NothingMuch/GO-Terms huggingface dataset:
The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine.
mcm5 modification
mcm5s2U34 biosynthesis
tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis
A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II.
meta-coactivator complex
The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid.
fatty acid hydroxylation
Catalysis of the reaction: adenosine37 in tRNA + 2 reduced - + 2 S-adenosyl-L-methionine = 2-methyladenosine37 in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized - + S-adenosyl-L-homocysteine.
tRNA (adenine(37)-C(2))-methyltransferase activity
tRNA (adenosine(37)-C2-)-methyltransferase activity
The process whereby a guanine in tRNA is methylated at position N1 of the guanine.
tRNA m1-guanine biosynthesis
The process whereby a guanine in a tRNA is methylated at the N2 position of guanine.
tRNA m2-guanine biosynthesis
A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
CycK/Cdk12 complex
A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
CycK/Cdk13 complex
A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily.
TNF receptor superfamily complex
Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA.
ArcS
glutamine:preQ0-tRNA amidinotransferase
Catalysis of the reaction: (2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate.
phospho-AI-2 isomerase activity
The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis.
follicular fluid formation in ovarian follicle antrum during fused antrum stage
The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis.
follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage
The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis.
follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage
The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control.
aortic arch baroreceptor control of systemic arterial blood pressure
The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body.
detection of increased carbon dioxide by aortic body chemoreceptor signalling
The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body.
detection of increased carbon dioxide by carotid body chemoreceptor signalling
The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body.
detection of pH by aortic body chemoreceptor signalling
The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body.
detection of pH by carotid body chemoreceptor signalling
The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body.
detection of reduced oxygen by aortic body chemoreceptor signalling
The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body.
detection of reduced oxygen by carotid body chemoreceptor signalling
The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure.
excitation of vasomotor center by aortic body chemoreceptor signalling
The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure.
excitation of vasomotor center by carotid body chemoreceptor signalling
A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.
vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure
A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.
vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure
The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs.
blood pressure regulation by stress relaxation
The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine.
blood pressure regulation by epinephrine
regulation of blood pressure by adrenaline
The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine.
blood pressure regulation by norepinephrine
regulation of blood pressure by noradrenaline
The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment.
blood pressure regulation by capillary fluid shift
The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide.
blood pressure regulation by ANP
blood pressure regulation by atrial natriuretic peptide
The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst.
angiotensin mediated drinking behavior
The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours.
master pacemaker clock regulation of blood pressure
SCN regulation of blood pressure
The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours.
circadian regulation of heart contraction rate by the suprachiasmatic nucleus
master pacemaker clock regulation of heart rate
SCN regulation of heart rate
The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
hormonal cardiac inotropy
hormonal regulation of the force of heart muscle contraction
The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction.
decreased force of heart contraction by acetylcholine
The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
hormonal cardiac chronotropy
regulation of the rate of heart contraction by hormone
The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure.
vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system.
renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system
The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction.
increased force of heart contraction by epinephrine released from the nerve endings
increased force of heart contraction by neuronal adrenaline
increased force of heart contraction by neuronal epinephrine
positive regulation of heart contraction by adrenaline
positive regulation of heart contraction by neuronal epinephrine
The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction.
increased force of heart contraction by circulating adrenaline
increased force of heart contraction by epinephrine in the bloodstream
positive regulation of heart contraction by circulating adrenaline
positive regulation of heart contraction by circulating epinephrine
The process in which renal water excretion is decreased.
negative regulation of renal water excretion
The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system.
regulation of blood pressure by circulating adrenaline-noradrenaline
The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule.
angiotensin-mediated regulation of glomerular filtration
regulation of glomerular filtration by angiotensin
The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction.
increased force of heart contraction by circulating noradrenaline
increased force of heart contraction by circulating norepinephrine
The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction.
increased force of heart contraction by neuronal noradrenaline
increased force of heart contraction by neuronal norepinephrine
The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction.
positive regulation of heart rate by circulating adrenaline
The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction.
positive regulation of heart rate by neuronal adrenaline
The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction.
positive regulation of heart rate by neuronal noradrenaline
The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction.
positive regulation of heart rate by circulating noradrenaline
Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream.
regulation of vasoconstriction by circulating noradrenaline
Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings.
regulation of vasoconstriction by neuronal noradrenaline
Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings.
regulation of vasoconstriction by neuronal adrenaline
Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream.
regulation of vasoconstriction by circulating adrenaline
A vasodilation process resulting from secretion of epinephrine into the bloodstream or released by nerve endings.
regulation of vasodilation by adrenaline
regulation of vasodilation by circulating adrenaline
regulation of vasodilation by circulating epinephrine
regulation of vasodilation by epinephrine
regulation of vasodilation by neuronal adrenaline
regulation of vasodilation by neuronal epinephrine
A vasodilation process resulting from secretion of norepinephrine into the bloodstream or released by nerve endings.
regulation of vasodilation by circulating noradrenaline
regulation of vasodilation by circulating norepinephrine
regulation of vasodilation by neuronal noradrenaline
regulation of vasodilation by neuronal norepinephrine
regulation of vasodilation by noradrenaline
regulation of vasodilation by norepinephrine
Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction.
mesodermal-endodermal cell signalling involved in heart induction
Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction.
endodermal-mesodermal cell signalling involved in heart induction
The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
FHS specification
first heart field specification
The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
anterior heart field specification
second heart field specification
SHF specification
The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field.
cardiac crescent morphogenesis
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers.
AV bundle cell differentiation
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.
cardiac Purkinje fiber cell differentiation
The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
SA valve formation
The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart.
embryonic cardiac muscle physiological hypertrophy
The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart.
myocardial progenitor cell midline convergence
Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle.
regulation of FHF cardioblast proliferation
regulation of first heart field cardiac proliferation
regulation of first heart field cardioblast proliferation
The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
Notch signaling pathway involved in regulation of second heart field cardioblast proliferation
Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation
The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation
hh signaling pathway involved in regulation of second heart field cardioblast proliferation
smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation
smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation
smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation
Any apoptotic process that contributes to the shaping of a heart valve.
apoptosis involved in heart valve morphogenesis
Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
apoptosis involved in endocardial cushion morphogenesis
The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction.
cell proliferation involved in atrial ventricular junction remodelling
cell proliferation involved in atrio-ventricular junction remodeling
cell proliferation involved in atrio-ventricular junction remodelling
cell proliferation involved in atrioventricular junction remodeling
cell proliferation involved in atrioventricular junction remodelling
Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction.
apoptosis involved in atrial ventricular junction remodelling
apoptosis involved in atrio-ventricular junction remodeling
apoptosis involved in atrio-ventricular junction remodelling
apoptosis involved in atrioventricular junction remodeling
apoptosis involved in atrioventricular junction remodelling
Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
negative regulation of Wnt receptor signaling pathway involved in heart development
negative regulation of Wnt receptor signalling pathway involved in heart development
negative regulation of Wnt-activated signaling pathway involved in heart development
The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment.
myocardial progenitor epithelial polarization
The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment.
cardiac progenitor cell midline fusion
The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
pancreatic alpha cell development
The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin.
pancreatic delta cell development
The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
pancreatic B cell fate commitment
The delamination process that results in the shedding of a corneocyte from the surface of the epidermis.
epidermal desquamation
The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
norepinephrine secreting neuron development
A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
S1P receptor signaling pathway
S1P signaling pathway
S1P-activated G-protein coupled receptor signaling pathway
S1P-activated GPCR signaling pathway
S1P-stimulated signal transduction pathway
sphingolipid signaling pathway
sphingolipid signalling pathway
The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells.
RPE development
The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure.
optic cup structural organisation
The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth.
growth plate cartilage axis determination
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell.
regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway
Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins.
AT binding
AT DNA binding
AT-rich DNA binding
Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
ARS binding
Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis.
DNA clamp loading ATPase activity
DNA-protein loading ATPase activity
PCNA loading activity
PCNA loading complex activity
protein-DNA loading ATPase activity
A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases.
transcription elongation regulator activity
transcriptional elongation regulator activity
Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.
double-stranded RNA specific editase activity