NothingMuch/GO-Terms huggingface dataset:
An embryonic stem cell-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or an ortholog thereof. Compared to many other BAF complexes never contains ACTL6B/BAF53B, ARID1B/BAF250B, SMARCA2/BRM, SMARCC2/BAF170 or SMARCD3/BAF60C but contains PHF10/BAF45A, DPF2/BAF45D and possibly one of BCL7A/B/C.
embryonic stem cell-specific BAF complex
embryonic stem cell-specific SWI/SNF complex
The series of molecular signals initiated by interleukin-10 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-10-mediated signaling pathway
interleukin-10-mediated signalling pathway
Enables the transfer of D-glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high-affinity glucose transmembrane transporter activity
The assembly and secretion of a set of components to form an extracellular microvesicule, a membrane-bounded vesicle that ranges in size 100 nm to 1 micron in size) and exits the cell by budding.
extracellular microvesicle assembly
Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family.
COG complex binding
Any apoptotic process that occurs as a result of mitochondrial fragmentation.
apoptosis in response to mitochondrial fragmentation
The directed import of zinc(2+) from the cytosol, across the endoplasmic reticulum membrane, into the endoplasmic reticulum.
zinc ion import across endoplasmic reticulum
zinc ion import into ER
zinc(2+) import across endoplasmic reticulum
zinc(2+) import into endoplasmic reticulum
Host-derived membrane of a pathogen-containing vacuole.
pathogen inclusion membrane
pathogen-containing compartment membrane
The enclosed volume within the sealed membrane of a pathogen-containing vacuole.
lumen of a pathogen-containing vacuole
pathogen inclusion lumen
pathogen-containing compartment lumen
pathogen-containing vacuolar lumen
A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities.
Top3-beta-TDRD3 complex
The series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.
5-HT-gated cation-selective signaling pathway
5-HT-gated cation-selective signalling pathway
5-hydroxytryptamine-gated cation-selective signaling pathway
5-hydroxytryptamine-gated cation-selective signalling pathway
serotonin-gated cation-selective signalling pathway
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential.
intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential.
intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential
A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus.
perforant pathway to DG granule cell synapse
A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes. In mammals, the core subunits of the complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP and the components of the SCF ubiquitin ligase, SKP1, and FBXL10.
BCL6 corepressor (BCOR) complex
BCOR/BCORL1 complex
non-canonical BCOR-PRC1.1 complex
non-canonical PRC1-BCOR complex
PRC1.1 complex
A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes.
endoplasmic reticulum-plasma membrane contact junction
EPCS
ER-plasma membrane contact site
ER-PM contact site
A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1.
mitochondrial intermembrane space bridging complex
mitofilin complex
Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate.
L-glutamate--lipid II transaminase activity
undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl pentapeptide amidotransferase (glutamine-hydrolyzing) activity
A contact site between the endoplasmic reticulum membrane and the endosome membrane.
ER-endosome membrane contact site
The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity.
host-selective toxin
innate receptor ligand activity
necrotrophic effector
Binding and sequestering PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response.
pathogen-associated molecular pattern receptor decoy activity
pattern recognition receptor decoy activity
A process in which a symbiont inhibits or disrupts the normal execution of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
negative regulation by symbiont of host autophagy
suppression of host autophagy
Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane.
intermembrane lipopolysaccharide transfer activity
intermembrane lipopolysaccharide transporter activity
intermembrane LPS transporter activity
lipopolysaccharide carrier activity
A process in which a lipopolysaccharide is transported to the cell outer membrane.
LPS localization to cell outer membrane
Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location.
diacylglyceride carrier activity
Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane.
sphingomyelin carrier activity
sphingosine transmembrane transporter activity
Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location.
phosphatidylglycerol carrier activity
Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location.
cerebroside carrier activity
Catalysis of the movement of phosphatidylethanolamine from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP.
phosphatidylethanolamine floppase activity (cytosolic to exoplasmic leaflet)
Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane.
intermembrane phosphatidylserine carrier activity
Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location.
triglyceride carrier activity
Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
phosphatidylcholine flippase activity (exoplasmic to cytosolic leaflet)
Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
phosphatidylserine flippase activity (exoplasmic to cytosolic leaflet)
Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
N-retinylidene-phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaflet)
Catalysis of the movement of lysophosphatidylcholine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
lysophosphatidylcholine flippase activity (exoplasmic to cytosolic leaflet)
Catalysis of the movement of glycosylceramide from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP. Glycosylceramides are ceramides containing a functional group derived from a sugar.
galactocerebroside flippase activity
galactosylceramide flippase activity
glucosylceramide flippase activity
glycoceramide flippase activity
glycosylceramide flippase activity (exoplasmic to cytosolic leaflet)
The activity of a gene product that interacts with a cargo receptor and initiates endocytosis.
cargo
A ribonucleoprotein granule located in the cytoplasm and the nucleus. GW-bodies minimally contain the Argonaute2 (Ago2) and TNRC6B proteins, together with specific target RNAs.
GW-body
A ribonucleoprotein granule located in the cytoplasm of bacteria, minimally containing the RNase E protein and RNA molecules. Bacterial RNP-bodies are similar to eukaryotic P-bodies and stress granules.
BR-body
A receptor complex that recognizes, binds and sequesters a specific receptor ligand to prevent it from binding to its regular receptor. May be soluble or membrane bound.
osteoclastogenesis inhibitory factor
osteoprotegerin complex
Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) = 2 S-adenosyl-L-homocysteine + psilocybin.
norbaeocystin methyltransferase
psilocybin synthase
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) + HO3Se-(out) = zinc(in) + HCO3-(in) + HO3Se-(out).
zinc:hydrogencarbonate:selenate symporter activity
A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.
DNA-binding transcription factor inhibitor activity
Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts.
ATP-sensitive calcium-release channel activity
The directed movement into cell of externally available heme by receptor-mediated endocytosis.
heme assimilation
A process mediated by a molecule secreted by a symbiont that results in the suppression of a pattern-triggered immunity PTI signaling pathway. PTI signaling pathways are found in plants.
effector-mediated suppression of host pattern recognition receptor signaling
effector-mediated suppression of host PRR signaling
effector-mediated suppression of host PRR signalling
effector-mediated suppression of pattern-triggered immunity signaling
effector-mediated suppression of PTI signalling
The series of molecular signals initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. PAMP-triggered immunity PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
MAMP-triggered immunity signalling
PAMP receptor signaling pathway
PAMP-triggered immunity signalling pathway
pathogen-associated molecular pattern signalling
PTI signalling
Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed.
correction of merotelic kinetochore attachment, mitotic
correction of mono-orientation defects
correction of syntelic kinetochore attachment, mitotic
repair of mitotic merotelic kinetochore attachment defect
repair of mitotic merotelic kinetochore attachment defects
repair of mitotic mono-orientation defect
repair of mitotic mono-orientation defects
Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base.
DNA AP site binding
DNA-(apurinic site) binding
DNA-(apurinic site/apyrimidinic site) binding
DNA-(apyrimidinic site) binding
The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.
mitochondrion plasma membrane adaptor activity
mitochondrion plasma membrane tether activity
plasma membrane-mitochondrion adaptor activity
plasma membrane-mitochondrion tether activity
The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane.
cytoskeletal protein-nuclear membrane adaptor activity
cytoskeletal protein-nuclear membrane anchor activity
cytoskeleton nuclear membrane anchor activity
nuclear membrane-cytoskeleton anchor activity
The chemical reactions and pathways resulting in the formation of fumigermin, an alpha-pyrone secondary metabolite found in some species of fungi such as Aspergillus fumigatus.
fumigermin anabolism
fumigermin biosynthesis
fumigermin formation
fumigermin synthesis
The cleavage of a peptide bond in a precursor form of a cytokine, resulting in the mature (active) form of the cytokine.
interleukin maturation
interleukin processing
The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location.
centromere nuclear envelope anchor activity
centromere nuclear envelope tether activity
centromere-inner nuclear envelope anchor activity
centromere-inner nuclear envelope tether activity
chromosome, centromeric region-nuclear envelope anchor activity
nuclear envelope-centromere anchor activity
nuclear envelope-centromere tether activity
Reversible aggregate of misfolded proteins and chaperones formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.
PAC
protein aggregate centre
The reversible aggregation of misfolded proteins and chaperones, formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.
PAC assembly
protein aggregate center formation
protein aggregate centre assembly
The release of duplicated meiotic spindle pole bodies (SPBs).
initial spindle pole body separation involved in meiosis I
meiotic spindle pole body duplication
The localization of silent mating-type cassette heterochromatin at a specific location in the nucleus.
silent mating-type cassette heterochromatin organization
silent mating-type cassette heterochromatin spatial organization in the nucleus
A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock.
EIF2AK1-mediated signaling
A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation.
EIF2AK4-mediated signaling
regulation of eIF2 alpha phosphorylation by amino acid starvation
Any process that activates or increases the frequency, rate or extent of transepithelial migration of symbiont in host.
positive regulation of symbiont-mediated migration across host transepithelium
positive regulation of symbiont-mediated migration through host transepithelium
positive regulation of transmigration of symbiont in host
The binding activity of a molecule that brings together the telomeric region of a chromosome and the inner nuclear membrane by interacting with both the telomere and the nuclear membrane, in order to establish and maintain the telomeric location.
nuclear envelope-telomere anchor activity
telomere-nuclear envelope anchoring activity
The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.
endoplasmic reticulum-mitochondrion membrane adaptor activity
endoplasmic reticulum-mitochondrion membrane tether activity
ER-mitochondrion membrane adaptor activity
ER-mitochondrion membrane tether activity
mitochondrion-endoplasmic reticulum membrane adaptor activity
mitochondrion-ER membrane adaptor activity
mitochondrion-ER membrane tether activity
A process in which the duplicated mitotic spindle pole body is inserted into a fenestra which opens in the nuclear envelope in early mitosis, and is subsequently tethered to the membrane.
establishment of spindle pole body localisation in nuclear envelope
establishment of spindle pole body localization in nuclear envelope
establishment of spindle pole body localization to nuclear envelope
Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out).
ATPase-coupled Fe-S cluster transmembrane transporter activity
ATPase-coupled iron-sulfur cluster transmembrane transporter activity
The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way.
inner kinetochore adaptor activity
outer kinetochore adaptor activity
The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly.
microtubule nucleation template activity
An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
metal-dependent ubiquitin-like hydrolase activity
metal-dependent ubiquitinyl-like hydrolase activity
Any process that increases the frequency, rate or extent of reticulophagy.
positive regulation of autophagy of the endoplasmic reticulum
positive regulation of autophagy of the ER
positive regulation of endoplasmic reticulum autophagy
positive regulation of endoplasmic reticulum degradation
positive regulation of ER autophagy
positive regulation of ER degradation
positive regulation of ER-phagy
A process mediated by a molecule secreted by a symbiont that results in the suppression of host salicylic acid-mediated innate immune signaling.
effector-mediated disruption of host salicylic acid-mediated innate immune signalling
effector-mediated suppression of host salicylic acid-mediated innate immune signalling
The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy.
autophagosome-endoplasmic reticulum anchor
autophagosome-ER anchor
ER- autophagosome anchor
The mitotic cell cycle process in which the controlled breakdown of the nuclear pores occurs during open or closed mitosis.
nuclear pore complex disassembly during mitosis
A GTPase activity that mediates the joining two lipid bilayers to form a single membrane.
membrane fusion GTPase activity
The pole of the kinetoplast associated with kinetoplast DNA replication. The antipodal sites flank the kinetoplast DNA disk and are positioned approximately 180 degrees apart. In Trypanosoma brucei and Crithidia fasciculata, minicircles are attached at antipodal sites and they contain enzymes that catalyse some of the later reactions in minicircle replication.
antipodal zone
The assembly and organization of a bilobe structure, a cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone).
bilobe structure biogenesis
bilobe structure formation
kinetoplastid flagellar hook complex assembly
The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly.
MCM complex loading at replication origin
MCM double hexamer formation at replication origin
A process by which a symbiont inhibits or disrupts the host's RNAi-mediated antiviral immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
suppression of host RNAi-mediated antiviral immune response
suppression of host RNAi-mediated antiviral immunity
suppression of host RNAi-mediated gene silencing
A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
nuclear corepressor activity
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising the septin collar.
cellular bud neck septin hourglass organization
An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates.
protein disaggregase activity
protein unfoldase activity
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with specific proteins binding to cell-surface carbohydrates and causing calcium-dependent agglutination of blood cells in the bitten organism.
envenomation resulting in blood agglutination in other organism
envenomation resulting in erythrocytes agglutination in other organism
envenomation resulting in red blood cells agglutination in other organism
The membrane surrounding the spore core (endospore core) that separates it from its external environment.
spore membrane
Binding to and responding, e.g. by conformational change, to changes in the cellular level of phosphatidylinositol-4,5-bisphosphate.
phosphatidylinositol-4,5-bisphosphate sensing activity
A transcription factor complex that is composed of the one DNA binding protein of the TEAD family and the transcriptional coactivator YAP.
TEAD-1-YAP complex
TEAD-2 multiprotein complex
TEAD-2-YAP complex
TEAD-3-YAP complex
TEAD-4-YAP complex
The activity of removing a protein from a membrane, by binding to a transmembrane helical fragment of a tail-anchored protein and releasing it from the the hydrophobic region of one or both lipid bilayers. The reaction is driven by ATP hydrolysis.
transmembrane helix dislocase\ntransmembrane protein dislocase activity
The removal of a mislocalized protein from the mitochondrial outer membrane.
extraction of mislocalized protein from outer mitochondrion membrane