NothingMuch/GO-Terms huggingface dataset:
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.
down regulation of brain-derived neurotrophic factor receptor signaling pathway
down-regulation of brain-derived neurotrophic factor receptor signaling pathway
downregulation of brain-derived neurotrophic factor receptor signaling pathway
inhibition of brain-derived neurotrophic factor receptor signaling pathway
negative regulation of BDNF receptor signaling pathway
negative regulation of BDNF receptor signalling pathway
negative regulation of brain-derived neurotrophic factor receptor signalling pathway
Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.
activation of brain-derived neurotrophic factor receptor signaling pathway
positive regulation of BDNF receptor signaling pathway
positive regulation of BDNF receptor signalling pathway
positive regulation of brain-derived neurotrophic factor receptor signalling pathway
stimulation of brain-derived neurotrophic factor receptor signaling pathway
up regulation of brain-derived neurotrophic factor receptor signaling pathway
up-regulation of brain-derived neurotrophic factor receptor signaling pathway
upregulation of brain-derived neurotrophic factor receptor signaling pathway
Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.
regulation of BDNF receptor activity
regulation of brain-derived neurotrophic factor receptor activity
A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch.
ribosome-mediated transcriptional attenuation
A positive regulation of gene expression mechanism that allows RNA polymerase to continue transcription beyond a termination site, thus allowing expression of downstream genes under specific conditions.
transcriptional readthrough
A signal transduction process that contributes to a cell size control checkpoint during the G1/S transition of the cell cycle.
G1 cell size control checkpoint
G1 cell size control checkpoint signalling
mitotic cell cycle G1/S transition size control checkpoint
mitotic G1 cell size control checkpoint
signal transduction involved in G1 cell size control checkpoint
signal transduction involved in mitotic cell cycle G1/S transition size control checkpoint
A signal transduction process that contributes to a cell size control checkpoint prior to the G2/M transition of mitosis.
G2 cell size control checkpoint
G2/M transition size control checkpoint
mitotic cell cycle G2/M transition size control checkpoint
mitotic G2 cell size control checkpoint
signal transduction involved in G2 cell size control checkpoint
signal transduction involved in G2/M transition size control checkpoint
signal transduction involved in mitotic cell cycle G2/M transition size control checkpoint
A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
intra-S DNA damage checkpoint
mitotic intra-S DNA damage checkpoint
S-phase checkpoint
signal transduction involved in intra-S DNA damage checkpoint
A signaling process that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected.
mitotic cell cycle spindle orientation checkpoint
mitotic spindle orientation checkpoint
signal transduction involved in mitotic cell cycle spindle orientation checkpoint
SOC
spindle position checkpoint
SPOC
A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase D (PLD) and a subsequent increase in the intracellular concentration of phosphatidic acid (PA).
activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway
G-protein signalling, phospholipase D activating pathway
phospholipase D-activating G-protein coupled receptor signaling pathway
Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
activation of IP3 receptor activity
positive regulation of inositol-1,4,5-trisphosphate receptor activity
positive regulation of IP3 receptor activity
stimulation of IP3 receptor activity
up regulation of IP3 receptor activity
up-regulation of IP3 receptor activity
upregulation of IP3 receptor activity
A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
5\'-AMP-activated protein kinase complex
ADP-activated protein kinase complex
AMP-activated protein kinase complex
AMPK complex
Snf1 kinase complex
Snf1 serine/threonine protein kinase complex
SNF1/AMPK protein kinase complex
The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazopurine-7-butanoic acid, 4,9-dihydro- alpha-- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.
yW biosynthesis
yW biosynthetic process
The cell cycle process in which the sister centromeres and kinetochores of one chromosome are fused and orientated so the chromosomes attach to microtubules that emanate from the same spindle pole. This process ensures that homologous l chromosomes are segregated at anaphase of meiosis I.
homologous chromosome orientation during meiosis
homologous chromosome orientation during meiosis I
Any process that stops, prevents, or reduces the rate or extent of fever generation.
down regulation of fever
down-regulation of fever
downregulation of fever
inhibition of fever
negative regulation of pyrexia
Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.
ubiquitin ligase binding
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.
down regulation of synaptic vesicle fusion to presynaptic active zone membrane
down regulation of synaptic vesicle fusion to presynaptic membrane
down-regulation of synaptic vesicle fusion to presynaptic active zone membrane
down-regulation of synaptic vesicle fusion to presynaptic membrane
downregulation of synaptic vesicle fusion to presynaptic active zone membrane
downregulation of synaptic vesicle fusion to presynaptic membrane
inhibition of synaptic vesicle fusion to presynaptic membrane
negative regulation of synaptic vesicle fusion to pre-synaptic active zone membrane
negative regulation of synaptic vesicle fusion to pre-synaptic membrane
negative regulation of synaptic vesicle fusion to presynaptic membrane
The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
neurotrophin-induced neuronal synaptic plasticity
Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
down regulation of myelination
down-regulation of myelination
downregulation of myelination
inhibition of myelination
Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
activation of myelination
stimulation of myelination
up regulation of myelination
up-regulation of myelination
upregulation of myelination
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
negative regulation of protein stability
protein destabilisation
Any process that stops, prevents, or reduces the rate or extent of heat dissipation.
down regulation of heat dissipation
down-regulation of heat dissipation
downregulation of heat dissipation
inhibition of heat dissipation
Any process that activates or increases the rate or extent of heat dissipation.
activation of heat dissipation
stimulation of heat dissipation
up regulation of heat dissipation
up-regulation of heat dissipation
upregulation of heat dissipation
Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
activation of lipopolysaccharide-mediated signaling pathway
positive regulation of lipopolysaccharide-mediated signalling pathway
positive regulation of LPS-mediated signaling pathway
stimulation of lipopolysaccharide-mediated signaling pathway
up regulation of lipopolysaccharide-mediated signaling pathway
up-regulation of lipopolysaccharide-mediated signaling pathway
upregulation of lipopolysaccharide-mediated signaling pathway
A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments.
H band
H disc
The pigmented membrane of a plasma membrane-derived thylakoid.
plasma membrane thylakoid membrane
The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange.
G-beta/G-gamma complex
heterotrimeric G-protein GTPase, beta-subunit
Binding to a G-protein beta subunit.
G-beta protein subunit binding
Binding to a G-protein gamma subunit.
G-gamma protein subunit binding
Binding to an A1 adenosine receptor.
A1 adenosine receptor ligand
Binding to an A2A adenosine receptor.
A2A adenosine receptor ligand
Binding to an A2B adenosine receptor.
A2B adenosine receptor ligand
Binding to an A3 adenosine receptor.
A3 adenosine receptor ligand
Binding to an alpha-1A adrenergic receptor.
alpha-1A adrenergic receptor ligand
Binding to an alpha-1B adrenergic receptor.
alpha-1B adrenergic receptor ligand
Binding to an alpha-1D adrenergic receptor.
alpha-1D adrenergic receptor ligand
Binding to an alpha-2A adrenergic receptor.
alpha-2A adrenergic receptor ligand
Binding to an alpha-2B adrenergic receptor.
alpha-2B adrenergic receptor ligand
Binding to an alpha-2C adrenergic receptor.
alpha-2C adrenergic receptor ligand
Binding to a beta-1 adrenergic receptor.
beta-1 adrenergic receptor ligand
Binding to a beta-2 adrenergic receptor.
beta-2 adrenergic receptor ligand
Binding to a beta-3 adrenergic receptor.
beta-3 adrenergic receptor ligand
Binding to an adrenomedullin receptor.
adrenomedullin receptor ligand
Binding to a type 1 angiotensin receptor.
AT1 receptor binding
type 1 angiotensin receptor ligand
Binding to a type 2 angiotensin receptor.
AT2 receptor binding
type 2 angiotensin receptor ligand
Binding to an apelin receptor.
apelin receptor ligand
APJ receptor binding
Binding to a subtype 3 bombesin receptor.
subtype 3 bombesin receptor ligand
Binding to an endothelin A receptor.
endothelin A receptor ligand
endothelin-1 receptor binding
Binding to an endothelin B receptor.
endothelin B receptor ligand
Binding to a gastrin-releasing peptide receptor.
gastrin-releasing peptide receptor ligand
GRP receptor binding
Binding to a neuromedin B receptor.
neuromedin B receptor ligand
Binding to a B1 bradykinin receptor.
B1 bradykinin receptor ligand
Binding to a B2 bradykinin receptor.
B2 bradykinin receptor ligand
Binding to a C5L2 anaphylatoxin chemotactic receptor.
C5L2 anaphylatoxin chemotactic receptor ligand
Binding to a calcitonin receptor.
calcitonin receptor ligand
Binding to a type 1 cannabinoid receptor.
type 1 cannabinoid receptor ligand
Binding to a type 2 cannabinoid receptor.
type 2 cannabinoid receptor ligand
Binding to a CXCR4 chemokine receptor.
CXCR4 chemokine receptor ligand
stromal cell-derived factor 1 receptor binding
Binding to a CXCR5 chemokine receptor.
CXCR5 chemokine receptor ligand
type 1 Burkitt\'s lymphoma receptor binding
Binding to a CXCR6 chemokine receptor.
bonzo receptor binding
CXCR6 chemokine receptor ligand
STRL33 receptor binding
Binding to a CCR1 chemokine receptor.
CCR1 chemokine receptor ligand
macrophage inflammatory protein-1 alpha receptor binding
Binding to a CCR2 chemokine receptor.
CCR2 chemokine receptor ligand
monocyte chemoattractant protein 1 receptor binding
Binding to a CCR3 chemokine receptor.
CCR3 chemokine receptor ligand
eosinophil eotaxin receptor binding
Binding to a CCR4 chemokine receptor.
CCR4 chemokine receptor ligand
Binding to a CCR5 chemokine receptor.
CCR5 chemokine receptor ligand
Binding to a CCR6 chemokine receptor.
CCR6 chemokine receptor ligand
LARC receptor binding
Binding to a CCR7 chemokine receptor.
CCR7 chemokine receptor ligand
MIP-3 beta receptor binding
type 1 EBV-induced G-protein coupled receptor binding
Binding to a CCR8 chemokine receptor.
CCR8 chemokine receptor ligand
Binding to a CCR9 chemokine receptor.
CCR9 chemokine receptor ligand
Binding to a CCR10 chemokine receptor.
CCR10 chemokine receptor ligand
Binding to a CCR11 chemokine receptor.
CCR11 chemokine receptor ligand
Binding to a CX3C chemokine receptor.
CX3C chemokine receptor ligand
fractalkine receptor binding
Binding to a XCR1 chemokine receptor.
lymphotactin receptor binding
XCR1 chemokine receptor ligand
Binding to a type A cholecystokinin receptor.
type A cholecystokinin receptor ligand
Binding to a type B gastrin/cholecystokinin receptor.
type B gastrin/cholecystokinin receptor ligand
Binding to a type 1 cysteinyl leukotriene receptor.
type 1 cysteinyl leukotriene receptor ligand
Binding to a type 2 cysteinyl leukotriene receptor.
type 2 cysteinyl leukotriene receptor ligand
Binding to a D1 dopamine receptor.
D1 dopamine receptor ligand
D1A dopamine receptor binding
Binding to a D2 dopamine receptor.
D2 dopamine receptor ligand
Binding to a D3 dopamine receptor.
D3 dopamine receptor ligand
Binding to a D4 dopamine receptor.
D4 dopamine receptor ligand
Binding to a D5 dopamine receptor.
D1B dopamine receptor binding
D5 dopamine receptor ligand
Binding to an Edg-1 sphingosine 1-phosphate receptor.
Edg-1 sphingosine 1-phosphate receptor ligand
Binding to an Edg-2 lysophosphatidic acid receptor.
Edg-2 lysophosphatidic acid receptor ligand
LPA1 receptor binding
Binding to an Edg-3 sphingosine 1-phosphate receptor.
Edg-3 sphingosine 1-phosphate receptor ligand
Binding to an Edg-4 lysophosphatidic acid receptor.
Edg-4 lysophosphatidic acid receptor ligand
LPA2 receptor binding
Binding to an Edg-5 sphingosine 1-phosphate receptor.
Edg-5 sphingosine 1-phosphate receptor ligand
Binding to an Edg-6 sphingosine 1-phosphate receptor.
Edg-6 sphingosine 1-phosphate receptor ligand
Binding to an Edg-7 lysophosphatidic acid receptor.
Edg-7 lysophosphatidic acid receptor ligand
LPA3 receptor binding
Binding to a fMet-Leu-Phe receptor.
fMet-Leu-Phe receptor ligand
N-formyl peptide receptor binding
Binding to a follicle-stimulating hormone receptor.
follicle stimulating hormone receptor binding
follicle stimulating hormone receptor ligand
FSH receptor binding
Binding to a type 1 galanin receptor.
type 1 galanin receptor ligand
Binding to a type 2 galanin receptor.
type 2 galanin receptor ligand
Binding to a type 3 galanin receptor.
type 3 galanin receptor ligand
Binding to a gastric inhibitory polypeptide receptor.
gastric inhibitory polypeptide receptor ligand
Binding to a ghrelin receptor.
ghrelin receptor ligand
type 1 growth hormone secretagogue GH-releasing peptide receptor binding
Binding to a glucagon receptor.
glucagon receptor ligand
Binding to a growth hormone-releasing hormone receptor.
growth hormone-releasing hormone receptor ligand
Binding to a type 1 orexin receptor.
OX1 orexin receptor binding
type 1 hypocretin receptor binding
type 1 hypocretin receptor ligand
Binding to a type 2 orexin receptor.
OX2 orexin receptor binding
type 2 hypocretin receptor binding
type 2 hypocretin receptor ligand
Binding to a kisspeptin receptor.
G-protein coupled receptor 54 binding
hOT7T175 receptor binding
hypogonadotropin-1 receptor binding
KiSS-1 receptor binding
kisspeptin receptor ligand
metastin receptor binding
Binding to a leukotriene receptor.
leukotriene receptor ligand
Binding to a lutropin-choriogonadotropic hormone receptor.
lutropin-choriogonadotropic hormone receptor ligand
Binding to a type 1 melanin-concentrating hormone receptor.
type 1 melanin-concentrating hormone receptor ligand
Binding to a type 2 melanin-concentrating hormone receptor.
type 2 melanin-concentrating hormone receptor ligand
Binding to a corticotropin hormone receptor.
ACTH receptor binding
adrenocorticotropic hormone receptor ligand
adrenocorticotropin hormone receptor binding
adrenocorticotropin receptor binding
corticotropin receptor binding
Binding to a type 3 melanocortin receptor.
type 3 melanocortin receptor ligand
Binding to a type 4 melanocortin receptor.
type 4 melanocortin receptor ligand
Binding to a type 5 melanocortin receptor.
type 5 melanocortin receptor ligand
Binding to a type 1A melatonin receptor.
type 1A melatonin receptor ligand
Binding to a type 1B melatonin receptor.
type 1B melatonin receptor ligand
Binding to a H9 melatonin receptor.
H9 melatonin receptor ligand
Binding to a motilin receptor.
motilin receptor ligand
Binding to a G protein-coupled acetylcholine receptor.
G-protein coupled acetylcholine receptor binding
M1 muscarinic acetylcholine receptor binding
M1 muscarinic acetylcholine receptor ligand
M2 muscarinic acetylcholine receptor binding
M2 muscarinic acetylcholine receptor ligand
M3 muscarinic acetylcholine receptor binding
M3 muscarinic acetylcholine receptor ligand
M4 muscarinic acetylcholine receptor binding
M4 muscarinic acetylcholine receptor ligand
M5 muscarinic acetylcholine receptor binding
M5 muscarinic acetylcholine receptor ligand
muscarinic acetylcholine receptor binding
muscarinic acetylcholine receptor ligand
Binding to a type 1 metabotropic GABA receptor.
type 1 metabotropic GABA receptor ligand
Binding to a type 2 metabotropic GABA receptor.
type 2 metabotropic GABA receptor ligand
Binding to a type 1 metabotropic glutamate receptor.
type 1 metabotropic glutamate receptor ligand
Binding to a type 2 metabotropic glutamate receptor.
type 2 metabotropic glutamate receptor ligand
Binding to a type 3 metabotropic glutamate receptor.
type 3 metabotropic glutamate receptor ligand
Binding to a type 4 metabotropic glutamate receptor.
type 4 metabotropic glutamate receptor ligand
Binding to a type 5 metabotropic glutamate receptor.
type 5 metabotropic glutamate receptor ligand
Binding to a type 6 metabotropic glutamate receptor.
type 6 metabotropic glutamate receptor ligand
Binding to a type 7 metabotropic glutamate receptor.
type 7 metabotropic glutamate receptor ligand
Binding to a type 8 metabotropic glutamate receptor.
type 8 metabotropic glutamate receptor ligand
Binding to a H1 histamine receptor.
H1 histamine receptor ligand
Binding to a H2 histamine receptor.
H2 histamine receptor ligand
Binding to a H3 histamine receptor.
H3 histamine receptor ligand
Binding to a H4 histamine receptor.
H4 histamine receptor ligand
Binding to a P2Y1 nucleotide receptor.
P2Y1 nucleotide receptor ligand
Binding to a P2Y2 nucleotide receptor.
P2Y2 nucleotide receptor ligand
Binding to a P2Y4 nucleotide receptor.
P2Y4 nucleotide receptor ligand
Binding to a P2Y5 nucleotide receptor.
P2Y5 nucleotide receptor ligand
Binding to a P2Y6 nucleotide receptor.
P2Y6 nucleotide receptor ligand
Binding to a P2Y8 nucleotide receptor.
P2Y8 nucleotide receptor ligand
Binding to a P2Y9 nucleotide receptor.
P2Y9 nucleotide receptor ligand
Binding to a P2Y10 nucleotide receptor.
P2Y10 nucleotide receptor ligand
Binding to a P2Y11 nucleotide receptor.
P2Y11 nucleotide receptor ligand
Binding to a type 1B serotonin receptor.
5-hydroxytryptamine 1B receptor binding
type 1B serotonin receptor ligand
Binding to a type 1D serotonin receptor.
5-hydroxytryptamine 1D receptor binding
type 1D serotonin receptor ligand
Binding to a type 1E serotonin receptor.
5-hydroxytryptamine 1E receptor binding
type 1E serotonin receptor ligand
Binding to a type 1F serotonin receptor.
5-hydroxytryptamine 1F receptor binding
type 1F serotonin receptor ligand
Binding to a type 2A serotonin receptor.
5-hydroxytryptamine 2A receptor binding
type 2A serotonin receptor ligand
Binding to a type 2B serotonin receptor.
5-hydroxytryptamine 2B receptor binding
type 2B serotonin receptor ligand
Binding to a type 2C serotonin receptor.
5-hydroxytryptamine 2C receptor binding
type 2C serotonin receptor ligand
Binding to a type 4 serotonin receptor.
5-hydroxytryptamine 4 receptor binding
type 4 serotonin receptor ligand
Binding to a type 5A serotonin receptor.
5-hydroxytryptamine 5A receptor binding
type 5A serotonin receptor ligand
Binding to a type 5B serotonin receptor.
5-hydroxytryptamine 5B receptor binding
type 5B serotonin receptor ligand
Binding to a type 6 serotonin receptor.
5-hydroxytryptamine 6 receptor binding
type 6 serotonin receptor ligand
Binding to a type 7 serotonin receptor.
5-hydroxytryptamine 7 receptor binding
type 7 serotonin receptor ligand
Binding to a substance P receptor.
neurokinin-1 receptor binding
substance P receptor ligand
Binding to a neuromedin K receptor.
neurokinin-B receptor binding
neuromedin K receptor ligand
Binding to a substance K receptor.
neurokinin-A receptor binding
substance K receptor ligand
Binding to a type 1 neuromedin U receptor.
type 1 neuromedin U receptor ligand
Binding to a type 2 neuromedin U receptor.
type 2 neuromedin U receptor ligand
Binding to a type 1 neuropeptide Y receptor.
type 1 neuropeptide Y receptor ligand
Binding to a type 2 neuropeptide Y receptor.
type 2 neuropeptide Y receptor ligand
Binding to a type 4 neuropeptide Y receptor.
pancreatic polypeptide receptor binding
type 4 neuropeptide Y receptor ligand
Binding to a type 5 neuropeptide Y receptor.
type 5 neuropeptide Y receptor ligand
Binding to a type 1 neurotensin receptor.
type 1 neurotensin receptor ligand
Binding to an olfactory receptor.
olfactory receptor ligand
Binding to a delta-type opioid receptor.
delta-type opioid receptor ligand
enkephalin receptor binding
Binding to a kappa-type opioid receptor.
dynorphin receptor binding
kappa-type opioid receptor ligand
Binding to a mu-type opioid receptor.
morphine receptor binding
mu-type opioid receptor ligand
Binding to a nociceptin receptor.
nociceptin receptor ligand
Binding to an orexigenic neuropeptide QRFP receptor.
orexigenic neuropeptide QRFP receptor ligand
Binding to an oxytocin receptor.
oxytocin receptor ligand
Binding to a type 1 parathyroid hormone receptor.
type 1 parathyroid hormone receptor ligand
Binding to a pituitary adenylate cyclase-activating polypeptide receptor.
PACAP receptor binding
pituitary adenylate cyclase activating peptide receptor binding
pituitary adenylate cyclase-activating peptide receptor ligand
Binding to a platelet activating factor receptor.
platelet activating factor receptor ligand
The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans.
telomere 3\'-end processing
telomere end processing