NothingMuch/GO-Terms huggingface dataset:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
activation of nitric-oxide synthase 2 biosynthetic process
activation of nitric-oxide synthase biosynthetic process
positive regulation of nitric-oxide synthase (type 2) biosynthesis
positive regulation of nitric-oxide synthase (type 2) biosynthetic process
positive regulation of nitric-oxide synthase (type II) biosynthesis
positive regulation of nitric-oxide synthase (type II) biosynthetic process
positive regulation of nitric-oxide synthase 2 biosynthetic process
positive regulation of NO synthase biosynthesis
positive regulation of NO synthase biosynthetic process
positive regulation of NOS biosynthesis
positive regulation of NOS biosynthetic process
positive regulation of NOS2 synthase biosynthesis
positive regulation of NOS2 synthase biosynthetic process
stimulation of nitric-oxide synthase 2 biosynthetic process
stimulation of nitric-oxide synthase biosynthetic process
up regulation of nitric-oxide synthase 2 biosynthetic process
up regulation of nitric-oxide synthase biosynthetic process
up-regulation of nitric-oxide synthase 2 biosynthetic process
up-regulation of nitric-oxide synthase biosynthetic process
upregulation of nitric-oxide synthase 2 biosynthetic process
upregulation of nitric-oxide synthase biosynthetic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme.
down regulation of nitric-oxide synthase 2 biosynthetic process
down regulation of nitric-oxide synthase biosynthetic process
down-regulation of nitric-oxide synthase 2 biosynthetic process
down-regulation of nitric-oxide synthase biosynthetic process
downregulation of nitric-oxide synthase 2 biosynthetic process
downregulation of nitric-oxide synthase biosynthetic process
inhibition of nitric-oxide synthase 2 biosynthetic process
inhibition of nitric-oxide synthase biosynthetic process
negative regulation of nitric-oxide synthase (type 2) biosynthesis
negative regulation of nitric-oxide synthase (type 2) biosynthetic process
negative regulation of nitric-oxide synthase (type II) biosynthesis
negative regulation of nitric-oxide synthase (type II) biosynthetic process
negative regulation of nitric-oxide synthase 2 biosynthetic process
negative regulation of NO synthase biosynthesis
negative regulation of NO synthase biosynthetic process
negative regulation of NOS biosynthesis
negative regulation of NOS biosynthetic process
negative regulation of NOS2 synthase biosynthesis
negative regulation of NOS2 synthase biosynthetic process
The series of events in which a chemical stimulus indicating redox state is received and converted into a molecular signal. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important.
redox sensing
Catalysis of the reaction:ent-kaur-16-en-19-oate + 3 O2 + 3 reduced  = gibberellin A12 + 4 H+ + 4 H2O + 3 oxidized . Catalyzes three successive oxidations of ent-kaurenoic acid.
ent-kaurenoate oxidase activity
ent-kaurenoic acid oxidase activity
Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction.
(13,14)-all-trans-retinol saturase activity
all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity
all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity
retinol saturase activity
RetSat activity
The chemical reactions and pathways resulting in the formation of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
medium chain fatty acid biosynthesis
medium chain fatty acid biosynthetic process
medium-chain fatty acid anabolism
medium-chain fatty acid biosynthesis
medium-chain fatty acid formation
medium-chain fatty acid synthesis
The chemical reactions and pathways resulting in the breakdown of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
medium chain fatty acid catabolic process
medium chain fatty acid catabolism
medium-chain fatty acid breakdown
medium-chain fatty acid catabolism
medium-chain fatty acid degradation
Any process that activates or increases the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle.
activation of catagen
positive regulation of catagen
stimulation of catagen
up regulation of catagen
up-regulation of catagen
upregulation of catagen
Any process that stops, prevents, or reduces the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle.
down regulation of catagen
down-regulation of catagen
downregulation of catagen
inhibition of catagen
negative regulation of catagen
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
PTEN activity
Any process that stops, prevents, or reduces the frequency, rate or extent of synapse structural plasticity.
down regulation of synapse structural plasticity
down-regulation of synapse structural plasticity
downregulation of synapse structural plasticity
inhibition of synapse structural plasticity
Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity.
activation of synapse structural plasticity
stimulation of synapse structural plasticity
up regulation of synapse structural plasticity
up-regulation of synapse structural plasticity
upregulation of synapse structural plasticity
The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
transport of peptides or proteins into symbiont
The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus.
behavioral process during general adaptation syndrome
behavioral response during general adaptation syndrome
behavioural process during general adaptation syndrome
behavioural response during general adaptation syndrome
general adaptation syndrome, behavioral response
general adaptation syndrome, behavioural process
general adaptation syndrome, behavioural response
Binding to dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms.
DHF binding
dihydrofolate binding
The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
(4E)-sphing-4-enine catabolic process
(4E)-sphing-4-enine catabolism
sphing-4-enine catabolic process
sphing-4-enine catabolism
The chemical reactions and pathways resulting in the breakdown of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol.
dihydrosphingosine-1-phosphate catabolic process
dihydrosphingosine-1-phosphate catabolism
Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
Hsp90 binding
Hsp90 class protein binding
Any process that activates or increases the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle.
activation of anagen
positive regulation of anagen
stimulation of anagen
up regulation of anagen
up-regulation of anagen
upregulation of anagen
Any process that stops, prevents, or reduces the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle.
down regulation of anagen
down-regulation of anagen
downregulation of anagen
inhibition of anagen
negative regulation of anagen
Any process that activates or increases the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle.
activation of exogen
positive regulation of exogen
stimulation of exogen
up regulation of exogen
up-regulation of exogen
upregulation of exogen
Any process that stops, prevents, or reduces the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle.
down regulation of exogen
down-regulation of exogen
downregulation of exogen
inhibition of exogen
negative regulation of exogen
Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
activation of focal adhesion formation
stimulation of focal adhesion formation
up regulation of focal adhesion formation
up-regulation of focal adhesion formation
upregulation of focal adhesion formation
Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
down regulation of focal adhesion formation
down-regulation of focal adhesion formation
downregulation of focal adhesion formation
inhibition of focal adhesion formation
Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction.
activation of protein kinase B signaling cascade
positive regulation of AKT signaling cascade
positive regulation of AKT signalling cascade
positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction
positive regulation of PI3K-PKB/Akt pathway
positive regulation of PI3K/Akt signal transduction
positive regulation of PI3K/PKB signal transduction
positive regulation of PKB signaling cascade
positive regulation of PKB signalling cascade
positive regulation of protein kinase B signaling
positive regulation of protein kinase B signaling cascade
positive regulation of protein kinase B signalling cascade
stimulation of protein kinase B signaling cascade
up regulation of protein kinase B signaling cascade
up-regulation of protein kinase B signaling cascade
upregulation of protein kinase B signaling cascade
Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction.
down regulation of protein kinase B signaling cascade
down-regulation of protein kinase B signaling cascade
downregulation of protein kinase B signaling cascade
inhibition of protein kinase B signaling cascade
negative regulation of AKT signaling cascade
negative regulation of AKT signalling cascade
negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction
negative regulation of PI3K-PKB/Akt pathway
negative regulation of PI3K/Akt signal transduction
negative regulation of PI3K/PKB signal transduction
negative regulation of PKB signaling cascade
negative regulation of PKB signalling cascade
negative regulation of protein kinase B signaling
negative regulation of protein kinase B signaling cascade
negative regulation of protein kinase B signalling cascade
Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.
activation of mitochondrial depolarization
stimulation of mitochondrial depolarization
up regulation of mitochondrial depolarization
up-regulation of mitochondrial depolarization
upregulation of mitochondrial depolarization
Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.
down regulation of mitochondrial depolarization
down-regulation of mitochondrial depolarization
downregulation of mitochondrial depolarization
inhibition of mitochondrial depolarization
Any process in which a pigment granule is maintained in a location and prevented from moving elsewhere.
maintenance of pigment granule localization
Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione.
Gfa
glutathione-dependent formaldehyde-activating enzyme activity
S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)
S-(hydroxymethyl)glutathione formaldehyde-lyase activity
Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule.
double-stranded DNA 5\'-3\' exodeoxyribonuclease activity
double-stranded DNA specific 5\'-3\' exodeoxyribonuclease activity
Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine.
coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity
hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity
methanophenazine hydrogenase activity
methylviologen-reducing hydrogenase activity
Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine.
CoB-CoM heterodisulfide reductase activity
coenzyme B--coenzyme M heterodisulfide reductase activity
coenzyme B:coenzyme M:methanophenazine oxidoreductase activity
coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity
heterodisulfide reductase activity
soluble heterodisulfide reductase activity
The process in which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require.
activation of synaptic plasticity by chemical substance
activation of synaptic plasticity by drug
induction of synaptic plasticity by drug
Binding to granulocyte colony-stimulating factor, G-CSF.
G-CSF binding
granulocyte colony stimulating factor binding
Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
down regulation of fibrinolysis
down-regulation of fibrinolysis
downregulation of fibrinolysis
inhibition of fibrinolysis
Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
activation of fibrinolysis
stimulation of fibrinolysis
up regulation of fibrinolysis
up-regulation of fibrinolysis
upregulation of fibrinolysis
Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H+ + 4 phosphate.
5\'-deoxy-5\'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity
adenosylcobyric acid synthase (glutamine-hydrolysing) activity
adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)
Ado-cobyric acid synthase  activity
CobQ activity
cobyric acid synthase activity
The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle.
4-aminobutyrate import
GABA import
gamma-aminobutyrate import
gamma-aminobutyric acid uptake
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell.
down regulation of glutamate uptake during transmission of nerve impulse
down-regulation of glutamate uptake during transmission of nerve impulse
downregulation of glutamate uptake during transmission of nerve impulse
inhibition of glutamate uptake during transmission of nerve impulse
negative regulation of glutamate reuptake
negative regulation of glutamate uptake during transmission of nerve impulse
negative regulation of glutamate uptake involved in conduction of nerve impulse
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell.
down regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
down-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
downregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
inhibition of gamma-aminobutyric acid uptake during transmission of nerve impulse
negative regulation of 4-aminobutyrate reuptake
negative regulation of 4-aminobutyrate uptake during transmission of nerve impulse
negative regulation of GABA reuptake
negative regulation of GABA uptake during transmission of nerve impulse
negative regulation of gamma-aminobutyric acid reuptake
negative regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
negative regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse
Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell.
activation of gamma-aminobutyric acid uptake during transmission of nerve impulse
positive regulation of 4-aminobutyrate reuptake
positive regulation of 4-aminobutyrate uptake during transmission of nerve impulse
positive regulation of GABA reuptake
positive regulation of GABA uptake during transmission of nerve impulse
positive regulation of gamma-aminobutyric acid reuptake
positive regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
positive regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse
stimulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
up regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
up-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
upregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell.
activation of glutamate uptake during transmission of nerve impulse
positive regulation of glutamate reuptake
positive regulation of glutamate uptake during transmission of nerve impulse
positive regulation of glutamate uptake involved in conduction of nerve impulse
stimulation of glutamate uptake during transmission of nerve impulse
up regulation of glutamate uptake during transmission of nerve impulse
up-regulation of glutamate uptake during transmission of nerve impulse
upregulation of glutamate uptake during transmission of nerve impulse
The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine.
lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate
lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate
Enables the directed movement of lysophospholipids from one side of a membrane to the other. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids.
lysophospholipid transporter activity
The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate.
alginate acetylation
Enables the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other.
Fe-NA chelate transporter activity
Enables the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other.
Cu-NA chelate transporter activity
Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine.
coproporphyrinogen III oxidase activity
coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)
HemN
oxygen-independent coproporphyrinogen-III oxidase activity
radical SAM enzyme activity
Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
D-2-hydroxyglutarate dehydrogenase activity
Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic acid + beta-D-glucose.
ABA-GE beta-glucosidase activity
Catalysis of the reaction: 2 (2E,6E)-farnesyl diphosphate + H+ + NAD(P)H = 2 diphosphate + NAD(P)+ + squalene.
squalene synthetase activity
Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2.
4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxylate decarboxylase activity
OHCU decarboxylase activity
The chemical reactions and pathways resulting in the formation of mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative.
mannose inositol phosphoceramide biosynthetic process
mannose-inositol-P-ceramide (MIPC) biosynthetic process
mannosyl-inositol phosphorylceramide anabolism
mannosyl-inositol phosphorylceramide biosynthesis
mannosyl-inositol phosphorylceramide formation
mannosyl-inositol phosphorylceramide synthesis
MIPC biosynthetic process
Attachment of bacterial clusters to the surface of the host in a type IV pili dependent manner. The host is defined as the larger of the organisms involved in a symbiotic interaction.
type IV pili-dependent localized adherence to host
A process in which a symbiont inhibits or disrupts the normal execution of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
down regulation by symbiont of host ethylene-mediated defense response
down-regulation by symbiont of host ethylene-mediated defense response
downregulation by symbiont of host ethylene-mediated defense response
inhibition by symbiont of host ethylene-mediated defense response
negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction
negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction
negative regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway
negative regulation by symbiont of host ethylene-mediated defense response
suppression by organism of host ethylene-mediated defense response
suppression by symbiont of host ethylene-mediated defense response
The process in which an organism effects a change that impairs the structure or function of the host endomembrane system. The host is defined as the larger of the organisms involved in a symbiotic interaction.
disruption by symbiont of host cell membrane
modification by symbiont of host cell membrane
symbiont-mediated disruption of host cell membrane
symbiont-mediated perturbation of host cell membrane
A process in which a symbiont alters or subverts transcription in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
modulation by symbiont of host transcription