NothingMuch/GO-Terms huggingface dataset:
Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.
receptor signalling protein tyrosine kinase inhibitor activity
Binds to and increases the activity of a receptor signaling protein tyrosine kinase.
receptor signalling protein tyrosine kinase activator activity
Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains.
heparinase activity
The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.
poly-N-acetyllactosamine breakdown
poly-N-acetyllactosamine catabolism
poly-N-acetyllactosamine degradation
The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.
poly-N-acetyllactosamine anabolism
poly-N-acetyllactosamine biosynthesis
poly-N-acetyllactosamine formation
poly-N-acetyllactosamine synthesis
Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules).
triad junction
The chemical reactions and pathways resulting in the breakdown of prenylated proteins.
prenylated protein breakdown
prenylated protein catabolism
prenylated protein degradation
The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.
prenylcysteine breakdown
prenylcysteine catabolism
prenylcysteine degradation
Binding to a nuclear estrogen receptor.
estrogen receptor binding
An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.
processivity clamp
sliding clamp
Catalysis of the reaction: CMP-N-acetyl-beta-neuraminate + 2 Fe(II)- + 2 H+ + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)- + H2O.
CMP-N-acetylneuraminate hydroxylase activity
CMP-N-acetylneuraminic acid hydroxylase activity
CMP-Neu5Ac hydroxylase activity
cytidine monophosphoacetylneuraminate monooxygenase activity
Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol.
FAEE synthase activity
FAEES activity
fatty-acyl ethyl ester synthase
long-chain-fatty-acyl-ethyl-ester acylhydrolase activity
Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.
glucuronoglycosaminoglycan lyase activity
hyaluronidase
hyaluronidase activity
mucinase activity
spreading factor activity
Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups.
ChnAC
chondroitin AC eliminase activity
chondroitin lyase activity
chondroitin sulfate lyase activity
chondroitinase AC
chondroitinase activity
Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol).
1,25-(OH)2D3 24-hydroxylase activity
calcitriol 24-hydroxylase activity
Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O.
cholecalciferol 25-hydroxylase activity
Binding to a protein phosphatase 2B.
calcineurin binding
protein phosphatase 3 binding
Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins.
IRE binding
Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist.
FGF receptor antagonist activity
FGFR antagonist activity
Binding to an interleukin-17 receptor.
IL-17
interleukin-17 receptor ligand
Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1.
ICAM-3 receptor binding
ICAM-3 receptor ligand
intercellular adhesion molecule-3 receptor ligand
Binding to a high molecular weight B cell growth factor receptor.
high molecular weight B cell growth factor receptor ligand
high molecular weight B lymphocyte growth factor receptor binding
high molecular weight B-cell growth factor receptor binding
high molecular weight B-lymphocyte growth factor receptor binding
Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity.
high molecular weight B lymphocyte growth factor receptor activity
high molecular weight B-cell growth factor receptor activity
high molecular weight B-lymphocyte growth factor receptor activity
HMW-BCGF receptor
A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
ligand-activated RNA polymerase II transcription factor binding transcription factor activity
ligand-dependent nuclear receptor transcription co-activator activity
ligand-dependent nuclear receptor transcription coactivator activity
nuclear receptor transcription coactivator activity
transcription factor activity, ligand-activated RNA polymerase II transcription factor binding
Combining with the urokinase plasminogen activator to initiate a change in cell activity.
U-plasminogen activator receptor activity
uPAR
urokinase plasminogen activator receptor
Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins.
neurotensin receptor activity, non G protein coupled
neurotensin receptor activity, non-G-protein coupled
non G protein coupled neurotensin receptor activity
non-G-protein coupled neurotensin receptor activity
non-G-protein-coupled neurotensin receptor activity
Binding to an interleukin-17E receptor.
IL-17E
interleukin-17E receptor ligand
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm.
sperm mitochondria organisation
sperm mitochondria organization and biogenesis
sperm mitochondrion organization and biogenesis
A protein complex that possesses ferredoxin-thioredoxin reductase activity.
ferredoxin:thioredoxin reductase complex
The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group.
fructoseglycine metabolism
The controlled breakdown of the membranes of autophagosomes.
autophagic membrane breakdown
autophagic membrane catabolism
autophagic membrane degradation
autophagic vacuole membrane disassembly
Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine.
5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity
FIG formiminotransferase activity
formimidoyltransferase activity
formiminoglycine formiminotransferase activity
formiminotransferase activity
glycine formiminotransferase activity
Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.
5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity
formimidoyltransferase activity
formiminoglutamic acid transferase activity
formiminoglutamic formiminotransferase activity
formiminotransferase activity
glutamate formiminotransferase activity
glutamate formyltransferase activity
Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H+ + nicotianamine.
S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity
Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O.
scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)
scytalone 7,8-hydro-lyase activity
Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H+ = 5,10-methenyltetrahydrofolate + NH4.
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)
formiminotetrahydrofolate cyclodeaminase activity
The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid.
nicotianamine anabolism
nicotianamine biosynthesis
nicotianamine formation
nicotianamine synthesis
The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid.
nicotianamine breakdown
nicotianamine catabolism
nicotianamine degradation
Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine + H+. Also acts on 3'-hydroxykynurenine and some other (3-arylcarbonyl)- alanines.
kynurenine hydrolase activity
L-kynurenine hydrolase activity
Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.
formation of symbiont invasive hypha in host
formation of symbiont invasive hypha within host
formation of symbiont invasive hypha within host during symbiotic interaction
invasive hyphal growth
symbiont invasive hypha formation within host
The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae.
spore wall assembly
The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants.
bacteriochlorophyll breakdown
bacteriochlorophyll catabolism
bacteriochlorophyll degradation
Enables the transfer of inorganic diphosphate across a membrane.
inorganic pyrophosphate transporter activity
The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
inorganic pyrophosphate transport
Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.
activation of transforming growth factor beta receptor signaling pathway
positive regulation of TGF-beta receptor signaling pathway
positive regulation of TGFbeta receptor signaling pathway
positive regulation of transforming growth factor beta receptor signalling pathway
stimulation of transforming growth factor beta receptor signaling pathway
up regulation of transforming growth factor beta receptor signaling pathway
up-regulation of transforming growth factor beta receptor signaling pathway
upregulation of transforming growth factor beta receptor signaling pathway
Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
activation of BMP signaling pathway
positive regulation of BMP receptor signaling pathway
positive regulation of BMP signalling pathway
positive regulation of bone morphogenetic protein signaling pathway
positive regulation of bone morphogenetic protein signalling pathway
positive regulation of decapentaplegic receptor signaling pathway
positive regulation of decapentaplegic receptor signalling pathway
positive regulation of decapentaplegic signaling pathway
stimulation of BMP signaling pathway
up regulation of BMP signaling pathway
up-regulation of BMP signaling pathway
upregulation of BMP signaling pathway
The heterodimeric receptor for granulocyte macrophage colony-stimulating factor.
GM-CSF receptor complex
granulocyte macrophage colony stimulating factor receptor complex
Feeding behavior in a larval (immature) organism.
larval feeding behaviour
The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized.
embryonic genital morphogenesis
Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
3\',5\' cAMP binding
3\',5\'-cAMP binding
adenosine 3\',5\'-cyclophosphate binding
cyclic AMP binding
Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
3\',5\' cGMP binding
3\',5\'-cGMP binding
cyclic GMP binding
Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends.
(1->4)-alpha-D-galacturonan lyase activity
alpha-1,4-D-endopolygalacturonic acid lyase activity
endo-alpha-1,4-polygalacturonic acid lyase activity
endogalacturonate transeliminase activity
endopectin methyltranseliminase activity
pectate transeliminase activity
pectic acid lyase activity
pectic acid transeliminase activity
pectic lyase activity
pectin trans-eliminase activity
PGA lyase activity
polygalacturonate lyase activity
polygalacturonic acid lyase activity
polygalacturonic acid trans-eliminase activity
polygalacturonic transeliminase activity
PPase-N activity
The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.
bile acid 7alpha-dehydroxylation pathway
bile acid breakdown
bile acid catabolism
bile acid degradation
cholate catabolic process
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors.
Cajal body organisation
Cajal body organization and biogenesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies.
Lands organisation
Lands organization and biogenesis
LYSP100-associated nuclear domain organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).
PML body organisation
PML body organization and biogenesis
The process whose specific outcome is the progression of the myxococcal fruiting body over time, from its formation to the mature structure. The process begins when myxococci respond to a lack of nutrients in the environment and ends when the myxococcal fruiting body is a mature structure.
fruiting body development in cellular response to starvation
fruiting body development in response to starvation
Catalysis of the reaction: diphosphate + oxaloacetate = CO2 + phosphate + phosphoenolpyruvate.
diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)
diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)
PEP carboxyphosphotransferase activity
PEPCTrP
phosphoenolpyruvate carboxykinase (pyrophosphate) activity
phosphoenolpyruvate carboxylase (pyrophosphate)
phosphoenolpyruvate carboxyphosphotransferase activity
phosphoenolpyruvate carboxytransphosphorylase activity
phosphoenolpyruvic carboxykinase
phosphoenolpyruvic carboxykinase (pyrophosphate)
phosphoenolpyruvic carboxylase (pyrophosphate)
phosphoenolpyruvic carboxytransphosphorylase activity
phosphopyruvate carboxykinase
phosphopyruvate carboxykinase (pyrophosphate)
phosphopyruvate carboxylase (pyrophosphate)
Catalysis of the reaction: -cob(II)alamin + NADPH + H+ + S-adenosyl methionine = -methylcob(I)alamin + S-adenosylhomocysteine + NADP+.
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
-cobalamin methyltransferase (cob(II)alamin reducing) activity
methionine synthase cob(II)alamin reductase (methylating) activity
methionine synthase reductase activity
methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)
methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity
Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster.
pseudocleavage during syncytial blastoderm formation
Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form.
NAD DNA ADP-ribosyltransferase activity
Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.
alpha-L-rhamnosidase N
alpha-L-rhamnosidase T
alpha-L-rhamnoside rhamnohydrolase activity
Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species.
gelonin
mirabilis antiviral protein
momorcochin-S
nigrin b
ribosomal ribonucleate N-glycosidase activity
ricin
RNA N-glycosidase activity
rRNA N-glycohydrolase activity
rRNA N-glycosidase activity
saporins
Catalysis of the reaction: pectin + n H2O = n methanol + pectate.
pectase activity
pectin demethoxylase activity
pectin methoxylase activity
pectin methyl esterase activity
pectin methylesterase activity
pectin pectylhydrolase activity
pectinoesterase activity
Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide.
4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity
cinnAE
cinnamoyl ester hydrolase activity
FAE-I
FAE-II
FAE-III
FAEA
ferulic acid esterase activity
hemicellulase accessory
hydroxycinnamoyl esterase activity
Catalysis of the reaction: H2O + oxaloacetate = acetate + H+ + oxalate.
oxalacetic hydrolase activity
oxaloacetate acetylhydrolase activity
Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + H+ + NADPH.
1-deoxy-D-xylulose-5-phosphate isomeroreductase activity
1-deoxyxylulose-5-phosphate reductoisomerase activity
2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)
2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity
DOXP reductoisomerase activity
DXP-reductoisomerase activity
Binding to a pre-mRNA 5' splice site sequence.
pre-mRNA 5\' splice site binding
Binding to a pre-mRNA 3' splice site sequence.
pre-mRNA 3\' splice site binding
Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end.
U6 snRNA 3\' end binding
The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases.
lysine methylamine methyltransferase cofactor adduct incorporation
monomethylamine methyltransferase cofactor lysine adduct incorporation
The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid.
D-alanine anabolism
D-alanine biosynthesis
D-alanine formation
D-alanine synthesis
A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2).
acetyl CoA pathway
Ljungdahl-Wood pathway
reductive acetyl CoA pathway
A homeostatic process involved in the maintenance of a steady state level of sulfate ions within a cell.
cellular sulfate ion homeostasis
sulphate ion homeostasis
A homeostatic process involved in the maintenance of a steady state level of phosphate ions within a cell.
cellular phosphate ion homeostasis
intracellular phosphate homeostasis
intracellular Pi homeostasis
A homeostatic process involved in the maintenance of a steady state level of chloride ions within a cell.
cellular chloride ion homeostasis
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum.
butyrate fermentation
glucose fermentation to butyrate
The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.
axonal membrane
A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species. The complex contains a single RNA molecule and a single protein molecule in yeast (PMID:12045094), but comprises three proteins and lacks an RNA component in humans.
mitochondrial RNase P complex
A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.
cyanelle RNase P complex
A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species.
dimeric RNase P complex
A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis.
Nop7 complex
Nop7 subcomplex
Catalysis of the reaction: S-adenosyl-L-methionine + uridine54 in tRNA = 5-methyluridine54 in tRNA + H+ + S-adenosyl-L-homocysteine.
M5U-methyltransferase activity
ribothymidyl synthase activity
RUMT
RUMT activity
S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity
S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity
S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity
transfer RNA uracil 5-methyltransferase activity
transfer RNA uracil methylase activity
tRNA (uracil(54)-C(5))-methyltransferase activity, S-adenosyl methionine-dependent
tRNA (uracil-5-)-methyltransferase activity
tRNA uracil 5-methyltransferase activity
tRNA:m(5)U54-methyltransferase activity
tRNA:m5U54-methyltransferase activity
Catalysis of the reaction: acetyl phosphate + H2O + NH4 + thioredoxin disulfide = glycine + H+ + phosphate + thioredoxin.
acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)
Catalysis of the reaction: NAD+ +  = nicotinamide + ADP-D-ribosyl-.
ADP-ribosyltransferase activity
NAD+: (ADP-D-ribosyl)transferase activity
NAD--azoferredoxin (ADP-ribose)transferase activity
NAD-azoferredoxin (ADPribose)transferase activity
NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity