NothingMuch/GO-Terms huggingface dataset:
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
pancreatic alpha cell differentiation
The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.
pancreatic delta cell differentiation
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.
pancreatic polypeptide-producing cell differentiation
The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.
heart cone development
The process in which the anatomical structures of the heart rudiment are generated and organized.
heart cone morphogenesis
The developmental process pertaining to the initial formation of the heart rudiment.
heart cone formation
The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
pancreatic B cell development
pancreatic beta cell development
The process in which an amino acid is transported across a membrane.
amino acid membrane transport
A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
metanephric mesenchyme to epithelial transition
The directed, self-propelled movement of a cilium.
ciliary motility
cilium beating
flagellar motility
flagellar movement
flagellum movement
microtubule-based flagellum movement
The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
cilium movement involved in fluid flow
epithelial cilium beating
Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
regulation of flagellar movement
regulation of flagellum movement
regulation of microtubule-based flagellum movement
Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
positive regulation of flagellar movement
positive regulation of flagellum movement
positive regulation of microtubule-based flagellum movement
Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
negative regulation of flagellum movement
negative regulation of microtubule-based flagellum movement
Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium.
regulation of flagellum beat frequency
regulation of microtubule-based flagellum beat frequency
The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline.
norepinephrine secreting neuron differentiation
The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron.
norepinephrine secreting neuron fate commitment
The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point.
dendrite retrograde extension
The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure.
elongation of an axis
The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte.
growth plate cartilage chondrocyte polarization
The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another.
growth plate cartilage chondrocyte hypertrophy
A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
molecular function
Binding to a nucleic acid.
base pairing
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
microtubule/chromatin interaction
plasmid binding
structure specific DNA binding
structure-specific DNA binding
Unwinding of a DNA helix, driven by ATP hydrolysis.
ATP-dependent DNA helicase activity
Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
lamin/chromatin binding
microtubule/chromatin interaction
nuclear membrane vesicle binding to chromatin
Binding to damaged DNA.
DNA repair enzyme
DNA repair protein
Binding to double-stranded DNA.
dsDNA binding
Binding to single-stranded DNA.
ssDNA binding
A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
bacterial-type DNA binding transcription factor activity
bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity
bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
DNA binding transcription factor activity
gene-specific transcription factor activity
metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
metal ion regulated sequence-specific DNA binding transcription factor activity
nucleic acid binding transcription factor activity
sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
sequence-specific DNA binding transcription factor activity
transcription factor activity
transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding
transcription factor activity, metal ion regulated sequence-specific DNA binding
Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
steroid hormone receptor activity
A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
nuclear receptor coreceptor activity
RNA polymerase II transcriptional cofactor activity
transcription cofactor activity
transcription coreceptor activity
transcriptional co-regulator
A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
RNA polymerase II transcription co-activator activity
RNA polymerase II transcription coactivator activity
RNA polymerase II transcription mediator activity
transcription co-activator activity
A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
RNA polymerase II transcription co-repressor activity
RNA polymerase II transcription corepressor activity
transcription co-repressor activity
Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) using an internal RNA template that encodes the telomeric repeat sequence.
telomerase RNA reverse transcriptase activity
telomerase, catalyst
Binding to an RNA molecule or a portion thereof.
base pairing with RNA
poly(A) RNA binding
poly(A)-RNA binding
poly-A RNA binding
Unwinding of an RNA helix, driven by ATP hydrolysis.
ATP-dependent RNA helicase activity
Binding to double-stranded RNA.
dsRNA binding
Binding to single-stranded RNA.
ssRNA binding
Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
base pairing with mRNA
Binding to a 3' untranslated region of an mRNA molecule.
mRNA 3\' UTR binding
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
cis-trans proline isomerase activity
cyclophilin activity
cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
FK506-sensitive peptidyl-prolyl cis-trans isomerase
immunophilin
juglone-sensitive cis-trans proline isomerase activity
juglone-sensitive peptidyl-prolyl cis-trans isomerase activity
parvulin
peptide bond isomerase activity
peptidyl-prolyl isomerase B reaction
peptidylproline cis-trans-isomerase activity
peptidylprolyl cis-trans isomerase activity
peptidylprolyl isomerase activity
PPIase activity
rotamase activity
Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
motor activity
A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.
ATP-dependent microtubule motor activity
axonemal motor activity
dynein
dynein ATPase activity
kinesin
kinesin motor activity
kinetochore motor activity
Binding to monomeric or multimeric forms of actin, including actin filaments.
membrane associated actin binding
Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein complex allows the antigen to be displayed to a T cell or NK cell.
antibody activity
B cell receptor activity
major histocompatibility complex activity
major histocompatibility complex antigen display activity
MHC activity
opsonin activity
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
enzyme activity
Catalysis of the reaction: UDP-glucose + (n) = UDP + (n+1).
(1,3)-beta-glucan (callose) synthase activity
1,3-beta-D-glucan synthetase activity
1,3-beta-D-glucan-UDP glucosyltransferase activity
1,3-beta-glucan synthase activity
1,3-beta-glucan-uridine diphosphoglucosyltransferase activity
beta-1,3-glucan synthase activity
beta-1,3-glucan synthetase activity
callose synthase activity
callose synthetase activity
GS-II
paramylon synthetase
UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity
UDP-glucose-1,3-beta-glucan glucosyltransferase activity
UDP-glucose-beta-glucan glucosyltransferase activity
UDP-glucose:(1,3)beta-glucan synthase activity
UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity
UDPglucose-1,3-beta-D-glucan glucosyltransferase activity
UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity
uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity
Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+.
11beta-hydroxy steroid dehydrogenase
11beta-hydroxysteroid dehydrogenase
beta-hydroxysteroid dehydrogenase
corticosteroid 11-reductase
corticosteroid 11beta-dehydrogenase
Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H+. Also acts on on 3-beta-hydroxypregn-5-en-20-one to form progesterone.
3-beta-hydroxy-5-ene steroid dehydrogenase activity
3-beta-hydroxy-D5-steroid dehydrogenase activity
3beta-HSDH
3beta-hydroxy steroid dehydrogenase/isomerase activity
3beta-hydroxy-5-ene steroid dehydrogenase activity
3beta-hydroxy-5-ene-steroid dehydrogenase activity
3beta-hydroxy-5-ene-steroid oxidoreductase activity
3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity
3beta-hydroxy-delta5-C27-steroid oxidoreductase
3beta-hydroxy-delta5-steroid dehydrogenase activity
3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity
5-ene-3-beta-hydroxysteroid dehydrogenase activity
delta5-3beta-hydroxysteroid dehydrogenase activity
progesterone reductase activity
steroid-delta5-3beta-ol dehydrogenase activity
Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+.
3-oxoacyl-thioester reductase activity
beta-hydroxyacyl dehydrogenase activity
beta-hydroxyacyl-coenzyme A synthetase activity
beta-hydroxyacylcoenzyme A dehydrogenase activity
beta-hydroxybutyrylcoenzyme A dehydrogenase activity
beta-keto-reductase activity
beta-ketoacyl-CoA reductase
L-3-hydroxyacyl CoA dehydrogenase activity
L-3-hydroxyacyl coenzyme A dehydrogenase activity
Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor.
3-keto-delta4-steroid-5alpha-reductase activity
3-oxo-5alpha-steroid 4-dehydrogenase activity
3-oxo-5alpha-steroid delta4-dehydrogenase activity
3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity
3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity
3-oxosteroid delta4-dehydrogenase
4-ene-3-ketosteroid-5alpha-oxidoreductase activity
5alpha-reductase
delta4-3-keto steroid 5alpha-reductase activity
delta4-3-ketosteroid5alpha-oxidoreductase activity
delta4-3-oxo steroid reductase activity
delta4-3-oxosteroid-5alpha-reductase
delta4-5alpha-dehydrogenase activity
steroid 5 alpha reductase
steroid 5-alpha-reductase activity
steroid 5alpha-reductase
steroid delta4-5alpha-reductase activity
testosterone 5alpha-reductase
Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein.
C-terminal protein carboxyl methyltransferase activity
Catalysis of the reaction: a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4+.
D-amino-acid:oxygen oxidoreductase (deaminating)
L-amino acid:O2 oxidoreductase activity
new yellow enzyme
Catalysis of the reaction: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H+ + S-adenosyl-L-homocysteine.
cytosine 5-methyltransferase activity
cytosine DNA methylase activity
cytosine DNA methyltransferase activity
cytosine-specific DNA methyltransferase activity
deoxyribonucleic (cytosine-5-)-methyltransferase activity
deoxyribonucleic acid (cytosine-5-)-methyltransferase activity
deoxyribonucleic methylase activity
DNA 5-cytosine methylase activity
DNA cytosine C(5) methylase activity
DNA cytosine C5 methylase activity
DNA cytosine methylase activity
DNA-cytosine 5-methylase activity
DNA-cytosine methyltransferase activity
methylphosphotriester-DNA methyltransferase activity
modification methylase activity
restriction-modification system activity
S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity
site-specific DNA-methyltransferase (cytosine-specific) activity
type II DNA methylase activity
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
C ribonucleic acid formation factors
C RNA formation factors
deoxyribonucleic acid-dependent ribonucleic acid polymerase activity
DNA-dependent ribonucleate nucleotidyltransferase activity
DNA-dependent RNA nucleotidyltransferase activity
DNA-dependent RNA polymerase activity
DNA-directed RNA polymerase activity
DNA-directed RNA polymerase I activity
DNA-directed RNA polymerase II activity
DNA-directed RNA polymerase III activity
nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity
RNA nucleotidyltransferase (DNA-directed) activity
RNA polymerase I activity
RNA polymerase II activity
RNA polymerase III activity
transcriptase
Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.
3-methyladenine DNA glycosylase II
AlkA
alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
alkylbase DNA glycosidase activity
deoxyribonucleate 3-methyladenine glycosidase II
DNA glycosidase II activity
DNA-3-methyladenine glycosidase II activity
DNA-3-methyladenine glycosylase II
Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
abasic deoxyendoribonuclease activity
AP deoxyendoribonuclease activity
apurinic deoxyendoribonuclease activity
apurinic/apyrimidinic endodeoxyribonuclease activity
apyrimidinic deoxyendoribonuclease activity
deoxyribonuclease (apurinic or apyrimidinic) activity
endonuclease VIII activity
UV endonuclease
Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
deoxyribonucleate topoisomerase
deoxyribonucleic topoisomerase activity
DNA topoisomerase (ATP-hydrolysing)
DNA topoisomerase II
DNA topoisomerase II activity
DNA topoisomerase IV activity
DNA topoisomerase type II activity
topoisomerase
topoisomerase II
type II DNA topoisomerase activity
Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+.
glutamine amidotransferase activity
GMP synthase (glutamine-hydrolysing)
GMP synthetase (glutamine-hydrolysing)
GMP synthetase (glutamine-hydrolyzing) activity
guanosine 5\'-monophosphate synthetase activity
guanosine monophosphate synthetase (glutamine-hydrolyzing)
guanylate synthetase (glutamine-hydrolyzing)
xanthosine 5\'-phosphate amidotransferase activity
xanthosine-5\'-phosphate:L-glutamine amido-ligase (AMP-forming)
Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
ARF small monomeric GTPase activity
dynamin GTPase activity
GTPase activity, coupled
heterotrimeric G-protein GTPase activity
heterotrimeric G-protein GTPase, alpha-subunit
heterotrimeric G-protein GTPase, beta-subunit
heterotrimeric G-protein GTPase, gamma-subunit
hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
protein-synthesizing GTPase activity
protein-synthesizing GTPase activity, elongation
protein-synthesizing GTPase activity, initiation
protein-synthesizing GTPase activity, termination
Rab small monomeric GTPase activity
Ran small monomeric GTPase activity
Ras small monomeric GTPase activity
RHEB small monomeric GTPase activity
Rho small monomeric GTPase activity
Sar small monomeric GTPase activity
signal-recognition-particle GTPase activity
small monomeric GTPase activity
tubulin GTPase activity
Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
beta-NADH dehydrogenase dinucleotide activity
cytochrome c reductase activity
diaphorase activity
dihydrocodehydrogenase I dehydrogenase activity
dihydronicotinamide adenine dinucleotide dehydrogenase activity
diphosphopyridine diaphorase activity
diphosphopyrinase activity
DPNH diaphorase activity
NADH diaphorase activity
NADH hydrogenase activity
NADH oxidoreductase activity
NADH-menadione oxidoreductase activity
NADH2 dehydrogenase activity
NADH:(acceptor) oxidoreductase activity
NADH:acceptor oxidoreductase activity
NADH:cytochrome c oxidoreductase activity
reduced diphosphopyridine nucleotide diaphorase activity
type 1 dehydrogenase activity
type I dehydrogenase activity
Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol.
azoreductase activity
dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity
diaphorase activity
DT-diaphorase activity
flavoprotein NAD(P)H-quinone reductase activity
menadione oxidoreductase activity
menadione reductase activity
NAD(P)H dehydrogenase activity
NAD(P)H menadione reductase activity
NAD(P)H(2) dehydrogenase (quinone) activity
NAD(P)H-quinone dehydrogenase activity
NAD(P)H-quinone oxidoreductase activity
NAD(P)H2 dehydrogenase (quinone)
NAD(P)H: menadione oxidoreductase activity
NAD(P)H:(quinone-acceptor)oxidoreductase activity
NAD(P)H:quinone oxidoreductase activity
NADH-menadione reductase activity
naphthoquinone reductase activity
NQO1
p-benzoquinone reductase activity
phylloquinone reductase activity
QR1
quinone reductase activity
reduced NAD(P)H dehydrogenase activity
reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity
viologen accepting pyridine nucleotide oxidoreductase activity
vitamin K reductase activity
vitamin-K reductase activity