NothingMuch/GO-Terms huggingface dataset:
The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros.
pronephric tubule formation
pronephros tubule formation
The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior.
pronephric rectal diverticulum development
The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros.
cell proliferation involved in pronephric kidney development
Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ.
cell-cell signaling involved in pronephric kidney development
cell-cell signalling involved in pronephros development
Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
negative regulation by virus of host type I interferon production
suppression by virus of host interferon type I production
suppression by virus of host type I IFN production
A process in which a symbiont interferes with, inhibits or disrupts a type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
inhibition of host interferon signaling pathway by virus
negative regulation by virus of host type I interferon-mediated signaling pathway
suppression by virus of host type I IFN-mediated signaling pathway
suppression by virus of host type I interferon-mediated signaling pathway
suppression by virus of host type I interferon-mediated signalling pathway
A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC class II protein complex.
inhibition of host MHC class II molecule presentation by virus
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II
Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host.
activation of host autophagy by virus
autophagy of host cells involved in interaction with symbiont
positive regulation by virus of host autophagy
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host.
inhibition by virus of host autophagy
inhibition of host autophagy by virus
negative regulation by virus of host autophagy
A process in which a symbiont inhibits or disrupts the normal movement of mRNA from the nucleus to the cytoplasm of the host cell, leading to shutoff of host protein expression. The host is defined as the larger of the organisms involved in a symbiotic interaction.
inhibition by virus of host mRNA nuclear export
inhibition of host mRNA nuclear export by virus
negative regulation by virus of host mRNA nuclear export
suppression by virus of host mRNA export from nucleus
suppression of host mRNA nuclear export by virus
A process in which a symbiont inhibits or disrupts the transcription of genes into mRNA in its host by directly inhibiting host RNA polymerase II activity. The host is defined as the larger of the organisms involved in a symbiotic interaction.
inhibition of host RNA polymerase II activity by virus
inhibition of host RNA polymerase II by virus
negative regulation by virus of host RNA polymerase II activity
suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity
suppression by virus of host RNA polymerase II activity
A process in which a symbiont alters or subverts the organization of chromatin in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
modulation by virus of host chromatin organisation
modulation by virus of host chromatin organization
modulation of host chromatin by virus
modulation of host chromatin structure by virus
regulation by virus of host chromatin organization
A process in which a symbiont interferes with, inhibits or disrupts a TRAF-mediated signal transduction pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
disruption by virus of host TRAF-mediated signal transduction
inhibition of host TRAF-mediated signal transduction by virus
inhibition of host TRAFs by virus
negative regulation by virus of host TRAF-mediated signal transduction
suppression by virus of host TRAF activity
suppression by virus of host TRAF-mediated signal transduction
suppression by virus of host tumor necrosis factor receptor-associated factor signaling
Any process that stops, prevents, or reduces the frequency, rate or extent of the series of the MDA-5 signaling pathway.
negative regulation of IFIH1 signaling pathway
negative regulation of MDA-5 signalling pathway
negative regulation of MDA5 signaling pathway
negative regulation of melanoma differentiation-associated gene 5 signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of the RIG-I signaling pathway.
negative regulation of DDX58 signaling pathway
negative regulation of retinoic acid inducible gene I signaling pathway
negative regulation of RIG-I signalling pathway
A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
inhibition by virus of host DDX58 activity
inhibition by virus of host RIG-I
inhibition by virus of host RIG-I signaling
inhibition of host DDX58/RIG-I by virus
suppression by virus of host DDX58 signaling pathway
suppression by virus of host RIG-I activity
suppression by virus of host RIG-I signaling pathway
suppression by virus of host RIG-I signalling pathway
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity
symbiont-mediated suppression of host RIG-I signaling pathway
A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host MAVS (mitochondrial antiviral signaling protein). MAVS is a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses.
inhibition of host MAVS by virus
suppression by virus of host MAVS activity
suppression by virus of host mitochondrial antiviral-signaling protein
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.
inhibition of host IRF3 by virus
inhibition of IRF3-dependent antiviral response
suppression by virus of host interferon regulatory factor 3
suppression by virus of host IRF3 activity
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA.
DDX58 binding
DDX58/RIG-I binding
A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
inhibition by virus of host MDA-5 signaling
inhibition of host IFIH1/MDA5 by virus
Inhibition of host MDA5 by virus
suppression by virus of host IFIH1 signaling pathway
suppression by virus of host MDA-5 activity
suppression by virus of host MDA-5 signaling pathway
suppression by virus of host MDA-5 signalling pathway
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity
Binding to MDA-5, a cytoplasmic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA.
MDA5 binding
A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.
inhibition of host interferon regulatory factor-7 by virus
inhibition of host IRF7 by virus
suppression by virus of host interferon regulatory factor 7 activity
suppression by virus of host IRF7 activity
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. For example, viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes.
disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity
inhibition of host interferon regulatory factor-9 by virus
inhibition of host IRF9 by virus
suppression by virus of host interferon regulatory factor 9 activity
suppression by virus of host IRF9 activity
suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity
A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1).
disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity
inhibition by virus of host STAT1 activity
inhibition of host STAT1 by virus
suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity
suppression by virus of host STAT1 activity
A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2).
disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity
inhibition by virus of host STAT2 activity
inhibition of host STAT2 by virus
suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity
suppression by virus of host STAT2 activity
A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase involved in numerous cytokines and interferons signaling pathways and transmits the cytokine signal by phosphorylating receptor subunits.
disruption by virus of host JAK-STAT cascade via inhibition of host TYK2 activity
suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity
suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity
suppression by virus of host TYK2 activity
A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host JAK1 (Janus Kinase 1).
disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity
inhibition of host JAK activity by virus
negative regulation by virus of host JAK
negative regulation by virus of tyrosine phosphorylation of host STAT protein
suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity
suppression by virus of host JAK1 activity
suppression by virus of tyrosine phosphorylation of host STAT protein
viral inhibition of tyrosine phosphorylation of host STAT protein
Any process in which a symbiont inhibits or disrupts a host ubiquitin-like protein ISG15 conjugation to a substrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. For example, some viruses escape the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15, while the papain-like protease from the coronavirus cleaves ISG15 derivatives.
suppression by virus of host ISG15 activity
suppression by virus of host ISG15-protein conjugation
A process in which a symbiont inhibits or disrupts host PKR (Protein Kinase regulated by RNA) signaling. PKR phosphorylates host targets such as the translation initiation factor eIF2alpha that inhibits protein synthesis as an antimicrobial response. Inhibition of host PKR signaling maintains the host ability to translate mRNA. The host is defined as the larger of the organisms involved in a symbiotic interaction.
suppression by virus of host EIF2AK2 activity
suppression by virus of host PKR activity
suppression by virus of host PKR signaling
An intracellular signaling cassette that starts with activation and autophosphorylation of PKR (also known as EIF2AK2), which phosphorylates proteins including the translation initiation factor eIF2 to inhibit translation. PKR is activated by stress signals and during the antiviral response, activated by binding to viral double-stranded RNA (dsRNA) leading to inhibition of protein synthesis during viral infection.
EIF2AK2 signal transduction
EIF2AK2/PRK signaling
PKR signal transduction
PKR signaling pathway
signaling through PKR
Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects.
inhibition of host BST2/Tetherin by virus
A process in which a symbiont interferes with the progression of the host mitotic cell cycle from G2 phase to M phase, leading to arrest in G2 phase. The arrest in G2/M allows some viruses to replicate their genome before cells enter mitosis. Alternatively, it can inhibit the antiviral immune response by preventing the clonal expansion of infected lymphocytes.
host G2/M cell cycle arrest by virus
perturbation by virus of G2/M transition of host mitotic cell cycle
suppression by virus of G2/M transition of host mitotic cell cycle
A process in which a virus interferes with the host cell completing the M phase of the cell cycle.
inhibition of host mitotic exit by virus
perturbation by virus of host exit from mitosis
suppression by virus of host exit from mitosis
The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA).
induction by virus of catabolism of host mRNA
induction by virus of host mRNA catabolic process
induction of host mRNA decay
promotion of host mRNA degradation
viral induction of host mRNA decay
virus-mediated mRNA decay
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template. The host is defined as the larger of the organisms involved in a symbiotic interaction.
inhibition of host transcription initiation by virus
suppression by virus of host DNA-dependent transcription, initiation
suppression by virus of host transcription initiation from RNA polymerase II promoter
A process in which a symbiont inhibits or disrupts translation initiation in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
suppression by virus of host translation initiation
The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions.
outer capsid
The inner layer of a double or triple concentric icosahedral capsid. Inner capsids are part of reoviridae and cystoviridae virions.
inner capsid
The intermediate layer of a triple concentric icosahedral capsid. Intermediate capsids are part of reoviridae virions.
intermediate capsid
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins.
T=169 icosahedral capsid
The viral-killing of a host cell by a pre-existing virus in response to a subsequent infection of the host cell by second virus.
killing by virus of host cells during superinfection exclusion
killing by virus of host cells involved in superinfection exclusion
Rex exclusion
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls.
viral inhibition of host peptidoglycan biosynthesis
The process by which a virion attaches to a host cell by binding to a lipopolysaccharide (LPS) on the host cell surface.
lipopolysaccharide binding involved in viral attachment to host cell
LPS binding involved in viral attachment to host cell
virion attachment, binding to host lipopolysaccharide
The prevention or delay of host cell lysis by a pre-existing virus in response to a subsequent infection of the host cell by second virus.
lysis inhibition
suppression by virus of host cell lysis in response to superinfecting virus
The dissemination of mature viral particles from a host cell, caused by a virus stopping, preventing, or reducing peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls.
cytolysis by virus via suppression of host peptidoglycan biosynthetic process
viral exit by cytolysis via suppression of host peptidoglycan biosynthetic process
viral release by cytolysis via suppression of host peptidoglycan biosynthetic process
The lipid bilayer of a virion contained inside the protein capsid.
virion inner membrane
A process in which a symbiont interferes with the normal execution of the host cell G1/S transition checkpoint. The host is defined as the larger of the organisms involved in a symbiotic interaction.
G1/S host cell cycle checkpoint dysregulation by virus
modulation by virus of host G1/S transition checkpoint
perturbation by virus of host G1/S transition checkpoint
A process in which a symbiont interferes with the normal execution of the host cell G0/G1 transition checkpoint. The host is defined as the larger of the organisms involved in a symbiotic interaction. Some viruses benefit from keeping cells in resting state (G0), while others favor entry through G1 and subsequent cell division to replicate more efficiently.
G0/G1 host cell cycle checkpoint dysregulation by virus
modulation by virus of host G0/G1 transition checkpoint
perturbation by virus of host G0/G1 transition checkpoint
A process by which a symbiont alters ubiquitin-like protein modification of target proteins of either host or symbiont proteins. This includes ubiquitination, SUMOylation, NEDDylation, and ISG15ylation. The ubiquitination status of a protein  affects whether it is targeted to the proteasome for degradation. The host is defined as the larger of the organisms involved in a symbiotic interaction.
modulation by symbiont of host protein ubiquitination
modulation of host ubiquitin pathway by virus
symbiont-mediated perturbation of host protein SUMOlyation
symbiont-mediated perturbation of host protein ubiquitination
A protein complex containing TBK1 (TANK-binding kinase 1), IKBKE (I-Kappa-B kinase epsilon/IKKE/IKK-epsilon) and the DEAD box family RNA helicase DDX3.
TBK1-IKBKE-DDX3 complex
The action of a molecule that contributes to the structural integrity of a virion.
viral matrix protein
A lipid bilayer that forms the outermost layer of the cell envelope, occurring in a host cell.
host cell envelope outer membrane
outer membrane of host cell
The process by which a virion attaches to a host cell by binding to a pilus on the host cell surface. Pili are retractile filaments that protrude from gram-negative bacteria. Filamentous viruses can attach to the pilus tip, whereas icosahedral viruses can attach to the pilus side.
pilus-adsorption protein
pilus-mediated viral adsorption onto host cell
pilus-mediated viral attachment to host cell
viral attachment to host cell pilus
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation in the host.
suppression by virus of host NK-cell activation
Any process by which a virus avoids the effects mediated by the host organism's dendritic cells.
evasion by virus of host dendritic cell response
impairing dendritic cell function by virus
modulation of host dendritic cell activity by virus
The directed movement of the viral genome or a viral particle out of the host cell nucleus through the nuclear pore.
exit of virus from host cell nucleus through nuclear pore complex
nuclear pore exit of virus
viral enome export through nuclear pore
The directed movement of the viral genome or a viral particle out of the host cell nucleus that involves disruption of the nuclear membrane envelope by the virus.
exit of virus from host cell nucleus via nuclear envelope breakdown
The directed movement of a virus, or part of a virus, towards the host cell nucleus using actin filaments.
actin-dependent intracellular transport of viral material towards nucleus
actin-dependent inwards viral transport
A rolling circle viral DNA replication that begins with a double-stranded viral DNA genome.
dsDNA rolling circle replication
A rolling circle viral DNA replication that begins with a single-stranded viral DNA genome.
ssDNA rolling circle replication
A viral DNA replication process where a 3' hairpin structure in the viral single-stranded DNA (ssDNA) template serves as a primer for host enzymes to synthesize DNA.
ssDNA rolling hairpin viral DNA replication
A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions.
viral bidirectional dsDNA replication
A DNA replication process that uses viral RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands.
dsDNA replication via RNA intermediate
RNA-dependent viral DNA replication
viral RNA-dependent DNA replication
A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).
(-)ss viral RNA replication
A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA.
ss(+) viral RNA replication