NothingMuch/GO-Terms huggingface dataset:
Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity.
PGF receptor activity
PGF(2-alpha) receptor activity
Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein.
TXA(2) receptor activity
TXA2 receptor activity
Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
endothelin-A receptor activity
endothelin-B receptor activity
Combining with follicle-stimulating hormone to initiate a change in cell activity.
follicle stimulating hormone receptor activity
FSH receptor activity
Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity.
LH receptor
LHR
lutropin receptor
lutropin-choriogonadotropic hormone receptor
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
G-protein coupled GABA receptor activity
GABA-B receptor activity
metabotropic GABA receptor
Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
GnRH receptor activity
gonadotrophin-releasing hormone receptor activity
An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium.
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
AMPA receptor activity
A cation channel that opens in response to binding by extracellular glutmate, but only if glycine or D-serine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages.
N-methyl-D-aspartate selective glutamate receptor activity
NMDA receptor
Combining with corticotropin to initiate a change in cell activity.
ACTH receptor activity
adrenocorticotropic hormone receptor activity
adrenocorticotropin receptor activity
Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC).
mu-opioid receptor activity
Combining with melanocyte-stimulating hormone to initiate a change in cell activity.
melanocyte stimulating hormone receptor activity
melanophore-stimulating hormone receptor activity
MSH receptor activity
MSHR activity
Combining with an N-formyl peptide to initiate a change in cell activity.
Fmet-leu-phe receptor
Combining with platelet activating factor to initiate a change in cell activity.
PAF receptor activity
Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28).
GHIH receptor activity
growth hormone-inhibiting hormone receptor activity
somatotrophin release inhibiting factor receptor activity
SRIF receptor activity
SST receptor activity
Combining with thyroid-stimulating hormone to initiate a change in cell activity.
thyroid stimulating hormone receptor activity
thyrotropin receptor
TSH receptor activity
Combining with vasopressin to initiate a change in cell activity.
vasopressin activated calcium mobilizing receptor activity
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
GPI-linked Eph receptor activity
Combining with a transmembrane ephrin to initiate a change in cell activity.
transmembrane-Eph receptor activity
Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
EGF receptor activity
EGFR
epidermal growth factor-activated receptor activity
TGF-alpha receptor activity
transforming growth factor-alpha receptor activity
Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
FGF receptor activity
FGF-activated receptor activity
FGFR
fibroblast growth factor-activated receptor activity
Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
hepatocyte growth factor-activated receptor activity
HGF receptor activity
HGF-activated receptor activity
Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
insulin-activated receptor activity
Combining with insulin-like growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
IGF receptor activity
IGF-activated receptor activity
insulin-like growth factor-activated receptor activity
Combining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
CSF-1
Fms
M-CSF receptor activity
macrophage colony stimulating factor receptor activity
Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity.
alphaPDGF receptor activity
PDGF alpha-receptor activity
Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity.
betaPDGF receptor activity
PDGF beta-receptor activity
Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.
KIT
KIT ligand receptor activity
KL receptor activity
SCF receptor activity
Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
vascular endothelial growth factor E-activated receptor activity
vascular endothelial growth factor-activated receptor activity
VEGF receptor activity
VEGF-A-activated receptor activity
VEGF-activated receptor activity
VEGF-B-activated receptor activity
VEGF-C-activated receptor activity
VEGF-D-activated receptor activity
VEGF-E-activated receptor activity
VEGFR activity
Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals.
transforming growth factor beta ligand binding to type I receptor
type I TGF-beta receptor activity
type I TGFbeta receptor activity
type I transforming growth factor beta receptor activity
Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor.
transforming growth factor beta ligand binding to type II receptor
type II TGF-beta receptor activity
type II TGFbeta receptor activity
type II transforming growth factor beta receptor activity
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
NGF/TNF (6 C-domain) receptor activity
TNF receptor activity
TNF receptor activity, type I
TNF receptor activity, type II
tumor necrosis factor receptor activity, type I
tumor necrosis factor receptor activity, type II
tumor necrosis factor-activated receptor activity
Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.
LDL receptor
LDLR activity
low-density lipoprotein receptor activity
Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin.
netrin receptor activity involved in negative chemotaxis
repulsive netrin receptor activity
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
macrophage receptor activity
Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.
KDEL receptor activity
Binding to a signal recognition particle.
docking protein
signal recognition particle receptor
Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
exportin activity
importin-alpha binding
importin-alpha export receptor activity
NES receptor
Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L.
peroxisomal targeting signal 1 (PTS1) binding
peroxisome targeting signal-1 binding
peroxisome targeting signal-1 receptor
PEX5
PTS1 binding
PTS1 receptor
Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F).
peroxisomal targeting signal 2 (PTS2) binding
peroxisome targeting signal-2 binding
peroxisome targeting signal-2 receptor
PEX7
PTS2 binding
PTS2 receptor
The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.
transmembrane receptor protein tyrosine kinase adaptor protein activity
transmembrane receptor protein tyrosine kinase docking protein activity
The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
MAP-kinase scaffold protein activity
Binding to protein kinase C.
PKC alpha binding
PKC binding
PKC delta binding
PKC eta binding
protein kinase C alpha binding
protein kinase C delta binding
protein kinase C eta binding
Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
ARF guanyl-nucleotide exchange factor activity
cAMP-dependent guanyl-nucleotide exchange factor activity
GDP-dissociation stimulator activity
GDS
GEF
GNRP
guanyl-nucleotide release factor activity
guanyl-nucleotide releasing factor
Rab guanyl-nucleotide exchange factor activity
Rac guanyl-nucleotide exchange factor activity
Ral guanyl-nucleotide exchange factor activity
Ran guanyl-nucleotide exchange factor activity
Rap guanyl-nucleotide exchange factor activity
Ras guanyl-nucleotide exchange factor activity
Rho guanine nucleotide exchange factor
Rho guanyl-nucleotide exchange factor activity
RhoGEF
Sar guanyl-nucleotide exchange factor activity
Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.
GIP
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
ARF GAP activity
ARF GTPase activator activity
GAP activity
Rab GAP activity
Rab GTPase activator activity
Rac GAP activity
Rac GTPase activator activity
Ral GAP activity
Ral GTPase activator activity
Ran GAP activity
Ran GTPase activator activity
RanGAP
Rap GAP activity
Rap GTPase activator activity
Ras GAP activity
Ras GTPase activator activity
Rho GAP activity
Rho GTPase activator activity
Sar GAP activity
Sar GTPase activator activity
Binding to a type 1 fibroblast growth factor receptor (FGFR1).
breathless binding
breathless ligand
FGFR1 binding
FGFR1 ligand
type 1 fibroblast growth factor receptor ligand
Binding to a frizzled (fz) receptor.
frizzled ligand
frizzled-2 binding
frizzled-2 ligand
fz binding
fz ligand
fz2 binding
fz2 ligand
Binding to a type 2 fibroblast growth factor receptor (FGFR2).
FGFR2 binding
FGFR2 ligand
heartless binding
heartless ligand
type 2 fibroblast growth factor receptor ligand
Binding to a Notch (N) protein, a surface receptor.
N binding
N ligand
Notch ligand
Notch receptor binding
Binding to a patched (ptc) protein, a receptor for hedgehog proteins.
patched ligand
ptc binding
ptc ligand
Binding to a type II transforming growth factor beta receptor.
punt binding
punt ligand
TGF-beta type II binding
transforming growth factor beta ligand binding to type II receptor
transforming growth factor beta receptor type II binding
type II TGF-beta binding
Binding to a receptor tyrosine kinase-like orphan receptor (Ror).
receptor tyrosine kinase-like orphan receptor ligand
Ror binding
Ror ligand
Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor.
SE20 receptor binding
wishful thinking ligand
Wit binding
Wit ligand
Binding to a sevenless (sev) protein, a receptor tyrosine kinase.
sev binding
sev ligand
sevenless ligand
Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals.
smo binding
smo ligand
smoothened ligand
Binding to a Toll protein, a transmembrane receptor.
Tl binding
Toll ligand
Toll receptor binding
Binding to a torso (tor) protein, a receptor tyrosine kinase.
tor binding
tor ligand
torso ligand
Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles.
scavenger receptor ligand
Binding to a ciliary neurotrophic factor receptor.
ciliary neurotrophic factor
ciliary neurotrophic factor receptor ligand
Binding to an erythropoietin receptor.
erythropoietin
erythropoietin receptor ligand
Binding to a granulocyte macrophage colony-stimulating factor receptor.
GM-CSF receptor binding
GM-CSF receptor ligand
GMC-SF receptor ligand
granulocyte macrophage colony stimulating factor receptor binding
granulocyte macrophage colony-stimulating factor
granulocyte macrophage colony-stimulating factor receptor ligand
Binding to a granulocyte colony-stimulating factor receptor.
G-CSF receptor ligand
GC-SF receptor ligand
granulocyte colony stimulating factor receptor binding
granulocyte colony-stimulating factor
granulocyte colony-stimulating factor receptor ligand
Binding to a growth hormone receptor.
growth hormone
growth hormone receptor ligand
Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2).
IFNAR binding
IFNAR1 binding
IFNAR2 binding
interferon-alpha/beta
interferon-alpha/beta receptor binding
interferon-alpha/beta receptor ligand
Binding to a type II interferon receptor. Type II interferon is also known as interferon-gamma.
interferon-gamma
interferon-gamma receptor binding
interferon-gamma receptor ligand
Binding to an interleukin-2 receptor.
IL-2
interleukin-2 receptor ligand
Binding to an interleukin-3 receptor.
IL-3
interleukin-3 receptor ligand
Binding to an interleukin-4 receptor.
IL-4
interleukin-4 receptor ligand
Binding to an interleukin-5 receptor.
IL-5
interleukin-5 receptor ligand
Binding to an interleukin-6 receptor.
IL-6
interleukin-6 receptor ligand
Binding to an interleukin-7 receptor.
IL-7
interleukin-7 receptor ligand
Binding to an interleukin-9 receptor.
IL-9
interleukin-9 receptor ligand
Binding to an interleukin-10 receptor.
IL-10
interleukin-10 receptor ligand
Binding to an interleukin-11 receptor.
IL-11
interleukin-11 receptor ligand
Binding to an interleukin-12 receptor.
IL-12
interleukin-12 receptor ligand
Binding to an interleukin-13 receptor.
IL-13
interleukin-13 receptor ligand
Binding to an leukemia inhibitory factor receptor.
leukemia inhibitory factor
leukemia inhibitory factor receptor ligand
Binding to an oncostatin-M receptor.
oncostatin-M
oncostatin-M receptor ligand
Binding to a prolactin receptor.
prolactin
prolactin receptor ligand
Binding to a Type I interleukin-1 receptor.
IL-1 type I
interleukin-1, type I receptor ligand
Binding to a Type II interleukin-1 receptor.
IL-1 type II
interleukin-1, type II receptor ligand
Binding to an epidermal growth factor receptor.
EGF
EGF receptor binding
EGF receptor ligand
EGFR binding
epidermal growth factor
epidermal growth factor receptor ligand
TGF-alpha receptor binding
TGFalpha receptor binding
transforming growth factor alpha
transforming growth factor alpha receptor binding
transforming growth factor alpha receptor ligand
Binding to a macrophage colony-stimulating factor receptor.
M-CSF receptor binding
macrophage colony stimulating factor receptor binding
macrophage colony-stimulating factor receptor ligand
Binding to an insulin receptor.
insulin receptor ligand
Binding to an insulin-like growth factor receptor.
IGF receptor binding
insulin-like growth factor
insulin-like growth factor receptor ligand
Binding to a platelet-derived growth factor receptor.
PDGF
PDGF receptor binding
PDGFR binding
platelet-derived growth factor
platelet-derived growth factor receptor ligand
Binding to a nerve growth factor receptor.
nerve growth factor receptor ligand
neurotrophin
NGF receptor binding
Binding to a tumor necrosis factor receptor.
TNF receptor binding
tumor necrosis factor
tumor necrosis factor receptor ligand
Binding to a neurotrophin p75 receptor.
neurotrophin p75 receptor ligand
Binding to a neurotrophin TRKA receptor.
neurotrophin TRKA receptor ligand
Binding to a neurotrophin TRKB receptor.
neurotrophin TRKB receptor ligand
Binding to a neurotrophin TRKC receptor.
neurotrophin TRKC receptor ligand
Binding to an hepatocyte growth factor receptor.
hepatocyte growth factor
hepatocyte growth factor receptor ligand
HGF receptor binding
Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.
KIT binding
SCF
SCFR binding
stem cell factor
stem cell factor receptor ligand
Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2.
ErbB-2 class receptor ligand
HER2 receptor binding
HER2 receptor ligand
Neu receptor binding
Neu receptor ligand
The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary.
GnRH activity
gonadotrophin hormone-releasing hormone activity
LH/FSH-RF
LHRH activity
luteinizing hormone-releasing factor activity
luteinizing hormone-releasing hormone activity
luteinizing hormone/follicle-stimulating hormone releasing factor activity
The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin.
neurohypophysial hormone activity
The action of a molecule that contributes to the structural integrity of an egg chorion. An example of this is found in Drosophila melanogaster.
structural constituent of chorion
structural protein of chorion
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts.
intracellular cGMP activated cation channel activity
intracellular cGMP-activated cation channel activity
Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification.
intracellular sodium activated potassium channel activity
Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
intracellular calcium activated chloride channel activity
Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane.
CFTR
channel-conductance-controlling ATPase activity
cystic fibrosis transmembrane conductance regulator
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport.
allantoin permease activity
allantoin uptake transmembrane transporter activity
allantoin/allantoate transporter
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out).
acetylcholine:hydrogen antiporter activity
Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high affinity arginine transmembrane transporter activity
high-affinity arginine transmembrane transporter activity
high-affinity arginine transporter activity
Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high affinity histidine permease activity
high affinity L-histidine transmembrane transporter activity
Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high affinity lysine transmembrane transporter activity
high affinity lysine transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in).
hydrogen/proline transporter
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in).
sodium/proline symporter activity
Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high-affinity tryptophan transporter activity