NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: an ecdysteroid + ATP = an ecdysteroid 22-phosphate + ADP + H+.
EcKinase
The chemical reactions and pathways resulting in the formation of a Lewis x epitope, a trisaccharide (beta-D-galactosyl-(1,4)--N-acetyl-beta-D-glucosamine) expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system. The related Lewis x epitope is formed by alpha(1,3) fucosylation of the N-acetylglucosaminyl residue of a type 2 histo-blood group antigen precursor disaccharide.
sialyl-Lewis X biosynthetic process
sLeX biosynthetic process
Catalysis of the reaction: Glc(2)Man(9)GlcNAc(2)- + H2O = GlcMan(9)GlcNAc(2)- + beta-D-glucopyranose.
glucosidase II
Catalysis of the reaction: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate.
cyclic-di-AMP synthase
Catalysis of the reaction: ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate.
murein peptide ligase
Catalysis of the reaction: C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl- + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl- + L-tyrosine.
tubulinyl-Tyr carboxypeptidase
Catalysis of the reaction: L-dopa + O2 + H2O + H+ = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH(4)+ + H2O2.
DHPAA synthase
Catalysis of the reaction: a N-D-queuosine + H2O = queuine + D-ribose.
queuosine nucleoside glycosylase
tRNA queuosine nucleoside glycosylase
Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+.
ali-esterase activity
alpha-carboxylesterase activity
B-esterase activity
cocaine esterase
nonspecific carboxylesterase activity
procaine esterase   {comment=EC:3.1.1.1}
serine esterase activity
triacetin esterase
vitamin A esterase
Catalysis of the reaction: a quinone + glutathione + H+ + hydrogen sulfide = a quinol + S-sulfanylglutathione.
eukaryotic sulfide quinone oxidoreductase
Any process in which a protein is transported to, or maintained at, a P-body.
protein localisation to P-body
protein localization to cytoplasmic mRNA processing body
protein localization to P body
The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate circular mRNA translation.
IRES-dependent translational initiation of circRNA
Any process that stops, prevents, or reduces the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway.
negative regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway
The chemical reactions and pathways resulting in the breakdown of lncRNAs, non-coding RNAs over 200 nucleotides in length.
lncRNA breakdown
lncRNA catabolism
lncRNA degradation
Any process that stops, prevents, or reduces the frequency, rate or extent of mitotic telomere clustering during interphase.
negative regulation of mitotic telomere clustering during interphase
telomere dispersion during interphase
High affinity ammonium transporter complex that enables the transfer of ammonium from one side of a membrane to the other.
AMT1 complex
A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane.
endosomal trafficking
A Hsp90 cochaperone complex acting as an adapter between Hps90 and its substrates, members of the PIKK kinase family.
Tel2-Tti1-Tti2
TELO2-TTI1-TTI2
Triple T complex
TTT complex
The area of a motile nucleus closest to the direction of movement.
horsetail nucleus leading edge
Any process that mediates the transfer of information from one cell to another using polyphosphate as the signal.
polyphosphate signaling
The aggregation, arrangement and bonding together of a set of components to form a ribulose bisphosphate carboxylase complex.
RuBisCO assembly
A conserved protein complex capable of 5'-3' exoribonuclease activity. It is able to promote RNA polymerase II (RNAPII) transcription termination by degrading pre-mRNA from the newly formed 5' phosphorylated end.
TXT complex
A megadalton-sized complex at the medial cortex organized as an oligomeric core of SAD family protein kinases involved in cell size-dependent localization and phosphorylation of Wee1 during interphase.
interphase cortical node
interphase node
A complex that localizes to actin cortical patches at sites of endocytosis and negatively regulates barbed end F-actin assembly, resulting in the generation of free actin pools. The Aim21-Tda2 complex is necessary for efficient endocytosis and balancing the distribution of actin between patches and cables.
Aim21/Tda2 complex
The acquisition, loss, or modification of macromolecules within a protein-RNA complex, resulting in the alteration of an existing complex.
protein-RNA complex remodelling
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum attachment zone. FAZ is a network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species.
FAZ organization
flagellum attachment zone organisation
A protein complex composed of enzymes and accessory factors of the ubiquinone (CoQ) biosynthesis pathway. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K. In eukaryotes, the complex is located on the matrix face of the inner mitochondrial membrane and includes COQ3, COQ4, COQ5, COQ6, COQ7, COQ9.
complex Q
CoQ Biosynthetic Complex
CoQ metabolon
CoQ-synthome
Ubi complex
Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H+ + NAD+.
RNA NAD-cap (NAD-forming) hydrolase activity
A calcium-dependent protease complex that processes its substrate by limited proteolysis rather than degrading it. In some cases limited proteolysis is required for the activation of its substrate.
M-calpain
mu-calpain
Any DNA biosynthetic process that is involved in mitochondrial DNA replication.
DNA biosynthetic process involved in mitochondrial DNA replication
A scallop-shaped plaque, also referred to as an asymmetric unit membrane (AUM), found in the apical plasma membrane of urothelial superficial (umbrella) cells which form a a barrier to the passage of water and soluble toxic compounds found in urine. The plaques are thickened regions of membrane composed of uroplakin transmembrane proteins which form a crystalline array.
asymmetric unit membrane
AUM
Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
intermembrane phosphatidylcholine transfer activity
phosphatidylcholine carrier activity
Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
cholesterol carrier activity
cholesterol transporter activity
intermembrane cholesterol transfer activity
Removes oxysterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
intermembrane oxysterol transfer activity
oxysterol carrier activity
Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP).
glucagon binding
glucagon-like peptide binding
A host cell membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.
host cell uropodium
The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region.
hydrogen ion export across plasma membrane
hydrogen ion export from cell
proton export from cell
The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium.
stereocilium taper
Migration of ingested material along the length of the large intestine.
colon transit
colonic transit
large bowel transit
large intestine transit
Any process that increases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine.
positive regulation of small bowel transit
positive regulation of small intestine transit
Any process that decreases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine.
negative regulation of small bowel transit
negative regulation of small intestine transit
Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene.
asterisca-2(9),6-diene synthase activity
Catalyzes the hydroxylation of jasmonic acid to 12OH-jasmonic acid.
2-oxoglutarate dioxygenase
An organelle membrane contact site formed at the junction of the vacuolar membrane and the isolation membrane or phagophore in response to starvation or other stresses, leading to the formation of the autophagosome.
vacuole-IM contact site
vacuole-phagophore contact site
VICS
A protein complex that is involved in the transfer of the second mannose to the glycosylphosphatidylinositol (GPI) during GPI precursor assembly. In yeast S. cerevisiae this complex consists of GPI18p and PGA1p.
GPI-MT-I complex
A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species.
bacterial-type flagellum motor force generator complex
bacterial-type flagellum torque generator complex
A part of the bacterial-type flagellum that is located at the cytoplasmic side of the MS ring and composed of six membrane proteins (FlhA, FlhB, FliP, FliQ, FliR, and FliO, or orthologs thereof) and three soluble proteins (FliI, FliH, and FliJ, or orthologs thereof) in the cytoplasm. It is responsible for secretion of flagellar type III protein substrates, including the proteins of the flagellar rod, hook, and filament.
bacterial-type flagellum export apparatus
A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68.
subdistal appendage of basal body
subdistal appendage of centriole
subdistal appendage of mother centriole
The region of the mitotic actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located.
actomyosin contractile ring, proximal layer
The region of the mitotic actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer.
actomyosin contractile ring, intermediate layer
The region of the mitotic actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to.
actomyosin contractile ring, distal actin filament layer
Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP.
DNA-3\'pp5\'G guanylate hydrolase
A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe.
protein localization by the Nbr1-mediated vacuolar targeting pathway
The random-like motility observed for T cells in lymph nodes which enhances surveillance of antigens presented by major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs).
lymph node surveillance
T cell meandering search
A network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species.
FAZ
A cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone).
kinetoplastid flagellar hook complex
A three-part cytoskeletal structure in kinetoplastid species linking mitochondrial DNA organised in a kinetoplast through the mitochondrial membranes to the basal body.
TAC
The chemical reactions and pathways involving prolactin, a protein hormone of the anterior pituitary gland that promotes lactation in response to the suckling stimulus of hungry young mammals.
prolactin metabolism
A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
E1 complex
E1 ubiquitin-activating enzyme
A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes.
GATE-16 complex
LMA1 complex
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in the bone marrow.
activation of apoptosis in bone marrow
positive regulation of apoptosis in bone marrow
positive regulation of apoptotic process in bone marrow
positive regulation of bone marrow cell apoptosis
positive regulation of bone marrow cell programmed cell death by apoptosis
positive regulation of killing of bone marrow cells
positive regulation of programmed cell death of bone marrow cells by apoptosis
positive regulation of programmed cell death, bone marrow cells
up regulation of apoptosis in bone marrow
up-regulation of apoptosis in bone marrow
upregulation of apoptosis in bone marrow
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin cortical patches.
down regulation of actin cortical patch assembly
down-regulation of actin cortical patch assembly
downregulation of actin cortical patch assembly
inhibition of actin cortical patch assembly
The portion of the axoneme that is close to the base of the cilium.
proximal part of axoneme
The portion of the axoneme that is close to the tip of the cilium.
distal part of axoneme
Catalysis of the reaction: ATP + dUMP = ADP + dUDP.
ATP:dUMP phosphotransferase activity
deoxyuridine monophosphate kinase activity
dUMP-kinase activity
Any process that activates or increases the frequency, rate or extent of any ecdysone receptor signaling pathway.
positive regulation of ecdysone receptor-mediated signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of any ecdysone receptor signaling pathway.
negative regulation of ecdysone receptor-mediated signaling pathway
A process in which a protein is transported to, or maintained in, a location within a basal ectoplasmic specialization.
protein localisation in basal ectoplasmic specialization
protein localisation to basal ectoplasmic specialization
protein localization in basal ectoplasmic specialization
Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group.
3-O-sulfogalactosylceramide binding
SM4 binding
sulfated galactocerebroside binding
A structure in a host cell comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
host centrosome
A small host cell organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
host peroxisome
A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins.
Mlc1p-Iqg1p-Hof1p complex
A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC.
apical polarity complex
BEM1-CDC24-CLA4 complex
Cdc42p GEF-PAK complex
PAR3-PAR6-atypical PKC
PAR3/PAR6/aPKC
PAR6-PAR3-aPKC complex
Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.
activation of collagen catabolic process
positive regulation of collagen breakdown
positive regulation of collagen catabolism
positive regulation of collagen degradation
up regulation of collagen catabolic process
up-regulation of collagen catabolic process
upregulation of collagen catabolic process
Binding to an intraciliary transport particle A (IFT A) complex.
IFT A complex binding
intraciliary transport complex A binding
intraflagellar transport complex A binding
intraflagellar transport particle A binding
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
positive regulation of CIT
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
negative regulation of CIT
The series of events in which a hot stimulus is received and converted into a molecular signal as part of thermoception.
sensory detection of heat stimulus during thermoception
sensory detection of hot stimulus during thermoception
sensory transduction of heat stimulus during thermoception
sensory transduction of hot stimulus during thermoception
thermoception, sensory detection of heat stimulus
thermoception, sensory detection of hot stimulus
thermoception, sensory transduction of heat stimulus
thermoception, sensory transduction of hot stimulus
The series of events in which a cold stimulus is received and converted into a molecular signal as part of thermoception.
sensory detection of cold stimulus during thermoception
sensory transduction of cold stimulus during thermoception
thermoception, sensory detection of cold stimulus
thermoception, sensory transduction of cold stimulus
Binding to an intraciliary transport particle B (IFT B) complex.
IFT B complex binding
intraciliary transport complex B binding
intraflagellar transport complex B binding
intraflagellar transport particle B binding
A complex that forms at the cell cortex in response to pheromone treatment and is required for the polarized growth of haploid yeast cells towards a mating partner during yeast mating. In the yeast Saccharomyces cerevisiae, this complex consists of Cdc24p, Far1p, Ste4p (G-protein beta subunit) and Ste18p (G-protein gamma subunit).
CDC24-FAR1-BG complex
CDC24-FAR1-Gbetagamma complex
Cdc24p-Far1p-BG complex
A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway.
SHRED pathway
The aggregation, arrangement and bonding together of a set of components to form an MBF transcription complex.
DSC1 transcription factor complex assembly
MBF complex assembly
Mlu1-box binding factor assembly
The respiratory system process driven by motile cilia on epithelial cells of the respiratory tract by which mucus and associated inhaled particles and pathogens trapped within it are moved out of the airways.
MCC
MCT
mucociliary transport
The proximal region of the photoreceptor connecting cilium is similar to the transition zone of unspecialized primary cilia and houses several major transition zone complexes, including NPHP, MKS, and RPGR.
PCC
photoreceptor PCC
The distal region of the photoreceptor connecting cilium is structurally unique to the photoreceptor and is maintained by retina-specific protein, SPATA7, and its interacting partners RPGR and RPGRIP1. It is essential for photoreceptor sensory cilium stability.
DCC
photoreceptor DCC
A centrosome-based structure consisting of two cylindrical microtubule-based centrioles and associated components which anchors the flagellum to the sperm head.
head-tail coupling apparatus
HTCA
implantation fossa
sperm connecting piece
sperm neck
Any process that stops, prevents or reduces the frequency, rate or extent of histidine biosynthetic process.
down regulation of histidine anabolism
down regulation of histidine biosynthesis
down regulation of histidine biosynthetic process
down regulation of histidine formation
down regulation of histidine synthesis
down-regulation of histidine anabolism
down-regulation of histidine biosynthesis
down-regulation of histidine biosynthetic process
down-regulation of histidine formation
down-regulation of histidine synthesis
downregulation of histidine anabolism
downregulation of histidine biosynthesis
downregulation of histidine biosynthetic process
downregulation of histidine formation
downregulation of histidine synthesis
inhibition of histidine anabolism
inhibition of histidine biosynthesis
inhibition of histidine biosynthetic process
inhibition of histidine formation
inhibition of histidine synthesis
negative regulation of histidine anabolism
negative regulation of histidine biosynthesis
negative regulation of histidine formation
negative regulation of histidine synthesis