NothingMuch/GO-Terms huggingface dataset:
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out).
acridine efflux pump activity
acridine:hydrogen antiporter activity
The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase.
BCCP biosynthesis
BCCP biosynthetic process
biotin carboxyl carrier protein anabolism
biotin carboxyl carrier protein biosynthesis
biotin carboxyl carrier protein formation
biotin carboxyl carrier protein synthesis
Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine.
homoserine transporter activity
Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds.
1,3-1,4-beta-D-glucan 4-glucanohydrolase activity
1,3-1,4-beta-glucan 4-glucanohydrolase activity
1,3;1,4-beta-glucan 4-glucanohydrolase activity
1,3;1,4-beta-glucan endohydrolase activity
beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity
beta-glucanase activity
endo-beta-1,3-1,4 glucanase activity
lichenase activity
mixed linkage beta-glucanase activity
Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.
(1->3)-beta-glucan 3-glucanohydrolase activity
(1->3)-beta-glucan endohydrolase activity
1,3-beta-D-glucan 3-glucanohydrolase activity
1,3-beta-D-glucan glucanohydrolase activity
beta-1,3-glucanase
callase activity
endo-(1,3)-beta-D-glucanase activity
endo-(1->3)-beta-D-glucanase activity
endo-1,3-beta-D-glucanase
endo-1,3-beta-glucanase activity
endo-1,3-beta-glucosidase activity
kitalase activity
laminaranase activity
laminarinase activity
oligo-1,3-glucosidase activity
Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma.
PPAR binding
The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
activation of JAK protein
activation of JAK protein by tyrosine phosphorylation
activation of JAK1 kinase activity
activation of JAK1 protein
activation of JAK2 kinase activity
activation of JAK2 protein
positive regulation of JAK protein activity by tyrosine phosphorylation
tyrosine phosphorylation of JAK protein
tyrosine phosphorylation of JAK1 protein
tyrosine phosphorylation of JAK2 protein
Binds to and increases ornithine decarboxylase activity.
L-ornithine carboxy-lyase activator activity
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
down regulation of amyloid precursor protein biosynthetic process
down-regulation of amyloid precursor protein biosynthetic process
downregulation of amyloid precursor protein biosynthetic process
inhibition of amyloid precursor protein biosynthetic process
negative regulation of amyloid precursor protein anabolism
negative regulation of amyloid precursor protein biosynthesis
negative regulation of amyloid precursor protein formation
negative regulation of amyloid precursor protein synthesis
negative regulation of APP biosynthesis
negative regulation of APP biosynthetic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
activation of amyloid precursor protein biosynthetic process
positive regulation of amyloid precursor protein anabolism
positive regulation of amyloid precursor protein biosynthesis
positive regulation of amyloid precursor protein formation
positive regulation of amyloid precursor protein synthesis
positive regulation of APP biosynthesis
positive regulation of APP biosynthetic process
stimulation of amyloid precursor protein biosynthetic process
up regulation of amyloid precursor protein biosynthetic process
up-regulation of amyloid precursor protein biosynthetic process
upregulation of amyloid precursor protein biosynthetic process
Binding to X11-like protein, a neuron-specific adaptor protein.
X11L binding
The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers.
actin monomer retention
actin monomer sequestering
actin monomer sequestering activity
actin monomer sequestration
actin monomer storage
retention of actin monomers
sequestration of actin monomers
storage of actin monomers
Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
down regulation of Golgi to plasma membrane protein transport
down-regulation of Golgi to plasma membrane protein transport
downregulation of Golgi to plasma membrane protein transport
inhibition of Golgi to plasma membrane protein transport
Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
activation of Golgi to plasma membrane protein transport
stimulation of Golgi to plasma membrane protein transport
up regulation of Golgi to plasma membrane protein transport
up-regulation of Golgi to plasma membrane protein transport
upregulation of Golgi to plasma membrane protein transport
Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane.
down regulation of fusion of sperm to egg plasma membrane
down-regulation of fusion of sperm to egg plasma membrane
downregulation of fusion of sperm to egg plasma membrane
inhibition of fusion of sperm to egg plasma membrane
inhibition of sperm-oocyte fusion
negative regulation of sperm-oocyte fusion
Binding to the microtubule constituent protein alpha-tubulin.
alpha tubulin binding
Binding to the microtubule constituent protein gamma-tubulin.
gamma tubulin binding
A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires the cytosolic regulatory subunits at least NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2 for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2.
flavocytochrome b558
respiratory-burst oxidase
Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
caspase inhibitor activity
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis.
tRNA aminoacylation for nonribosomal peptide anabolism
tRNA aminoacylation for nonribosomal peptide biosynthesis
tRNA aminoacylation for nonribosomal peptide formation
tRNA aminoacylation for nonribosomal peptide synthesis
Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor.
amino acid adenylation by nonribosomal peptide synthase
amino acid adenylation by NRPS
The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative.
dolichyl monophosphate anabolism
dolichyl monophosphate biosynthesis
dolichyl monophosphate formation
dolichyl monophosphate synthesis
The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.
taxis in response to temperature stimulus
Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development.
exit from nematode dormancy
Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development.
maintenance of dormancy in the nematode
The directed movement of amino acids into a cell or organelle.
amino acid uptake
Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis.
adenine, hypoxanthine and their nucleoside salvage
guanine, xanthine and their nucleoside salvage
Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.
social gliding motility
TFP-dependent motility
TFP-dependent movement
twitching motility
type 4 pilus-dependent motility
type four pilus-dependent motility
Catalysis of the reaction: NAD+ + precorrin-2 = 2 H+ + NADH + sirohydrochlorin.
1,3-dimethyluroporphyrinogen III dehydrogenase activity
CysG
dihydrosirohydrochlorin dehydrogenase activity
Met8p
precorrin-2 oxidase activity
precorrin-2:NAD+ oxidoreductase activity
SirC
siroheme synthase activity
Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade.
activation of I-kappaB kinase/NF-kappaB cascade
positive regulation of I-kappaB kinase/NF-kappaB cascade
positive regulation of I-kappaB kinase/NF-kappaB signaling
stimulation of I-kappaB kinase/NF-kappaB cascade
up regulation of I-kappaB kinase/NF-kappaB cascade
up-regulation of I-kappaB kinase/NF-kappaB cascade
upregulation of I-kappaB kinase/NF-kappaB cascade
Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade.
down regulation of I-kappaB kinase/NF-kappaB cascade
down-regulation of I-kappaB kinase/NF-kappaB cascade
downregulation of I-kappaB kinase/NF-kappaB cascade
inhibition of I-kappaB kinase/NF-kappaB cascade
negative regulation of I-kappaB kinase/NF-kappaB cascade
negative regulation of I-kappaB kinase/NF-kappaB signaling
Binding to the protein-tyrosine kinase receptor ErbB-3/HER3.
HER3 receptor binding
Neu/ErbB-2 receptor activity
Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+.
PRPP pyrophosphatase activity
Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis.
5\' to 3\' DNA helicase activity
ATP-dependent 5\' to 3\' DNA helicase activity
ATP-dependent 5\'-3\' DNA helicase activity
DNA helicase IV activity
Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location.
establishment and maintenance of translational machinery localization
establishment and maintenance of translational protein localization
regulation of translation by machinery localisation
translational machinery localization
translational protein localization
The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional.
sno(s)RNA 3\' end cleavage
snoRNA 3\'-end cleavage
sRNA 3\'-end cleavage
The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination.
DNA synthesis during double-strand break repair via homologous recombination
The synthesis of DNA that contributes to the process of double-strand break repair via single-strand annealing.
DNA synthesis during double-strand break repair via single-strand annealing
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
photoentrainment of circadian clock
The cellular developmental process by which a cell becomes a heterocyst, a cell that carries out nitrogen fixation. This process involves changes to the cell wall, expression of nitrogenase and other proteins involved in nitrogen fixation, and degradation of photosystem II, which produces oxygen. This process is known to occur in some cyanobacteria.
heterocyst cell differentiation
heterocyst differentiation
heterocyst formation
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane.
1-2nm peptidoglycan-based cell wall biogenesis
cell wall anabolism
cell wall assembly
cell wall biosynthetic process
cell wall formation
cell wall synthesis
The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures.
cell outer membrane biogenesis
The process of transporting sodium ions into, and confining within, a vacuole.
sequestering of sodium ion (Na+) in vacuole
sequestration of sodium ion (Na+) in vacuole
sodium ion (Na+) retention in vacuole
sodium ion (Na+) storage in vacuole
vacuolar sequestering of sodium ion (Na+)
vacuolar sequestration of sodium ion (Na+)
vacuolar sodium ion (Na+) retention
vacuolar sodium ion (Na+) storage
Binding to a vascular endothelial growth factor receptor 1.
Flt-1 binding
VEGF receptor 1 binding
VEGFR 1 binding
Binding to a vascular endothelial growth factor receptor 2.
Flk-1 binding
KDR binding
kinase domain region binding
VEGF receptor 2 binding
VEGFR 2 binding
Binding to a vascular endothelial growth factor receptor 3.
fms-like-tyrosine kinase (Flt)-4 binding
VEGF receptor 3 binding
VEGFR 3 binding
Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
initial segment
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
trunk
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
cell soma cytoplasm
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out).
carbohydrate-exporting ATPase activity
Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate.
ABC-type bacteriocin transmembrane transporter activity
ATPase-coupled bacteriocin transmembrane transporter activity
bacteriocin ABC transporter
Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode.
oligodendrocyte paranodal termination
paranodal loop
Schwann cell paranodal termination
Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier.
Schmidt-Lanterman cleft
Binding to a protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization.
structural maintenance of chromosomes family protein binding
A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
cytoplasmic cullin complex
cytoplasmic SCF complex
cytoplasmic Skp1/Cul1/F-box protein complex
A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
nuclear cullin complex
nuclear SCF complex
nuclear Skp1/Cul1/F-box protein complex
Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.
laminin-111 binding
A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage.
FA complex
FA core complex
FA nuclear complex
Fanconi anaemia complex
A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains.
laminin-411 complex
A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains.
laminin-421 complex
A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains.
laminin-511 complex
A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains.
laminin-521 complex
A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains.
laminin-213 complex
Catalysis of the reaction: ADP + H2O = AMP + phosphate + H+.
adenosine diphosphatase activity
adenosine-diphosphatase activity
ADP diphosphatase activity
ADPase
ADPase activity
ATP diphosphohydrolase activity
ATP-diphosphatase activity
An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose.
scaffoldin complex
The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring as part of the process of jasmonic acid and ethylene-dependent systemic resistance.
ethylene anabolism during jasmonic acid and ethylene-dependent systemic resistance
ethylene biosynthetic process during jasmonic acid and ethylene-dependent systemic resistance
ethylene formation during jasmonic acid and ethylene-dependent systemic resistance
ethylene synthesis during jasmonic acid and ethylene-dependent systemic resistance
Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction.
CTPase activity, coupled
cytidine triphosphatase activity
single-stranded DNA-dependent CTPase activity
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria.
regulation of PHA
regulation of poly(3-hydroxyalkanoate) anabolism
regulation of poly(3-hydroxyalkanoate) biosynthesis
regulation of poly(3-hydroxyalkanoate) formation
regulation of poly(3-hydroxyalkanoate) synthesis
Binding to a poly(3-hydroxyalkanoate), a polyester of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria.
PHA binding
A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme.
regulator of the (H+)-ATPase of the vacuolar and endosomal membranes
Any process that stops, prevents, or reduces the rate of mast cell degranulation.
down regulation of mast cell degranulation
down-regulation of mast cell degranulation
downregulation of mast cell degranulation
inhibition of mast cell degranulation
negative regulation of mast cell granule exocytosis
Any process that stops, prevents, or reduces the rate of eosinophil degranulation.
down regulation of eosinophil degranulation
down-regulation of eosinophil degranulation
downregulation of eosinophil degranulation
inhibition of eosinophil degranulation
negative regulation of eosinophil granule exocytosis
Any process that activates or increases the frequency, rate or extent of eosinophil degranulation.
activation of eosinophil degranulation
positive regulation of eosinophil granule exocytosis
stimulation of eosinophil degranulation
up regulation of eosinophil degranulation
up-regulation of eosinophil degranulation
upregulation of eosinophil degranulation
Any process that stops, prevents, or reduces the rate of neutrophil degranulation.
down regulation of neutrophil degranulation
down-regulation of neutrophil degranulation
downregulation of neutrophil degranulation
inhibition of neutrophil degranulation
negative regulation of neutrophil granule exocytosis
Any process that activates or increases the frequency, rate or extent of neutrophil degranulation.
activation of neutrophil degranulation
positive regulation of neutrophil granule exocytosis
stimulation of neutrophil degranulation
up regulation of neutrophil degranulation
up-regulation of neutrophil degranulation
upregulation of neutrophil degranulation
Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation.
down regulation of cytotoxic T cell degranulation
down-regulation of cytotoxic T cell degranulation
downregulation of cytotoxic T cell degranulation
inhibition of cytotoxic T cell degranulation
negative regulation of cytotoxic T cell granule exocytosis
negative regulation of cytotoxic T lymphocyte degranulation
negative regulation of cytotoxic T lymphocyte granule exocytosis
negative regulation of cytotoxic T-cell degranulation
negative regulation of cytotoxic T-cell granule exocytosis
negative regulation of cytotoxic T-lymphocyte degranulation
negative regulation of cytotoxic T-lymphocyte granule exocytosis
Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation.
activation of cytotoxic T cell degranulation
positive regulation of cytotoxic T cell granule exocytosis
positive regulation of cytotoxic T lymphocyte degranulation
positive regulation of cytotoxic T lymphocyte granule exocytosis
positive regulation of cytotoxic T-cell degranulation
positive regulation of cytotoxic T-cell granule exocytosis
positive regulation of cytotoxic T-lymphocyte degranulation
positive regulation of cytotoxic T-lymphocyte granule exocytosis
stimulation of cytotoxic T cell degranulation
up regulation of cytotoxic T cell degranulation
up-regulation of cytotoxic T cell degranulation
upregulation of cytotoxic T cell degranulation
Any process that stops, prevents, or reduces the rate of natural killer cell degranulation.
down regulation of natural killer cell degranulation
down-regulation of natural killer cell degranulation
downregulation of natural killer cell degranulation
inhibition of natural killer cell degranulation
negative regulation of natural killer cell granule exocytosis
negative regulation of NK cell degranulation
negative regulation of NK cell granule exocytosis
Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation.
activation of natural killer cell degranulation
positive regulation of natural killer cell granule exocytosis
positive regulation of NK cell degranulation
positive regulation of NK cell granule exocytosis
stimulation of natural killer cell degranulation
up regulation of natural killer cell degranulation
up-regulation of natural killer cell degranulation
upregulation of natural killer cell degranulation