NothingMuch/GO-Terms huggingface dataset:
Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid.
cytochrome P450 CYP261
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
gonadogenesis
The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.
bristle morphogenesis
Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
3\'-5\'-exonuclease activity
Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate.
CTD phosphatase activity
RNA polymerase II carboxy-terminal domain phosphatase activity
Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.
amygdalase activity
amygdalinase
arbutinase activity
aryl-beta-glucosidase activity
beta-1,6-glucosidase activity
beta-D-glucosidase activity
beta-D-glucoside glucohydrolase activity
beta-glucoside glucohydrolase activity
cellobiase activity
cytokine beta-glucosidase activity
elaterase activity
emulsin
gentiobiase activity
gentobiase activity
limarase activity
p-nitrophenyl beta-glucosidase activity
primeverosidase activity
quercetin 3\'-O-beta-D-glucopyranoside hydrolase activity
quercetin 4\'-O-beta-D-glucopyranoside hydrolase activity
salicilinase activity
Binds to and stops, prevents or reduces the activity of ribonuclease.
RNA nuclease inhibitor activity
Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose.
IAG-NH activity
IAG-nucleoside hydrolase activity
inosine-adenosine-guanosine preferring nucleoside hydrolase activity
N-D-ribosylpurine ribohydrolase activity
N-ribosyl purine ribohydrolase activity
nucleosidase activity
nucleosidase g activity
nucleoside hydrolase activity
purine beta-ribosidase activity
purine nucleosidase reaction
purine nucleoside hydrolase activity
purine ribonucleosidase activity
purine-nucleoside ribohydrolase activity
purine-specific nucleoside N-ribohydrolase activity
ribonucleoside hydrolase activity
Catalysis of the reaction: a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H+.
ATP:sphinganine 1-phosphotransferase activity
dihydrosphingosine kinase (phosphorylating)
dihydrosphingosine kinase activity
sphinganine kinase activity
sphingosine kinase (phosphorylating)
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
aminotransferase activity
Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.
sulfatase activity
sulphuric ester hydrolase activity
Catalysis of the reaction: diphospho-1D-myo-inositol polyphosphate + H2O = 1D-myo-inositol polyphosphate + phosphate.
diphospho-myo-inositol-polyphosphate diphosphohydrolase activity
diphosphoinositol polyphosphate phosphohydrolase activity
diphosphoinositol-polyphosphate phosphohydrolase activity
DIPP activity
Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).
tetracyclin transporter activity
tetracycline transporter activity
Enables the transfer of a negatively charged ion from one side of a membrane to the other.
anion transmembrane transporter activity
anion transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in).
sulfate/hydrogen symporter activity
sulfate:hydrogen symporter activity
sulphate:hydrogen symporter activity
Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane.
sucrose permease (PTS) activity
sucrose permease activity
Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
folate transmembrane transporter activity
folate transporter activity
folic acid transporter activity
vitamin B9 transporter activity
vitamin M transporter activity
Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
acetyl-CoA transporter activity
Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
phosphatidylcholine transmembrane transporter activity
Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.
gustatory receptor
Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
G protein coupled peptide receptor activity
G-protein coupled peptide receptor activity
peptide receptor activity, G protein coupled
peptide receptor activity, G-protein coupled
Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.
2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity
2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity
8-oxoguanine DNA glycosylase activity
bifunctional DNA glycosylase activity
deoxyribonucleate glycosidase activity
DNA glycohydrolase
DNA glycosylase/AP-lyase activity
DNA glycosylase/beta-lyase activity
DNA-formamidopyrimidine glycosylase activity
Fapy-DNA glycosylase activity
formamidopyrimidine-DNA glycosylase activity
Fpg protein
oxidized purine base lesion DNA N-glycosylase activity
purine-specific oxidized base lesion DNA N-glycosylase activity
The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms.
cytochrome c oxidase biogenesis
cytochrome c oxidase complex assembly
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
FGF receptor signaling pathway
FGF receptor signalling pathway
FGFR signaling pathway
fibroblast growth factor receptor signalling pathway
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
hypodermis development
Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.
H+-exporting ATPase activity
H+-transporting ATPase
H+-transporting ATPase activity
hydrogen exporting ATPase activity, phosphorylative mechanism
hydrogen-/sodium-translocating ATPase activity
hydrogen-exporting ATPase activity
hydrogen-exporting ATPase activity, phosphorylative mechanism
P-type H+-exporting ATPase activity
proton transport ATPase activity
proton-exporting ATPase activity
proton-exporting ATPase activity, phosphorylative mechanism
proton-translocating ATPase activity
proton-transporting ATPase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism.
Na(+)-exporting ATPase activity
Na(+)-transporting ATPase activity
Na+-exporting ATPase activity
Na+-transporting ATPase activity
sodium exporting ATPase activity, phosphorylative mechanism
sodium transmembrane transporter activity, phosphorylative mechanism
sodium transport ATPase activity
sodium-exporting ATPase activity
sodium-exporting ATPase activity, phosphorylative mechanism
sodium-translocating P-type ATPase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in).
ATP phosphohydrolase (K+-importing)
ATP-dependent potassium transmembrane transporter activity
ATPase-coupled potassium transmembrane transporter activity
K(+)-importing ATPase activity
K(+)-transporting ATPase activity
K+-importing ATPase activity
K+-transporting ATPase activity
potassium ABC transporter
potassium transmembrane transporter activity, phosphorylative mechanism
potassium transporting ATPase activity
potassium-importing ATPase activity
potassium-transporting ATPase activity
potassium-uptake-ATPase activity
Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP phosphohydrolase (xenobiotic-exporting)
ATP-dependent xenobiotic transmembrane transporter activity
ATPase-coupled xenobiotic transmembrane transporter activity
MDR protein
multidrug resistance exporter
multidrug-resistance protein
P-glycoprotein
PDR protein
pleiotropic-drug-resistance protein
xenobiotic ABC transporter
xenobiotic transmembrane transporting ATPase activity
Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions.
regulation of synaptic growth at neuromuscular junction
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
testicular development
testis development
The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
ovarian development
ovary development
The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade.
wing margin morphogenesis
Any process that modulates the frequency, rate or extent of smoothened signaling.
regulation of hedgehog signaling pathway
regulation of hh signaling pathway
regulation of smoothened activity
regulation of smoothened by patched
regulation of smoothened receptor activity by patched
regulation of smoothened signalling pathway
Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
regulation of frizzled-2 signaling pathway
regulation of frizzled-2 signalling pathway
regulation of Wnt receptor signaling pathway, calcium modulating pathway
regulation of Wnt-activated signaling pathway, calcium modulating pathway
Any process that modulates the frequency, rate or extent of the Tl signaling pathway.
regulation of Tl signaling pathway
regulation of Tl signalling pathway
regulation of Toll signalling pathway
Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
regulation of N signaling pathway
regulation of N signalling pathway
regulation of Notch signalling pathway
The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.
photoreceptor development
The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.
anterior/posterior axis determination, embryo
Modulation of the activity of the enzyme cAMP-dependent protein kinase.
3\',5\' cAMP-dependent protein kinase regulator activity
3\',5\'-cAMP-dependent protein kinase regulator activity
adenosine 3\',5\'-cyclophosphate-dependent protein kinase regulator activity
cAMP-dependent protein kinase, intrinsic regulator activity
cyclic AMP-dependent protein kinase regulator activity
The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.
amphotelic attachment
attachment of spindle microtubules to chromosome
bipolar attachment
kinetochore microtubule interaction
kinetochore-microtubule attachment
kinetochore-microtubule interaction
microtubule anchoring at kinetochore
microtubule and chromosome interaction
microtubule and kinetochore interaction
microtubule capture
spindle chromosome attachment
spindle kinetochore attachment
spindle-chromosome interaction
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
lipid anabolism
lipid biosynthesis
lipid formation
lipid synthesis
lipogenesis
The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
ether lipid anabolism
ether lipid biosynthesis
ether lipid formation
ether lipid synthesis
plasmalogen biosynthetic process
The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.
pyridoxine metabolism
The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents.
queuosine anabolism
queuosine biosynthesis
queuosine formation
queuosine synthesis
The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution.
guanosine metabolism
The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA.
7-methylguanosine metabolism
The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
death receptor-mediated apoptosis
induction of apoptosis via death domain receptors
induction of apoptosis via death receptors
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered.
induction of apoptosis by ionic changes
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
DNA damage response, signal transduction resulting in induction of apoptosis
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
induction of apoptosis by oxidative stress
oxidative stress-induced intrinsic apoptotic signaling pathway
Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.
small protein activating enzyme activity
The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
sugar transport
The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule.
hexose membrane transport
hexose transport
high-affinity hexose transport
low-affinity hexose transport
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
amino acid anabolism
amino acid biosynthesis
amino acid formation
amino acid synthesis
cellular amino acid biosynthetic process
The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.
lipopolysaccharide metabolism
LPS metabolic process
The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.
phospholipid anabolism
phospholipid biosynthesis
phospholipid formation
phospholipid synthesis
Any process that generates a pyrimidine-containing compound, a nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis.
pyrimidine salvage
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
S-adenosyl methionine-dependent methyltransferase activity
SAM-dependent methyltransferase activity
Catalysis of the reaction: an L-alpha aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
ArAT
aromatic amino acid aminotransferase activity
aromatic amino acid transferase activity
aromatic aminotransferase activity
aromatic-amino-acid:2-oxoglutarate aminotransferase activity
Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde.
choline oxidase activity
choline-cytochrome c reductase activity
choline:(acceptor) 1-oxidoreductase activity
choline:(acceptor) oxidoreductase activity
choline:acceptor 1-oxidoreductase activity
Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+.
(R)- or (S)-propane-1,2-diol:NAD+ oxidoreductase activity
lactaldehyde:propanediol oxidoreductase activity
propanediol oxidoreductase activity
propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity
Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+.
LPS heptosyltransferase activity
Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues.
murein transglycosylase B activity
peptidoglycan lytic transglycosylase activity
Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+.
ferredoxin reductase activity
Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor.
nitrate reductase (acceptor)
nitrite:(acceptor) oxidoreductase
nitrite:acceptor oxidoreductase
respiratory nitrate reductase activity
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
enzyme II of the phosphotransferase system
PEP--sugar phosphotransferase enzyme II activity
PEP-dependent phosphotransferase enzyme II
phosphoenolpyruvate-sugar phosphotransferase enzyme II
phosphohistidinoprotein-hexose phosphotransferase activity
phosphoprotein factor-hexose phosophotransferase activity
phosphotransfer-driven group translocator
protein-Np-phosphohistidine-sugar phosphotransferase activity
PTS permease activity
PTS transporter
Catalysis of the reaction: adenosine in rRNA + S-adenosyl-L-methionine = H+ + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine.
ErmC 23S rRNA methyltransferase
gene ksgA methyltransferase
ribonucleic acid-adenine (N(6)) methylase activity
ribonucleic acid-adenine (N6) methylase activity
ribosomal ribonucleate adenine 6-methyltransferase activity
S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity
S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity
Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine.
ribosomal ribonucleate guanine 1-methyltransferase activity
S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity
S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity
Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine.
ribosomal ribonucleate guanine-2-methyltransferase activity
S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity
S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity
Catalysis of the transfer of a methyl group to a DNA molecule.
deoxyribonucleate methylase activity
deoxyribonucleate methyltransferase activity
deoxyribonucleic acid methylase activity
deoxyribonucleic acid methyltransferase activity
deoxyribonucleic acid modification methylase activity
DNA methylase
DNA methyltransferase activity
DNA transmethylase activity
Type II DNA methylase
Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences.
RecA-family recombinase activity
Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+.
succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))
succinate-semialdehyde:NAD(P)+ oxidoreductase activity
Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate.
ATP:undecaprenol phosphotransferase activity
C55-isoprenoid alcohol kinase activity
C55-isoprenoid alcohol phosphokinase activity
C55-isoprenyl alcohol phosphokinase activity
isoprenoid alcohol kinase (phosphorylating)
isoprenoid alcohol kinase activity
isoprenoid alcohol phosphokinase activity
isoprenoid-alcohol kinase activity
polyisoprenol kinase activity
Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by heterochromatin formation leading to a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex.
Barr body formation
chromosome inactivation
X chromosome inactivation