NothingMuch/GO-Terms huggingface dataset:
Any process that modulates the frequency, rate or extent of a Frizzled Nuclear Import pathway.
regulation of FNI
regulation of Frizzled Nuclear Import Wnt Pathway
Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone).
histone carrier activity
nucleosome remodeling activity
The compaction of chromatin into a conformation that is refractory to transcription but that can be converted to euchromatin and allow transcription in specific contexts. These can be temporal (e.g., developmental states or specific cell-cycle stages), spatial (e.g., nuclear localization changes from the center to the periphery or vice versa due to exogenous factors/signals), or parental/heritable (e.g., monoallelic gene expression). In metazoa, this involves the methylation of histone H3K27.
facultative heterochromatin assembly
fHC assembly
The compaction of chromatin into heterochromatin, a conformation that is refractory to transcription. Constitutive heterochromatin cannot be converted back to euchromatin, the transcriptionally-active conformation. In metazoa, this involves the methylation of histone H3K9.
constitutive heterochromatin assembly
The chemical reactions and pathways resulting in the formation of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria.
patulin anabolism
patulin biosynthesis
patulin formation
patulin synthesis
The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor.
AREG production
Any process that modulates the frequency, rate, or extent of production of amphiregulin.
regulation of AREG production
The chemical reactions and pathways resulting in the formation of lovastatin (also known as mevinolin, mevacor or monacolin K), a hypolipidemic inhibitor of (3S)-hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR).
lovastatin anabolism
lovastatin biosynthesis
lovastatin formation
lovastatin synthesis
mevacor anabolism
mevacor biosynthesis
mevacor biosynthetic process
mevacor formation
mevacor synthesis
mevinolin anabolism
mevinolin biosynthesis
mevinolin biosynthetic process
mevinolin formation,
mevinolin synthesis
monacolin K anabolism
monacolin K biosynthesis
monacolin K biosynthetic process
monacolin K formation
monacolin K synthesis
A chromatin remodeler activity that slides core histone octamers along chromosomal DNA.
histone octamer sliding activity
A post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) elicit silencing of specific target genes. siRNAs are 21-23 nucleotide RNA duplexes that are fully complementary to their target mRNA. siRNAs can be exported and act in other cells, including in germline cells. Once incorporated into a RNA-induced silencing complex (RISC), siRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the mRNA or mRNA translational repression. siRNAs are present in lower animals and plants, but not found in mammals; whereas miRNAs are present in all the animals and in plants.
gene silencing by siRNA
post-transcriptional gene silencing by siRNA
posttranscriptional gene silencing by siRNA
siRNA-mediated gene silencing
siRNA-mediated PTGS
An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity.
protein substrate chaperone activity
protein-substrate adaptor activity
A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex.
protein unfoldase activity
Binding to and responding, e.g. by conformational change, to changes in the cellular level of an amino acid.
amino acid sensing activity
Catalysis of the reaction: H2O + histone 3 L-arginyl = histone 3 L-citrullyl + NH4+, resulting in histone citrullination.
histone citrullination
histone-arginine deiminase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out).
solute:metal cation antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(in) + HCO3-(out) = solute(out) + HCO3-(in).
bicarbonate:anion antiporter activity
hydrogencarbonate:monoatomic anion antiporter activity
The chemical reactions and pathways resulting in the formation of terrein, a fungal metabolite with ecological, antimicrobial, antiproliferative, and antioxidative activities.
terrein anabolism
terrein biosynthesis
terrein formation
terrein synthesis
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interferon-mediated signaling in the host organism.
inhibition of host interferon signaling pathway by symbiont
negative regulation by virus of host interferon-mediated signaling pathway
suppression by symbiont of host IFN-mediated signaling pathway
suppression by symbiont of host interferon-mediated signalling pathway
suppression by virus of host interferon-mediated signaling pathway
The series of molecular signals initiated by type II interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type II interferon is also known as interferon-gamma.
interferon signaling pathway
interferon-activated signaling pathway
The series of molecular signals initiated by a ligand binding to an endolysosomal pattern recognition receptor (PRR) of the toll-like family. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
endolysosomal pattern recognition receptor signaling pathway
The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR) of the toll-like family.
cell surface TLR signaling pathway
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + HCO3-(out) = chloride(out) + HCO3-(in).
bicarbonate:chloride antiporter activity
chloride:hydrogencarbonate antiporter activity
A deubiquitinase that cleaves ubiquitin from a histone protein to which it is conjugated.
histone deubiquitination
A histone deubiquitinase that cleaves ubiquitin from a histone H2B protein to which it is conjugated.
histone H2B deubiquitination
Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue.
histone H3 methylase activity
histone H3 methylation
Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue.
histone H4 methylase activity
histone H4 methylation
Catalysis of the reaction: S-adenosyl-L-methionine + a histone H2 = S-adenosyl-L-homocysteine + a methylated histone H2A. Histone methylation generally occurs on either an arginine or a lysine residue.
histone H2A methylase activity
histone H2A methylation
Any process carried out at the cellular level that reduces or removes the toxicity of a metal ion.
cellular detoxification of metal cation
A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.
multicellular organism level chemical homeostasis
organismal level chemical homeostasis
The formation of heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a Piwi-associated RNA (piRNA).
piRNA-directed heterochromatin formation
piwiRNA-directed heterochromatin formation
The disruption of a cellular component of another organism, leading to damage or temporary subversion of that structure. In some cases this can cause malfunctioning of the cells and death of the target organism.
disruption of cellular component of another organism
A catalytic activity that acts on the RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS). Reversible modifications cof the RNA polymerase II CTD repeats contribute to regulation of RNA polymerase activity.
RNA polymerase II CTD repeat modifying activity
RNA polymerase II large subunit CTD heptapeptide repeat modifying activity
A transposable element silencing mechanism involving heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription.
retrotransposon silencing by heterochromatin formation
A transposable element silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation.
post-transcriptional retrotransposon silencing
retrotransposon silencing by mRNA destabilization
The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction.
disruption by symbiont of actin cytoskeleton
modification by symbiont of host actin cytoskeleton
perturbation by symbiont of host actin cytoskeleton
A process by which a symbiont avoids recognition by host's innate immune response by altering, concealing or destroying a conserved symbiont molecule recognized by the host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
evasion of host innate immune recognition
evasion of host innate immune response
A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another molecule (for example a protein or a lipid) where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.
covalent modifier
tag
The disruption of a tissue of another organism, leading to damage or temporary subversion of that tissue.
tissue necrosis in another organism
A homeostatic process involved in the maintenance of a steady state level of nitrogen within a cell.
cellular nitrogen homeostasis
nitrogen homeostasis
An intracellular signal transduction pathway that starts with a ligand binding to a pattern recognition receptor (PRR), assembly of the inflammasome complex, leading to the activation of CASP1 and inducing an inflammatory response. In some cases, inflammasome-mediated signal transduction can lead to programmed cell death, such as pyroptosis.
inflammasome-mediated signal transduction
Any process that modulates the frequency, rate or extent of an inflammasome-mediated signaling pathway.
regulation of inflammasome-mediated signal transduction
Any process that stops, prevents or reduces the frequency, rate or extent of an inflammasome-mediated signaling pathway.
negative regulation of inflammasome-mediated signal transduction
Any process that activates or increases the frequency, rate or extent of an inflammasome-mediated signaling pathway.
positive regulation of inflammasome-mediated signal transduction
A process in which a symbiont initiates, promotes, or enhances the activation of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
induction of host autophagy
positive regulation by symbiont of host autophagy
The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription.
TGF-beta receptor superfamily signaling pathway
TGF-beta receptor superfamily signalling pathway
TGFbeta receptor superfamily signaling pathway
TGFbeta receptor superfamily signalling pathway
transforming growth factor beta receptor superfamily signalling pathway
An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways.
intracellular signaling cascade
intracellular signaling module
An epigenetic process that increases gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA demethylation.
activation of gene expression, epigenetic
up regulation of gene expression, epigenetic
up-regulation of gene expression, epigenetic
upregulation of gene expression, epigenetic
The process in which an organism effects a change that impairs the structure or function of a host tissue. This can occur via the disruption of the extracellular matrix, or the detachment of cells from the extracellular matrix, or the dissociation of the cells composing that tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.
cytopathogenic effect
An intracellular signaling cassette that starts with production of cyclic AMP (cAMP) by adenylate cyclase (either transmembrane or soluble), which activates protein kinase A, and ends with activation of downstream effectors such as the transcription factor CREB that further transmit the signal within the cell.
cAMP signaling
cAMP/PKA signaling cassette
PKA signaling
protein kinase A signaling
Any process that modulates the frequency, rate or extent of cAMP/PKA signal transduction.
regulation of cAMP/PKA signaling
A process that chemically modifies 5-methylcytosine (5meC) to make it a substrate for the base excision repair pathway, which then restores the unmodified cytosine.
epigenetic 5-methylcytosine DNA demethylation
epigenetic 5-methylcytosine DNA demethylation pathway
epigenetic DNA demethylation
An epigenetic cytosine DNA demethylation pathway that involves a DNA glycosylase that directly excises 5-methylcytosine (5-meC) to initiate its replacement with unmethylated cytosine through base excision repair. This pathway is known to occur in plants. In addition to CG sites, plants also methylate cytosines within CHH and CNG sequences.
epigenetic 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway
The process in which a symbiont effects a change that impairs the structure or function of a host membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated disruption of host membrane
A process by which a symbiont mitigates the effects of recognition by a host innate immune effector. Effectors have a direct activity against a symbiont and include complement, antimicrobial peptides, and bacterial restriction enzymes. The host is defined as the larger of the organisms involved in a symbiotic interaction.
evasion of symbiont recognition by host innate immune effector
The series of molecular signals initiated by a signaling molecule binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
nuclear receptor signaling pathway
A inflammatory cell death process associated with the generation of pyrogenic mediators that result from the activation of gasdermins.
pyroptosis
An intracellular signaling cassette that starts with activation of phospholipase C (PLC) activity and ends with the activation of protein kinase C (PKC). PLC produces inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors. This cassette is often part of the phospholipase C-activating G protein-coupled receptor signaling pathway.
PLC/PKC signaling
PLC/PKC/PKD signaling
Removal of an acyl group from a protein via transfer of the acyl group to NAD+, producing nicotinamide.
protein lysine deacylase activity
Catalysis of the reaction: H2O + N6-acetyl-L-lysyl- = acetate + L-lysyl-.
histone deacetylase activity
histone deacetylase activity, NAD-independent
Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches.
regulation of neurite arborization
regulation of neurite branching
regulation of neuron projection branching
That part of an axon close to and including the growth cone or the axon terminus.
distal part of axon
distal part of the axon
The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways.
optic pathway development
visual pathway development
The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents.
nerve tissue inflammatory response
nervous tissue inflammatory response
neural tissue inflammatory response
A single axon terminal bouton making contact onto two or more dendritic spines protruding either from a single dendrite or from multiple dendrites.
MSB
multi-synapse
multi-synapse bouton
multi-synaptic bouton
multiple spine synapse bouton
multiple synapse
multiple-synapse bouton
multisynapse
multisynapse bouton
multisynaptic bouton
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and one or more dendritic spines.
multi-synapse organisation
multi-synapse organization
multi-synaptic organisation
multi-synaptic organization
multiple spine synapse organisation
multisynapse organisation
multisynapse organization
multisynaptic organisation
multisynaptic organization
Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum.
glia-neuron signaling
glia-neuron signalling
glia-neurone signaling
glia-neurone signalling
glial cell- neuron signalling
glial cell-neurone signalling
glial cell-neurone singaling
The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier.
transport across BBB
transport across blood brain barrier
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction.
negative regulation of protein localisation to cell-cell junction
Any process that modulates the frequency, rate or extent of interleukin-33 production.
regulation of interleukin-33 biosynthetic process
regulation of interleukin-33 secretion
Any process that modulates the frequency, rate or extent of interleukin-37 production.
regulation of interleukin-37 biosynthetic process
The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
interleukin-37 biosynthetic process
Any process that modulates the frequency, rate or extent of CD86 biosynthetic process.
regulation of CD86 biosynthetic process
Any process that modulates the frequency, rate or extent of CD80 biosynthetic process.
regulation of CD80 biosynthetic process
Any process that modulates the frequency, rate or extent of interleukin-17A production.
regulation of interleukin-17A biosynthetic process
Any process that modulates the frequency, rate or extent of interleukin-34 production.
interleukin-34 biosynthetic process
regulation of interleukin-34 biosynthetic process
Any process that modulates the frequency, rate or extent of interleukin-32 production.
regulation of interleukin-32 biosynthetic process
regulation of interleukin-32 secretion
The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-cerebrospinal fluid barrier.
transport across BCSFB
transport across blood-CSF barrier
transport across blood/cerebrospinal fluid barrier
transport across blood/CSF barrier
Any process that modulates the frequency, rate or extent of gene expression by which developmental control passes from the maternal genome to the zygotic genome.
MZT
A protein complex associated with the mitotic spindle pole body during interphase and mitosis and comprises of the proteins of the septation initiation signaling network (SIN) of fission yeast or mitotic exit network (MEN) of budding yeast, organized by two scaffold/adaptor proteins.
Hippo signaling complex
MEN signaling complex
SIN signaling complex
SIN/MEN signalling complex
Enables the transmembrane transfer of an inorganic ion by a channel that opens in response to a change in proton concentration (pH).
acid-sensing ion channel activity
proton-gated ion channel activity
The chemical reactions and pathways involving an L-amino acid.
L-alpha-amino acid metabolism
L-amino acid metabolism
The chemical reactions and pathways resulting in the formation of L-amino acids, the L-enantiomers of amino acids.
L-amino acid anabolism
L-amino acid biosynthesis
L-amino acid formation
L-amino acid synthesis
The chemical reactions and pathways resulting in the breakdown of an L-amino acid.
L-amino acid breakdown
L-amino acid catabolism
L-amino acid degradation
The chemical reactions and pathways resulting in the formation of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
proteinogenic amino acid anabolism
proteinogenic amino acid biosynthesis
proteinogenic amino acid formation
proteinogenic amino acid synthesis
The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
proteinogenic amino acid metabolism
The chemical reactions and pathways resulting in the breakdown of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
proteinogenic amino acid breakdown
proteinogenic amino acid catabolism
proteinogenic amino acid degradation
The chemical reactions and pathways involving non-proteingenic amino acids.
non-proteinogenic amino acid metabolism
The chemical reactions and pathways resulting in the formation of non-proteinogenic amino acids.
non-proteinogenic amino acid anabolism
non-proteinogenic amino acid formation
non-proteinogenic amino acid synthesis
non-proteinogenic biosynthesis
The chemical reactions and pathways resulting in the breakdown of non-proteinogenic amino acids.
non-proteinogenic amino acid breakdown
non-proteinogenic amino acid catabolism
non-proteinogenic amino acid degradation
A ribonucleoprotein complex consisting of a box C/D type snRNA and three (Archaea) or four (Eukaryotes) core proteins that have diverse functions, including site-specific methylation of rRNA and processing rRNA.
SNORD ribonucleoprotein complex
SNORNP
Binds to and increases the activity of a ribonuclease.
RNA nuclease activator activity