NothingMuch/GO-Terms huggingface dataset:
A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity.
R2TP/prefoldin-like complex
Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex.
OMP complex
The regionalization process that gives rise to the patterning of the ground tissue.
ground tissue patterning
A protein complex that is involved in the MEP pathway of IPP biosynthesis. It catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
1-deoxy-D-xylulose 5-phosphate reductoisomerase complex
The process of DNA recombination occurring within a single chromosome.
intrastrand DNA recombination
A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the core subunits of all TRAPP complexes in yeast.
TRAPP core complex
A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis.
PCMC
A tissue homeostatic process involved in the maintenance of an internal equilibrium within cartilage, including control of cellular proliferation and death and control of metabolic function.
negative regulation of cartilage homeostasis
positive regulation of cartilage homeostasis
regulation of cartilage homeostasis
Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity.
beta-phenylethylamine receptor activity
A protein complex involved in inactivating the function of DnaA and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of the beta clamp (DnaN) and Hda.
Hda-DnaN complex
Hda-dpo3b complex
Catalysis of the reaction: a  + coenzyme M = methyl-coenzyme M + a  + H+.
methanol-specific methylcobalamin: coenzyme M methyltransferase activity
methanol-specific methylcobalamin:coenzyme M methyltransferase activity
methanol-specific methylcobalamin:CoM methyltransferase activity
methylcobamide:coenzyme M methyltransferase activity
methylcobamide:CoM methyltransferase activity
A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle.
SeqA-dsDNA complex
SeqA-hemimethylated DNA complex
SeqA-hemimethylation dsDNA complex
A protein complex containing homohexameric DNA helicase DnaB, and the DNA helicase loader DnaC. The helicase loader DnaC delivers DnaB to the chromosomal origin (oriC).
DnaB6-DnaC3 complex
DnaB6-DnaC6 complex
helicase-loading complex
A protein-DNA complex containing the initiator protein DnaA bound to high-affinity recognition sites in the unique origin of replication, oriC. DnaA-oriC binding is the first step in assembly of a bacterial pre-replicative complex (pre-RC) and is responsible for the timely initiation of replication once per cell cycle.
DnaA-DNA complex
A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA.
DnaA-DiaA-DNA complex
A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC.
DnaA-HU-DNA complex
Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + -C-terminal Gly-NH-CH2-C(O)SH = 2-ethyl phosphate + -C-terminal Gly-Gly + 2 H+ + 2 H2O.
1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity
The recognition and rejection of pollen of one species by cells in the stigma of another species.
unilateral interspecific incompatibility
A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins.
ribosome quality control complex
ribosome-bound quality control complex
The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase I complex.
DNA-directed RNA polymerase I complex assembly
RNA Polymerase I complex assembly
The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex.
DNA-directed RNA polymerase II, core complex assembly
RNA Polymerase II assembly
The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex.
DNA-directed RNA polymerase III complex assembly
RNA Polymerase III complex assembly
An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell.
B cell receptor extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway via B cell antigen receptor
extrinsic apoptotic signaling pathway via BCR
Binds to and stops, prevents or reduces the activity of an RNA helicase.
ATP-dependent RNA helicase inhibitor activity
A multimer of H-NS proteins that is involved in bacterial nucleoid condensation and negative regulation of global gene expression by directly binding to promoter regions. Recognizes both structural and sequence-specific motifs in double-stranded DNA and has binding preference for bent DNA.
DNA-binding protein H-NS complex
histone-like protein H-NS complex
A homotetrameric protein complex consisting of a symmetrical pair of DiaA homodimers. Facilitates DnaA binding to the origin of replication during replication initiation.
DiaA homotetramer
A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
IML1 complex
SEACIT complex
A heterotetrameric protein complex which adenylates two molecules of the sulfur carrier subunit of the molybdopterin cofactor synthase using ATP as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoeB and MoaD; in human the subunits are MOCS3 and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved.
molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex
MPT adenylyltransferase complex
Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.
9-lipoxygenase activity
9S-lipoxygenase activity
linoleate 9-lipoxygenase activity
linoleate:oxygen 9S-oxidoreductase activity
Catalysis of the reaction: RH + ROOH = ROH + ROH.
peroxygenase activity
plant seed peroxidase activity
A heterotetrameric protein complex that catalyses sulfur transfer from the sulfur carrier subunit of molybdopterin synthase to precursor Z to synthesize molybdopterin as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoaE and MoaD; in human, MOCS2B and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved.
molybdopterin cofactor (Moco) biosynthesis sulfurtransferase complex
molybdopterin converting factor complex
MPT synthase complex
A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway.
CoA-SPC
coenzyme A-synthesizing protein complex
A homomeric protein complex that possesses glutamate dehydrogenase activity. This complex is evolutionarily conserved except that the number of homoprotomers per complex varies.
dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) complex
glutamate dehydrogenase (NADP+) complex
glutamic acid dehydrogenase complex
glutamic dehydrogenase complex
L-glutamate dehydrogenase complex
L-glutamate:NADP+ oxidoreductase (deaminating) complex
L-glutamic acid dehydrogenase complex
NAD(P)-glutamate dehydrogenase complex
NAD(P)H-dependent glutamate dehydrogenase complex
A homodimeric, extracellular protein complex containing two VEGF-A monomers. Binds to and activates a receptor tyrosine kinase.
vascular endothelial growth factor A complex
A process in which a protein is maintained in a location in telomeric heterochromatin.
maintenance of protein localisation to heterochromatin
maintenance of protein location in heterochromatin
A protein complex consisting of the pentameric maltose transporter complex bound to two enzyme IIA (EIIA) molecules. EIIA is a component of the glucose-specific phosphotransferase system that inhibits maltose transport from the periplasm to the cytoplasm. When EIIA-bound, the maltose transporter remains in the open, inward-facing conformation, which prevents binding of maltose-loaded maltose binding protein (MBP) to the transporter.
EIIA(Glc)-MalFGK2 complex
EIIA(Glc)-maltose transporter complex
maltose transporter inhibitor complex
The aggregation, arrangement and bonding together of a set of components to form a Dsc E3 ubiquitin ligase complex, an E3 ubiquitin ligase complex localized to the ER and Golgi membrane.
Dsc complex assembly
A protein complex containing homohexameric DnaB helicase, and DnaG (a primase). Facilitates the unwinding of double-stranded DNA and the synthesis of RNA primer sequences during DNA replication and repair in Prokaryotes.
DnaB-DnaG primosome complex
A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriB, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired.
DnaB-DnaC-DnaT-PriA-PriB preprimosome
phi-X174-type preprimosome
A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired.
DnaB-DnaC-DnaT-PriA-PriC preprimosome
phi-X174-type preprimosome
A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins Rep and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired.
DnaB-DnaC-Rep-PriC preprimosome
phi-X174-type preprimosome
A homohexameric protein complex that possesses DNA helicase activity; functions during DNA replication and repair.
DnaB hexamer
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein.
histone deacetylase activity (H3-K4 specific)
histone H3-K4 deacetylase activity
histone H3K14 deacetylase activity
Binding to damaged DNA containing single-strand breaks (SSBs).
single-strand break-containing damaged DNA binding
SSB-containing DNA binding
Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred.
protein localisation to site of double-strand break
protein localization to double-strand break site
protein localization to site of DSB
The chemical reactions and pathways resulting in the breakdown of a G protein-coupled receptor.
G-protein coupled receptor catabolic process
Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA.
G(5\')pppN pyrophosphatase activity
Protein complex involved in maltose transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of a cytoplasmic ATPase MalK homodimer together with a heterodimeric transmembrane subunit MalF-MalG.
MalF-MalG-MalK(2) complex
MalF-MalG-MalK-MalK complex
MalFGK(2) complex
maltose transport complex, core subunit
maltose transport MalFGK2 complex
A protein-DNA complex containing IHF heterodimers (an alpha and a beta chain) bound to DNA. IHF binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure, the bacterial nucleoid.
IHF complex
IHFa-IHFb-DNA complex
A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure.
HU complex
The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion.
tRNA 3\' processing in mitochondria
tRNA 3\' processing in mitochondrion
tRNA 3\'-end processing in mitochondria
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA.
acetyl-CoA anabolism from pantothenate
acetyl-CoA formation from pantothenate
acetyl-CoA synthesis from pantothenate
Protein complex facilitating ATP-dependent cobalamin (vitamin B12) transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic cobalamin-binding protein (BtuF), an integral membrane homodimer, BtuC, and a cytoplasmic ATP-binding homodimer BtuD.
BtuCDF complex
cobalamin-transporting BtuCDF complex
vitamin B12 transport complex
vitamin B12-transporting BtuCDF complex
Protein complex involved in cobalamin (vitamin B12) transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of the cytoplasmic ATPase BtuD homodimer together with the transmembrane BtuC homodimer.
BtuC-BtuD complex
cobalamin transport complex, core subunit
vitamin B12 transport complex, core subunit
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic U snRNP body.
U body assembly
The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC.
macrolide transporter MacAB-TolC complex
An ATP-binding cassette (ABC) transporter complex that is capable of methionine-importing activity. An example is the bacterial MetNIQ methionine transporter, that consists of the dimeric ATPase subunit MetN located at the cytoplasmic side of the plasma membrane and the dimeric transmembrane subunit MetI. MetQ is regarded as the periplasmic methionine-binding chaperon subunit, and is capable of transporting methionine from the periplasm into the cytoplasm in an ATP-dependent manner.
ATP-binding cassette (ABC) methionine importer complex
ATP-dependent methionine importer complex
ATP-dependent methionine importing complex
ATP-dependent methionine-importing complex
methionine transport complex
methionine transporter
methionine transporter complex
methionine transporter complex, ATP-dependent
MetNI complex
MetNI transport complex
MetNI transporter
MetNI transporter complex
MetNIQ complex
MetNIQ transport complex
MetNIQ transporter
MetNIQ transporter complex
A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism.
ModE dimer
An ATP-binding cassette (ABC) transporter complex made up of a dimer of MsbA. Facilitates the export across the plasma membrane of, amongst others, lipid A and lipopolysaccharide. In contrast to most ABC transporter complexes, each chain of the homodimer contains both the transmembrane domain (TMD) and the cytoplasmic ATP-binding domain (NBD).
MsbA complex
MsbA dimer
A protein complex containing an alkanesulfonate monooxygenase subunit (SsuD tetramer in E.coli) and a flavin oxidoreductase subunit (SsuE dimer in E.coli). Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation.
two-component alkanesulfonate monooxygenase system
A protein complex capable of alkanesulfonate monooxygenase activity. Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation, catalyzing the conversion of alkanesulfonates into aldehydes and sulfite. In E.coli the complex consists of a SsuD tetramer.
SsuD complex
A protein complex capable of FMN reductase activity. Reduces FMN to FMNH2 in a NAD(P)H-dependent manner. In E.coli, consists of a SsuE dimer.
flavin oxidoreductase complex, NAD(P)H-dependent
FMN oxidoreductase complex, NAD(P)H-dependent
FMN reductase complex, NAD(P)H-dependent
SsuE complex
A protein complex containing two transmembrane subunits; a MdtB dimer and one unit of MdtC. Capable of exporting substrates across the cell membrane. Involved in conferring antibiotic resistance of Gram-negative bacteria by transporting drugs across the membrane.
multidrug efflux pump MdtBC
A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD.
2-aminoethanesulfonate dioxygenase complex
alpha-ketoglutarate-dependent taurine dioxygenase complex
TauD complex
Catalysis of the reaction: jasmonyl-Ile + H2O = jasmonic acid + L-isoleucine.
JA-Ile hydrolase
A transmembrane protein complex capable of transporting positively charged hydrophobic drugs across the plasma membrane thereby involved in conferring resistance to a wide range of toxic compounds (e.g. methyl viologen, ethidium bromide and acriflavine). It is commonly found in bacteria. In E. coli it forms a homodimer.
EmrE complex
A process in which a symbiont initiates, promotes, or enhances transcription of genes into mRNA in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
positive regulation by symbiont of host transcription
Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of phytoalexin production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
negative regulation by symbiont of host phytoalexin production
Bacterial chaperonin complex consisting of a heptameric 10kDa chaperonin subunit GroES and a tetradecameric (2x7) 60kDa chaperonin subunit GroEL. The 60kDa subunit possesses ATPase activity while the holo-enzyme is responsible for the correct folding of proteins.
bacterial chaperonin ATPase complex
bacterial chaperonin complex
The ProVWX complex belongs to the family of ATP-binding cassette (ABC) transporter proteins complexes. It consists of a cytoplasmic ATPase subunit ProV, a transmembrane subunit ProW and a periplasmic binding protein ProX. It is capable of translocating a wide variety of solute (e.g. glycine betaine) across the plasma membrane and is activated under osmotic stress conditions.
ATP-binding cassette (ABC) transporter complex ProVWX
Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate.
beta-nicotinamide D-ribonucleotide phosphatase activity
nicotinamide mononucleotide phosphatase activity
The maintenance of a paranodal junction, a highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. A paranodal junction flanks the node of Ranvier in myelinated nerve, electrically isolates the myelinated from unmyelinated nerve segments, and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.
axoglial septate junction maintenance
paranodal axoglial junction maintenance
paranodal septate maintenance
A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor), which may be a target protein or another Fe-S assembly complex. In humans, it consists of HSPA9, HSCB, GLRX5, ABCB7 and GFER.
Fe-S cluster transfer complex
IscA complex
SufA complex
SufA dimer
A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response.
stimulator of interferon genes complex
A protein complex capable of phosphomannomutase activity.
PMM-1 complex
PMM-1 dimer
PMM-2 complex
PMM-2 dimer
A protein complex which is capable of diamine N-acetyltransferase activity.
SAT complex
SAT tetramer
spermidine acetyltransferase complex
Catalysis of the reaction: histone H2A-threonine (position 120) + ATP = histone H2A-phosphothreonine (position 120) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 120 of histone H2A.
histone H2A-T120 kinase activity
histone kinase activity (H2A-T120 specific)
histone threonine kinase activity (H2A-T120 specific)
A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.
mitochondrial uniporter complex
mitochondrial uniporter holocomplex
A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs.
N6-methyladenosine-containing RNA binding
An nuclear body involved in nuclear mRNA surveilllance. Contains at least Mmi1, or an ortholog of it, and the nuclear exosome.
Mmi1 nuclear focus
nuclear body
A protein complex that contributes to the endocytic process and bud growth in yeast. It is involved in the precise timing of actin assembly during endocytosis.
Syp1 dimer
Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response.
ligand clustering
A cytoplasmic dense-core vesicle that transports a range of proteins including piccolo, bassoon, N-cadherin and syntaxin. The transported proteins may be associated with the external side of the vesicle, rather than being contained within the vesicle, therefore forming an aggregate of vesicle and proteins. Piccolo-bassoon transport vesicles (or PTVs) range in size from approximately 80 nm in diameter for dense core vesicles to 130 nm by 220 nm in area for aggregates. They are packaged via the trans-Golgi network before being transported through the axon.
PTV