NothingMuch/GO-Terms huggingface dataset:
The entry of a symbiont into a host cell, following endocytosis, via permeabilization of the endosomal membrane by membrane penetration protein(s) of the symbiont. This process mediates the entry of some non-enveloped virus into eukaryotic cells. In some cases, viral membrane-penetration protein requires to be activated to display its membrane penetrating activity. Activation can be due to receptor binding or the acidic pH of the endosomal lumen.
viral entry via permeabilization of endosomal membrane
The entry of a symbiont into the cytoplasm of a host cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. This process mediates the entry of some non-enveloped viruses into prokaryotic cells. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization and permeabilization of the plasma membrane.
viral entry via permeabilization of inner membrane
A process by which a symbiont evades and ends degradation of its DNA when free DNA ends are exposed. DNA ends are exposed during the life cycle of some viruses and these are targeted by host cells to destroy the virus. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases.
DNA end degradation evasion by virus
evasion by virus of DNA end degradation
evasion of DNA end degradation by host
A process by which a symbiont evades the DNA restriction modification system of its host. This process occurs in phages to protein themselves from bacterial restriction enzyme systems. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restriction enzymes while some use unusual bases in their genome to avoid restriction.
evasion by virus of host restriction-modification system
evasion of host restriction-modification system
restriction-modification system evasion by virus
Any process in which localization of a protein is maintained at the growing cell tip.
maintenance of protein location at growing cell tip
Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP.
ATP-dependent ceramide transporter activity
ATPase-coupled ceramide transporter activity
ceramide floppase activity (cytosolic to exoplasmic leaflet)
ceramide-translocating ATPase activity
A protein complex that contains TRIP4 (ASC1) and acts a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. In humans this complex has 4 subunits: TRIP4 + ASCC1-3.
ASC-1 complex
A microtubule bundle that has a constant length, and in which microtubule sliding does not take place.
Q-MT bundle
quiescent cell microtubule bundle
quiescent cell MT bundle
A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae.
MDV
Vesicle-mediated transport of cargo from the mitochondrion to the lysosome, mediated by a mitochondrion-derived vesicle.
mitochondrion to lysosome transport
Vesicle-mediated transport of cargo from the mitochondrion to the peroxisome, mediated by a mitochondrion-derived vesicle.
mitochondrion to peroxisome transport
Catalysis of the reaction: 1-hexan-1-one => 1-hexan-1-one + Cl-.
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one 3(5)-dechlorinase activity
1-hexan-1-one 3(5)-dechlorinase activity
DIF-1 3(5)-dechlorinase activity
DIF-1 dechlorinase activity
differentiation-inducing factor 1 dechlorinase activity
differentiation-inducing factor dechlorinase activity
The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse.
anterograde axonal transport of mRNA RNP complex
The directed movement of a messenger ribonucleoprotein complex along microtubules in axons.
axonal transport of mRNA RNP complex
The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine.
establishment of ER localization to postsynapse
A cation channel activity that is gated by binding of a G-protein beta-gamma dimer.
G-protein gated cation channel activity
Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling.
potassium channel activator activity involved in G-protein coupled receptor signaling pathway
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds activation of a potassium ion channel.
potassium channel activating, G-protein coupled receptor signaling pathway
The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron.
somatodendritic dopamine release
STD DA release
STD dopamine release
A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerization and dissociation of the LAP.
TGF-beta complex
TGF-beta dimer
TGFB complex
TGFB dimer
TGFbeta complex
TGFbeta dimer
A protein complex capable of forming 2Fe-2S clusters in mitochondria. In humans it consists of ISCU, NFS1, LYRM4, NDUFAB1 and FXN.
mitochondrial iron-sulfur cluster assembly complex
mitochondrial ISCU complex
Development of a chimeric sorocarp in which cells of all genotypes have an equal chance of becoming a spore cell.
fully co-operative, chimeric sorocarp development
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
regulation of postsynaptic neurotransmitter receptor endocytosis  syngo_official_label
The vesicular release of serotonin from a presynapse, across a chemical synapse, the subsequent activation of serotonin receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
serotonergic synaptic transmission
The vesicular release of noradrenaline (norepinephrine) a presynapse, across a chemical synapse, the subsequent activation of noradrenaline receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
noradrenergic synaptic transmission
Transynaptic signaling in which the ligand is carried across the synapse by an exosome.
exosome mediated transynaptic signalling
trans-synaptic signalling via exosome
Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis.
regulation of presynaptic dense core vesicle exocytosis  syngo_official_label
Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles.
regulation of neurotransmitter uptake into synaptic vesicle
regulation of synaptic vesicle neurotransmitter loading  syngo_official_label
Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex.
regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling
Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by an endocannabinoid.
regulation of endocannabinoid-mediated retrograde trans-synaptic signaling
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
regulation of synapse adhesion between pre- and post-synapse  syngo_official_label
The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle.
zinc import into synaptic vesicle
Zn2+ import into synaptic vesicle
The region of a caveola that extends into the cytoplasm, excluding the neck (rim). This region is associated with intracellular caveola proteins.
caveola crater
Any process that modulates the potential difference across a presynaptic membrane.
regulation of pre-synaptic membrane potential
Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
ligand gated ion channel activity involved in regulation of presynaptic membrane potential
ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential
ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential
ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential
ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse.
voltage gated ion channel activity involved in regulation of presynaptic membrane potential
voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential
voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential
voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential
voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
Any process that regulates the concentration of calcium in the presynaptic cytosol.
regulation of presynaptic cytosolic calcium levels  syngo_official_label
Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
ion antiporter activity involved in regulation of pre-synaptic membrane potential
ion antiporter activity involved in regulation of presynaptic membrane potential
Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential
ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
presynaptic signaling to nucleus
The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations.
calcium ion binding involved in regulation of presynaptic cytosolic calcium levels  syngo_official_label
presynaptic calcium ion buffering
regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering
The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration.
neuropeptide secretion from presynapse via dense core granule exocytosis
The extracellular region immediately adjacent to to a synapse.
extrasynaptic space  syngo_official_label
Any process that regulates the concentration of calcium in the postsynaptic cytosol.
regulation of postsynaptic cytosolic calcium levels  syngo_official_label
The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations.
calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels  syngo_official_label
postsynaptic calcium ion buffering
regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering
The post-synaptic specialization of a glutamatergic excitatory synapse.
postsynaptic specialization, glutamatergic neuron-to-neuron synapse  syngo_official_label
A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential.
G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.
ion antiporter activity involved in regulation of post-synaptic membrane potential
ion antiporter activity involved in regulation of postsynaptic membrane potential
Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.
ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential
ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential
Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol.
neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels  syngo_official_label
The process in which endocytosed synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles.
synaptic vesicle processing via endosome involved in synaptic vesicle recycling
The cell cycle process in which chromosomes that are laterally attached to one or more mitotic spindle microtubules migrate towards the spindle equator via plus-end-directed movement along the microtubules. This process is part of mitotic metaphase plate congression.
plus-end directed chromosome gliding
Any process that regulates the temporal pattern of a sequence of action potentials in a neuron.
spike train sculpting
The initiating cycle of an action potential. In vertebrate neurons this typically occurs at an axon hillock. Not all initiated axon potentials propagate.
action potential firing
action potential triggering
Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor.
D-2HG-pyruvate transhydrogenase activity
R-2-hydroxyglutarate alpha-pyruvate transhydrogenase activity
Catalysis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+.
UDP-GlcUA decarboxylase activity
Catalysis of the reaction: 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose.
10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase activity
ArnAFT activity
UDP-L-Ara4N formyltransferase activity
Catalysis of the reaction: UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate.
UDP-(beta-L-threo-pentapyranosyl-4\'\'-ulose diphosphate) aminotransferase
UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase
UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase
UDP-Ara4O aminotransferase
UDP-L-Ara4N transaminase
Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate.
Ara4FN transferase activity
undecaprenyl phosphate-L-Ara4FN transferase activity
undecaprenyl-phosphate Ara4FN transferase activity
Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels.
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels  syngo_official_label
The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons.
retrograde axon cargo transport
A process in which a protein is transported to, or maintained in, a location within a presynaptic membrane.
protein localisation in presynaptic membrane
protein localisation to presynaptic membrane
protein localization in presynaptic membrane
Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate.
phosphohistidine phosphatase activity
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel whose activity is modulated in response to mechanical stress. Response to mechanical stress and voltage gating together is different than the sum of individual responses. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
mechanically-modulated voltage-gated sodium channel activity
Catalysis of the reaction:  phosphate + H2O =  + phosphate.
isocitrate dehydrogenase kinase/phosphatase activity
Any process that stops, prevents or reduces the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication.
negative regulation of late replication origin firing
Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O.
oestrogen 16-alpha-hydroxylase activity
Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O.
oestrogen 2-hydroxylase activity
A process in which the nuclear inner or outer membrane is synthesized, aggregates, and bonds together during mitotic nuclear division.
nuclear membrane biogenesis involved in mitotic nuclear division
Catalysis of the reaction: an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)- + 2 H+ + O2 = an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)- + 2 H2O or an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)- + 2 H+ + O2 = an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)- + 2 H2O.
acyl-lipid 8-desaturase
Delta(8)-desaturase
Delta8-sphingolipid desaturase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-glutamate(out) -> ADP + phosphate + L-glutamate(in).
L-glutamate-importing ATPase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in).
ATPase-coupled thiosulfate transmembrane transporter activity
thiosulfate transmembrane-transporting ATPase activity
thiosulphate ABC transporter activity
Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced  = an omega-hydroxy-long-chain fatty acid + H+ + H2O + oxidized . A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
cytochrome P450 fatty acid omega-hydroxylase activity
Catalysis of the reaction: a hydroperoxide + H+ + NADH = an alcohol + H2O + NAD+.
alkylhydroperoxide reductase activity
Catalysis of the reaction: dimethylallyl diphosphate + 2 isopentenyl diphosphate = (2Z,6Z)-farnesyl diphosphate + 2 diphosphate.
neryl-diphosphate:isopentenyl-diphosphate cistransferase activity
Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (-)-endo-alpha-bergamotene + diphosphoric acid.
endo-alpha-bergamontene synthase activity
Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphoric acid.
(+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)
(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene
endo-beta-bergamontene synthase activity
Catalysis of the reaction: H2O + a 1-phosphatidyl-1D-myo-inositol 5-phosphate = an 1-phosphatidyl-1D-myo-inositol + phosphate.
phosphatidylinositol-5-phosphate 5-phosphatase activity
Catalysis of the reaction: (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced  = 3-dehydro-6-deoxoteasterone + H+ + H2O + oxidized . Also converts 3-epi-6-deoxocathasterone to 6-deoxotyphasterol.
(22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity
Catalysis of the reaction: carboxynorspermidine + H2O + NADP+ = H+ + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine. Also converts carboxyspermidine to putrescine.
carboxynorspermidine dehydrogenase I activity
carboxynorspermidine dehydrogenase II activity
Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain (2E)-enoyl-CoA. This reaction is the third (dehydration) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.
very-long-chain 3-hydroxyacyl-CoA dehydratase activity
Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-glucuronate = H+ + cyanidin 3-O-beta-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP.
cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity
Catalysis of the reaction: 5-methyl-phenazine-1-carboxylate + 2 H+ + NADH + O2 = CO2 + H2O + NAD+ + pyocyanin. Also converts phenazine-1-carboxylate into 1-hydroxyphenazine.
pyocyanin hydroxylase activity
Catalysis of the reaction: 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD+ = CO2 + cycloeucalenone + NADH.
4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity
Catalysis of the reaction: ATP + a -N6-D-fructosyl-L-lysine = ADP + H+ + a -N6-(3-O-phospho-D-fructosyl)-L-lysine.
fructosamine-3-kinase activity
Catalysis of the reaction: L-idonate + NAD+ = 5-dehydro-D-gluconate + NADH + H+.
L-idonate 5-dehydrogenase activity (NAD-dependent)
Catalysis of the reaction: dinitrogen oxide + H2O + NAD(P) = 2 nitric oxide + H+ + NAD(P)H.
nitric oxide reductase activity (NAD(P)H-dependent) activity
Catalysis of the reaction: 4 H+ + 15-cis-4,4'-diapophytoene + 4 FAD = 4,4'-diapolycopene + 4 FADH2. This reaction consists of four successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene, 4,4'-diapo-zeta-carotene and 4,4'-diapolycopene as intermediates, and 4,4'-diapolycopene as the end product.
4,4\'-diapo-zeta-carotene desaturase activity
4,4\'-diaponeurosporene desaturase activity
4,4\'-diapophytoene desaturase activity
4,4\'-diapophytofluene desaturase activity
Catalysis of the reaction: 2-trans,-6-trans-farnesol + ATP = 2-trans,-6-trans-farnesyl monophosphate + ADP + H+.
ATP-dependent farnesol kinase activity
Catalysis of the reaction: (2E)-geraniol + ATP = (2E)-geranyl phosphate + ADP + H+.
geraniol kinase activity (ATP-dependent) activity
Catalysis of the reaction: (2E,6E,10E)-geranylgeraniol + ATP = (2E,6E,10E)-geranylgeranyl phosphate + ADP + H+.
ATP:geranylgeraniol phosphotransferase activity
Catalysis of the reaction: NADP+ + reduced coenzyme F420-(gamma-L-Glu)(n) = 2 H+ + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n).
F420-dependent NADP reductase activity
Catalysis of the reaction: choline + NADP+ = betaine aldehyde + NADPH + H+.
choline monooxygenase activity (NADP-dependent)
Catalysis of the reaction: erythromycin C + S-adenosyl-L-methionine = erythromycin A + H+ + S-adenosyl-L-homocysteine. Also converts erythromycin D into erythromycin B.
erythromycin C 3\'\'-o-methyltransferase activity
erythromycin D 3\'\'-o-methyltransferase activity