NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + O2 = a very-long-chain (2E)-enoyl-CoA + H2O2.
very long chain fatty-acyl-CoA oxidase activity
very-long-chain acyl-CoA oxidase activity
VLC fatty-acyl-CoA oxidase activity
The chemical reactions and pathways performed by an organism resulting in the proteolytic processing of an inactive enzyme to an active form in another organism.
zymogen activation in other organism
A process in which a symbiont initiates, promotes, or enhances the normal activation of plasminogen, the pathway resulting in the processing of inactive plasminogen to active plasmin in the host organism. This can facilitate the dissemination of the symbiont into host tissues. It can also be used to destroy complement, opsonins as well as antibacterial proteins like histones.
plasminogen activation in another organism
plasminogen activation in other organism
The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of plasminogen into plasmin in the bitten organism. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
envenomation resulting in plasminogen activation in other organism
A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1.
non-specific lethal complex
Binding to a DNA topoisomerase.
DNA topoisomerase I binding
Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS.
S100 alpha binding
S100 beta binding
S100 binding
Binding to a GTP cyclohydrolase.
GTP cyclohydrolase I binding
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant vasodilation of blood vessels, usually causing a reduction in blood pressure, in the bitten/stung organism.
envenomation resulting in modulation of vasodilation in other organism
envenomation resulting in regulation of vasodilation in other organism
envenomation resulting in vasodilation in other organism
A process by which an organism causes vasodilation of blood vessels, usually causing a reduction in blood pressure, in another organism.
modulation of vasodilation in other organism
regulation of vasodilation in other organism
vasodilation in other organism
Any process that stops, prevents or reduces the frequency of heart contraction of another organism.
negative regulation of heart rate in other organism
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of the heart rate of the bitten/stung organism.
envenomation resulting in negative regulation of heart rate of other organism
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant slowing of the activation kinetics of the activity of a voltage-gated potassium channel in the bitten/stung organism.
envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in other organism
voltage-dependence of activation shift (to the left)
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant blocking of a voltage-gated potassium channel, inhibiting the pore's activity, in the bitten/stung organism.
envenomation resulting in occlusion of the pore of voltage-gated potassium channel in other organism
A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant primary cell wall. In Arabidopsis, contains the essential component proteins CESA1 and -3, and a CESA6-related protein.
primary cell wall CESA complex
primary cell-wall cellulose synthase complex
A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant secondary cell wall. In Arabidopsis, contains the essential component proteins CESA8, CESA7, and CESA4.
secondary cell wall CESA complex
secondary cell-wall cellulose synthase complex
A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer.
Ni-Fe hydrogenase complex
nickel-iron hydrogenase complex
A bacterial cell envelope-associated multiprotein system, which binds and degrades starch.
Sus complex
The biochemical reactions and pathways resulting in the formation of a P-cluster of a nitrogenase, a high-nuclearity, Fe/S-only cluster that can be viewed as two  sub-clusters sharing a gamma-6-sulfide.
nitrogenase P cluster biosynthesis
nitrogenase P cluster maturation
Binding to iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase.
FeMo co binding
FeMoco binding
An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo.
adaptor protein-5 adaptor complex
The removal of an adenylyl group (adenosine 5'-monophosphate; AMP) from a protein amino acid.
protein deAMPylation
Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins.
protein deAMPylase activity
protein deAMPylation activity
Enables the directed movement of a phytochelatin from one side of a membrane to the other. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes.
ABC-type phytochelatin transmembrane transporter activity
ATP-dependent phytochelatin transmembrane transporter activity
ATPase-coupled phytochelatin transmembrane transporter activity
cadystin transmembrane transporter activity
cadystin transmembrane transporter ATPase activity
cadystin transporter activity
phytochelatin transmembrane transporter activity
phytochelatin transmembrane transporter ATPase activity
phytochelatin transporter activity
Enables the directed movement of flavine mononucleotide (FMN) from one side of a membrane to the other.
flavine mononucleotide transmembrane transporter activity
A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex.
Nup170 complex
A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p).
Nic96 complex
Nup82 complex
The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.
karyopherin docking complex
nuclear pore central channel
nuclear pore central plug
nuclear pore transport channel
Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component.
cytoplasmic fibers of the NPC
cytoplasmic fibers of the nuclear pore complex
The process in which an organism increases the extent of relaxation of smooth muscle in the uterus of a second organism.
positive regulation of relaxation of uterine smooth muscle in other organism
An occluding cell-cell junction formed between the membranes of the apical end of an invading cell (e.g. a merozoite in Plasmodium) and a host target cell (e.g. erythrocyte for Plasmodium infection). The junction is a stable yet dynamic structure that moves around the symbiont cell during invasion, enclosing it in a vacuole surrounded by a membrane.
host-parasite tight junction
host-pathogen tight junction
Any process that increases the pH of the phagosome, measured by the concentration of the hydrogen ion, as part of the process of phagosome maturation.
phagosomal reneutralization
phagosome pH elevation
Any process that modulates the volume of a post-lysosomal vacuole, a membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis.
regulation of post-lysosome size
regulation of postlysosomal vacuole size
regulation of postlysosome vacuole size
The disruption of host plasma membrane integrity by formation of a pore, resulting in deregulated ion homeostasis, and cellular dysfunction that can result in cell death.
pore formation in host plasma membrane
pore formation in membrane of host by symbiont
The dissemination of mature viral particles from a host cell via the formation by the virus of pores in its host cell membrane.
cytolysis by virus via pore formation in host cell membrane
viral exit by cytolysis via pore formation in host cell membrane
viral release by cytolysis via pore formation in host cell membrane
A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species.
Trr/COMPASS-like complex
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out).
(R)-carnitine:gamma-butyrobetaine antiporter activity
L-carnitine:4-(trimethylammonio)butanoate antiporter activity
L-carnitine:gamma-butyrobetaine antiporter activity
A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis.
carbon monoxide dehydrogenase
carbon-monoxide:(acceptor) oxidoreductase complex
CO dehydrogenase complex
CO dehydrogenase/acetyl-CoA synthase complex
CODH
CODH/ACS complex
A heterodimer which catalyses the reaction of 5-amino-6-(D-ribitylamino)uracil and 4-hydroxyphenylpyruvate to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), an intermediate of coenzyme F420.
FO-synthase complex
A protein complex consisted of eight polypeptides. This complex catalyzes the formation of methyl-coenzyme M and H4MPT from N5-methyl-H4MPT and CoM during methanogenesis.
5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethane sulfonate 2-methyltransferase complex
coenzyme M methyltransferase complex
methyl-H4MPT
N5-methyltetrahydromethanopterin-coenzyme M methyltransferase complex
A protein complex that in Methanobacterium thermoautotrophicum is composed of six subunits, and in Methanosarcina barkeri contains is composed of either two subunits or nine subunits. Catalyzes the conversion of coenzyme B, coenzyme M, and methanophenazine to form N-{7-heptanoyl}-3-O-phospho-L-threonine and dihydromethanophenazine.
coenzyme M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase complex
hydrogen:coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide oxidoreductase complex
A protein complex of two polypeptides which catalyzes the transfer of methyl group from methylthiol to coenzyme M during methanogenesis.
methylthiol coenzyme M methyl transferase complex
methylthiol:coenzyme M methyl transferase complex
methylthiol:CoM methyltransferase complex
Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+.
archaeal-specific GTP cyclohydrolase activity
Fe(2+)-dependent archaeal-specific GTP cyclohydrolase activity
MptA activity
Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM.
methylthiol:coenzyme M methyl transferase activity
Catalysis of the reaction: 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H+ + L-methionine + NH4+.
FO synthase
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in).
trehalose:hydrogen symporter activity
Entry of a symbiont's genome into a host cell by a pore formed by the symbiont in the host cell. Examples of this process include injection by a non-enveloped virus of the viral genome into the host cytoplasm, usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail.
membrane puncture-mediated penetration of viral genome into host cell
pore-mediated entry of viral genome into host cell
pore-mediated penetration of viral genome into host cell
viral entry via genome injection
viral genome delivery via icosahedral vertex
viral genome translocation
viral pore-forming protein
The process by which a virus causes the death of daughter cells which do not contain its genes after host cell division, by a mechanism of post-segregational killing (PSK). The extrachromosomal viral DNA consist of two genes; the product of the second is long lived and toxic, while the product of the first is short lived and antagonizes the lethal action of the toxin. Daughter cells that do not contain the viral extrachromosomal element are killed by the long lived toxin, while daughter cells that do contain the viral extrachromosomal element are protected by the action of the short lived antitoxin it encodes.
killing by virus of host cell by PSK
killing by virus of host cell by toxin-antitoxin system
The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore.
siderophore membrane transport
The global programming of epigenetic modifications in the female pronucleus of the newly fertilized zygote. The maternal genome is protected from global DNA demethylation before the first division of the zygote, and instead undergoes passive, replication-dependent demethylation during early embryogenesis, arising from inhibition of the DNA maintenance methyltransferase Dnmt1.
maintenance of DNA methylation at imprinted genes
protection of DNA demethylation of female pronucleus
protection of DNA methylation in female pronucleus
The global programming of epigenetic modifications in the male pronucleus of the newly fertilized zygote. The most major change in the paternal genome is DNA demethylation, which takes place before the first cell division.
DNA demethylation of male pronucleus
epigenetic reprograming of male pronucleus
epigenetic reprograming of paternal genome in zygote
Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
double-stranded hemi-methylated DNA binding
Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin.
bone sialoprotein II binding
A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity.
(Ost)2 complex
Ost alpha-Ost beta complex
SLC51 complex
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant positive regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism.
envenomation resulting in positive regulation of acid-sensing ion channel activity in other organism
envenomation resulting in positive regulation of ASIC channel activity in other organism
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism.
envenomation resulting in negative regulation of acid-sensing ion channel activity in other organism
envenomation resulting in negative regulation of ASIC channel activity in other organism
Any process in which an organism negatively regulates the activity of a voltage-gated sodium channel in another organism.
negative regulation of acid-sensing ion channel in other organism
negative regulation of ASIC channel in other organism
Any process in which an organism positively regulates the activity of a voltage-gated sodium channel in another organism.
positive regulation of acid-sensing ion channel in other organism
positive regulation of ASIC channel in other organism
A process that negatively regulates the sensory perception of pain in a different organism.
inhibition of sensory perception of pain in another organism
negative regulation of sensory perception of pain in other organism
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the sensory perception of pain in the bitten organism.
envenomation resulting in inhibition of sensory perception of pain in other organism
envenomation resulting in negative regulation of sensory perception of pain in other organism
Any process involved in forming distinct miRNA isoforms from a mature miRNA that differ at their 3'-ends.
mature miRNA 3\'-end processing
miRNA 3\' end terminal trimming
miRNA 3\'-end processing
miRNA trimming
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA.
exonucleolytic trimming to generate 3\' end of miRNA
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus.
cellular response to human chorionic gonadotrophin stimulus
A process in which a symbiont inhibits or disrupts the normal execution of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism.
negative regulation by symbiont of host synaptic transmission
A process in which a symbiont alters or subverts cholinergic synaptic transmission, the communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism.
modulation by symbiont of host cholinergic synaptic transmission
regulation by symbiont of host cholinergic synaptic transmission
A process in which a symbiont inhibits or disrupts the normal execution of cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism.
negative regulation by symbiont of host cholinergic synaptic transmission
A process in which a symbiont inhibits or disrupts the regulated release of a neurotransmitter from a cell in its host organism.
negative regulation by symbiont of host neurotransmitter secretion
A homotetrameric protein complex that is essential for DNA replication. It supercoils the single-stranded DNA preventing DNA duplexing before the polymerase holoenzyme passes and synthesizes the complementary strand. It is also involved in DNA recombination and repair.
SSB complex
A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells.
down regulation of release of virus from host
down regulation of viral exit
down regulation of viral release
down regulation of viral release from host cell
down regulation of viral shedding
down-regulation of release of virus from host
down-regulation of viral exit
down-regulation of viral release
down-regulation of viral release from host cell
down-regulation of viral shedding
downregulation of release of virus from host
downregulation of viral exit
downregulation of viral release
downregulation of viral release from host cell
downregulation of viral shedding
inhibition of release of virus from host
inhibition of viral exit
inhibition of viral release
inhibition of viral release from host cell
inhibition of viral shedding
negative regulation by host of viral release from host cell
negative regulation of release of virus from host
negative regulation of viral exit
negative regulation of viral release
negative regulation of viral release from host cell
negative regulation of viral shedding
A heterotrimeric protein complex with iron-sulfur and molybdenum cofactors that functions as a terminal reductase in electron transport pathways that operate during anaerobic nitrate respiration. In E. coli electrons are passed from the FdnGHI complex to the NarGHI complex via menoquinone and menaquinol. Within NarGHI, electrons are passed from the two heme molecules in the NarI subunit down a Fe-S cluster chain in the NarH and NarG subunits to the Molybdenum cofactor, Mo-bisMGD, in the NarG subunit.
cytoplasmic membrane-bound quinol-nitrate oxidoreductase
nitrate reductase A
The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
MIF production
The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
OSM production
The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
CCL17 production
TARC production
thymus and activation regulated chemokine production
The fermentation of organic substances with a net release of hydrogen.
carbohydrate fermentation
The production of hydrogen which results from the dissociation by light of water into molecular hydrogen and oxygen. This process is observed in cyanobacteria and microalgae.
hydrogen biosynthesis via biophotolysis
The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls.
3\' processing reaction
3\'-processing activity
The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses.
viral genome integration
A process in which a host organism modulates the frequency, rate or extent of viral RNA genome replication.
regulation by host of viral RNA genome replication