NothingMuch/GO-Terms huggingface dataset:
A mycolic acid-rich cell outer membrane containing a lipid bilayer and long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. Found in mycobacteria and related genera (e.g. corynebacteria).
MOM
mycobacterial outer membrane
mycomembrane
A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3.
H3-K14 histone acetyltransferase complex
histone acetyltransferase complex (H3-K14 specific)
histone H3 Lys 14 (H3K14) acetyltransferase complex
histone H3K14 acetyltransferase complex
The component of mycolate outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic to MOM
extrinsic to mycolate outer membrane
extrinsic to mycomembrane
A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix.
calcium ion import into mitochondrion
calcium ion transmembrane import into mitochondrion
mitochondrial calcium ion import
mitochondrial calcium uptake
The process in which an undifferentiated cell acquires the features of a myofibroblast cell.
myofibroblast cell differentiation
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of sugar-phosphate.
cellular response to presence of non-metabolizable sugars
The end of a microtubule that does not preferentially grow (polymerize).
microtubule minus end
An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes.
endosomal sorting complex required for transport
An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence.
transitive RNAi
An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface.
TRAIL-activated extrinsic apoptotic signaling pathway
TRAIL-induced apoptotic signaling pathway
tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway
A ribonucleoprotein granule located in the cytoplasm.
Staufen granule
The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane.
kiss-and-run synaptic vesicle recycling
kiss-and-stay synaptic vesicle recycling
Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate.
recycling endosome localization within postsynapse
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
neuron apoptosis in response to oxidative stress
oxidative stress-induced neuron apoptosis
oxidative stress-induced neuronal apoptosis
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2).
H2O2-induced intrinsic apoptotic signaling pathway
hydrogen peroxide-induced apoptosis
hydrogen peroxide-induced intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to H2O2
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron in response to hydrogen peroxide.
H2O2-induced neuron intrinsic apoptotic signaling pathway
hydrogen peroxide-induced neuron apoptosis
hydrogen peroxide-induced neuronal apoptosis
neuron apoptosis in response to hydrogen peroxide
neuron intrinsic apoptotic signaling pathway in response to H2O2
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
endoplasmic reticulum stress-induced neuron apoptosis
endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
ER stress-induced neuron apoptosis
ER stress-induced neuron intrinsic apoptotic signaling pathway
The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo.
trunk NCC migration
Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.
regulation of translation in response to ER stress
Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress.
regulation of translation initiation in response to ER stress
The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.
eiF2alpha phosphorylation in response to ER stress
regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress
Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.
positive regulation of translation in response to ER stress
The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
endoplasmic reticulum unfolded protein response; IRE1 signaling
ERN1-mediated unfolded protein response
inositol-requiring enzyme 1-mediated unfolded protein response
inositol-requiring transmembrane kinase/endonuclease signal transduction
IRE1 branch of UPR
IRE1 signal transduction pathway
IRE1 signaling in response to endoplasmic reticulum stress
IRE1alpha unfolded protein response
IRE1p unfolded protein response
UPR signaling by IRE1 stress sensor
The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
EIF2AK3-mediated unfolded protein response
endoplasmic reticulum unfolded protein response; PERK signaling
eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response
PERK branch of UPR
PERK signal transduction pathway
PERK signaling in response to endoplasmic reticulum stress
PKR-like ER kinase signal transduction
UPR signaling by PERK stress sensor
The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
activating transcription factor 6 signaling in unfolded protein response
ATF6 branch of UPR
ATF6 signal transduction pathway
ATF6 signaling in response to endoplasmic reticulum stress
ATF6-alpha UPR branch
ATF6-beta UPR branch
endoplasmic reticulum unfolded protein response; ATF6 signaling
UPR signaling by ATF6 stress sensor
The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
endoplasmic reticulum-associated degradation
endoplasmic reticulum-associated protein degradation pathway
ER-associated degradation pathway
protein degradation by ERAD
The removal of one or more mannose residues from a mannosylated protein.
protein de-mannosylation
The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein.
glycoprotein mannose trimming
mannose trimming
The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues.
DA axon guidance
dopaminergic axon guidance
mdDA axon guidance
The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues.
5-HT axon guidance
serotonergic axon guidance
The removal of a sugar or dicarbonyl from a glycated protein.
glycated protein repair
A G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
opioid receptor signaling pathway
opioid receptor signalling pathway
The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
netrin signaling pathway
netrin-activated signal transduction pathway
netrin-activated signalling pathway
netrin-mediated signaling pathway
Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway.
regulation of signaling pathway by receptor endocytosis
Any process in which the internalization of a signaling receptor activates or increases the frequency, rate or extent of signal transduction. Receptor internalization can enhance signaling by concentrating signaling molecules in one location, or by moving a ligand-activated receptor to the location of downstream signaling proteins. Endosomes for example can serve as important intracellular signaling platforms.
positive regulation of signaling pathway by receptor endocytosis
Any process in which internalization of a signaling receptor stops, prevents, or reduces the frequency, rate or extent of signal transduction. Receptor internalization can attenuate or reduce the strength of signaling by reducing the concentration of cell surface receptors available to ligands.
negative regulation of signaling pathway by receptor endocytosis
A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell.
insulin receptor endocytosis
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
receptor activity
receptor activity involved in signal transduction
signalling receptor activity
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles.
endocytic receptor activity
receptor activity
receptor activity involved in receptor-mediated endocytosis
transport receptor activity
The series of molecular signals initiated by apolipoprotein A-I binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
apolipoprotein A-I-mediated signalling pathway
The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor.
addiction receptor signaling pathway
basal signaling
dependence receptor signaling pathway
negative signal transduction
non-classical signal transduction
signal transduction in absence of agonist
A protein complex that contains two G protein-coupled receptors.
G-protein coupled receptor dimer
G-protein coupled receptor dimeric complex
GPCR dimer
The controlled release of a member of the BMP family of proteins from a cell.
BMP protein secretion
bone morphogenetic protein secretion
An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP.
canonical nitric oxide signaling
classical nitric oxide signaling
nitric oxide-cGMP-mediated signal transduction
nitric oxide-cGMP-mediated signaling pathway
nitric oxide-cGMP-mediated signalling pathway
NO-cGMP signaling pathway
An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF).
NF-kappaB cascade
NIK-IKK kinase cascade
NIK-IKK signaling pathway
NIK-IKK-alpha cascade
NIK/NF-kappaB cascade
NIK/NF-kappaB signal transduction
NIK/NF-kappaB signaling
non-canonical NF-KB signaling
noncanonical NF-kappaB signaling
noncanonical nuclear factor kappaB (NF-kappaB) pathway
p52-dependent NF-kappaB signaling
Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
transmembrane collagen receptor activity
The series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
collagen-activated signalling pathway
A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
MAPK14 cascade
osmosensory signaling MAPK cascade
p38 cascade
p38 MAPK cascade
The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein.
receptor tyrosine kinase autophosphorylation
RTK autophosphorylation
tyrosine autophosphorylation
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
vascular endothelial growth factor signalling pathway
VEGF signaling
VEGF-activated signaling pathway
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
vascular endothelial growth factor-activated platelet-derived growth factor receptor signaling pathway
VEGF-A/PDGFR signaling
VEGF-activated PDGFR signalling pathway
VEGF-activated platelet-derived growth factor receptor signalling pathway
VEGF/PDGFR signaling pathway
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another.
positive regulation of cell migration by vascular endothelial growth factor signalling pathway
positive regulation of cell migration by VEGF signaling pathway
VEGF-A-induced cell migration
VEGF-induced cell migration
The series of molecular signals initiated by nodal protein binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
nodal signaling
nodal signalling pathway
The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
Fc receptor signalling pathway
The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
Fc-gamma receptor signalling pathway
The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
Fc-epsilon receptor signalling pathway
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
Fc gamma receptor-dependent phagocytosis
Fc-gamma receptor signalling pathway involved in phagocytosis
Fcgamma receptor-mediated phagocytosis
IgG-mediated phagocytosis
The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals).
ActRIIB.ALK4.EGF-CFC complex formation
nodal receptor complex formation
The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.
Kit signalling pathway
SCF signaling pathway
stem cell factor receptor signaling pathway
stem cell factor signaling pathway
The series of molecular signals initiated by interleukin-2 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-2-mediated signaling pathway
interleukin-2-mediated signalling pathway
The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
C-C chemokine receptor type 7 signaling pathway
CCL19-mediated signaling pathway
chemokine (C-C motif) ligand 19 signalling pathway
The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
C-C chemokine receptor type 7 signaling pathway
CCL21-mediated signaling pathway
chemokine (C-C motif) ligand 21 signalling pathway
The series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.
C-C chemokine receptor CCR7 signalling pathway
CCR7 signaling pathway
The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
EGF receptor family signaling pathway
EGFR family signaling pathway
ErbB signaling
ERBB signalling pathway
The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.
ERBB2 signalling pathway
HER2 signaling pathway
NEU signaling
receptor tyrosine-protein kinase erbB-2 signaling pathway
The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission.
ERBB3 signalling pathway
HER3 signaling pathway
receptor tyrosine-protein kinase erbB-3 signaling pathway
The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
ERBB4 signalling pathway
HER4 signaling pathway
receptor tyrosine-protein kinase erbB-4 signaling pathway
The series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
M-CSF signaling pathway
macrophage colony-stimulating factor signalling pathway