NothingMuch/GO-Terms huggingface dataset:
The chemical reactions and pathways resulting in the formation of (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds.
(1->4)-alpha-D-glucan anabolism
(1->4)-alpha-D-glucan biosynthesis
(1->4)-alpha-D-glucan formation
(1->4)-alpha-D-glucan synthesis
1,4-alpha-glucan anabolism
1,4-alpha-glucan biosynthesis
1,4-alpha-glucan biosynthetic process
1,4-alpha-glucan formation
1,4-alpha-glucan synthesis
alpha-1,4 glucan anabolism
alpha-1,4 glucan biosynthesis
alpha-1,4 glucan biosynthetic process
alpha-1,4 glucan formation
alpha-1,4 glucan synthesis
Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose.
N-ribosylnicotinamide hydrolase activity
nicotinamide ribonucleoside hydrolase activity
Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose.
D-ribosylnicotinate hydrolase activity
D-ribosylnicotinic acid hydrolase activity
nicotinate ribonucleoside hydrolase activity
nicotinate riboside hydrolase activity
nicotinic acid ribonucleoside hydrolase activity
The chemical reactions and pathways involving vitamin D2, (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol.
calciferol metabolic process
ergocalciferol metabolic process
vitamin D2 metabolism
The chemical reactions and pathways involving vitamin D4, (3S,5Z,7E)-9,10-secoergosta-5,7,10(19)-trien-3-ol.
vitamin D4 metabolism
The chemical reactions and pathways involving vitamin D5, (1S,3Z)-3--7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol.
vitamin D5 metabolism
Binding to a vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum.
VDRE binding
A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development.
orbicule
An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system.
NRD
A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex.
HAUS augmin complex
Binding to a high-density lipoprotein receptor.
HDL receptor binding
high-density lipoprotein receptor binding
Any process that stops, prevents or reduces the rate or extent of mast cell proliferation.
down regulation of mast cell proliferation
down-regulation of mast cell proliferation
downregulation of mast cell proliferation
inhibition of mast cell proliferation
Any process that activates or increases the rate or extent of mast cell proliferation.
activation of mast cell proliferation
stimulation of mast cell proliferation
up regulation of mast cell proliferation
up-regulation of mast cell proliferation
upregulation of mast cell proliferation
Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+.
hypoxanthine oxidoreductase activity
hypoxanthine-NAD oxidoreductase activity
hypoxanthine/NAD(+) oxidoreductase activity
hypoxanthine/NAD+ oxidoreductase activity
hypoxanthine:NAD+ oxidoreductase activity
NAD-hypoxanthine dehydrogenase activity
Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2.
hypoxanthine-xanthine oxidase activity
hypoxanthine:O2 oxidoreductase activity
hypoxanthine:oxygen oxidoreductase activity
schardinger enzyme
Schardinger enzyme activity
xanthine oxidoreductase activity
Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing.
unprocessed protein binding
Binding to inositol 1,4,5 trisphosphate.
InsP3 binding
IP3 binding
The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex.
proteasome regulatory complex assembly
The reproductive process in which coagulated semen becomes liquid following ejaculation, allowing the progressive release of motile spermatozoa.
semen liquefaction
The portion of the plasma membrane surrounding a macropinocytic cup.
crown membrane
The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup.
crown cytoskeleton
The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate.
L-threonine breakdown to propionate
L-threonine catabolism to propionate
L-threonine degradation to propionate
threonine catabolic process to propionate
The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) into glycine and acetaldehyde, with acetaldehyde being subsequently converted to acetyl-CoA.
L-threonine breakdown to acetyl-CoA
L-threonine catabolism to acetyl-CoA
L-threonine degradation to acetyl-CoA
threonine catabolic process to acetyl-CoA
A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T.
Bur1/Bur2 complex
cyclin-dependent kinase 9 (Cdk9)-cyclin T1 complex
cyclin-dependent kinase 9 (Cdk9)-cyclin T2 complex
dimeric positive transcription elongation factor complex b
Sgv1/Bur2 complex
A positive transcription elongation factor complex that comprises the CDK kinase CTK1 (in budding yeast), Lsk1 (in fission yeast) (corresponding to the Panther PTHR24056:SF39 family), a cyclin and an additional gamma subunit (corresponding to the InterPRO entry IPR024638).
C-terminal domain kinase I complex
CTDK-I complex
Ctk complex
trimeric positive transcription elongation factor complex b
A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase.
Cdk9-Pcm1 complex
P-TEFb-Pcm1 complex
Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base.
deoxynucleoside 5\'-monophosphate N-glycosidase activity
Binding to a BMP receptor.
bone morphogenetic protein receptor binding
The modification of an RNA molecule by insertion of a cytidine nucleotide.
RNA C insertion
The modification of an RNA molecule by insertion of a guanosine nucleotide.
RNA G insertion
The modification of an RNA molecule by removal of a uridine nucleotide.
RNA U deletion
RNA uridine excision
The modification of an RNA molecule by insertion of an adenosine-uridine dinucleotide.
RNA AU insertion
The modification of an RNA molecule by insertion of an cytidine-uridine dinucleotide.
RNA CU insertion
The modification of an RNA molecule by insertion of an guanosine-cytidine dinucleotide.
RNA GC insertion
The modification of an RNA molecule by insertion of an guanosine-uridine insertion dinucleotide.
RNA GU insertion
A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.
PDGFRA-SHP-2 complex, PDGF stimulated
A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.
PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated
A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway.
GRB2-SHP-2 complex, PDGF stimulated
A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein.
interferon-stimulated gene factor 3 transcription complex
A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product.
Grg3b-Grg5 complex
A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits.
bone morphogenetic protein receptor complex
Binding to L-leucine, 2-amino-4-methylpentanoic acid.
Leu binding
leucine binding
The directed movement of cyclic AMP (cAMP), into, out of or within a cell.
cyclic AMP transport
The directed movement of cyclic GMP (cGMP), into, out of or within a cell.
cyclic GMP transport
Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins.
adenosine monophosphate-protein transferase activity
AMPylator
protein adenylyltransferase activity
Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein.
protein glycylase activity, initiating
Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain.
protein glycylase activity, elongating
Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin.
tubulin glycylase activity
Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.
tubulin glutamylase activity
tubulin-glutamate ligase activity
A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space.
IL-23 complex
IL12B
IL23A
p19
p40
A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space.
EBI3
IL-27 complex
IL27
p28
A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space.
EBI3
IL-35 complex
IL12A
p35
Binding to interleukin-35.
IL-35 binding
Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
IL-35 receptor activity
IL-35R
Binding to an interleukin-35 receptor.
IL-35
interleukin-35 receptor ligand
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production.
down regulation of interleukin-35 production
down-regulation of interleukin-35 production
downregulation of interleukin-35 production
inhibition of interleukin-35 production
negative regulation of IL-35 production
negative regulation of interleukin-35 biosynthetic process
Any process that activates or increases the frequency, rate, or extent of interleukin-35 production.
activation of interleukin-35 production
positive regulation of IL-35 production
positive regulation of interleukin-35 biosynthetic process
stimulation of interleukin-35 production
up regulation of interleukin-35 production
up-regulation of interleukin-35 production
upregulation of interleukin-35 production
Any process that decreases the rate, frequency or extent of an interleukin-35-mediated signaling pathway.
negative regulation of IL-35-mediated signaling pathway
negative regulation of interleukin-35-mediated signalling pathway
Any process that increases the rate, frequency or extent of an interleukin-35-mediated signaling pathway.
positive regulation of IL-35-mediated signaling pathway
positive regulation of interleukin-35-mediated signalling pathway
A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes.
pre-small nucleolar ribonucleoprotein complex
A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex.
NDC1 complex
NDC1 subcomplex
A protein complex that consists of homodimer of the Notch ligand Delta1.
Delta1 homodimer complex
A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.
CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)
gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)
gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)
gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)
gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
presenilin complex
PS1 complex
PS2 complex
A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof).
SNARE complex (Stx4, Napa, Vamp3, Nsf, Vamp2)
Stx4-Napa-Vamp3-Nsf-Vamp2 complex
A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof).
Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex
SNARE complex (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a)
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin.
ITGA2B-ITGB3-CIB1 complex
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK.
ITGA2b-ITGB3-CD47-FAK complex
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src.
ITGA2b-ITGB3-CD47-SRC complex
A phosphatidylinositol kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKFYVE in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
autophagy-specific phosphatidylinositol 3-kinase complex
Catalysis of the reaction: N-terminal L-glutaminyl- + H2O = N-terminal L-glutamyl- + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein.
NtQ-amidase activity
Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate.
dihydrosphingosine-1-phosphate phosphohydrolase activity
sphinganine-1-phosphate phosphatase activity
The process in which glycerol-2-phosphate is transported across a membrane. Glycerol-2-phosphate is a phosphoric monoester of glycerol.
glycerol-2-phosphate transport
Any process in which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location.
establishment and maintenance of P-TEFb-cap methyltransferase complex localization
P-TEFb-cap methyltransferase complex localisation
Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone.
protoporphyrinogen-IX:menaquinone oxidoreductase activity
A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures.
Snf2/HDAC containing repressor complex
Snf2/Hdac repressive complex
The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane.
caveola formation
caveolar biogenesis
The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C.
dehydroascorbate transport
Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
dynein binding
The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell.
misfolded polyubiquitinated protein transport
polyubiquitylated misfolded protein transport
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
C mediator complex
S mediator complex
A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.
cell body fibre
primary neurite
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
down regulation of bile acid biosynthetic process
down-regulation of bile acid biosynthetic process
downregulation of bile acid biosynthetic process
inhibition of bile acid biosynthetic process
negative regulation of bile acid anabolism
negative regulation of bile acid biosynthesis
negative regulation of bile acid formation
negative regulation of bile acid synthesis
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
activation of bile acid biosynthetic process
positive regulation of bile acid anabolism
positive regulation of bile acid biosynthesis
positive regulation of bile acid formation
positive regulation of bile acid synthesis
stimulation of bile acid biosynthetic process
up regulation of bile acid biosynthetic process
up-regulation of bile acid biosynthetic process
upregulation of bile acid biosynthetic process
A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization.
F-actin cone
The portion of the plasma membrane surrounding a mating projection tip.
mating projection membrane fusion domain
shmoo tip membrane
Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.
pri-miRNA binding
primary microRNA binding
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
down regulation of calcineurin-NFAT signaling cascade
down-regulation of calcineurin-NFAT signaling cascade
downregulation of calcineurin-NFAT signaling cascade
inhibition of calcineurin-NFAT signaling cascade
inhibition of NFAT protein import into nucleus
negative regulation of calcineurin-NFAT signaling pathway
negative regulation of calcineurin-NFAT signalling cascade
negative regulation of NFAT protein import into nucleus
termination of calcineurin-NFAT signaling cascade
Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.
activation of calcineurin-NFAT signaling cascade
positive regulation of calcineurin-NFAT signaling pathway
positive regulation of calcineurin-NFAT signalling cascade
positive regulation of NFAT protein import into nucleus
stimulation of calcineurin-NFAT signaling cascade
up regulation of calcineurin-NFAT signaling cascade
up-regulation of calcineurin-NFAT signaling cascade
upregulation of calcineurin-NFAT signaling cascade
Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
E-box promoter binding
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets.
platelet alpha granule organisation
platelet alpha granule organization and biogenesis
platelet alpha-granule organization
Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response.
lipoteichoic acid receptor activity
The formation of a large multiprotein-DNA complex that self-assembles on a tRNA gene through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC), (which includes BDP1, BRF1, TBP, TFIIIC in human). The PIC engages RNA polymerase III on its DNA template strand and sparks polymerization of the first few RNA nucleotides.
RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly
RNA polymerase III transcription PIC biosynthesis
RNA polymerase III transcription PIC formation
RNA polymerase III transcriptional preinitiation complex assembly
RNA polymerase III transcriptional preinitiation complex formation
RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly
RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly
Binding to 2-amino-3-hydroxypropanoic acid.
Ser binding
Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out).
aspartate-alanine antiporter activity
aspartate/alanine antiporter activity
Catalysis of the reaction: L-histidine(out) + histamine(in) = L-histidine(in) + histamine(out).
histidine-histamine antiporter activity
histidine/histamine antiporter activity
histidine:histamine antiporter activity
Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out).
tyrosine-tyramine antiporter activity
tyrosine/tyramine antiporter activity
Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out).
glutamate-gamma-aminobutyric acid antiporter activity
glutamate/gamma-aminobutyric acid antiporter activity
glutamate: GABA antiporter activity