NothingMuch/GO-Terms huggingface dataset:
The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD).
Notch S2 cleavage
Notch S3 cleavage
The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface.
Notch S1 cleavage
The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
long-chain fatty acyl CoA biosynthetic process
long-chain fatty-acyl-CoA anabolism
long-chain fatty-acyl-CoA biosynthesis
long-chain fatty-acyl-CoA formation
long-chain fatty-acyl-CoA synthesis
Any process that activates or increases the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of hypoxanthine riboside transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of hypoxanthine riboside transport
Any process that activates or increases the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of 6-hydroxypurine transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of 6-hydroxypurine transport
The process in which acetyl-CoA is transported across a membrane. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
acetyl-CoA membrane transport
The process in which nicotinamide mononucleotide is transported across a membrane. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP.
nicotinamide mononucleotide membrane transport
A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2).
TLR1-TLR2 protein complex
TLR1:TLR2 complex
TLR2:TLR1 heterodimer
toll-like receptor TLR1:TLR2 heterodimeric complex
A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6).
TLR2-TLR6 protein complex
TLR2:TLR6 heterodimer
TLR6:TLR2 complex
toll-like receptor TLR6:TLR2 heterodimeric complex
A homeostatic process involved in the maintenance of a steady state level of triglyceride within a cell.
cellular triglyceride homeostasis
Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.
negative regulation of peroxisome proliferator activated receptor signalling pathway
negative regulation of peroxisome proliferator-activated receptor signaling pathway
negative regulation of PPAR signaling pathway
Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.
positive regulation of peroxisome proliferator activated receptor signalling pathway
positive regulation of peroxisome proliferator-activated receptor signaling pathway
positive regulation of PPAR signaling pathway
The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex, in which the complex is formed through interaction of the protein(s) with a interferon-stimulated response element (ISRE) in the DNA.
protein-DNA interferon-stimulated response element complex assembly
A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body.
HLB
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of 5-methyluracil transport
Any process that activates or increases the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of 5-methyluracil transport
Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation.
SECIS binding
An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
pre-BCR
Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.
proenzyme binding
The process in which carbon dioxide (CO2) is transported across a membrane.
carbon dioxide membrane transport
Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.
very-long-chain-3-hydroxyacyl-CoA dehydrogenase activity
The process in which a sterol is transported across a membrane. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
sterol membrane transport
Any process that activates or increases the frequency, rate or extent of the Roundabout signaling pathway.
positive regulation of Roundabout signalling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9.
negative regulation of CXCL9 production
negative regulation of MIG production
Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9.
positive regulation of CXCL9 production
positive regulation of MIG production
Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell.
helper T cell enhancement of T cell mediated immunity
provision of T cell help to T cell
Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell.
helper T cell enhancement of B cell mediated immunity
provision of T cell help to B cell
Catalysis of the reaction: histone H3-tyrosine (position 41) + ATP = histone H3-phosphotyrosine (position 41) + ADP. This reaction is the addition of a phosphate group to the tyrosine residue at position 41 of histone H3.
histone H3-Y41 kinase activity
histone kinase activity (H3-Y41 specific)
histone tyrosine kinase activity (H3-Y41 specific)
histone-tyrosine kinase activity (H3-Y41 specific)
Catalysis of the reaction: histone H3-threonine (position 11) + ATP = histone H3-phosphothreonine (position 11) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 11 of histone H3.
histone H3-T11 kinase activity
histone kinase activity (H3-T11 specific)
histone threonine kinase activity (H3-T11 specific)
histone-threonine kinase activity (H3-T11 specific)
Catalysis of the reaction: histone H3-threonine (position 6) + ATP = histone H3-phosphothreonine (position 6) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 6 of histone H3.
histone H3-T6 kinase activity
histone kinase activity (H3-T6 specific)
histone threonine kinase activity (H3-T6 specific)
histone-threonine kinase activity (H3-T6 specific)
Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type.
autocrine signalling
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore.
down regulation of gluconate transport
down-regulation of gluconate transport
downregulation of gluconate transport
inhibition of gluconate transport
negative regulation of gluconate membrane transport
negative regulation of gluconate transport
Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore.
activation of gluconate transport
induction of gluconate transport
positive regulation of gluconate membrane transport
positive regulation of gluconate transport
stimulation of gluconate transport
up regulation of gluconate transport
up-regulation of gluconate transport
upregulation of gluconate transport
The process in which triose phosphate (glyceraldehyde 3-phosphate) is transported across a membrane. Glyceraldehyde 3-phosphate is any organic three carbon compound phosphate ester.
triose phosphate membrane transport
Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
3\',5\'-cyclic di-GMP binding
c-di-GMP binding
cyclic dinucleotide di-GMP binding
Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate.
halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)
halimadienyl diphosphate synthase activity
The chemical reactions and pathways resulting in the formation of tuberculosinol (halima-5,6,dien-15-ol), a secondary metabolite in Mycobacteria.
halima-5,6,dien-15-ol biosynthesis
halima-5,6,dien-15-ol biosynthetic process
tuberculosinol biosynthesis
Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins.
desacetylmycothiol synthase
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
MshC ligase
Catalysis of the reaction: 1D-myo-inositol-2-(L-cysteinylamido)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coA + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol.
acetyl-CoA:Cys-GlcN-Ins acetyltransferase
The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region.
extrinsic to stromal leaflet of plastid thylakoid membrane
extrinsic to stromal side of plastid thylakoid membrane
peripheral to stromal side of plastid thylakoid membrane
The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region.
extrinsic to stromal leaflet of plastid inner membrane
extrinsic to stromal side of plastid inner membrane
peripheral to stromal side of plastid inner membrane
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
cellular response to interferon alfa-n1
cellular response to interferon alfa-n3
cellular response to leukocyte interferon
cellular response to lymphoblast interferon
cellular response to lymphoblastoid interferon
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
cellular response to beta-1 interferon
cellular response to fiblaferon
cellular response to fibroblast interferon
The series of molecular signals initiated by luteinizing hormone binding to a receptor, where the activated receptor signals via downstream effectors that contribute to progression of the ovarian follicle over time, from its formation to the mature structure.
luteinizing hormone signalling pathway involved in ovarian follicle development
Combining with the choriogonadotropin hormone to initiate a change in cell activity.
CG receptor activity
chorio-gonadotrophin receptor activity
chorionic gonadotropin hormone receptor
Binding to a double-stranded DNA region containing an A/A mispair.
A/A mispair binding
Binding to a double-stranded DNA region containing an A/G mispair.
A/G mispair binding
G/A mispair binding
guanine-adenine mispair binding
Binding to a double-stranded DNA region containing a C/C mispair.
C/C mispair binding
Binding to a double-stranded DNA region containing a T/T mispair.
T/T mispair binding
Binding to a double-stranded DNA region containing a C/T mispair.
C/T mispair binding
T/C mispair binding
thymine/cytosine mispair binding
Binding to a double-stranded DNA region containing a G/G mispair.
G/G mispair binding
Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide.
LPS-1,5-galactosyltransferase activity
UDP-D-galactose:(glucosyl)lipopolysaccharide-1,5-D-galactosyltransferase
Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.
cAMP-responsive element binding
CRE binding
cyclic AMP response element binding
cyclic-AMP response element binding
cyclic-AMP-responsive element binding
The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine).
carnosine anabolism
carnosine biosynthesis
carnosine formation
carnosine synthesis
Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers.
MAD homology 2 domain binding
Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors.
MAD homology 1 domain binding
Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA.
1-ethyladenine demethylase activity
2-oxoglutarate-dependent DNA demethylase
5-formylcytosine dioxygenase activity
5-hydroxymethylcytosine dioxygenase activity
5fC dioxygenase
5hmC dioxygenase
N1-methyladenine demethylase activity
N3-methylcytosine demethylase activity
oxidative DNA demethylase activity
A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively.
Polycomb repressive deubiquitinase complex
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation.
protein K29-linked polyubiquitination
The removal of the ubiquitin group from a monoubiquitinated protein.
monoubiquitinated protein deubiquitinylation
monoubiquitinated protein deubiquitylation
A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein.
protein K29-linked deubiquitinylation
protein K29-linked deubiquitylation
A heterodimer of NF-kappa B p50 and p65 subunits.
NF-kappa B1/p65 complex
NF-kappa B1/RelA complex
NF-kappa p105/p65 complex
NF-kappa p105/RelA complex
NF-kappa p50/RelA complex
Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH.
3-hydroxypropanoate dehydrogenase (NADP+) activity
3-hydroxypropanoate:NADP+ oxidoreductase
3-hydroxypropionate:NADP+ oxidoreductase
Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+.
NADH diphosphatase activity
NADH pyrophosphohydrolase activity
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6).
negative regulation of CCL6 production
negative regulation of chemokine (C-C motif) ligand 6 secretion
Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6).
positive regulation of CCL6 production
positive regulation of chemokine (C-C motif) ligand 6 secretion
Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes.
ChoRE binding
Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
8-oxo-7,8-dihydro-2\'-deoxyguanosine 5\'-triphosphate pyrophosphohydrolase activity
8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity
8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity
8-oxo-dGTP pyrophosphohydrolase activity
8-oxo-dGTPase activity
Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a.
phedase activity
pheophoridase activity
PPD activity
Any process that modulates the size of a pronephric kidney.
regulation of pronephric kidney size
Any process that modulates the size of a metanephric kidney.
regulation of metanephric kidney size
Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
histone demethylase activity (H4-K20 specific)
histone demethylase activity (H4K20-specific)
histone H4-K20 demethylase activity
histone H4-methyl-lysine-20 demethylase activity
histone H4K20me demethylase activity
The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
primary granule membrane
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
primary granule lumen
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
secondary granule membrane
The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
secondary granule lumen
Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
BMP sequestration in the ECM
negative regulation of BMP signaling pathway by extracellular sequestering of BMP
negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP
negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein
Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins.
negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta
negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta
sequestering of TGFbeta large latency complex in extracellular matrix
sequestering of TGFbeta LLC in extracellular matrix
A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process.
G-protein coupled purinergic nucleotide receptor signaling pathway
G-protein coupled purinergic nucleotide receptor signalling pathway
P2Y receptor signaling pathway
Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol.
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase activity
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase activity
GlcNAc-Ins deacetylase activity
N-acetyl-1D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase activity
Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A).
i6A methylthiotransferase activity
Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A).
t6A methylthiotransferase activity