NothingMuch/GO-Terms huggingface dataset:
A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed.
cell cycle quiescence
cellular quiescence
G0 phase
quiescence
The process by which a symbiont acquires iron from its host, either from heme or other iron containing molecules such as transferrin and lactoferrin. Begins with either the secretion of symbiont gene products that bind iron- or heme-containing molecules (siderophores and hemophores) from the symbiont cell into the host, or by expression of receptors that bind iron- or heme-containing molecules on the symbiont cell surface. Ends when the iron-containing compound is transported into the symbiont cell.
acquisition by organism of nutrients from host via siderophores
acquisition by symbiont of nutrients from host via siderophores
heme acquisition
iron acquisition
iron acquisition by symbiont from host
iron acquisition by symbiont from host heme
Any process where an infecting virus stops, prevents, or reduces the frequency, rate or extent of its host's cell division.
inhibition by virus of host cell division
Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 = gamma-glutamyl-hercynyl cysteine sulfoxide + H2O.
gamma-glutamyl hercynylcysteine S-oxide synthase
gamma-glutamyl hercynylcysteine sulfoxide synthase
A signaling process that contributes to a mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed.
cytokinesis after mitosis checkpoint
defective cytokinesis checkpoint
mitotic cytokinesis checkpoint
signal transduction involved in mitotic cytokinesis checkpoint
signaling pathway involved in mitotic cytokinesis checkpoint
signalling cascade involved in mitotic cytokinesis checkpoint
signalling pathway involved in mitotic cytokinesis checkpoint
A signaling process that contributes to a mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth.
morphogenesis checkpoint
septin checkpoint
signal transduction involved in morphogenesis checkpoint
signal transduction involved in septin checkpoint
signaling cascade involved in morphogenesis checkpoint
signaling cascade involved in septin checkpoint
signaling pathway involved in morphogenesis checkpoint
signaling pathway involved in septin checkpoint
signalling cascade involved in morphogenesis checkpoint
signalling cascade involved in septin checkpoint
signalling pathway involved in morphogenesis checkpoint
signalling pathway involved in septin checkpoint
Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.
HDEL receptor activity
The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment.
retrograde transport from the vacuole
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
down regulation of nitric oxide biosynthetic process
down-regulation of nitric oxide biosynthetic process
downregulation of nitric oxide biosynthetic process
inhibition of nitric oxide biosynthetic process
negative regulation of nitric oxide anabolism
negative regulation of nitric oxide biosynthesis
negative regulation of nitric oxide formation
negative regulation of nitric oxide synthesis
A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.
mtEXO
Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP.
UDP-activated nucleotide receptor activity
Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP.
purinoceptor type U
uridine nucleotide receptor activity
UTP-activated nucleotide receptor activity
Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
ATP-activated adenosine receptor activity
ATP-activated nucleotide receptor activity
The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron).
sense organ precursor cell division
The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved.
protein-chloroplast targeting
The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma.
chloroplast thylakoid membrane protein import
protein transport into chloroplast thylakoid membrane
The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane.
mitochondrial inner membrane protein import
protein import into mitochondrial inner membrane
protein transport into mitochondrial inner membrane
The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import.
peroxisome membrane protein import
protein transport into peroxisome membrane
A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER.
N-terminal cleaved signal sequence mediated protein insertion into ER membrane
protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence
protein insertion into ER membrane, N-terminal cleaved signal sequence mediated
protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence
protein-ER insertion by N-terminal cleaved signal sequence
A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix.
protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence
protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated
protein-endoplasmic reticulum insertion by stop-transfer membrane-anchor sequence
protein-ER insertion by stop-transfer membrane-anchor sequence
stop-transfer membrane-anchor sequence mediated protein insertion into ER membrane
A process of protein insertion into the endoplasmic reticulum (ER) membrane in which signal anchor sequences function as both ER signal sequences and membrane anchor sequences.
internal uncleaved signal-anchor sequence mediated protein insertion into ER membrane
protein insertion into endoplasmic reticulum membrane by internal uncleaved signal-anchor sequence
protein insertion into ER membrane, internal uncleaved signal-anchor sequence mediated
protein-endoplasmic reticulum insertion by internal uncleaved signal-anchor sequence
protein-ER insertion by internal uncleaved signal-anchor sequence
The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known.
maintenance of protein location in Golgi apparatus
protein-Golgi retention
retention of protein in Golgi
The process that results in the physical movement of a new cis-Golgi stack from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna.
cisternal maturation
The process of elimination of immature T cells in the thymus which react strongly with self-antigens.
negative thymic T lymphocyte selection
negative thymic T-cell selection
negative thymic T-lymphocyte selection
The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.
positive extrathymic T lymphocyte selection
positive extrathymic T-cell selection
positive extrathymic T-lymphocyte selection
The process of elimination of extrathymically maturing T cells which react strongly with self-antigens.
negative extrathymic T lymphocyte selection
negative extrathymic T-cell selection
negative extrathymic T-lymphocyte selection
A protein complex that binds interleukin-18; comprises an alpha and a beta subunit.
IL-18 receptor complex
A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins.
acidic keratin
basic/neutral keratin
A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments.
desmin
glial fibrillary acidic protein
peripherin
type III intermediate filament associated protein
vimentin
Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + H+.
2-acetylamino-2-deoxy-D-glucose kinase activity
acetylaminodeoxyglucokinase activity
acetylglucosamine kinase (phosphorylating)
ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity
ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity
GlcNAc kinase activity
Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.
down regulation of meiotic recombination
down-regulation of meiotic recombination
downregulation of meiotic recombination
inhibition of meiotic recombination
suppression of meiotic recombination
Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate.
3\'-phosphoadenylyl keratan sulfotransferase activity
3\'-phosphoadenylyl-sulfate:keratan 6\'-sulfotransferase activity
3\'-phosphoadenylylsulfate:keratan sulfotransferase activity
keratan sulfate Gal-6-sulfotransferase activity
keratan sulfate sulfotransferase activity
keratan sulphotransferase activity
Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H+.
2,3-dihydroxybenzoate 1,2-dioxygenase activity
2,3-dihydroxybenzoate oxygenase activity
2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)
2,3-dihydroxybenzoic oxygenase activity
o-pyrocatechuate oxygenase activity
Catalysis of the reaction: UDP + H2O = UMP + phosphate.
UDP phosphohydrolase activity
UDPase activity
uridine 5\'-diphosphatase activity
uridine diphosphatase activity
uridine-diphosphatase activity
Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends.
alginase activity
alginase I
alginate lyase activity
alginate lyase I activity
poly(beta-D-1,4-mannuronide) lyase activity
poly(mana) alginate lyase activity
Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol.
IPC synthase activity
Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule.
single-stranded DNA specific 5\'-3\' exodeoxyribonuclease activity
ssDNA-specific 5\'-3\' exodeoxyribonuclease activity
Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide.
alanine-phenylalanine-proline arylamidase activity
aminoexotripeptidase activity
aminotripeptidase activity
imidoendopeptidase activity
lymphopeptidase activity
peptidase B
peptidase T
The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone.
acetoin breakdown
acetoin catabolism
acetoin degradation
The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone.
acetoin anabolism
acetoin biosynthesis
acetoin formation
acetoin synthesis
Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator.
antisigma factor antagonist activity
Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis.
cytochrome
cytochrome bc1 complex
Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis.
cytochrome
Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II.
cytochrome
cytochrome b/b6
cytochrome b6
cytochrome f
The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization.
clustering of voltage gated sodium channels
clustering of voltage-dependent sodium channels
Nav channel clustering
voltage-gated sodium channel clustering
The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode.
clustering of voltage gated potassium channels
clustering of voltage-dependent potassium channels
Kv channel clustering
voltage-gated potassium channel clustering
The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.
O-sialoglycoprotein breakdown
O-sialoglycoprotein catabolism
O-sialoglycoprotein degradation
Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.
dehydroascorbate reductase activity
dehydroascorbic acid reductase activity
dehydroascorbic reductase activity
DHA reductase activity
GDOR
glutathione dehydroascorbate reductase activity
glutathione:dehydroascorbate oxidoreductase activity
glutathione:dehydroascorbic acid oxidoreductase activity
Any process in which a protein is transported to, or maintained in, basal regions of the cell.
basal protein localisation
establishment and maintenance of basal protein localization
establishment and maintenance of protein localization in basal part of cell
Any process in which a protein is transported to, or maintained in, apical regions of the cell.
apical protein localisation
establishment and maintenance of apical protein localization
establishment and maintenance of protein localization in apical part of cell
The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.
establishment of neuroblast cell polarity
The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.
maintenance of neuroblast cell polarity
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.
activation of FasL biosynthetic process
positive regulation of FasL anabolism
positive regulation of FasL biosynthesis
positive regulation of FasL biosynthetic process
positive regulation of FasL formation
positive regulation of FasL synthesis
stimulation of FasL biosynthetic process
up regulation of FasL biosynthetic process
up-regulation of FasL biosynthetic process
upregulation of FasL biosynthetic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.
down regulation of FasL biosynthetic process
down-regulation of FasL biosynthetic process
downregulation of FasL biosynthetic process
inhibition of FasL biosynthetic process
negative regulation of FasL anabolism
negative regulation of FasL biosynthesis
negative regulation of FasL biosynthetic process
negative regulation of FasL formation
negative regulation of FasL synthesis
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.
activation of CD4 biosynthetic process
positive regulation of CD4 anabolism
positive regulation of CD4 biosynthesis
positive regulation of CD4 biosynthetic process
positive regulation of CD4 formation
positive regulation of CD4 synthesis
stimulation of CD4 biosynthetic process
up regulation of CD4 biosynthetic process
up-regulation of CD4 biosynthetic process
upregulation of CD4 biosynthetic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.
down regulation of CD4 biosynthetic process
down-regulation of CD4 biosynthetic process
downregulation of CD4 biosynthetic process
inhibition of CD4 biosynthetic process
negative regulation of CD4 anabolism
negative regulation of CD4 biosynthesis
negative regulation of CD4 biosynthetic process
negative regulation of CD4 formation
negative regulation of CD4 synthesis
The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall.
slime layer polysaccharide anabolism
slime layer polysaccharide biosynthesis
slime layer polysaccharide formation
slime layer polysaccharide synthesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an S-layer enveloping the cell. The S-layer is a crystalline protein layer surrounding some bacteria.
S-layer organisation
S-layer organization and biogenesis
The covalent attachment of a palmitoleyl group to a protein.
protein amino acid palmitoleylation
Binding to a CXCR1 chemokine receptor.
CXCR1 chemokine receptor ligand
Binding to a CXCR2 chemokine receptor.
CXCR2 chemokine receptor ligand
A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.
succinyl-CoA synthetase, GDP-forming
A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.
alpha-ketoglutarate dehydrogenase complex
dihydrolipoamide S-succinyltransferase complex
KGDHC
A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.
pyruvate dehydrogenase complex (lipoamide)
One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core.
hydrogen-transporting ATP synthase, stator stalk
The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase.
hydrogen-transporting ATP synthase, catalytic core
One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis.
hydrogen-transporting ATP synthase, central stalk
Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex.
electron transport complex I
NADH dehydrogenase (ubiquinone) complex
NADH dehydrogenase complex (ubiquinone)
NADH-Q oxidoreductase complex
A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.
electron transport complex II
A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species.
coenzyme Q-cytochrome c oxidoreductase complex
coenzyme Q-cytochrome c reductase complex
complex III
CoQH2-cytochrome c reductase complex
cytochrome bc(1) complex
cytochrome bc1 complex
electron transport complex III
ubiquinol-cytochrome c oxidoreductase complex
ubiquinol-cytochrome-c reductase complex
A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
cytochrome c oxidase complex
electron transport complex IV
Binding to catenin complex gamma subunit.
plakoglobin binding
Catalysis of the reaction: 2 H+ + O2 + octadecanoyl- + 2 reduced - = (9Z)-octadecenoyl- + 2 H2O + 2 oxidized -.
acyl- desaturase activity
acyl-acyl-carrier-protein desaturase activity
acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity
stearyl acyl carrier protein desaturase activity
stearyl-ACP desaturase activity