NothingMuch/GO-Terms huggingface dataset:
Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction.
down regulation of Rac protein signal transduction
down-regulation of Rac protein signal transduction
downregulation of Rac protein signal transduction
inhibition of Rac protein signal transduction
Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction.
activation of Rac protein signal transduction
stimulation of Rac protein signal transduction
up regulation of Rac protein signal transduction
up-regulation of Rac protein signal transduction
upregulation of Rac protein signal transduction
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
down regulation of Rho protein signal transduction
down-regulation of Rho protein signal transduction
downregulation of Rho protein signal transduction
inhibition of Rho protein signal transduction
Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
activation of Rho protein signal transduction
stimulation of Rho protein signal transduction
up regulation of Rho protein signal transduction
up-regulation of Rho protein signal transduction
upregulation of Rho protein signal transduction
Binds to and modulates the activity of histone acetyltransferase.
histone acetylase regulator activity
Binding to an histone acetyltransferase.
histone acetylase binding
Unwinding of the condensed nuclear chromatin of an inactive male pronucleus after fertilization.
sperm chromatin decondensation
The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg.
sperm plasma membrane breakdown
sperm plasma membrane catabolism
sperm plasma membrane degradation
A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4.
replication-coupling assembly factor complex
A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof.
BRM complex
A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs).
ICG
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized.
nuclear speck organisation
nuclear speck organization and biogenesis
nuclear speckle assembly
nuclear speckle organization
The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly.
salivary gland regression
The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period.
head eversion
prepupal-pupal transition
The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication.
sperm chromatin condensation
spermatogenesis, exchange of chromosomal proteins
Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
behavioural response to nicotine
The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ.
larval midgut cell death
programmed cell death of larval midgut cells
A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.
Extra Sex Combs/Enhancer of Zeste complex
polycomb repressive complex 2
PRC2 complex
The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo.
arthropod blood cell migration
hemocyte cell migration
A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage.
Facilitates chromatin transcription complex
A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
Polycomb repressive complex 1
Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior.
instrumental conditioning
The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.
embryonic arm morphogenesis
Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint.
tracheal branch fusion
Creation of the central hole of a tube in an open tracheal system through which gases flow.
tracheal lumen formation
Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates.
down regulation of terminal cell fate specification
down-regulation of terminal cell fate specification
downregulation of terminal cell fate specification
inhibition of terminal cell fate specification
negative regulation of terminal cell fate specification
Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates.
down regulation of fusion cell fate specification
down-regulation of fusion cell fate specification
downregulation of fusion cell fate specification
inhibition of fusion cell fate specification
Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size.
regulation of tracheal tube diameter
tracheal tube dilation
tracheal tube expansion
Ensuring that a tube in an open tracheal system is of the correct length.
regulation of tracheal tube length
tracheal tube elongation
Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process.
maintenance of tracheal epithelial integrity
The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte.
embryonic plasmatocyte cell differentiation
The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte.
lymph gland plasmatocyte cell differentiation
Catalysis of the reaction: histone H3-serine (position 10) + ATP = histone H3-phosphoserine (position 10) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 10 of histone H3.
histone kinase activity (H3-S10 specific)
histone serine kinase activity (H3-S10 specific)
histone-serine kinase activity (H3-S10 specific)
The movement of a larva through a feeding substrate whilst feeding on food.
larval foraging behaviour
Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source.
turning behaviour
The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction.
larval wandering behaviour
Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation.
larval burrowing behaviour
An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues.
germline ring canal outer rim
nurse cell ring canal outer rim
ovarian ring canal outer rim
A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins.
germline ring canal inner rim
nurse cell ring canal inner rim
ovarian ring canal inner rim
The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell.
hatching behaviour
A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression.
retinoblastoma-E2F complex
The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex.
nuclear distribution along anterior-posterior axis
nucleus distribution along anterior-posterior axis
Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster.
central nervous system metamorphosis
CNS metamorphosis
larval central nervous system remodelling
Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
small interfering RNA binding
The specific avoidance actions or reactions of an organism in response to the perception of salt.
behavioral response to salt
Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster.
tracheal placode invagination
tracheal sac formation
Any process that stops, prevents, or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes.
down regulation of lamellocyte differentiation
down-regulation of lamellocyte differentiation
downregulation of lamellocyte differentiation
inhibition of lamellocyte differentiation
Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes.
activation of lamellocyte differentiation
stimulation of lamellocyte differentiation
up regulation of lamellocyte differentiation
up-regulation of lamellocyte differentiation
upregulation of lamellocyte differentiation
Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.
down regulation of hemocyte proliferation
down-regulation of hemocyte proliferation
downregulation of hemocyte proliferation
inhibition of hemocyte proliferation
negative regulation of arthropod blood cell proliferation
Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster.
activation of hemocyte proliferation
positive regulation of arthropod blood cell proliferation
stimulation of hemocyte proliferation
up regulation of hemocyte proliferation
up-regulation of hemocyte proliferation
upregulation of hemocyte proliferation
Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.
activation of glutamate-cysteine ligase activity
stimulation of glutamate-cysteine ligase activity
up regulation of glutamate-cysteine ligase activity
up-regulation of glutamate-cysteine ligase activity
upregulation of glutamate-cysteine ligase activity
A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um.
membrane nanotube
Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell.
cytoneme biogenesis
Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.
programmed cell death of ectopic germ cells
programmed cell death, ectopic germ cells
The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals cannot synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids.
vitamin A anabolism
vitamin A biosynthesis
vitamin A formation
vitamin A synthesis
Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + -L-arginine = S-adenosyl-L-homocysteine + -Nomega-methyl-L-arginine.
protein arginine omega-N monomethylase activity
S-adenosyl-L-methionine:-L-arginine N-methyltransferase (-Nomega-methyl-L-arginine-forming)
type III protein arginine methyltransferase activity
Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues.
protein arginine omega-N asymmetric methylase activity
protein arginine omega-N asymmetric methyltransferase activity
S-adenosyl-L-methionine:-L-arginine N-methyltransferase (-Nomega,Nomega-dimethyl-L-arginine-forming)
type I PRMT activity
type I protein arginine methyltransferase activity
Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.
protein arginine omega-N symmetric methylase activity
protein arginine omega-N symmetric methyltransferase activity
S-adenosyl-L-methionine:-L-arginine N-methyltransferase (-Nomega,Nomega\'-dimethyl-L-arginine-forming)
type II PRMT activity
type II protein arginine methyltransferase activity
Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein. This modification has been detected in anaerobic bacteria.
peptidyl arginine C-methyltransferase activity
peptidyl-arginine C-methylase activity
peptidyl-arginine C-methyltransferase activity
protein-arginine C-methylase activity
Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage.
alpha-1,4-GalNAc transferase activity
A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm.
cilial rootlet
cilium rootlet
A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
TIP60 histone acetylase complex
TIP60 histone acetyltransferase complex
The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.
protein amino acid O-linked mannosylation
Binding to diphenyl phthalate, C(20)H(14)O(4).
DPP binding
Binding to dibutyl phthalate, C(16)H(22)O(4).
DBP binding
phthalic acid dibutyl ester binding
The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk.
spiracle morphogenesis
An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs.
down regulation of translation involved in gene silencing by miRNA
down-regulation of translation involved in gene silencing by miRNA
downregulation of translation involved in gene silencing by miRNA
gene silencing by miRNA, negative regulation of translation
inhibition of translation involved in gene silencing by miRNA
miRNA mediated inhibition of translation
miRNA-mediated gene silencing, negative regulation of translation
negative regulation of translation involved in gene silencing by microRNA
An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism.
deadenylation involved in gene silencing by miRNA
gene silencing by miRNA, mRNA cleavage
gene silencing by mRNA cleavage
miRNA-mediated gene silencing by mRNA deadenylation
miRNA-mediated gene silencing, mRNA cleavage
mRNA cleavage involved in gene silencing by microRNA
mRNA cleavage involved in gene silencing by miRNA
mRNA deadenylation-mediated gene silencing by miRNA
mRNA destabilization-mediated gene silencing by miRNA
Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product.
pre-microRNA export from cell nucleus
pre-microRNA export from nucleus
pre-microRNA export out of nucleus
pre-microRNA transport from nucleus to cytoplasm
pre-microRNA-nucleus export
Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H+.
inositol hexakisphosphate synthase
inositol pentakisphosphate 2-kinase activity
inositol polyphosphate kinase activity
inositol-pentakisphosphate 2-kinase activity
Ins(1,3,4,5,6)P5 2-kinase activity
IP5 2-kinase activity
A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila).
Hedgehog signalling complex
HSC
Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair.
wing hair outgrowth
wing prehair outgrowth
Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles.
wing hair elongation
wing prehair extension
Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally.
prehair localization
wing hair site selection
Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity.
maintenance of wing hair orientation
An intercellular bridge that connects the germline cells of a male cyst.
spermatocyte ring canal
testicular ring canal
Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.
negative regulation of hippo signaling cascade
negative regulation of hippo signaling pathway
negative regulation of hippo signalling cascade
Any process that activates or increases the frequency, rate or extent of hippo signaling.
positive regulation of hippo signaling cascade
positive regulation of hippo signaling pathway
positive regulation of hippo signalling cascade