NothingMuch/GO-Terms huggingface dataset:
The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.
pacemaker cell differentiation
The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node.
SA node cell differentiation
SAN cell differentiation
sinus node cell differentiation
The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node.
AV node cell differentiation
The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
cardiomyocyte cell fate commitment
heart muscle cell fate commitment
The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.
pacemaker cell development
The commitment of cells to pacemaker cell fates and their capacity to differentiate into pacemaker cells. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.
pacemaker cell fate commitment
The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart.
heart neuron differentiation
The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers.
heart vascular smooth muscle cell differentiation
The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state.
heart vascular smooth muscle cell development
The commitment of cells to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell.
heart vascular smooth muscle cell fate commitment
Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II.
regulation of ribosomal protein gene transcription from RNA polymerase II promoter
A process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs).
regulation of gene silencing by microRNA
regulation of gene silencing by miRNA
A process that decreases the rate, frequency, or extent of gene silencing by a microRNA (miRNA).
negative regulation of gene silencing by microRNA
negative regulation of gene silencing by miRNA
Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes.
regulation of gene silencing by RNA
Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes.
negative regulation of gene silencing by ncRNA
negative regulation of gene silencing by RNA
The orderly movement of a cardioblast toward the midline to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
cardiac progenitor cell midline migration
cardioblast midline convergence
The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.
cardiac blood vessel development
cardiac vasculature development
coronary blood vessel development
heart blood vessel development
heart vasculature development
The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood.
cardiac blood vessel morphogenesis
cardiac vasculature morphogenesis
coronary blood vessel morphogenesis
heart blood vessel morphogenesis
heart vasculature morphogenesis
Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels.
angiogenesis involved in cardiac vascular morphogenesis
angiogenesis involved in heart vascular morphogenesis
coronary blood vessel angiogenesis
coronary vasculature angiogenesis
The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes.
coronary vasculogenesis
vasculogenesis involved in coronary blood vessel morphogenesis
The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission.
lipid tubulation
Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ.
cell-cell signalling involved in kidney development
Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate.
kidney pattern formation
kidney pattern specification
pattern formation involved in kidney development
The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.
hepatobiliary system development
The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine.
bile duct development
CBD development
EHBD development
extrahepatic bile duct development
Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
regulation of mRNA decay
Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
positive regulation of mRNA decay
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
cellular membrane organisation
cellular membrane organization
membrane organisation
membrane organization and biogenesis
single-organism membrane organization
The membrane organization process that joins two lipid bilayers to form a single membrane.
cellular membrane fusion
single-organism membrane fusion
The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
cardiac muscle cell hypertrophy
cardiomyocyte growth
heart muscle cell growth
The series of molecular signals initiated by binding of peptidoglycan to a receptor and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides.
Imd signaling pathway
Imd signalling pathway
immune deficiency pathway
immune deficiency signaling pathway
PGRP signaling pathway
Any process that modulates the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway.
regulation of peptidoglycan recognition protein signalling pathway
Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response.
positive regulation of myeloid cell cytokine production involved in immune response
The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium.
gastric neuroendocrine cell differentiation
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells.
dense core granule organisation
Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
type I terminal button
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
regulation of insulin secretion in response to glucose
The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
breast epithelium development
Any process that modulates the rate, frequency, or extent of rDNA heterochromatin formation.
regulation of chromatin silencing at rDNA
regulation of ribosomal DNA heterochromatin assembly
A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle.
clathrin sculpted GABA transport vesicle
clathrin sculpted gamma-aminobutyric acid transport vesicle
The process in which the anatomical structures of the mesonephros are generated and organized.
Wolffian body morphogenesis
Any developmental process that results in the creation of defined areas or spaces within the mesonephros to which cells respond and eventually are instructed to differentiate.
mesonephros pattern formation
mesonephros pattern specification
The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros.
mesonephric glomerular visceral epithelial cell differentiation
A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros.
mesonephric mesenchyme to epithelial transition
The developmental process pertaining to the initial formation of the mesonephros.
mesonephros formation
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the mesonephros as it progresses from its formation to the mature state.
mesonephros interstitial cell differentiation
The process whose specific outcome is the progression of the mesonephric connecting tubule over time, from its formation to the mature structure. The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros.
mesonephric collecting tubule development
mesonephric connecting duct development
Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros.
regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis
regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis
The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.
retinal vasculature development
The process in which the vasculature of the retina is generated and organized.
retinal vasculature morphogenesis
The series of molecular signals initiated by a ligand the binding to its receptor on the surface of a cell, which contributes to the progression of the heart over time.
cell surface receptor linked signaling pathway involved in heart development
cell surface receptor linked signalling pathway involved in heart development
The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time.
Notch signalling involved in heart development
The movement of an epithelial cell with respect to other epithelial cells that contributes to the shaping of the Malpighian tubule.
cell migration involved in Malpighian tubule morphogenesis
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time.
non-canonical Wnt receptor signaling pathway involved in heart development
non-canonical Wnt receptor signalling pathway involved in heart development
non-canonical Wnt-activated signaling pathway involved in heart development
Any process that increases the activity of triglyceride lipase.
positive regulation of TAG activity
Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.
determination of cardiac left/right asymmetry
The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol.
Golgi calcium ion export
Enables the transfer of L-arginine from one side of a membrane to the other.
arginine permease activity
arginine porter activity
arginine transmembrane transporter activity
arginine-importing ATPase activity
ATP-dependent L-arginine transmembrane transporter activity
ATPase-coupled L-arginine transmembrane transporter activity
histidine/arginine/lysine/ornithine porter activity
L-arginine transporter activity
L-arginine-importing ATPase activity
A cellular process that results in the breakdown of a cilium.
cilium resorption
The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure.
ganglia development
gangliogenesis
The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.
cranial ganglia development
The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.
trigeminal ganglia development
The process in which the anatomical structures of ganglion are generated and organized.
ganglia morphogenesis
A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state.
ganglia maturation
The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts.
ganglia formation
The process that contributes to creating the structural organization of a ganglion. This process pertains to the physical shaping of a rudimentary structure.
ganglia structural organization
The process in which the anatomical structure of a trigeminal ganglion is generated and organized.
trigeminal ganglia morphogenesis
A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state.
cranial ganglia maturation
The process in which the anatomical structure of a cranial ganglion is generated and organized.
cranial ganglia morphogenesis
The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts.
cranial ganglia formation
The process that contributes to creating the structural organization of a cranial ganglion. This process pertains to the physical shaping of a rudimentary structure.
cranial ganglia structural organization
A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.
actin filament cable organization
A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel.
generation of L-type calcium current
The controlled release of orexin from a cell or a tissue.
hypocretin secretion
The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation.
microRNA gene transcription
miRNA gene transcription
pri-miRNA transcription by RNA polymerase II
pri-miRNA transcription from RNA polymerase II promoter
primary miRNA gene transcription
The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH.
glycolysis through fructose-6-phosphate
Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
RNA polymerase II activating transcription factor binding
RNA polymerase II repressing transcription factor binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
RNA polymerase II sequence-specific DNA-binding transcription factor binding
RNA polymerase II transcription factor binding
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
E3
ER-associated E3 ligase
protein ubiquitination activity
ubiquitin ligase activity
The specialized chromatin located in the centromeric core region or the entire centromeric region in organisms with point centromeres, which is enriched for CENP-A-containing nucleosomes. This chromatin forms a 3-dimensional structure which provides a platform for kinetochore assembly and microtubule attachment.
centromeric core domain chromatin
centromeric core region chromatin
chromatin containing CENP-A
nuclear CENP-A containing chromatin
Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another molecule, usually another protein, via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue.
E2
small conjugating protein conjugating enzyme activity
Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate.
E3
small conjugating protein ligase activity
Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate.
E3
Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential.
stimulus-independent neurotransmitter secretion
The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate.
gluconate pathway
The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded.
CASA
chaperone-assisted selective autophagy
CMA
The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.
autophagy of the endoplasmic reticulum
autophagy of the ER
endoplasmic reticulum autophagy
endoplasmic reticulum degradation
ER autophagy
ER degradation
ER-phagy
The chemical reactions and pathways resulting in the breakdown of glucose, with the production of pyruvate.
glucose catabolism to pyruvate
Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.
adenosylcobalamin-dependent ribonucleotide reductase activity
aerobic non-heme iron-dependent ribonucleotide reductase activity
anaerobic iron-sulfur-dependent ribonucleotide reductase activity
class I ribonucleotide reductase activity
class II ribonucleoside-diphosphate reductase activity
class II ribonucleotide reductase activity
class III ribonucleotide reductase activity
nucleoside diphosphate reductase activity
purine/pyrimidine nucleoside diphosphate reduction
ribonucleoside 5\'-diphosphate reductase activity
ribonucleotide diphosphate reductase activity
ribonucleotide reductase activity
RNR
Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide.
peptide-lysine-N-acetylase activity
protein acetylase activity
protein acetyltransferase activity
protein-lysine-N-acetylase activity
The selective autophagy process in which a mitochondrion is degraded by macroautophagy in a process initiated by mitochondrial depolarization (mtDepo) followed by Parkin binding, and ubiquitination of outer membrane proteins, to remove potentially harm-inducing dysfunctional/damaged mitochondria.
Park2-mediated mitophagy in response to mitochondrial depolarization
parkin-mediated mitophagy in response to mitochondrial depolarization
PRKN-mediated mitophagy in response to mitochondrial depolarization
The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
stress-activated AMP-activated protein kinase signaling cascade
Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA.
DNA exit from the cohesin ring
Any process that reduces the pH of the Golgi lumen, measured by the concentration of the hydrogen ion.
Golgi apparatus lumen acidification
The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase.
mitotic spindle elongation during mitotic prophase
mitotic spindle elongation during prophase
mitotic spindle elongation during prophase and prometaphase