NothingMuch/GO-Terms huggingface dataset:
A protein-containing complex composed of six subunits of each of the three homologous polypeptide chains C1QA, C1QB, and C1QB. It is a subunit of the complement C1 complex. In addition to complement activation, C1q appears to have roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning.
C1q
Complement 1q
The chemical reactions and pathways resulting in the formation of lutein.
lutein anabolism
lutein biosynthesis
lutein formation
The chemical reactions and pathways resulting in the breakdown of lutein.
lutein breakdown
lutein catabolism
lutein degradation
The chemical reactions and pathways resulting in the formation of brexanolone.
allopregnanolone anabolism
allopregnanolone biosynthesis
allopregnanolone biosynthetic process
allopregnanolone synthesis
allotetrahydroprogesterone anabolism
allotetrahydroprogesterone biosynthesis
allotetrahydroprogesterone biosynthetic process
allotetrahydroprogesterone synthesis
brexanolone anabolism
brexanolone biosynthesis
brexanolone synthesis
The chemical reactions and pathways resulting in the breakdown of brexanolone.
allopregnanolone breakdown
allopregnanolone catabolic process
allopregnanolone catabolism
allopregnanolone degradation
allotetrahydroprogesterone breakdown
allotetrahydroprogesterone catabolic process
allotetrahydroprogesterone catabolism
allotetrahydroprogesterone degradation
brexanolone breakdown
brexanolone catabolism
brexanolone degradation
A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability.
R-loop disassembly
The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactoxylomannan. Galactoxylomannan is produced by a pathogenic fungus and causes paralysis in some animals.
galactoxylomannan anabolism
galactoxylomannan biosynthesis
galactoxylomannan formation
galactoxylomannan synthesis
GalXM biosynthetic process
glucuronoxylomannogalactan biosynthetic process
An intracellular signaling cascade that starts with the activation of S. cerevisiae Kic1p, which activate Mob2p and Cbk1p. Cbk1p phosphorylates Ace2p, which results in its nuclear translocation, where it regulates transcription of genes involved in polarity and morphogenesis.
MOR signaling pathway
morphogenesis Orb6 network
RAM signaling pathway
RAM/MOR signaling pathway
Catalysis of the reaction: (+)-copalyl diphosphate = diphosphate + miltiradiene.
multiradiene synthase activity
Any process that modulates the distribution of sites along the chromosome where meiotic DNA double-strand break formation takes place as part of reciprocal meiotic recombination.
crossover interference
DSB interference
regulation of spatial distribution of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
regulation of spatial distribution of meiotic DSB formation involved in reciprocal meiotic recombination
The regeneration process by which a damaged or lost shoot regrows or re-differentiates. This process may occur via de-differentiation and subsequent reprogramming of somatic cells or activation of existing undifferentiated (meristematic) cells to produce a new shoot meristem and subsequently a new shoot.
shoot system regeneration
Any process that modulates the frequency, rate or extent of firing from an early origin of replication involved in mitotic DNA replication.
regulation of early replication origin firing
The chemical reactions and pathways resulting in the breakdown of platelet activating factor, 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine.
2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine catabolic process
PAF catabolic process
The aggregation, arrangement and bonding together of a set of components to form an axonemal basal plate.
axonemal basal plate formation
axoneme basal plate assembly
basal plate assembly
A DNA-binding ribonucleoprotein complex that contains a lncRNA complementary to the bound chromosomal locus and is involved in the tethering homologous chromosomes together during chromosome pairing at meiotic prophase I.
Smp dot
Binding to heterochromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization.
heterochromatin-nuclear membrane tether activity
nuclear membrane-heterochromatin anchor activity
nuclear membrane-heterochromatin tether activity
Binding to euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization.
euchromatin-nuclear membrane tether activity
nuclear membrane-euchromatin anchor activity
nuclear membrane-euchromatin tether activity
Binding to DNA double strand breaks and the nuclear inner membrane, in order to facilitate DNA repair.
DNA repair factory
The outer of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory.
outer membrane of double membrane vesicle viral factory
The volume surrounded by the inner membrane of a double membrane vesicle viral factory.
lumen of double membrane vesicle viral factory
The inner of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory.
inner membrane of double membrane vesicle viral factory
A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities.
oligo-1,6-glucosidase complex
Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation.
Arm repeat domain binding
armadillo domain binding
armadillo repeat binding
A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin.
ITGAV-ITGB3-THBS1 complex
A protein complex that is formed by the association of a TGF-beta dimeric ligand with 2 molecules of each receptor molecule, TGF-beta type I receptor and TGF-beta type II receptor. The receptor molecules may form homo- or heterodimers but only once bound by the ligand.
TGF-beta 1:type II receptor:type I receptor complex
TGF-beta ligand-receptor complex
TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex
TGF-beta1 ligand-receptor complex
TGF-beta1-beta2 ligand-receptor complex
TGF-beta1-type II receptor-type I receptor complex
TGF-beta2 ligand-receptor complex
TGFb ligand-receptor complex
TGFbeta ligand-receptor complex
TGFbeta1 ligand-receptor complex
TGFbeta1-beta2 ligand-receptor complex
TGFbeta2 ligand-receptor complex
transforming growth factor beta1-type II receptor-type I receptor complex
A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer.
IL12-IL12 receptor complex
IL12B-IL12RB1-IL12RB2 complex
A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K).
CD19-Vav-PI 3-kinase (p85 subunit) complex
Binding to carbon monoxide (CO).
CO binding
Binding to nitric oxide (NO).
nitrogen monoxide binding
nitrosyl binding
NO binding
Binding to and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO).
carbon monoxide sensing activity
A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin.
ITGAV-ITGB3-SPP1 complex
A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin.
ITGAV-ITGB1-SPP1 complex
A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin.
ITGAV-ITGB5-SPP1 complex
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).
SNARE complex (Vamp2, Snap25, Stx1a, Cplx1)
Vamp2-Snap25-Stx1a-Cplx1 complex
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).
SNARE complex (Vamp2, Snap25, Stx1a, Cplx2)
Vamp2-Snap25-Stx1a-Cplx2 complex
Binding to the telomerase RNA template.
TERC binding
Catalysis of the reaction: adenosine2503 in 23S rRNA + 2 reduced - + 2 S-adenosyl-L-methionine = 2-methyladenosine2503 in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized - + S-adenosyl-L-homocysteine.
rRNA (adenine-C2-)-methyltransferase activity
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).
Snap25-Stx1a-Vamp2 complex
SNARE complex (Snap25, Stx1a, Vamp2)
SNARE complex (Stx1a, SNAP25, VAMP)
Stx1a-SNAP25-VAMP complex
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof).
SNARE complex (Stx2, Snap25, Vamp2)
Stx2-Snap25-Vamp2 complex
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof).
SNARE complex (Stx3, Snap25, Vamp2)
Stx3-Snap25-Vamp2 complex
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof).
SNARE complex (Stx4, Snap25, Vamp2)
Stx4-Snap25-Vamp2 complex
A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof).
SNARE complex (Stx1a, Snap25, Vamp8)
Stx1a-Snap25-Vamp8 complex
A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof).
SNARE complex (Stx2, Snap25, Vamp8)
Stx2-Snap25-Vamp8 complex
Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
cytosolic mRNA splicing
The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization.
forespore membrane leading edge
The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus.
forespore membrane SPB attachment site
forespore membrane spindle pole body attachment site
prospore membrane SPB attachment site
The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament.
formin-mediated actin filament nucleation
unbranched actin filament nucleation
A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof).
SNARE complex (Vamp3, Vamp4, Stx16)
Vamp3-Vamp4-Stx16 complex
A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof).
SNARE complex (Vamp3, Vamp4, Vam8, Stx6)
Vamp3-Vamp4-Vam8-Stx6 complex
A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof).
SNARE complex (Vamp4, Stx6, Stx16, Vti1a)
Vamp4-Stx6-Stx16-Vti1a complex
The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane.
V-ATPase assembly
V-ATPase complex assembly
The process in which voltage-gated calcium channels become localized together in high densities.
clustering of voltage gated calcium channels
clustering of voltage-dependent calcium channels
voltage-gated calcium channel clustering
Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
Z repeat domain binding
The volume enclosed by the membrane of the clathrin-sculpted monoamine transport vesicle.
clathrin sculpted monoamine constitutive secretory pathway transport vesicle lumen
clathrin sculpted monoamine transport vesicle lumen
The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle.
clathrin sculpted monoamine constitutive secretory pathway transport vesicle membrane
clathrin sculpted monoamine transport vesicle membrane
Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.
chromoshadow domain binding
An inclusion body located in the cytoplasm of prokaryotes that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR.
carbonosome
PHA granule
PHB granule
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.
down regulation of glucagon secretion
down-regulation of glucagon secretion
downregulation of glucagon secretion
inhibition of glucagon secretion
Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.
activation of glucagon secretion
stimulation of glucagon secretion
up regulation of glucagon secretion
up-regulation of glucagon secretion
upregulation of glucagon secretion
Binding to fructose 6-phosphate.
D-fructose 6-phosphate binding
fructose 6-phosphate binding
The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex.
mitochondrion outer membrane translocase complex assembly
TOM complex assembly
Any process that decreases the rate, frequency or extent of an interleukin-6-mediated signaling pathway.
negative regulation of IL-6-mediated signaling pathway
negative regulation of interleukin-6-mediated signalling pathway
Any process that increases the rate, frequency or extent of an interleukin-6-mediated signaling pathway.
positive regulation of IL-6-mediated signaling pathway
positive regulation of interleukin-6-mediated signalling pathway
Any process that decreases the rate, frequency or extent of an interleukin-27-mediated signaling pathway.
negative regulation of IL-27-mediated signaling pathway
negative regulation of IL27RA/IL6ST signaling pathway
negative regulation of interleukin-27-mediated signalling pathway
Any process that increases the rate, frequency or extent of an interleukin-27-mediated signaling pathway.
positive regulation of IL-27-mediated signaling pathway
positive regulation of IL27RA/IL6ST signaling pathway
positive regulation of interleukin-27-mediated signalling pathway
The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore.
Paulinella-type chromatophore inner membrane
The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore.
Paulinella-type chromatophore outer membrane
The region between the inner and outer lipid bilayers that surround an organellar chromatophore.
Paulinella-type chromatophore intermembrane space
The volume enclosed by an organellar chromatophore thylakoid membrane.
Paulinella-type chromatophore thylakoid lumen
The lipid bilayer membrane of any thylakoid within an organellar chromatophore.
Paulinella-type chromatophore thylakoid membrane
Binding to the cytokine ciliary neurotrophic factor.
CNTF binding
The series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
ciliary neurotrophic factor-mediated signalling pathway
CNTF-mediated signaling pathway
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
KV development
Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors.
betaglycan
endoglin
transforming growth factor beta ligand binding to type III receptor
type III TGF-beta receptor activity
type III TGFbeta receptor activity
type III transforming growth factor beta receptor activity
The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa).
mitochondrial translation termination
Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.
negative regulation of mitochondrial translation initiation
Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.
positive regulation of mitochondrial translation initiation
The chemical reactions and pathways resulting in the formation of beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan.
beta-1,2-oligomannoside anabolism
beta-1,2-oligomannoside biosynthesis
beta-1,2-oligomannoside formation
beta-1,2-oligomannoside synthesis
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell.
down regulation of adiponectin secretion
down-regulation of adiponectin secretion
downregulation of adiponectin secretion
inhibition of adiponectin secretion
Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell.
activation of adiponectin secretion
stimulation of adiponectin secretion
up regulation of adiponectin secretion
up-regulation of adiponectin secretion
upregulation of adiponectin secretion
A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification.
DP/Rb/MuvB
The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine.
D-serine anabolism
D-serine biosynthesis
D-serine formation
D-serine synthesis
Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA.
18S rRNA binding
SSU rRNA binding
The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth.
GH activity
pituitary growth hormone activity
placental growth hormone activity
A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1.
Pot1 complex
Pot1-Tpz1 complex
telosome
The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex.
eIF-3 assembly
eIF3 assembly
The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation.
attachment of telomeres to nuclear envelope
attachment of telomeric chromatin to nuclear envelope
Catalysis of the reaction: 2-oxoglutarate + H+ + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.
MenD
SEPHCHC synthase activity
Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate.
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity
6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity
MenH
SHCHC synthase activity
YfbB
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
protein homotrimer assembly
protein homotrimer biosynthesis
protein homotrimer biosynthetic process
protein homotrimer formation
The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical.
protein heterotrimer assembly
protein heterotrimer biosynthesis
protein heterotrimer biosynthetic process
protein heterotrimer formation
A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.
Clr6-LE complex
The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain.
addition of poly-ADP-ribose to protein
poly(ADP-ribose) addition to protein
protein amino acid poly-ADP-ribosylation
protein poly(ADP-ribose) metabolism
protein poly(ADP-ribose) synthesis
The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.
protein amino acid auto-ADP-ribosylation
The aggregation, arrangement and bonding together of a set of components to form a transcription factor TFIIIB complex.
TFIIIB assembly
A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase, and requires the presence of oxygen.
aerobic sulphur oxidation
A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase.
sulfide oxidation, using sulfide-quinone reductase
sulphide oxidation, using sulfide:quinone oxidoreductase
A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide dehydrogenase.
sulphide oxidation, using sulfide dehydrogenase
A sulfide oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase.
sulphide oxidation, using sulfur dioxygenase
Catalysis of the reaction: H2S (hydrogen sulfide) + a quinone = S0 (sulfane sulfur) + a hydroquinone.
sulfide-quinone reductase activity
sulphide:quinone oxidoreductase activity
Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S + reduced cytochrome c.
flavocytochrome c sulfide dehydrogenase activity
sulphide dehydrogenase activity
Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+.
hydrogen sulfide:ferric ion oxidoreductase