NothingMuch/GO-Terms huggingface dataset:
Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis.
dense core vesicle maturation
A specialized secretory organelle found in neurons and associated with the formation of dendrodendritic gap junctions.
DLB
A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle.
mitotic DNA-dependent DNA replication
Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8.
CDK8 kinase module
SRB8-SRB11 complex
SRB8/9/10/11 complex
Protein complex involved in the disassembly of Mago-Y14 from the spliced mRNA during first round of translation, independently of the translational machinery. Conserved from fission yeast to humans.
PYM-mago-RNA-binding protein 8A complex
wibg-mago-tsu complex
Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms.
CLOCK/BMAL complex
The process in which a pyrimidine nucleotide is transported across the mitochondrial inner membrane, into the mitochondrial matrix.
mitochondrial pyrimidine nucleotide import
A protein complex that includes separase (a protease which cleaves cohesin as part of chromosome separation) and securin, a protease inhibitor. Chromosome separation is inhibited until securin is degraded by the Anaphase Promoting Complex (APC).
Cut1-2 complex
A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p.
INAC
Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain.
Baculovirus Inhibitor of apoptosis protein Repeat domain binding
A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M.
GPI-MT-I complex
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus.
response to nickel ion stress
response to nickel toxicity
stress response to nickel
A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay.
Dom34:Hbs1 complex
The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
axon homeostasis
axon maintenance
neurite maintenance
neuron process maintenance
neuron protrusion maintenance
neuronal cell projection maintenance
The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol.
fructose import
fructose uptake
The process in which alpha-ketoglutarate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial 2-oxoglutarate transmembrane transport
An exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery.
exosome complex
An inward rectifier potassium channel complex expressed in cardiac muscle, specifically the sinoatrial node and atria, where it controls the heart rate, via regulation by G protein-coupled receptor signaling. In mammals it is composed of GIRK1 (or Kir3.1) and GIRK4 (or Kir3.4) subunits.
GIRK1-GIRK4 G protein-coupled atrial inward rectifier potassium channel complex
Kir3.1-Kir3.4 G protein-coupled atrial inward rectifier potassium channel complex
muscarinic potassium channel complex
The process in which UDP-N-acetylglucosamine is transported across a membrane.
UDP-N-acetylglucosamine transport
The process in which GDP-mannose is transported across a membrane.
GDP-mannose transport
The process by which centromeres/kinetochores attach to and migrate along microtubules to become localized to clusters at the spindle pole body during a meiotic prometaphase I.
centromere clustering during meiosis
homologous chromosome movement towards spindle pole in meiosis I prometaphase
A ribonucleoprotein complex that has RNA-directed RNA polymerase (RdRP) activity, and is composed of telomerase reverse transcriptase (TERT) and the non-coding RNA component of mitochondrial RNA processing endoribonuclease (RMRP).
telomerase reverse transcriptase:RMRP RNA complex
The process in which L-ornithine is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial ornithine transmembrane transport
mitochondrial ornithine transport
Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
G-protein coupled glucose receptor activity
The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus.
perinuclear ER membrane
The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer.
serine autophosphorylation in trans
serine transautophosphorylation
A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction.
cTnC:cTnI:cTnT
Catalysis of the reaction: trans-4-hydroxy-L-prolyl- + UDP-beta-L-arabinofuranose = H+ + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl- + UDP.
HPAT
A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB and FtsL.
FtsB-FtsL complex
Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.
NAC binding
NACA binding
Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O.
L-talarate dehydratase activity
A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein).
AIP1-ERN1 complex
IRE1-DAB2IP complex
IRE1alpha-AIP1 complex
A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K).
ERN1-TRAF2-ASK1 complex
A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p.
Bud14-Kel1-Kel2 complex
KFRC complex
The directed movement of magnesium ions out of mitochondrial matrix into the cytosol by means of some agent such as a transporter or pore.
magnesium ion efflux from mitochondrion
A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits.
ATF4-CHOP heterodimer
CHOP-ATF4 heterodimer
CHOP-CREB-2 complex
CHOP/ATF4 complex
GADD153-ATF4 complex
A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure.
NPR1 receptor complex
An ESCRT complex that has AAA-ATPase activity and is involved in ESCRT-mediated intralumenal vesicle formation and the final stages of cytokinesis. The complex catalyzes disassembly of the ESCRT III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1.
ESCRT-IV
vacuolar protein sorting-associated complex
Vps4 complex
Vps4-Vta1 complex
VPS4A-VPS4B
VPS4A/B complex
Vta1-Vps4 complex
A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits.
ATF3-CHOP complex
CHOP-ATF3 heterodimer
CHOP-ATF3 heterodimeric complex
GADD153-ATF3 complex
The dilated terminal portions of neurosecretory axons constituting the hypothalamohypophyseal tract, found in close proximity to sinusoidal capillaries in the posterior pituitary. Herring bodies consist of aggregates of membrane-bound neurosecretory vesicles where oxytocin or antidiuretic hormone (ADH) are stored prior to release. Each Herring body also contains ATP and either neurophysin I or neurophysin II which bind to oxytocin and ADH, respectively.
neurosecretory body
The membrane organization process that joins two mitochondrial outer membranes to form a single membrane.
mitochondrion outer membrane fusion
The membrane organization process that joins two mitochondrial inner membranes to form a single membrane.
mitochondrion inner membrane fusion
A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels.
cardiac phospholamban complex
cardiac PLB complex
cardiac PLN complex
A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A.
ERN1-RACK1-PP2A complex
IRE1alpha-RACK1-PP2A complex
Binding to the protein-tyrosine kinase receptor ErbB-4/HER4.
HER4 receptor binding
The process in which the branching structure of the submandibular gland is generated and organized.
submandibular gland branching morphogenesis
submandibular gland ductal branching
Binding to protein phosphatase 5.
protein phosphatase T binding
A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-TNNGNAA-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities.
C/EBP homodimer complex
C/EBP transcription factor complex
C/EBPalpha complex
C/EBPalpha homodimer complex
C/EBPbeta complex
C/EBPbeta homodimer complex
Binding to a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria.
4Fe-3S cluster binding
The process of binding or confining manganese ions such that they are separated from other components of a biological system.
manganese ion retention
manganese ion sequestering
manganese ion sequestration
manganese ion storage
retention of manganese ion
sequestration of manganese ion
storage of manganese ion
A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways.
calprotectin heterodimer
A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4).
S100A8 homodimer
A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility.
S100A9 homodimer
A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes.
Nkx-2.5 homodimer complex
NKX.2-5 homodimer complex
NKX2.5 complex
NKX2E homodimer complex
A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10).
(A2.p11)2 complex
(p11)2.(AnxA2)2 complex
Annexin A2 tetramer
Annexin A2-p11 complex
AnxA2.p11 complex
AnxA2:S100A10 heterotetramer
A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway.
PCSK9.LDLR complex
PCSK9/LDL-R complex
PCSK9:EGF-A complex
PCSK9:low-density lipoprotein receptor complex
A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and annexin A2 (AnxA2).
PCSK9-Annexin A2 complex
PCSK9.AnxA2 complex
PCSK9:ANXA2 complex
The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane of the ER. Such vesicles include COPI-coated transport vesicles involved in retrograde transport.
endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with ER membrane
ER-Golgi intermediate compartment derived vesicle fusion with ER membrane
The lipid bilayer surrounding any of the thin, flattened compartments that form the cis portion of the Golgi complex.
cis-Golgi cisterna membrane
Golgi apparatus cis cisterna membrane
The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex.
Golgi apparatus medial cisterna membrane
medial-Golgi cisterna membrane
The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex.
trans-Golgi cisterna membrane
A protein complex that promotes the biogenesis of mitochondrial F1Fo-ATP synthase by facilitating assembly of the peripheral stalk. Loss of INAC function causes dissociation of the F1-domain from the membrane-integral Fo-portion.
INAC complex
inner membrane assembly complex
mitochondrion inner membrane assembly complex
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a melanocyte-stimulating hormone stimulus. The binding of any one of three melanocyte-stimulating hormones causes dispersal of melanosomes in melanophores of poikilothermic vertebrates.
response to MSH
A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand.
CSF1:C-FMS complex
M-CSF:C-FMS complex
M-CSF:CSF1R complex
M-CSF:FMS complex
macrophage colony-stimulating factor:receptor complex
The joining of the lipid bilayer membrane around an endoplasmic reticulum-derived vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPII-coated transport vesicles involved in anterograde transport.
ER-derived vesicle fusion with ER-Golgi intermediate compartment membrane
ER-derived vesicle fusion with ERGIC membrane
The joining of the lipid bilayer membrane around a Golgi vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPI-coated transport vesicles involved in retrograde transport.
Golgi vesicle fusion with ER-Golgi intermediate compartment membrane
Golgi vesicle fusion with ERGIC membrane
The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPII-coated transport vesicles involved in anterograde transport.
endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with cis-Golgi cisterna membrane
ER-Golgi intermediate compartment derived vesicle fusion with cis-Golgi cisterna membrane
ER-Golgi intermediate compartment derived vesicle fusion with Golgi cis cisterna membrane
ERGIC-derived vesicle fusion with cis-Golgi cisterna membrane
ERGIC-derived vesicle fusion with Golgi cis cisterna membrane
The joining of the lipid bilayer membrane around a Golgi medial cisterna-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport.
Golgi apparatus medial cisterna-derived vesicle fusion with Golgi apparatus cis cisterna membrane
medial-Golgi cisterna-derived vesicle fusion with cis-Golgi cisterna membrane
The joining of the lipid bilayer membrane around a cis-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Vesicles are involved in anterograde transport.
cis-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane
The joining of the lipid bilayer membrane around a trans-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport.
trans-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane
A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7.
USH2 quaternary protein complex
A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C).
MAD1 homodimer
A homodimeric mismatch repair complex involved in binding to and correcting insertion/deletion mutations.
MutS mismatch repair complex
Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex.
CTNNB1-CTNNBIP1 complex
A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC).
Baculoviral IAP repeat-containing protein 5 complex
survivin homodimer complex
Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone.
HPGT
Binding to an mRNA molecule coding sequence (CDS).
mRNA coding region binding
mRNA coding sequence binding
One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections.
C1 tubule
One of two microtubules present in the axonemal central pair. It is distinguishable from the C1 axonemal microtubule (also called C1 tubule) by the presence of differing protein components of the projections.
C2 tubule
A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding.
death-associated protein kinase 1 - calmodulin complex
Cytoplasm situated in close proximity to a nuclear pore complex.
associated with the nuclear pore
A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes.
galectin-1 complex
galectin-2 complex
Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity.
TMD receptor activity
trehalose 6,6\'-dimycolate receptor activity
A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex.
MAD1-MAD2 complex
A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.
p97-p47 complex
A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils.
Titin-Tcap complex
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus.
manganese-induced ER stress response
response to manganese-induced ER stress
response to Mn-induced ER stress
The removal of tubulin heterodimers from one or both ends of a microtubule that is part of the mitotic spindle.
mitotic spindle microtubule depolymerisation
The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins.
protein binding, bridging involved in substrate recognition for ubiquitination
ubiquitin ligase substrate adaptor
ubiquitin ligase-substrate adaptor activity
UFM1 ligase-substrate adaptor activity
Binds to and increases the activity of a ubiquitin ligase.
mitotic anaphase-promoting complex activator activity