NothingMuch/GO-Terms huggingface dataset:
A process in which a symbiont inhibits or disrupts the formation of neutrophil extracellular traps by the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated perturbation of host neutrophil extracellular trap formation
symbiont-mediated suppression of host neutrophil extracellular traps formation
Catalysis of the reaction: NAD+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADH.
alpha-glycerol phosphate dehydrogenase (NAD) activity
alpha-glycerophosphate dehydrogenase (NAD) activity
glycerol 1-phosphate dehydrogenase activity
glycerol phosphate dehydrogenase (NAD) activity
glycerol-3-phosphate dehydrogenase (NAD) activity
glycerol-3-phosphate dehydrogenase  activity
glycerophosphate dehydrogenase (NAD) activity
hydroglycerophosphate dehydrogenase activity
L-alpha-glycerol phosphate dehydrogenase activity
L-alpha-glycerophosphate dehydrogenase activity
L-glycerol phosphate dehydrogenase activity
L-glycerophosphate dehydrogenase activity
NAD-alpha-glycerophosphate dehydrogenase activity
NAD-dependent glycerol phosphate dehydrogenase activity
NAD-dependent glycerol-3-phosphate dehydrogenase activity
NAD-L-glycerol-3-phosphate dehydrogenase activity
NAD-linked glycerol 3-phosphate dehydrogenase activity
NADH-dihydroxyacetone phosphate reductase activity
NADP+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADPH.
glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity
glycerol-3-phosphate dehydrogenase  activity
L-glycerol-3-phosphate:NADP oxidoreductase activity
Any process that stops, prevents or reduces the frequency, rate or extent of cAMP/PKA signal transduction.
negative regulation of cAMP/PKA signaling
Any process that activates or increases the frequency, rate or extent of cAMP/PKA signal transduction.
positive regulation of cAMP/PKA signaling
An epigenetic cytosine DNA demethylation pathway that starts with the enzymatic oxidation of the 5-methylcytosine (5meC) to generate 5-hydroxymethylcytosine (5hmC), which successively converted to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC).  A DNA glycosylase (e. g. TDG) recognizes the  intermediate bases 5fC and 5caC and excises the modified base to initiate its replacement with unmethylated cytosine through base excision repair.
epigenetic 5-methylcytosine DNA demethylation, oxidation pathway
epigenetic DNA demethylation, oxidation pathway
An epigenetic cytosine DNA demethylation pathway that includes a deamination step to produce either a thymine (T), or a 5-hydroxymethyluracil (5hmU), if the 5meC had first been converted to 5hmC. A DNA glycosylase (e. g. TDG) recognizes the T mispaired with a G or the 5hmC and excises the modified base to initiate its replacement with unmethylated cytosine through base excision repair.
epigenetic 5-methylcytosine DNA demethylation, oxidative deamination pathway
epigenetic DNA demethylation, oxidative deamination pathway
A process by which a symbiont inhibits or disrupts pro-inflammatory cytokine signaling in the host organism, either by disruption of production, sequesteration, or destruction of at least one component of the signaling pathway. Pro-inflammatory cytokines include: IL-1, IL-12, IL-18, TNF, IFN-gamma, and GM-CSF. The host is defined as the larger of the organisms involved in a symbiotic interaction.
negative regulation by symbiont of host pro-inflammatory cytokine production
suppression by symbiont of host pro-inflammatory cytokine production
suppression by symbiont of host pro-inflammatory cytokine secretion
symbiont-mediated degradation of host pro-inflammatory cytokine
symbiont-mediated sequestering of host pro-inflammatory cytokine
symbiont-mediated suppression of host pro-inflammatory cytokine production
A process by which a symbiont inhibits or disrupts anti-inflammatory cytokine signaling in the host organism, either by disruption of production, sequesteration, or destruction of at least one component of the signaling pathway.  Anti-inflammatory cytokines include: interleukin (IL)-1, IL-4, IL-6, IL-10, IL-11, and IL-13. The host is defined as the larger of the organisms involved in a symbiotic interaction.
negative regulation by symbiont of host anti-inflammatory cytokine production
suppression by symbiont of host anti-inflammatory cytokine production
suppression by symbiont of host anti-inflammatory cytokine secretion
symbiont-mediated degradation of host anti-inflammatory cytokine
symbiont-mediated sequestering of host anti-inflammatory cytokine
symbiont-mediated suppression of host anti-inflammatory cytokine production
A process by which a symbiont avoids the effects of recognition by host  complement by altering molecules on the symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated evasion of host complement
A molecular adaptor recognizes and binds a target protein containing a UFM1 modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.
UFM1 modified protein reader activity
UFM1-dependent protein binding
A G protein-coupled receptor signaling pathway that starts with an opsin molecule being activated by a photon. Opsins include rhodopsin and others visual receptors bind heterotrimeric transducin G proteins upon activation. Activated transducin alpha-subunit activates cGMP phosphodiesterase, which breaks down cGMP. The decrease in cGMP concentration leads to closure of cGMP-gated (CNG) channels, blockage of Na+ influx, and hyperpolarization of photoreceptor plasma membrane, leading to transmission of signal through synapses. The signal is terminated by phosphorylation of the C-terminal tail of rhodopsin by rhodopsin kinase to allow arrestin to bind and block G protein binding. Typical examples are rhabdomeric photoreceptors in the eyes of deuterostomes.
cGMP-mediated opsin signaling pathway
cGMP-mediated rhodopsin signaling pathway
ciliary opsin-mediated signaling pathway
cyclic-GMP-mediated opsin signaling pathway
cyclic-nucleotide-mediated opsin signaling pathway
Gt-mediated opsin signaling pathway
Catalysis of the reaction: 2 ATP + H+ = diphosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate.
adenine triphosphate adenylyltransferase activity
A transposable element silencing mechanism mediated by Piwi-associated RNA (piRNA)-directed DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription.
retrotransposon silencing by piRNA-directed DNA methylation
transposable element silencing by piRNA-directed DNA methylation
Catalysis of the reaction: (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H+ + H2O + oxidized  = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced .
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity
A process by which a symbiont prevents host complement activation by recruiting host proteases, destroying the complement before it has its effect on the symbiont.
symbiont-mediated suppression of host complement activation by recruitment of host proteases
The directed movement of dipeptide from the lysosomal lumen across the lysosomal membrane and into the cytosol.
dipeptide export from lysosomal lumen
dipeptide export from lysosome
transmembrane dipeptide transport from lysosomal lumen to cytosol
Catalysis of the reaction: lactate + ATP + L-lysyl- = N(6)-lactoyl-L-lysyl-+ AMP + diphosphate. Can also act on free lactate.
peptide lactyltransferase (ATP dependent) activity
peptide lactyltransferase activity
Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl- + NAD = L-lysyl- + nicotinamide +2''-O-lactoyl-ADP-D-ribose, transfering a lactoyl group attached to a lysine residue in a protein to NAD.
protein lysine delactylase activity
A nuclear receptor-mediated signaling pathway initiated by an oxysterol binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
intracellular oxysterol receptor signaling pathway
nuclear receptor-mediated oxysterol signaling pathway
Any process that activates or increases the frequency, rate or extent of phospholipase C/protein kinase C signal transduction.
positive regulation of PLC/PKC signal transduction
The posttranscriptional addition of a carbohydrate or carbohydrate derivative unit to residues in an RNA molecule.
glycoRNA biosynthesis
Endocytosis of large regions of presynaptic membrane after intense stimulation-mediated fusion of multiple synaptic vesicles. Bulk endocytosis is triggered by high loads of membrane addition through exocytosis of synaptic vesicles and elevated concentration of calcium in the presynapse.
activity-dependent bulk endocytosis
activity-dependent bulk synaptic vesicle endocytosis
ADBE
bulk endocytosis
Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches.
positive regulation of neurite arborization
positive regulation of neurite branching
positive regulation of neuron projection branching
Any process that stops, prevents or reduces the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches.
negative regulation of neurite arborization
negative regulation of neurite branching
negative regulation of neuron projection branching
The process in which an oxidised low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
ox-LDL particle clearance
oxidised LDL particle clearance
oxidized LDL particle clearance
oxidized low-density lipoprotein particle clearance
oxLDL particle clearance
Combining with an oxidised low-density lipoprotein particle and delivering the oxidised low-density lipoprotein particle into the cell via endocytosis.
ox-LDL particle receptor activity
ox-LDL receptor activity
oxidised LDL particle receptor activity
oxidised LDL receptor activity
oxidised low-density lipoprotein receptor activity
oxidized LDL particle receptor activity
oxidized LDL receptor activity
oxidized low-density lipoprotein particle receptor activity
oxidized low-density lipoprotein receptor activity
oxLDL particle receptor activity
oxLDL receptor activity
The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.
extra-synaptic extracellular matrix structural constituent
structural constituent of extra-synaptic extracellular matrix
synapse-associated extracellular matrix structural constituent
G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential.
G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum.
cerebellar parallel fiber to Purkinje cell synapse
The network of the Golgi apparatus structures located within the postsynapse.
Golgi outpost
A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata.
cerebellar climbing fibre to Purkinje cell synapse
A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 1. Amylin receptor complex 1 (AMY1) also serves as a receptor for the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM).
AMY1 complex
A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 2. Amylin receptor complex 2 (AMY2) also serves as a receptor for adrenomedullin (AM/ADM).
AMY2 complex
A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 3. Amylin receptor complex 3 (AMY3) also serves as a receptor for the amyloid-beta complex. Ligand binding to AMY3 results in increased cytosolic calcium ion levels and in activation on multiple intracellular signaling pathways.
AMY3 complex
The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 1 (AMY1), a G protein-coupled receptor complex, on the surface of the target cell. Other ligands that have been shown to initiate the AMY1 signaling pathway include the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM).
AMY1 signaling pathway
The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 2 (AMY2), a G protein-coupled receptor complex, on the surface of the target cell. The AMY2 signaling pathway can also be initiated by adrenomedullin (AM/ADM).
AMY2 signaling pathway
The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 3 (AMY3), a G protein-coupled receptor complex, on the surface of the target cell. The AMY3 signaling pathway can also be initiated by the amyloid-beta complex. AMY3 signaling results in increased import of calcium ions into the cytosol across plasma membrane, increased phosphorylation of ERK1/2, Act, and a PKA regulatory subunit II, as well as increased expression of cFos.
AMY3 signaling pathway
Synaptic pruning mediated by complement system signaling.
complement-dependent synapse pruning
synapse clearance
synapse disassembly
synapse elimination
synapse removal
Early postnatal vertebrate developmental process, during which axons of retinal ganglion cells (RGCs), transmitting overlapping inputs from both eyes, segregate into distinct eye-specific non-overlapping regions in the dorsal lateral geniculate nucleus (dLGN) of the thalamus.
binocular vision development
eye-specific patterning
eye-specific segregation
vertebrate eye-specific segregation
A single axon terminal bouton making contact onto two or more dendritic spines protruding from the same dendrite.
MSB1
type 1 multi-synapse bouton
type 1 multi-synaptic bouton
type 1 multiple spine synapse bouton
type 1 multiple-synapse bouton
type 1 multisynapse bouton
type 1 multisynaptic bouton
A single axon terminal bouton making contact onto two or more dendritic spines protruding from multiple dendrites.
MSB2
type 2 multi-synapse bouton
type 2 multi-synaptic bouton
type 2 multiple spine synapse bouton
type 2 multiple-synapse bouton
type 2 multisynapse bouton
type 2 multisynaptic bouton
A process that modulates synaptic scaling. Synaptic scaling is a form of synaptic plasticity, which entails uniform adjustments in the strength of all synapses on a cell in response to prolonged changes in the electrical activity of the cell.
homeostatic synaptic scaling
regulation of homeostatic synaptic scaling
The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation.
amyloid-beta clearance by phagocytosis
Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine.
neuron-glia signaling
neuron-glia signalling
neuron-glial cell signalling
neurone-glia signaling
neurone-glia signalling
neurone-glial cell signaling
neurone-glial cell signalling
Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation.
repression of monocyte activation
A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells.
gliosis
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 production.
negative regulation of interleukin-33 biosynthetic process
negative regulation of interleukin-33 secretion
Any process that activates or increases the frequency, rate or extent of interleukin-33 production.
positive regulation of interleukin-33 biosynthetic process
positive regulation of interleukin-33 secretion
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 production.
negative regulation of interleukin-37 biosynthetic process
Any process that activates or increases the frequency, rate or extent of interleukin-37 production.
positive regulation of interleukin-37 biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of CD86 biosynthetic process.
negative regulation of CD86 biosynthetic process
Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process.
positive regulation of CD86 biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of CD80 biosynthetic process.
negative regulation of CD80 biosynthetic process
Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process.
positive regulation of CD80 biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17A production.
negative regulation of interleukin-17A biosynthetic process
Any process that activates or increases the frequency, rate or extent of interleukin-17A production.
positive regulation of interleukin-17A biosynthetic process
Any process that activates or increases the frequency, rate or extent of interleukin-34 production.
positive regulation of interleukin-34 biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 production.
negative regulation of interleukin-34 biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 production.
negative regulation of interleukin-32 biosynthetic process
negative regulation of interleukin-32 secretion
Any process that activates or increases the frequency, rate or extent of interleukin-32 production.
positive regulation of interleukin-32 biosynthetic process
positive regulation of interleukin-32 secretion
An endocytosis process mediated by the Fc receptor for the purpose of delivery of antigen-bound immunoglobulin to an intracellular compartment where the antigen can be processed and loaded onto MHC molecules. This process selectively targets antigens for presentation by MHC class II or cross-presentation by MHC class I.
antigen-antibody immune complex uptake via Fc receptor
Fc receptor-mediated immune complex internalization
Ig-complexed antigen endocytosis via Fc receptor
The controlled release of a substance by a cell or a tissue by discharging a portion of the secreting cell when intracellular components are freed into a lumen through the shedding of whole pieces of the cytoplasm.
secretion by cell decapitation
secretion by membrane budding
A reflex process that expels air forcibly from the mouth and nose in an explosive, spasmodic involuntary action resulting chiefly from irritation of the nasal mucous membrane.
sternutation
A sensory perception which causes the desire or reflex to scratch.
pruritus
Any process that decreases the frequency, rate or extent of a pyroptotic inflammatory response.
negative regulation of pyroptosis
The process in which an endoplasmic reticulum membrane is synthesized, aggregates, and bonds together.
ER membrane biogenesis
The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain.
somatosensory system development
A multilamellar subcellular structure formed in the cytoplasm of developing neuron, composed of Tmem240 and Emd proteins.
T240-body
A corepressor complex containing the WD-repeat protein Tup1p (S. cerevisiae) and Tup11/Tup12 (fission yeast) and the TPR repeat protein Cyc8p (S. cerevisiae) ssn6 (fission yeast) that is recruited to target genes by DNA-bound repressor proteins preferentially at regions where histones are deacetylated by the Clr6 class I HDAC, and recruits the SWI/SNF and SAGA complexes to promoters.
Tup11/Tup12 repressor complex
Cell death resulting from activation of endogenous cellular processes and occurring as a result of a retinoic acid.
retinoic acid-induced apoptosis
A protein complex that mediates the insertion of multi-pass transmembrane proteins into endoplasmic reticulum (ER) membrane. Substrates enter via the lateral gate of the Sec61 translocon. The complex comprises the GEL subcomplex (composed of RAB5IF/OPTI and TMCO1), the BOS subcomplex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT subcomplex (composed of WDR83OS/Asterix and CCDC47).
MPT complex
TMCO1 translocon
A SIN signaling complex associated with the old mitotic spindle pole body during interphase and early M-phase and characterised by the presence active ubiquitin ligase (Dma1 in fission yeast) and GTPase activator (Spg1 in fission yeast) to inactivate SIN signaling.
interphase SIN signalling complex
A SIN signaling complex associated with the new mitotic spindle pole body during anaphase and characterized by the presence activated (GTP bound) GTPase (Spg1 in fission yeast) to activate SIN signaling.
new spindle pole body SIN signalling complex
Any process that decreases the rate, frequency or extent of pollen tube guidance towards ovules. This is one mechanism to prevent polytuby, the simultaneous penetration of ovules by multiple pollen tubes.
prevention of polytuby
A homeostatic process involved in the maintenance of a steady state level of tetrahydroxoborate within a cell.
intracellular boron homeostasis
intracellular tetrahydroxoborate homeostasis
The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way.
core protein activity for the CUL-RING ubiquitin ligase complex
The aggregation, arrangement and bonding together of a set of components to form a Casparian strip, a region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material.
Casparian strip formation
Combining with glycine and transmitting the signal across the membrane by changing the activity of intracellular G protein signaling.
metabotropic glycine receptor activity
mGlyR
Catalysis of the reaction: 2-oxoglutarate + L-prolyl- + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-.
HIF hydroxylase
HIF prolyl hydroxylase
The process in which an activated T cell acquires specialized features of an exhausted T cell.
T cell dysfuction
T cell exhaustion
Catalysis of the reaction: guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine.
N(2),N(2)-dimethylguanosine tRNA methyltransferase
tRNA (guanine(10)-N(2))-dimethyltransferase activity
tRNA (guanosine(10)-N(2))-dimethyltransferase activity
Catalysis of the reaction: guanosine(10) in tRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine.
tRNA (guanine(10)-N(2))-methyltransferase activity
tRNA (guanosine(10)-N(2))-methyltransferase activity
Catalysis of the reaction: guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H+ + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine.
tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase activity
tRNA (guanosine(26)-N(2)/guanosine(27)-N(2))-dimethyltransferase activity