NothingMuch/GO-Terms huggingface dataset:
Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization.
activation of intermediate filament depolymerization
positive regulation of intermediate filament polymerization and/or depolymerization
stimulation of intermediate filament depolymerization
up regulation of intermediate filament depolymerization
up-regulation of intermediate filament depolymerization
upregulation of intermediate filament depolymerization
A G protein-coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).
G-protein-coupled inhibitory pathway of phospholipase C
GPCR signaling pathway coupled to inhibition of phospholipase C activity
GPCR signaling pathway via inhibition of PLC
inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway
phospholipase C inhibition
phospholipase C-inhibiting G-protein coupled receptor signaling pathway
PLC-inhibiting GPCR signaling pathway
The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end.
termination of RNA polymerase II transcription, poly(A)-independent
transcription termination from Pol II promoter, poly(A)-independent
transcription termination from Pol II promoter, RNA polymerase(A)-independent
Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH4 + oxaloacetate.
3-hydroxyaspartate dehydratase activity
L-threo-3-hydroxyaspartate dehydratase activity
threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)
threo-3-hydroxy-L-aspartate ammonia-lyase activity
threo-3-hydroxyaspartate dehydratase activity
Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation.
down regulation of polarized epithelial cell differentiation
down-regulation of polarized epithelial cell differentiation
downregulation of polarized epithelial cell differentiation
inhibition of polarized epithelial cell differentiation
Any process that activates or increases the rate or extent of polarized epithelial cell differentiation.
activation of polarized epithelial cell differentiation
stimulation of polarized epithelial cell differentiation
up regulation of polarized epithelial cell differentiation
up-regulation of polarized epithelial cell differentiation
upregulation of polarized epithelial cell differentiation
Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
MRN complex
MRX complex
Rad50 complex
RAD50-MRE11-NBN complex
Rad50-Rad32-Nbs1 complex
RMX complex
Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining.
ribosomal DNA protrusion
A protein complex composed of an alpha and a beta receptor subunit and an interleukin ligand. In human, Interleukin-19, -20 and -24 bind IL20RA/IL20RB receptor subunits and Interleukin-20 and -24 bind IL22RA1/IL20RB receptor subunits.
IL-20 receptor complex
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
23S APC complex
APC-Axin-1-beta-catenin complex
Axin-APC-beta-catenin-GSK3B complex
BDC
beta-catenin degradation complex
Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.
down regulation of myeloid dendritic cell activation
down-regulation of myeloid dendritic cell activation
downregulation of myeloid dendritic cell activation
inhibition of myeloid dendritic cell activation
Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation.
activation of myeloid dendritic cell activation
stimulation of myeloid dendritic cell activation
up regulation of myeloid dendritic cell activation
up-regulation of myeloid dendritic cell activation
upregulation of myeloid dendritic cell activation
Any process that stops, prevents or reduces the rate or extent of B cell proliferation.
down regulation of B cell proliferation
down-regulation of B cell proliferation
downregulation of B cell proliferation
inhibition of B cell proliferation
negative regulation of B lymphocyte proliferation
negative regulation of B-cell proliferation
negative regulation of B-lymphocyte proliferation
Any process that activates or increases the rate or extent of B cell proliferation.
activation of B cell proliferation
positive regulation of B lymphocyte proliferation
positive regulation of B-cell proliferation
positive regulation of B-lymphocyte proliferation
stimulation of B cell proliferation
up regulation of B cell proliferation
up-regulation of B cell proliferation
upregulation of B cell proliferation
A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.
pVHL-elongin C-elongin B complex
VHL complex
von Hippel-Lindau tumor suppressor complex
A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex.
nuclear mitotic cohesin complex
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
nuclear meiotic cohesin complex
Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP).
apoB mRNA editing enzyme complex
APOBEC
Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage.
CCC
Rad9-Hus1-Rad1 (9-1-1) clamp complex
The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodeling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6.
heterodimeric membrane-deforming retromer subcomplex
retromer complex, outer shell
SNX-BAR dimer
The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals.
cargo-selective retromer subcomplex
retromer complex, inner shell
retromer CSC
retromer, cargo recognition complex
retromer, CRC
A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi6p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p.
DSC1 transcription factor complex
MBF
Mlu1-box binding factor
Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices.
tetratricopeptide repeat domain binding
Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier.
paranodal axoglial junction formation
paranodal junction biosynthesis
paranodal junction formation
Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.
ER signal peptide binding
Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion.
mitochondrial targeting sequence binding
Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
down regulation of vascular endothelial growth factor receptor signaling pathway
down-regulation of vascular endothelial growth factor receptor signaling pathway
downregulation of vascular endothelial growth factor receptor signaling pathway
inhibition of vascular endothelial growth factor receptor signaling pathway
negative regulation of vascular endothelial growth factor receptor signalling pathway
negative regulation of VEGF receptor signaling pathway
negative regulation of VEGF receptor signalling pathway
Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
activation of vascular endothelial growth factor receptor signaling pathway
positive regulation of vascular endothelial growth factor receptor signalling pathway
positive regulation of VEGF receptor signaling pathway
positive regulation of VEGF receptor signalling pathway
stimulation of vascular endothelial growth factor receptor signaling pathway
up regulation of vascular endothelial growth factor receptor signaling pathway
up-regulation of vascular endothelial growth factor receptor signaling pathway
upregulation of vascular endothelial growth factor receptor signaling pathway
Binding to a potassium ion (K+).
K ion binding
A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms.
AdT
GatCAB
GatFAB
Binding to a molybdate ion (MoO4 2-).
MoO4 ion binding
Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
thiamin binding
vitamin B1 binding
Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.
aneurine pyrophosphate binding
cocarboxylase binding
diphosphothiamin binding
thiamin pyrophosphate binding
TPP binding
The chemical reactions and pathways resulting in the breakdown of alpha-glucans.
alpha-glucan breakdown
alpha-glucan catabolism
alpha-glucan degradation
A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime.
adventurous gliding movement
Binding to a kininogen of high molecular mass.
HK binding
HMW kininogen binding
Binding to a kininogen of low molecular mass.
LK binding
LMW kininogen binding
The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa.
IFT A complex
IFT complex A
intraflagellar transport complex A
intraflagellar transport particle A
The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa.
IFT B complex
IFT complex B
intraflagellar transport complex B
intraflagellar transport particle B
Dissolution of the primary septum during cell separation.
hydrolysis of primary cell septum
primary cell septum hydrolysis
primary septum hydrolysis
The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation.
cell septum edging hydrolysis
hydrolysis of cell septum edging
hydrolysis of edging of cell septum
septum edging hydrolysis
Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex.
Kdp system complex
Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
ABP-278/276 binding
ABP-280 binding
ABPL binding
alpha-filamin binding
beta-filamin binding
filamin A binding
filamin B binding
filamin C binding
filamin-1 binding
filamin-2 binding
filamin-3 binding
filamin-A binding
filamin-B binding
filamin-C binding
gamma-filamin binding
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity.
INO80 chromatin remodeling complex
An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates.
mitochondrial editosome
An mRNA editing complex found in a plastid.
plastid editosome
A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus.
iMTOC
interphase microtubule organising center
interphase MTOC
The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.
nuclear migration, microfilament-mediated
The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center.
interphase microtubule organising center biosynthesis
interphase microtubule organising center formation
interphase microtubule organizing center biogenesis
interphase microtubule organizing centre assembly
The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis.
equatorial microtubule organising center disassembly
Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling.
down regulation of septation initiation signaling
down-regulation of septation initiation signaling
downregulation of septation initiation signaling
inhibition of septation initiation signaling
negative regulation of septation initiation network
negative regulation of septation initiation signaling cascade
negative regulation of septation initiation signalling
Any process that activates or increases the frequency, rate or extent of septation initiation signaling.
activation of septation initiation signaling
positive regulation of septation initiation network
positive regulation of septation initiation signaling cascade
positive regulation of septation initiation signalling
stimulation of septation initiation signaling
up regulation of septation initiation signaling
up-regulation of septation initiation signaling
upregulation of septation initiation signaling
Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage.
chromosome breakage
Catalysis of the reaction: L-cysteine + -cysteine = L-alanine + -S-sulfanylcysteine.
cysteine desulfurylase activity
IscS
L-cysteine:enzyme cysteine sulfurtransferase activity
NIFS
SufS
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.
histone deacetylase activity (H3-K14 specific)
histone H3-K14 deacetylase activity
histone H3K14 deacetylase activity
A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).
Nup107-120 complex
Nup107-160 complex
Nup84 complex
The lipid bilayer surrounding the platelet alpha granule.
platelet alpha-granule membrane
The volume enclosed by the membrane of the platelet alpha granule.
platelet alpha-granule lumen
The chemical reactions and pathways resulting in the formation of holo-.
holo- biosynthesis
holo- anabolism
holo- biosynthesis
holo- formation
holo- synthesis
Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.
activation of microtubule depolymerization
microtubule destabilization
positive regulation of microtubule catastrophe
positive regulation of microtubule disassembly
stimulation of microtubule depolymerization
up regulation of microtubule depolymerization
up-regulation of microtubule depolymerization
upregulation of microtubule depolymerization
Catalysis of the reaction: L-serine + NADP+ = L-alpha-formylglycine + 2 H+ + NADPH.
L-serine:NADP+ 3-oxidoreductase activity
Any process in which the proteasome is transported to, or maintained in, a specific location.
establishment and maintenance of proteasome localization
proteasome localisation
The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells.
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one anabolism
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthesis
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthetic process
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one formation
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one synthesis
DIF-1 biosynthesis
The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development.
migratory slug development during sorocarp development
pseudoplasmodium biosynthesis
pseudoplasmodium formation
slug development during fruiting body development
slug development during sorocarp development
standing slug development during sorocarp development
Any process that decreases the size of the aggregate formed during sorocarp formation.
down regulation of aggregate size
down-regulation of aggregate size
downregulation of aggregate size
inhibition of aggregate size
Any process that increases the size of the aggregate formed during sorocarp formation.
activation of aggregate size
stimulation of aggregate size
up regulation of aggregate size
up-regulation of aggregate size
upregulation of aggregate size
Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O.
L-ornithine 5-monooxygenase activity
The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear.
otoconia mineralization
otoconium mineralization
Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.
1,4-beta-D-xylan xylanohydrolase activity
1,4-beta-xylan xylanohydrolase activity
beta-1,4-xylan xylanohydrolase activity
beta-1,4-xylanase activity
beta-D-xylanase activity
beta-xylanase activity
endo-(1,4)-beta-xylanase(1,4)-beta-xylan 4-xylanohydrolase activity
endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity
endo-1,4-beta-D-xylanase activity
endo-1,4-xylanase activity
endo-beta-1,4-xylanase activity
xylanase
The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex.
posttranslational protein membrane targeting, docking
posttranslational protein targeting to membrane, docking
protein docking during posttranslational protein targeting to membrane
Sec-translated protein complex assembly
A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p.
ER protein translocation subcomplex
Sec62/63 complex
Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.
broad-complex, tramtrack, and bric-a-brac domain binding
BTB domain
A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.
WAVE complex
WAVE regulatory complex
WRC
An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters).
remodeling and spacing factor complex
Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose).
pullulan 4-D-glucanohydrolase (panose-forming)
pullulanase II activity
Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units.
1,4-beta-D-glucan glucohydrolase activity
beta-1,4-beta-glucanase activity
beta-1,4-glucanase activity
exo-1,4-beta-D-glucosidase activity
exo-1,4-beta-glucanase activity
exo-1,4-beta-glucosidase activity
exo-beta-1,4-glucanase activity
exo-beta-1,4-glucosidase activity
exocellulase activity
Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans.
arabinogalactan 4-beta-D-galactanohydrolase activity
arabinogalactanase activity
endo-1,4-beta-galactanase activity
galactanase activity
Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units.
2,6-beta-D-fructan fructanohydrolase activity
levan hydrolase activity
The chemical reactions and pathways resulting in the breakdown of arabinan, a polysaccharide composed of arabinose residues.
arabinan breakdown
arabinan catabolism
arabinan degradation
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its periplasmic surface, but not integrated into the hydrophobic region.
extrinsic to external leaflet of plasma membrane, in periplasmic space
extrinsic to external side of plasma membrane, in periplasmic space
The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to periplasmic surface, but not integrated into the hydrophobic region.
extrinsic to internal leaflet of cell outer membrane
extrinsic to internal side of cell outer membrane
extrinsic to internal side of outer membrane
extrinsic to periplasmic side of cell outer membrane