NothingMuch/GO-Terms huggingface dataset:
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
anterograde axon cargo transport
The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
retrograde axon cargo transport
The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way.
cytoskeletal adaptor activity
Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.
adenosinetriphosphatase (DNA-dependent)
ATPase activity, acting on DNA
ATPase, acting on DNA
DNA dependent ATPase activity
DNA-dependent adenosinetriphosphatase activity
DNA-dependent ATPase activity
Any process in which a protein is transported to, or maintained in, a specific location.
asymmetric protein localisation
asymmetric protein localization
cellular protein localisation
cellular protein localization
channel localizer activity
establishment and maintenance of asymmetric protein localization
establishment and maintenance of protein localization
protein localisation
Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or ketone + NADPH + H+.
alcohol:NADP dehydrogenase activity
aldehyde reductase (NADPH) activity
NADP-aldehyde reductase activity
Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate.
acetic ester hydrolase activity
acetic-ester acetylhydrolase activity
C-esterase (in animal tissues)
chloroesterase
citrus acetylesterase
p-nitrophenyl acetate esterase
Catalysis of the reaction: a primary methyl amine + H2O + O2 = an aldehyde + H2O2 + NH4+.
amine oxidase (copper-containing) activity
amine oxidase activity
primary amine oxidase activity
primary-amine:oxygen oxidoreductase (deaminating) activity  systematic_synonym
Binding to a transcription factor, a protein required to initiate or regulate transcription.
TF binding
transcription regulator binding
Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.
translation factor activity, nucleic acid binding
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
dual-specificity protein phosphatase
Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.
sulphotransferase activity
A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
biological process
physiological process
single organism process
single-organism process
A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well  macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
metabolism
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.
DNA replication inhibitor
down regulation of DNA replication
down-regulation of DNA replication
downregulation of DNA replication
inhibition of DNA replication
Catalysis of the transfer of a methyl group to an acceptor molecule.
methylase
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction.
ATPase activity, acting on RNA
ATPase, acting on RNA
RNA-dependent adenosinetriphosphatase activity
RNA-dependent ATPase activity
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
steroid metabolism
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
cholesterol metabolism
The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light.
ergosterol metabolism
The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development.
ecdysone metabolism
The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
bile acid metabolism
The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
C21-steroid hormone metabolism
The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
C21-steroid hormone breakdown
C21-steroid hormone catabolism
C21-steroid hormone degradation
The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
androgen metabolism
The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
estrogen metabolism
oestrogen metabolic process
oestrogen metabolism
The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
glucocorticoid metabolism
glucocorticosteroid metabolic process
glucocorticosteroid metabolism
The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance.
mineralocorticoid metabolism
The addition of an alkyl group to a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom.
protein amino acid alkylation
The removal of an alkyl group from a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom.
protein amino acid dealkylation
The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.
spermine metabolism
The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane.
spermidine metabolism
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
blood pressure homeostasis
blood pressure regulation
control of blood pressure
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
accidental cell death
necrosis
Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
amine receptor activity, G-protein coupled
biogenic amine receptor
G-protein coupled amine receptor activity
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
hydrolase, acting on peptide bonds
peptidase activity, acting on D-amino acid peptides
peptidase activity, acting on L-amino acid peptides
peptide hydrolase activity
protease activity
proteinase activity
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
cysteine protease activity
thiol protease activity
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
serine protease activity
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
metalloprotease activity
metalloproteinase activity
Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.
exoprotease activity
Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes.
peptidase activity, acting on peptides containing modified amino acids
Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule.
tRNA-adenosine deaminase activity
Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.
acid nucleotidase activity
deoxyinosine-activated nucleotidase (DIAN)
deoxyribonucleoside-activated nucleotidase (DAN)
NSP I
NSP II
nucleotide phosphohydrolase activity
nucleotide-specific phosphatase activity
Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
5\' nucleotidase activity
5\'-adenylic phosphatase
5\'-AMP nucleotidase
5\'-AMPase
5\'-mononucleotidase activity
5\'-ribonucleotide phosphohydrolase activity
adenosine 5\'-phosphatase
adenosine monophosphatase
AMP phosphatase
AMP phosphohydrolase
AMPase
snake venom 5\'-nucleotidase
thimidine monophosphate nucleotidase
UMPase
uridine 5\'-nucleotidase
Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.
G/T-mismatch-specific thymine-DNA glycosylase activity
Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
secondary active sulphate transmembrane transporter activity
sulfate porter activity
sulphate porter activity
Catalysis of the transfer of a methyl group (CH3-) to a protein.
protein methylase activity
Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
regulation of G protein coupled receptor protein signaling pathway
regulation of G protein coupled receptor protein signalling pathway
regulation of G-protein coupled receptor protein signaling pathway
regulation of G-protein coupled receptor protein signalling pathway
regulation of G-protein-coupled receptor protein signalling pathway
regulation of GPCR protein signaling pathway
regulation of GPCR protein signalling pathway
A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
14S cohesin
9S cohesin
cohesin core heterodimer
nuclear cohesin complex
SMC complex
SMC/kleisin ring complex
Smc1-Smc3 complex
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cell proliferation
Any process that activates or increases the rate or extent of cell proliferation.
activation of cell proliferation
positive regulation of cell proliferation
stimulation of cell proliferation
up regulation of cell proliferation
up-regulation of cell proliferation
upregulation of cell proliferation
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
down regulation of cell proliferation
down-regulation of cell proliferation
downregulation of cell proliferation
inhibition of cell proliferation
negative regulation of cell proliferation
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
daf-2 receptor signaling pathway
insulin receptor signalling pathway
The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.
acetylcholine metabolism
The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline.
acetylcholine anabolism
acetylcholine biosynthesis
acetylcholine formation
acetylcholine synthesis
The series of molecular signals initiated by an extracellular ligand binding to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
torso signalling pathway
The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.
spermidine anabolism
spermidine biosynthesis
spermidine formation
spermidine synthesis
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule.
3\'-5\' exodeoxyribonuclease activity
3\'-5\'-exodeoxyribonuclease activity
Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule.
single-stranded DNA specific exodeoxyribonuclease activity
ssDNA-specific exodeoxyribonuclease activity
Any process in which mRNA is transported to, or maintained in, a specific location within the cell.
establishment and maintenance of intracellular RNA localization
intracellular mRNA localisation
intracellular mRNA positioning
mRNA localization, intracellular
mRNA positioning, intracellular
The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
isoprenoid anabolism
isoprenoid biosynthesis
isoprenoid formation
isoprenoid synthesis
polyisoprenoid anabolism
polyisoprenoid biosynthesis
polyisoprenoid biosynthetic process
polyisoprenoid formation
polyisoprenoid synthesis
polyterpene biosynthesis
polyterpene biosynthetic process
The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
isoprenoid breakdown
isoprenoid catabolism
isoprenoid degradation
polyisoprenoid breakdown
polyisoprenoid catabolic process
polyisoprenoid catabolism
polyisoprenoid degradation
polyterpene catabolic process
polyterpene catabolism
The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
DNA bending activity
DNA bending involving DNA binding
A protein complex that contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes.
cysteine-type endopeptidase complex
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
laminin receptor protein
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
classical conditioning
conditional learning
conditional response
Pavlovian conditioning
Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-dependent ion-selective channel activity
voltage-gated anion channel activity
voltage-gated ion-selective channel activity
Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule.
double-stranded DNA specific exodeoxyribonuclease activity
The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I.
meiotic cell cycle G2/MI phase transition
meiotic G2/MI phase transition
meiotic G2/MI transition
Enables the transfer of a protein from one side of a membrane to the other.
protein channel activity
Enables the transfer of cation from one side of a membrane to the other.
cation transmembrane transporter activity
transmembrane cation transporter activity
The chemical reactions and pathways involving an mRNA encoding a histone.
histone mRNA metabolism
stem-loop-containing histone mRNA 3\'-end processing
Locomotory behavior in a fully developed and mature organism.
adult locomotory behaviour
Locomotory behavior in a larval (immature) organism.
larval locomotory behaviour
The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
glia cell migration
Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.
attenuation of antimicrobial humoral response
down regulation of antimicrobial humoral response
down-regulation of antimicrobial humoral response
downregulation of antimicrobial humoral response
inhibition of antimicrobial humoral response
Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.
MAP4K activity
MAPKKKK
Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.
-subunit kinase activity
CTD kinase activity
RNA polymerase II carboxy-terminal domain kinase activity
RNA polymerase subunit kinase activity
RNA-polymerase-subunit kinase activity
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
germ-cell migration
pole cell migration
primordial germ cell migration
The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
asymmetric cytokinesis
asymmetrical cell division
asymmetrical cytokinesis
Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location.
regulation of bicoid mRNA localisation
Any process that modulates the size of a cell.
cell size control
Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster.
larval cuticle anabolism
larval cuticle biosynthetic process
larval cuticle formation
larval cuticle synthesis
Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster.
adult chitin-based cuticle anabolism
adult chitin-based cuticle biosynthetic process
adult chitin-based cuticle formation
adult chitin-based cuticle synthesis
adult cuticle anabolism
adult cuticle biosynthetic process
adult cuticle formation
adult cuticle synthesis
Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.
cellular axon ensheathment
cellular nerve ensheathment
nerve ensheathment
Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar.
GlcNAc transferase activity
Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide.
GalNAc transferase activity
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
pre-mRNA splicing factor activity
Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress.
mechanically gated channel activity
mechanically-gated channel activity
mechanically-gated ion channel activity
mechanosensitive ion channel activity
Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O.
cytochrome P450 CYP2A12
Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water.
arachidonic acid monooxygenase activity
cytochrome P450 CYP2B19
Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid.
arachidonic acid epoxygenase activity
cytochrome P450 CYP2J5
cytochrome P450 CYP2J6
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
cytochrome P450 CYP2G1
olfactory-specific steroid hydroxylase activity
Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O.
cytochrome P450 CYP7B1
Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O.
cytochrome P450 CYP8B1