NothingMuch/GO-Terms huggingface dataset:
Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.
regulation of frizzled signaling pathway
regulation of frizzled signalling pathway
regulation of Wnt receptor signaling pathway
regulation of Wnt receptor signalling pathway
regulation of Wnt-activated signaling pathway
A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes.
clathrin cage
Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa).
clathrin adaptor
A clathrin coat found on an endocytic vesicle.
clathrin coat of endocytotic vesicle
A clathrin coat found on a vesicle of the trans-Golgi network.
clathrin coat of TGN vesicle
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
constitutive secretory pathway transport vesicle
Golgi to vacuole transport vesicle
Golgi-vacuole transport vesicle
secretory vesicle
A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport).
COPII vesicle
COPII-associated ER to Golgi transport vesicle
COPII-associated vesicle
COPII-coated vesicle
endoplasmic reticulum to Golgi transport vesicle
endoplasmic reticulum-Golgi transport vesicle
ER to Golgi constitutive secretory pathway transport vesicle
ER to Golgi transport vesicle
ER-Golgi transport vesicle
A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.
coatomer
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
endocytotic transport vesicle
endocytotic vesicle
A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.
TGN transport vesicle
trans-Golgi network constitutive secretory pathway transport vesicle
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
secretory vesicle
A vesicle that mediates transport from the Golgi to the endoplasmic reticulum.
Golgi to endoplasmic reticulum transport vesicle
Golgi to ER constitutive secretory pathway transport vesicle
Golgi-endoplasmic reticulum transport vesicle
Golgi-ER transport vesicle
retrograde transport vesicle
A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack).
inter-Golgi transport constitutive secretory pathway transport vesicle
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
sphingolipid anabolism
sphingolipid biosynthesis
sphingolipid formation
sphingolipid synthesis
The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
sphingolipid breakdown
sphingolipid catabolism
sphingolipid degradation
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
cell adhesion receptor regulator activity
The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex.
receptor signaling complex adaptor activity
receptor signaling complex scaffold activity
receptor signaling complex scaffold protein activity
receptor signalling complex adaptor activity
receptor signalling complex scaffold activity
Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
regulation of peptidolysis
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
cellular protein breakdown
cellular protein catabolic process
cellular protein catabolism
cellular protein degradation
multicellular organismal protein catabolic process
pheromone catabolic process
pheromone catabolism
protein breakdown
protein catabolism
protein degradation
The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
proteoglycan anabolism
proteoglycan biosynthesis
proteoglycan formation
proteoglycan synthesis
The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
proteoglycan breakdown
proteoglycan catabolism
proteoglycan degradation
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
blood coagulation, platelet activation
Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.
DNA replication licencing
DNA replication licensing
regulation of DNA replication initiation
regulation of DNA-dependent DNA replication initiation
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
activation of frizzled signaling pathway
activation of Wnt receptor signaling pathway
positive regulation of frizzled signaling pathway
positive regulation of frizzled signalling pathway
positive regulation of Wnt receptor signaling pathway
positive regulation of Wnt receptor signalling pathway
positive regulation of Wnt-activated signaling pathway
stimulation of frizzled signaling pathway
stimulation of Wnt receptor signaling pathway
up regulation of frizzled signaling pathway
up regulation of Wnt receptor signaling pathway
up-regulation of frizzled signaling pathway
up-regulation of Wnt receptor signaling pathway
upregulation of frizzled signaling pathway
upregulation of Wnt receptor signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
down regulation of frizzled signaling pathway
down regulation of Wnt receptor signaling pathway
down-regulation of frizzled signaling pathway
down-regulation of Wnt receptor signaling pathway
downregulation of frizzled signaling pathway
downregulation of Wnt receptor signaling pathway
inhibition of frizzled signaling pathway
inhibition of Wnt receptor signaling pathway
negative regulation of frizzled signaling pathway
negative regulation of frizzled signalling pathway
negative regulation of Wnt receptor signaling pathway
negative regulation of Wnt receptor signalling pathway
negative regulation of Wnt-activated signaling pathway
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
B cell development
B lymphocyte differentiation
B-cell differentiation
B-lymphocyte differentiation
The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine).
melatonin metabolism
Any process that activates or increases the frequency, rate or extent of blood coagulation.
activation of blood coagulation
stimulation of blood coagulation
up regulation of blood coagulation
up-regulation of blood coagulation
upregulation of blood coagulation
Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.
down regulation of blood coagulation
down-regulation of blood coagulation
downregulation of blood coagulation
inhibition of blood coagulation
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
extracellular matrix organisation
extracellular matrix organization and biogenesis
Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.
collagen fibril organisation
fibrillar collagen organization
The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.
heparan sulfate proteoglycan metabolism
heparan sulphate proteoglycan metabolic process
heparan sulphate proteoglycan metabolism
heparin proteoglycan metabolic process
The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
heparan sulfate metabolic process
heparin metabolism
The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.
glycosaminoglycan metabolism
The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
chondroitin sulfate metabolism
chondroitin sulphate metabolic process
chondroitin sulphate metabolism
The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues.
chondroitin sulfate B metabolic process
chondroitin sulfate B metabolism
dermatan sulfate metabolism
dermatan sulphate metabolic process
dermatan sulphate metabolism
The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
hyaluronan metabolism
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
hyaluronan anabolism
hyaluronan biosynthesis
hyaluronan formation
hyaluronan synthesis
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
keratinocyte cell differentiation
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
T cell development
T lymphocyte differentiation
T-cell differentiation
T-lymphocyte differentiation
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
erythrocyte cell differentiation
erythropoiesis
RBC differentiation
red blood cell differentiation
The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.
megakaryocyte cell differentiation
The process in which platelets bud from long processes extended by megakaryocytes.
platelet extrusion  systematic_synonym
The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell.
basophil cell differentiation
The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil.
eosinophil cell development
eosinophil cell differentiation
eosinophil development
The process in which a myeloid precursor cell acquires the specialized features of a neutrophil.
neutrophil cell differentiation
neutrophil granulocyte differentiation
neutrophil granulocytopoiesis
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.
monocyte cell differentiation
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
macrophage cell differentiation
Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
lipoprotein receptor activity
plasma lipoprotein particle receptor activity
Binds to and modulates the activity of an enzyme.
catalytic regulator activity
enzyme modulator
metalloenzyme regulator activity
Binds to and modulates the activity of nitric oxide synthase.
nitric oxide synthase regulator activity
The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions.
peroxisome degradation
peroxisome disassembly
pexophagy
The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
cellulose metabolism
The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
cellulose anabolism
cellulose biosynthesis
cellulose formation
cellulose synthesis
The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
cellulose breakdown
cellulose catabolism
cellulose degradation
Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
selectin
sugar binding
Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
polysaccharide assembly with MHC class II protein complex
Binds to and increases the activity of guanylate cyclase.
guanylin
The regulated release of growth hormone from secretory granules into the blood.
somatotropin secretion
The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
DNA condensation
eukaryotic chromosome condensation
nuclear chromosome condensation
Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.
apoptotic nuclear change
A phospholipase C-activating receptor G protein-coupled receptor signaling pathway that starts with an opsin being activated by a photon, and transmitting the signal through the Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). The second messengers, including cGMP, activate channels that result in transmission of the light signal  through the synapses. Typical examples are rhabdomeric photoreceptors in the eyes of protostomes.
phospholipase C-activating rhodopsin mediated G-protein coupled receptor signaling pathway
phospholipase C-activating rhodopsin mediated signaling pathway
PLC-activating rhodopsin mediated signaling pathway
rhodopsin mediated G protein signaling, coupled to IP3 second messenger
rhodopsin mediated G protein signalling, coupled to IP3 second messenger
rhodopsin mediated G-protein signaling, coupled to IP3 second messenger
rhodopsin mediated G-protein signalling, coupled to IP3 second messenger
Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
regulation of bone biosynthesis
regulation of bone formation
Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
down regulation of ossification
down-regulation of ossification
downregulation of ossification
inhibition of ossification
negative regulation of bone biosynthesis
negative regulation of bone formation
The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
bone calcification
Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+.
17beta-hydroxy steroid dehydrogenase
3(or 17)beta-hydroxysteroid dehydrogenase activity
3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
3beta-hydroxy steroid dehydrogenase
3beta-hydroxysteroid dehydrogenase
beta-hydroxy steroid dehydrogenase
Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
estrogen receptor activity
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
activation of cell growth
stimulation of cell growth
up regulation of cell growth
up-regulation of cell growth
upregulation of cell growth
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
down regulation of cell growth
down-regulation of cell growth
downregulation of cell growth
inhibition of cell growth
The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.
poly-N-acetyllactosamine metabolism
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
transverse tubule
triad
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
osteoclast cell differentiation
The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
flagellated sperm movement
sperm flagellum movement
sperm flagellum movement involved in flagellated sperm motility
sperm flagellum movement involved in flagellated sperm movement
sperm motility
sperm movement
The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.
melanocyte cell differentiation
melanophore differentiation
The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.
interrenal gland
The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.
prenylcysteine metabolism
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
DNA damage response, activation of p53
p53 signaling pathway
p53-mediated DNA damage response
TP53 signaling pathway
Any process that activates or increases the frequency, rate or extent of cell migration.
activation of cell migration
stimulation of cell migration
up regulation of cell migration
up-regulation of cell migration
upregulation of cell migration
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
down regulation of cell migration
down-regulation of cell migration
downregulation of cell migration
inhibition of cell migration
Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
IL-17 receptor activity
IL-17R
The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.
fructose 1,6-bisphosphate metabolism
The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.
fructosamine metabolism
The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.
fructosamine anabolism
fructosamine biosynthesis
fructosamine formation
fructosamine synthesis
The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.
fructosamine breakdown
fructosamine catabolism
fructosamine degradation
The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group.
fructoselysine metabolism
The controlled breakdown of any cell membrane in the context of a normal process such as autophagy.
membrane breakdown
membrane catabolism
membrane degradation