NothingMuch/GO-Terms huggingface dataset:
A homeostatic process involved in the maintenance of a steady state level of threonine within a cell.
cellular threonine homeostasis
threonine homeostasis
A homeostatic process involved in the maintenance of a steady state level of glutamate within a cell.
cellular glutamate homeostasis
glutamate homeostasis
A homeostatic process involved in the maintenance of a steady state level of orthinine within a cell.
cellular ornithine homeostasis
ornithine homeostasis
A homeostatic process involved in the maintenance of a steady state level of lysine within a cell.
cellular lysine homeostasis
lysine homeostasis
A homeostatic process involved in the maintenance of a steady state level of histidine within a cell.
cellular histidine homeostasis
histidine homeostasis
A homeostatic process involved in the maintenance of a steady state level of arginine within a cell.
arginine homeostasis
cellular arginine homeostasis
Catalysis of the reaction: 9,9',15-tri-cis-zeta-carotene = 9,9'-di-cis-zeta-carotene.
9,15,9\'-tricis-zeta-carotene cis-trans-isomerase
Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine.
cardiolipin synthase
Catalyzes the multi-step reaction: L-tryptophan + 2 O2 + 2 reduced  = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H+ + 3 H2O + 2 oxidized .
L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)
tryptophan N-hydroxylase activity
The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic to Golgi membrane
Catalysis of the reaction: 6-carboxyhexanoyl- methyl ester + H2O = 6-carboxyhexanoyl- + H+ + methanol.
pimelyl- methyl ester hydrolase activity
A developmental process that results in the initiation of an axillary shoot meristem. An axillary shoot meristem is a shoot meristem formed in the axil of a leaf.
axillary bud meristem initiation
The directed movement of L-histidine into the vacuole across the vacuolar membrane.
histidine transmembrane import into vacuole
vacuolar histidine import
The directed movement of L-arginine into the vacuole across the vacuolar membrane.
arginine transmembrane import into vacuole
vacuolar arginine import
The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.
glomerular visceral epithelial cell migration
Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5).
cytochrome-b5 reductase activity
Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5).
cytochrome b5 reductase activity
The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate GDP-alpha-D-mannose.
L-ascorbic acid biosynthesis via GDP-alpha-D-mannose
Smirnoff-Wheeler\'s pathway
The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate UDP-alpha-D-glucuronate.
L-ascorbic acid biosynthesis via UDP-alpha-D-glucuronate
The directed movement of a peptide pheromone across a membrane and out of a cell.
peptide pheromone export by membrane transport
The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as it occurs in certain types of bacteria, mainly Acetobacter, Sarcina ventriculi and Agrobacteria.
bacterial cellulose biosynthesis
A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge.
Midbody ring
Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP.
ATP-dependent phosphatidylcholine transporter activity
ATPase-coupled phosphatidylcholine transporter activity
phosphatidylcholine floppase activity (cytosolic to exoplasmic leaflet)
phosphatidylcholine-translocating ATPase activity
Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
ATP-dependent phosphatidylethanolamine transporter activity
ATPase-coupled phosphatidylethanolamine transporter activity
phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaflet)
phosphatidylethanolamine-translocating ATPase activity
Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP.
ATPase-coupled phosphatidylserine transporter activity
ATPase-dependent phosphatidylserine transporter activity
phosphatidylserine floppase activity (cytosolic to exoplasmic leaflet)
phosphatidylserine-translocating ATPase activity
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase IV.
RNA polymerase IV transcription factor complex
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase V.
RNA polymerase V transcription factor complex
Catalysis of the reaction: acetyl-CoA + L-lysine = CoA + H+ + N(6)-acetyl-L-lysine.
acetyl-CoA:L-lysine N6-acetyltransferase
A process in which microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface.
multicellular pellicle formation
Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3.
cyclic adenosine monophosphate deaminase activity
The process of removing the PCNA complex from DNA when Okazaki fragments are completed or the replication fork terminates.
PCNA unloading
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
activation of ARF GTPase activity
activation of Cdc42 GTPase activity
activation of Rab GTPase activity
activation of Rac GTPase activity
activation of Ral GTPase activity
activation of Ran GTPase activity
activation of Rap GTPase activity
activation of Ras GTPase activity
activation of Rho GTPase activity
ARF GTPase activation
Cdc42 GTPase activation
Rab GTPase activation
Rac GTPase activation
Ral GTPase activation
Ran GTPase activation
Rap GTPase activation
Ras GTPase activation
Rho GTPase activation
Catalysis of the reaction: CTP + Neu5Gc = diphosphate + CMP-Neu5Gc.
CMP-Neu5Gc synthetase activity
Catalysis of the reaction: CTP + KDN = diphosphate + CMP-KDN.
CMP-KDN synthetase activity
cytidine 5\'-monophospho-2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid synthetase activity
The desmosomal part containing the desmosomal cadherins, desmogleins and desmocollins, that establish contact and adhere to neighboring cells in a Ca2+-dependent manner.
desmoglea
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the provision of a combination of complex inanimate and social stimulations in the organism's housing environment.
response to the introduction of novel objects
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose.
cellular response to OGD
The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional.
cerebrospinal fluid flow
CSF circulation
CSF flow
The series of molecular signals generated as a consequence of the peptide neurotransmitter galanin binding to a cell surface receptor.
galanin signaling pathway
galanin signalling pathway
galanin-activated signalling pathway
Any process that results in a change in state or activity of a cell or a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a higher than normal number of multicellular organisms living per unit area.
response to crowding
Prevention of degradation of telomerase RNA (TERC) molecules.
TERC stabilization
A process in which a calcium ion is transported from one side of a membrane to the other by means of a low voltage-gated calcium channel.
generation of T-type calcium current
The dissemination of mature viral particles from a host cell via the destabilization of the cell outer membrane.
disruption by virus of host outer membrane
A G protein-coupled receptor activity that is responsible for the sense of bitter taste.
G protein-coupled receptor bitter taste receptor activity
G-protein coupled receptor bitter taste receptor activity
A G protein-coupled receptor activity that is responsible for the sense of sweet taste.
G-protein coupled receptor sweet taste receptor activity
A non-GPCR transmembrane signaling receptor activity that is responsible for contact chemoreception.
contact chemosensation receptor activity
Enables the transmembrane transfer of a monoatomic cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts.
glycine betaine-activated nonselective monovalent cation channel activity
A eukaryotically conserved heterodimeric protein complex (comprising adherin and the chromatid cohesion factor MAU2/Scc4/Ssl3) required for the loading of a cohesin, complex onto DNA.
Mis4-Ssl3 cohesin loading complex
Catalysis of the reaction: FMN + H2O = phosphate + riboflavin.
FMN phosphatase
The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function.
hetero-receptor complex formation
A region of the cell cortex that contains a higher concentration of growth polarity factors than the surrounding cortex and that changes position over time. An example is found in fission yeast cells during early mating, in which the GTPase Cdc42 dynamically to discrete zones within the cortex prior to shmoo formation.
dynamic polarity patch at the cell cortex
Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom.
toxin receptor binding
A four subunit complex, that comprises all the necessary RNA processing enzymes (endonuclease, polynucleotide kinase, and exonuclease) to mediate 'cistronic rRNA transcript ITS2 (internal transcribed spacer) cleavage' (GO:0000448).
Las1-Grc3-Rat1-Rai1
A extracellular matrix complex involved in cell adhesion and cell migration. Typically homotrimeric or homohexameric. In mammals, four complexes exist: Tenascin-C, Tenascin-N (also known as Tenascin-W), Tenascin-X and Tenascin-R.
Tenascin-C
Tenascin-N
Tenascin-R
Tenascin-W
Tenascin-X
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nematicide stimulus. Nematicides are chemicals used to kill nematodes.
response to antihelmintic
response to nematocide
The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane.
inner bounding mitochondrial membrane
Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.
AKH receptor activity
Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.
AKH binding
Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.
AKH receptor binding
Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone.
4,8,12-trimethyl-1,3,7,11-tridecatetraene synthase activity
TMTT synthase activity
Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone.
(3E)-4,8-dimethylnona-1,3,7-triene synthase activity
DNMT synthase activity
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.
cellular response to GM-CSF stimulus
The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen.
lymphocyte homing
Binding to a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3).
centromere-specific nucleosome binding
centromeric nucleosome binding
The chemical reactions and pathways resulting in the formation of phthiocerol, a lipid-based 1,3-glycol consisting of (3S,4R)-3-methoxy-4-methylnonacosane having (9R)- and (11S)-hydroxy substituents.
phthiocerol anabolism
phthiocerol biosynthesis
phthiocerol formation
phthiocerol synthesis
The chemical reactions and pathways resulting in the formation of phenolic phthiocerol, a phthiocerol derivative having a 4-hydroxyphenyl substituent at the 29-position.
phenolic phthiocerol anabolism
phenolic phthiocerol biosynthesis
phenolic phthiocerol formation
phenolic phthiocerol synthesis
phenolphthiocerol biosynthesis
A chromosomal region that contains fork pausing elements influencing the progression and merging of DNA replication forks.
TER
The directed movement of a protein to a specific location in the endoplasmic reticulum membrane.
establishment of protein localisation in endoplasmic reticulum membrane
establishment of protein localization in endoplasmic reticulum membrane
The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine).
L-kynurenine breakdown
L-kynurenine catabolism
L-kynurenine degradation
The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid.
L-glutamate anabolism
L-glutamate biosynthesis
L-glutamate formation
L-glutamate synthesis
The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase.
agmatine anabolism
agmatine biosynthesis
agmatine formation
agmatine synthesis
A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex.
CLF-CLC complex
A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space.
sCNTFR-CLC complex
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus.
cellular response to T4 stimulus
An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3.
IRF3:IRF3 complex
An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5.
IRF5:IRF5 complex
An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 7.
IRF7:IRF7 complex
An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 7.
IRF3:IRF7 complex
A protein complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunits).
TAK1 kinase complex
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in).
selenite:H+ symporter activity
selenite:hydrogen symporter activity
The directed movement of inorganic selenite (HSeO3-1 at physiological pH) across a plasma membrane.
plasma membrane hydrogenselenite transport
The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.
vascular smooth muscle cell fate specification
The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.
vascular smooth muscle cell fate determination
An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5.
IRF3:IRF5 complex
The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
IL-17F production
The chemical reactions and pathways resulting in the formation of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid.
polyacyltrehalose anabolism
polyacyltrehalose biosynthesis
polyacyltrehalose formation
polyacyltrehalose synthesis
The process in which the frontonasal suture, between frontal and nasal bones, is generated and organized.
nasofrontal suture morphogenesis
The process in which the nasal suture is generated and organized.
internasal suture morphogenesis
The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo.
structural constituent of egg white
The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels.
angiogenic tip cell fate specification
The process involved in the specification of identity of an endothelial stalk cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial stalk cell is a specialized endothelial cell which follows behind the tip cell of an angiogenic sprout.
angiogenic stalk cell fate specification
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment.
endoplasmic reticulum-Golgi intermediate compartment organisation
endoplasmic reticulum-Golgi intermediate compartment organization and biogenesis
ER-Golgi intermediate compartment organization
ERGIC organization
The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane.
GABA receptor clustering
The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane.
N-methyl-D-aspartate receptor clustering
NMDA receptor clustering
The receptor clustering process involved in assembly of the presynaptic membrane in which neurexins are localized to distinct domains in the cell membrane. Neurexins are synaptic cell surface proteins which act as cell recognition molecules at nerve terminals.
neurexin clustering
Nrxn clustering
presynaptic neurexin clustering
The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses.
Geph clustering
The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons.
GKAP clustering
The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons.
neuroligin clustering
Nlgn clustering
postsynaptic neuroligin clustering
Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
positive regulation of inhibitory post-synaptic membrane potential
positive regulation of IPSP
Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA).
pre-messenger RNA intronic pyrimidine-rich binding
Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings.
PCB binding
polychlorobiphenyl binding
Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours.
regulation of mRNA translation in response to circadian clock