NothingMuch/GO-Terms huggingface dataset:
Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
change of myofibril size
Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
change of myofibril number
The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation.
transition between fast and slow fibre
transition fast-slow fiber
transition fast-slow fibre
The series of events by which an injury stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation.
detection of injury involved in regulation of muscle plasticity
The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation.
transition between slow and fast fibre
transition slow-fast fiber
transition slow-fast fibre
The chemical reactions and pathways involving tetrahydrocorphins, tetrapyrroles that combine the structural elements of both porphyrins and corrins.
tetrahydrocorphin metabolism
The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan.
heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism
heparan sulfate proteoglycan chain elongation
heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis
heparan sulfate proteoglycan formation, polysaccharide chain formation
heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis
heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis
heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process
heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization.
heparan sulfate proteoglycan anabolism, enzymatic modification
heparan sulfate proteoglycan formation, enzymatic modification
heparan sulfate proteoglycan synthesis, enzymatic modification
heparan sulphate proteoglycan biosynthesis, enzymatic modification
heparan sulphate proteoglycan biosynthetic process, enzymatic modification
heparin proteoglycan biosynthetic process, enzymatic modification
Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(n) = adenosine 3',5'-bisphosphate + 2 H+ + N-sulfo-alpha-D-glucosaminyl-(n).
3\'-phosphoadenylyl-sulfate:-glucosamine N-sulfotransferase activity
3\'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity
3\'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity
3\'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity
-glucosamine N-sulphotransferase activity
desulfoheparin sulfotransferase activity
glucosaminyl N-deacetylase/N-sulfotransferase activity
heparan sulfate 2-N-sulfotransferase activity
heparan sulfate N-deacetylase/N-sulfotransferase activity
heparan sulfate N-sulfotransferase activity
heparin N-deacetylase/N-sulfotransferase activity
heparin N-deacetylase/N-sulphotransferase activity
heparin N-sulfotransferase activity
heparin-glucosamine N-sulfotransferase activity
heparitin N-sulfotransferase activity
heparitin N-sulphotransferase activity
heparitin sulfotransferase activity
N-desulfoheparin sulfotransferase activity
N-heparan sulfate sulfotransferase activity
N-HSST activity
PAPS:DSH sulfotransferase activity
PAPS:N-desulfoheparin sulfotransferase activity
Catalysis of the reaction: 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl- + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl- + H+ + UDP.
glucuronosyltransferase I activity
UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity
UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity
uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity
Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide.
acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity
acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity
heparin-alpha-glucosaminide N-acetyltransferase activity
Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.
-sulfate lyase activity
heparin-sulfate eliminase activity
heparin-sulphate lyase activity
heparitin-sulfate lyase activity
heparitinase I
heparitinase II
Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate.
chondro-2-sulfatase activity
glucuronate-2-sulphatase activity
glucurono-2-sulfatase activity
polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
coreceptor, insoluble ligand activity
coreceptor, soluble ligand activity
Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.
adrenodoxin reductase activity
adrenodoxin-type ferredoxin reductase activity
NADPH:adrenodoxin oxidoreductase activity
Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide.
NADPH:trypanothione oxidoreductase activity
trypanothione reductase activity
trypanothione-disulfide reductase (NADP) activity
trypanothione-disulfide reductase activity
trypanothione-disulphide reductase activity
trypanothione:NADP+ oxidoreductase activity
Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin.
ferric leghemoglobin reductase activity
NAD(P)H:ferrileghemoglobin oxidoreductase activity
Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+.
dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity
DPNH-rubredoxin reductase activity
NADH--rubredoxin oxidoreductase activity
NADH--rubredoxin reductase activity
NADH:rubredoxin oxidoreductase activity
NADH:rubredoxin reductase activity
reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity
rubredoxin--NAD reductase activity
rubredoxin--nicotinamide adenine dinucleotide reductase activity
rubredoxin:NAD+ oxidoreductase activity
Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2.
cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)
NADPH:ferricytochrome-c2 oxidoreductase activity
reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)
Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O.
methane hydroxylase activity
methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors.
beta3 adrenoceptor
Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity.
cholecystokinin-B receptor activity
A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
thrombin receptor activity
thrombin receptor activity, G-protein coupled
Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate.
arginine-glycine amidinotransferase activity
arginine-glycine transamidinase activity
glycine transamidinase activity
L-arginine:glycine amidinotransferase activity
Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine.
inosamine-P amidinotransferase activity
inosamine-phosphate amidinotransferase activity
L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity
L-arginine:inosamine phosphate amidinotransferase activity
L-arginine:inosamine-P-amidinotransferase activity
Enables the transfer of aluminum (Al) ions from one side of a membrane to the other.
aluminium ion transporter activity
aluminium resistance permease activity
aluminum resistance permease activity
Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high affinity copper ion transmembrane transporter activity
high affinity copper transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.
low affinity iron ion transmembrane transporter activity
low affinity iron transporter activity
Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high affinity ferric uptake transmembrane transporter activity
Enables the transfer of lead (Pb) ions from one side of a membrane to the other.
zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out).
phosphoenolpyruvate/phosphate translocator
PPT
Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose.
L-idonate/D-gluconate:hydrogen symporter activity
Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds.
monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
prostaglandin/thromboxane transporter activity
Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6.
hexuronide transmembrane transporter activity
Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals.
uric acid transmembrane transporter activity
Enables the transbilayer of capsular-polysaccharides (Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III)) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of ECA. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi.
capsular polysaccharide transmembrane transporter activity
capsule polysaccharide transporter activity
undecaprenol-pyrophosphate O-antigen flippase activity
Enables the transfer of an arabitol from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms.
arabinitol transporter activity
Enables the transfer of L-cystine from one side of a membrane to the other.
cystine/diaminopimelate porter activity
L-cystine transporter activity
Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid.
isoleucine/valine:sodium symporter activity
L-isoleucine transporter activity
leucine/isoleucine/valine porter activity
leucine/valine/isoleucine permease activity
Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid.
L-leucine transporter activity
leucine/isoleucine/valine porter activity
leucine/valine/isoleucine permease activity
Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid.
L-phenylalanine permease activity
L-phenylalanine transporter activity
Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid.
glycine betaine/proline porter activity
L-proline permease activity
L-proline transporter activity
proline/glycine/betaine:hydrogen/sodium symporter activity
Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid.
L-serine permease activity
L-serine transporter activity
serine transporter activity
threonine/serine:sodium symporter activity
Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.
LPS transmembrane transporter activity
Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme.
biopterin transporter activity
Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.
biotin transporter activity
vitamin B7 transporter activity
vitamin H transporter activity
Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2--4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species.
L-ascorbate transporter activity
vitamin C transporter activity
Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form.
FAD carrier activity
FAD transporter activity
flavin adenine dinucleotide carrier activity
flavin adenine dinucleotide transmembrane transporter activity
flavin-adenine dinucleotide carrier activity
flavin-adenine dinucleotide transmembrane transporter activity
Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other.
5-formyltetrahydrofolate transporter activity
Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.
pantothenate transporter activity
vitamin B5 transmembrane transporter activity
Enables the energy-independent facilitated diffusion of water through a transmembrane aqueous pore or channel.
aquaporin
Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane.
organellar voltage gated chloride channel activity
organellar voltage-dependent chloride channel activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose(out) = D-glucose(in).
galactose, glucose uniporter activity
glucose uniporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in).
cation/sialate symporter activity
cation:sialate symporter activity
sialate transporter activity
sialate/cation symporter activity
sialate:cation symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out).
cycloheximide:hydrogen antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out).
benomyl:hydrogen antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out).
monoamine:hydrogen antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out).
polyamine:hydrogen antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out).
fluconazole:hydrogen antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out).
aminotriazole:hydrogen antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in).
phosphate ion carrier activity
phosphate:hydrogen symporter activity
Enables the transfer of glutamine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high affinity glutamine permease activity
high affinity glutamine transmembrane transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement.
peptide:hydrogen symporter activity
Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.
high affinity oligopeptide transporter activity
high-affinity oligopeptide transporter activity
Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force.
zinc efflux permease activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in).
ferrioxamine uptake transmembrane transporter activity
siderochrome-iron (ferrioxamine) uptake transporter
siderophore-iron uptake transmembrane transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in).
ferric enterobactin:hydrogen symporter activity
ferric-enterobactin:proton symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in).
ferric triacetylfusarinine C:hydrogen symporter activity
Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
methotrexate transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in).
acetate:hydrogen symporter activity
hydrogen:acetate symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.
low affinity sodium:dicarboxylate cotransporter activity
low affinity sodium:dicarboxylate symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high affinity sodium:dicarboxylate cotransporter activity
high affinity sodium:dicarboxylate symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + phosphate(in) = dicarboxylate(in) +  phosphate(out).
dicarboxylate:inorganic phosphate antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in).
L-malic acid permease
L-malic acid:proton symporter activity
malate permease
malate:hydrogen symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out).
2-oxoglutarate/malate carrier protein
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).
calcium:hydrogen antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in).
neutral, cationic amino acid:sodium:chloride symporter activity
Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations.
high affinity sulfate permease activity
high affinity sulfate transmembrane transporter activity
high affinity sulphate permease activity