NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction:guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine.
tRNA (guanine(26)-N(2))-dimethyltransferase activity
tRNA (guanosine(26)-N(2))-dimethyltransferase activity
tRNA (m(2)2G26)dimethyltransferase
Catalysis of the reaction: adenosine(22) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine.
tRNA (adenine(22)-N(1))-methyltransferase activity
tRNA (adenosine(22)-N(1))-methyltransferase activity
Catalysis of the reaction: adenosine(9) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine.
tRNA (adenine(9)-N(1))-methyltransferase activity
tRNA m(1)A(9)-methyltransferase
tRNA(m(1)G(9)/m(1)A(9))-methyltransferase
Catalysis of the reaction: adenosine(58) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine.
tRNA (adenine(58)-N(1))-methyltransferase activity
tRNA (m(1)A(58)) methyltransferase
tRNA m(1)A(58) methyltransferase
Any developmental process whose specific outcome is the progression of a gross anatomical part of an animal from an initial immature state, to a later, more mature state.
animal development
Any developmental process whose specific outcome is the progression of a gross anatomical part of a plant from an initial immature state, to a later, more mature state.
plant development
Catalysis of the reaction: guanosine(6) in tRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine.
m(2)G6 methyltransferase
methyltransferase Trm14
A gated channel activity that enables the transmembrane transfer of a sodium ion by a channel that opens in response to a change in pH.
pH-dependent sodium channel activity
pH-sensitive sodium channel activity
A gated channel activity that enables the transmembrane transfer of a calcium ion by a channel that opens in response to a change in pH.
pH-dependent calcium channel activity
pH-sensitive calcium channel activity
The controlled self-propelled movement of a sperm cell from the uterus through the uterotubal junction (UTJ) into the oviduct, where interaction between the sperm and the UTJ acts as a major selective barrier for sperm, allowing only living, motile, uncapacitated, morphologically normal sperm with intact acrosomes to pass from the uterus into the oviduct.
sperm migration from the uterus to the oviduct
sperm migration through the UTJ
Enables the energy-independent facilitated diffusion of bicarbonate through a transmembrane aqueous pore or channel.
hydrogencarbonate channel activity
Catalysis of the reaction: uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA.
PSUI activity
tRNA pseudouridylate synthase
A multi-enzyme complex that catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: branched-chain alpha-ketoacid dehydrogenase (E1, a heterotetramer of two alpha and two beta subunits), dihydrolipoyl transacylase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.
BCKD complex
BKDH complex
The process of regulating the proliferation and elimination of CD8-positive alpha-beta T cells such that the total number of CD8-positive alpha-beta T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
CD8+ T cell homeostasis
CD8-positive T cell homeostasis
A multi-enzyme complex that catalyzes the oxidative decarboxylation of 2-oxoadipate to glutaryl-CoA, thereby acting in the final step of lysine and tryptophan catabolism in mitochondria. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: 2-oxoadipate dehydrogenase (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3).
OADHC
Catalysis of the reaction: a quinol + nitrate = a quinone + H2O + nitrite.
dissimilatory nitrate reductase
dissimilatory nitrate reductase activity
nitrate reductase A activity
nitrate reductase Z activity
quinol-nitrate oxidoreductase activity
Enables size- and charge-selective transport of solutes through a tight junction barrier paracellularly, across the epithelium.
claudin pore
An organelle membrane contact site between peroxisomal membrane and mitochondrial outer membrane.
PerMit contact
PerMit contact site
Catalysis of the reaction: a C28-steroid + O2 + reduced NADPH--hemoprotein reductase = a (22S)-22-hydroxy C28-steroid + H+ + H2O + oxidized NADPH--hemoprotein reductase. Also catalyzes the C-22 hydroxylation of a variety of C27 and C29 steroids.
steroid C-22 hydroxylase activity
A process of exocytosis that uses the autophagy machinery to facilitate secretion of the cytosolic cargo such as leaderless cytosolic proteins which cannot enter the conventional secretory pathway operating via the endoplasmic reticulum and the Golgi apparatus.
autophagy-dependent secretion
secretory autophagy
Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C/protein kinase C signal transduction.
negative regulation of PLC/PKC signal transduction
A protein folding process that facilitates the import of a subset of soluble proteins into mitochondrial intermembrane space via disulfide bond formation.
MIA pathway
mitochondrial intermembrane space assembly pathway
The binding activity of a molecule that brings together two mitochondrion membranes via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.
mitochondrion membrane tether activity
mitochondrion outer membrane tether activity
Catalysis of the reaction: -L-cysteine + glycine + NAD(+) = -dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide.
ADP-thiazole synthase activity
suicide thiamine thiazole synthase activity
Catalysis of the reaction: cytidine(32)/uridine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methyluridine(32) in tRNA + H+ + S-adenosyl-L-homocysteine.
TrMet(Xm32) activity
A Golgi-derived organelle that forms in primary spermatocytes during spermatogenesis of some nematodes including C. elegans. This 'double organelle' consists of a fibrous body containing major sperm protein and a membranous organelle that envelops the developing fibrous body.
FB-MO
A sodium-specific negative tropism that is crucial for surviving and thriving under high salinity.
root halotropism
A highly conserved protein complex that recognises and elicits the rapid degradation of mRNAs in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
Upf complex
A complex composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1, that functions in the stability and shape of the erythrocyte membrane in human.
ankyrin complex
erythrocyte ankyrin-1 complex
An outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis. In humans, it contains the subunits SKA1, SKA2 and SKA3.
SKA1 complex
Enables the transfer of isopentenyl pyrophosphate from one side of a membrane to the other.
IPP transmembrane transport activity
isopentenyl diphosphate transmembrane transport activity
A protein coat that surrounds nucleic acid to form a structure similar to a virus capsid. Virus-like capsids are non-infectious and are encoded by endogenous (non-viral) genes. Fly and tetrapod Arc (ancestrally-related to retrotransposon Gag) are examples of proteins that can self-assemble into capsid-like structures which encapsulate Arc mRNA and mediate the intercellular transmission of RNA.
virus-like particle
The directed import of D-alanine from the extracellular region across the plasma membrane and into the cytosol.
D-alanine import
D-alanine import into cell
D-alanine uptake
Catalysis of the reaction: cholesterol + H+ + NAD(P)H + O2 = 7-dehydrocholesterol + 2 H2O + NAD(P)+.
C-7 cholesterol dehydrogenase
cholesterol 7,8-dehydrogenase
Catalysis of the joining of an RNA with 3'-phosphate or 2',3'-cyclic-phosphate ends to an RNA with 5'-hydroxy ends according to either (i) a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP; or (ii) a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H+.
3\'-phosphate/5\'-hydroxy nucleic acid ligase activity
Binding to a cyclic di-AMP nucleotide.
cyclic dimeric adenosine monophosphate binding
The elimination of zinc ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine.
renal zinc ion excretion
renal zinc secretion
Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-tyrosine (consensus YSPTSPS)(position 1) + H2O = RNA polymerase II large subunit + phosphate.
RNA polymerase II C-terminal domain Y1 phosphatase activity
Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-threonine (consensus YSPTSPS)(position 4) + H2O = RNA polymerase II large subunit + phosphate.
RNA polymerase II C-terminal domain T4 phosphatase activity
Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 2) + H2O = RNA polymerase II large subunit + phosphate.
RNA polymerase II C-terminal domain S2 phosphatase activity
Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 5) + H2O = RNA polymerase II large subunit + phosphate.
RNA polymerase II C-terminal domain S5 phosphatase activity
Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 7) + H2O = RNA polymerase II large subunit + phosphate.
RNA polymerase II C-terminal domain S7 phosphatase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: basic L-amino acid(in) + neutral L-amino acid(out) = basic L-amino acid(in) + neutral L-amino acid(out).
neutral L-amino acid:cationic L-amino acid antiporter activity
neutral L-amino acid:dibasic L-amino acid antiporter activity
neutral L-amino acid:positively-charged polar L-amino acid antiporter activity
system b(0,+)-type activity
Any process involved in transcription termination-coupled 3' processing of RNA polymerase II mRNA transcripts by the 3' end cleavage and addition of a poly(A) tail.
cotranscriptional 3\' processing of RNA polymerase II mRNA transcripts
mRNA polyadenylation
The binding activity of a protein that brings together another protein and a tRNA, permitting those molecules to function in a coordinated way.
tRNA carrier
The activity of bending or deforming a membrane. This activity can occur by multiple mechanisms including the insertion amphipathic domains into one or both leaflets.
membrane curving
A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (Human TRIP4).
RQT complex
A protein quality control pathway that removes ubiquitinated proteins from the nuclear inner membrane before transferring them to the proteasome for degradation.
INMAD pathway
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 5) + H2O = histone H4 L-lysine (position 5) + acetate. This reaction represents the removal of an acetyl group from lysine at position 5 of the histone H4 protein.
histone H4K5 deacetylase activity
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 8) + H2O = histone H4 L-lysine (position 8) + acetate. This reaction represents the removal of an acetyl group from lysine at position 8 of the histone H4 protein.
histone H4K48 deacetylase activity
Any process involved in transcription termination-coupled 3' processing of RNA polymerase II lncRNA transcripts by the 3' end cleavage and addition of a poly(A) tail.
lncRNA 3\' end processing
lncRNA 3\'-end processing
A protein complex consisting of cyclin L and cyclin-dependent kinase 11 (CDK11). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
Cdk11-Cyclin L complex
Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->4)-D-mannosyl-D-mannose linkage.
glycosylphosphatidylinositol-mannosyltransferase I
GPI-MT-I activity
The chemical reactions and pathways resulting in the formation of dolichol phosphate mannose.
Dol-P-Man biosynthesis
dolichol phosphate mannose biosynthesis
dolichol-P-mannose biosynthesis
The chemical reactions and pathways resulting in the formation of phosphatidylinositol 4-phosphate.
1-phosphatidyl-1D-myo-inositol 4-phosphate biosynthesis
1-phosphatidyl-1D-myo-inositol biosynthetic process
phosphatidylinositol (PI)-4- phosphate biosynthetic process
phosphatidylinositol-4-phosphate synthesis
PI4P biosynthesis
Any process that stops, prevents or reduces the frequency, rate or extent of anthocyanin catabolic process.
down regulation of anthocyanin breakdown
down regulation of anthocyanin catabolic process
down regulation of anthocyanin catabolism
down regulation of anthocyanin degradation
negative regulation of anthocyanin breakdown
negative regulation of anthocyanin catabolism
negative regulation of anthocyanin degradation
Any process that activates or increases the frequency, rate or extent of anthocyanin catabolic process.
positive regulation of anthocyanin breakdown
positive regulation of anthocyanin catabolism
positive regulation of anthocyanin degradation
up regulation of anthocyanin breakdown
up regulation of anthocyanin catabolic process
up regulation of anthocyanin catabolism
up regulation of anthocyanin degradation
Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.
down regulation of blood coagulation factor activity
down regulation of serine-type endopeptidase activity
negative regulation of blood coagulation factor activity
Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity.
positive regulation of blood coagulation factor activity
up regulation of blood coagulation factor activity
up regulation of serine-type endopeptidase activity
Any process that activates or increases the frequency, rate or extent of dendrite development.
up regulation of dendrite development
Any process that stops, prevents or reduces the frequency, rate or extent of corticotropin-releasing hormone receptor activity.
down regulation of adrenocorticotropin-releasing hormone receptor activity
down regulation of corticotropin-releasing factor receptor activity
down regulation of corticotropin-releasing hormone receptor activity
down regulation of CRF receptor activity
down regulation of CRH receptor activity
negative regulation of adrenocorticotropin-releasing hormone receptor activity
negative regulation of corticotropin-releasing factor receptor activity
negative regulation of CRF receptor activity
negative regulation of CRH receptor activity
Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
down regulation of cytokine production involved in acute inflammatory response
down regulation of cytokine production involved in inflammatory response
negative regulation of cytokine production involved in acute inflammatory response
Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
positive regulation of cytokine production involved in acute inflammatory response
up regulation of cytokine production involved in acute inflammatory response
up regulation of cytokine production involved in inflammatory response
Any process that activates or increases the frequency, rate or extent of protein kinase C activity.
positive regulation of PKC
positive regulation of PKC activity
up regulation of PKC
up regulation of PKC activity
Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.
down regulation of cell spreading during cell substrate adhesion
down regulation of substrate adhesion dependent cell spreading
down regulation of substrate adhesion-dependent cell spreading
negative regulation of cell spreading during cell substrate adhesion
negative regulation of substrate adhesion dependent cell spreading
Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.
positive regulation of cell spreading during cell substrate adhesion
positive regulation of substrate adhesion dependent cell spreading
up regulation of cell spreading during cell substrate adhesion
up regulation of substrate adhesion dependent cell spreading
up regulation of substrate adhesion-dependent cell spreading
Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.
down regulation of membrane ruffle formation
down regulation of membrane ruffling
down regulation of ruffle assembly
negative regulation of membrane ruffle formation
negative regulation of membrane ruffling
Any process that activates or increases the frequency, rate or extent of ruffle assembly.
positive regulation of membrane ruffle formation
positive regulation of membrane ruffling
up regulation of membrane ruffle formation
up regulation of membrane ruffling
up regulation of ruffle assembly
Any process that modulates the frequency, rate or extent of pectin biosynthetic process.
regulation of pectin anabolism
regulation of pectin biosynthesis
regulation of pectin formation
regulation of pectin synthesis
Any process that stops, prevents or reduces the frequency, rate or extent of trichome patterning.
down regulation of trichome distribution
down regulation of trichome pattern biosynthesis
down regulation of trichome pattern formation
down regulation of trichome pattern specification
down regulation of trichome patterning
down regulation of trichome spacing
down-regulation of trichome distribution
down-regulation of trichome pattern biosynthesis
down-regulation of trichome pattern formation
down-regulation of trichome pattern specification
down-regulation of trichome patterning
down-regulation of trichome spacing
downregulation of trichome distribution
downregulation of trichome pattern biosynthesis
downregulation of trichome pattern formation
downregulation of trichome pattern specification
downregulation of trichome patterning
downregulation of trichome spacing
inhibition of trichome distribution
inhibition of trichome pattern biosynthesis
inhibition of trichome pattern formation
inhibition of trichome pattern specification
inhibition of trichome patterning
inhibition of trichome spacing
negative regulation of trichome distribution
negative regulation of trichome pattern biosynthesis
negative regulation of trichome pattern formation
negative regulation of trichome pattern specification
negative regulation of trichome spacing
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to heat.
down regulation of cellular response to heat
down regulation of cellular response to heat stress
down-regulation of cellular response to heat
down-regulation of cellular response to heat stress
downregulation of cellular response to heat
downregulation of cellular response to heat stress
inhibition of cellular response to heat
inhibition of cellular response to heat stress
negative regulation of cellular response to heat stress
Any process that activates or increases the frequency, rate or extent of cellular response to heat.
activation of cellular response to heat
activation of cellular response to heat stress
positive regulation of cellular response to heat stress
up regulation of cellular response to heat
up regulation of cellular response to heat stress
up-regulation of cellular response to heat
up-regulation of cellular response to heat stress
upregulation of cellular response to heat
upregulation of cellular response to heat stress
Any process that activates or increases the frequency, rate or extent of cellular response to hypoxia.
activation of cellular response to hypoxia
activation of cellular response to hypoxic stress
activation of cellular response to lowered oxygen tension
positive regulation of cellular response to hypoxic stress
positive regulation of cellular response to lowered oxygen tension
up regulation of cellular response to hypoxia
up regulation of cellular response to hypoxic stress
up regulation of cellular response to lowered oxygen tension
up-regulation of cellular response to hypoxia
up-regulation of cellular response to hypoxic stress
up-regulation of cellular response to lowered oxygen tension
upregulation of cellular response to hypoxia
upregulation of cellular response to hypoxic stress
upregulation of cellular response to lowered oxygen tension
Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination.
down regulation of protein K63-linked polyubiquitination
down regulation of protein K63-linked ubiquitination
down-regulation of protein K63-linked polyubiquitination
down-regulation of protein K63-linked ubiquitination
downregulation of protein K63-linked polyubiquitination
downregulation of protein K63-linked ubiquitination
inhibition of protein K63-linked polyubiquitination
inhibition of protein K63-linked ubiquitination
negative regulation of protein K63-linked polyubiquitination
Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process.
down regulation of retinoic acid anabolic process
down regulation of retinoic acid biosynthetic process
down-regulation of retinoic acid anabolic process
down-regulation of retinoic acid biosynthetic process
downregulation of retinoic acid anabolic process
downregulation of retinoic acid biosynthetic process
inhibition of retinoic acid anabolic process
inhibition of retinoic acid biosynthetic process
negative regulation of retinoic acid anabolic process
Any process that activates or increases the frequency, rate or extent of retinoic acid biosynthetic process.
activation of retinoic acid anabolic process
activation of retinoic acid biosynthetic process
positive regulation of retinoic acid anabolic process
up regulation of retinoic acid anabolic process
up regulation of retinoic acid biosynthetic process
up-regulation of retinoic acid anabolic process
up-regulation of retinoic acid biosynthetic process
upregulation of retinoic acid anabolic process
upregulation of retinoic acid biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of leaf senescence.
down regulation of leaf senescence
down-regulation of leaf senescence
downregulation of leaf senescence
inhibition of leaf senescence
Any process that activates or increases the frequency, rate or extent of leaf senescence.
activation of leaf senescence
up regulation of leaf senescence
up-regulation of leaf senescence
upregulation of leaf senescence