NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: H2O + histone H3 L-arginyl (position 17)= histone H3 L-citrullyl (position 17) + NH4+, resulting in histone H3 citrullination at position 17.
H3-R17 citrullination
histone H3-R17 arginine deiminase activity
histone-arginine deiminase activity (H3-R17 specific)
Catalysis of the reaction: H2O + histone H3 L-arginyl (position 26)= histone H3 L-citrullyl (position 26) + NH4+, resulting in histone H3 citrullination at position 26.
H3-R26 citrullination
histone H3-R26 arginine deiminase activity
histone-arginine deiminase activity (H3-R26 specific)
Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX.
gamma-H2AX-S142 kinase activity
histone H2AX-Y142 kinase activity
histone H2AY142 kinase activity
histone kinase activity (H2AX-Y142 specific)
Catalysis of the reaction: H2O + histone H4 L-arginyl (position 3)= histone H4 L-citrullyl (position 3) + NH4+, resulting in histone H4 citrullination at position 3.
H4-R3 citrullination
histone H4-R3 arginine deiminase activity
histone-arginine deiminase activity (H4-R3 specific)
Catalysis of the reaction: H2O + histone H1 L-arginyl (position 54)= histone H1 L-citrullyl (position 54) + NH4+, resulting in histone H1 citrullination at position 54.
H1-R54 citrullination
histone H1-R54 deiminase activity
histone-arginine deiminase activity (H1-R54 specific)
Catalysis of the reaction: H2O + histone 2A L-arginyl (position 3)= histone 2A L-citrullyl (position 3) + NH4+, resulting in histone H2A citrullination at position 3.
H2A-R3 citrullination
histone H2A-R3 arginine deiminase activity
histone-arginine deiminase activity (H2A-R3 specific)
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: orotate(out) + anion (in) = orotate (in) + anion (out).
orotate:anion antiporter activity
orotate:organic anion antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urate(out) + anion (in) = urate (in) + anion (out).
urate:anion antiporter activity
urate:organic anion antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + Na+(out) + Cl-(out)= glycine betaine(in) + Na+(in) + Cl-(in).
sodium/chloride-dependent glycine betaine transporter activity
Catalysis of the transfer of ADP-ribose groups to the serine-6 or an equivalent residue of the N-terminal tail of histone H2B.
NAD+-histone H2B-S6 serine ADP-ribosyltransferase activity
NAD+-histone-serine ADP-ribosyltransferase activity (H2B-S6 specific)
Catalysis of the transfer of ADP-ribose groups to the serine-10 or an equivalent residue of the N-terminal tail of histone H3.
NAD+-histone H3-S10 serine ADP-ribosyltransferase activity
NAD+-histone-serine ADP-ribosyltransferase activity (H3-S10 specific)
A 5'-end triphospho- + H2O = a 5'-end diphospho- + H+ + phosphate.
mRNA 5\'-phosphatase activity
The directed movement of UDP-beta-L-arabinofuranose from the cytosol to the Golgi apparatus of a cell.
cytosol to Golgi apparatus UDP-beta-L-arabinofuranose transport
Catalysis of the transfer of ADP-ribose groups to the glutamate-35 residue of the N-terminal tail of histone H2B (or an equivalent residue).
NAD+-histone H2B-E35 glutamate ADP-ribosyltransferase activity
NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E35 specific)
Catalysis of the reaction: histone H2B-serine (position 36) + ATP = histone H2B-phosphoserine (position 36) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 36 of histone H2B.
histone H2B-S36 kinase activity
histone kinase activity (H2B-S36 specific)
Catalysis of the reaction: 2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O.
peroxidase activity
Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphotyrosine (position 1).
RNA polymerase II C-terminal domain Y1 kinase activity
Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 2).
RNA polymerase II C-terminal domain S2 kinase activity
Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphothreonine (position 4).
RNA polymerase II C-terminal domain T4 kinase activity
Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 5).
RNA polymerase II C-terminal domain S5 kinase activity
Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 7).
RNA polymerase II C-terminal domain S7 kinase activity
Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 3) = RNA polymerase II large subunit trans-proline (omega=0) (position 3).
RNA polymerase II C-terminal domain P3 isomerase activity
Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 6) = RNA polymerase II large subunit trans-proline (omega=0) (position 6).
RNA polymerase II C-terminal domain P6 isomerase activity
Catalysis of the transfer of ADP-ribose groups to the glutamate-2 residue of the N-terminal tail of histone H2B (or an equivalent residue).
NAD+-histone H2B-E2 glutamate ADP-ribosyltransferase activity
NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E2 specific)
A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite.
ATP-dependent H2A.Z histone chaperone activity
H2AZ histone exchange activity
Catalysis of the transfer of a ubiquitin molecule to a histone 2B at the conserved C-terminal lysine (K) residue. The last K residue is at position 119 in fission yeast, 123 in budding yeast, and 120 in mammals.
histone H2B conserved C-terminal lysine ubiquitin ligase activity
histone H2B-K120 ubiquitin ligase activity
histone H2BK120 ubiquitin ligase activity
histone ubiquitin ligase activity (H2B-K120 specific)
Catalysis of the transfer of a ubiquitin molecule to histone 3 at the lysine-14 residue.
histone H3-K14 ubiquitin ligase activity
histone ubiquitin ligase activity (H3-K14 specific)
Catalysis of the reaction: cholesterol + glycyl-L-cysteinyl- + H+ = -C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-.
cholesterol transferase activity
The series of molecular signals initiated by interleukin-19 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL19-mediated signalling pathway
Catalysis of the reaction: histone H3-serine (position 57) + ATP = histone H3-phosphoserine (position 57) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 57 of histone H3.
histone kinase activity (H3-S57 specific)
histone serine kinase activity (H3-S57 specific)
histone-serine kinase activity (H3-S57 specific)
Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-13 residue.
histone ubiquitin ligase activity (H2A-K13 specific)
Catalysis of the reaction: histone H3-threonine (position 45) + ATP = histone H3-phosphothreonine (position 45) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 45 of histone H3.
histone kinase activity (H3-T45 specific)
histone threonine kinase activity (H3-T45 specific)
histone-threonine kinase activity (H3-T45 specific)
Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-15 residue.
histone ubiquitin ligase activity (H2A-K15 specific)
Catalysis of the reaction: H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol.
2\',7-dihydroxy-4\'-methoxyisoflavanol dehydratase activity
2\'-hydroxyisoflavanol 4,2\'-dehydratase activity
7,2\'-dihydroxy-4\'-methoxyisoflavanol dehydratase activity
medicarpan synthase activity
medicarpin synthase activity
Catalysis of the reaction: a (3R,4R)-4,2'-dihydroxyisoflavan + NADP+ = a (3R)-2'-hydroxyisoflavanone + H+ + NADPH.
vestitone reductase activity
A chromatin remodeling process that allows DNA repair enzyme to access genomic DNA and repair DNA lesions.
DNA damage-dependent chromatin remodelling
Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-119 residue.
histone H2A-K119 ubiquitin ligase activity
histone ubiquitin ligase activity (H2A-K119 specific)
Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-127 residue.
histone H2A-K127 ubiquitin ligase activity
histone ubiquitin ligase activity (H2A-K127 specific)
Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-129 residue.
histone H2A-K129 ubiquitin ligase activity
histone ubiquitin ligase activity (H2A-K129 specific)
The series of molecular signals initiated by interleukin-22 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-22-mediated signaling pathway
interleukin-22-mediated signalling pathway
The series of molecular signals initiated by interleukin-20 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-20-mediated signaling pathway
interleukin-20-mediated signalling pathway
Catalysis of the transfer of ADP-ribose groups to the glutamate-18 residue of histone H2B (or an equivalent residue).
NAD+-histone H2B-E18 glutamate ADP-ribosyltransferase activity
NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E18 specific)
Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs).
base-pairing target-directed microRNA suppressor activity
base-pairing target-directed miRNA suppressor activity
miRNA base-pairing repressor activity
miRNA binding involved in posttranscriptional gene silencing
miRNA inhibitor activity
miRNA sponge
The chemical reactions and pathways resulting in the formation of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system.
viridicatumtoxin anabolism
viridicatumtoxin biosynthesis
viridicatumtoxin formation
viridicatumtoxin synthesis
The chemical reactions and pathways resulting in the formation of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels.
paxilline anabolism
paxilline biosynthesis
paxilline formation
paxilline synthesis
The chemical reactions and pathways resulting in the formation of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture.
paraherquonin anabolism
paraherquonin biosynthesis
paraherquonin formation
paraherquonin synthesis
The chemical reactions and pathways resulting in the formation of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin.
PR-toxin anabolism
PR-toxin biosynthesis
PR-toxin formation
PR-toxin synthesis
The chemical reactions and pathways resulting in the formation of andrastin A, a meroterpenoid that exhibits inhibitory activity against ras farnesyltransferase, suggesting that it could have promising antitumor activity.
andrastin A anabolism
andrastin A biosynthesis
andrastin A formation
andrastin A synthesis
The chemical reactions and pathways resulting in the formation of mevastatin , also known as compactin or ML-236B, and which acts as a potent competitive inhibitor of HMG-CoA reductase.
mevastatin anabolism
mevastatin biosynthesis
mevastatin formation
mevastatin synthesis
The chemical reactions and pathways resulting in the formation of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections.
griseofulvin anabolism
griseofulvin biosynthesis
griseofulvin formation
griseofulvin synthesis
The chemical reactions and pathways resulting in the formation of conidiogenone , a diterpene known to induce the conidiation.
conidiogenone anabolism
conidiogenone biosynthesis
conidiogenone formation
conidiogenone synthesis
The directed movement of zinc ions from a cell, into the extracellular region.
zinc ion export from cell
Any process in which a virus activates or increases the frequency, rate or extent of reticulophagy in the host.
activation of host reticulophagy by virus
positive regulation by virus of host reticulophagy
A process in which a symbiont interferes with, inhibits or disrupts a type II interferon-mediated signaling in the host organism. Type II interferon is also known as interferon-gamma.
negative regulation by virus of host type II interferon-mediated signaling pathway
suppression by virus of host type II IFN-mediated signaling pathway
suppression by virus of host type II interferon-mediated signaling pathway
suppression by virus of host type II interferon-mediated signalling pathway
A process in which a symbiont interferes with, inhibits or disrupts a type III interferon-mediated signaling in the host organism. Type III interferon is also known as interferon-lambda.
negative regulation by virus of host type III interferon-mediated signaling pathway
suppression by virus of host type III IFN-mediated signaling pathway
suppression by virus of host type III interferon-mediated signaling pathway
suppression by virus of host type III interferon-mediated signalling pathway
A histone chaperone that carries a H1 histone.
H1 histone carrier activity
A process leading to the generation of a functional small regulatory non-coding RNA derived from a tRNA.
tRNA-derived small RNA processing
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction chloride(in) + 2 hydrogencarbonate(out) + Na+(out) = chloride(out) + 2 hydrogencarbonate(in) + Na+(in).
sodium,hydrogencarbonate:chloride antiporter activity
sodium-dependent chloride/bicarbonate exchanger activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + amino acid(out) + Na+(out) = H+(out) + amino acid(in) + Na+(in).
amino acid-coupled Na+/H+ exchanger activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-asparagine(out) + Na+(out) = L-asparagine(in) + Na+(in).
asparagine:sodium symporter activity
sodium:asparagine symporter activity
sodium:L-asparagine symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamine(out) + Na+(out) = L-glutamine(in) + Na+(in).
glutamine:sodium symporter activity
sodium:glutamine symporter activity
sodium:L-glutamine symporter activity
Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 26) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 26). This reaction is the addition of a methyl group to the arginine residue at position 26 of histone H3.
histone H3R26 arginine methyltransferase activity
histone methylase activity (H3-R26 specific)
histone methyltransferase activity (H3-R26 specific)
histone-arginine N-methyltransferase activity (H3-R26 specific)
histone-H3R26 methyltransferase activity
Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 122) = CoA + histone H3 N6-acetyl-L-lysine (position 122).
histone acetylase activity (H3-K122 specific)
histone acetyltransferase activity (H3-K122 specific)
histone H3-K122 acetyltransferase activity
histone lysine N-acetyltransferase activity (H3-K122 specific)
The process of doubling of the number of maxicircles and minicircles and distribution of the progeny into two daughter networks, which are identical to the parent kinetoplast DNA network.
kDNA replication
kinetoplast DNA synthesis
replication of kinetoplast DNA
An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death.
canonical holin activity
holin activity
pinholin activity
pore forming activity
Binding to a membrane and increasing its permeability. This may lead to cell membrane lysis and cell content release.
antimicrobial peptide
The core region of the centrosome, a layered structure containing proteins, surrounded by the centrosomal corona. The core duplicates once per cell cycle at the G2/M transition when two outer layers form the mitotic spindle poles.
centrosome core
The aggregation, arrangement and bonding together of a set of components to form a magnetosome. Magnetosomes are specialized organelles for magnetic navigation that comprise membrane-enveloped, nano-sized crystals of a magnetic iron mineral; they are formed by a diverse group of magnetotactic bacteria (MTB).
magnetosome formation
A homeostatic process involved in the maintenance of non-mineral tissue, by preventing mineralization of non-skeletal tissue.
inhibition of ectopic tissue mineralization
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) + Cl-(out) = neutral L-amino acid(in) + Na+(in)+ Cl-(in).
neutral amino acid:sodium:chloride symporter activity
Catalysis of the reaction: a 5'-end (N2,N2,N7-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GMP. Can also use (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA as a substrate.
m(7)GpppN m(7)GMP phosphohydrolase activity
m(7)GpppX diphosphatase activity
m(7)GpppX pyrophosphatase activity
Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+.
m(7)GpppN-mRNA hydrolase activity
A histone deubiquitinase that cleaves ubiquitin from the conserved C-terminal lysine residue of a histone H2B protein to which it is conjugated. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals.
histone conserved C-terminal lysine deubiquitination
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein.
histone deacetylase activity (H4-K12 specific)
histone H4-K12 deacetylase activity
histone H4-K12 deacetylation
histone H4K12 deacetylase activity
histone H4K12 deacetylation
Catalysis of the reaction: N(6)-methyl-L-lysyl(20)- + S-adenosyl-L-methionine = H+ + N(6),N(6)-dimethyl-L-lysyl(20)- + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the monomethlyated lysine residue at position 20 of histone H4, producing H4K20me2.
histone H4 methyl lysine(20) N-methyltransferase activity (H4-K20 specific)
histone H4-K20 dimethylation
histone H4K20 dimethylation
histone H4K20me methylase activity
Catalysis of the reaction: L-lysyl9- + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl9- + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me2.
histone H3-K9 dimethylation
histone H3K9 dimethylase activity
histone H3K9 dimethylation
histone H3K9 mono/dimethylase activity
histone lysine N-dimethyltransferase activity (H3-K9 specific)
Catalysis of the reaction: L-lysyl(20)- + 3 S-adenosyl-L-methionine = 3 H+ + N(6),N(6),N(6)-trimethyl-L-lysyl(20)- + 3 S-adenosyl-L-homocysteine. This reaction is the addition of three methyl groups to the lysine residue at position 20 of the histone H4 protein, producing histone H4K20me3.
histone H4K20 trimethylase activity
histone H4K20 trimethylation
histone lysine N-trimethyltransferase activity (H4-K20 specific)
Catalysis of the reaction: L-lysyl20- + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl20- + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 20 of histone H4, producing histone H4K20me.
histone H4-K20 methylation
histone H4K20 methylase activity
histone H4K20 methylation
histone H4K20 monomethylation
histone lysine N-monomethyltransferase activity (H4-K20 specific)
Catalysis of the reaction: L-lysyl4- + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4- + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me.
histone H3K4 monomethylase activity
histone H4-K4 methylation
histone H4K4 methylation
histone lysine N-monomethyltransferase activity (H3-K4 specific)
Catalysis of the reaction: L-lysyl4- + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl4- + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me2.
histone H3-K4 dimethylation
histone H3K4 dimethylase activity
histone H3K4 dimethylation
histone lysine N-dimethyltransferase activity (H3-K4 specific)
Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9- + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9- + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3.
histone dimethyl-lysine(H3K9) N-methyltransferase activity (H3-K9 specific)
histone H3-K9 trimethylation
histone H3K9 trimethylation
histone H3K9me2 methylase activity
Catalysis of the reaction: L-lysyl9- + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl9- + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me.
histone H3-K9 methylation
histone H3K9 methylation
histone H3K9 monomethylase activity
histone lysine N-monomethyltransferase activity (H3-K9 specific)
Catalysis of the reaction: L-lysyl9- + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl9- + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me3.
histone H3-K9 trimethylation
histone H3K9 mono/di/trimethylase activity
histone H3K9 trimethylase activity
histone H3K9 trimethylation
histone lysine N-trimethyltransferase activity (H3-K9 specific)
A histone deubiquitinase that cleaves ubiquitin from a histone H2A protein to which it is conjugated.
histone H2A deubiquitination
Catalysis of the reaction: L-lysyl27- + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27- + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3.
histone H3-K27 trimethylase activity
histone H3-K27 trimethylation
histone H3K27 mono/di/trimethylase activity
histone H3K27 trimethylase activity
histone H3K27 trimethylation
histone lysine N-trimethyltransferase activity (H3-K27 specific)