NothingMuch/GO-Terms huggingface dataset:
The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.
actin rod formation
A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.
poly(A) nuclease complex
The portion of the plasma membrane surrounding a uropod.
uropodium membrane
An essential outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis.
Nuf2-Ndc80 complex
A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor.
CD95 death-inducing signalling complex
CD95 DISC
Fas death-inducing signaling complex
A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor.
TRAIL death-inducing signalling complex
TRAIL DISC
Binding to a small monomeric GTPase.
ADP-ribosylation factor binding
ARF binding
GTP-Ral binding
GTP-Rho binding
Rab escort protein activity
Rab GTPase binding
Rab interactor activity
Rac GTPase binding
Ral GTPase binding
Ran GTPase binding
Ran protein binding
Ran-binding protein
Ras GTPase binding
Ras interactor activity
REP
Rho GTPase binding
The extension of a pseudopodium from the lateral area of a cell.
lateral pseudopodium formation
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia.
down regulation of pseudopodium formation
down-regulation of pseudopodium formation
downregulation of pseudopodium formation
inhibition of pseudopodium formation
negative regulation of pseudopodium formation
Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.
activation of pseudopodium formation
positive regulation of pseudopodium formation
stimulation of pseudopodium formation
up regulation of pseudopodium formation
up-regulation of pseudopodium formation
upregulation of pseudopodium formation
Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity.
down regulation of guanylate cyclase activity
down-regulation of guanylate cyclase activity
downregulation of guanylate cyclase activity
inhibition of guanylate cyclase activity
Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.
activation of guanylate cyclase activity
stimulation of guanylate cyclase activity
up regulation of guanylate cyclase activity
up-regulation of guanylate cyclase activity
upregulation of guanylate cyclase activity
Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.
down regulation of stalk cell differentiation
down-regulation of stalk cell differentiation
downregulation of stalk cell differentiation
inhibition of stalk cell differentiation
negative regulation of stalk cell differentiation
Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.
activation of stalk cell differentiation
positive regulation of stalk cell differentiation
stimulation of stalk cell differentiation
up regulation of stalk cell differentiation
up-regulation of stalk cell differentiation
upregulation of stalk cell differentiation
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation.
B cell co-stimulation
B lymphocyte co-stimulation
B lymphocyte costimulation
B-cell co-stimulation
B-cell costimulation
B-lymphocyte co-stimulation
B-lymphocyte costimulation
A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.
replisome progression complex
Swi1-Swi3 complex
TIMELESS-TIPIN complex
Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde.
taurine:pyruvate aminotransferase activity
Tpa
The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic to mitochondrial outer membrane
The component of a nuclear outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic to nuclear outer membrane
A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients.
TRAP transporter complex
TRAP-T transporter complex
The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal.
detection of folate
folate detection
folate sensing
folic acid detection
folic acid sensing
The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP.
3\',5\'-cAMP detection
3\',5\'-cAMP sensing
cAMP detection
cAMP sensing
cyclic AMP detection
detection of 3\',5\' cAMP
detection of 3\',5\'-cAMP
detection of adenosine 3\',5\'-cyclophosphate
detection of cyclic AMP
A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP).
ascospore-type prospore-specific spindle pole body modification
ascospore-type prospore-specific spindle pole body remodelling
forespore specific spindle pole body remodeling
forespore-specific spindle pole body remodeling
prospore-specific spindle pole body remodeling
sporulation-specific spindle pole body remodeling
Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.
eIF4G binding
A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains. In Saccharomyces cerevisiae, the complex comprises Ubc13p and Mms2p; in human it comprises UBE2N and UBE2V1/UBE2V2; and in plants UBC35/UBC36 and UEV1A/UEV1B/UEV1C/UEV1D-4.
BEN-UEV1A complex
ubc-13-uev-1 complex
UBE2N/UBE2NL complex
UBE2V1/UBE2V2 complex
Uev1A-ben complex
A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain.
Rdr1 complex
RDRC
A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.
covalent modifier
protein tag
protein tagging activity
ubiquitin
ubiquitin-like protein modifier
A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.
Rad17-RFC
Rad17-RLC
Rad24p RFC-like complex
RFC (Rad17)
A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p.
Ctf18-RFC
Ctf18-RLC
RFC (Ctf18)
A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.
Elg1-RFC
Elg1-RLC
RFC (Elg1)
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.
down regulation of prostaglandin biosynthetic process
down-regulation of prostaglandin biosynthetic process
downregulation of prostaglandin biosynthetic process
inhibition of prostaglandin biosynthetic process
negative regulation of prostaglandin anabolism
negative regulation of prostaglandin biosynthesis
negative regulation of prostaglandin formation
negative regulation of prostaglandin synthesis
Binding to a sodium ion (Na+).
Na+ ion binding
Binding to a lithium ion (Li+).
Li+ ion binding
Binding to a chloride ion (Cl-).
chloride binding
Cl- ion binding
The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.
oxylipin anabolism
oxylipin biosynthesis
oxylipin formation
oxylipin synthesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps.
gas vesicle biosynthesis
gas vesicle formation
gas vesicle organisation
gas vesicle organization and biogenesis
Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases.
buoyancy regulation
A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins.
N-terminal acetyltransferase A complex
A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p.
N-terminal acetyltransferase B complex
A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p.
N-terminal acetyltransferase C complex
Binding to L-ascorbic acid, (2R)-2--4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
L-ascorbate binding
vitamin C binding
Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
vitamin B12 binding
A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human.
RecQ helicase-Topo III complex
Sgs1-Top3 complex
A ribonucleoprotein complex containing a box C/D type RNA that is capable of ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya.
box C/D small nucleolar ribonucleoprotein complex
box C/D snoRNP complex
box C/D snoRNP ribose 2\'-O methylase complex
box C/D snoRNP ribose-2\'-O-methyltransferase complex
box C/D sRNP complex
A box H/ACA small nucleolar ribonucleoprotein complex located in the nucleolus that catalyzes pseudouridylation of ribosomal RNA residues. The complex is composed of four different core proteins that assemble onto a H/ACA guide RNA scaffold that identifies specific uridines in rRNA for modification during ribosome synthesis.
box H/ACA small nucleolar ribonucleoprotein complex
box H/ACA snoRNP pseudouridylase complex
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
M disc
M line
mesophragma
midline
A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
Cdc7-Dbf4 complex
DDK
Hsk1-Dfp1 kinase complex
Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase.
MAPKK binding
Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase.
MAPKKK binding
Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing.
down regulation of mRNA 3\'-end processing
down-regulation of mRNA 3\'-end processing
downregulation of mRNA 3\'-end processing
inhibition of mRNA 3\'-end processing
Any process that stops, prevents, or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction.
down regulation of fast-twitch skeletal muscle contraction
down-regulation of fast-twitch skeletal muscle contraction
downregulation of fast-twitch skeletal muscle contraction
inhibition of fast-twitch skeletal muscle contraction
negative regulation of fast-twitch skeletal muscle contraction
Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction.
activation of fast-twitch skeletal muscle contraction
positive regulation of fast-twitch skeletal muscle contraction
stimulation of fast-twitch skeletal muscle contraction
up regulation of fast-twitch skeletal muscle contraction
up-regulation of fast-twitch skeletal muscle contraction
upregulation of fast-twitch skeletal muscle contraction
Any process that stops, prevents, or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction.
down regulation of slow-twitch skeletal muscle contraction
down-regulation of slow-twitch skeletal muscle contraction
downregulation of slow-twitch skeletal muscle contraction
inhibition of slow-twitch skeletal muscle contraction
negative regulation of slow-twitch skeletal muscle contraction
Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction.
activation of slow-twitch skeletal muscle contraction
positive regulation of slow-twitch skeletal muscle contraction
stimulation of slow-twitch skeletal muscle contraction
up regulation of slow-twitch skeletal muscle contraction
up-regulation of slow-twitch skeletal muscle contraction
upregulation of slow-twitch skeletal muscle contraction
The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine.
glycine betaine breakdown
glycine betaine catabolism
glycine betaine degradation
N-trimethylglycine catabolic process
N-trimethylglycine catabolism
Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in).
ABC-type betaine transmembrane transporter activity
ATP-dependent betaine transporter activity
ATPase-coupled betaine transporter activity
betaine ABC transporter
betaine-transporting ATPase activity
Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in).
ATP-dependent glycine betaine transporter activity
ATPase-coupled glycine betaine transporter activity
glycine betaine ABC transporter
glycine betaine-transporting ATPase activity
N-trimethylglycine-transporting ATPase activity
The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
N-trimethylglycine transport
A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
CBC complex
CDL2 complex
CRL2 complex
cullin-RING ligase 2
EC2S complex
ECS complex
SCF2 complex
VBC complex
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
BC3B complex
BCR3 complex
CDL3 complex
CRL3 complex
cullin-RING ligase 3
SCF3 complex
A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
CDL4 complex
CRL4 complex
cullin-RING ligase 4A
DCX complex
SCF4 complex
VDC complex
A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits.
cullin-RING ligase 4B
A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
CDL5 complex
CRL5 complex
cullin-RING ligase 5
EC2S complex
SCF5 complex
A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein.
CDL7 complex
CRL7 complex
cullin-RING ligase 7
SCF7 complex
An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase.
ethanolamine metabolosome
Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching.
down regulation of mating type switching
down-regulation of mating type switching
downregulation of mating type switching
inhibition of mating type switching
Any process that activates or increases the frequency, rate or extent of mating type switching.
activation of mating type switching
stimulation of mating type switching
up regulation of mating type switching
up-regulation of mating type switching
upregulation of mating type switching
A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control.
TRAMP4 complex
TRAMP5 complex
Trf4 complex
Trf4 poly(A) polymerase complex
Trf4p-Air2p-Mtr4p polyadenylation complex
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall.
peptidoglycan-based cell wall organisation
peptidoglycan-based cell wall organization and biogenesis
The compaction of chromatin into heterochromatin at the subtelomeric region.
chromatin silencing at subtelomere
chromatin silencing at telomere
establishment of chromatin silencing at telomere
heterochromatic silencing at subtelomere
heterochromatic silencing at telomere
regulation of chromatin silencing at telomere
regulation of subtelomeric heterochromatin assembly
subtelomere chromatin silencing
subtelomeric heterochromatin assembly
subtelomeric silencing
telomere chromatin silencing
Telomere Position Effect
telomeric heterochromatin assembly
telomeric heterochromatin formation
telomeric silencing
A conserved heterodimeric complex with SUMO activating enzyme activity.
SAE
SUMO E1 activator enzyme complex
A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.
Mcm21
Mis6 centromere subcomplex
Mis6-Mal2-Sim4 centromere complex
Sim4 complex
A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC.
plasma membrane Sec complex
Sec complex
Sec secretion complex
Sec translocation complex
A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression.
Myeloblastosis proto-oncogene protein complex
The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol.
menthol anabolism
menthol biosynthesis
menthol formation
menthol synthesis
Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.
GnRH receptor binding
gonadotrophin-releasing hormone receptor binding
Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary.
thyrotropin releasing hormone receptor binding
thyrotropin-releasing hormone receptor ligand
Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
activation of exit from mitosis
stimulation of exit from mitosis
up regulation of exit from mitosis
up-regulation of exit from mitosis
upregulation of exit from mitosis
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins.
down regulation of anthocyanin biosynthetic process
down-regulation of anthocyanin biosynthetic process
downregulation of anthocyanin biosynthetic process
inhibition of anthocyanin biosynthetic process
negative regulation of anthocyanin anabolism
negative regulation of anthocyanin biosynthesis
negative regulation of anthocyanin formation
negative regulation of anthocyanin synthesis
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins.
activation of anthocyanin biosynthetic process
positive regulation of anthocyanin anabolism
positive regulation of anthocyanin biosynthesis
positive regulation of anthocyanin formation
positive regulation of anthocyanin synthesis
stimulation of anthocyanin biosynthetic process
up regulation of anthocyanin biosynthetic process
up-regulation of anthocyanin biosynthetic process
upregulation of anthocyanin biosynthetic process
Binding to a brain-derived neurotrophic factor receptor.
BDNF receptor binding
brain-derived neurotrophic factor ligand