NothingMuch/GO-Terms huggingface dataset:
The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which includes including UBF, SL1, RRN3 and TBP in human). The PIC engages RNA polymerase I on its DNA template strand and sparks polymerization of the first few RNA nucleotides.
RNA polymerase I transcriptional preinitiation complex assembly
RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nucleolar primary rRNA transcript
Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter.
maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter
maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter
Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter.
maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter
maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter
Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
RNA polymerase II transcription corepressor binding
Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
RNA polymerase II transcription coactivator binding
A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific
metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription
metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding
RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription
transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific
metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding
RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding
RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding
RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding
RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
transcriptional activator activity, metal ion regulated sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone.
base of shmoo tip
conjugation tube base
A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.
mitochondrial sorting and assembly machinery complex
TOB complex
Relaying of environmental signals promoting filamentous growth.
MAPKKK cascade (pseudohyphal growth)
signal transduction during filamentous growth
Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix.
mitochondrial import motor
PAM complex
pre-sequence translocase-associated import motor
presequence translocase-associated import motor
The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans.
chlamydospore development
The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission.
acetylcholine breakdown in synaptic cleft
acetylcholine degradation in synaptic cleft
Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.
N-ribosyldihydronicotinamide dehydrogenase (quinone) activity
NQO2
NQO2 activity
NRH:quinone oxidoreductase 2 activity
QR2 activity
quinone reductase 2 activity
ribosyldihydronicotinamide dehydrogenase (quinone) activity
Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate.
N-acetylglucosamine 6-O-sulphotransferase activity
A sodium channel in a cell membrane whose opening is governed by the membrane potential.
voltage gated sodium channel complex
voltage-dependent sodium channel complex
voltage-sensitive sodium channel complex
A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins.
outer dense fibre
Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.
extended fibrils
fibrillin
Binding to a lipopolysaccharide.
endotoxin binding
LPS binding
Binding to an interleukin-21 receptor.
IL-21
interleukin-21 receptor ligand
Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
IL-21 receptor activity
IL-21R
Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate.
N-acetylgalactosamine 4-O-sulphotransferase activity
Binding to an amyloid-beta peptide/protein.
beta-amyloid binding
Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells.
ovarian cumulus growth
Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.
interpretation of external signals that regulate cell growth
regulation of cell growth by detection of exogenous stimulus
regulation of cell growth by sensing of exogenous stimulus
regulation of growth by exogenous signal
regulation of growth by exogenous stimuli
regulation of growth by exogenous stimulus
regulation of growth by external signal
regulation of growth by external stimuli
regulation of growth by external stimulus
The series of events in which a stimulus from a protozoan is received and converted into a molecular signal.
detection of protozoa
detection of protozoon
perception of protozoa
Catalysis of the reaction: AH(2) + cholesterol + O2 = 25-hydroxycholesterol + A + H2O.
cholesterol 25-monooxygenase activity
cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity
Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity.
non-tyrosine kinase FGF receptor activity
non-tyrosine kinase FGFR activity
The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides.
lactosylceramide anabolism
lactosylceramide biosynthesis
lactosylceramide formation
lactosylceramide synthesis
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
bitter taste detection
perception of bitter taste, detection of chemical stimulus
perception of bitter taste, sensory transduction of chemical stimulus
sensory detection of bitter taste
sensory detection of chemical stimulus during perception of bitter taste
sensory transduction of bitter taste
sensory transduction of chemical stimulus during perception of bitter taste
The series of events required for a sour taste stimulus to be received and converted to a molecular signal.
perception of sour taste, detection of chemical stimulus
perception of sour taste, sensory transduction of chemical stimulus
sensory detection of chemical stimulus during perception of sour taste
sensory detection of sour taste
sensory transduction of chemical stimulus during perception of sour taste
sensory transduction of sour taste
sour taste detection
The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.
perception of sweet taste, detection of chemical stimulus
perception of sweet taste, sensory transduction of chemical stimulus
sensory detection of chemical stimulus during perception of sweet taste
sensory detection of sweet taste
sensory transduction of chemical stimulus during perception of sweet taste
sensory transduction of sweet taste
sweet taste detection
The series of events required for a salty taste stimulus to be received and converted to a molecular signal.
perception of salty taste, detection of chemical stimulus
perception of salty taste, sensory transduction of chemical stimulus
salty taste detection
sensory detection of chemical stimulus during perception of salty taste
sensory detection of salty taste
sensory transduction of chemical stimulus during perception of salty taste
sensory transduction of salty taste
Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels.
5-HT1 receptor activity
serotonin receptor activity, coupled via Gi/o
Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.
5-HT2 receptor activity
serotonin receptor activity, coupled via Gq/11
Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.
dopamine D1 receptor activity
dopamine D5 receptor activity
Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
dopamine D2 receptor activity
dopamine D3 receptor activity
dopamine D4 receptor activity
An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms.
PLC-activating angiotensin receptor activity
Combining with adrenomedullin to initiate a change in cell activity.
G10D receptor
Combining with neuromedin U to initiate a change in cell activity.
NMUR activity
Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
G protein coupled nucleotide receptor activity
G-protein coupled nucleotide receptor activity
nucleotide receptor activity, G protein coupled
nucleotide receptor activity, G-protein coupled
Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
A1 adenosine receptor activity, G protein coupled
A1 adenosine receptor activity, G-protein coupled
A2A adenosine receptor activity, G protein coupled
A2A adenosine receptor activity, G-protein coupled
A2B adenosine receptor activity, G protein coupled
A2B adenosine receptor activity, G-protein coupled
A3 adenosine receptor activity, G protein coupled
A3 adenosine receptor activity, G-protein coupled
adenosine nucleotide receptor
adenosine receptor activity, G protein coupled
adenosine receptor activity, G-protein coupled
G protein coupled A1 adenosine receptor activity
G protein coupled A2A adenosine receptor activity
G protein coupled A2B adenosine receptor activity
G protein coupled A3 adenosine receptor activity
G protein coupled adenosine receptor activity
G-protein coupled adenosine receptor activity
G-protein-coupled A1 adenosine receptor activity
G-protein-coupled A2A adenosine receptor activity
G-protein-coupled A2B adenosine receptor activity
G-protein-coupled A3 adenosine receptor activity
P1 receptor
Combining with ghrelin to initiate a change in cell activity.
ghrelin receptor activity
Combining with a virus component and mediating entry of the virus into the cell.
viral receptor activity
Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
ADP receptor activity
ADP-activated adenosine receptor activity
ADP-activated nucleotide receptor activity
K101 receptor
platelet ADP receptor activity
Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein.
nociceptin/orphanin-FQ receptor activity
OFQ receptor activity
ORPH receptor
orphanin-FQ receptor activity
X-opioid receptor activity
Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine.
CysLT receptor
Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate.
BLT receptor
A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide.
PACAP receptor
pituitary adenylate cyclase activating polypeptide receptor
pituitary adenylate cyclase activating protein receptor activity
pituitary adenylate cyclase-activating peptide receptor activity
pituitary adenylyl cyclase activating protein receptor activity
Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity.
calcitonin gene-related polypeptide receptor activity
CGRP receptor
A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system.
Group I metabotropic glutamate receptor
group I metabotropic glutamate receptor activity
phospholipase C activating metabotropic glutamate receptor activity
PLC activating G-protein coupled glutamate receptor activity
PLC activating metabotropic glutamate receptor activity
Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
3\',5\' cAMP receptor activity
3\',5\'-cAMP receptor activity
adenosine 3\',5\'-cyclophosphate receptor activity
class E G protein coupled receptor
class E G-protein coupled receptor
class E GPCR
cyclic AMP receptor activity
Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
cytokinin receptor activity, G-protein coupled
G protein coupled cytokinin receptor activity
G-protein coupled cytokinin receptor activity
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
fibrillar centre
A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.
pars fibrosa
A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.
pars granulosa
Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano--(N-acetyl-D-galactosaminyl)-glycoprotein.
GalNAc alpha-2,6-sialyltransferase I activity
Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.
tRNA 5\' leader removal
The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
histamine anabolism
histamine biosynthesis
histamine formation
histamine synthesis
The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
histamine breakdown
histamine catabolism
histamine degradation
The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.
ectoderm cell fate determination
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
actin cable
stress fibre
Catalysis of the reaction: an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H+.
acylsphingosine kinase activity
ATP:ceramide 1-phosphotransferase activity
Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
(2-5\')oligo(A) synthetase activity
2\'-5\' oligoadenylate synthetase activity
2-5A synthetase activity
oligo-2\',5\'-adenylate synthetase activity
Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
cytoplasmic translation initiation complex assembly
formation of translation initiation complex
translation initiation complex assembly
Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate.
3\'-phosphoadenosine-5\'-phosphosulfate-cerebroside sulfotransferase activity
3\'-phosphoadenylyl-sulfate:galactosylceramide 3\'-sulfotransferase activity
cerebroside sulfotransferase activity
galactocerebroside sulfotransferase activity
galactolipid sulfotransferase activity
galactosylceramide sulphotransferase activity
glycolipid sulfotransferase activity
glycosphingolipid sulfotransferase activity
GSase
Catalysis of the reaction: an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H+ + S-adenosyl-L-homocysteine. This activity is the methylation of adenines in mRNA with the consensus sequence RRACH, where R is a purine, and H is C, A, or U.
mRNA (N6-adenosine)-methyltransferase activity
Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.
prenylcysteine lyase activity
S-prenyl-L-cysteine:oxygen oxidoreductase activity