NothingMuch/GO-Terms huggingface dataset:
Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid.
histidine/arginine/lysine/ornithine porter activity
L-lysine permease
lysine permease activity
Enables the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid.
L-methionine transporter activity
Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid.
L-threonine permease activity
L-threonine transporter activity
threonine/serine:sodium symporter activity
Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid.
L-tryptophan permease activity
L-tryptophan transporter activity
valine/tyrosine/tryptophan permease activity
Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid.
betaine transmembrane transporter activity
betaine/GABA:sodium symporter activity
glycine betaine/proline porter activity
proline/glycine/betaine:hydrogen/sodium symporter activity
Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other.
amine/amide/polyamine channel activity
Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2.
urea transporter activity
Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other.
uracil/uridine permease activity
Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other.
uracil/uridine permease activity
Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
amino acid/choline transmembrane transporter activity
choline permease activity
Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
vitamin Bt transporter activity
Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane.
acylcarnitine transporter activity
Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
coenzyme A transporter activity
Enables the transfer of heme from one side of a membrane to the other.
haem transporter activity
heme transporter activity
Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver.
thiamin permease activity
thiamin transmembrane transporter activity
thiamin uptake transporter activity
thiamine permease activity
thiamine uptake transmembrane transporter activity
vitamin B1 transporter activity
Enables the transfer of cycloheximide from one side of a membrane to the other. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes.
cycloheximide transporter activity
Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections.
fluconazole transporter activity
Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
fatty acid transporter activity
fatty acyl transporter activity
fatty-acyl group transporter activity
peroxisomal fatty acyl transporter
Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group.
aminophospholipid transmembrane transporter activity
aminophospholipid transporter activity
Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
hydrogen ion channel activity
Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
alpha-type channel activity
channel-forming toxin activity
channel/pore class transporter activity
nonselective channel activity
pore activity
pore class transporter activity
substrate-specific channel activity
Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching.
stretch-activated, cation-selective, calcium channel activity
Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
ionotropic receptor activity
ligand-gated ion channel activity
Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
calcium-release channel activity
intracellular ligand-gated calcium channel activity
Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
acid-sensing ion channel activity
amiloride-sensitive sodium channel activity
ASIC activity
epithelial sodium channel
Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
outer membrane exporter porin
porin
Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters.
active transporter
coupled carrier
electrochemical potential-driven transporter activity
energizer of outer membrane receptor-mediated transport activity
galactose/glucose (methylgalactoside) porter activity
heavy metal ion porter activity
ion-gradient-driven energizer activity
multidrug endosomal transmembrane transporter activity
nitrite/nitrate porter activity
porter activity
porters
secondary carrier-type facilitators
Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species.
facilitated diffusion carrier
single-species transporter activity
uniport
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
cotransporter activity
porter activity
symport
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).
solute:cation symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in).
heavy metal ion:hydrogen symporter activity
high affinity metal ion uptake transporter activity
L-idonate/D-gluconate:hydrogen symporter activity
low affinity metal ion uptake transporter activity
proline/glycine/betaine:hydrogen/sodium symporter activity
solute:hydrogen symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).
anion:cation symporter activity
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
antiport
countertransporter activity
exchange transporter activity
exchanger
ion antiporter activity
porter
solute:solute antiporter activity
solute:solute exchange
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + phosphate(in) = organophosphate(in) +  phosphate(out).
organophosphate:inorganic phosphate antiporter activity
Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon.
inorganic solute uptake transmembrane transporter activity
inorganic uptake permease activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in).
iron-siderophore transporter activity
siderochrome transporter activity
siderochrome-iron transporter activity
siderophore transmembrane transporter activity
siderophore transporter activity
siderophore-iron transporter activity
Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism.
monocarboxylate porter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in).
calcium:cation antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in).
proline/glycine/betaine:hydrogen/sodium symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic anion(out) + Na+(out) = monoatomic anion(in) + Na+(in).
anion:sodium symporter activity
monovalent anion:sodium symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in).
cation:chloride cotransporter activity
cation:chloride symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).
potassium ion symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
pH-dependent sodium:hydrogen antiporter activity
pH-dependent sodium:proton antiporter activity
sodium/hydrogen antiporter activity
sodium:hydrogen antiporter activity
sodium:hydrogen exchange activity
sodium:hydrogen exchanger
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in).
nucleobase:cation symporter activity
Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical such as ATP hydrolysis, redox energy and photon energy.
primary active transporter
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported.
ATP-dependent monosaccharide transmembrane transporter activity
ATPase-coupled monosaccharide transmembrane transporter activity
monosaccharide ABC transporter
monosaccharide-importing ATPase activity
monosaccharide-transporting ATPase activity
Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in).
ATP-dependent polyamine transmembrane transporter activity
ATPase-coupled polyamine transmembrane transporter activity
ATPase-coupled spermidine transmembrane transporter activity
polyamine ABC transporter
polyamine porter activity
polyamine-importing ATPase activity
polyamine-transporting ATPase activity
spermidine porter activity
spermidine-importing ATPase activity
Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H+ + phosphate + quaternary ammonium(in).
ATP-dependent quaternary-ammonium compound transmembrane transporting activity
ATPase-coupled quaternary ammonium compound transmembrane transporting activity
glycine betaine/proline porter activity
quarternary amine transporter activity
quaternary amine uptake transporter activity
quaternary-amine-transporting ATPase activity
quaternary-ammonium-compound ABC transporter
quaternary-ammonium-compound-transporting ATPase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in).
ABC-type oligosaccharide transporter
ATP-dependent oligosaccharide transmembrane transporter activity
ATPase-coupled oligosaccharide transmembrane transporter activity
oligosaccharide ABC transporter
oligosaccharide-transporting ATPase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out).
amino acid ABC transporter
amino acid-exporting ATPase activity
amino acid-importing ATPase activity
amino acid-transporting ATPase activity
ATP-dependent amino acid transmembrane transporter activity
ATPase-coupled amino acid transmembrane transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in).
ATP-dependent polar amino acid-transporter activity
cystine/diaminopimelate porter activity
glutamate/aspartate porter activity
histidine permease activity
histidine/arginine/lysine/ornithine porter activity
polar amino acid uptake transporter activity
polar amino acid-importing ATPase activity
polar-amino acid ABC transporter
polar-amino acid-importing ATPase activity
polar-amino acid-transporting ATPase activity
polar-amino-acid-transporting ATPase activity
Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria.
ATP-dependent peptide transmembrane transporter activity
ATPase-coupled peptide transmembrane transporter activity
peptide ABC transporter
peptide-transporting ATPase activity
Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.
P-P-bond-hydrolysis-driven protein transmembrane transporter activity
protein translocase activity
Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source.
decarboxylation-driven transporter
Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source.
oxidoreduction-driven transporter
Binds to and modulates the activity of a potassium channel.
potassium channel gating activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in).
melibiose permease activity
melibiose:cation symporter activity
melibiose:monovalent cation symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in).
aromatic amino acid:hydrogen symporter activity
Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.
formate uptake permease activity
formate uptake transmembrane transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in).
sodium/excitatory glutamate cotransporter activity
sodium/excitatory glutamate symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in).
nucleoside permease activity
nucleoside:hydrogen ion symporter activity
nucleoside:hydrogen symporter activity
Catalysis of the transfer of nitrite from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
nitrite uptake permease activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + phosphate(in) = hexose phosphate(in) +  phosphate(out).
hexose-phosphate:inorganic phosphate antiporter activity
Enables the transfer of 3-hydroxyphenyl propanoate from one side of a membrane to the other.
3-hydroxyphenyl propionate transmembrane transporter activity
Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
efflux permease activity
efflux transporter activity
monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
Enables the transfer of N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine.
N-acetylgalactosamine permease activity
Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.
D-GlcNAc transmembrane transporter activity
N-Acetyl-D-glucosamine permease
N-acetyl-D-glucosamine transmembrane transporter activity
N-acetylchitosamine transmembrane transporter activity
N-acetylglucosamine permease activity
Enables the transfer of beta-glucosides from one side of a membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration.
beta-glucoside permease activity
Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens.
trehalose permease activity
Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group.
mannitol permease activity
Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose.
glucitol permease activity
glucitol transporter activity
sorbitol permease activity
Enables the transfer of a galactitol from one side of a membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose.
galactitol permease activity
Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
mannose permease activity
Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.
short-chain fatty acid transporter activity
short-chain fatty acid uptake transporter activity
Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP.
fatty acid CoA ligase activity
fatty acyl-coenzyme A synthetase activity
fatty-acid ligase activity
Enables the transfer of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, from one side of a membrane to the other.
murein transporter activity
Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.
quaternary amine transmembrane transporter activity
quaternary ammonium compound transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in).
quaternary ammonium group:hydrogen symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in).
sodium:alanine symporter activity
Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings.
branched-chain aliphatic amino acid transmembrane transporter activity
branched-chain aliphatic amino acid transporter activity
leucine/valine/isoleucine permease activity
valine/tyrosine/tryptophan permease activity