NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1).
cellulose synthetase activity
Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor).
transferase activity, transferring pentosyl groups
Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).
transferase activity, transferring alkyl or aryl groups, other than methyl groups
Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor).
transferase activity, transferring other nitrogenous groups
Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).
sulphurtransferase activity
Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor).
transferase activity, transferring selenium-containing groups
Catalysis of the hydrolysis of any ester bond.
esterase activity
Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.
thiolesterase activity
Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
phosphatase
phosphoric monoester hydrolase activity
Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5\' phosphomonoesters
Catalysis of the hydrolysis of any glycosyl bond.
glycosidase activity
glycosylase
N-glycosylase
Catalysis of the hydrolysis of a thioether bond, -S-.
thioether hydrolase activity
trialkylsulphonium hydrolase activity
Catalysis of the hydrolysis of a dipeptide.
cytosolic dipeptidase activity
Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds
Catalysis of the hydrolysis of any acid anhydride.
hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement
Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-.
hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides
Catalysis of the hydrolysis of any acid sulfur-nitrogen bond.
hydrolase activity, acting on acid sulphur-nitrogen bonds
Catalysis of the hydrolysis of any acid sulfur-sulfur bond.
hydrolase activity, acting on acid sulphur-sulphur bonds
Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
other carbon-carbon lyase activity
Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
decarboxylase activity
Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone.
aldolase activity
Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid.
oxo-acid lyase activity
oxoacid lyase activity
Catalysis of the breakage of a carbon-oxygen bond.
other carbon-oxygen lyase activity
Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99).
other carbon-nitrogen lyase activity
Catalysis of the elimination of hydrogen sulfide or substituted H2S.
carbon-sulphur lyase activity
Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
other isomerase activity
Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule.
racemase and epimerase activity, acting on other compounds
Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears.
intramolecular isomerase activity
intramolecular oxidoreductase activity, other intramolecular oxidoreductases
Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears.
intramolecular isomerase activity, interconverting aldoses and ketoses
Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears.
intramolecular isomerase activity, interconverting keto- and enol-groups
Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears.
intramolecular isomerase activity, transposing C=C bonds
Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears.
intramolecular isomerase activity, transposing S-S bonds
Catalysis of the transfer of a functional group from one position to another within a single molecule.
intramolecular transferase activity, transferring other groups
mutase activity
Catalysis of the transfer of an acyl group from one position to another within a single molecule.
intramolecular transferase activity, transferring acyl groups
Catalysis of the transfer of a phosphate group from one position to another within a single molecule.
intramolecular transferase activity, phosphotransferases
phosphomutase activity
phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers
Catalysis of the transfer of an amino group from one position to another within a single molecule.
intramolecular transferase activity, transferring amino groups
Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
synthetase activity
Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
ligase activity, forming carbon-sulphur bonds
Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
other carbon-nitrogen ligase activity
Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
amide synthase activity
Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
peptide synthase activity
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
endodeoxyribonuclease activity, producing 5\' phosphomonoesters
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters.
endodeoxyribonuclease activity, producing 3\'-phosphomonoesters
endodeoxyribonuclease activity, producing other than 5\'-phosphomonoesters
Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
endoribonuclease activity, producing 5\'-phosphomonoesters
Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters.
endoribonuclease activity, producing 3\'-phosphomonoesters
endoribonuclease activity, producing other than 5\'-phosphomonoesters
Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
5\'-endonuclease activity
endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5\'-phosphomonoesters
Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters.
3\'-endonuclease activity
endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3\'-phosphomonoesters
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.
exodeoxyribonuclease activity, producing 5\' phosphomonoesters
exonuclease VIII activity
Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.
exoribonuclease activity, producing 5\' phosphomonoesters
exoribonuclease activity, producing 5\'-phosphomonoesters
Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors
Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms.
4-aminobutanoate receptor activity
4-aminobutyrate receptor activity
GABA binding
gamma-aminobutyrate binding
gamma-aminobutyric acid binding
gamma-aminobutyric acid receptor activity
Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina.
blue-sensitive opsin
green-sensitive opsin
long-wave-sensitive opsin
opsin
red-sensitive opsin
retinaldehyde binding
short-wave-sensitive opsin
UV-sensitive opsin
violet-sensitive opsin
vitamin A binding
Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand.
ligand-dependent nuclear receptor binding
ligand-dependent nuclear receptor interactor activity
nuclear hormone receptor binding
steroid hormone receptor binding
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
protein sumolation
small ubiquitin-related protein 1 conjugation
Smt3-protein conjugation
Smt3p-protein conjugation
SUMO-protein conjugation
sumoylation
The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.
desumoylation
protein desumolation
Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
extracellular-glycine-gated ion channel activity
glycine receptor
Catalysis of the reaction: a short-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized  = a short-chain (2E)-enoyl-CoA + reduced . A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.
butanoyl-CoA dehydrogenase
butyryl dehydrogenase
short-chain acyl CoA dehydrogenase
short-chain-acyl-CoA dehydrogenase activity
unsaturated acyl-CoA reductase
A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development.
IGF binding protein complex
Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2.
sulfhydryl oxidase activity
thiol:oxygen oxidoreductase activity
The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall.
cell wall breakdown
cell wall catabolism
cell wall degradation
cellular cell wall macromolecule breakdown
cellular cell wall macromolecule catabolic process
cellular cell wall macromolecule catabolism
cellular cell wall macromolecule degradation
The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
antibiotic metabolism
The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
antibiotic anabolism
antibiotic biosynthesis
antibiotic formation
antibiotic synthesis
The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
antibiotic breakdown
antibiotic catabolism
antibiotic degradation
Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta.
activin-activated receptor activity
The covalent linkage of heme and a protein.
protein-haem linkage
The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
cytochrome biogenesis
The covalent addition of a nitric oxide group to an amino acid within a protein.
protein amino acid nitrosylation
Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.
regulation of TGF-beta receptor signaling pathway
regulation of TGFbeta receptor signaling pathway
regulation of transforming growth factor beta receptor signalling pathway
Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
myosin phosphatase myosin binding
The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
protein uptake
Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine.
cerebrosidase activity
glycosyl ceramide glycosylhydrolase activity
glycosyl-N-acylsphingosine glycohydrolase activity
Binding to a peptide with hormonal activity in animals.
polypeptide hormone binding
A protein complex that possesses activity that prevents or downregulates transcription.
cytoplasmic transcriptional repressor complex
nuclear transcriptional repressor complex
transcription factor inhibitor complex
transcriptional repressor complex
The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents.
coenzyme Q and cytochrome c reductase complex assembly
coenzyme Q and cytochrome c reductase complex biogenesis
complex III assembly
complex III biogenesis
cytochrome bc(1) complex assembly
cytochrome bc(1) complex biogenesis
Binding to a small nuclear RNA (snRNA).
base pairing with snRNA
small nuclear RNA binding
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.
insecticide resistance
insecticide susceptibility/resistance
Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid.
glycolipid carrier activity
glycolipid transporter activity
intermembrane glycolipid transfer activity
intermembrane glycolipid transporter activity
Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate.
apyrase activity
inosine 5\'-diphosphatase
inosine diphosphatase
NDPase activity
nucleoside 5\'-diphosphatase activity
nucleoside diphosphatase activity
nucleoside diphosphate phosphohydrolase activity
nucleoside-diphosphatase activity
nucleoside-diphosphate phosphohydrolase activity
type B nucleoside diphosphatase
type L nucleoside diphosphatase
Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate.
apyrase activity
NTPase activity
nucleoside 5-triphosphatase activity
nucleoside triphosphatase activity
nucleoside triphosphate hydrolase activity
nucleoside triphosphate phosphatase activity
nucleoside triphosphate phosphohydrolase activity
nucleoside-5-triphosphate phosphohydrolase activity
nucleoside-triphosphatase activity
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix.
single-stranded DNA-dependent ATP-dependent DNA helicase activity
single-stranded DNA-dependent ATPase activity
ssDNA-dependent ATP-dependent DNA helicase activity
ssDNA-dependent ATPase activity
The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).
phospholipid scrambling
PL scrambling
Catalysis of the reaction: N(6)-acetyl-L-lysyl- + NAD+ + H2O = L-lysyl- + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a histone to NAD, producing nicotinamide.
histone deacetylase activity
NAD-dependent histone deacetylase activity
NAD-dependent histone lysine deacetylase activity
SIR2
sirtuin
The chemical reactions and pathways involving insecticides, chemicals used to kill insects.
insecticide metabolism
The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.
stem cell renewal
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
down regulation of protein biosynthetic process
down-regulation of protein biosynthetic process
downregulation of protein biosynthetic process
inhibition of protein biosynthetic process
negative regulation of protein anabolism
negative regulation of protein biosynthesis
negative regulation of protein biosynthetic process
negative regulation of protein formation
negative regulation of protein synthesis
protein biosynthesis inhibitor activity
protein biosynthetic process inhibitor activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in).
sodium:dicarboxylate cotransporter activity
The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
calcium ion-dependent exocytosis
A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a C atom.
protein amino acid C-linked glycosylation
The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid.
protein adenylation
protein amino acid adenylylation
protein AMPylation
The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine.
protein S-nitrosylation
S-nitrosylation
The addition of a hydroxy group to a protein amino acid.
protein amino acid hydroxylation
The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position.
oxazole or thiazole anabolism
oxazole or thiazole biosynthesis
oxazole or thiazole formation
oxazole or thiazole synthesis
The modification of a protein amino acid by oxidation.
protein amino acid oxidation
The addition of a nucleotide to a protein amino acid.
protein amino acid nucleotidylation
The addition of phospho-uridine to a protein amino acid.
protein amino acid uridylylation
The modification of a protein amino acid by formation of an ester or amide with octanoic acid.
protein amino acid octanoylation
The addition of a carboxy group to a protein amino acid.
protein amino acid carboxylation
The modification of a protein amino acid by phosphopantetheinylation.
protein amino acid phosphopantetheinylation
The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine.
peptidyl-cysteine S-palmitoylation
peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine
peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine
peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine
peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine
The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids.
peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine
peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine
peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine
The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine.
protein amino acid O-linked glycosylation via threonine
The removal of a water group from a protein amino acid.
protein amino acid dehydration
The addition of a formyl group to a protein amino acid.
protein amino acid formylation
The removal of an amino group from a protein amino acid.
protein amino acid deamination
The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.
protein amino acid N-linked glycosylation via asparagine
A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine.
protein amino acid S-linked glycosylation