NothingMuch/GO-Terms huggingface dataset:
The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
CXCL12 signaling pathway
CXCL12-activated CXCR7 signaling pathway
SDF1 signaling pathway
stromal cell-derived factor-1 signaling pathway
The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
CCL2 signaling pathway
The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.
C-C chemokine receptor type 2 signaling pathway
The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.
C-C chemokine receptor type 4 signaling pathway
chemokine receptor CCR4 signaling pathway
The series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.
CXCR4 signaling pathway
The series of molecular signals initiated by the binding of the peptide hormone prolactin to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
PRL signaling pathway
prolactin-mediated signaling pathway
A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
angiotensin II-mediated signaling pathway
angiotensin receptor signaling pathway
angiotensin-mediated signaling pathway
A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process.
SST receptor signaling pathway
SSTR signaling pathway
A G protein-coupled receptor signaling pathway initiated by a cannabinoid binding to its receptor on the cell surface, and ending with the regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids.
cannabinoid receptor signaling pathway
cannabinoid-activated signaling pathway
cannabinoid-mediated signaling pathway
The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.
neurotrophin receptor signaling pathway
Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response.
macrophage receptor activity
MAMP receptor activity
microbe-associated molecular pattern receptor activity
PAMP receptor activity
pathogen associated molecular pattern receptor activity
PRR
PRR activity
signaling pattern recognition receptor activity
A G protein-coupled receptor signaling pathway initiated by cholecystokinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
CCK signaling
cholecystokinin receptor signaling pathway
The series of molecular signals initiated by an extracellular ligand binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Npn signaling
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
vascular endothelial growth factor-activated neuropilin signaling pathway
VEGF-Npn-1 signaling
Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity.
C2H4 receptor activity
ethylene response sensor
A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K.
mTOR complex
target of rapamycin complex
TOR signaling complex
A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.
TORC1 signal transduction
A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.
TORC2 signal transduction
The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.
pronephros proximal tubule morphogenesis
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state.
cell differentiation involved in pronephric kidney development
Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate.
pattern specification involved in pronephric kidney development
A process by which a symbiont inhibits or disrupts the normal execution of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).
inhibition of host adaptive immune response by virus
negative regulation of host adaptive immune response
negative regulation of host adaptive immunity
suppression by virus of host adaptive immune response
suppression of host acquired immune response
A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
disruption by virus of host JAK-STAT cascade
down-regulation by virus of host JAK-STAT cascade
downregulation by virus of host JAK-STAT cascade
inhibition by virus of host JAK-STAT cascade
negative regulation by virus of host JAK-STAT cascade
suppression by virus of host JAK-STAT cascade
Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host.
regulation by virus of host autophagy
A process in which a symbiont inhibits or disrupts mRNA processing in its host. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. The host is defined as the larger of the organisms involved in a symbiotic interaction.
inhibition by virus of host mRNA processing
inhibition of host mRNA processing
inhibition of host pre-mRNA processing by virus
negative regulation of host mRNA processing
suppression by virus of host mRNA processing
The series of molecular signals initiated by the binding ssRNA or dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.
DDX58 signaling pathway
retinoic acid inducible gene I signaling pathway
RIG-I signalling pathway
RIG-I-like receptor (RLR) signaling pathway
RIG-like helicase signaling pathway
RIG-like receptor signaling pathway
RLH signaling pathway
RLR signaling pathway
The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.
IFIH1 signaling pathway
MDA-5 signalling pathway
MDA5 signaling pathway
melanoma differentiation-associated gene 5 signaling pathway
Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway.
regulation of cytosolic pattern recognition receptor signaling pathway
regulation of MAV signaling
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway.
negative regulation of cytoplasmic pattern recognition receptor signaling pathway in response to virus
negative regulation of cytosolic pattern recognition receptor signaling pathway
negative regulation of MAVS signaling
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
negative regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway
Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA.
regulation of IFIH1 signaling pathway
regulation of MDA-5 signalling pathway
regulation of MDA5 signaling pathway
regulation of melanoma differentiation-associated gene 5 signaling pathway
Any process that modulates the frequency, rate or extent of the RIG-I signaling pathway.
regulation of DDX58 signaling pathway
regulation of retinoic acid inducible gene I signaling pathway
regulation of RIG-I signalling pathway
A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway. This is a mechanism by which the virus evades the host innate immune response.
suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus
suppression by virus of host RIG-I-like receptor (RLR) signaling pathway
suppression by virus of host RIG-I/MDA5 signaling pathway
suppression by virus of host RIG-like helicase signaling pathway
suppression by virus of host RIG-like receptor signaling pathway
suppression by virus of host RLR signaling pathway
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway
A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.
disruption by virus of host JAK-STAT cascade via inhibition of STAT activity
inhibition by virus of host STAT activity
suppression by virus of host JAK-STAT cascade via inhibition of STAT activity
suppression by virus of host signal transducer and activator of transcription activity
suppression by virus of host STAT activity
A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC protein complex.
suppression by virus of host antigen processing and presentation
A process in which a symbiont inhibits or disrupts the translation of host mRNA into protein, for example by cleavage of the host mRNAs. The host is defined as the larger of the organisms involved in a symbiotic interaction.
host mRNA cleavage by viral endoribonuclease
host translation shutoff
host translation shutoff by virus
suppression by virus of host translation
viral host shutoff protein
viral inhibition of cellular protein synthesis
viral shutoff of host protein synthesis
A process in which a symbiont inhibits or disrupts transcription of genes into mRNA in its host. For example, symbiont proteins can interfere with host RNA polymerase or with transcription factors. The host is defined as the larger of the organisms involved in a symbiotic interaction.
host transcription shut-off
host transcription shutoff by virus
suppression by virus of host DNA-dependent transcription
suppression by virus of host transcription
Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell.
fusion of virus membrane with host endosomal membrane
viral entry into host cell via caveolae-mediated endocytosis followed by membrane fusion with the endosome membrane
viral entry into host cell via caveolin-mediated endocytosis followed by membrane fusion with the endosome membrane
viral entry into host cell via clathrin-mediated endocytosis followed by membrane fusion with the endosome membrane
viral entry into host cell via endocytosis followed by membrane fusion with host endosome
viral entry into host cell via endocytosis followed by membrane fusion with the endosome membrane
viral penetration via endocytosis followed by caveolae-mediated membrane fusion with the endosome membrane
viral penetration via endocytosis followed by clathrin-mediated membrane fusion with the endosome membrane
A process in which a symbiont alters or subverts the normal execution of host gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. The host is defined as the larger of the organisms involved in a symbiotic interaction.
modulation by virus of host gene expression
regulation by virus of host gene expression
A process in which a symbiont inhibits or disrupts expression of genes in its host. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. The host is defined as the larger of the organisms involved in a symbiotic interaction.
host gene expression shutoff
host gene expression shutoff by virus
suppression by virus of host gene expression
Merging of the virion membrane and a host membrane (host plasma membrane or host organelle membrane) that is involved in the uptake of a virus into a host cell.
fusion of virus membrane with host membrane
fusion of virus membrane with host membrane during viral entry
viral entry into host cell via membrane fusion
The viral-induced lysis of an organelle (endosome, lysosome, or caveosome) that is involved in the uptake of a virus into a host cell. Occurs once the virus is within the organelle, and results in transfer of the viral contents from the organelle compartment into the cytoplasm.
viral entry into host cell via endosome membrane lysis
viral entry into host cell via lysis of host organelle membrane
viral membrane-lytic protein
viral penetration via lysis of host organellar membrane
Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm.
viral entry into host cell via permeabilization of host organelle membrane
viral membrane-penetration protein
viral penetration via host endosomal membrane disruption by virus
viral penetration via perforation of host organellar membrane by virus
viral penetration via permeabilization of host organellar membrane
Any process by which a virus avoids the effects mediated by the host organism's natural killer (NK) cells.
evasion by virus of host natural killer cell response
evasion by virus of host NK cell killing
modulation of host NK-cell activity by virus
protection by virus against host NK cell cytotoxicity
suppression by virus of host natural killer cell function
viral immunoevasion of host NK cell
Entry of a symbiont's genome into the host cell through the host cell envelope. Occurs in non-enveloped prokaryotic viruses. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm.
phage genome ejection
viral genome ejection through host cell envelope
viral genome injection through bacterial membranes
A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II.
retroviral genome replication
viral ssRNA replication via dsDNA intermediate
The replication of a viral DNA genome.
DNA-dependent viral DNA replication
viral DNA replication
viral DNA-dependent DNA replication
Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process.
host-assisted viral budding
viral budding through the ESCRT machinery
An intracellular compartment in a host cell which increases the efficiency of viral replication, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments.
virus factory
A cytoplasmic viral factory that consists of a double-membrane bound vesicle. Has a diameter of 200-300nm and is derived from the endoplasmic reticulum or Golgi apparatus. Produced by Picornaviridae, Nidovirales, Arteriviridae and Coronaviridae.
DMV viral factory
The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs.
establishment of mitotic spindle localisation
mitotic spindle positioning
mitotic spindle positioning and orientation
mitotic spindle positioning or orientation
spindle positioning during mitosis
spindle positioning involved in mitotic cell cycle
Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans.
collagen and cuticulin-based cuticle anabolism
collagen and cuticulin-based cuticle biosynthetic process
collagen and cuticulin-based cuticle formation
collagen and cuticulin-based cuticle synthesis
Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster.
chitin-based cuticle anabolism
chitin-based cuticle biosynthetic process
chitin-based cuticle formation
chitin-based cuticle synthesis
The increase in size or mass of an entire organism, a part of an organism or a cell.
growth pattern
non-developmental growth
Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.
down regulation of locomotion
down-regulation of locomotion
downregulation of locomotion
inhibition of locomotion
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
regulation of body growth
regulation of body size
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
activation of locomotion
stimulation of locomotion
up regulation of locomotion
up-regulation of locomotion
upregulation of locomotion
Any process that activates or increases the frequency, rate or extent of embryonic development.
activation of embryonic development
stimulation of embryonic development
up regulation of embryonic development
up-regulation of embryonic development
upregulation of embryonic development
Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.
regulation of meiosis
A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal.
regulation of gene expression, epigenetic
Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.
developmental timing
heterochronic regulation of development
temporal regulation of development
Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
regulation of FGF receptor signaling pathway
regulation of FGF receptor signalling pathway
regulation of FGFR signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
down regulation of fibroblast growth factor receptor signaling pathway
down-regulation of fibroblast growth factor receptor signaling pathway
downregulation of fibroblast growth factor receptor signaling pathway
inhibition of fibroblast growth factor receptor signaling pathway
negative regulation of FGF receptor signaling pathway
negative regulation of FGF receptor signalling pathway
negative regulation of FGFR signaling pathway
The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
translocation of peptides or proteins into other organism during symbiotic interaction
translocation of peptides or proteins into other organism involved in symbiotic interaction
transport of peptides or proteins into host
transport of peptides or proteins into other organism during symbiotic interaction
Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.
DNA endoreplication
DNA re-duplication
The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
heat shock protein activity
Binds to and stops, prevents or reduces an ATP hydrolysis activity.
adenosinetriphosphatase inhibitor