NothingMuch/GO-Terms huggingface dataset:
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated calcium channel activity involved in bundle of His cardiac muscle cell action potential
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated calcium channel activity involved in SA node cardiac muscle cell action potential
voltage-gated calcium channel activity involved in SAN cardiac muscle cell action potential
voltage-gated calcium channel activity involved in sinoatrial node cardiac muscle cell action potential
voltage-gated calcium channel activity involved in sinus node cardiac muscle cell action potential
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated sodium channel activity involved in atrioventricular node cardiac muscle cell action potential
voltage-gated sodium channel activity involved in AV node cardiac muscle cell action potential
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated sodium channel activity involved in bundle of His cardiac muscle cell action potential
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated sodium channel activity involved in SA node cardiac muscle cell action potential
voltage-gated sodium channel activity involved in SAN cardiac muscle cell action potential
voltage-gated sodium channel activity involved in sinoatrial node cardiac muscle cell action potential
voltage-gated sodium channel activity involved in sinus node cardiac muscle cell action potential
The attachment of an atrial cardiomyocyte to an AV node cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.
atrial cardiomyocyte-atrioventricular node cell adhesion involved in cell communication
atrial cardiomyocyte-AV node cell adhesion involved in cell communication
The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.
atrioventricular node cell-bundle of His cell adhesion involved in cell communication
A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.
gap junction channel activity involved in atrial cardiomyocyte-atrioventricular node cell electrical coupling
gap junction channel activity involved in atrial cardiomyocyte-AV node cell electrical coupling
A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.
gap junction channel activity involved in atrioventricular node cell-bundle of His cell electrical coupling
Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells.
cell adhesive protein binding involved in atrial cardiomyocyte-atrioventricular node cell communication
cell adhesive protein binding involved in atrial cardiomyocyte-AV node cell communication
Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells.
cell adhesive protein binding involved in atrioventricular node cell-bundle of His cell communication
Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells.
cell adhesive protein binding involved in SA cardiomyocyte-atrial cardiomyocyte communication
Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated potassium channel activity involved in atrioventricular node cardiac muscle cell action potential
voltage-gated potassium channel activity involved in AV node cardiac muscle cell action potential repolarization
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated potassium channel activity involved in SAN cell action potential
voltage-gated potassium channel activity involved in sinoatrial node cell action potential
voltage-gated potassium channel activity involved in sinus node cell action potential
An angiotensin-mediated signaling pathway that contributes to a circulatory system process carried out by the heart, where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores.
angiotensin receptor signaling pathway via activation of phospholipase C involved in heart process
cardiac angiotensin receptor signaling pathway via activation of PLC
Gq-coupled angiotensin receptor signaling pathway involved in heart process
phospholipase C-activating angiotensin-mediated signaling pathway involved in heart process
PLC-activating angiotensin receptor signaling pathway involved in heart process
An endothelin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.
endothelin receptor signalling pathway involved in heart process
A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point.
U2 accessory factor
U2AF
Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine at position 37 = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine at position 37.
tRNA (L-threonylcarbamoyladenosine(37)-C(2)) methyltransferase activity
tRNA (L-threonylcarbamoyladenosine37-C2-) methyltransferase activity
tRNA m6t6A37 methyltransferase activity
Binding to an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif).
iap binding domain binding
inhibitor of apoptosis binding domain binding
reaper hid grim domain binding
RHG domain binding
Any process that increases the frequency, rate or extent of leaflet formation as a result of the series of molecular signals generated in response to detection of auxin.
positive regulation of leaflet formation by auxin mediated signalling pathway
Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
positive regulation of protein kinase C signaling cascade
positive regulation of protein kinase C signalling cascade
Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
negative regulation of protein kinase C signaling cascade
negative regulation of protein kinase C signalling cascade
Any process that increases the frequency, rate or extent of pericentric heterochromatin formation.
positive regulation of chromatin silencing at centromere
positive regulation of pericentric heterochromatin assembly
Any process that increases the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette.
positive regulation of chromatin silencing at silent mating-type cassette
positive regulation of silent mating-type cassette heterochromatin assembly
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade.
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signalling pathway
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
negative regulation of canonical Wnt receptor signaling pathway
negative regulation of canonical Wnt receptor signalling pathway
negative regulation of canonical Wnt-activated signaling pathway
negative regulation of catenin import into nucleus
negative regulation of catenin protein nuclear translocation
negative regulation of Wnt receptor signaling pathway through beta-catenin
The directed movement of low-density lipoprotein particle from endosomes to lysosomes.
endosome to lysosome transport of LDL
The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, from the lysosome to the endoplasmic reticulum.
lysosome to endoplasmic reticulum cholesterol transport
The attachment of the pre-synaptic cell to the post-synaptic cell via adhesion molecules that contributes to synapse maturation.
trans-synaptic adhesion
The aggregation, arrangement and bonding together of a set of components to form a protein complex that contributes to synapse maturation.
protein complex assembly involved in synapse maturation
Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of actin cytoskeleton organisation by cell-cell adhesion
A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure.
mitochondrial DNA packaging
Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
positive regulation of mitochondrial division
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid. The mitochondrial nucleoid is the region of a mitochondrion to which the DNA is confined.
mitochondrial nucleoid organisation
A process that is carried out at the cellular level which results in the separation of a single continuous mitochondrial membrane into two membranes and contributes to mitochondrial fission.
membrane fission involved in mitochondrial fission
mitochondrial membrane scission
The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission.
establishment of protein localisation in mitochondrial membrane involved in mitochondrial fission
establishment of protein localization in mitochondrial membrane involved in mitochondrial fission
A homeostatic process involved in the maintenance of a steady state level of sphingolipids within a cell.
cellular sphingolipid homeostasis
The chemical reactions and pathways resulting in the formation of sphingolipids that contributes to endoplasmic reticulum membrane organization.
sphingolipid biosynthesis involved in endoplasmic reticulum membrane organisation
A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance.
Golgi apparatus disassembly
Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division.
Golgi apparatus distribution to daughter cells
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine.
positive regulation of thiamin biosynthetic process
A process in which a protein is transported to, or maintained in, a nuclear pore.
protein localisation to nuclear pore
Any process that increases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.
positive regulation of establishment of BBB
Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.
negative regulation of establishment of BBB
Any process that modulates the rate, frequency or extent of radial pattern formation, the regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur.
regulation of radial pattern specification
Any process that increases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light.
positive regulation of phytochrome signaling pathway
positive regulation of red or far-red light signalling pathway
Any process that decreases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light.
negative regulation of phytochrome signaling pathway
negative regulation of red or far-red light signalling pathway
Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.
positive regulation of arachidonic acid secretion
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to somitogenesis.
fibroblast growth factor receptor signalling pathway involved in somitogenesis
The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis.
Wnt receptor signaling pathway involved in somitogenesis
Wnt receptor signalling
Wnt-activated signaling pathway involved in somitogenesis
Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation.
regulation of cell motility involved in somitogenic axis elongation
Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity.
protein localisation involved in establishment of planar polarity
Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
negative regulation of mitochondrial division
Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
axon growth cone collapse
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of canonical Wnt receptor signaling pathway
positive regulation of canonical Wnt receptor signalling pathway
positive regulation of canonical Wnt-activated signaling pathway
positive regulation of catenin import into nucleus
positive regulation of catenin protein nuclear translocation
positive regulation of Wnt receptor signaling pathway through beta-catenin
The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane.
nucleoskeleton anchoring at nuclear membrane
Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion.
positive regulation of mitochondrial DNA synthesis
Any process that decreases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion.
negative regulation of mitochondrial DNA synthesis
Any process that decreases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation.
negative regulation of DNA methylation-dependent heterochromatin assembly
negative regulation of methylation-dependent chromatin silencing
Any process that increases the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid.
positive regulation of chylomicron remodelling
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
platelet disaggregation
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid.
negative regulation of abscisic acid biosynthesis
The process in which the developmental fate of an epidermal cell becomes restricted such that it will develop into a seed trichome, causing a change in the orientation of cell division in the ovule epidermis at or just before anthesis.
seed trichome fate commitment
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall of seed trichomes after cell expansion is complete.
secondary cell wall biosynthesis involved in seed trichome differentiation
seed trichome secondary wall biosynthesis
A process that is carried out at the cellular level which results in the assembly of a granum. A granum is a distinct stack of lamellae seen within chloroplasts.
grana formation
The process aimed at the progression of a sepal giant cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
sepal giant cell formation
A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family.
OIS
Enables the transfer of N-methylnicotinate from one side of a membrane to the other.
N-methylnicotinate transporter activity
Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other.
thiamine diphosphate transporter activity
thiamine pyrophosphate transporter activity
A phytochelatin metabolic process in which a metal is incorporated with phytochelatin to form a complex.
low molecular weight phytochelatin complex formation
LWM phytochelatin complex formation
A phytochelatin metabolic process in which a metal and exogenous sulfur are incorporated with phytochelatin to form a complex.
high molecular weight phytochelatin complex formation
HWM phytochelatin complex formation
The chemical reactions and pathways resulting in the formation of ester derivatives of alkyl caffeate.
alkyl caffeate ester anabolism
alkyl caffeate ester biosynthesis
alkyl caffeate ester formation
alkyl caffeate ester synthesis
Catalysis of the reaction: ATP + myristic acid + CoA = AMP + diphosphate + myristoyl-CoA.
myristoyl-CoA synthetase activity
Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA.
palmitoyl-CoA synthetase activity
Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA.
oleoyl-CoA synthetase activity
Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C.
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, camelliol-C-forming)
Enables the transfer of abscisic acid from one side of a membrane to the other.
abscisic acid transporter activity
The chemical reactions and pathways resulting in the formation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
trehalose biosynthetic process in response to heat stress  systematic_synonym
The chemical reactions and pathways resulting in the degradation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
trehalose catabolic process in response to heat stress  systematic_synonym
A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body.
FAR complex
SIN inhibitory phosphatase (SIP) complex
SIN inhibitory phosphatase complex
SIP complex
striatin interacting phosphatase and kinase complex
STRIPAK signalling complex
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucosinolate(out) + H+(out) = glucosinolate(in) + H+(in).
glucosinolate:hydrogen symporter activity
The directed movement of aspartate into the vacuole across the vacuolar membrane.
vacuolar aspartate import
The directed movement of ornithine into the vacuole across the vacuolar membrane.
vacuolar ornithine import
A homeostatic process involved in the maintenance of a steady state level of aspartate within a cell.
aspartate homeostasis
cellular aspartate homeostasis