NothingMuch/GO-Terms huggingface dataset:
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system.
down regulation of two-component signal transduction
down-regulation of two-component signal transduction
downregulation of two-component signal transduction
inhibition of two-component signal transduction
negative regulation of histidyl-aspartyl phosphorelay
negative regulation of two-component signal transduction system (phosphorelay)
Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade.
regulation of SAPK signaling pathway
regulation of stress-activated protein kinase signaling pathway
regulation of stress-activated protein kinase signalling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
down regulation of stress-activated protein kinase signaling pathway
down-regulation of stress-activated protein kinase signaling pathway
downregulation of stress-activated protein kinase signaling pathway
inhibition of stress-activated protein kinase signaling pathway
negative regulation of SAPK signaling pathway
negative regulation of stress-activated protein kinase signaling pathway
negative regulation of stress-activated protein kinase signalling pathway
Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
activation of stress-activated protein kinase signaling pathway
positive regulation of SAPK signaling pathway
positive regulation of stress-activated protein kinase signaling pathway
positive regulation of stress-activated protein kinase signalling pathway
stimulation of stress-activated protein kinase signaling pathway
up regulation of stress-activated protein kinase signaling pathway
up-regulation of stress-activated protein kinase signaling pathway
upregulation of stress-activated protein kinase signaling pathway
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus.
response to 3\',5\' cGMP
response to 3\',5\'-cGMP
response to cyclic GMP
response to guanosine 3\',5\'-cyclophosphate
The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.
lens fibre cell differentiation
The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
lens fibre cell development
A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence.
cell cycle quiescence
establishment of cell quiescence
G1/G0 transition
stationary phase
Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.
triacylglycerol homeostasis
The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat.
adipocyte proliferation
adipose cell proliferation
The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species.
brown adipocyte proliferation
brown adipose cell proliferation
The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population.
white adipocyte proliferation
white adipose cell proliferation
Any process that modulates the frequency, rate or extent of fat cell proliferation.
regulation of adipocyte proliferation
regulation of adipose cell proliferation
Any process that stops or decreases the rate or extent of fat cell proliferation.
down regulation of fat cell proliferation
down-regulation of fat cell proliferation
downregulation of fat cell proliferation
inhibition of fat cell proliferation
negative regulation of adipocyte proliferation
negative regulation of adipose cell proliferation
Any process that activates or increases the rate or extent of fat cell proliferation.
activation of fat cell proliferation
positive regulation of adipocyte proliferation
positive regulation of adipose cell proliferation
stimulation of fat cell proliferation
up regulation of fat cell proliferation
up-regulation of fat cell proliferation
upregulation of fat cell proliferation
Any process that modulates the frequency, rate or extent of brown fat cell proliferation.
regulation of brown adipocyte proliferation
regulation of brown adipose cell proliferation
Any process that modulates the frequency, rate or extent of white fat cell proliferation.
regulation of white adipocyte proliferation
regulation of white adipose cell proliferation
A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell.
cell motility by actin tail formation
The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.
liver cell differentiation
Any process that modulates the frequency, rate or extent of hepatocyte differentiation.
regulation of liver cell differentiation
A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development.
ERK cascade
ERK1 and ERK2 signaling pathway
ERK1 and ERK2 signalling pathway
ERK1 cascade
ERK1/2 cascade
ERK2 cascade
extracellular signal-regulated kinase 1/2 (ERK1/2) cascade
extracellular signal-regulated kinase 1/2 cascade
MAPK1 cascade
MAPK3 cascade
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
regulation of ERK cascade
regulation of ERK1 and ERK2 signaling pathway
regulation of ERK1 and ERK2 signalling pathway
regulation of ERK1 cascade
regulation of ERK1/2 cascade
regulation of ERK2 cascade
regulation of MAPK1 cascade
regulation of MAPK3 cascade
A MAPK cascade containing at least the ERK5 MAP kinase (MAPK7; also called BMK1). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK5. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The ERK5 cascade is activated by stress, mitogens, and by G protein-coupled receptors, and results in cellular responses such as cell growth, cell differentiation and development.
big MAP kinase signaling cascade
BMK cascade
BMK signaling pathway
BMK signalling pathway
BMK1 cascade
ERK5 signaling pathway
extracellular signal-regulated kinase 5 cascade
MAPK7 cascade
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.
regulation of BMK cascade
regulation of BMK signaling pathway
regulation of BMK signalling pathway
regulation of BMK1 cascade
regulation of ERK5 signaling pathway
regulation of MAPK7 cascade
A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
exocytic constitutive secretory pathway transport vesicle
exocytotic vesicle
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
response to LTA
The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues.
teichoic acid breakdown
teichoic acid catabolism
teichoic acid degradation
The chemical reactions and pathways involving lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
lipoteichoic acid metabolism
LTA metabolic process
The chemical reactions and pathways involving wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan.
wall teichoic acid metabolism
WTA metabolic process
The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid.
teichoic acid alanylation
The chemical reactions and pathways involving carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways.
carbamoyl phosphate metabolism
The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress.
trehalose metabolic process involved in response to stress  systematic_synonym
The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
trehalose metabolic process involved in response to heat stress  systematic_synonym
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
cellular response to cold stress
A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends.
NHEJ complex
non-homologous end joining complex
Any process that modulates the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway.
regulation of NOD signaling pathway
regulation of nucleotide-binding oligomerization domain containing signaling pathway
regulation of nucleotide-binding oligomerization domain containing signalling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway.
negative regulation of NOD signaling pathway
negative regulation of nucleotide-binding oligomerization domain containing signaling pathway
negative regulation of nucleotide-binding oligomerization domain containing signalling pathway
Any process that activates or increases the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway.
positive regulation of NOD signaling pathway
positive regulation of nucleotide-binding oligomerization domain containing signaling pathway
positive regulation of nucleotide-binding oligomerization domain containing signalling pathway
The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 1 (NOD1) protein receptor, and ending with regulation of a downstream cellular process.
NOD1 signaling pathway
nucleotide-binding oligomerization domain containing 1 signalling pathway
Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway.
regulation of NOD1 signaling pathway
regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway
The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process.
NOD2 signaling pathway
nucleotide-binding oligomerization domain containing 2 signalling pathway
Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.
regulation of NOD2 signaling pathway
regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway
The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system.
oligodendrocyte precursor proliferation
Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation.
regulation of oligodendrocyte precursor proliferation
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.
regulation of haem biosynthesis
regulation of haem biosynthetic process
regulation of heme anabolism
regulation of heme biosynthesis
regulation of heme formation
regulation of heme synthesis
The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary.
thyroid stimulating hormone secretion
TSH secretion
A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs).
SAGA family complex
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth.
myometrial contraction
myometrial smooth muscle contraction
myometrium contraction
Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction.
regulation of myometrial contraction
regulation of myometrial smooth muscle contraction
regulation of myometrium contraction
The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
detection of reduced oxygen levels
The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one.
dehydro-D-arabinono-1,4-lactone metabolism
The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules.
immune cell aggregation
leucocyte aggregation
white blood cell aggregation
white corpuscle aggregation
The adhesion of one monocyte to one or more other monocytes via adhesion molecules.
mononuclear phagocyte aggregation
The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules.
neutrocyte aggregation
neutrophil leucocyte aggregation
neutrophil leukocyte aggregation
neutrophilic leucocyte aggregation
neutrophilic leukocyte aggregation
The adhesion of one T cell to one or more other T cells via adhesion molecules.
T lymphocyte aggregation
T-cell aggregation
T-lymphocyte aggregation
A G protein-coupled receptor signaling pathway initiated by thrombin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
thrombin receptor signaling pathway
thrombin receptor signalling pathway
Any process that modulates the frequency, rate or extent of a thrombin-activated receptor signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
regulation of thrombin receptor signaling pathway
regulation of thrombin receptor signalling pathway
The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-1 alpha-mediated signaling pathway
IL-1 beta-mediated signaling pathway
IL-1-mediated signaling pathway
interleukin-1 alpha-mediated signaling pathway
interleukin-1 beta-mediated signaling pathway
interleukin-1-mediated signalling pathway
The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds.
poly-gamma-glutamate anabolism
poly-gamma-glutamate biosynthesis
poly-gamma-glutamate formation
poly-gamma-glutamate synthesis
The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments.
selenium-containing prosthetic group metabolism
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
regulation of microtubule cytoskeleton organisation
regulation of microtubule dynamics
The directed movement of cholesterol into a cell or organelle.
cholesterol uptake
The directed movement of calcium ions into a cell or organelle.
calcium ion uptake
transmembrane calcium influx
Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+.
beta-hydroxysteroid dehydrogenase
corticosteroid 11-beta-dehydrogenase activity
The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.
t6A metabolic process
t6A metabolism
threonylcarbamoyladenosine metabolism
The adhesion of one platelet to one or more other platelets via adhesion molecules.
blood platelet aggregation
thrombocyte aggregation
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
PKC signal transduction
PKC signaling cascade
protein kinase C signal transduction
protein kinase C signaling cascade
protein kinase C signalling cascade
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
protein K63-linked polyubiquitination
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus.
response to platinum
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus.
response to linoleate
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
response to IL-1
A nuclear receptor-mediated signaling pathway initiated by vitamin D binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
calcitriol signaling pathway
intracellular vitamin D receptor signaling pathway
nuclear receptor-mediated vitamin D signaling pathway
VDR signaling pathway
vitamin D receptor signalling pathway
Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity.
regulation of VDR signaling pathway
regulation of vitamin D receptor signalling pathway
Catalysis of the transfer of an uridylyl group to an acceptor.
uridyl transferase activity
uridyltransferase activity
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.
growth cone collapse
A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
cadmium ion membrane transport
transmembrane cadmium transport
Catalysis of the hydroxylation of C-24 of any form of vitamin D.
calciferol 24-hydroxylase activity
cholecalciferol 24-hydroxylase activity
ergocalciferol 24-hydroxylase activity
vitamin D2 24-hydroxylase activity
vitamin D3 24-hydroxylase activity
A process in which a protein is transported to, or maintained in, a location within the mitochondrion.
protein localisation in mitochondrion
protein localization in mitochondrion
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
calcium ion membrane transport
transmembrane calcium transport
The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall.
cell wall polysaccharide anabolism
cell wall polysaccharide biosynthesis
cell wall polysaccharide synthesis
The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds.
1,3-alpha-glucan metabolic process
1,3-alpha-glucan metabolism
alpha-1,3 glucan metabolic process
alpha-1,3 glucan metabolism
The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds.
1,3-alpha-glucan anabolism
1,3-alpha-glucan biosynthesis
1,3-alpha-glucan biosynthetic process
1,3-alpha-glucan formation
1,3-alpha-glucan synthesis
alpha-1,3 glucan anabolism
alpha-1,3 glucan biosynthesis
alpha-1,3 glucan biosynthetic process
alpha-1,3 glucan formation
alpha-1,3 glucan synthesis