NothingMuch/GO-Terms huggingface dataset:
Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein.
mu-opioid receptor activity
Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin.
kappa-opioid receptor activity
Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
estrogen receptor activity
G-protein coupled estrogen receptor activity
Binding to tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family.
CD254 binding
ODF binding
OPGL binding
osteoclast differentiation factor binding
osteoprotegerin ligand binding
RANKL binding
receptor activator of nuclear factor kappa-B ligand binding
TNF-related activation-induced cytokine binding
TRANCE binding
tumor necrosis factor (ligand) superfamily member 11 binding
tumor necrosis factor ligand superfamily member 11 binding
tumor necrosis factor superfamily member 11 binding
A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits.
IkappaB kinase alpha homodimer
IkappaB kinase-alpha homodimer
IKKalpha homodimer
IKKalpha homodimeric complex
IKKalpha-IKKalpha protein complex
Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
collagen RTK activity
discoidin domain receptor
The series of molecular signals initiated by collagen binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
collagen-activated RTK signaling pathway
collagen-activated tyrosine kinase receptor signalling pathway
DDR signaling pathway
discoidin domain receptor signaling pathway
Binding to a vascular endothelial growth factor.
VEGF binding
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to an alpha-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
vascular endothelial growth factor-activated platelet-derived growth factor receptor-alpha signaling pathway
VEGF-A/PDGFRalpha signaling
VEGF-activated PDGFRalpha signalling pathway
VEGF-activated platelet-derived growth factor receptor-alpha signalling pathway
VEGF/PDGFRalpha signaling pathway
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a beta-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
vascular endothelial growth factor-activated platelet-derived growth factor receptor-beta signaling pathway
VEGF-A/PDGFRbeta signaling
VEGF-activated PDGFRbeta signalling pathway
VEGF-activated platelet-derived growth factor receptor-beta signalling pathway
VEGF/PDGFRbeta signaling pathway
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another.
positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signalling pathway
positive regulation of cell migration by VEGF/PDGFR signaling pathway
VEGF/PDGFR-induced cell migration
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation.
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signalling pathway
positive regulation of cell proliferation by VEGF/PDGFR signaling pathway
VEGF-A-induced cell proliferation
An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors.
Fc epsilon RI-dependent mast cell activation
Fc epsilon RI-mediated mast cell activation
positive regulation of mast cell activation by Fc-epsilon receptor signalling pathway
Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor.
extracellular sequestering of BMP
extracellular sequestering of bone morphogenetic protein
Binding to a nodal protein in the extracellular region, and inhibiting nodal signaling by preventing nodal from binding to its cell surface receptor.
binding to and sequestering nodal
extracellular regulation of nodal
nodal antagonist activity
A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell.
ActRIIB.ALK4.EGF-CFC complex
Binding to a transforming growth factor-beta (TGFbeta) protein in the extracellular region, and inhibiting TGFbeta signaling by preventing TGFbeta from binding to its cell surface receptor.
extracellular sequestering of TGFbeta
extracellular sequestering of transforming growth factor-beta
Binding to choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit.
chorionic gonadotrophin binding
chorionic gonadotropin binding
The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food.
inhibition of appetite by leptin signaling
negative regulation of appetite by leptin-mediated signalling pathway
reduction of appetite by leptin-mediated signaling
suppression of appetite by leptin-mediated signaling pathway
The series of molecular signals initiated by interleukin-7 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-7-mediated signaling pathway
interleukin-7-mediated signalling pathway
The series of molecular signals initiated by interleukin-8 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-8-mediated signaling pathway
interleukin-8-mediated signalling pathway
The series of molecular signals initiated by interleukin-9 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-9-mediated signaling pathway
interleukin-9-mediated signalling pathway
The series of molecular signals initiated by interleukin-21 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-21-mediated signaling pathway
interleukin-21-mediated signalling pathway
Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
CCL19 receptor activity
The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
CCL19-activated CCR7 signalling pathway
The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
CCL21-activated CCR7 signalling pathway
Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
CCL21 receptor activity
Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
CCL5 receptor activity
RANTES receptor activity
small inducible cytokine A5 receptor activity
The series of molecular signals initiated by a ligand binding of a heterodimeric TLR1:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
TLR2:TLR1 signaling pathway
toll-like receptor TLR1:TLR2 signalling pathway
The series of molecular signals initiated by a ligand binding of a heterodimeric TLR6:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
TLR2:TLR6 signaling pathway
toll-like receptor TLR6:TLR2 signalling pathway
Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
NRG receptor activity
NRG1 receptor activity
NRG2 receptor activity
The series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission.
ERBB2-ERBB3 signalling pathway
HER2-HER3 signaling pathway
The series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR.
EGFR-HER2 signaling pathway
ERBB2-EGFR signalling pathway
The series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4.
ERBB2-ERBB4 signalling pathway
HER2-HER4 signaling pathway
The series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors ERBB3 and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription.
ERBB3-ERBB4 signalling pathway
HER3-HER4 signaling pathway
The series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription.
ERBB1-ERBB4 signaling pathway
ERBB4-EGFR signalling pathway
HER1-HER4 signaling pathway
The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
ERBB4 homodimeric signaling pathway
ERBB4-ERBB4 signalling pathway
HER4-HER4 signaling pathway
A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1).
EGFR-ERBB4 complex
ERBB4:EGFR heterodimer
A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission.
ERBB3-ERBB4 complex
ERBB4:ERBB3 heterodimer
A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4).
ERBB4 homodimer
A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR.
EGF:EGFR:ERBB2 complex
EGFR:ERBB2 heterodimer
A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3.
EGFR:ERBB2 heterodimer
NRG1/2:ERBB3:ERBB2
A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4.
ERBB4:ERBB2 heterodimer
NRGs/EGFLs:ERBB4:ERBB2
Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
CXCL12 receptor activity
CXCR4
CXCR7
SDF-1 receptor activity
stromal cell-derived factor-1 receptor activity
Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
CCL2 receptor activity
The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
CCL2/CCR2 signaling pathway
The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
CCL2/CCR4 signaling pathway
The series of molecular signals initiated by the binding of interleukin-11 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-11-mediated signaling pathway
interleukin-11-mediated signalling pathway
The series of molecular signals initiated by interleukin-23 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-23-mediated signaling pathway
interleukin-23-mediated signalling pathway
The series of molecular signals initiated by interleukin-3 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-3-mediated signaling pathway
interleukin-3-mediated signalling pathway
The series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors.
CSF2 signaling pathway
GM-CSF receptor signaling pathway
GM-CSF signaling pathway
granulocyte-macrophage colony-stimulating factor receptor signaling pathway
granulocyte-macrophage colony-stimulating factor signalling pathway
The series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R).
CSF3 signaling pathway
G-CSF receptor signaling pathway
G-CSF signaling pathway
granulocyte colony-stimulating factor receptor signaling pathway
granulocyte colony-stimulating factor signalling pathway
The series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
CXCL12-activated CXCR4 signalling pathway
The series of molecular signals initiated by erythropoietin (EPO) binding to the erythropoietin receptor (EPO-R) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
EPO-R signaling pathway
erythropoietin receptor signaling pathway
The series of molecular signals initiated by thrombopoietin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
THPO signaling pathway
THPO/MPL signaling pathway
thrombopoietin receptor signaling pathway
The series of molecular signals initiated by oncostatin-M (OSM) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways.
oncostatin-M signaling pathway
OSM signaling pathway
A G protein-coupled receptor signaling pathway initiated by somatostatin binding to a somatostatin receptor (SSTR), and ending with the regulation of a downstream cellular process, e.g. transcription.
somatostatin signalling pathway
somatostatin-activated somatostatin receptor signaling pathway
somatostatin-mediated signaling pathway
somatotrophin release inhibiting factor signaling pathway
SRIF signaling pathway
SST signaling pathway
The series of molecular signals initiated by interleukin-33 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-33-mediated signaling pathway
IL33 signaling pathway
interleukin-33 signaling pathway
interleukin-33-mediated signalling pathway
The series of molecular signals initiated by interleukin-17A binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-17A-mediated signaling pathway
IL17A signaling pathway
interleukin-17A signaling pathway
interleukin-17A-mediated signalling pathway
Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels.
negative regulation of SREBP-mediated signaling pathway in presence of oxygen
negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels
Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway in response to a decrease in oxygen levels.
positive regulation of SREBP-mediated signaling pathway in absence of oxygen
positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels
Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor.
death receptor activator activity
A G protein-coupled receptor signaling pathway initiated by a C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor.
complement component C5a-induced signaling pathway
The series of molecular signals initiated by nerve growth factor (NGF) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
nerve growth factor signalling pathway
NGF signaling pathway
Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
cell surface bile acid receptor
G-protein coupled bile acid receptor activity
lithocholic acid receptor activity
membrane bile acid receptor activity
An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to a bile acid receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process.
cell surface bile acid receptor signaling pathway
membrane bile acid receptor signaling pathway
A nuclear receptor-mediated signaling pathway initiated by a bile acid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
BAR signaling pathway
farnesoid X receptor signaling pathway
FXR signaling pathway
intracellular bile acid receptor signaling pathway
nuclear bile acid receptor signaling pathway
A DNA-binding transcription factor activity regulated by binding to a bile acid that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
farnesoid X nuclear receptor activity
farnesoid X receptor activity
lithocholic acid receptor activity
Binding to a member of the neuropilin family.
neuropilin-binding
Nrp binding
Nrp ligand
A G protein-coupled receptor signaling pathway initiated by gastric inhibitory peptide (GIP) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
gastric inhibitory polypeptide receptor signaling pathway
GIP signaling
glucose-dependent insulinotropic polypeptide signaling
A G protein-coupled receptor signaling pathway initiated by thromboxane A2 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
TXA(2) receptor signaling
TXA2 signaling
A G protein-coupled receptor signaling pathway initiated by thyroid-stimulating hormone (thyrotropin) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
thyrotropin signaling pathway
TSH signaling pathway
The series of molecular signals initiated by urokinase plasminogen activator binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
uPA signaling pathway
The series of molecular signals initiated by type III interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far.
interferon lambda signaling pathway
type III interferon signaling pathway
type III interferon-activated signaling pathway
A heterodimeric protein complex that binds a type I interferon and transmits the signal across the membrane into the cell. Consists of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2).
interferon-alpha/beta receptor complex
The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop.
pronephric kidney field specification