NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin.
2,3-oxidosqualene beta-amyrin cyclase
oxidosqualene:beta-amyrin cyclase activity
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
activation of protein import into nucleus
positive regulation of protein import into cell nucleus
positive regulation of protein transport from cytoplasm to nucleus
positive regulation of protein-nucleus import
stimulation of protein import into nucleus
up regulation of protein import into nucleus
up-regulation of protein import into nucleus
upregulation of protein import into nucleus
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
down regulation of protein import into nucleus
down-regulation of protein import into nucleus
downregulation of protein import into nucleus
inhibition of protein import into nucleus
negative regulation of protein import into cell nucleus
negative regulation of protein transport from cytoplasm to nucleus
negative regulation of protein-nucleus import
Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment.
antifreeze activity
ice nucleation activity
ice nucleation inhibitor activity
Any process resulting in the inhibition or termination of the activity of protein kinase C.
PKC deactivation
Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.
down regulation of circadian sleep/wake cycle, REM sleep
down-regulation of circadian sleep/wake cycle, REM sleep
downregulation of circadian sleep/wake cycle, REM sleep
inhibition of circadian sleep/wake cycle, REM sleep
negative regulation of REM sleep
Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep.
down regulation of circadian sleep/wake cycle, non-REM sleep
down-regulation of circadian sleep/wake cycle, non-REM sleep
downregulation of circadian sleep/wake cycle, non-REM sleep
inhibition of circadian sleep/wake cycle, non-REM sleep
negative regulation of non-REM sleep
Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate.
heparan sulphate N-acetylglucosaminyltransferase activity
heparin N-acetylglucosaminyltransferase activity
The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans.
structural constituent of cuticle
The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose.
taxis in response to oxidizable substrate
The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate.
taxis in response to electron acceptor
Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans.
collagen and cuticulin-based cuticle development during molting
cuticle anabolism during molting
cuticle biosynthetic process during molting
cuticle formation during molting
cuticle synthesis during molting
The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.
keratan sulfate breakdown
keratan sulfate catabolism
keratan sulfate degradation
keratan sulphate catabolic process
keratan sulphate catabolism
The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits.
cyanogenic glycoside breakdown
cyanogenic glycoside catabolism
cyanogenic glycoside degradation
The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan.
indole glucosinolate breakdown
indole glucosinolate catabolism
indole glucosinolate degradation
The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis.
dirigent protein
The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271).
\'de novo\' GDP-L-fucose anabolism
\'de novo\' GDP-L-fucose biosynthesis
\'de novo\' GDP-L-fucose formation
\'de novo\' GDP-L-fucose synthesis
GDP-L-fucose biosynthesis, de novo pathway
GDP-L-fucose biosynthetic process, de novo pathway
The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30).
GDP-L-fucose biosynthesis, salvage pathway
GDP-L-fucose biosynthetic process, salvage pathway
The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose).
L-fucose breakdown
L-fucose catabolism
L-fucose degradation
Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed.
GDP-4-keto-6-deoxy-D-mannose reductase activity
GDP-4-keto-D-rhamnose reductase activity
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity
guanosine diphosphate-4-keto-D-rhamnose reductase activity
The chemical reactions and pathways resulting in the breakdown of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.
thiamin diphosphate breakdown
thiamin diphosphate catabolic process
thiamin diphosphate catabolism
thiamin diphosphate degradation
thiamin pyrophosphate catabolic process
thiamin pyrophosphate catabolism
thiamine diphosphate catabolism
thiamine pyrophosphate catabolic process
thiamine pyrophosphate catabolism
TPP catabolic process
TPP catabolism
The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2.
menaquinone breakdown
menaquinone catabolism
menaquinone degradation
menatetrenone catabolic process
menatetrenone catabolism
multiprenylmenaquinone catabolic process
multiprenylmenaquinone catabolism
vitamin K2 catabolic process
vitamin K2 catabolism
The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
cobalamin breakdown
cobalamin catabolism
cobalamin degradation
vitamin B12 catabolic process
vitamin B12 catabolism
The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.
biotin breakdown
biotin catabolism
biotin degradation
vitamin B7 catabolic process
vitamin B7 catabolism
vitamin H catabolic process
vitamin H catabolism
The removal of one or more phosphate groups from thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.
thiamin diphosphate dephosphorylation
TPP dephosphorylation
The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants.
phylloquinone anabolism
phylloquinone biosynthesis
phylloquinone formation
phylloquinone synthesis
phytomenadione biosynthesis
phytomenadione biosynthetic process
phytonadione biosynthesis
phytonadione biosynthetic process
phytylmenaquinone biosynthesis
phytylmenaquinone biosynthetic process
vitamin K1 biosynthesis
vitamin K1 biosynthetic process
The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants.
phylloquinone breakdown
phylloquinone catabolism
phylloquinone degradation
phytomenadione catabolic process
phytomenadione catabolism
phytonadione catabolic process
phytonadione catabolism
phytylmenaquinone catabolic process
phytylmenaquinone catabolism
vitamin K1 catabolic process
vitamin K1 catabolism
Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.
(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)
Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response.
hemolymph clotting
The series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors.
gibberellic acid mediated signalling, G-alpha-dependent
The series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors.
gibberellic acid mediated signalling, G-alpha-independent
Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate.
sphingosine-1-phosphate phosphohydrolase activity
SPP phosphatase activity
SPPase activity
The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria.
ectoine breakdown
ectoine catabolism
ectoine degradation
The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
thyroid hormone breakdown
thyroid hormone catabolism
thyroid hormone degradation
The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic to endoplasmic reticulum membrane
extrinsic to ER membrane
Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA.
caffeoyl coenzyme A methyltransferase activity
caffeoyl-CoA 3-O-methyltransferase activity
S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity
trans-caffeoyl-CoA 3-O-methyltransferase activity
Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H+ + pimelyl-CoA.
6-carboxyhexanoate:CoA ligase (AMP-forming)
6-carboxyhexanoyl-CoA synthetase activity
pimeloyl-CoA synthetase activity
pimelyl-CoA synthetase activity
The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
carnitine breakdown
carnitine catabolism
carnitine degradation
vitamin Bt catabolic process
vitamin Bt catabolism
The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.
adrenaline biosynthesis
adrenaline biosynthetic process
epinephrine anabolism
epinephrine biosynthesis
epinephrine formation
epinephrine synthesis
The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
dopamine breakdown
dopamine catabolism
dopamine degradation
The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
levarterenol biosynthesis
levarterenol biosynthetic process
noradrenaline biosynthesis
noradrenaline biosynthetic process
norepinephrine anabolism
norepinephrine biosynthesis
norepinephrine formation
norepinephrine synthesis
The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
levarterenol catabolic process
levarterenol catabolism
noradrenaline catabolic process
noradrenaline catabolism
norepinephrine breakdown
norepinephrine catabolism
norepinephrine degradation
The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
choline breakdown
choline catabolism
choline degradation
The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
serotonin breakdown
serotonin catabolism
serotonin degradation
The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).
indole anabolism
indole biosynthesis
indole formation
indole synthesis
The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).
indole breakdown
indole catabolism
indole degradation
The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants.
IAA catabolic process
indole acetic acid catabolic process
indole acetic acid catabolism
indoleacetic acid breakdown
indoleacetic acid catabolism
indoleacetic acid degradation
The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine).
melatonin breakdown
melatonin catabolism
melatonin degradation
The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.
ethene catabolic process
ethene catabolism
ethylene breakdown
ethylene catabolism
ethylene degradation
Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus.
non-eye photoreceptor development
Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx.
down regulation of odontogenesis
down-regulation of odontogenesis
downregulation of odontogenesis
inhibition of odontogenesis
negative regulation of odontogenesis
negative regulation of odontogenesis of dentine-containing teeth
negative regulation of odontogenesis of dentine-containing tooth
The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups.
detection of triacylated bacterial lipoprotein
perception of triacylated bacterial lipopeptide
perception of triacylated bacterial lipoprotein
The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups.
detection of diacylated bacterial lipoprotein
perception of diacylated bacterial lipopeptide
perception of diacylated bacterial lipoprotein
Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups.
bacterial triacyl lipopeptide binding
bacterial triacyl lipoprotein binding
triacylated lipopeptide binding
Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups.
bacterial diacyl lipopeptide binding
bacterial diacyl lipoprotein binding
diacylated lipopeptide binding
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
activation of tyrosine phosphorylation of STAT protein
activation of tyrosine phosphorylation of Stat1 protein
activation of tyrosine phosphorylation of Stat2 protein
activation of tyrosine phosphorylation of Stat3 protein
activation of tyrosine phosphorylation of Stat4 protein
activation of tyrosine phosphorylation of Stat5 protein
activation of tyrosine phosphorylation of Stat6 protein
activation of tyrosine phosphorylation of Stat7 protein
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat2 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat4 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat6 protein
positive regulation of tyrosine phosphorylation of Stat7 protein
stimulation of tyrosine phosphorylation of STAT protein
stimulation of tyrosine phosphorylation of Stat1 protein
stimulation of tyrosine phosphorylation of Stat2 protein
stimulation of tyrosine phosphorylation of Stat3 protein
stimulation of tyrosine phosphorylation of Stat4 protein
stimulation of tyrosine phosphorylation of Stat5 protein
stimulation of tyrosine phosphorylation of Stat6 protein
stimulation of tyrosine phosphorylation of Stat7 protein
up regulation of tyrosine phosphorylation of STAT protein
up regulation of tyrosine phosphorylation of Stat1 protein
up regulation of tyrosine phosphorylation of Stat2 protein
up regulation of tyrosine phosphorylation of Stat3 protein
up regulation of tyrosine phosphorylation of Stat4 protein
up regulation of tyrosine phosphorylation of Stat5 protein
up regulation of tyrosine phosphorylation of Stat6 protein
up regulation of tyrosine phosphorylation of Stat7 protein
up-regulation of tyrosine phosphorylation of STAT protein
up-regulation of tyrosine phosphorylation of Stat1 protein
up-regulation of tyrosine phosphorylation of Stat2 protein
up-regulation of tyrosine phosphorylation of Stat3 protein
up-regulation of tyrosine phosphorylation of Stat4 protein
up-regulation of tyrosine phosphorylation of Stat5 protein
up-regulation of tyrosine phosphorylation of Stat6 protein
up-regulation of tyrosine phosphorylation of Stat7 protein
upregulation of tyrosine phosphorylation of STAT protein
upregulation of tyrosine phosphorylation of Stat1 protein
upregulation of tyrosine phosphorylation of Stat2 protein
upregulation of tyrosine phosphorylation of Stat3 protein
upregulation of tyrosine phosphorylation of Stat4 protein
upregulation of tyrosine phosphorylation of Stat5 protein
upregulation of tyrosine phosphorylation of Stat6 protein
upregulation of tyrosine phosphorylation of Stat7 protein
Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
down regulation of tyrosine phosphorylation of STAT protein
down regulation of tyrosine phosphorylation of Stat1 protein
down regulation of tyrosine phosphorylation of Stat2 protein
down regulation of tyrosine phosphorylation of Stat3 protein
down regulation of tyrosine phosphorylation of Stat4 protein
down regulation of tyrosine phosphorylation of Stat5 protein
down regulation of tyrosine phosphorylation of Stat6 protein
down regulation of tyrosine phosphorylation of Stat7 protein
down-regulation of tyrosine phosphorylation of STAT protein
down-regulation of tyrosine phosphorylation of Stat1 protein
down-regulation of tyrosine phosphorylation of Stat2 protein
down-regulation of tyrosine phosphorylation of Stat3 protein
down-regulation of tyrosine phosphorylation of Stat4 protein
down-regulation of tyrosine phosphorylation of Stat5 protein
down-regulation of tyrosine phosphorylation of Stat6 protein
down-regulation of tyrosine phosphorylation of Stat7 protein
downregulation of tyrosine phosphorylation of STAT protein
downregulation of tyrosine phosphorylation of Stat1 protein
downregulation of tyrosine phosphorylation of Stat2 protein
downregulation of tyrosine phosphorylation of Stat3 protein
downregulation of tyrosine phosphorylation of Stat4 protein
downregulation of tyrosine phosphorylation of Stat5 protein
downregulation of tyrosine phosphorylation of Stat6 protein
downregulation of tyrosine phosphorylation of Stat7 protein
inhibition of tyrosine phosphorylation of STAT protein
inhibition of tyrosine phosphorylation of Stat1 protein
inhibition of tyrosine phosphorylation of Stat2 protein
inhibition of tyrosine phosphorylation of Stat3 protein
inhibition of tyrosine phosphorylation of Stat4 protein
inhibition of tyrosine phosphorylation of Stat5 protein
inhibition of tyrosine phosphorylation of Stat6 protein
inhibition of tyrosine phosphorylation of Stat7 protein
negative regulation of tyrosine phosphorylation of Stat1 protein
negative regulation of tyrosine phosphorylation of Stat2 protein
negative regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of tyrosine phosphorylation of Stat4 protein
negative regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of tyrosine phosphorylation of Stat6 protein
negative regulation of tyrosine phosphorylation of Stat7 protein
The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids.
haemoglobin catabolic process
haemoglobin catabolism
haemoglobin hydrolysis
hemoglobin breakdown
hemoglobin catabolism
hemoglobin degradation
hemoglobin hydrolysis
The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose.
melibiose anabolism
melibiose biosynthesis
melibiose formation
melibiose synthesis
Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase.
eEF-2 kinase activator
A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development.
IGF ternary complex
A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development.
IGF binary complex