NothingMuch/GO-Terms huggingface dataset:
Any process that activates or increases the activity of an enzyme.
activation of enzyme activity
activation of metalloenzyme activity
positive regulation of enzyme activity
positive regulation of metalloenzyme activity
stimulation of enzyme activity
stimulation of metalloenzyme activity
up regulation of enzyme activity
up regulation of metalloenzyme activity
up-regulation of enzyme activity
up-regulation of metalloenzyme activity
upregulation of enzyme activity
upregulation of metalloenzyme activity
Any process that stops or reduces the activity of an enzyme.
down regulation of enzyme activity
down regulation of metalloenzyme activity
down-regulation of enzyme activity
down-regulation of metalloenzyme activity
downregulation of enzyme activity
downregulation of metalloenzyme activity
inhibition of enzyme activity
inhibition of metalloenzyme activity
negative regulation of enzyme activity
negative regulation of metalloenzyme activity
Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of ARF GTPase activity
regulation of Cdc42 GTPase activity
regulation of Rab GTPase activity
regulation of Rac GTPase activity
regulation of Ral GTPase activity
regulation of Ran GTPase activity
regulation of Rap GTPase activity
regulation of Ras GTPase activity
regulation of Rho GTPase activity
A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells.
cytokinesis by binary fission
prokaryote-type cytokinesis
prokaryotic fission
Any process that generates purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis.
purine base salvage
Any process that generates pyrimidine nucleobases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis.
pyrimidine base salvage
Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis.
purine salvage
Binding to replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription.
RFB binding
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected.
negative regulation of DNA replication at replication fork barrier
replication fork blocking
replication fork stalling
The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
receptor metabolism
Any process that reduces the extent to which blood vessels can be pervaded by fluid.
down regulation of vascular permeability
down-regulation of vascular permeability
downregulation of vascular permeability
inhibition of vascular permeability
Any process that increases the extent to which blood vessels can be pervaded by fluid.
activation of vascular permeability
stimulation of vascular permeability
up regulation of vascular permeability
up-regulation of vascular permeability
upregulation of vascular permeability
Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
neurotrophic factor binding
neurotrophin 3 binding
neurotrophin 4/5 binding
neurotrophin TRK receptor activity
neurotrophin TRKA receptor activity
neurotrophin TRKB receptor activity
neurotrophin TRKC receptor activity
neurotrophin-3 binding
neurotrophin-4/5 binding
NT 4/5 binding
NT-3 binding
NT-4 binding
NT-4/5 binding
NT-5 binding
NT3 binding
NT4 binding
NT5 binding
Any process that modulates the canonical NF-kappaB signaling cascade.
regulation of I-kappaB kinase/NF-kappaB cascade
regulation of I-kappaB kinase/NF-kappaB signaling
Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid.
regulation of liquid surface tension
regulation of surface tension of a liquid
surfactant activity
The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH.
NAD (oxidized) transport
NAD (reduced) transport
NADH transport
nicotinamide adenine dinucleotide transport
oxidized NAD transport
oxidized nicotinamide adenine dinucleotide transport
reduced NAD transport
reduced nicotinamide adenine dinucleotide transport
Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.
Okazaki initiator RNA removal
Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.
3\' to 5\' DNA helicase activity
ATP-dependent 3\' to 5\' DNA helicase activity
ATP-dependent 3\'-5\' DNA helicase activity
The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.
actin cable assembly
actin cable formation
stress fibre biosynthesis
stress fibre formation
Any process that stops, prevents, or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis.
down regulation of photosynthesis, light reaction
down-regulation of photosynthesis, light reaction
downregulation of photosynthesis, light reaction
inhibition of photosynthesis, light reaction
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
proteasomal pathway
proteasomal processing
proteasomal ubiquitin-dependent protein breakdown
proteasomal ubiquitin-dependent protein catabolic process
proteasomal ubiquitin-dependent protein catabolism
proteasomal ubiquitin-dependent protein degradation
proteasome pathway
The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.
ubiquitin-dependent protein breakdown via the multivesicular body pathway
ubiquitin-dependent protein catabolic process via the MVB pathway
ubiquitin-dependent protein catabolism via the MVB pathway
ubiquitin-dependent protein degradation via the multivesicular body pathway
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present.
cell envelope organisation
cell envelope organization and biogenesis
Binding to an ion, a charged atoms or groups of atoms.
atom binding
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
biopolymer metabolic process
macromolecule metabolism
multicellular organismal macromolecule metabolic process
organismal macromolecule metabolism
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
peptide breakdown
peptide catabolism
peptide degradation
The process of transporting a substance into, and confining within, a vacuole.
retention in vacuole
sequestering in vacuole
sequestration in vacuole
storage in vacuole
vacuolar retention
vacuolar sequestration
vacuolar storage
A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes.
germline granule
nuage
polar granule
A multisubunit complex that catalyzes the acetylation of histones H4 and H2A.
H4/H2A HAT complex
A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
ABC-type efflux permease complex
ABC-type efflux porter complex
ABC-type uptake permease complex
mating pheromone exporter
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
bouton
presynaptic bouton
synaptic bouton
terminal button
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
branched dendritic spine
dendrite spine
mushroom dendritic spine
sessile dendritic spine
stubby dendritic spine
thin dendritic spine
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
response to amino acid stimulus
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-leucine stimulus.
response to leucine
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
astrocyte sheath
oligodendrocyte myelin sheath
Schwann cell myelin sheath
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates and their derivatives across a membrane.
ATP-dependent carbohydrate transmembrane transporter activity
ATPase-coupled carbohydrate transmembrane transporter activity
carbohydrate ABC transporter
carbohydrate-transporting ATPase activity
The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath.
myelin sheath maintenance
The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs.
oligodendrocyte compact myelin
Schwann cell compact myelin
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in).
anion ABC transporter
anion transmembrane-transporting ATPase activity
anion-transporting ATPase activity
ATP-dependent anion transmembrane transporter activity
ATPase-coupled anion transmembrane transporter activity
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
membrane-enclosed organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
biological condensate
membrane-less organelle
non-membrane-bounded organelle
non-membrane-enclosed organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular membrane-enclosed organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular non-membrane-bounded organelle
intracellular non-membrane-enclosed organelle
Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells.
laminin-2 binding
laminin-4 binding
Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
down regulation of protein complex disassembly
down-regulation of protein complex disassembly
downregulation of protein complex disassembly
inhibition of protein complex disassembly
negative regulation of protein complex disassembly
Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
activation of protein complex disassembly
positive regulation of protein complex disassembly
stimulation of protein complex disassembly
up regulation of protein complex disassembly
up-regulation of protein complex disassembly
upregulation of protein complex disassembly
Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
regulation of protein complex disassembly
Any process that occur in response to the presence of critically short or damaged telomeres.
DNA damage response, telomere maintenance
The aggregation, arrangement and bonding together of a mature, active proteasome complex.
26S proteasome assembly
proteasome complex assembly
proteasome maturation
A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
RBC maturation
red blood cell maturation
Any process that modulates the frequency, rate or extent of protein complex assembly.
regulation of protein complex assembly
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates.
regulation of carbohydrate anabolism
regulation of carbohydrate biosynthesis
regulation of carbohydrate formation
regulation of carbohydrate synthesis
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell.
extracellular non-membrane-bounded organelle
extracellular non-membrane-enclosed organelle
Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of K+ conductance
regulation of K+ transport
regulation of potassium conductance
regulation of potassium ion conductance
regulation of potassium transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
down regulation of potassium ion transport
down-regulation of potassium ion transport
downregulation of potassium ion transport
inhibition of potassium ion transport
negative regulation of K+ transport
negative regulation of potassium ion conductance
negative regulation of potassium transport
regulation of K+ conductance
regulation of potassium conductance
transmembrane conductance regulator activity
Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
activation of potassium ion transport
positive regulation of K+ conductance
positive regulation of K+ transport
positive regulation of potassium conductance
positive regulation of potassium ion conductance
positive regulation of potassium transport
stimulation of potassium ion transport
up regulation of potassium ion transport
up-regulation of potassium ion transport
upregulation of potassium ion transport
Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of ion transport
Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
activation of ion transport
stimulation of ion transport
up regulation of ion transport
up-regulation of ion transport
upregulation of ion transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
down regulation of ion transport
down-regulation of ion transport
downregulation of ion transport
inhibition of ion transport
negative regulation of ion transport
Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
detachment induced cell death
suspension induced apoptosis
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
apoptotic cell removal
efferocytosis
programmed cell clearance
The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid.
apo carotenoid metabolic process
apocarotenoid metabolism
The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid.
apo carotenoid biosynthetic process
apocarotenoid anabolism
apocarotenoid biosynthesis
apocarotenoid formation
apocarotenoid synthesis
The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid.
apo carotenoid catabolic process
apocarotenoid breakdown
apocarotenoid catabolism
apocarotenoid degradation
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
contractile fibre
A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.
apical cell junction complex
apical junction
The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents.
apical junction complex assembly
The regulated exocytosis of secretory granules by a leukocyte.
immune cell degranulation
immune cell granule exocytosis
leucocyte degranulation
leukocyte granule exocytosis
Any process that modulates the frequency, rate, or extent of leukocyte degranulation.
regulation of immune cell degranulation
regulation of immune cell granule exocytosis
regulation of leucocyte degranulation
regulation of leukocyte granule exocytosis
Any process that stops, prevents, or reduces the rate of leukocyte degranulation.
down regulation of leukocyte degranulation
down-regulation of leukocyte degranulation
downregulation of leukocyte degranulation
inhibition of leukocyte degranulation
negative regulation of immune cell degranulation
negative regulation of leucocyte degranulation
Any process that activates or increases the frequency, rate or extent of leukocyte degranulation.
activation of leukocyte degranulation
positive regulation of immune cell degranulation
positive regulation of leucocyte degranulation
stimulation of leukocyte degranulation
up regulation of leukocyte degranulation
up-regulation of leukocyte degranulation
upregulation of leukocyte degranulation
The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.
mast cell granule exocytosis
Any process that modulates the frequency, rate, or extent of mast cell degranulation.
regulation of mast cell granule exocytosis
Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
activation of mast cell degranulation
positive regulation of mast cell granule exocytosis
stimulation of mast cell degranulation
up regulation of mast cell degranulation
up-regulation of mast cell degranulation
upregulation of mast cell degranulation
The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil.
eosinophil granule exocytosis
Any process that modulates the frequency, rate, or extent of eosinophil degranulation.
regulation of eosinophil granule exocytosis
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
heterophil degranulation
neutrophil granule exocytosis
Any process that modulates the frequency, rate, or extent of neutrophil degranulation.
regulation of neutrophil granule exocytosis
The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell.
cytotoxic T cell granule exocytosis
cytotoxic T lymphocyte degranulation
cytotoxic T lymphocyte granule exocytosis
cytotoxic T-cell degranulation
cytotoxic T-cell granule exocytosis
cytotoxic T-lymphocyte degranulation
cytotoxic T-lymphocyte granule exocytosis
Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation.
regulation of cytotoxic T cell granule exocytosis
regulation of cytotoxic T lymphocyte degranulation
regulation of cytotoxic T lymphocyte granule exocytosis
regulation of cytotoxic T-cell degranulation
regulation of cytotoxic T-cell granule exocytosis
regulation of cytotoxic T-lymphocyte degranulation
regulation of cytotoxic T-lymphocyte granule exocytosis