NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix.
double-stranded DNA-dependent ATP-dependent DNA helicase activity
double-stranded DNA-dependent ATPase activity
dsDNA-dependent ATP-dependent DNA helicase activity
dsDNA-dependent ATPase activity
Binding to a member of the bone morphogenetic protein (BMP) family.
bone morphogenetic protein binding
Binding to 3-sulfino-L-alanine (cysteine sulfinate).
cysteine sulfinate binding
A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits.
CATSPER channel
CatSper channel complex
Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).
PGH2 9,11-endoperoxidase
PGH2 9-,11-endoperoxide reductase
Catalysis of the reaction: prostaglandin D2 + H+ + NADPH = 11-epi-prostaglandin F2alpha + NADP+.
PGD2 11-ketoreductase
prostaglandin 11-keto reductase
Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+.
NAD dependent 11-hydroxythromboxane B2 dehydrogenase activity
Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA).
prostaglandin H2 degradation activity
Catalysis of the reaction: L-histidyl- + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl- + succinate + CO2.
protein histidyl hydroxylase
protein-L-histidine (3S)-3-hydroxylase
Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2.
hypoxia-inducible factor-asparagine oxygenase activity
peptidyl-asparagine 3-dioxygenase activity
The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
DC homeostasis
A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again.
digestive rumination
Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains.
phosphatidylglycerol acyl-chain remodelling
Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains.
phosphatidylinositol acyl-chain remodelling
Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains.
phosphatidyl-L-serine acyl-chain remodeling
phosphatidylserine acyl-chain remodelling
Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains.
phosphatidylcholine acyl-chain remodelling
Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains.
phosphatidylethanolamine acyl-chain remodelling
Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains.
triacylglycerol acyl-chain remodeling
triglyceride acyl-chain remodelling
Remodeling the acyl chains of diacylglycerol, through sequential deacylation and re-acylation reactions, to generate diacylglycerol containing different types of fatty acid acyl chains.
diacylglycerol acyl-chain remodelling
diglyceride acyl-chain remodeling
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
inner dynein arm complex
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
outer dynein arm complex
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
ODA assembly
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
IDA assembly
The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation.
MSH secretion
The attachment of a cell to an underlying abiotic (non-living) substrate via adhesion molecules.
cell-abiotic surface adhesion
The growth of colonies in filamentous chains of cells as a result of an increase in temperature.
invasive growth in response to elevated temperature
invasive growth in response to high temperature
invasive growth in response to temperature stimulus
Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O.
sBMO
soluble butane monooxygenase
A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes.
chondroclast maturation
A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase.
protein localisation to linear element
The chemical reactions and pathways resulting in the breakdown of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans.
asperthecin breakdown
asperthecin catabolism
asperthecin degradation
The lipid bilayer surrounding an early phagosome.
early phagocytic vesicle membrane
The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans.
yeast to hyphal transition
Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+.
abietadienal dehydrogenase
Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O.
abietadiene hydroxylase
Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O.
indolin-2-one,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)
Catalysis of the reaction: 3-hydroxyindolin-2-one + O2 + reduced  = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H+ + H2O + oxidized .
3-hydroxyindolin-2-one,NAD(P)H:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming)
The chemical reactions and pathways resulting in the formation of zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol).
zymosterol anabolism
zymosterol biosynthesis
zymosterol formation
zymosterol synthesis
Any process which produces dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate) without de novo synthesis.
deoxythymidine monophosphate biosynthesis via salvage pathway
dTMP biosynthesis via salvage pathway
Catalysis of the reaction: androsta-1,4-diene-3,17-dione + 2 H+ + O2 + 2 reduced - = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized -.
3-ketosteroid 9alpha-hydroxylase activity
KshAB activity
Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O.
ent-cassadiene C11alpha-hydroxylase activity
The chemical reactions and pathways resulting in the breakdown of a histone protein by individual cells.
histone protein catabolic process
Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 reduced  = 9beta-pimara-7,15-dien-19-oate + 4 H+ + 4 H2O + 3 oxidized .
9-beta-stemod-13(17)-ene oxidase activity
Catalysis of the reaction: dGTP + H2O = dGMP + H+ + diphosphate.
2\'-deoxyguanosine 5\'-triphosphate diphosphohydrolase
dGTP pyrophosphatase activity
Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate.
dTTP pyrophosphatase activity
Catalysis of the reaction: GTP + H2O = GMP + H+ + diphosphate.
GTP diphosphohydrolase (diphosphate-forming); guanosine 5\'-triphosphate pyrophosphohydrolase
GTP diphosphohydrolase activity
GTP pyrophosphatase activity
Catalysis of the reaction: ITP + H2O = IMP + H+ + diphosphate.
inosine-5\'-triphosphate pyrophosphohydrolase activity
ITP pyrophosphatase activity
Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate.
uridine triphosphate pyrophosphohydrolase activity
Catalysis of the reaction: XTP + H2O = XMP + H+ + diphosphate.
hypoxanthine/xanthine dNTP pyrophosphatase
XTP pyrophosphohydrolase activity
XTP/dITP diphosphatase
XTPase activity
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine.
cellular response to adenine deprivation
A special chromosome region located towards one end of a chromosome that contains dispersed copies of short, repetitive DNA sequences and functions as a cis-acting element essential for presynaptic homologous chromosome pairing and chromosome-nuclear envelope attachment.
homolog recognition region
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of vitamin B1 (also called thiamin and thiamine).
cellular response to thiamin starvation
cellular response to vitamin B1 deprivation
A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane.
protein targeting to INM
protein targeting to nuclear inner membrane
Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate.
acyl-glucuronide deglucuronidation activity
The region between the plasma membrane and the cell wall, as found in organisms such as filamentous fungi.
cell wall-enclosed septal periplasm
The chemical reactions and pathways resulting in the breakdown of glutamate into 4-hydroxybutyrate.
glutamate degradation to 4-hydroxybutyrate
Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+.
NADP-dependent succinate-semialdehyde dehydrogenase activity
succinate semialdehyde:NADP+ oxidoreductase activity
succinic semialdehyde dehydrogenase (NADP+) activity
succinyl semialdehyde dehydrogenase (NADP+) activity
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position.
cellular response to vitamin K3
The directed movement of phytochelatin 2 (PC2) into the vacuole. Phytochelatin 2 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=2, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond.
PC2 import into vacuole
The directed movement of phytochelatin 3 (PC3) into the vacuole. Phytochelatin 3 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=3, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond.
PC3 import into vacuole
The directed movement of phytochelatin 4 (PC4) into the vacuole. Phytochelatin 4 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=4, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond.
PC4 import into vacuole
The directed movement of cadmium ions into the vacuole.
vacuolar cadmium import
The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
multivesicular body biogenesis
MVB biogenesis
MVB formation
The chemical reactions and pathways resulting in the breakdown of raffinose that occur in the presence of oxygen.
aerobic raffinose breakdown
aerobic raffinose catabolism
aerobic raffinose degradation
Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation.
2,2,7-trimethylguanosine cap formation
conversion of m(7)G to m(3)G
hypermethylation of snoRNA cap
hypermethylation of snRNA cap
m(7)G cap hypermethylation
snoRNA capping
snRNA capping
TMG cap formation
A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p.
Cdc48p-Npl4p-Vms1p complex
Vms1-Cdc48-Npl4 complex
Vms1p-Cdc48p-Npl4p complex
The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.
swimming behaviour
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.
response to MPD
response to MPH
response to ritalin
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas.
response to 2\',2\'-difluorodeoxycytidine
response to 2\'-deoxy-2\',2\'-difluorocytidine
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus.
response to 5-fluoropyrimidine-2,4(1H,3H)-dione
response to fluorouracil
The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof.
SAGA complex formation
A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1.
linear eisosome
The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA.
DNA annealing
RPA-dependent DNA rewinding
single-stranded DNA bubble rewinding
Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.
Fanconi pathway
recombination-dependent interstrand cross-link repair
Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination.
recombination-independent ICL repair
recombination-independent interstrand cross-link repair
Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere.
cellular protein localization to M-band
protein localization to M disc
protein localization to M line
protein localization to mesophragma
An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule.
annealing helicase activity
ATP-dependent DNA annealing activity
DNA rewinding activity
nucleoside-triphosphatase activity involved in DNA annealing
Catalysis of the reaction: H2O + N,N'-diacetylchitobiose = acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine.
chitin oligosaccharide amidohydrolase activity
chitin oligosaccharide deacetylase activity
chitobiose amidohydrolase activity
Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.
p85 binding
PI3K regulatory subunit binding
Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
p110 binding
PI3K catalytic subunit binding
Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis.
unlinkase activity
uridylylpolynucleotide-(5\' P->O)- tyrosine phosphodiesterase activity
VPg unlinkase activity
Y-pUpN PDE activity
Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus.
M-factor mating pheromone receptor activity
M-factor receptor activity
Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus.
P-factor mating pheromone receptor activity
P-factor receptor activity
The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone.
pancreatic ghrelin secretion
The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas.
PP secretion
The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-1 (VEGFR-1) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
FLT1 signaling pathway
VEGFR-1 signaling pathway
VEGFR1 signaling pathway
The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-2 (VEGFR-2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
FLK-1 signaling pathway
KDR signaling pathway
VEGFR-2 signaling pathway
VEGFR2 signaling pathway
The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-3 (VEGFR-3) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
FLT4 signaling pathway
VEGFR-3 signaling pathway
VEGFR3 signaling pathway
Combining with placental growth factor (PlGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
placental growth factor-activated receptor activity
PlGF receptor activity
PlGF-activated receptor activity
Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells.
intestinal crypt stem cell homeostasis
The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream.
lymphocyte adhesion to HEV cell
lymphocyte adhesion to high endothelial venule
The process of hardening a chitin-based cuticle by mineral incorporation. For example, the cuticle of crustaceans is hardened by the incorporation of calcium carbonate.
chitin-based cuticle hardening by biomineralisation
The process of hardening of a chitin-based cuticle by protein cross-linking, and the incorporation of phenolic precursors. This mechanism of cuticle hardening occurs in insects and is usually accompanied by darkening of the cuticle.
chitin-based cuticle sclerotization by protein cross-linking and cuticle tanning
The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other.
cell-cell adhesion involved in galactose-specific flocculation
The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other.
cell-cell adhesion involved in mannose-specific flocculation
Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate.
cDPGS activity
CPGS activity
The formation of a D-alanyl ester of lipoteichoic acid by transfer of D-Ala onto a membrane-associated lipoteichoic acid (LTA).
D-alanyl lipoteichoic acid formation
D-alanyl LTA formation
LTA D-alanylation
The elimination of potassium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine.
renal K(+) excretion
renal K+ elimination
renal potassium ion excretion
The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum.
fruiting body stalk morphogenesis
The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers.
cone phototransduction termination
cone response recovery