NothingMuch/GO-Terms huggingface dataset:
The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.
ER translocation
SRP-dependent cotranslational membrane targeting, translocation
SRP-dependent cotranslational protein-membrane targeting, translocation
translocation during SRP-dependent cotranslational protein targeting to membrane
The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting.
signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational membrane targeting, signal sequence recognition
SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition
The removal of the signal peptide from a nascent protein during cotranslational membrane targeting.
signal sequence processing during SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational membrane targeting, signal sequence processing
SRP-dependent cotranslational protein-membrane targeting, signal sequence processing
The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.
maintenance of protein location in ER lumen
Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes.
vacuolar protein maturation
vacuolar proteolysis
The process of directing proteins towards the peroxisome, usually using signals contained within the protein.
protein-peroxisome targeting
The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.
monoacylglycerol anabolism
monoacylglycerol biosynthesis
monoacylglycerol formation
monoacylglycerol synthesis
monoglyceride biosynthesis
monoglyceride biosynthetic process
The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism.
triacylglycerol mobilization
The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group.
phosphatidyl-N-monomethylethanolamine anabolism
phosphatidyl-N-monomethylethanolamine biosynthesis
phosphatidyl-N-monomethylethanolamine formation
phosphatidyl-N-monomethylethanolamine synthesis
PMME biosynthesis
PMME biosynthetic process
The chemical reactions and pathways involving any 1,2-diacyl-sn-glycero-3-phosphocholine, the compounds most commonly designated lecithin.
1,2-diacyl-sn-glycero-3-phosphocholine metabolism
lecithin metabolic process
The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine.
Kennedy pathway
phosphatidylcholine biosynthesis from choline
The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
phosphatidylserine breakdown
phosphatidylserine catabolism
phosphatidylserine degradation
The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli.
PAF biosynthesis
PAF biosynthetic process
platelet activating factor anabolism
platelet activating factor biosynthesis
platelet activating factor formation
platelet activating factor synthesis
The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine.
3-keto-dihydrosphingosine metabolic process
3-keto-dihydrosphingosine metabolism
3-keto-sphinganine metabolism
The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol.
dihydrosphingosine-1-phosphate biosynthesis
dihydrosphingosine-1-phosphate biosynthetic process
sphinganine-1-phosphate anabolism
sphinganine-1-phosphate biosynthesis
sphinganine-1-phosphate formation
sphinganine-1-phosphate synthesis
The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains two phosphoryl (-P(O)=) groups and a mannose derivative.
M(IP)2C metabolic process
M(IP)2C metabolism
mannosyl diphosphorylinositol ceramide metabolism
The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.
galactosylceramide anabolism
galactosylceramide biosynthesis
galactosylceramide formation
galactosylceramide synthesis
The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.
galactosylceramide breakdown
galactosylceramide catabolism
galactosylceramide degradation
The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
sphingomyelin anabolism
sphingomyelin biosynthesis
sphingomyelin formation
sphingomyelin synthesis
The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues.
ganglioside breakdown
ganglioside catabolism
ganglioside degradation
The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects.
ecdysone anabolism
ecdysone biosynthesis
ecdysone formation
ecdysone synthesis
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
cholesterol breakdown
cholesterol catabolism
cholesterol degradation
The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects.
ecdysone breakdown
ecdysone catabolism
ecdysone degradation
The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.
progesterone breakdown
progesterone catabolism
progesterone degradation
The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
androgen breakdown
androgen catabolism
androgen degradation
The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
estrogen breakdown
estrogen catabolism
estrogen degradation
oestrogen catabolic process
oestrogen catabolism
The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol.
farnesol anabolism
farnesol biosynthesis
farnesol formation
farnesol synthesis
The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss.
cuticle hydrocarbon anabolism
cuticle hydrocarbon biosynthesis
cuticle hydrocarbon formation
cuticle hydrocarbon synthesis
The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.
ommochrome anabolism
ommochrome biosynthesis
ommochrome formation
ommochrome synthesis
The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group.
pteridine anabolism
pteridine biosynthesis
pteridine formation
pteridine synthesis
pterin biosynthesis
pterin biosynthetic process
The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.
5,6,7,8-tetrahydrobiopterin biosynthetic process
tetrahydrobiopterin anabolism
tetrahydrobiopterin biosynthesis
tetrahydrobiopterin formation
tetrahydrobiopterin synthesis
The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide.
N-ribosylnicotinamide catabolic process
nicotinamide riboside breakdown
nicotinamide riboside catabolism
nicotinamide riboside degradation
The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH.
NADP (oxidized) biosynthesis
NADP (oxidized) biosynthetic process
NADP (reduced) biosynthesis
NADP (reduced) biosynthetic process
NADP anabolism
NADP biosynthesis
NADP formation
NADP synthesis
NADPH biosynthesis
NADPH biosynthetic process
nicotinamide adenine dinucleotide phosphate biosynthesis
nicotinamide adenine dinucleotide phosphate biosynthetic process
oxidized NADP biosynthesis
oxidized NADP biosynthetic process
oxidized nicotinamide adenine dinucleotide phosphate biosynthesis
oxidized nicotinamide adenine dinucleotide phosphate biosynthetic process
reduced NADP biosynthesis
reduced NADP biosynthetic process
reduced nicotinamide adenine dinucleotide phosphate biosynthesis
reduced nicotinamide adenine dinucleotide phosphate biosynthetic process
The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.
NADP (oxidized) catabolic process
NADP (oxidized) catabolism
NADP (reduced) catabolic process
NADP (reduced) catabolism
NADP breakdown
NADP catabolism
NADP degradation
NADPH catabolic process
NADPH catabolism
nicotinamide adenine dinucleotide phosphate catabolic process
nicotinamide adenine dinucleotide phosphate catabolism
oxidized NADP catabolic process
oxidized NADP catabolism
oxidized nicotinamide adenine dinucleotide phosphate catabolic process
oxidized nicotinamide adenine dinucleotide phosphate catabolism
reduced NADP catabolic process
reduced NADP catabolism
reduced nicotinamide adenine dinucleotide phosphate catabolic process
reduced nicotinamide adenine dinucleotide phosphate catabolism
The chemical reactions and pathways involving the reduced form of flavin adenine dinucleotide.
FADH2 metabolism
reduced flavin adenine dinucleotide metabolic process
The chemical reactions and pathways resulting in the formation of FAD, the oxidized form of flavin-adenine dinucleotide.
FAD anabolism
FAD biosynthesis
FAD formation
FAD synthesis
oxidized flavin adenine dinucleotide biosynthesis
oxidized flavin adenine dinucleotide biosynthetic process
oxidized flavin-adenine dinucleotide biosynthesis
oxidized flavin-adenine dinucleotide biosynthetic process
The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group.
lipoamide metabolism
The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
glutathione breakdown
glutathione catabolism
glutathione degradation
The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate.
7,8-dihydrofolate biosynthesis
7,8-dihydrofolate biosynthetic process
dihydrofolate anabolism
dihydrofolate biosynthesis
dihydrofolate formation
dihydrofolate synthesis
The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX.
biosynthesis of protoporphyrin IX via succinyl CoA
biosynthesis of protoporphyrin IX via succinyl-CoA
biosynthetic process of protoporphyrin IX via succinyl CoA
biosynthetic process of protoporphyrin IX via succinyl-CoA
succinyl CoA pathway
The chemical reactions and pathways resulting in the formation of heme A, a derivative of heme found in cytochrome aa3.
haem A biosynthesis
haem A biosynthetic process
heme A anabolism
heme A biosynthesis
heme A formation
heme A synthesis
The chemical reactions and pathways resulting in the formation of heme B, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes.
haem B biosynthesis
haem B biosynthetic process
heme B anabolism
heme B biosynthesis
heme B formation
heme B synthesis
protoheme biosynthesis
protoheme biosynthetic process
The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f.
haem C biosynthesis
haem C biosynthetic process
heme C anabolism
heme C biosynthesis
heme C formation
heme C synthesis
The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme.
haem oxidation
The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid.
polyphosphate breakdown
polyphosphate catabolism
polyphosphate degradation
The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid.
polyphosphate anabolism
polyphosphate biosynthesis
polyphosphate formation
polyphosphate synthesis
The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cobalt transport
The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into or out of a mitochondrial matrix.
mitochondrial citrate transport
The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial pyruvate transport
pyruvate membrane transport in mitochondria
pyruvate membrane transport in mitochondrion
pyruvate transmembrane transport in mitochondria
pyruvate transmembrane transport in mitochondrion
The process in which a xenobiotic, a compound foreign to the organism exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
drug membrane transport
drug transmembrane transport
multidrug transport
A homeostatic process involved in the maintenance of a steady state level of cobalt (Co2+) ions within a cell.
cellular cobalt ion homeostasis
cobalt homeostasis
The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system.
intracellular iron ion retention
intracellular iron ion sequestering
intracellular iron ion sequestration
intracellular iron ion storage
intracellular retention of iron ion
intracellular sequestration of iron ion
intracellular storage of iron ion
The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system.
extracellular iron ion retention
extracellular iron ion sequestering
extracellular iron ion sequestration
extracellular iron ion storage
extracellular retention of iron ion
extracellular sequestration of iron ion
extracellular storage of iron ion
The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
substrate-bound cell migration, cell extension
The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves.
substrate-bound cell migration, cell contraction
Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.
activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
anti-Gram-negative bacterial peptide induction
anti-Gram-negative bacterial polypeptide induction
stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
up regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
up-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
upregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.
activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
anti-Gram-positive bacterial peptide induction
anti-Gram-positive bacterial polypeptide induction
stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
up regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
up-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
upregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis.
activation of antifungal peptide biosynthetic process
antifungal peptide induction
antifungal polypeptide induction
stimulation of antifungal peptide biosynthetic process
up regulation of antifungal peptide biosynthetic process
up-regulation of antifungal peptide biosynthetic process
upregulation of antifungal peptide biosynthetic process
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
positive regulation of cell cycle arrest by p53-mediated DNA damage response
The modification of actin by addition of ubiquitin groups.
indirect flight muscle actin ubiquitination
The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer.
tubulin assembly
tubulin folding
tubulin-specific chaperone activity
Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme.
axonemal microtubule stabilization
negative regulation of microtubule depolymerization in axoneme
The directed movement of proteins imported into a cell by endocytosis to the vacuole.
delivery of endocytosed proteins to the vacuole
Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.
lysosome pH reduction
The formation of the spindle during meiosis I of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster.
male meiosis I spindle assembly
The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster.
male meiosis II spindle assembly
The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.
female meiosis I spindle assembly
The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.
female meiosis II spindle assembly
The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis.
chromosome migration to spindle pole during mitosis
chromosome movement towards spindle pole during mitosis
mitotic chromosome movement
mitotic chromosome movement to spindle pole
mitotic sister chromosome movement towards spindle pole
sister chromosome movement towards spindle pole during mitosis
A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.
down regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
down regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint
down-regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
down-regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint
G2 DNA damage checkpoint
G2/M transition DNA damage checkpoint
inhibition of signal transduction involved in mitotic G2 DNA damage checkpoint
mitotic cell cycle G2/M transition DNA damage checkpoint
mitotic G2 DNA damage checkpoint
negative regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
negative regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint
positive regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
positive regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint
regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint
signal transduction involved in G2 DNA damage checkpoint
signal transduction involved in G2/M transition DNA damage checkpoint
signal transduction involved in mitotic G2 DNA damage checkpoint
signal transduction involved in mitotic G2/M transition DNA damage checkpoint
A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells.
cytokinesis after meiosis I
A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells.
cytokinesis after meiosis II
A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.
cytokinesis after male meiosis
cytokinesis involved in male meiotic cell cycle