NothingMuch/GO-Terms huggingface dataset:
The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.
protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway
protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway
protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway
protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway
protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway
protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway
protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway
protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway
protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway
Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases.
ResT
TelN
Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol.
cardiolipin synthase
cardiolipin synthetase
CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity
Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol.
CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase
A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus.
nucleate RBC maturation
nucleate red blood cell maturation
Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + -glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + -glycin-2-yl radical.
-activating enzyme activity
formate acetyltransferase activating enzyme activity
formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity
formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)
formate-C-acetyltransferase-activating enzyme
PFL activase activity
PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity
pyruvate formate-lyase-activating enzyme
The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell.
CD8-positive, alpha-beta T cell fate commitment
CD8-positive, alpha-beta T lymphocyte lineage commitment
CD8-positive, alpha-beta T-cell lineage commitment
CD8-positive, alpha-beta T-lymphocyte lineage commitment
Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation.
down regulation of CD8-positive, alpha-beta T cell differentiation
down-regulation of CD8-positive, alpha-beta T cell differentiation
downregulation of CD8-positive, alpha-beta T cell differentiation
inhibition of CD8-positive, alpha-beta T cell differentiation
negative regulation of CD8-positive T lymphocyte differentiation
negative regulation of CD8-positive T-cell differentiation
negative regulation of CD8-positive T-lymphocyte differentiation
negative regulation of CD8-positive, alpha beta T lymphocyte differentiation
negative regulation of CD8-positive, alpha beta T-cell differentiation
negative regulation of CD8-positive, alpha beta T-lymphocyte differentiation
negative regulation of CD8-positive, alpha-beta T cell development
Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation.
activation of CD8-positive, alpha-beta T cell differentiation
positive regulation of CD8-positive T lymphocyte differentiation
positive regulation of CD8-positive T-cell differentiation
positive regulation of CD8-positive T-lymphocyte differentiation
positive regulation of CD8-positive, alpha beta T lymphocyte differentiation
positive regulation of CD8-positive, alpha beta T-cell differentiation
positive regulation of CD8-positive, alpha beta T-lymphocyte differentiation
positive regulation of CD8-positive, alpha-beta T cell development
stimulation of CD8-positive, alpha-beta T cell differentiation
up regulation of CD8-positive, alpha-beta T cell differentiation
up-regulation of CD8-positive, alpha-beta T cell differentiation
upregulation of CD8-positive, alpha-beta T cell differentiation
Any process that stops, prevents, or reduces the rate of memory T cell differentiation.
down regulation of memory T cell differentiation
down-regulation of memory T cell differentiation
downregulation of memory T cell differentiation
inhibition of memory T cell differentiation
negative regulation of memory T cell development
negative regulation of memory T lymphocyte differentiation
negative regulation of memory T-cell differentiation
negative regulation of memory T-lymphocyte differentiation
Any process that activates or increases the frequency, rate or extent of memory T cell differentiation.
activation of memory T cell differentiation
positive regulation of memory T cell development
positive regulation of memory T lymphocyte differentiation
positive regulation of memory T-cell differentiation
positive regulation of memory T-lymphocyte differentiation
stimulation of memory T cell differentiation
up regulation of memory T cell differentiation
up-regulation of memory T cell differentiation
upregulation of memory T cell differentiation
A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins.
pre-T lymphocyte receptor complex
pre-T-cell receptor complex
pre-T-lymphocyte receptor complex
pre-TCR complex
Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
heparin proteoglycan binding
Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA.
initiator tRNA phosphoribosyl-transferase activity
tRNA A64-2\'-O-ribosylphosphate transferase activity
Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity.
adrenocorticotropin-releasing hormone receptor activity
corticotropin-releasing factor receptor activity
CRF receptor activity
CRH receptor activity
The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.
homocysteine breakdown
homocysteine catabolism
homocysteine degradation
The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate).
2-aminobenzoate breakdown
2-aminobenzoate catabolic process
2-aminobenzoate catabolism
2-aminobenzoate degradation
anthranilate breakdown
anthranilate catabolism
anthranilate degradation
anthranilic acid catabolic process
anthranilic acid catabolism
ortho-aminobenzoic acid catabolic process
ortho-aminobenzoic acid catabolism
Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism.
Akt binding
PKB binding
Binding to a 3-phosphoinositide-dependent protein kinase.
phosphatidylinositol-3-phosphate-dependent protein kinase binding
Binding to a protein histidine kinase.
histidine kinase binding
histidine-protein kinase binding
protein-histidine kinase binding
Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.
Mrf4 binding
Myf5 binding
MyoD binding
myogenin binding
An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product.
3-hydroxypropionate cycle
3-hydroxypropionate pathway
hydroxypropionate cycle
hydroxypropionate pathway
The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH.
acetoacetic acid anabolism
acetoacetic acid biosynthesis
acetoacetic acid formation
acetoacetic acid synthesis
The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH.
acetoacetic acid breakdown
acetoacetic acid catabolism
acetoacetic acid degradation
The chemical reactions and pathways resulting in the formation of an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2.
alkyne anabolism
alkyne biosynthesis
alkyne formation
alkyne synthesis
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose.
regulation of rhamnose breakdown
regulation of rhamnose catabolism
regulation of rhamnose degradation
The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP.
L-malate fermentation
malate fermentation
malo-lactate fermentation
malolactate fermentation
The anaerobic conversion of pyrimidine nucleobases, yielding energy in the form of ATP.
pyrimidine base fermentation
pyrimidine fermentation
The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, contributing to anthocyanin accumulation in a tissue in response to a UV light stimulus.
anthocyanin biosynthesis during anthocyanin accumulation in tissues in response to UV light stimulus
anthocyanin biosynthetic process during anthocyanin accumulation in response to UV light
anthocyanin biosynthetic process during anthocyanin accumulation in tissues in response to UV light stimulus
The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesize malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.
malate aspartate shuttle
malate/aspartate shuttle
malate:aspartate shuttle
An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi.
Clr4-Rik1-Cul4 complex
CLRC ubiquitin ligase complex
Rik1 E3 ubiquitin ligase complex
Rik1-E3 ubiquitin ligase complex
Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
skeletal muscle fiber plasticity
skeletal muscle fibre plasticity
skeletal myofiber plasticity
skeletal myofibre plasticity
A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3).
CenH3 containing nucleosome
CENP-S-T-W-X
centromere specific nucleosome
centromere-specific nucleosome
centromeric nucleosome
CNP-T-W-S-X complex
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
positive regulation of JUNK activity
stimulation of JNK activity
up regulation of JNK activity
up-regulation of JNK activity
upregulation of JNK activity
Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
down regulation of JNK activity
down-regulation of JNK activity
downregulation of JNK activity
inhibition of JNK activity
negative regulation of JUNK activity
A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.
IL-12 complex
IL12A
IL12B
p35
p40
Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.
leucine zipper binding
Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester.
adenosine 5\' monophosphoramidase activity
adenosine 5\'-monophosphoramidate hydrolase activity
Binding to ADP, adenosine 5'-diphosphate.
adenosine 5\'-diphosphate binding
adenosine diphosphate binding
Binding to inositol 1,3,4,5 tetrakisphosphate.
InsP4 binding
IP4 binding
A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex
Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.
Moco binding
Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.
insulin receptor substrate  binding
IRS  binding
IRS binding
Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK.
Ku70:Ku80 heterodimer
Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.
activation of insulin-like growth factor receptor signaling pathway
positive regulation of IGF receptor signaling pathway
positive regulation of IGF receptor signalling pathway
positive regulation of insulin-like growth factor receptor signalling pathway
stimulation of insulin-like growth factor receptor signaling pathway
up regulation of insulin-like growth factor receptor signaling pathway
up-regulation of insulin-like growth factor receptor signaling pathway
upregulation of insulin-like growth factor receptor signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.
down regulation of insulin-like growth factor receptor signaling pathway
down-regulation of insulin-like growth factor receptor signaling pathway
downregulation of insulin-like growth factor receptor signaling pathway
inhibition of insulin-like growth factor receptor signaling pathway
negative regulation of IGF receptor signaling pathway
negative regulation of IGF receptor signalling pathway
negative regulation of insulin-like growth factor receptor signalling pathway
Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences.
CRISPR element metabolic process
CRISPR element metabolism
maintenance of clustered regularly interspaced short palindromic repeat elements
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored.
elaioplast organisation
elaioplast organization and biogenesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi.
periplasmic space organisation
periplasmic space organization and biogenesis
The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).
nasus morphogenesis
The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid.
epispore
exospore
perispore
A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species.
cytoplasmic clamp loader
cytoplasmic RFC
The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid.
nitrate disassimilation
nitrate dissimilation
Any process that modulates the frequency, rate or extent of carbohydrate utilization.
regulation of sugar utilization
The chemical reactions and pathways resulting in the breakdown of isoprene, C5H8.
2-methyl-1,3-butadiene catabolic process
2-methyl-1,3-butadiene catabolism
hemiterpene catabolic process
hemiterpene catabolism
A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.
multifactor translation initiation factor (eIF) complex
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.
cortical microtubule cytoskeleton organization
cortical microtubule organisation
cortical microtubule organization and biogenesis
A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair.
delta-DNA polymerase complex
A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
PCNA homotrimer
proliferating cell nuclear antigen complex
sliding clamp
The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar.
1-methylnaphthalene catabolic process
1-methylnaphthalene catabolism
1-MN catabolic process
1-MN catabolism
2-methylnaphthalene catabolic process
2-methylnaphthalene catabolism
2-MN catabolic process
2-MN catabolism
The chemical reactions and pathways resulting in the breakdown of bisphenol A, 4,4'-(propane-2,2-diyl)diphenol, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins.
bisphenol-A catabolic process
bisphenol-A catabolism
The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol.
benzoate breakdown via hydroxylation
benzoate degradation via hydroxylation
The chemical reactions and pathways resulting in the formation of tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).
tetracyclin biosynthesis
tetracyclin biosynthetic process
The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
linoleic acid metabolism
The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form.
mitochondrial fission during apoptosis
mitochondrial fragmentation involved in apoptosis
The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis.
detection of apoptotic cell
detection of apoptotic cell corpse
detection of cell corpse
recognition of apoptotic cell corpse
recognition of cell corpse
The inner layer of the ectexine.
nexine 1
A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella).
sexine 1
The layer of sexine which forms a roof over the columella, granules or other infratectal elements.
sexine 2
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out).
copper exporting ATPase activity
copper transmembrane transporter activity, phosphorylative mechanism
copper-exporting ATPase activity
copper-translocating P-type ATPase activity
copper-transporting ATPase activity
Cu(2+)-exporting ATPase activity
Cu2+-exporting ATPase activity
A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s).
T4SS complex
type IV protein secretion system complex
A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance.
reflecting platelet
A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast.
refractosome
The chemical reactions and pathways involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups.
cyanophycin metabolism
multi-L-arginyl-poly(L-aspartic acid) metabolism