NothingMuch/GO-Terms huggingface dataset:
Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
negative regulation of lamellipodium biogenesis
A process leading to the generation of a functional long small interfering RNA (lsiRNA). lsiRNAs are class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions.
primary lsiRNA processing
production of lsiRNA involved in RNA interference
RNA interference, production of lsiRNA
Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintenance in, a specific location within the cell.
mRNA localisation resulting in posttranscriptional regulation of gene expression
mRNA localization resulting in posttranscriptional regulation of gene expression
posttranscriptional regulation of gene expression by mRNA localisation
posttranscriptional regulation of gene expression by mRNA localization
Any process that modulates the concentration of cytosolic free calcium ion cyt with a regularity of approximately 24 hours.
circadian regulation of cyt oscillation
circadian regulation of Ca2+ oscillation
circadian regulation of cytosolic calcium ion homeostasis
circadian regulation of cytosolic free calcium ion oscillation
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor.
negative regulation of transcription by transcription factor localisation
Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
positive regulation of cardiac muscle cell apoptosis
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
down regulation of cardiac muscle cell apoptosis
down-regulation of cardiac muscle cell apoptosis
downregulation of cardiac muscle cell apoptosis
inhibition of cardiac muscle cell apoptosis
negative regulation of cardiac muscle cell apoptosis
The chemical reactions and pathways resulting in the breakdown of tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings.
tricyclic triterpenoid catabolism
Any process that increases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane.
positive regulation of SPB separation
Any process that decreases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane.
negative regulation of SPB separation
Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule.
acetyltransferase stimulator activity
The chemical reactions and pathways resulting in the formation of gangliosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group.
biosynthesis of lactosylceramide precursor to ganglioside
ganglioside biosynthesis via lactosylceramide biosynthesis
lactosylceramide biosynthesis leading to ganglioside
lactosylceramide biosynthetic process leading to ganglioside
The chemical reactions and pathways resulting in the formation of globosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group.
biosynthesis of lactosylceramide precursor to globoside
globoside biosynthesis via lactosylceramide biosynthesis
lactosylceramide biosynthesis leading to globoside
lactosylceramide biosynthetic process leading to globoside
Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.
down regulation of collagen catabolic process
down-regulation of collagen catabolic process
downregulation of collagen catabolic process
inhibition of collagen catabolic process
negative regulation of collagen breakdown
negative regulation of collagen catabolism
negative regulation of collagen degradation
Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
down regulation of extracellular matrix disassembly
down-regulation of extracellular matrix disassembly
downregulation of extracellular matrix disassembly
inhibition of extracellular matrix disassembly
negative regulation of extracellular matrix breakdown
negative regulation of extracellular matrix degradation
Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis.
regulation of definitive erythropoiesis
regulation of definitive RBC differentiation
regulation of definitive red blood cell differentiation
Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis.
regulation of primitive erythropoeisis
regulation of primitive RBC differentiation
regulation of primitive red blood cell differentiation
Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
positive regulation of hydrogen peroxide biosynthesis
Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
negative regulation of hydrogen peroxide biosynthesis
Any process that increases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.
positive regulation of protein amino acid glutathionylation
Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.
negative regulation of protein amino acid glutathionylation
Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
positive regulation of PKA signaling cascade
positive regulation of protein kinase A signaling cascade
positive regulation of protein kinase A signalling cascade
Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
positive regulation of plasma membrane long-chain fatty acid transport
Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane.
negative regulation of plasma membrane long-chain fatty acid transport
Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.
inhibition of plasminogen activation
Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
negative regulation of TNF signaling
negative regulation of TNF-mediated signaling pathway
negative regulation of tumor necrosis factor-mediated signalling pathway
Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.
negative regulation of protein amino acid ADP-ribosylation
Binding to a genomic region which promotes recombination.
DNA binding, recombination hotspot
Any process that starts the inactive process of reciprocal meiotic recombination. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.
activation of meiotic recombination
Any process that modulates the rate of ATP hydrolysis by an ATPase. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.
regulation of hydrogen ion transporting ATPase activity, rotational mechanism
regulation of V-type ATPase activity
A series of reactions within the cell that occur as a result of a single trigger reaction or compound interacting with a chemoreceptor resulting in a modulation of the force with which blood travels through the circulatory system. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.
regulation of blood pressure by chemoreceptor signalling pathway
Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
positive regulation of triacylglycerol biosynthetic process
Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
negative regulation of triacylglycerol biosynthetic process
Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
positive regulation of cholesterol sequestration
Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
negative regulation of cholesterol sequestration
Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.
positive regulation of sequestering of triacylglycerol
positive regulation of triglyceride sequestration
Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.
negative regulation of sequestering of triacylglycerol
negative regulation of triglyceride sequestration
Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
negative regulation of triacylglycerol catabolic process
Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
positive regulation of triacylglycerol catabolic process
Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid.
positive regulation of very-low-density lipoprotein particle remodelling
positive regulation of VLDL remodeling
positive regulation of VLDL remodelling
Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid.
negative regulation of very-low-density lipoprotein particle remodelling
negative regulation of VLDL remodeling
negative regulation of VLDL remodelling
Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate.
negative regulation of UDP-glucose catabolism
Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
negative regulation of VLDL clearance
negative regulation of VLDL particle clearance
Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
reduction of mitochondrial membrane potential
Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
elevation of mitochondrial membrane potential
Any process that increases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin.
positive regulation of auxin mediated signalling pathway
Any process that decreases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin.
negative regulation of auxin mediated signalling pathway
Catalysis of the reaction: an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+. This reaction can also use coenzyme A as a substrate.
CoA diphosphatase activity
CoA pyrophosphatase activity
coenzyme A pyrophosphatase activity
A homeostatic process involved in the maintenance of a steady state level of magnesium ions within a cell.
cellular magnesium ion homeostasis
Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.
APC binding
The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER.
Golgi to endoplasmic reticulum transport vesicle membrane
Golgi to ER constitutive secretory pathway transport vesicle membrane
Golgi-endoplasmic reticulum transport vesicle membrane
Golgi-ER transport vesicle membrane
The lipid bilayer surrounding a vesicle transporting substances within the Golgi.
inter-Golgi transport constitutive secretory pathway transport vesicle membrane
The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
microglial cell development
Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell.
down regulation of microglia differentiation
down-regulation of microglia differentiation
downregulation of microglia differentiation
inhibition of microglia differentiation
negative regulation of microglial cell differentiation
Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell.
activation of microglia differentiation
positive regulation of microglial cell differentiation
stimulation of microglia differentiation
up regulation of microglia differentiation
up-regulation of microglia differentiation
upregulation of microglia differentiation
The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals.
medullary cord biosynthesis
medullary cord formation
medullary rod cavitation
neural rod formation
secondary neural tube rod cavitation
secondary neurulation
Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation.
down regulation of Schwann cell differentiation
down-regulation of Schwann cell differentiation
downregulation of Schwann cell differentiation
inhibition of Schwann cell differentiation
Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation.
activation of Schwann cell differentiation
stimulation of Schwann cell differentiation
up regulation of Schwann cell differentiation
up-regulation of Schwann cell differentiation
upregulation of Schwann cell differentiation
Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.
establishment of endothelial BBB
establishment of endothelial blood/brain barrier
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.
down regulation of gamma-aminobutyric acid secretion
down-regulation of gamma-aminobutyric acid secretion
downregulation of gamma-aminobutyric acid secretion
inhibition of gamma-aminobutyric acid secretion
negative regulation of GABA secretion
Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.
activation of gamma-aminobutyric acid secretion
positive regulation of GABA secretion
stimulation of gamma-aminobutyric acid secretion
up regulation of gamma-aminobutyric acid secretion
up-regulation of gamma-aminobutyric acid secretion
upregulation of gamma-aminobutyric acid secretion
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine.
down regulation of acetylcholine secretion
down-regulation of acetylcholine secretion
downregulation of acetylcholine secretion
inhibition of acetylcholine secretion
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.
down regulation of serotonin secretion
down-regulation of serotonin secretion
downregulation of serotonin secretion
inhibition of serotonin secretion
positive regulation of serotonin release
Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin.
activation of serotonin secretion
positive regulation of serotonin release
stimulation of serotonin secretion
up regulation of serotonin secretion
up-regulation of serotonin secretion
upregulation of serotonin secretion
Skeletal muscle satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt.
satellite cell asymmetric division involved in skeletal muscle regeneration
Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril.
regulation of calcium ion sensitivity of myofibril involved in skeletal muscle contraction
The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
mononucleate cell migration involved in skeletal muscle regeneration
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract.
oesophagus smooth muscle contraction
Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
regulation of excitatory post-synaptic membrane potential involved in skeletal muscle contraction
The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
neurotransmitter secretion involved in control of skeletal muscle contraction
Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes.
regulation of skeletal muscle contraction via membrane action potential
The series of events by which a muscle activity stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation.
detection of fatigue