NothingMuch/GO-Terms huggingface dataset:
Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway.
positive regulation of NOD1 signaling pathway
positive regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.
negative regulation of NOD2 signaling pathway
negative regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway
Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.
positive regulation of NOD2 signaling pathway
positive regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway
A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway.
Shc-Egfr complex, EGF stimulated
A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway.
Grb2-Egfr complex, EGF stimulated
A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway.
Grb2-Shc complex, EGF stimulated
A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein.
G protein complex (BTK, GNG1, GNG2)
G protein complex (Btk, Gng2, Gnb1)
An integrin complex that comprises one alphaIIb subunit and one beta3 subunit.
alphaIIb-beta3 integrin complex
ITGA2B-ITGB3 complex
Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation.
negative regulation of oligodendrocyte precursor proliferation
Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation.
positive regulation of oligodendrocyte precursor proliferation
Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin.
CrCOMT2
flavonoid 3\',5\'-O-dimethyltransferase activity
S-adenosyl-L-methionine:myricetin O-methyltransferase activity
A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits.
elongin (SIII) complex
transcription elongation factor SIII complex
transcription factor B (SIII) complex
A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule.
IL4-IL4 receptor complex
IL4-IL4R-IL2RG complex
A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located.
imaginal disc-derived wing hair
non-sensory hair
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.
activation of ergosterol biosynthetic process
positive regulation of ergosterol anabolism
positive regulation of ergosterol biosynthesis
positive regulation of ergosterol formation
positive regulation of ergosterol synthesis
stimulation of ergosterol biosynthetic process
up regulation of ergosterol biosynthetic process
up-regulation of ergosterol biosynthetic process
upregulation of ergosterol biosynthetic process
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.
down regulation of heme biosynthetic process
down-regulation of heme biosynthetic process
downregulation of heme biosynthetic process
inhibition of heme biosynthetic process
negative regulation of haem biosynthetic process
negative regulation of heme anabolism
negative regulation of heme biosynthesis
negative regulation of heme formation
negative regulation of heme synthesis
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.
activation of heme biosynthetic process
positive regulation of haem biosynthetic process
positive regulation of heme anabolism
positive regulation of heme biosynthesis
positive regulation of heme formation
positive regulation of heme synthesis
stimulation of heme biosynthetic process
up regulation of heme biosynthetic process
up-regulation of heme biosynthetic process
upregulation of heme biosynthetic process
Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.
cellular detoxification of nitrogenous compound
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate.
tubulin-activated ATPase activity
A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.
ITGA1-ITGB1-COL6A3 complex
A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.
ITGA2-ITGB1-COL6A3 complex
A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA.
DNA recombination complex RC-1
RC-1 complex (recombination complex 1)
The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentin.
dentin secretion
dentine secretion
predentin secretion
Any process that decreases the frequency, rate or extent of uterine smooth muscle contraction.
down regulation of uterine smooth muscle contraction
down-regulation of uterine smooth muscle contraction
downregulation of uterine smooth muscle contraction
inhibition of uterine smooth muscle contraction
negative regulation of myometrial contraction
negative regulation of myometrial smooth muscle contraction
negative regulation of myometrium contraction
uterine smooth muscle relaxation
Any process that increases the frequency, rate or extent of uterine smooth muscle contraction.
activation of uterine smooth muscle contraction
positive regulation of myometrial contraction
positive regulation of myometrial smooth muscle contraction
positive regulation of myometrium contraction
stimulation of uterine smooth muscle contraction
up regulation of uterine smooth muscle contraction
up-regulation of uterine smooth muscle contraction
upregulation of uterine smooth muscle contraction
The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
3\'-5\' NMD
3\'-5\' nonsense-mediated decay
3\'-5\' nonsense-mediated mRNA decay
nuclear-transcribed mRNA breakdown, 3\'-5\' exonucleolytic nonsense-mediated decay
nuclear-transcribed mRNA catabolism, 3\'-5\' exonucleolytic nonsense-mediated decay
nuclear-transcribed mRNA degradation, 3\'-5\' exonucleolytic nonsense-mediated decay
The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction.
5\'-3\' NMD
5\'-3\' nonsense-mediated decay
5\'-3\' nonsense-mediated mRNA decay
nuclear-transcribed mRNA breakdown, 5\'-3\' exonucleolytic nonsense-mediated decay
nuclear-transcribed mRNA catabolism, 5\'-3\' exonucleolytic nonsense-mediated decay
nuclear-transcribed mRNA degradation, 5\'-3\' exonucleolytic nonsense-mediated decay
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon.
non-stop decay
non-stop mRNA decay
nonstop mRNA decay
nuclear-transcribed mRNA breakdown, non-stop decay
nuclear-transcribed mRNA catabolism, non-stop decay
nuclear-transcribed mRNA degradation, non-stop decay
The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one.
dehydro-D-arabinono-1,4-lactone anabolism
dehydro-D-arabinono-1,4-lactone biosynthesis
dehydro-D-arabinono-1,4-lactone formation
dehydro-D-arabinono-1,4-lactone synthesis
The process in which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of Pup and the epsilon-amino group of a lysine residue of the target protein.
Pup-protein conjugation
pupylation
Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
negative regulation of thrombin receptor signaling pathway
negative regulation of thrombin receptor signalling pathway
Any process that activates or increases the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
positive regulation of thrombin receptor signaling pathway
positive regulation of thrombin receptor signalling pathway
A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore.
exosporium formation
The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds, that forms all or part of a bacterial capsule.
capsular poly-gamma-glutamate biosynthetic process
capsule poly-gamma-glutamate anabolism
capsule poly-gamma-glutamate biosynthesis
capsule poly-gamma-glutamate formation
capsule poly-gamma-glutamate synthesis
The chemical reactions and pathways resulting in the formation of a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments.
selenium-containing prosthetic group anabolism
selenium-containing prosthetic group biosynthesis
selenium-containing prosthetic group formation
selenium-containing prosthetic group synthesis
A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma.
pollenkitt
tryphine
Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis.
HDL receptor
high-density lipoprotein receptor activity
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin.
ITGA2b-ITGB3-TLN1 complex
A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2.
cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex
A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37.
RFC core complex
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family.
ITGA4-ITGB1-CD53 complex
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family.
ITGA4-ITGB1-CD63 complex
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family.
ITGA4-ITGB1-CD81 complex
A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae.
Rad1-Rad10 complex
XPF-ERCC1 complex
An siRNA-mediated post-transcriptional gene silencing pathway that blocks the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically mediate repression of translation if the siRNA perfectly complements elements located in the 3' untranslated region of target mRNAs.
down regulation of translation involved in RNA interference
down-regulation of translation involved in RNA interference
downregulation of translation involved in RNA interference
inhibition of translation involved in RNA interference
negative regulation of translation involved in RNA interference
RNA interference, negative regulation of translation
The process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase.
rDNA condensation
rDNA packaging
Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters.
argonaute endoribonuclease activity
Combining with nicotinic acid to initiate a change in cell activity.
niacin receptor activity
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof).
SNARE complex (Stx3, Snap25, Vamp2, Cplx1)
Stx3-Snap25-Vamp2-Cplx1 complex
A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4.
TFIID complex, B-cell specific
A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family.
ITGAM-ITGB2-CD63 complex
A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism.
GALNS-lysosomal hydrolase 1.27 MDa complex
Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity.
down regulation of vitamin D receptor signaling pathway
down-regulation of vitamin D receptor signaling pathway
downregulation of vitamin D receptor signaling pathway
inhibition of vitamin D receptor signaling pathway
negative regulation of VDR signaling pathway
negative regulation of VDR signalling pathway
negative regulation vitamin D receptor signalling pathway
Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity.
activation of vitamin D receptor signaling pathway
positive regulation of VDR signaling pathway
positive regulation of vitamin D receptor signalling pathway
stimulation of vitamin D receptor signaling pathway
up regulation of vitamin D receptor signaling pathway
up-regulation of vitamin D receptor signaling pathway
upregulation of vitamin D receptor signaling pathway
Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
metallo-exo-dipeptidase activity
metalloexodipeptidase activity
The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of pheromone-induced unidirectional conjugation.
peptide mating pheromone formation involved in pheromone-induced unidirectional conjugation
peptide mating pheromone processing involved in pheromone-induced unidirectional conjugation
Binding to a histone in which a lysine residue has been modified by acetylation.
acetylated histone residue binding
A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
microRNA loading complex
miRLC
RLC
Catalysis of the reaction: 5-methylcytosine (5mC) in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine (5hmC) in DNA + succinate + CO2. This reaction is the first step in the removal of cytosine methylated on position 5 in double-stranded DNA. This activity can iteratively oxidize 5hmC to 5-formylcytosine (5fC) and to 5-carboxylcytosine (5caC).
methylcytosine dioxygenase activity
The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J.
base J metabolism
beta-D-glucosyl-HOMedU metabolic process
beta-D-glucosyl-hydroxymethyluracil metabolism
A DNA-dependent DNA replication process in which a single-stranded DNA molecule is synthesized from a circular duplex template. Replication typically does not cease when one circumference has been replicated, but continues around the circumference several more times, producing a long single strand comprising multimers of the replicon.
rolling circle replication
A DNA-dependent DNA replication process in which a double-stranded DNA molecule is synthesized from a circular duplex template.
theta replication
The process in which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore.
ascospore-type prospore membrane bending
forespore membrane bending
FSM bending
The process in which dendrites recognize and avoid contact with sister dendrites from the same cell.
dendrite repulsion
Binding to a juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone.
JHRE binding
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores.
regulation of fungal type cell wall 1,3-alpha-glucan biosynthetic process
regulation of fungal-type cell wall 1,3-alpha-glucan anabolism
regulation of fungal-type cell wall 1,3-alpha-glucan biosynthesis
regulation of fungal-type cell wall 1,3-alpha-glucan formation
regulation of fungal-type cell wall 1,3-alpha-glucan synthesis
regulation of fungal-type cell wall alpha-1,3-glucan anabolism
regulation of fungal-type cell wall alpha-1,3-glucan biosynthesis
regulation of fungal-type cell wall alpha-1,3-glucan biosynthetic process
regulation of fungal-type cell wall alpha-1,3-glucan formation
regulation of fungal-type cell wall alpha-1,3-glucan synthesis
Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to the arginine residue at position 2 of histone H3.
histone H3R2 arginine methyltransferase activity
histone methylase activity (H3-R2 specific)
histone methyltransferase activity (H3-R2 specific)
histone-arginine N-methyltransferase activity (H3-R2 specific)
histone-H3R2 methyltransferase activity
Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H2A.
histone H2AR3 arginine methyltransferase activity
histone methylase activity (H2A-R3 specific)
histone methyltransferase activity (H2A-R3 specific)
histone-arginine N-methyltransferase activity (H2A-R3 specific)
histone-H2AR3 methyltransferase activity
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate.
down regulation of thiamine diphosphate biosynthetic process
down-regulation of thiamine diphosphate biosynthetic process
downregulation of thiamine diphosphate biosynthetic process
inhibition of thiamine diphosphate biosynthetic process
negative regulation of thiamin diphosphate biosynthetic process
negative regulation of thiamine diphosphate anabolism
negative regulation of thiamine diphosphate biosynthesis
negative regulation of thiamine diphosphate formation
negative regulation of thiamine diphosphate synthesis
A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
Grb2-mSos1 complex
A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
Shc-Grb2-mSos1 complex, EGF stimulated
A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
Egfr-Grb2-mSos1 complex, EGF stimulated
A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits.
N-acetylglucosamine-1-phosphotransferase complex
UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase complex
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine.
down regulation of thiamine biosynthetic process
down-regulation of thiamine biosynthetic process
downregulation of thiamine biosynthetic process
inhibition of thiamine biosynthetic process
negative regulation of thiamin biosynthetic process
negative regulation of thiamine anabolism
negative regulation of thiamine biosynthesis
negative regulation of thiamine formation
negative regulation of thiamine synthesis
Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity
adenylosuccinase activity
adenylosuccinate lyase activity
SAICAR-lyase (fumarate forming) activity
succino AMP-lyase activity