NothingMuch/GO-Terms huggingface dataset:
The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.
megakaryocyte cell development
The process involved in the specification of identity of an eosinophil cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
eosinophil cell fate specification
The cell fate determination process in which a cell becomes capable of differentiating autonomously into an eosinophil cell regardless of its environment; upon determination, the cell fate cannot be reversed.
eosinophil cell fate determination
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
DNA damage foci
DNA damage focus
ionizing radiation-induced foci
IRIF
site of DSB
The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position.
2\'-Deoxyinosine 5\'-triphosphate catabolic process
2\'-Deoxyinosine-5\'-triphosphate catabolic process
deoxyinosine 5\'-triphosphate catabolic process
deoxyinosine triphosphate (2\'-deoxyinosine 5\'-triphosphate) catabolic process
dITP breakdown
dITP catabolism
dITP degradation
A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha.
alphav-beta3 integrin-PKCa complex
alphav-beta3 integrin-protein kinase C alpha complex
A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein.
alphav-beta3 integrin-high mobility group box 1 complex
Catalysis of the reaction: dITP + H2O = dIMP + H+ + diphosphate.
2\'-deoxyinosine-5\'-triphosphate pyrophosphohydrolase activity
deoxyinosine triphosphate pyrophosphatase activity
dITP pyrophosphatase activity
A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein.
protein K11-linked deubiquitinylation
protein K11-linked deubiquitylation
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of copper ions.
cellular response to copper starvation
Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).
DED binding
Catalysis of the reaction: H+ + H2O + isoguanine = NH4+ + xanthine.
2-hydroxyadenine deaminase activity
2-oxoadenine deaminase activity
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of platelet aggregation in a second organism.
disruption of platelet aggregation in other organism
down-regulation of platelet aggregation in other organism
downregulation of platelet aggregation in other organism
inhibition of platelet aggregation in other organism
negative regulation of platelet aggregation in another organism
negative regulation of platelet aggregation in other organism
Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism.
positive regulation of platelet aggregation in another organism
positive regulation of platelet aggregation in other organism
up-regulation of platelet aggregation in other organism
upregulation of platelet aggregation in other organism
Any process in which an organism increases the frequency, rate or extent of blood mast cell degranulation in another organism.
positive regulation of mast cell degranulation in other organism
up-regulation of mast cell degranulation in other organism
upregulation of mast cell degranulation in other organism
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species.
cellular response to social isolation
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.
cellular response to immobilisation stress
cellular response to restraint stress
The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism.
pore complex assembly in other organism
pore complex biogenesis in other organism
pore formation in membrane of other organism
pore formation in other organism
pore-forming toxin activity
Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a low voltage-gated calcium channel in another organism. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.
down-regulation of low voltage-gated calcium channel activity in other organism
downregulation of low voltage-gated calcium channel activity in other organism
inhibition of low voltage-gated calcium channel activity in other organism
negative regulation of low voltage gated calcium channel activity in other organism
negative regulation of low voltage-dependent calcium channel activity in other organism
negative regulation of low voltage-gated calcium channel activity in other organism
Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a high voltage-gated calcium channel in another organism. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.
down-regulation of high voltage-gated calcium channel activity in other organism
downregulation of high voltage-gated calcium channel activity in other organism
inhibition of high voltage-gated calcium channel activity in other organism
negative regulation of high voltage gated calcium channel activity in other organism
negative regulation of high voltage-dependent calcium channel activity in other organism
negative regulation of high voltage-gated calcium channel activity in other organism
The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
desmosome dissociation
The morphogenetic process in which the foramen ovale closes after birth, to prevent blood flow between the right and left atria. In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. Closure of the foramen ovale after birth stops this blood flow.
foramen ovale of heart closure
Binding to flurbiprofen.
2-(2-fluoro-)propanoic acid binding
Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
adenylate/uridylate-rich element binding
ARE binding
AU-rich element binding
mRNA 3\'-UTR adenylate/uridylate-rich element binding
The process in which a rRNA, ribosomal ribonucleic acid, transported from the cytosol into the mitochondrial matrix.
cytoplasmic rRNA import into mitochondrion
nuclear-encoded rRNA import into mitochondrion
Binding to a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem.
microsatellite DNA binding
variable number tandem repeat binding
VNTR binding
The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion.
mitochondrial aberrant ncRNA catabolic process
mitochondrial ncRNA quality control
mitochondrial non-coding RNA surveillance
The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion.
mitochondrial aberrant RNA catabolic process
mitochondrial messenger RNA surveillance
mitochondrial mRNA quality control
Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids.
cardiolipin acyl-chain remodelling
cardiolipin maturation
diphosphatidylglycerol remodeling
Catalysis of the reaction: histone H2AX-serine (position 139) + ATP = histone H2AX-phosphoserine (position 139) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 139 of histone variant H2AX.
histone H2AS139 kinase activity
histone kinase activity (H2A-S139 specific)
histone kinase activity (H2A.x-S139 specific)
A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes.
SAHF
senescence-associated heterochromatin foci
Binding to and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO).
NO sensor activity
The chemical reactions and pathways resulting in the formation of pyridoxal 5'-phosphate, the active form of vitamin B6, from simpler components.
\'de novo\' PLP biosynthesis
\'de novo\' pyridoxal 5\'-phosphate anabolism
\'de novo\' pyridoxal 5\'-phosphate biosynthesis
\'de novo\' pyridoxal 5\'-phosphate formation
\'de novo\' pyridoxal 5\'-phosphate synthesis
\'de novo\' pyridoxal phosphate biosynthetic process
The inner, i.e. lumen-facing, lipid bilayer of the cyanelle envelope; also faces the cyanelle stroma.
cyanelle inner envelope membrane
The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer.
cyanelle envelope lumen
cyanelle periplasm
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus.
cellular response to IL-3
The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.
endolysosomal membrane
The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.
endolysosomal lumen
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7.
PCI-TMPRSS7 complex
plasma serine protease inhibitor-TMPRSS7 complex
protein C inhibitor-matriptase-3 complex
protein C inhibitor-transmembrane protease serine 7 complex
serpin A5-TMPRSS7 complex
SERPINA5-TMPRSS7 complex
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E.
PCI-TMPRSS11E complex
plasma serine protease inhibitor-TMPRSS11E complex
protein C inhibitor-transmembrane protease serine 11E complex
serpin A5-TMPRSS11E complex
SERPINA5-TMPRSS11E complex
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator.
PCI-PLAT complex
plasma serine protease inhibitor-PLAT complex
protein C inhibitor-tissue-type plasminogen activator complex
protein C inhibitor-tPA complex
serpin A5-PLAT complex
SERPINA5-PLAT complex
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator.
PCI-PLAU complex
plasma serine protease inhibitor-PLAU complex
protein C inhibitor-U-plasminogen activator complex
protein C inhibitor-uPA complex
protein C inhibitor-urokinase-type plasminogen activator complex
serpin A5-PLAU complex
SERPINA5-PLAU complex
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin.
PCI-thrombin complex
plasma serine protease inhibitor-thrombin complex
protein C inhibitor-coagulation factor II complex
protein C inhibitor-F2 complex
serpin A5-thrombin complex
SERPINA5-thrombin complex
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen.
PCI-KLK3 complex
plasma serine protease inhibitor-KLK3 complex
protein C inhibitor-kallikrein-3 complex
protein C inhibitor-prostate-specific antigen complex
serpin A5-KLK3 complex
SERPINA5-KLK3 complex
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein.
PCI-plasma kallikrein complex
plasma serine protease inhibitor-plasma kallikrein complex
protein C inhibitor-KLKB1 complex
serpin A5-plasma kallikrein complex
SERPINA5-plasma kallikrein complex
A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.
B9 complex
MKS module
TCTN-B9D complex
tectonic complex
tectonic-like complex
The chemical reactions and pathways resulting in the breakdown of the polyphenol, curcumin.
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione breakdown
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolic process
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolism
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione degradation
curcumin breakdown
curcumin catabolism
curcumin degradation
diferuloylmethane breakdown
diferuloylmethane catabolic process
diferuloylmethane catabolism
diferuloylmethane degradation
turmeric yellow breakdown
turmeric yellow catabolic process
turmeric yellow catabolism
turmeric yellow degradation
Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
long-chain fatty acyl-coenyme A binding
A process in which a protein is transported to, or maintained in, a uropod. A uropod is a membrane projection with related cytoskeletal components at the trailing edge of a migrating cell.
protein localisation to uropod
A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes.
GEnC fenestration
glomerular endothelial cell fenestration
Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide.
peptidyl-malonyllysine demalonylase activity
protein lysine demalonylation activity
protein malonyl lysine demalonylation activity
Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl- + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl- + nicotinamide.
peptidyl-succinyllysine desuccinylase activity
succinyl lysine desuccinylase activity
succinyllysine desuccinylase activity
A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development.
periactive zone
pre-synaptic periactive zone
A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle.
spermatid acroblast
The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the presence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants.
light dependent bacteriochlorophyll biosynthetic process
light-dependent bacteriochlorophyll anabolism
light-dependent bacteriochlorophyll biosynthesis
light-dependent bacteriochlorophyll formation
light-dependent bacteriochlorophyll synthesis
The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the absence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants.
light independent bacteriochlorophyll biosynthetic process
light-independent bacteriochlorophyll anabolism
light-independent bacteriochlorophyll biosynthesis
light-independent bacteriochlorophyll formation
light-independent bacteriochlorophyll synthesis
The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains.
glycoprotein fucosylation
Direct ossification in which bone formation occurs as result of the direct transformation of non-bone cells into bone cells without cell division.
metaplasia
Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts.
extracellular ammonia-gated ion channel activity
ionotropic ammonia receptor activity
Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts.
extracellular phenylacetaldehyde-gated ion channel activity
ionotropic phenylacetaldehyde receptor activity
The directed movement of GDP-fucose into the endoplasmic reticulum lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate.
GDP-fucose import into endoplasmic reticulum
GDP-fucose transport across endoplasmic reticulum membrane
GDP-fucose transport into endoplasmic reticulum lumen
The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate.
GDP-fucose import into Golgi
GDP-fucose transport across Golgi membrane
GDP-fucose transport into Golgi lumen
A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer.
glutathione synthetase complex
The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
D-serine breakdown
D-serine catabolism
D-serine degradation
The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.
phosphatidylinositol-3-phosphate anabolism
phosphatidylinositol-3-phosphate biosynthesis
phosphatidylinositol-3-phosphate formation
phosphatidylinositol-3-phosphate synthesis
PI(3)P biosynthesis
PtdIns3P biosynthesis
The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.
leukotriene B4 breakdown
leukotriene B4 catabolism
leukotriene B4 degradation
LTB4 catabolism
The chemical reactions and pathways resulting in the formation of Kdo2-lipid A, a lipopolysaccharide (LPS) component.
3-deoxy-d-manno-octulosonic acid-lipid A biosynthesis
Kdo2-lipid A anabolism
Kdo2-lipid A biosynthesis
Kdo2-lipid A formation
Kdo2-lipid A synthesis
Binding to a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner.
class 1 mPTS binding
PEX19-dependent mPTS binding
Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner.
class 2 mPTS binding
PEX19-independent mPTS binding
The chemical reactions and pathways resulting in the formation of 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N).
4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate anabolism
4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthesis
4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate formation
4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate synthesis
undecaprenyl phosphate alpha-L-Ara4N biosynthesis
The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
ALA metabolism
alpha-linolenic acid metabolism
The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a very long-chain fatty-acyl group. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.
very long-chain fatty-acyl-CoA breakdown
very long-chain fatty-acyl-CoA catabolism
very long-chain fatty-acyl-CoA degradation
The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
medium-chain fatty-acyl-CoA breakdown
medium-chain fatty-acyl-CoA catabolism
medium-chain fatty-acyl-CoA degradation
The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
long-chain fatty-acyl-CoA breakdown
long-chain fatty-acyl-CoA catabolism
long-chain fatty-acyl-CoA degradation
A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan.
HA cable
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
cellular response to PDGF stimulus