NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-glutamine (position 104) = S-adenosyl-L-homocysteine + (histone H2A)-N5-methyl-glutamine (position 104). Note that this corresponds to Q105 in yeast.
histone glutamine methylase activity
histone glutamine methyltransferase activity
histone glutamine N-methyltransferase activity
histone-glutamine methyltransferase activity
histone-glutamine N-methyltransferase activity
The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA).
pre-mRNA decay
unspliced RNA decay
A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD).
PDGF complex
PDGF-AA dimer
PDGF-AB dimer
PDGF-BB dimer
PDGF-CC dimer
PDGF-DD dimer
Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II.
RNA Pol II C-terminal domain phosphoserine binding
RNAP II C-terminal domain phosphoserine binding
A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes.
PDGF complex
PDGF receptor-ligand complex
PDGF-AA-receptor alpha complex
PDGF-AB-receptor alpha complex
PDGF-AB-receptor beta complex
PDGF-BB-receptor alpha complex
PDGF-BB-receptor alpha-beta complex
PDGF-BB-receptor beta complex
PDGF-CC-receptor alpha complex
PDGF-CC-receptor alpha-beta complex
PDGF-CC-receptor beta complex
PDGF-DD-receptor alpha-beta complex
PDGF-DD-receptor beta complex
receptor-ligand complex
The sequence of enzymatic reactions by which a 2,2,7-trimethylguanosine cap structure is added to the 5' end of an snRNA. The snRNA capping process includes the formation of 7-methyl-G caps found on all RNA polymerase II transcripts, followed by hypermethylation at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. Note that the pol III transcribed U6 snRNA is also TMG capped.
snRNA 2,2,7-trimethylguanosine (TMG) cap formation
snRNA 5\'-end processing
snRNA capping
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 5'-gamma-phosphate in an RNA molecule.
RNA 5\'-methyltransferase activity
A type of reproduction in which new individuals are produced from two individuals, with the fusion of two somatic cells.
mating
parasexual conjugation with cellular fusion
A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin.
RNA localisation to chromatin
A protein complex that is capable of efflux transmembrane transporter activity.
efflux pump
efflux transmembrane transporter complex
Binding to a cellulosome, an extracellular multi-enzyme complex containing several enzymes aligned on a non-catalytic scaffolding that functions to hydrolyze plant cell wall polysaccharides.
scaffoldin complex binding
A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis.
Bre1-Rad6 complex
A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes.
UBR1-RAD6 complex
A ubiquitin ligase complex consisting of RAD6 and UBR2 components. It may act in a quality control pathway for proteins synthesized on cytosolic ribosomes. The UBR2 component lacks sequence motifs required for N-end rule degradation.
RAD6-UBR2 complex
A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation.
RSP5-BUL1 complex
RSP5-BUL2 complex
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.
cellular response to insulin-like growth factor
A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.
ATG1 kinase complex
ATG1-ATG13 complex
ATG1/ULK1 signaling complex
Atg1p signalling complex
autophagy-initiation complex
ULK complex
ULK1 complex
ULK1 signaling complex
ULK1-ATG13-FIP200 complex
ULK1-ATG13-RB1CC1 complex
A protein complex involved in septin ring formation during mitosis. In Saccharomyces cerevisiae it consists of BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. At least 2 GIN4 molecules are involved.
Gin4-septin complex
A protein complex that cycles between the nucleus where it is part of the RNA polymerase II and the cytoplasmic mRNA processing body where it mediates the two major cytoplasmic mRNA decay pathways.
RNA polymerase II, RPB4-RPB7 subcomplex
A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.
ER-bound kinase/endoribonuclease (RNase), inositol-requiring enzyme-1
ERN1 complex
Ire1 complex dimer
Ire1 complex homodimer
Ire1 complex homooligomer
IRE1 dimer
A protein complex involved in the spindle checkpoint, preventing the activation of the anaphase-promoting complex until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. In budding yeast this complex consists of Mad2p and Cdc20p, and in mammalian cells it consists of MAD2 and CDC20.
CDC20-MAD2 complex
A laminin complex composed of alpha4, beta2 and gamma3 polypeptide chains.
laminin-423
A laminin complex composed of alpha5, beta2 and gamma2 polypeptide chains.
laminin-522
A laminin complex composed of alpha5, beta2 and gamma3 polypeptide chains.
laminin-523
A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me).
HOOD
A homodimeric protein complex composed of the E3 ubiquitin-protein ligase BRE1. Plays a role in regulating association of RNA polymerase II with active genes.
BRE1 E3 ubiquitin-protein ligase complex
BRE1 oligomer
A protein complex consisting of a SUMO protein bound to a SUMO activating enzyme complex. Activation by the E1 complex and linkage to the E2 enzyme UBE2I is required for the formation of covalent bonds between SUMO and its ultimate target proteins.
SUMO-SAE1/2 complex
The generation of L-methionine from methionine sulphoxide.
methionine salvage from methionine sulphoxide
A multifunctional supermolecular complex, containing several proteins with hemicellulase activity. Functions to hydrolyze hemicellulose.
xylanolytic complex
A protein complex capable of phosphorylating a large number of protein targets. Contributes to cell proliferation under glycose starvation conditions. In human, the complex is present as a dimer.
PKM2-SAICAR complex
PKM2-SAICAR protein kinase complex
A protein complex capable of pyruvate kinase activity. PKM2 only exists as homotetramer when bound to beta-d-fructofuranose 1,6-bisphosphate (CHEBI:28013).
PKM2 homotetramer
Catalysis of the reaction: butan-1-ol + NAD+ = butanal + H+ + NADH.
butanol dehydrogenase activity
A inward rectifier potassium channel complex. Homo- or heterotetramer composed of subunits of the eukaryotic Kir2 protein family. Plays a key role in maintaining the correct resting potential in eukaryotic cells.
Kir2.1 complex
The reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure.
os penis development
penile bone development
penis bone development
A protein complex capable of sequence-specific DNA binding RNA polymerase II transcription factor activity through binding to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3'). Found in a variety of viral and cellular promoters.
USF complex
USF1 homodimer
USF1-USF2 heterodimer
USF2 homodimer
Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin.
K48-specific deubiquitinase activity
K48-specific deubiquitinating activity
Lys48-specific deubiquitinase activity
Binding to a ubiquitin-specific protease.
deubiquitinase binding
deubiquitinating enzyme binding
A protein complex capable of ubiquitin-conjugating enzyme activity during ER-associated protein degradation (ERAD). In S. cerevisiae, UBC7 is the ubiquitin-conjugating enzyme (E2) and requires binding to the ER surface by CUE1.
CUE1-UBC7 ubiquitin-conjugating enzyme (E2)
Transmembrane complex that mediates resistance to copper and silver by cation efflux directly from the cell using the proton-motive force. Spans the inner membrane, periplasm, and outer membrane. Primarily activated under anaerobic conditions by CusR and CusS but also expressed under extreme copper stress, in aerobic growth.
copper efflux complex
copper efflux system
Cus cation efflux system
silver efflux complex
silver efflux system
Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA).
21S rRNA binding
mitochondrial LSU rRNA binding
A transmembrane, G protein-coupled signaling receptor complex recognized by calcitonin gene-related peptides (CGRP).
calcitonin gene-related polypeptide receptor complex
Calcitonin-gene-related peptide receptor complex
CGRP-R complex
Binding to calcitonin gene-related peptide (CGRP).
calcitonin-gene-related peptide binding
calcitonin-gene-related polypeptide binding
CGRP polypeptide binding
The series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers.
calcitonin-gene-related peptide receptor signaling pathway
calcitonin-gene-related polypeptide receptor signaling pathway
CGRP receptor signaling pathway
Binding to adrenomedullin (AM).
AM binding
The series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell.
AM receptor signaling pathway
A small pigmented organelle used in single-celled organisms to detect light.
eyespot
stigma
The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks.
replication-born DSB repair by SCE
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus.
cellular response to BDNF stimulus
The septation initiation signaling process by which the activity of the septation initiation network (SIN) is activated asymmetrically on the spindle pole bodies.
establishment of SIN asymmetry
A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints.
Rod-Zwilch-Zw10 complex
Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate.
protein-arginine kinase activity
A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom.
RyR
A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners.
peroxisomal import pore
peroxisomal protein import machinery
Pex14 complex
Pex17p-Pex14p docking complex
The process of forming the mature 3' end of a priRNA molecule.
primal small RNA 3\'-end processing
priRNA 3\' end processing
The process of forming the mature 3' end of a siRNA molecule.
siRNA 3\' end processing
small interfering RNA 3\'-end processing
A DNA-binding transcription factor complex consisting of CSL and mastermind proteins in complex with the cleaved, intracellular domain of Notch. It is required for both repression and activation of Notch target genes.
CSL-NotchIC-MASTERMIND complex
An electron-dense plaque at the lower end of a stereocilia tip link that provides the anchor in the stereocilia membrane at the tip of the stereocilium from which the tip link rises.
LTLD
An electron-dense plaque at the upper end of a stereocilia tip link that provides the anchor in the stereocilia membrane on the side of the stereocilium where the tip link ends.
UTLD
Binding to an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.
EJC binding
Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next.
M1-linked ubiquitin chain binding
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution.
cellular stress response to acidity
A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein.
Park2-FBXW7-Cul1 complex
Parkin-FBXW7-Cul1 protein complex
Parkin-HSel-10-Cullin-1 complex
Parkin/Cul1/F-box protein complex
PRKN-FBXW7-Cul1 complex
A protein complex involved in the disassembly and subsequent reassembly of nucleosomes. It associates with the coding region of transcriptionally active genes where it interacts with the RNA polymerase II and affects its processivity during co-transcriptional RNA processing and maturation. It exists as a functionally independent part of the NuA4 complex.
eaf5/7/3 complex
A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.
cardiac muscle L-type voltage-gated calcium channel complex
skeletal muscle L-type voltage-gated calcium channel complex
A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function.
phosphatase and tensin homolog
phosphatase and tensin homolog deleted on chromosome ten homodimer
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer
The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.
mitochondrion-endoplasmic reticulum attachment
mitochondrion-endoplasmic reticulum tethering
mitochondrion-ER attachment
mitochondrion-ER membrane tethering
mitochondrion-ER tethering
Binding to lipooligosaccharide. Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-negative bacteria.
endotoxin binding
LOS binding
A protein complex that is anchored at the cortical face of the plasma membrane, and contains proteins involved in regulating cell cycle progression. In Schizosaccharomyces pombe, lateral cortical nodes are several megadaltons in size, and contain Slf1, which anchors the complex at the membrane, and the methyltransferase Skb1 in stoichiometric quantities, and may contain other proteins.
Skb1-containing cortical node
Catalysis of the reaction: a (2R)-2-hydroxycarboxylate + a quinone = a 2-oxocarboxylate + a quinol.
(R)-2-hydroxy acid dehydrogenase activity
(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity
(R)-2-hydroxyacid:quinone oxidoreductase activity
D-lactate dehydrogenase (quinone) activity
D-lactate dehydrogenase activity
D-lactate:quinone oxidoreductase activity
The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.
protein auto-sumoylation
protein self-sumoylation
Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation.
RDC complex
rhi-del-cuff complex
Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane.
CTS binding
A synaptic vesicle belonging to the pool of vesicles that are the first to be released as a result of chemical or electrical stimulation e.g. by an action potential, have the highest presynaptic membrane fusion probability and correspond to about 1% of the total number of synaptic vesicles at a resting terminal bouton.
readily releasable pool of synaptic vesicles
RRP
A synaptic vesicle belonging to the pool that repopulate vacancies within the readily releasable pool (RRP) of synaptic vesicles, and require more significant stimuli than the RRP in order to release neurotransmitter; about 10-15% of the total number of synaptic vesicles at a resting terminal bouton are in this state.
recycling pool of synaptic vesicles
A synaptic vesicle belonging to the pool that remain unreleased even after prolonged stimulation causes a saturating degree of vesicular turnover. 50-80% of the total number of synaptic vesicles at a resting terminal bouton are in this pool.
reserve pool of synaptic vesicles
resting pool of synaptic vesicles
Protein complex formed by an RNA binding protein Red1, an RNA helicase Mtl1, Red5, Rmn1, Iss10/Pir1, and Ars2/Pir2. This complex is required for the recruitment of the nuclear exosome to Mmi1 nuclear focus. It is likely related to the human CBCN complex. This complex is also known as RNA silencing (NURS) complex.
Mtl1-Red1 core complex
NURS complex
PAXT complex
The intramolecular conversion of uridine to pseudouridine in an mRNA molecule.
mRNA pseudouridylation
Catalysis of the reaction: UDP-glucuronate + inositol phosphorylceramide (IPC) = UDP + GlcA-IPC.
inositol phosphorylceramide glucuronosyltransferase activity
The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the presence of oxygen.
aerobic lactic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the absence of oxygen.
anaerobic lactic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of a fatty acid in the absence of oxygen. A fatty acid is any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
anaerobic fatty acid degradation
The chemical reactions and pathways resulting in the breakdown of lignin in the absence of oxygen. Lignin is a class of polymers of phenylpropanoid units.
anaerobic lignin degradation
The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, in absence of oxygen.
anaerobic cellulose degradation
The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, in the absence of oxygen.
anaerobic pectin degradation
A large proton-transporting two-sector ATPase protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane and is found in Archaea.
A-type ATPase protein complex
archaeal A-type ATPase protein complex
The chemical reactions and pathways resulting in the formation of methane from methanol and hydrogen.
methane biosynthesis from methanol and hydrogen
methanogenesis from methanol and hydrogen
Protein complex required for the asymmetric division of neuroblasts in Drosophila. Coordinates asymmetric localization of cell fate determinants with orientation of the mitotic spindle resulting in different daughter cells upon division. Localizes at the apical cortex of the neuroblast: Raps maintains, but does not initiate, Insc apically, while Insc segregates Raps asymmetrically. Complex appears to be conserved in mammals (composed of INSC and GPSM1 or GPSM2).
partner of inscuteable-inscuteable complex
Rapsynoid-Inscuteable complex
A protein complex that causes translational repression in Drosophila. Prevents assembly of ribosomes at the mRNA by interfacing with a sequence-specific RNA-binding protein leading to recruitment of the CCR4 complex and consequently, reduction of the mRNA's poly(A) tail length. The complex is also required for dorso-ventral pattern formation in the embryo.
eukaryotic translation initiation factor 4E-cup complex
Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA.
exon junction subcomplex MAGOH-Y14
mago-y14 complex
MGN-RBM8A complex