NothingMuch/GO-Terms huggingface dataset:
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
lens development
lens development in camera-style eye
The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
lens morphogenesis
lens morphogenesis in camera-style eye
Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization.
down regulation of receptor internalization
down-regulation of receptor internalization
downregulation of receptor internalization
inhibition of receptor internalization
Any process that activates or increases the frequency, rate or extent of receptor internalization.
activation of receptor internalization
stimulation of receptor internalization
up regulation of receptor internalization
up-regulation of receptor internalization
upregulation of receptor internalization
Any process that alters the size or shape of an auditory receptor cell.
hair cell morphogenesis
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
calcium ion import
capacitative calcium entry
SOCE
store-operated calcium import
A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual.
aggression
The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
retinoic acid anabolic process
retinoic acid biosynthesis
The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
tRNA wobble uridine thiolation
wobble position s2U biosynthesis
The chemical reactions and pathways involving hypochlorous acid.
HClO metabolic process
HOCl metabolic process
hypochlorite metabolic process
hypochlorous acid metabolism
A nuclear receptor-mediated signaling pathway initiated by a thyroid hormone  binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
thyroid hormone mediated signalling pathway
Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway.
regulation of thyroid hormone mediated signaling pathway
regulation of thyroid hormone mediated signalling pathway
The hydrolysis of an incorrectly aminoacylated tRNA.
amino acid proofreading activity
aminoacyl-tRNA hydrolysis activity
The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response.
somatic recombination of antibody genes during immune response
somatic recombination of immunoglobulin genes during immune response
The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion.
gene conversion of antibody genes
The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response.
somatic diversification of antibodies during immune response
somatic diversification of immunoglobulins during immune response
A behavioral response seeking to protect an organism from an perceived external threat to that organism.
behavioural defense response
A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism.
physiological defense response to insect
A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
physiological defense response to nematode
The series of molecular signals initiated by a ligand binding to a cell surface receptor that leads to the activation of an innate immune response.
activation of innate immune response by cell surface receptor signaling pathway
innate immune response activating cell surface receptor signalling pathway
The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
pathogen receptor signaling pathway
pathogen receptor signalling pathway
PRR signaling pathway
The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
TLR signaling pathway
toll-like receptor signalling pathway
Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.
activation of antimicrobial peptide production
antimicrobial peptide induction
stimulation of antimicrobial peptide production
up regulation of antimicrobial peptide production
up-regulation of antimicrobial peptide production
upregulation of antimicrobial peptide production
The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines.
NK cell mediated immunity
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.
response to bacteria associated molecule
response to bacterial associated molecule
response to bacterium associated molecule
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.
response to fungus associated molecule
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin.
response to oomycetes associated molecule
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
haematopoietic progenitor cell differentiation
haemopoietic progenitor cell differentiation
hemopoietic progenitor cell differentiation
The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.
healing during inflammatory response
inflammatory response wound healing
The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared, as part of an inflammatory response.
connective tissue replacement during inflammatory response
fibrosis during inflammatory response
tissue fibrosis development
An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
acquired immune response
immune memory response
An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues.
immune response in organ or tissue
A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.
glandular kallikrein-kinin cascade
Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade.
down regulation of kinin cascade
down-regulation of kinin cascade
downregulation of kinin cascade
inhibition of kinin cascade
Any process that activates or increases the frequency, rate, or extent of the kinin cascade.
activation of kinin cascade
stimulation of kinin cascade
up regulation of kinin cascade
up-regulation of kinin cascade
upregulation of kinin cascade
A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
cell activation during immune response
A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
endothelial cell activation during immune response
A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.
immune cell activation during inflammatory response
leukocyte activation during inflammatory response
A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
plasmacytoid dendritic cell activation during immune response
A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.
myeloid leucocyte activation
A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
myeloid cell activation during immune response
A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.
basophil activation during immune response
The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
myeloid dendritic cell activation during immune response
The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
eosinophil activation during immune response
The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.
mast cell activation during immune response
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
macrophage activation during immune response
macrophage polarization involved in immune response
The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
neutrophil activation during immune response
A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
lymphocyte activation during immune response
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
T cell activation during immune response
T lymphocyte activation during immune response
T-cell activation during immune response
T-lymphocyte activation during immune response
The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
alpha-beta T cell activation during immune response
alpha-beta T lymphocyte activation during immune response
alpha-beta T-cell activation during immune response
alpha-beta T-lymphocyte activation during immune response
The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
natural killer T lymphocyte activation during immune response
natural killer T-cell activation during immune response
natural killer T-lymphocyte activation during immune response
NK T cell activation during immune response
NK T lymphocyte activation during immune response
NK T-cell activation during immune response
NK T-lymphocyte activation during immune response
The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
gamma-delta T cell activation during immune response
gamma-delta T lymphocyte activation during immune response
gamma-delta T-cell activation during immune response
gamma-delta T-lymphocyte activation during immune response
The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.
T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
T cell development involved in immune response
T cell differentiation during immune response
T lymphocyte differentiation during immune response
T-cell differentiation during immune response
T-lymphocyte differentiation during immune response
The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
alpha-beta T cell development involved in immune response
alpha-beta T cell differentiation during immune response
alpha-beta T lymphocyte differentiation during immune response
alpha-beta T-cell differentiation during immune response
alpha-beta T-lymphocyte differentiation during immune response
The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
CD4-positive, alpha-beta T cell development involved in immune response
CD4-positive, alpha-beta T cell differentiation during immune response
CD4-positive, alpha-beta T lymphocyte differentiation during immune response
CD4-positive, alpha-beta T-cell differentiation during immune response
CD4-positive, alpha-beta T-lymphocyte differentiation during immune response
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes.
T-helper cell fate commitment
Th0 lineage commitment
Thp lineage commitment
The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response.
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response
CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response
CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response
CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response
CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response
The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
alpha-beta intraepithelial T cell development
alpha-beta intraepithelial T lymphocyte differentiation
alpha-beta intraepithelial T-cell differentiation
alpha-beta intraepithelial T-lymphocyte differentiation
The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
gamma-delta intraepithelial T cell development
gamma-delta intraepithelial T lymphocyte differentiation
gamma-delta intraepithelial T-cell differentiation
gamma-delta intraepithelial T-lymphocyte differentiation
The expansion of a T cell population by cell division as part of an immune response.
T cell proliferation during immune response
T lymphocyte proliferation during immune response
T-cell proliferation during immune response
T-lymphocyte proliferation during immune response
The expansion of an alpha-beta T cell population by cell division as part of an immune response.
alpha-beta T cell proliferation during immune response
alpha-beta T lymphocyte proliferation during immune response
alpha-beta T-cell proliferation during immune response
alpha-beta T-lymphocyte proliferation during immune response
The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
B cell activation during immune response
B lymphocyte activation during immune response
B-cell activation during immune response
B-lymphocyte activation during immune response
The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response.
mature B cell development involved in immune response
mature B cell differentiation during immune response
mature B lymphocyte differentiation during immune response
mature B-cell differentiation during immune response
mature B-lymphocyte differentiation during immune response
The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
plasma cell development
The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
natural killer cell activation during immune response
NK cell activation during immune response
The expansion of a natural killer cell population by cell division as part of an immune response.
natural killer cell proliferation during immune response
NK cell proliferation during immune response
The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response.
natural killer cell development involved in immune response
natural killer cell differentiation during immune response
NK cell differentiation during immune response
The process in which a lymphoid progenitor cell becomes committed to become any type of B cell.
B lymphocyte lineage commitment
B-cell lineage commitment
B-lymphocyte lineage commitment
The process in which a precursor cell type acquires the specialized features of an immature B cell.
immature B cell development
immature B lymphocyte differentiation
immature B-cell differentiation
immature B-lymphocyte differentiation
The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.
pro-B cell development
pro-B lymphocyte differentiation
The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.
pre-B cell development
pre-B lymphocyte differentiation
The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent.
transitional stage B cell development
transitional stage B lymphocyte differentiation
transitional stage B-cell differentiation
transitional stage B-lymphocyte differentiation
The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.
mature B lymphocyte differentiation
mature B-cell differentiation
mature B-lymphocyte differentiation
mature cell development
The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival.
B lymphocyte selection
B-cell selection
B-lymphocyte selection
Any B cell selection process that occurs in the bone marrow.
central B lymphocyte selection
central B-cell selection
central B-lymphocyte selection
Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow.
central B lymphocyte anergy
central B-cell anergy
central B-lymphocyte anergy
The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection.
central B lymphocyte deletion
central B-cell deletion
central B-lymphocyte deletion
Any B cell selection process that occurs in the periphery.
peripheral B lymphocyte selection
peripheral B-cell selection
peripheral B-lymphocyte selection
The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
B lymphocyte affinity maturation
B-cell affinity maturation
B-lymphocyte affinity maturation