NothingMuch/GO-Terms huggingface dataset:
The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex.
mitochondrial respiratory chain supercomplex assembly
mitochondrial respiratory supercomplex assembly
Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons.
oligodendrocyte apoptosis
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.
autolysis
self-proteolysis
Any biological process involved in the maintenance of an internal steady state of ammonium.
ammonia homeostasis
Any apoptotic process in a keratinocyte. A keratinocyte is an epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.
keratinocyte apoptosis
Any apoptotic process in a hepatocyte, the main structural component of the liver.
hepatocyte apoptosis
The chemical reactions and pathways involving the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolopyrimidine-5-carbonitrile or preQo.
7-cyano-7-deazaguanine metabolism
The chemical reactions and pathways involving XMP, xanthosine monophosphate.
XMP metabolism
The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate.
XMP anabolism
XMP biosynthesis
XMP formation
XMP synthesis
A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
programmed cell death by necrosis
regulated necrosis
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus.
process resulting in tolerance to alcohol
The aggregation, arrangement and bonding together of the apoptosome, a multisubunit protein complex involved in the signaling phase of the apoptotic process.
apoptosome formation
A membrane tubulation process occurring in a plasma membrane.
membrane tubulation
vesicle scission
Any process that prevents the proteolytic processing of an inactive enzyme to an active form.
prevention of zymogen activation
The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
mitochondrial outer membrane permeabilization during apoptotic cell death
mitochondrion outer membrane permeabilization
MOMP
Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
autophagic vacuole fusion
autophagic vacuole maturation
autophagosome fusion
The regionalization process in which the areas along the centrolateral axis are established that will lead to differences in cell differentiation, or in which cells interpret a specific environment.
mediolateral pattern formation
Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin.
protein localisation to heterochromatin
Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + -L-serine = UDP + -3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + -L-threonine = UDP + -3-O-(N-acetyl-D-glucosaminyl)-L-threonine.
O-GlcNAc transferase
O-linked N-acetylglucosaminyltransferase
OGTase
protein O-GlcNAc transferase activity
UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase
Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential.
stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential
Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions.
establishment of blood-testis barrier
establishment of BTB
establishment of SCB
The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A dorsal spinal cord interneuron is an interneuron located in the dorsal part of the spinal cord.
dorsal interneuron axon guidance
A prolongation or process extending from a glial cell.
glial process
glial projection
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus.
response to IL-32
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus.
response to IL-17
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus.
cellular response to IL-32
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus.
cellular response to IL-17
The series of molecular signals initiated by interleukin-17 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-17-mediated signaling pathway
IL-17-mediated signalling pathway
interleukin-17-mediated signalling pathway
The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.
synaptic vesicle lumen pH reduction
synaptic vesicle proton loading  syngo_official_label
The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.
HIF1alpha pathway
hypoxia-inducible factor signaling
hypoxia-inducible factor-1alpha signalling pathway
Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein.
cytoplasmic inclusion
An arrangement of closely apposed microtubules running parallel to each other.
microtubule fascicle
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.
extracellular fibril organisation
extracellular fibril organization
extracellular fibril organization and biogenesis
fibril organisation
fibril organization
The dormancy process that results in exit from dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated.
release from dormancy
A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon.
basilar dendrite
A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum.
dense material
A prolongation or process extending from the soma of an astrocyte and wrapping around neurons.
astrocyte process
peripheral astrocyte process
vellous process
Terminal process of astrocyte abutting non-neuronal surfaces in the brain.
astrocyte endfoot
An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.
ER-associated glycoprotein degradation
glycoprotein ERAD
gpERAD
misfolded or incompletely synthesized glycoprotein catabolic process
Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
PCD in response to oxidative stress
PCD in response to reactive oxygen species
programmed cell death in response to oxidative stress
reactive oxygen species-mediated PCD
reactive oxygen species-mediated programmed cell death
Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm.
synapsis fasciolaris
Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location.
establishment and maintenance of synaptic vesicle localization
establishment and maintenance of synaptic vesicle position
synaptic vesicle localisation
The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
neurite guidance
neuron process guidance
neuron protrusion guidance
neuronal cell projection guidance
A process in which a protein is transported to, or maintained in, a location within a non-motile cilium.
protein localization to nonmotile primary cilium
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus.
response to excess metal ion
response to metal ion stress
response to metal ion toxicity
response to metal toxicity
DNA N-glycosylase activity acting on deaminated bases.
deaminated base DNA glycosylase activity
DNA glycosylase activity acting on deaminated bases
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
response to acid stress
stress response to acid
The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage.
lymphoid lineage restricted progenitor cell migration
The movement of a lymphoid lineage cell (also called a lymphoid lineage restricted progenitor cell) into the thymus. Lymphoid lineage cells enter and exit the thymus several times as part of this process.
lymphoid lineage restricted progenitor cell migration into thymus
The process in which the thymus epithelium is generated and organized.
thymic epithelium morphogenesis
Part of the axoneme consisting of the inner two microtubule doublets of the 9+2 axoneme occurring in most motile cilia.
axonemal microtubule central pair
axoneme central pair
axoneme microtubule central pair
central pair
central-pair microtubules
A cellular anatomical entity that is part of an axoneme consisting of a doublet microtubule.
axonemal outer doublet
axoneme outer doublet
DMT
outer doublet
outer-doublet microtubules
The repair of double-strand breaks in mitochondrial DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
mtDSB repair
A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore.
calcium transmembrane import into cytosol
cytosolic calcium ion transport
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the left anterior basal body, extends laterally through the cytoplasm, crosses the right anterior axoneme, and exits as a membrane-bound flagellum on the anterior left side of the cell.
left anterior cilium
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the right anterior basal body, extends laterally through the cytoplasm, crosses the left anterior axoneme, and exits as a membrane-bound flagellum on the anterior right side of the cell.
right anterior cilium
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the left anterior boundary of the lateral shield and the left lateral region of the funis before exiting at the left lateral region of the cell body.
left posteriolateral cilium
left posterolateral cilium
left posterolateral flagellum
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the right anterior boundary of the lateral shield and the right lateral region of the funis before exiting at the right lateral region of the cell body.
right posteriolateral cilium
right posterolateral cilium
right posterolateral flagellum
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left ventral basal body and exits the cell body proximally and dorsal to the ventral disc.
left ventral cilium
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right ventral basal body and exits the cell body proximally and dorsal to the ventral disc.
right ventral cilium
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body.
left caudal cilium
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body.
right caudal cilium
The process of binding or confining iron ions such that they are separated from other components of a biological system.
iron ion retention
iron ion sequestering
iron ion sequestration
iron ion storage
retention of iron ion
sequestration of iron ion
storage of iron ion
The process of binding or confining copper ions such that they are separated from other components of a biological system.
copper ion retention
copper ion sequestering
copper ion sequestration
copper ion storage
retention of copper ion
sequestration of copper ion
storage of copper ion
Specialized organelle found in Giardia species (trophozoite stage) and characterized by a spiral array of microtubules and microtubule-associated structures including dorsal microribbons and crossbridges. The edge of the ventral disc narrows into a lateral crest. The ventral disk mediates mechanical attachment of the trophozoite to the host's intestinal wall, and contains the contractile proteins actinin, alpha-actinin, myosin, and tropomyosin working towards contraction of the disk involved in adherence.
adhesive disc
ventral adhesive disc
ventral disk
Catalysis of the hydrolysis of xylans, homopolysaccharides composed of xylose residues.
xylosidase activity
Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism).
heat-activated ion channel activity
temperature gated ion channel activity
temperature-activated ion channel activity
temperature-dependent ion channel activity
A furrow that may be found on the cell surface. Examples include the cingulum and sulcus found in some dinoflagellates.
cell surface groove
furrow
groove
A cell surface furrow that occurs on the ventral side of a dinoflagellate cell. It partially houses the longitudinal flagellum. The sulcus intersects with the cingulum on the ventral side of a dinoflagellate cell.
longitudinal furrow
longitudinal groove
sulcus
The part of a dinoflagellate cell above the cingulum; also referred to as the anterior portion of a dinoflagellate cell. It is separated from the hypocone by the cingulum.
epicone
episome
epitheca
The part of a dinoflagellate cell below the cingulum; also referred to as the posterior portion of a dinoflagellate cell. It is separated from the epicone by the cingulum.
hypocone
hyposome
hypotheca
The process in which an organism effects a change in the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
modulation by host of bacterial type IV pilus-dependent motility
The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.
potassium export
potassium export across plasma membrane
potassium ion export
potassium ion export from cell
Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.
low affinity basic amino acid transmembrane transporter activity
The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol.
arginine import
L-arginine import into cell
The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol.
L-lysine import into cell
A G protein-coupled receptor signaling pathway initiated by an extracellular member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
calcitonin family receptor signalling pathway
A G protein-coupled receptor signaling pathway initiated by amylin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
amilyn receptor signalling pathway
A protein complex that contains G protein-coupled receptors.
G-protein coupled receptor complex
A complete microtubule with 13 protofilaments that fuses with an incomplete microtubule called B tubule (containing 10 protofilaments only) to form an axonemal outer doublet. Inner and outer dynein arms, as well as the radial spoke, are attached to the A tubule.
A tubule
A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol , phosphatidylinositol-4-phosphate  and phosphatidylinositol-4,5-bisphosphate , and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast.
class I phosphatidylinositol 3-kinase complex
class I PI3K complex
The anterior most point of a dinoflagellate epicone.
apex
The anterior most point of a dinoflagellate hypocone.
antapex
The neurotransmitter-gated ion channel clustering process in which glutamate receptors are localized to distinct domains in the cell membrane.
glutamatergic receptor clustering
The directed movement of RNA to a specific location in the telomeric region of a chromosome.
establishment of RNA localisation to telomere
The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome.
establishment of macromolecular complex localisation to telomere
establishment of macromolecular complex localization to telomere
An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.
kinase activated-STAT cascade
kinase-STAT cascade
receptor signaling pathway via STAT
STAT signalling pathway
Any response to fluid shear stress in a vascular endothelial cell.
blood vessel endothelial cell response to fluid shear stress
A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes.
iron-dependent programmed cell death
Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression.
calcineurin signaling
calcineurin-mediated signalling
Any process involved in the controlled movement of a sperm cell.
sperm movement
Any process involved in the controlled movement of an amoeboid sperm cell.
ameboid sperm motility
ameboid sperm movement
amoeboid sperm movement