NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.
D-phosphoglycerate 2,3-phosphomutase activity
PGA mutase activity
PGAM activity
PGM
phosphoglycerate phosphomutase activity
phosphoglyceromutase activity
Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.
cytosolic phospholipase A2 activity
lecithinase A activity
phosphatidase activity
phosphatidolipase activity
phosphatidylcholine 2-acylhydrolase activity
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
secreted phospholipase A2 activity
Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
phosphatidase C
Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate.
choline phosphatase activity
lecithinase D activity
lipophosphodiesterase II activity
phosphatidylcholine phosphatidohydrolase activity
Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate.
1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity
1,4-alpha-glucan phosphorylase activity
alpha-glucan phosphorylase
amylopectin phosphorylase
amylophosphorylase activity
glucan phosphorylase
glucosan phosphorylase
granulose phosphorylase
muscle phosphorylase
muscle phosphorylase a and b activity
myophosphorylase
polyphosphorylase activity
potato phosphorylase
starch phosphorylase
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
protein-cysteine geranylgeranyltransferase activity
Catalysis of the reaction: H2O + L-arginyl- = L-citrullyl- + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent.
peptidylarginine deiminase activity
protein-L-arginine iminohydrolase activity
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protamine kinase activity
Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
ATP:protein-L-histidine N-phosphotransferase activity
histidine kinase activity
histidine protein kinase activity
protein kinase (histidine)
protein-histidine kinase activity
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity
protein serine-threonine kinase activity
protein threonine kinase activity
protein-serine kinase activity
serine kinase activity
serine protein kinase activity
serine(threonine) protein kinase activity
serine-specific protein kinase activity
serine/threonine protein kinase activity
threonine-specific protein kinase activity
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
receptor protein serine/threonine kinase activity
receptor serine/threonine protein kinase activity
Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. This activity require the presence of calcium-bound calmodulin.
ATP:caldesmon O-phosphotransferase activity
ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity
Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity
Ca2+/calmodulin-dependent protein kinase 1 activity
Ca2+/calmodulin-dependent protein kinase activity
Ca2+/calmodulin-dependent protein kinase II activity
Ca2+/calmodulin-dependent protein kinase IV activity
Ca2+/calmodulin-dependent protein kinase kinase activity
Ca2+/calmodulin-dependent protein kinase kinase beta activity
Ca2+/CaM-dependent kinase activity
calcium- and calmodulin-dependent protein kinase activity
calcium/calmodulin-dependent protein kinase type II activity
caldesmon kinase (phosphorylating) activity
calmodulin regulated protein kinase activity
calmodulin-dependent kinase II activity
calmodulin-dependent protein kinase activity
calmodulin-dependent protein kinase I activity
CaM kinase activity
CaM kinase II activity
CAM PKII
CaM-regulated serine/threonine kinase activity
CaMKI
CaMKII
CaMKIV
CaMKKalpha
CaMKKbeta
microtubule-associated protein 2 kinase activity
multifunctional calcium- and calmodulin-regulated protein kinase activity
multifunctional calcium/calmodulin regulated protein kinase activity
STK20
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
ATP:protein phosphotransferase (diacylglycerol-dependent) activity
cPKC
cPKCalpha
cPKCbeta
cPKCgamma
diacylglycerol-activated phospholipid-dependent PKC activity
diacylglycerol-activated phospholipid-dependent protein kinase C activity
nPKC
nPKCdelta
nPKCepsilon
nPKCeta
nPKCtheta
PKC
PKC activity
Pkc1p
PKCalpha
PKCbeta
PKCdelta
PKCepsilon
PKCgamma
protein kinase Cepsilon activity
STK24
Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate.
ATP:G-protein-coupled receptor phosphotransferase activity
G protein coupled receptor phosphorylating protein kinase activity
G-protein coupled receptor kinase activity
G-protein-coupled receptor phosphorylating protein kinase activity
GPCR kinase activity
GPCR phosphorylating protein kinase activity
GPCRK
GRK4
GRK5
GRK6
STK16
Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
ATP:protein phosphotransferase (MAPKK-activated) activity
ERK
ERK1
ERK2
extracellular signal-regulated kinase activity
MAP kinase 1 activity
MAP kinase 2 activity
MAPK
MBP kinase I activity
MBP kinase II activity
mitogen activated kinase activity
mitogen-activated protein kinase activity
myelin basic protein kinase activity
SAP kinase activity
SAPK
stress-activated kinase activity
stress-activated protein kinase activity
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a T-X-Y motif in the activation loop of a MAP kinase (MAPK) substrate.
ATP:protein phosphotransferase (MAPKKK-activated) activity
ERK activator kinase activity
MAP kinase kinase 4 activity
MAP kinase kinase 7 activity
MAP kinase or ERK kinase activity
MAP2K
MAPK activator activity
MAPKK
MAPKK activity
MAPKK1
MEK activity
MEK1
MEK2
mitogen-activated protein kinase kinase activity
MKK
MKK2
MKK4
MKK6
MKK7
STK27
Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
ATP:protein phosphotransferase (MAPKKKK-activated) activity
cMos
cRaf
MAP3K
MAPK/ERK kinase kinase activity
MAPKKK activity
MEK kinase activity
MEKK
MEKK activity
MEKK1
MEKK2
MEKK3
Mil/Raf
mitogen-activated protein kinase kinase kinase activity
MLK-like mitogen-activated protein triple kinase activity
MLTK
MLTKa
MLTKb
REKS
STK28
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
dual-specificity kinase activity
dual-specificity protein kinase
protein threonine/tyrosine kinase activity
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein-tyrosine kinase activity
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
receptor protein tyrosine kinase activity
receptor protein-tyrosine kinase activity
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
phosphoprotein phosphohydrolase activity
protein phosphatase activity
protein phosphatase-1 activity
protein phosphatase-2A activity
protein phosphatase-2B activity
protein phosphatase-2C activity
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
magnesium-dependent protein serine/threonine phosphatase activity
phosphatase I
phosphatase II
phosphatase III
protein phosphatase type 1 activity
protein phosphatase type 2A activity
protein phosphatase type 2B activity
protein phosphatase type 2C activity
protein phosphatase-1
protein phosphatase-2A
protein phosphatase-2B
protein phosphatase-2C
protein serine phosphatase activity
protein threonine phosphatase activity
serine/threonine specific protein phosphatase activity
Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions.
calcineurin
calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
protein phosphatase activity
phosphoprotein phosphatase (phosphotyrosine) activity
phosphotyrosine histone phosphatase activity
phosphotyrosine phosphatase activity
phosphotyrosine protein phosphatase activity
phosphotyrosylprotein phosphatase activity
PPT-phosphatase activity
protein phosphotyrosine phosphatase activity
protein-tyrosine-phosphatase activity
protein-tyrosine-phosphate phosphohydrolase activity
PTP-phosphatase activity
PTPase activity
tyrosine O-phosphate phosphatase activity
tyrosylprotein phosphatase activity
Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
inosine phosphorylase activity
inosine-guanosine phosphorylase activity
PNPase activity
PUNPI
PUNPII
purine deoxynucleoside phosphorylase activity
purine deoxyribonucleoside phosphorylase activity
purine nucleoside phosphorylase activity
purine ribonucleoside phosphorylase activity
purine-nucleoside:phosphate ribosyltransferase activity
Catalysis of the oxidative decarboxylation of pyruvate.
pyruvic acid dehydrogenase activity
pyruvic dehydrogenase activity
Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
2\'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2\'-oxidoreductase activity
2\'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2\'-oxidoreductase activity
Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor.
lysine-2-oxoglutarate reductase activity
lysine-ketoglutarate reductase activity
Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+.
sphingomyelin cholinephosphohydrolase activity
sphingomyelinase activity
Catalysis of the reaction: a long-chain fatty acyl-CoA + a sterol = a sterol ester + CoA.
sterol-ester synthase activity
sterol-ester synthetase activity
Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate.
sulphate adenylyltransferase activity
Catalysis of the reaction: L-threonine = glycine + acetaldehyde.
L-threonine acetaldehyde-lyase (glycine-forming)
L-threonine acetaldehyde-lyase activity
L-threonine aldolase activity
Catalysis of the reaction: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+.
amano AP
amano B
amano CE
amano CES
amano P
amno N-AP
butyrinase activity
cacordase activity
capalase L
GA 56
GEH
glycerol ester hydrolase activity
glycerol-ester hydrolase activity
heparin releasable hepatic lipase
hepatic lipase
hepatic monoacylglycerol acyltransferase
lipazin
liver lipase
meito MY 30
meito sangyo OF lipase
post-heparin plasma protamine-resistant lipase
PPL
salt-resistant post-heparin lipase
steapsin
TAG activity
takedo 1969-4-9
triacetinase activity
triacylglycerol acylhydrolase activity
triacylglycerol ester hydrolase activity
tributyrase activity
tributyrin esterase activity
tributyrinase activity
triglyceridase activity
triglyceride hydrolase activity
triglyceride lipase activity
triolein hydrolase activity
tween hydrolase activity
tween-hydrolyzing esterase activity
tweenase activity
tweenesterase activity
Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate.
ATP(CTP)-tRNA nucleotidyltransferase
ATP(CTP):tRNA nucleotidyltransferase activity
CCA-adding enzyme activity
CTP(ATP):tRNA nucleotidyltransferase
CTP:tRNA cytidylyltransferase activity
ribonucleic cytidylic cytidylic adenylic pyrophosphorylase
ribonucleic cytidylyltransferase
transfer ribonucleate adenyltransferase activity
transfer ribonucleate adenylyltransferase
transfer ribonucleate nucleotidyltransferase
transfer ribonucleic acid nucleotidyl transferase
transfer ribonucleic adenylyl (cytidylyl) transferase
transfer ribonucleic-terminal trinucleotide nucleotidyltransferase
transfer RNA adenylyltransferase
transfer-RNA nucleotidyltransferase
tRNA adenylyl(cytidylyl)transferase
tRNA CCA-diphosphorylase activity
tRNA cytidylyltransferase activity
tRNA-nucleotidyltransferase activity
Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.
aminoacyl-tRNA synthetase activity
aminoacyl-tRNA synthetase auxiliary protein activity
ligase activity, forming aminoacyl-tRNA and related compounds
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
E2
E3
ubiquitin conjugating enzyme activity
ubiquitin ligase activity
ubiquitin protein ligase activity
ubiquitin protein-ligase activity
ubiquitin-conjugating enzyme activity
An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
deubiquitinase
deubiquitinase activity
deubiquitinating enzyme
deubiquitylase
thiol-dependent deubiquitinase
thiol-dependent ubiquitin-specific protease activity
thiol-dependent ubiquitinyl hydrolase activity
ubiquitin C-terminal hydrolase
ubiquitin hydrolase activity
ubiquitin-specific protease activity
ubiquitinyl hydrolase 1 activity
ubiquitinyl hydrolase activity
UBP
UCH2
Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.
uracil-DNA glycosylase activity
Binds to and stops, prevents or reduces the activity of an enzyme.
metalloenzyme inhibitor activity
Binds to and stops, prevents or reduces the activity of a protein phosphatase.
phosphoprotein phosphatase inhibitor activity
protein phosphatase 2 inhibitor activity
protein phosphatase type 2A inhibitor activity
Binds to and stops, prevents or reduces the activity of an endopeptidase.
alpha-2 macroglobulin
endoproteinase inhibitor
proteinase inhibitor
Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase.
cystatin
cysteine protease inhibitor activity
thiol protease inhibitor
Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
anaphylatoxin receptor activity
A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.
1,25-(OH)2D3 receptor activity
9-cis retinoic acid receptor activity
androgen receptor activity
calcitriol receptor activity
ecdysteroid hormone receptor activity
estrogen nuclear receptor activity
glucocorticoid receptor activity
juvenile hormone receptor activity
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
ligand-dependent nuclear receptor activity
ligand-dependent transcription factor activity
nuclear hormone receptor
retinoic acid receptor activity
retinoid-X receptor activity
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
RXR
thyroid hormone receptor activity
vitamin A receptor activity
vitamin D receptor activity
vitamin D3 receptor activity
Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function.
glucocorticoid receptor activity
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
transmembrane receptor activity
transmembrane signalling receptor activity
Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
hematopoietin/interferon-class (D200-domain) cytokine receptor activity
IL receptor
interleukin receptor activity
Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
CNTF receptor activity
gp130
Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
IFN receptor activity
Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
IL-1 receptor activity
IL-1R
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
EBV-induced receptor
Epstein-Barr Virus-induced receptor activity
G protein coupled receptor activity
G protein linked receptor activity
G-protein coupled receptor activity
G-protein coupled receptor activity, unknown ligand
G-protein linked receptor activity
GPCR activity
ligand-dependent GPCR activity
Mas proto-oncogene receptor activity
orphan G protein coupled receptor activity
orphan G-protein coupled receptor activity
orphan GPCR activity
RDC1 receptor activity
receptor activity, G-protein coupled
SREB receptor
super conserved receptor expressed in brain receptor activity
Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex.
adrenoceptor activity
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors.
alpha adrenoceptor
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.
beta adrenoceptor
Combining with an icosanoid to initiate a change in cell activity.
eicosanoid receptor activity
Combining with a thromboxane (TXA) to initiate a change in cell activity.
TXA receptor activity
Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
ionotropic glutamate receptor activity
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
odorant receptor activity
Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein.
opioid receptor activity
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
5-HT receptor
5-hydroxytryptamine receptor
G protein coupled serotonin receptor activity
G-protein coupled serotonin receptor activity
Combining with an ephrin receptor ligand to initiate a change in cell activity.
Eph receptor activity
Combining with platelet-derived growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
PDGF receptor activity
PDGF-activated receptor activity
PDGFR activity
platelet-derived growth factor-activated receptor activity
Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
TGF-beta receptor activity
TGFbeta receptor activity
TGFbeta-activated receptor activity
TGFbetaR
transforming growth factor beta-activated receptor activity
Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death.
apoptosis-activating receptor activity
Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.
leader sequence binding
protein signal sequence binding
signal sequence receptor
Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.
GDI
Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
receptor binding
receptor ligand
receptor-associated protein activity
Binding to a fibroblast growth factor receptor (FGFR).
FGF receptor binding
FGFR binding
FGFR ligand
fibroblast growth factor
fibroblast growth factor receptor ligand
Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
APO binding
death receptor adaptor protein activity
death receptor interacting protein activity
death receptor ligand
death receptor-associated factor activity
DR binding
EDAR binding
FAS binding
KILLER binding
NGFR binding
TNFR1 binding
TRAIL binding
The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.
autocrine activity
paracrine activity