase dimerization
The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell.
signal complex formation
The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor.
EGF breakdown
EGF catabolism
EGF receptor ligand processing
epidermal growth factor breakdown
epidermal growth factor catabolism
epidermal growth factor ligand processing
intracellular EGF processing
receptor-mediated EGF processing
Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.
down regulation of epidermal growth factor receptor activity
down-regulation of epidermal growth factor receptor activity
downregulation of epidermal growth factor receptor activity
EGF receptor downregulation
inhibition of epidermal growth factor receptor activity
negative regulation of EGF receptor activity
negative regulation of EGFR activity
negative regulation of epidermal growth factor receptor activity
The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex.
TGF-beta receptor complex assembly
TGF-beta:type II receptor:type I receptor complex assembly
TGFbeta receptor complex assembly
The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
transmembrane receptor protein tyrosine phosphatase signaling pathway
transmembrane receptor protein tyrosine phosphatase signalling pathway
Any process that initiates the activity of the inactive enzyme adenylate cyclase.
adenylate cyclase activation
adenylate cyclase activator
adenylyl cyclase activation
An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process.
activation of adenylate cyclase activity by dopamine receptor signaling pathway
activation of adenylate cyclase activity by dopamine receptor signalling pathway
dopamine receptor, adenylate cyclase activating pathway
dopamine receptor, adenylyl cyclase activating pathway
An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process.
activation of adenylate cyclase activity by serotonin receptor signalling pathway
serotonin receptor, adenylate cyclase activating pathway
serotonin receptor, adenylyl cyclase activating pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.
adenylate cyclase inhibitor
down regulation of adenylate cyclase activity
down-regulation of adenylate cyclase activity
downregulation of adenylate cyclase activity
inhibition of adenylate cyclase activity
negative regulation of adenylyl cyclase activity
An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor, and ending with the regulation of a downstream cellular process.
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
inhibition of adenylate cyclase activity by G-protein-coupled glutamate receptor signaling pathway
inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway
inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway
metabotropic glutamate receptor, adenylate cyclase inhibiting pathway
metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway
An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor, and ending with the regulation of a downstream cellular process.
inhibition of adenylate cyclase activity by G-protein coupled acetylcholine receptor signaling pathway
inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway
inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway
muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway
muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway
An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process.
inhibition of adenylate cyclase activity by serotonin receptor signaling pathway
inhibition of adenylate cyclase activity by serotonin receptor signalling pathway
serotonin receptor, adenylate cyclase inhibiting pathway
serotonin receptor, adenylyl cyclase inhibiting pathway
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP).
G protein signaling, coupled to cGMP nucleotide second messenger
G protein signalling, coupled to cGMP nucleotide second messenger
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
G-protein signaling, coupled to cGMP nucleotide second messenger
G-protein signalling, coupled to cGMP nucleotide second messenger
GPCR signaling pathway via activation of guanylate cyclase activity
GPCR signaling pathway via cGMP second messenger
guanylate cyclase-activating G-protein coupled receptor signaling pathway
A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway
activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway
activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway
metabotropic glutamate receptor, phospholipase C activating pathway
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
activation of phospholipase C activity by G-protein coupled acetylcholine receptor signaling pathway
activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway
activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway
muscarinic acetylcholine receptor, phospholipase C activating pathway
muscarinic receptor signaling pathway via activation of PLC
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
activation of phospholipase C activity by serotonin receptor signaling pathway
activation of phospholipase C activity by serotonin receptor signalling pathway
serotonin receptor, phospholipase C activating pathway
A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
activation of phospholipase C activity by tachykinin receptor signaling pathway
activation of phospholipase C activity by tachykinin receptor signalling pathway
tachykinin receptor, phospholipase C activating pathway
The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain.
N receptor target transcription factor activation
Notch receptor target transcription factor activation
The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups.
Hedgehog protein processing
hh protein processing
patched ligand processing
The series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system.
osmosensory signalling pathway via Sho1 osmosensor
signal transduction during osmotic stress via Sho1 osmosensor
The series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system. In S.cerevisiae, the osmosensor is the histidine kinase Sln1.
osmolarity sensing via two-component system
osmolarity signaling pathway via two-component system
osmolarity signalling pathway via two-component system
osmosensory signaling pathway via two-component system
osmosensory signalling pathway via two-component system
signal transduction during osmotic stress via two-component system
The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.
activation of NIK activity
positive regulation of NF-kappaB-inducing kinase activity
The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
cytoplasmic NF-kappaB retention
cytoplasmic NF-kappaB sequestration
cytoplasmic NF-kappaB storage
cytoplasmic retention of NF-kappaB
cytoplasmic sequestration of NF-kappaB
cytoplasmic storage of NF-kappaB
maintenance of NF-kappaB location in cytoplasm
The process of synaptic transmission from a neuron to another neuron across a synapse.
nerve-nerve synaptic transmission
The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes).
spermatogonium division
Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern.
Nebenkern formation
The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation.
spermatid nuclear elongation
The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster.
maintenance of oocyte identity
oocyte cell fate determination
The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster.
follicle cell adhesion
ovarian follicle cell adhesion
Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster.
vitelline membrane formation in chorion-containing eggshell
Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster.
maternal determination of dorsal/ventral axis, oocyte, germ-line encoded
maternal specification of dorsal-ventral axis, oocyte, germ-line encoded
maternal specification of dorsoventral axis, oocyte, germ-line encoded
The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster.
establishment of localization of oocyte nucleus during oocyte axis determination
establishment of oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification
establishment of oocyte nucleus localization during oocyte axis determination
establishment of oocyte nucleus localization involved in oocyte dorsal-ventral axis specification
establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination
establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification
establishment of oocyte nucleus localization involved in oocyte dorsoventral axis specification
nucleus positioning in oocyte during oocyte axis determination
oocyte axis determination, establishment of localization of nucleus
oocyte axis determination, establishment of oocyte nucleus localization
oocyte axis determination, establishment of position of nucleus
oocyte axis determination, oocyte nuclear migration
oocyte axis determination, oocyte nucleus migration
oocyte axis determination, positioning of nucleus
oocyte nuclear migration during oocyte axis determination
oocyte nucleus migration during oocyte axis determination
oocyte nucleus migration during oocyte axis specification
oocyte nucleus positioning during oocyte axis determination
Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster.
maternal determination of dorsal/ventral axis, oocyte, soma encoded
maternal specification of dorsal-ventral axis, oocyte, soma encoded
maternal specification of dorsoventral axis, oocyte, soma encoded
Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.
establishment and maintenance of pole plasm protein localization
oocyte pole plasm protein localization
pole plasm protein localisation
Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein.
down regulation of oskar mRNA translation
down-regulation of oskar mRNA translation
downregulation of oskar mRNA translation
inhibition of oskar mRNA translation
The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote.
zygotic determination of dorsal-ventral axis
zygotic determination of dorsal/ventral axis
zygotic determination of dorsoventral axis
The regionalization process in which the area where the ventral midline will form is specified.
determination of anterior border of ventral midline
determination of posterior border of ventral midline
The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo.
anterior compartment pattern specification
The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo.
germ-band retraction
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.
neuroblast cell fate determination
neuroblast identity determination
Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.
down regulation of neuroblast proliferation
down-regulation of neuroblast proliferation
downregulation of neuroblast proliferation
inhibition of neuroblast proliferation
suppression of neuroblast proliferation
The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster.
tracheal cell fate determination
tracheal epithelial cell fate determination
tracheal placode cell fate determination
Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster.
primary tracheal branching
Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster.
secondary tracheal branching
Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster.
terminal branching of trachea, cytoplasmic projection extension
Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment.
dorsal-ventral lineage restriction, imaginal disc
dorsoventral lineage restriction, imaginal disc
The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc.
progression of morphogenetic furrow during compound eye morphogenesis
The process in which the anatomical structures derived from the prothoracic disc are generated and organized. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle.
prothoracic disc metamorphosis
The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing.
apposition of dorsal and ventral wing surfaces
The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.
endoderm cell fate determination
The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut.
visceral mesoderm/endoderm interaction
A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm.
ectoderm/mesoderm interaction
The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.
adult cardiac development
The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen.
arthropod blood cell development
The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged.
gene conversion at mating-type locus, DNA double-strand break formation
gene conversion at mating-type locus, DNA double-strand break processing
gene conversion at mating-type locus, DNA repair synthesis
gene conversion at mating-type locus, termination of copy-synthesis
heteroduplex formation involved in gene conversion at mating-type locus
strand invasion involved in gene conversion at mating-type locus
The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism.
sex determination, somatic/gonadal interaction
The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation.
puparial glue
The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers.
phototransduction, ultraviolet light
phototransduction, ultraviolet radiation
phototransduction, UV light
phototransduction, UV radiation
UV-sensitive opsin
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
adult walking behaviour
The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes.
behavioral response to pattern orientation
behavioural response to pattern orientation
The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance.
chemosensory jump behaviour
jump response to chemical stimulus
The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.
behavioral response to nutritional stimulus, proboscis extension
proboscis extension in response to nutritional stimulus
The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster.
structural constituent of larval cuticle
The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster.
structural constituent of pupal cuticle