NothingMuch/GO-Terms huggingface dataset:
Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of astral microtubules.
astral microtubule stabilization
Binding to and responding, e.g. by conformational change, to changes in the cellular level of a sterol.
sterol sensing activity
sterol-sensing domain
A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed.
Sre1-Scp1 complex
Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
activation of translation in response to oxidative stress
stimulation of translation in response to oxidative stress
up regulation of translation in response to oxidative stress
up-regulation of translation in response to oxidative stress
upregulation of translation in response to oxidative stress
Catalysis of the reaction: 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + ADP + H+.
1D-myo-inositol-tetrakisphosphate 2-kinase activity
inositol tetrakisphosphate 2-kinase activity
inositol-tetrakisphosphate 2-kinase activity
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.
negative regulation of inositol trisphosphate anabolism
negative regulation of inositol trisphosphate biosynthesis
negative regulation of inositol trisphosphate formation
negative regulation of inositol trisphosphate synthesis
negative regulation of IP3 biosynthesis
negative regulation of IP3 biosynthetic process
negative regulation of myo-inositol trisphosphate biosynthesis
negative regulation of myo-inositol trisphosphate biosynthetic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.
positive regulation of inositol trisphosphate anabolism
positive regulation of inositol trisphosphate biosynthesis
positive regulation of inositol trisphosphate formation
positive regulation of inositol trisphosphate synthesis
positive regulation of IP3 biosynthesis
positive regulation of IP3 biosynthetic process
positive regulation of myo-inositol trisphosphate biosynthesis
positive regulation of myo-inositol trisphosphate biosynthetic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
negative regulation of collagen anabolism
negative regulation of collagen biosynthesis
negative regulation of collagen formation
negative regulation of collagen synthesis
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
positive regulation of collagen anabolism
positive regulation of collagen biosynthesis
positive regulation of collagen formation
positive regulation of collagen synthesis
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
positive regulation of gene-specific transcription elongation from RNA polymerase II promoter
positive regulation of RNA elongation from RNA polymerase II promoter
positive regulation of transcription elongation from RNA polymerase II promoter
A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling.
endosomal adaptor complex
MP1-p14 scaffolding complex
The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process.
mAST release from mitochondria
release of aspartate aminotransferase from mitochondria
The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix.
insertion of proteins into the mitochondrial membrane from the inner side
protein insertion into mitochondrial inner membrane from matrix side
protein insertion into mitochondrial membrane from inner side
The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.
mitochondrial complex I assembly
mitochondrial NADH dehydrogenase complex (ubiquinone) assembly
A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE.
FceRI complex
IgE receptor complex
immunoglobulin E receptor complex
A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA.
FcaRI complex
IgA receptor complex
immunoglobulin A receptor complex
A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG.
FcgRI complex
IgG receptor complex
immunoglobulin G receptor complex
A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG.
FcgRIII complex
IgG receptor complex
immunoglobulin G receptor complex
Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response.
negative regulation of mast cell activation during immune response
Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response.
positive regulation of mast cell activation during immune response
A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.
axoglial septate junction
paranodal axoglial junction
paranodal septate junction
The chemical reactions and pathways resulting in the formation of cyclopentanol.
cyclopentanol anabolism
cyclopentanol biosynthesis
cyclopentanol formation
cyclopentanol synthesis
The chemical reactions and pathways resulting in the breakdown of cyclopentanol.
cyclopentanol breakdown
cyclopentanol catabolism
cyclopentanol degradation
Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process.
down regulation of mast cell apoptosis
down-regulation of mast cell apoptosis
downregulation of mast cell apoptosis
inhibition of mast cell apoptosis
negative regulation of mast cell apoptosis
Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process.
activation of mast cell apoptosis
positive regulation of mast cell apoptosis
stimulation of mast cell apoptosis
up regulation of mast cell apoptosis
up-regulation of mast cell apoptosis
upregulation of mast cell apoptosis
Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process.
down regulation of neutrophil apoptosis
down-regulation of neutrophil apoptosis
downregulation of neutrophil apoptosis
inhibition of neutrophil apoptosis
negative regulation of neutrophil apoptosis
Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process.
activation of neutrophil apoptosis
positive regulation of neutrophil apoptosis
stimulation of neutrophil apoptosis
up regulation of neutrophil apoptosis
up-regulation of neutrophil apoptosis
upregulation of neutrophil apoptosis
The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicycloheptane-2-carboxylic acid.
clavulanic acid anabolism
clavulanic acid biosynthesis
clavulanic acid formation
clavulanic acid synthesis
The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group.
aminophosphonate metabolism
The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid.
D-glutamine metabolism
The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid.
D-glutamate metabolism
The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid.
D-arginine metabolism
The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid.
D-ornithine metabolism
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof.
BCDX2 complex
A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast.
DX2 complex
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof.
CX3 complex
Rad55-Rad57 complex
Rhp55-Rhp57 complex
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof.
BC complex
The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity.
ansamycin anabolism
ansamycin biosynthesis
ansamycin formation
ansamycin synthesis
The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44--3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)oxadiazacyclohexadecinobenzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria.
vancomycin anabolism
vancomycin biosynthesis
vancomycin formation
vancomycin synthesis
Any process that stops, prevents, or reduces the frequency, rate or extent of extrathymic T cell differentiation.
negative regulation of extrathymic T cell development
Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus.
negative regulation of thymic T cell proliferation
negative regulation of thymocyte cell proliferation
negative regulation of thymocyte proliferation
Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation.
positive regulation of extrathymic T cell development
Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus.
positive regulation of thymic T cell proliferation
positive regulation of thymocyte cell proliferation
positive regulation of thymocyte proliferation
Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O. The enzymatic part of the reaction produces 4-aminobutanal that spontaneously cyclizes to form 1-pyrroline.
butane-1,4-diamine:2-oxoglutarate aminotransferase activity
PAT activity
putrescine aminotransferase activity
putrescine transaminase activity
putrescine-alpha-ketoglutarate transaminase activity
putrescine:2-oxoglutarate aminotransferase activity
putrescine:alpha-ketoglutarate aminotransferase activity
YgjG
The portion of the plasma membrane surrounding a cellular bud.
cellular bud plasma membrane
The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
protein secretion by the T6SS
protein secretion by the type VI protein secretion system
type VI protein secretion system
A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence.
T6SS complex
The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome.
chlorosome membrane
Either of the two lipid bilayers surrounding a Cvt vesicle, a vesicle that functions in the cytoplasm-to-vacuole targeting (Cvt) pathway.
cytoplasm to vacuole targeting vesicle membrane
cytoplasm-to-vacuole targeting vesicle membrane
The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
ER-Golgi intermediate compartment membrane
Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.
down regulation of glucokinase activity
down-regulation of glucokinase activity
downregulation of glucokinase activity
glucokinase inhibitor
inhibition of glucokinase activity
Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.
glucokinase activator
stimulation of glucokinase activity
up regulation of glucokinase activity
up-regulation of glucokinase activity
upregulation of glucokinase activity
Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
down regulation of serine phosphorylation of STAT3 protein
down-regulation of serine phosphorylation of STAT3 protein
downregulation of serine phosphorylation of STAT3 protein
inhibition of serine phosphorylation of STAT3 protein
negative regulation of serine phosphorylation of STAT3 protein
Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
activation of serine phosphorylation of STAT3 protein
positive regulation of serine phosphorylation of STAT3 protein
up regulation of serine phosphorylation of STAT3 protein
up-regulation of serine phosphorylation of STAT3 protein
upregulation of serine phosphorylation of STAT3 protein
Binding to a nuclear progesterone receptor.
progesterone receptor binding
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
negative regulation of estrogen receptor signaling pathway
negative regulation of estrogen receptor signalling pathway
Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
positive regulation of estrogen receptor signaling pathway
positive regulation of estrogen receptor signalling pathway
The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
T cell receptor V(D)J joining
T cell receptor V-D-J joining
T cell receptor V-D-J recombination
T cell receptor V-J joining
T cell receptor V-J recombination
T-cell receptor V(D)J recombination
TCR V(D)J recombination
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in).
ATP-dependent oligogalacturonide transmembrane transporter activity
ATPase-coupled oligogalacturonide transmembrane transporter activity
oligogalacturonide transmembrane transporter activity
oligogalacturonide transporting ATPase activity
oligogalacturonide-transporting ATPase activity
Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase.
MAPKKKK binding
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.
argonaute siRNA chaperone complex
The proteinaceous structure surrounding a gas vesicle.
gas vesicle membrane
gas vesicle wall
A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively.
dolichyl-phosphate beta-D-mannosyltransferase complex
DPM synthase complex
A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48.
chromatin assembly factor 1 complex
Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin.
ceramide:phosphatidylcholine cholinephosphotransferase activity
phosphatidylcholine:ceramide cholinephosphotransferase activity
SM synthase activity
SMS1
SMS2
Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.
Ca2+/CaM-dependent protein phosphatase activity
calcineurin activity
calcium- and calmodulin-dependent protein phosphatase activity
calcium/calmodulin-dependent protein phosphatase activity
A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast.
SAPHIRE complex
Swm complex
Swm1/2 complex
Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O.
TXNPx activity
Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = ADP + 4,5-bisdiphosphoinositol-1D-myo-inositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = ADP + 5,6-bisdiphosphoinositol-1D-myo-inositol (1,2,3,4)tetrakisphosphate.
diphosphoinositol-pentakisphosphate 5-kinase activity
inositol heptakisphosphate 5-kinase activity
IP7 5-kinase activity
Binding to RNA subunit of ribonuclease P.
RNase P RNA binding
Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide.
Sda beta 1,4GalNAc transferase
UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity
The series of molecular signals initiated by adiponectin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
adipocytokine signaling pathway
adiponectin-mediated signaling pathway
adiponectin-mediated signalling pathway
A process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins.
iron assimilation by reduction and transport
Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in).
ATP-dependent urea transmembrane transporter activity
carbamide-transporting ATPase activity
urea-transporting ATPase activity
The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2-phosphonoethylamine transport
ciliatine transport
Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other by catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in).
2-aminoethylphosphonate transmembrane transporter activity
2-aminoethylphosphonate transporting ATPase activity
2-aminoethylphosphonate-transporting ATPase activity
2-phosphonoethylamine transmembrane transporter activity
2-phosphonoethylamine transporting ATPase activity
ATP-dependent 2-aminoethylphosphonate transporter activity
ciliatine transporter activity
ciliatine transportingATPase activity
Binding to 2-aminoethylphosphonate.
2-phosphonoethylamine binding
ciliatine binding
The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region.
cysteine export
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-cysteine(in) = ADP + H+ + L-cysteine(out) + phosphate.
ATP-dependent cysteine transporter activity
ATPase-coupled cysteine transmembrane transporter activity
ATPase-coupled cysteine transporter activity
cysteine exporter
cysteine-exporting ATPase activity
cysteine-transporting ATPase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out).
ATP-dependent D-methionine transporter activity
ATP-dependent methionine transmembrane transporter activity
ATPase-coupled D-methionine transporter activity
ATPase-coupled methionine transmembrane transporter activity
D-methionine exporter
D-methionine importer
D-methionine transmembrane transporter activity
D-methionine transporter activity
D-methionine-exporting ATPase activity
D-methionine-importing ATPase activity
D-methionine-transporting ATPase activity
methionine transmembrane-transporting ATPase activity
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.
negative regulation of sumoylation
Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein.
positive regulation of sumoylation
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
negative regulation of penicillin breakdown
negative regulation of penicillin catabolism
negative regulation of penicillin degradation