NothingMuch/GO-Terms huggingface dataset:
A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.
CAAX-box protein processing
farnesylated protein maturation
The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles.
20S proteasome assembly
Catalysis of the hydroxylation of the C-2 position in a fatty acid. The 2-hydroxylation may occur on free fatty acids or within the fatty acyl chain of a sphingolipid.
fatty acid alpha-hydroxylase activity
A homeostatic process involved in the maintenance of a steady state level of amino acids within a cell.
amino acid homeostasis
cellular amino acid homeostasis
Any process that modulates the frequency, rate or extent of reductive pentose-phosphate cycle.
regulation of C3 photosynthesis
regulation of Calvin cycle
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole.
lytic vacuolar assembly
lytic vacuole biogenesis
lytic vacuole organisation
lytic vacuole organization and biogenesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in phragmoplast, a plant cell specific structure that forms during late cytokinesis. Phragmoplast serves as a scaffold for cell plate assembly and subsequent formation of a new cell wall separating the two daughter cells.
phragmoplast microtubule cytoskeleton organization
phragmoplast microtubule organisation
A small RNA-based gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism.
gene silencing by RNA-directed DNA methylation
RdDM
RNA-directed DNA methylation
A process in which a symbiont alters or subverts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
modulation by symbiont of host NF-kappaB-mediated signal transduction pathway
perturbation of host canonical NF-kappaB cascade
perturbation of host I-kappaB kinase/NF-kappaB cascade
symbiont-mediated perturbation of host canonical NF-kappaB cascade
An action potential that occurs in a sinoatrial node cardiac muscle cell.
SA node cardiac muscle cell action potential
SAN cardiac muscle cell action potential
sinoatrial node cardiac muscle cell action potential
sinus node cardiac muscle cell action potential
An action potential that occurs in an atrioventricular node cardiac muscle cell.
atrioventricular node cardiac muscle cell action potential
AV node cardiac muscle cell action potential
Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte.
SA node cardiac muscle cell to atrial cardiac muscle cell signalling
SA node cardiomyocyte to atrial cardiomyocyte signalling
SAN cardiomyocyte to atrial cardiomyocyte signalling
sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling
sinus node cardiomyocyte to atrial cardiomyocyte signalling
Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium.
cell-cell signalling involved in cardiac conduction
The series of molecular signals beginning with a G protein-coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, to activate adenylate cyclase, which contributes to a circulatory system process carried out by the heart.
adrenergic receptor signaling pathway involved in heart process
adrenergic receptor signalling pathway involved in heart process
beta-adrenergic receptor signalling pathway involved in heart process
Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell.
atrial cardiomyocyte to atrioventricular node cell signaling
atrial cardiomyocyte to AV node cell signaling
atrial cardiomyocyte to AV node cell signalling
Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte.
atrioventricular node to bundle of His cell signaling
AV node cell to bundle of His cell signalling
Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte.
bundle of His cardiac muscle cell to Purkinje myocyte signaling
bundle of His cardiac muscle cell to Purkinje myocyte signalling
Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell.
Purkinje myocyte to ventricular cardiac muscle cell signalling
The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules.
cardiomyocyte-cardiomyocyte adhesion
An action potential that occurs in a bundle of His cell.
bundle of His cardiac muscle cell action potential
The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
membrane depolarization during atrioventricular node cardiac muscle cell action potential
membrane depolarization during AV node cardiac muscle cell action potential
The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
atrial cardiomyocyte to atrioventricular node cell communication
atrial cardiomyocyte to AV node cell communication
The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
atrioventricular node cell to bundle of His cell communication
The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
atrioventricular junction myocyte to bundle branch myocyte
bundle branch myocyte to Purkinje myocyte communication
bundle of His cardiac muscle cell to Purkinje myocyte communication
bundle of His myocyte to atrioventricular junction myocyte
ventricular conduction system cell to cell communication
The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
SA node cardiac muscle cell to atrial cardiac muscle cell communication
SA node cardiomyocyte to atrial cardiomyocyte communication
SAN cardiomyocyte to atrial cardiomyocyte communication
sinoatrial node cardiomyocyte to atrial cardiomyocyte communication
sinus node cardiomyocyte to atrial cardiomyocyte communication
A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart.
G-protein coupled acetylcholine receptor signaling pathway involved in heart process
G-protein coupled acetylcholine receptor signalling pathway involved in heart process
M2 receptor signaling pathway involved in heart process
muscarinic receptor signaling pathway involved in heart process
A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by angiotensin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
angiotensin-mediated signaling pathway via activation of phospholipase C
Gq-coupled angiotensin receptor signaling pathway
phospholipase C-activating angiotensin receptor signaling pathway
phospholipase C-activating angiotensin-mediated signaling pathway
PLC-activating angiotensin receptor signaling pathway
An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.
angiotensin receptor signaling pathway involved in heart process
angiotensin receptor signalling pathway involved in heart process
angiotensin-mediated signaling pathway involved in heart process
A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
endothelin signaling pathway
An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart.
G-protein coupled receptor signaling pathway involved in heart process
G-protein coupled receptor signalling pathway involved in heart process
GPCR signaling pathway involved in cardiac process
GPCR signaling pathway involved in heart process
The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol.
amino acid import into cell
amino acid transmembrane import
L-amino acid import
L-amino acid uptake
Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
regulation of protein kinase C signaling cascade
regulation of protein kinase C signalling cascade
Any process that modulates the frequency, rate or extent of heterochromatin formation at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin.
regulation of chromatin silencing at centromere
regulation of pericentric heterochromatin assembly
Any process that modulates the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette.
regulation of chromatin silencing at silent mating-type cassette
regulation of silent mating-type cassette heterochromatin assembly
Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.
regulation of transmembrane receptor protein serine/threonine kinase signalling pathway
Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.
positive regulation of transmembrane receptor protein serine/threonine kinase signalling pathway
Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.
negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin.
pancreatic E cell differentiation
The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi.
cargo loading into COPII vesicle
cargo loading into COPII-coated vesicle
cargo selection into COPII-coated vesicle
COPII coat-cargo complex assembly
The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle.
COPII vesicle budding
ER exit
ER vesicle budding
A receptor-mediated endocytosis process involved in intracellular cholesterol transport.
receptor-mediated endocytosis involved in intracellular cholesterol transport
receptor-mediated endocytosis of LDL
receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
regulation of mitochondrial division
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleoid. The nucleoid is the region of a bacterial cell, virion, mitochondrion or chloroplast to which the DNA is confined.
nucleoid organisation
A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes.
membrane scission
The directed movement of a protein to a specific location in a membrane.
establishment of protein localisation in membrane
establishment of protein localization in membrane
The directed movement of a protein to a specific location in the mitochondrial membrane.
establishment of protein localisation in mitochondrial membrane
establishment of protein localization in mitochondrial membrane
Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane.
endoplasmic reticulum membrane organisation
The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance.
Golgi apparatus reassembly
Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
regulation of spindle formation
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity.
microtubule cytoskeleton organisation involved in establishment of planar polarity
Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.
regulation of nephrogenesis
Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.
positive regulation of nephrogenesis
Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.
negative regulation of nephrogenesis
Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.
regulation of establishment of BBB
The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis.
chromosome localisation to nuclear envelope involved in homologous chromosome segregation
Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle.
regulation of spindle organisation
Any process that modulates the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light.
regulation of phytochrome signaling pathway
regulation of red or far-red light signalling pathway
Any process that modulates the rate, frequency, or extent of centromere complex assembly, the aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex.
centromere licensing
Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
spindle checkpoint activation
Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
spindle checkpoint silencing
Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
regulation of chromosome-kinetochore attachment
regulation of NMS complex assembly
Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle.
regulation of chromosome congression
Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.
regulation of arachidonic acid secretion
Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation.
cell motility involved in somitogenic axis elongation
Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
regulation of transmembrane calcium influx
Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
positive regulation of transmembrane calcium influx
Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
negative regulation of transmembrane calcium influx
A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.
regulation of transcription by nitrogen catabolites
A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.
positive regulation of transcription by nitrogen catabolites
A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.
negative regulation of transcription by nitrogen catabolites
nitrogen catabolite repression
Any process that modulates the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion.
regulation of mitochondrial DNA synthesis
The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis.
spindle assembly involved in meiosis
Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.
spindle assembly involved in mitosis
Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic  acid.
regulation of protein amino acid deacetylation
Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic  acid.
positive regulation of protein amino acid deacetylation
Any process that modulates the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid.
regulation of chylomicron remodelling
Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
regulation of superoxide metabolism
Any process that modulates the rate, frequency, or extent of DNA-templated DNA replication, the process in which new strands of DNA are synthesized.
regulation of DNA-dependent DNA replication
Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells.
regulation of cell wall 1,3-beta-D-glucan biosynthetic process
regulation of cell wall 1,3-beta-glucan biosynthetic process