NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate.
2,3-bisphospho-D-glycerate 3-phosphohydrolase activity
The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine.
urate anabolism
urate biosynthesis
urate formation
urate synthesis
uric acid biosynthetic process
The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome.
post-translational protein amino acid acetylation
posttranslational protein amino acid acetylation
The volume enclosed within the autophagosome double-membrane.
autophagic vacuole lumen
The single layer of phopholipids surrounding a lipid storage body.
lipid droplet outer lipid monolayer
lipid storage body surface lipid monolayer
oil body outer lipid monolayer
oleosome outer lipid monolayer
spherosome outer lipid monolayer
Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate.
AP(6)A hydrolase activity
AP-6-A hydrolase activity
AP6A hydrolase activity
diadenosine 5\',5\'\'\'-P1,P6-hexaphosphate hydrolase activity
Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate.
AP(5)A hydrolase activity
AP-5-A hydrolase activity
AP5A hydrolase activity
Ap5a pyrophosphohydrolase activity
diadenosine 5\',5\'\'\'-P1,P6-pentaphosphate hydrolase activity
Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein particle oxidation, occurring in the blood plasma.
inhibition of plasma lipoprotein oxidation
negative regulation of plasma lipoprotein particle oxidation
Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
E4
A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p.
Nan1p-containing subcomplex of 90S preribosome
A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p.
Rrp7p-containing subcomplex of 90S preribosome
Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis.
3\' to 5\' RNA helicase activity
ATP-dependent 3\' to 5\' RNA helicase activity
ATP-dependent 3\'-5\' RNA helicase activity
The assembly of a uropod by rearrangement of the cytoskeleton and overlying membrane.
uropod formation
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome.
small subunit processome assembly
SSU processome assembly
A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B.
Bardet-Biedl syndrome complex
Any process involved in forming the mature 3' end of a U1 snRNA molecule.
U1 snRNA 3\' end processing
Any process involved in forming the mature 3' end of a U2 snRNA molecule.
U2 snRNA 3\' end processing
Any process involved in forming the mature 3' end of a U4 snRNA molecule.
U4 snRNA 3\' end processing
Any process involved in forming the mature 3' end of a U5 snRNA molecule.
U5 snRNA 3\' end processing
Any process involved in forming the mature 3' end of a U6 snRNA molecule.
U6 snRNA 3\' end processing
The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
phosphatidylglycerol breakdown
phosphatidylglycerol catabolism
phosphatidylglycerol degradation
Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H+ + phosphocholine.
Clostridium oedematiens beta- and gamma-toxins activity
Clostridium welchii alpha-toxin activity
heat-labile hemolysin
lipophosphodiesterase I activity
phosphatidylcholine cholinephosphohydrolase activity
phospholipase C, acting on phosphatidylcholine
Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues.
chondroitin 2-O-sulphotransferase activity
chondroitin 2-sulfotransferase activity
The controlled breakdown of the membranes of multivesicular bodies.
MVB membrane disassembly
Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS).
protein localisation to phagophore assembly site
protein localization to PAS
protein localization to pre-autophagosomal structure
The directed movement of substances from early endosomes to the Golgi.
PGE to Golgi transport
post-Golgi endosome to Golgi transport
The directed movement of substances from late endosomes to the Golgi.
prevacuolar endosome to Golgi transport
PVE to Golgi transport
Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus.
condensin localization to nucleolar rDNA repeats
protein localisation to nucleolar rDNA repeats
Binding to a box C/D small nucleolar RNA.
box C/D snoRNA binding
box C/D sRNA binding
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins.
mtUPR
An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state.
PSG
The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane.
mitochondrial cytochrome bc(1) complex assembly
Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O.
o-hydroxylaminobenzoate nitroreductase activity
Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
Piwi-associated RNA binding
The chemical reactions and pathways resulting in the breakdown of 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome.
21U-RNA breakdown
21U-RNA catabolism
21U-RNA degradation
The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4-hydroxyproline transport
L-hydroxyproline transport
Enables the transfer of L-hydroxyproline from one side of a membrane to the other.
4-hydroxyproline transmembrane transporter activity
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity
phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity
Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates.
DNA oligonucleotidase activity
Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates.
RNA oligonucleotidase activity
A protein complex that possesses GTP cyclohydrolase I activity. In E. coli and human, the complex is a homodecamer, and monomers are catalytically inactive.
GTP cyclohydrolase I complex
Binding to 2-amino-5-(carbamimidamido)pentanoic acid.
aminopentanoic acid binding
Arg binding
The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.
de novo NAD biosynthetic process from aspartate
nicotinamide nucleotide anabolism from aspartate
nicotinamide nucleotide biosynthetic process from aspartate
nicotinamide nucleotide formation from aspartate
nicotinamide nucleotide synthesis from aspartate
Any process in which a RITS complex is transported to, or maintained in, a specific location.
establishment and maintenance of RITS complex localization
RITS complex localisation
Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A.
retinol transporter activity
vitamin A1 transporter activity
The directed movement of retinol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A.
vitamin A1 transport
The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization.
establishment of mitochondrion localisation by microtubule attachment
mitochondrial localization by microtubule attachment
mitochondrial migration by microtubule attachment
mitochondrion migration by microtubule attachment
The directed movement of a mitochondrion along a microfilament, mediated by motor proteins.
mitochondrial migration along actin filament
mitochondrial migration along microfilament
mitochondrial migration, actin-mediated
mitochondrion migration along microfilament
mitochondrion transport along actin filament
Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
H3K4me3 demethylase activity
histone demethylase activity (H3-K4-me3 specific)
histone demethylase activity (H3-trimethyl-K4 specific)
histone H3-K4me2 demethylase activity
histone H3-K4me3 demethylase activity
histone H3-tri/di/monomethyl-lysine-4 demethylase activity
histone H3K4me2 demethylase activity
The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A.
retinoic acid breakdown
retinoic acid catabolism
retinoic acid degradation
vitamin A1 acid catabolic process
A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species.
C-terminal to LisH complex
CTLH complex
A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1.
endoplasmic reticulum network complex
ER chaperone complex
ER network complex
A protein complex that is located in the endoplasmic reticulum (ER) and is formed by the association of an immunoglobulin heavy chain with the proteins of the ER chaperone complex; the latter include BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1.
Ig heavy chain-bound ER chaperone complex
immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex
An integrin complex that comprises one alpha1 subunit and one beta1 subunit.
alpha1-beta1 integrin complex
ITGA1-ITGB1 complex
VLA-1 complex
An integrin complex that comprises one alpha2 subunit and one beta1 subunit.
ITGA2-ITGB1 complex
VLA-2 complex
An integrin complex that comprises one alpha3 subunit and one beta1 subunit.
alpha3-beta1 integrin complex
ITGA3-ITGB1 complex
VLA-3 complex
An integrin complex that comprises one alpha4 subunit and one beta1 subunit.
alpha4-beta1 integrin complex
ITGA4-ITGB1 complex
VLA-4 complex
An integrin complex that comprises one alpha4 subunit and one beta7 subunit.
alpha4-beta7 integrin complex
ITGA4-ITGB7 complex
The developmental process that results in the creation of defined areas or spaces within the pronephros along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate.
anterior/posterior pattern specification involved in pronephric kidney development
An integrin complex that comprises one alpha5 subunit and one beta1 subunit.
alpha5-beta1 integrin complex
ITGA5-ITGB1 complex
VLA-5 complex
An integrin complex that comprises one alpha6 subunit and one beta1 subunit.
alpha6-beta1 integrin complex
ITGA6-ITGB1 complex
VLA-6 complex
An integrin complex that comprises one alpha6 subunit and one beta4 subunit.
alpha6-beta4 integrin complex
ITGA6-ITGB4 complex
An integrin complex that comprises one alpha7 subunit and one beta1 subunit.
alpha7-beta1 integrin complex
ITGA7-ITGB1 complex
An integrin complex that comprises one alpha8 subunit and one beta1 subunit.
alpha8-beta1 integrin complex
ITGA8-ITGB1 complex
An integrin complex that comprises one alpha9 subunit and one beta1 subunit.
alpha9-beta1 integrin complex
ITGA9-ITGB1 complex
An integrin complex that comprises one alpha10 subunit and one beta1 subunit.
alpha10-beta1 integrin complex
ITGA10-ITGB1 complex
An integrin complex that comprises one alpha11 subunit and one beta1 subunit.
alpha11-beta1 integrin complex
ITGA11-ITGB1 complex
An integrin complex that comprises one alphav subunit and one beta1 subunit.
alphav-beta1 integrin complex
ITGAV-ITGB1 complex
An integrin complex that comprises one alphav subunit and one beta3 subunit.
alphav-beta3 integrin complex
ITGAV-ITGB3 complex
An integrin complex that comprises one alphav subunit and one beta5 subunit.
alphav-beta5 integrin complex
ITGAV-ITGB5 complex
An integrin complex that comprises one alphav subunit and one beta6 subunit.
alphav-beta6 integrin complex
ITGAV-ITGB6 complex
An integrin complex that comprises one alphav subunit and one beta8 subunit.
alphav-beta8 integrin complex
ITGAV-ITGB8 complex
An integrin complex that comprises one alphaL subunit and one beta2 subunit.
alphaL-beta2 integrin complex
Itgal-Itgb2 complex
An integrin complex that comprises one alphaM subunit and one beta2 subunit.
alphaM-beta2 integrin complex
Itgam-Itgb2 complex
An integrin complex that comprises one alphaX subunit and one beta2 subunit.
alphaX-beta2 integrin complex
Itgax-Itgb2 complex
An integrin complex that comprises one alphaD subunit and one beta2 subunit.
alphaD-beta2 integrin complex
Itgad-Itgb2 complex
An integrin complex that comprises one alphaE subunit and one beta7 subunit.
Itgae-Itgb7 complex
A ribonucleoprotein complex that is formed by the association of the U11 and U12 small nuclear ribonucleoproteins.
18S U11/U12 snRNP
snRNP U11/U12
A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
20S methylosome
20S methyltransferase complex
Binding to an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers.
inhibin alpha binding
inhibin beta-A binding
inhibin beta-B binding
inhibin monomer binding
Binding to a type I transforming growth factor beta receptor.
babo binding
babo ligand
baboon binding
baboon ligand
baboon receptor ligand
sax binding
sax ligand
saxophone binding
saxophone ligand
TGF-beta type I binding
thickveins binding
thickveins ligand
tkv binding
tkv ligand
transforming growth factor beta ligand binding to type I receptor
transforming growth factor beta receptor type I binding
type I TGF-beta binding
Binding to a type III transforming growth factor beta receptor.
betaglycan binding
TGF-beta type III binding
transforming growth factor beta ligand binding to type III receptor
transforming growth factor beta receptor type III binding
type IIII TGF-beta binding
A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.
6S pICln complex
Catalysis of the cleavage of a gamma-linked glutamate bond.
gamma-glutamyl hydrolase activity
Degradation of a cell nucleus by microautophagy.
PMN
An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex.
SMN-containing protein complex
An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA.
SMN-containing protein complex
Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA.
ACAT activity
acyl coenzyme A-cholesterol-O-acyltransferase activity
acyl-CoA:cholesterol acyltransferase activity
acyl-CoA:cholesterol O-acyltransferase activity
acylcoenzyme A:cholesterol O-acyltransferase activity
cholesterol acyltransferase activity
cholesterol ester synthetase activity
cholesteryl ester synthetase activity
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.
histone deacetylase activity (H4-K16 specific)
histone H4-K16 deacetylase activity
histone H4K12 deacetylase activity
A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III.
TFIIIC-Topoisomerase 1-PC4 complex
A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization.
60S APC complex
A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation.
hScrib-APC complex
A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation.
hScrib-APC-beta-catenin complex
An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP.
9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex
cytosolic AhR complex
cytosolic AHRC
An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT).
6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex
nuclear AhR complex
nuclear AHRC
A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p.
HDAC3 complex
SET3C
A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex.
Dbf2p-Mob1p complex
Sid2-Mob1 kinase complex
Sid2p-Mob1p complex
A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching.
Swi5 complex
A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages.
ABIN2-NFKB1-TPL-1 complex
A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes.
acinar cell-specific C complex
The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.
protein lysine acetylation
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches.
MAS organization
microtubule organising centre attachment site organisation
MTOC attachment site organization
A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation.
p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated
A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin.
ITGAV-ITGB5-VTN complex
Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system.
dorsal trunk growth
The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system.
tracheal liquid clearance
The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.
SAC
Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + H+.
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity
C2-domain-containing phosphoinositide 3-kinase activity
phosphatidylinositol 3-kinase activity, class I
phosphatidylinositol 3-kinase activity, class II
phosphatidylinositol 3-kinase, class I, catalyst activity
phosphatidylinositol-4-phosphate 3-kinase activity
type II phosphoinositide 3-kinase activity
Any process that increases the rate or extent of the melanization defense response during injury or invasion.
activation of melanization defense response
positive regulation of melanization defence response
stimulation of melanization defense response
up regulation of melanization defense response
up-regulation of melanization defense response
upregulation of melanization defense response
The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle. An example of this process is adult chitin-based cuticle pattern formation in Drosophila melanogaster.
adult cuticle pattern formation