NothingMuch/GO-Terms huggingface dataset:
The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a membrane in a cell.
membrane macromolecule anabolism
membrane macromolecule biosynthesis
membrane macromolecule formation
membrane macromolecule synthesis
Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds.
detoxification of arsenic
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus.
cellular response to diacylated bacterial lipoprotein
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus.
cellular response to triacylated bacterial lipoprotein
A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
IgG antibody
IgG1 antibody
IgG2 antibody
IgG2a antibody
IgG2b antibody
IgG2c antibody
IgG3 antibody
IgG4 antibody
An IgG immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
membrane-bound IgG
membrane-bound IgG1
membrane-bound IgG2
membrane-bound IgG2a
membrane-bound IgG2b
membrane-bound IgG2c
membrane-bound IgG3
membrane-bound IgG4
surface IgG
surface IgG1
surface IgG2
surface IgG2a
surface IgG2b
surface IgG2c
surface IgG3
surface IgG4
A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
IgD antibody
An IgD immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
membrane-bound IgD
surface IgD
A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and bound via a GPI-anchor to the plasma membrane of B cells.
GPI-anchored IgD
A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
IgE antibody
An IgE immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
membrane-bound IgE
surface IgE
An IgA immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
membrane-bound IgA
membrane-bound IgA1
membrane-bound IgA2
surface IgA
surface IgA1
surface IgA2
A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
monomeric IgA antibody
monomeric IgA1 antibody
monomeric IgA2 antibody
A dimeric form of secretory IgA immunoglobulin complex.
secretory dimeric IgA antibody
secretory dimeric IgA1 antibody
An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
membrane-bound IgM
surface IgM
A circulating form of IgM consisting of a pentamer of IgM core units with a single J chain polypeptide.
pentameric IgM antibody
A circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide.
hexameric IgM antibody
A protein complex composed of two identical immunoglobulin heavy chains of the IgZ isotype and two identical immunoglobulin light chains, held together by disulfide bonds. The IgZ isotype is also known as the IgT isotype in certain species of fish.
IgT antibody
IgT immunoglobulin complex
IgZ antibody
A protein complex composed of two identical immunoglobulin heavy chains of the IgNAR isotype held together by disulfide bonds and lacking immunoglobulin light chains.
HCab
Ig NAR immunoglobulin complex
IgNAR antibody
IgNAR immunoglobulin complex
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane.
nuclear outer membrane organisation
nuclear outer membrane organization and biogenesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane.
nuclear inner membrane organisation
nuclear inner membrane organization and biogenesis
The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain.
mycolate biosynthetic process
mycolic acid anabolism
mycolic acid biosynthesis
mycolic acid formation
mycolic acid synthesis
The aggregation, arrangement and bonding together of a set of components, including arabinogalactan mycolate and trehalose dimycolate, to form the mycolate layer of the Actinobacterium-type cell wall. The mycolate layer is physically attached to the peptidoglycan layer.
mycolate cell wall layer biogenesis
The aggregation, arrangement and bonding together of a set of components, including (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate and diphthioceranate, to form the DIM/DIP layer of the Actinobacterium-type cell wall.
DIM cell wall layer assembly
DIM/DIP cell wall layer biogenesis
PDIM cell wall layer assembly
Catalysis of the reaction: a long-chain fatty aldehyde + H+ + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP+.
aldehyde decarbonylase activity
decarbonylase activity
The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section.
endoplasmic reticulum cisternal network formation
ER cisternal network assembly
ER cisternal network formation
The organization process that preserves the endoplasmic reticulum (ER) cisternal network in a stable functional or structural state. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section.
ER cisternal network maintenance
The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section.
endoplasmic reticulum tubular network assembly
ER tubular network assembly
ER tubular network formation
The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section.
ER tubular network maintenance
Binding to chemokine (C-C motif) ligand 5.
CCL5 binding
RANTES binding
Regulated upon Activation, Normal T-cell Expressed, and Secreted binding
The chemical reactions and pathways resulting in the formation of bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species.
bacillithiol anabolism
bacillithiol biosynthesis
bacillithiol formation
bacillithiol synthesis
Any process that stops, prevents or reduces the rate or extent of podosome assembly.
down regulation of podosome assembly
down-regulation of podosome assembly
downregulation of podosome assembly
inhibition of podosome assembly
Any process that activates or increases the rate or extent of podosome assembly.
activation of podosome assembly
stimulation of podosome assembly
up regulation of podosome assembly
up-regulation of podosome assembly
upregulation of podosome assembly
Binding to a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm.
IDL binding
intermediate-density lipoprotein binding
A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.
protein insertion of tail-anchored membrane proteins into ER membrane
tail-anchored membrane protein insertion into endoplasmic reticulum membrane
type II transmembrane protein insertion into ER membrane
A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation.
MMS19-MIP18-XPD complex
A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A.
Bag6 complex
BAG6-UBL4A-TRC35 complex
BAT3-TRC35-UBL4A complex
A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p.
deubiquitinating module
deubiquitination module
SAGA DUBm complex
Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses.
N box binding
N-box promoter binding
The process in which chylomicron remnant-associated apolipoprotein E is internalized by endocytosis, localized to recycling endosomes and then secreted in association with a high-density lipoprotein particle.
APOE recycling
The process in which a intermediate-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
IDL clearance
The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that regulates the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms.
mating pheromone secretion involved in regulation of conjugation
mating-type pheromone secretion involved in conjugation
peptide pheromone export involved in regulation of conjugation
The controlled release of a nectar by a cell or a tissue. Nectar is a fluid secreted by many angiosperms to promote pollination by providing a reward to pollinators. Nectar may also deter certain organisms from visiting or play other biological roles. Nectar is a complex solution that may include the following types of compounds: sugars, amino acids, organic acids, alkaloids, flavonoids, glycosides, vitamins, phenolics, metal ions, oils, free fatty acids, and proteins.
nectar production
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
cellular response to adrenaline stimulus
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.
cellular response to noradrenaline stimulus
Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands.
regulation of adrenergic receptor signaling pathway
regulation of adrenergic receptor signalling pathway
A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
activation of phospholipase C activity by adrenergic receptor signaling pathway
activation of phospholipase C activity by adrenergic receptor signalling pathway
adrenergic receptor, phospholipase C activating pathway
The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand and leading to the activation of a MAP kinase cascade.
activation of MAP kinase activity by adrenergic receptor signaling pathway
activation of MAP kinase activity by adrenergic receptor signalling pathway
activation of MAPK activity by adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signalling pathway
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser.
X-Pro-Lys N-terminal methyltransferase
Binding to the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug.
(+/-)2-(4-iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine binding
1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane binding
4-iodo-2,5-dimethoxyphenylisopropylamine binding
Binding to bicarbonate ions (CHO3-).
CHO3- ion binding binding
hydrogencarbonate binding
A cell activation process that occurs in thrombocytes and consists of a series of progressive, overlapping events including shape change, adhesiveness, and aggregation, which, when carried through to completion, lead to the formation of a stable hemostatic plug. Thrombocytes are nucleated cells found in non-mammalian vertebrates and are involved in hemostasis. They are the functional equivalent of the non-nucleated platelets found in mammals.
blood coagulation, thrombocyte activation
Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins.
context dependent regulatory domain binding
An extracellular membrane-bounded vesicle that contains prominin proteins (in mouse Prom1/CD33 or Prom2) and are found in body fluids including ventricular fluid, saliva, urine and seminal fluid. In the ventricular fluid of the developing mouse brain two major classes of these particles have been observed (P2 particles of 500-1000 nm and P4 particles of 50-80 nm) which likely originate from microvilli, primary cilia and/or the midbody of neuroepithelial cells. The physiological role is not known.
prominin-containing extracellular membrane vesicle
A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature.
G quadruplex DNA formation
G quartet DNA formation
G-quartet DNA formation
The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
C-C motif chemokine 22 production
CCL-22 production
CCL22 production
The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
TSLP production
The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid.
vitamin A import
vitamin A uptake
A process that modulates flagellum-dependent motility in bacteria by modulating the speed or direction of rotation of a rotary flagellar motor, mediated by interactions between the braking protein.
regulation of bacterial-type flagellar cell motility by regulation of motor speed
regulation of bacterial-type flagellum cell motility by regulation of motor speed
regulation of flagellar cell motility by regulation of motor speed
A DNA replication termination process that is initiated by protein binding to a binding site on the same chromosome, but remote from the termination site, via DNA looping or chromosome kissing.
cis acting DNA replication termination
B cell apoptotic process that occurs upon engagement of either the B cell receptor or CD40. Engagement of either receptor, but not both, leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death.
activated B cell apoptosis
activation-induced B cell apoptosis
activation-induced B-cell apoptosis
activation-induced cell death of B cells
activation-induced cell death of B lymphocytes
activation-induced cell death of B-cells
activation-induced cell death of B-lymphocytes
AICD
antigen-driven apoptosis
Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
oxidized flavin adenine dinucleotide binding
oxidized flavine-adenine dinucleotide binding
Binding to the reduced form, FADH2, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
reduced flavin adenine dinucleotide binding
reduced flavine-adenine dinucleotide binding
An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.
elastic fibre
elastin fiber
The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
C-C motif chemokine 11 production
CCL-11 production
CCL11 production
eotaxin production
eotaxin-1 production
The spindle pole body that exists in a cell prior to spindle pole body duplication. An old spindle pole body segregates to the daughter cell upon mitosis, and lacks active proteins involved in signaling exit from mitosis.
old SPB
The spindle pole body that is formed by spindle pole body duplication, and to which proteins involved in mitotic exit signaling (for example, the septation initiation network in fission yeast) localize.
new SPB
Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+.
LPS core heptosyltransferase activity
Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium.
bacterial-type flagellar swimming motility
bacterial-type flagellum-mediated cell swimming
Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
bacterial-type flagellar swarming motility
bacterial-type flagellum-mediated cell swarming
Cell motility in which contractile cytoskeletal elements alter cell shape, resulting in the smooth movement of a cell through a liquid medium.
cytoskeleton-mediated swimming motility
A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified).
EGO complex
EGO-GSE complex
GSE complex
GTPase-containing complex for Gap1p sorting in the endosome
MAPKSP1/ROBLD3/C11orf59 complex
Rag GEF
Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain.
beta-transducin repeat domain binding
WD domain binding
Any process in which a protein is maintained in a specific location at the spindle pole body, and is prevented from moving elsewhere.
maintenance of protein location at spindle pole body
maintenance of protein location in spindle pole body
The directed movement of glutathione into the vacuole across the vacuolar membrane.
glutathione transport into vacuole
A developmental process that results in the discharge of ascospores from the ascus. Ascospore release may be active or passive.
ascospore liberation
The process in which the identity of a kidney is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
maintenance of kidney anlage identity
The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment.
pronephric glomus development
Any process that mediates the transfer of information from one cell to another that modulates the rate, frequency, or extent of pre-tubular aggregate formation. Pre-tubular aggregate formation is the cell adhesion process in which mesenchymal cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney.
regulation of pre-tubular aggregate formation by cell-cell signalling