NothingMuch/GO-Terms huggingface dataset:
The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
EGF receptor signaling pathway
EGF receptor signalling pathway
EGFR signaling pathway
epidermal growth factor receptor signalling pathway
ERBB1 signaling pathway
receptor tyrosine-protein kinase erbB-1 signaling pathway
Any process that modulates the frequency, rate or extent of EGF-activated receptor activity.
regulation of EGF receptor activity
regulation of EGFR activity
regulation of epidermal growth factor receptor activity
The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
transmembrane receptor protein serine/threonine kinase signaling pathway
transmembrane receptor protein serine/threonine kinase signalling pathway
The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
TGF-beta receptor signaling pathway
TGF-beta receptor signalling pathway
TGFbeta receptor signaling pathway
TGFbeta receptor signalling pathway
transforming growth factor beta receptor signalling pathway
The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
dimeric G-protein coupled receptor signaling pathway
dimeric G-protein coupled receptor signalling pathway
G protein coupled receptor protein signaling pathway
G protein coupled receptor protein signalling pathway
G-protein coupled receptor protein signal transduction
G-protein coupled receptor protein signaling pathway
G-protein coupled receptor signaling pathway via GPCR dimer
G-protein coupled receptor signalling pathway
G-protein-coupled receptor protein signalling pathway
GPCR signaling pathway
GPCR signalling pathway
A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
G protein signaling, coupled to cyclic nucleotide second messenger
G protein signalling, coupled to cyclic nucleotide second messenger
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
G-protein signaling, coupled to cyclic nucleotide second messenger
G-protein signalling, coupled to cyclic nucleotide second messenger
GPCR signaling pathway via cyclic nucleotide second messenger
A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).
adenylate cyclase-modulating GPCR signaling pathway
G protein signaling, coupled to cAMP nucleotide second messenger
G protein signaling, coupled to cyclic AMP nucleotide second messenger
G protein signalling, coupled to cAMP nucleotide second messenger
G protein signalling, coupled to cyclic AMP nucleotide second messenger
G-protein signaling, coupled to cAMP nucleotide second messenger
G-protein signaling, coupled to cyclic AMP nucleotide second messenger
G-protein signalling, coupled to cAMP nucleotide second messenger
G-protein signalling, coupled to cyclic AMP nucleotide second messenger
GPCR signaling pathway via cAMP second messenger
GPCR signaling pathway via modulation of adenylate cyclase activity
A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling.
activation of adenylate cyclase activity by G-protein signaling pathway
activation of adenylate cyclase activity involved in G-protein signaling
adenylate cyclase-activating GPCR signaling pathway
G protein signaling, adenylate cyclase activating pathway
G protein signaling, adenylyl cyclase activating pathway
G protein signalling, adenylate cyclase activating pathway
G protein signalling, adenylyl cyclase activating pathway
G-protein signaling, adenylate cyclase activating pathway
G-protein signaling, adenylyl cyclase activating pathway
G-protein signalling, adenylate cyclase activating pathway
G-protein signalling, adenylyl cyclase activating pathway
GPCR signaling pathway via activation of adenylate cyclase
GPCR signaling pathway via activation of adenylate cyclase activity
positive regulation of adenylate cyclase activity by G-protein signaling pathway
positive regulation of adenylate cyclase activity by G-protein signalling pathway
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).
adenylate cyclase-inhibiting GPCR signaling pathway
G protein signaling, adenylate cyclase inhibiting pathway
G protein signaling, adenylyl cyclase inhibiting pathway
G protein signalling, adenylate cyclase inhibiting pathway
G protein signalling, adenylyl cyclase inhibiting pathway
G-protein signaling, adenylate cyclase inhibiting pathway
G-protein signaling, adenylyl cyclase inhibiting pathway
G-protein signalling, adenylate cyclase inhibiting pathway
G-protein signalling, adenylyl cyclase inhibiting pathway
GPCR signaling pathway via inhibition of adenylate cyclase activity
inhibition of adenylate cyclase activity by G-protein signaling pathway
An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process.
dopamine receptor, adenylate cyclase inhibiting pathway
dopamine receptor, adenylyl cyclase inhibiting pathway
inhibition of adenylate cyclase activity by dopamine receptor signaling pathway
inhibition of adenylate cyclase activity by dopamine receptor signalling pathway
A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors.
activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
G protein signaling, coupled to IP3 second messenger (phospholipase C activating)
G protein signalling, coupled to IP3 second messenger (phospholipase C activating)
G-protein coupled receptor signaling pathway coupled to IP3 second messenger
G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)
phospholipase C-activating G-protein coupled receptor signaling pathway
PLC-activating GPCR signaling pathway
protein kinase C-activating G protein-coupled receptor signaling pathway
Any process that increases the concentration of calcium ions in the cytosol.
cytoplasmic calcium ion concentration elevation
cytosolic calcium ion concentration elevation
elevation of calcium ion concentration in cytoplasm
elevation of calcium ion concentration in cytosol
elevation of cytoplasmic calcium ion concentration
elevation of cytosolic calcium ion concentration
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
serotonin receptor signalling pathway
A G protein-coupled receptor signaling pathway initiated by octopamine or tyramine binding to their receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription, and ending with the regulation of a downstream cellular process. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters.
octopamine or tyramine signalling pathway
octopamine/tyramine signaling pathway
A G protein-coupled receptor signaling pathway initiated by a dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
dopamine receptor signalling pathway
A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription.
acetylcholine receptor signalling, muscarinic pathway
G-protein coupled acetylcholine receptor signaling pathway
muscarinic acetylcholine receptor signaling pathway
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell.
4-aminobutanoate signaling pathway
4-aminobutanoate signalling pathway
4-aminobutyrate signaling pathway
4-aminobutyrate signalling pathway
GABA signaling pathway
GABA signalling pathway
gamma-aminobutyric acid signalling pathway
The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
glutamate signaling pathway
glutamate signalling pathway
A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
G-protein coupled glutamate receptor signaling pathway
metabotropic glutamate receptor signaling pathway
metabotropic glutamate receptor signalling pathway
A G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. Tachykinin is a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2).
tachykinin signalling pathway
A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
neuropeptide signalling pathway
The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
N signaling pathway
N signalling pathway
Notch receptor signaling pathway
Notch receptor signalling pathway
Notch signalling pathway
Notch-receptor signaling pathway
Notch-receptor signalling pathway
The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor.
N receptor processing
A type of non-canonical Wnt signaling in which Wnt binding to its receptor on the surface of a target cell leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
frizzled-2 signaling pathway
frizzled-2 signalling pathway
non-canonical Wnt signaling pathway
Wnt receptor signaling pathway, calcium modulating pathway
Wnt-activated signaling pathway, calcium modulating pathway
The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
hedgehog signaling pathway
hh signaling pathway
hh signalling pathway
Shh signaling pathway
smoothened signalling pathway
Sonic hedgehog signaling pathway
The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
integrin-mediated signalling pathway
The series of molecular signals initiated in response to osmotic change.
osmolarity sensing
osmolarity sensing signaling pathway
osmolarity sensing signalling pathway
osmosensory signal transduction
osmosensory signalling pathway
signal transduction during osmotic stress
An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs).
canonical NF-kappaB signaling cascade
I-kappaB kinase/NF-kappaB cascade
I-kappaB kinase/NF-kappaB signal transduction
I-kappaB kinase/NF-kappaB signaling
NF-kappaB cascade
p50-dependent NF-kappaB signaling
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
IkappaB phosphorylation
IKB phosphorylation
inhibitor of kappaB phosphorylation
inhibitor of NF-kappaB phosphorylation
A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
c-Jun N-terminal kinase cascade
JNK1 cascade
JNK2 cascade
JNK3 cascade
MAPK10 cascade
MAPK8 cascade
MAPK9 cascade
SAPK cascade
stress-activated protein kinase cascade
A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
JAK-STAT cascade
JAK-STAT signal transduction
receptor signaling pathway via JAK-STAT
The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
tyrosine phosphorylation of Stat1 protein
tyrosine phosphorylation of Stat2 protein
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat4 protein
tyrosine phosphorylation of Stat5 protein
tyrosine phosphorylation of Stat6 protein
tyrosine phosphorylation of Stat7 protein
An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
nitric oxide signaling
nitric oxide-mediated signal transduction
NO mediated signal transduction
NO-mediated signal transduction
An intracellular signaling cassette in which a small monomeric GTPase relays a signal.
Ras family protein signal transduction
small GTPase mediated signal transduction
An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal.
Ras mediated signal transduction
An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal.
Rho mediated signal transduction
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
cell-cell signalling
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
neurotransmission
signal transmission across a synapse
synaptic transmission
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
neurotransmitter release
neurotransmitter secretory pathway
The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
cholinergic synaptic transmission
The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment.
ionic insulation of neurons by glial cells
The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
gametogenesis
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
gametogenesis
germ-cell development
primordial germ cell development
Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells.
cystoblast cell division
The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
generation of spermatozoa  systematic_synonym
The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
spermatid cell development
spermiogenesis
The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization.
spermatid nuclear differentiation
Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster.
egg chamber growth
The production of yolk. Yolk is a mixture of materials used for embryonic nutrition.
yolk formation
yolk production  systematic_synonym
The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster.
follicle cell migration
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
border cell migration
Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster.
nurse cell to oocyte transport
Assembly of the intercellular bridges that connect the germ-line cells of a female cyst.
nurse cell ring canal formation
ovarian ring canal formation
The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster.
eggshell formation
Construction of the chorion portion of the egg, which is a protective, noncellular membrane that surrounds the eggs of various animals including insects and fish.
eggshell chorion formation
insect chorion formation
The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster.
oocyte arrangement
The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.
oocyte axis determination
The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster.
oocyte dorsal-ventral axis specification
oocyte dorsal/ventral axis determination
oocyte dorsoventral axis specification
Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.
oocyte anterior/posterior axis determination
Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.
establishment and maintenance of pole plasm RNA localization
oocyte pole plasm RNA localization
pole plasm RNA localisation
Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.
regulation of oocyte pole plasm oskar mRNA localization
regulation of pole plasm oskar mRNA localisation
The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae.
pheromone processing
The union of male and female gametes to form a zygote.
zygote biosynthesis
zygote formation
The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.
ZPG binding
The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.
sperm-oocyte fusion