NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine.
PRMT activity
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
protein (lysine) methyltransferase activity
protein lysine methylase activity
Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+.
CoA hydrolase activity
Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule.
tRNA (uracil) methyltransferase activity
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
phosphokinase activity
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
axon pruning
neuron remodelling
neuronal remodeling
Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster.
oocyte microtubule cytoskeleton organisation
The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction.
calcium-independent cell adhesion molecule activity
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
calcium-dependent cell adhesion molecule activity
The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis.
chromosome migration to spindle pole during meiosis
chromosome movement towards spindle pole during meiosis
meiotic chromosome movement
meiotic chromosome movement to spindle pole
Catalysis of the transfer of an acetyl group to an acceptor molecule.
acetylase activity
Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine.
tRNA (guanosine) methyltransferase activity
Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine.
tRNA (adenine-C2-)-methyltransferase activity
Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine.
tRNA (cytosine) methyltransferase activity
The inactivation of gene expression that occurs after transcription.
posttranscriptional gene silencing
PTGS
The somatic process that results in the generation of sequence diversity of immunoglobulins.
somatic diversification of antibodies
Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
somatic hypermutation of antibody genes
The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.
somatic recombination of antibody gene segments
A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures.
conventional myosin
A portmanteau term for myosins other than myosin II.
non-muscle myosin
A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.
hydrogen-transporting two-sector ATPase complex
vacuolar hydrogen-transporting ATPase
A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.
vacuolar hydrogen-translocating V-type ATPase complex
A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis.
sodium-transporting two-sector ATPase complex
Any process that modulates the surface configuration of an embryonic cell.
shape changes of embryonic cells
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I.
down regulation of transcription from RNA polymerase I promoter
down-regulation of transcription from RNA polymerase I promoter
downregulation of transcription from RNA polymerase I promoter
inhibition of transcription from RNA polymerase I promoter
negative regulation of transcription from Pol I promoter
negative regulation of transcription from RNA polymerase I promoter
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III.
down regulation of transcription from RNA polymerase III promoter
down-regulation of transcription from RNA polymerase III promoter
downregulation of transcription from RNA polymerase III promoter
inhibition of transcription from RNA polymerase III promoter
negative regulation of transcription from Pol III promoter
negative regulation of transcription from RNA polymerase III promoter
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
peptidolysis during protein maturation
protein maturation by peptide bond cleavage
protein maturation by peptide bond hydrolysis
protein maturation by proteolysis
The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol.
farnesol metabolism
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
oxidoreductase activity, acting on other substrates
redox activity
Binds to and increases the activity of a peptidase.
protease activator activity
Binds to and increases the activity of a peptidase that is involved in the apoptotic process.
apoptotic protease activator activity
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
down regulation of angiogenesis
down-regulation of angiogenesis
downregulation of angiogenesis
inhibition of angiogenesis
Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.
cyclin
cyclin-dependent protein kinase regulator activity
cyclin-dependent protein kinase, intrinsic regulator activity
G1/S-specific cyclin
G2/M-specific cyclin
The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues.
intein
The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster.
male courtship behavior, wing vibration
male courtship behaviour, veined wing vibration
male courtship behaviour, wing vibration
Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s).
base conversion/substitution editing
The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.
mRNA editing
The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix.
peroxisome matrix protein import
protein transport to peroxisome matrix
The process in which one or more ubiquitin groups are added to a protein.
protein ubiquitinylation
protein ubiquitylation
The removal of one or more ubiquitin groups from a protein.
deubiquitination
protein deubiquitinylation
protein deubiquitylation
An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
Mi-2 complex
NRD complex
nucleosome remodeling and histone deacetylation complex
A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters.
DNA-directed RNA polymerase II, holoenzyme
An intracellular signaling cassette in which a small monomeric GTPase of the Rac subfamily relays a signal.
Rac mediated signal transduction
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nuclear speckle
nuclear speckles
speckle domain
speckle focus
splicing speckle
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on the CH-OH group of donors, other acceptors
Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+.
beta-hydroxypyruvate reductase activity
D-glycerate dehydrogenase activity
D-glycerate:NADP+ 2-oxidoreductase activity
hydroxypyruvate reductase activity
NADH:hydroxypyruvate reductase activity
Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide.
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein.
oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on the CH-CH group of donors, other acceptors
Catalysis of the reaction: acyl- + NAD(P)+ = trans-2,3-dehydroacyl- + NAD(P)H + H+.
enoyl- reductase activity
enoyl- reductase activity
enoyl-ACP reductase activity
enoyl-acyl carrier protein reductase
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein.
oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group.
oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein.
oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on the CH-NH group of donors, other acceptors
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide.
oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
NAD(P)H dehydrogenase
oxidoreductase activity, acting on NADH or NADPH
oxidoreductase activity, acting on NADH or NADPH, other acceptor
Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP.
oxidoreductase activity, acting on NAD or NADPH, NAD or NADP as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein.
oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor
oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors
Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein.
oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on sulfur group of donors, other acceptors
oxidoreductase activity, acting on sulphur group of donors
Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP.
oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor
oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor
oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor
oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome.
oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen.
oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide.
oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound.
oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein.
oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on haem group of donors
oxidoreductase activity, acting on heme group of donors, other acceptors
Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group.
oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors
Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen.
laccase activity
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor.
oxidoreductase activity, acting on hydrogen as donor, other acceptors
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein.
oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor.
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous
oxygenase
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
2-oxoglutarate dioxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor.
aryl hydrocarbon hydroxylase activity
aryl-4-monooxygenase activity
cytochrome p450 activity
cytochrome P450 CYP19
flavoprotein monooxygenase activity
flavoprotein-linked monooxygenase activity
microsomal monooxygenase activity
microsomal P-450
microsomal p450 activity
substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
unspecific monooxygenase activity
xenobiotic monooxygenase activity
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen
Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered.
oxidoreductase activity, oxidizing metal ions
oxidoreductase activity, reducing metal ions
Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor.
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
oxidoreductase activity, reducing metal ions, NAD or NADP as acceptor
Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor.
oxidoreductase activity, oxidizing metal ions, oxygen as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on CH or CH2 groups, other acceptors
Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group.
oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on iron-sulphur proteins as donors
Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor).
methyltransferase activity
Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor).
carboxyl- and carbamoyltransferase activity
Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor).
transferase activity, transferring aldehyde or ketonic groups
Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
transferase activity, transferring acyl groups
Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
transferase activity, transferring acyl groups other than amino-acyl groups
transferase activity, transferring groups other than amino-acyl groups
Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor).
transferase activity, transferring amino-acyl groups
Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
transferase activity, transferring glycosyl groups
transferase activity, transferring other glycosyl groups
transglycosidase activity
transglycosylase activity
Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).
transferase activity, transferring hexosyl groups