NothingMuch/GO-Terms huggingface dataset:
Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue.
E2
Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue.
E2
Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S = X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate.
E3
Catalysis of the transfer of FAT10 to a substrate protein via the reaction X-FAT10 + S = X + S-FAT10, where X is either an E2 or E3 enzyme, the X-FAT10 linkage is a thioester bond, and the S-FAT10 linkage is an isopeptide bond between the C-terminal glycine of FAT10 and the epsilon-amino group of lysine residues in the substrate.
E3
Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S = X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate.
E3
Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate.
E3
Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S = X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate.
E3
Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S = X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate.
E3
Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S = X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate.
E3
Neurotransmitter secretion that occurs in the presence of the action of a secretagogue or a presynaptic action potential.
stimulus-dependant neurotransmitter secretion
Enzyme complex that in S. cerevisiae has components Dug2/Dug3 and is able to catalyze the cleavage of glutathione into glutamate and Cys-Gly.
gamma-glutamyltranspeptidase complex
glutamine amidotransferase II complex
glutathionase complex
Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose.
rhamnose-binding lectin family protein binding
Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde.
2-keto-3-deoxygluconate aldolase activity
KDG aldolase activity
The process in which the branching structure of the seminal vesicle is generated and organized. A branch is a division or offshoot from a main stem.
gonecyst branching morphogenesis
seminal gland branching morphogenesis
seminal vesicle branching
seminal vesicle branching morphogenesis
Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 = hercynylcysteine sulfoxide + H2O.
hercynylcysteine S-oxide synthase
hercynylcysteine sulfoxide synthase
A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes.
gluconate pathway
Catalysis of the reaction: H2O + N(6)--L-lysyl- = (R)-lipoate + L-lysyl-.
lipoyl-X-hydrolase
A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins.
SEACAT complex
A protein complex that consists of an assemble of ASC dimers that is capable of inducing pyroptosis.
ASC pyroptosome
Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis.
folate receptor activity
The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and pyruvate.
sulfoglycolysis
A lysosomal membrane protein complex that enables the translocation of a target protein across the lysosomal membrane as part of chaperone-mediated autophagy.
chaperone-mediated autophagy receptor complex
CMA receptor complex
CMA translocation complex
Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in an acidic environment.
acid SMase
acid sphingomyelinase
Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in a neutral environment.
neutral SMase
neutral sphingomyelinase
Binding to long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats.
TERRA binding
The localization process by which an autophagic substrate is delivered to a forming autophagosome.
substrate sequestration to autophagosome
substrate sequestration to phagophore
Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor -> 2-oxoglutarate + reduced acceptor.
alpha-ketoglutarate reductase activity, reverse reaction
Catalysis of the reaction: 2-oxoglutarate + reduced acceptor -> (S)-2-hydroxyglutarate + acceptor.
2-hydroxyglutarate dehydrogenase activity, reverse reaction
2-ketoglutarate reductase activity
2-oxoglutarate reductase activity
D-2HG reductase activity
Binding to an alpha-latrotoxin receptor.
lasso receptor binding
latrophilin binding
The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle.
endosome-lysosome fusion
fusion of multivesicular body to lysosome
fusion of MVB to lysosome
late endosome-lysosome fusion
MVB-lysosome fusion
The process that increases the force with which blood travels through the lungs.
positive regulation of pulmonary blood pressure
The process that decreases the force with which blood travels through the lungs.
negative regulation of pulmonary blood pressure
The directed movement of a xenobiotic through the blood-nerve barrier.
drug transport across blood-nerve barrier
drug transport across perineurial barrier
A chromatin silencing complex that recruits histone-modifying enzymes and upregulates silencing of rDNA in response to glucose starvation.
energy dependent nucleolar silencing complex
Facilitating a conformational change to load a cohesin complex around sister chromatids.
cohesin loading activity
A DNA binding activity in which a protein complex interacts with at least one DNA duplex to encircle the DNA molecules with a loose fitting ring.
topological DNA entrapment activity
Fusion of the membrane of a transport vesicle with a target membrane on another vesicle.
vesicle to vesicle fusion
vesicle-vesicle fusion
A peptidoglycan endopeptidase activity that acts on a peptidoglycan cross-bridge.
lysostaphin activity
Binding to Epidermal Growth Factor (EGF) repeats.
Epidermal growth factor domain binding
Epidermal Growth Factor repeat binding
A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking.
dense core vesicle priming
large dense-core vesicle priming
LDCV priming
A chromatin silencing complex that binds and bridges separate nucleosomal histones resulting in heterochromatin assembly and chromatin looping.
nucleosome bridging complex
A laminin complex composed of alpha3B, beta3 and gamma2 polypeptide chains.
laminin 3B32 complex
Any process that activates or increases the frequency, rate or extent of DNA recombination at the centromere.
positive regulation of centromeric recombination
Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination at the centromere.
negative regulation of centromeric recombination
Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose, in a two steps reaction: first an ADP-ribosyl cyclase reaction, followed by a cyclic ADP-ribose hydrolase reaction.
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
NAD hydrolase
NAD(+) nucleosidase
NADase
nicotinamide adenine dinucleotide nucleosidase
Catalysis of the hydrolysis of ubiquitin units from Met1-linked (or linear) polyubiquitin chains.
cysteine-type deubiquitinase activity, acting on linear ubiquitin
deubiquitinase, acting on linear ubiquitin
linear ubiquitin specific deubiquitinase activity
Met1 linkage specific DUB
ubiquitinyl hydrolase activity, acting on linear ubiquitin
The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers.
ER-plasma membrane tethering
A telomere maintenance process that results in the formation of small fragments of circular extrachromosomal DNA elements which contain telomeric DNA. It is speculated that telomeric DNA-containing double minutes are formed through a recombination event between the telomere and chromosome-internal TTAGGG-like sequences. Telomeric DNA-containing double minutes appear as two closely positioned dots in metaphase.
TDMs formation
Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus.
telomeric Displacement-loop binding
An intracellular compartmentalized cilium structure found in insect spermatids which is bounded by a membrane derived from the invagination of the cell membrane that remains associated with the primary cilium as it is internalized. The ciliary cap is maintained at the end of the axoneme distal to the centriole and is separated from the cytosolic axoneme/cytoplasm by a putative transition zone, which may extend into the ciliary cap, and include a structure at the base of the ciliary cap termed the ring centriole.
spermatid ciliary cap
The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm.
intracellular ciliogenesis
Actin-based structures involved in establishing close contact between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell.
apical TBC
Actin-based structures involved in establishing the blood-testis barrier of the Sertoli cell.
basal TBC
Testis-specific junction between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell.
apical ES
Testis-specific junction between mature Sertoli cells involved in establishing the blood-testis barrier of the Sertoli cell.
basal ES
The part of an actin filament where the structure forks.
microfilament branch point
A macromolecular fiber consisting of actin and cofilin that is formed in the nucleus as a consequence of chemical or mechanical stress conditions.
intranuclear actin rod
Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high affinity ferrous uptake transmembrane transporter activity
high-affinity ferrous iron uptake transmembrane transporter activity
A protein complex which transports ferrous iron (Fe(III) or Fe3+) ions from the vacuole, the main storage component of intracellular free iron, into the cytoplasm in a low iron environment.
FET5-FTH1 high affinity iron exporter complex
FET5-FTH1 high-affinity iron exporter complex
high affinity iron exporter complex
The tissue remodeling process by which the Sertoli cell barrier is temporarily disrupted and reorganized to accommodate the transit of preleptotene spermatocytes at stage VIII of the epithelial cycle.
blood testis barrier restructuring
restructuring of blood-testis barrier
restructuring of BTB
restructuring of SCB
SCB remodeling
Sertoli cell barrier remodelling
Sertoli cell barrier restructuring
Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles.
ERV41-ERV46 retrograde receptor complex
retrograde receptor complex, Golgi to endoplasmic reticulum
retrograde receptor complex, Golgi to ER
retrograde transporter complex, Golgi to endoplasmic reticulum
The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome.
ER pQC
ER stress-indiced pre-emptive quality control
Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis.
DNA clamp unloading activity
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus.
cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one
cellular response to DIF-2
cellular response to DIF2
Any process that activates or increasesthe frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse.
positive regulation of anterograde axon transport of mitochondria
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse.
negative regulation of anterograde axon transport of mitochondria
A clathrin-mediated endocytosis process whereby yolk proteins are internalized and trafficked through the endocytic pathway for yolk deposition.
clathrin-dependent endocytosis involved in yolk formation
A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle.
isolation membrane
That part of the axonal growth cone which represents the distal part of the structure.
axonal growth cone leading edge
distal tip of axonal growth cone
That part of the dendritic growth cone which represents the distal part of the structure.
dendritic growth cone leading edge
distal tip of dendritic growth cone
Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (2S,3R,6S,9S)-(-)-protoillud-7-ene.
protoillud-7-ene synthase activity
Any process that reduces the frequency, rate or extent of the formation of radial glial scaffolds. The scaffolds are used as a substrate for the radial migration of cells.
negative regulation of Bergmann fiber biosynthesis
negative regulation of Bergmann fiber formation
negative regulation of radial glial scaffold formation
Any process that increases the frequency, rate or extent of the formation of radial glial cell scaffolds.
positive regulation of Bergmann fiber biosynthesis
positive regulation of Bergmann fiber formation
positive regulation of radial glial scaffold formation
A process in which a protein is transported to or maintained in a location within the somatodendritic compartment.
somatodendritic protein localization
Any process that stops, prevents or reduces the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents.
negative regulation of spontaneous acrosome loss
The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells.
cell separation during cytokinesis
cytokinetic abscission
The infiltration by sperm of the cumulus oophorus to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm.
penetration of cumulus cells layer
penetration of cumulus mass
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an (R)-carnitine stimulus.
response to L-carnitine
A protein complex that enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).
CAX1 homodimer
CAX1-CAX3 complex
CAX3 homodimer
An activity that displaces proteins or protein complexes from DNA, sometimes in a 'wire stripping' fashion, driven by ATP hydrolysis.
ATP-dependent protein-nucleic acid complex displacement activity
A protein complex that contributes to and regulates mitochondrial respiratory chain complex IV (COX) formation. It acts by regulating mitochondrial COX1 translation and by promoting the assembly of COX components.
COX pre-assemply complex
COX1 preassemply complex
The chemical reactions and pathways resulting in the formation of cichorine, a secondary metabolite found in some species of fungi.
cichorine anabolism
cichorine biosynthesis
cichorine formation
cichorine synthesis
The chemical reactions and pathways resulting in the formation of L-pipecolic acid, a metabolite of lysine.
L-pipecolate biosynthetic process
A homo- or heterotrimeric protein containing complex consisting of alpha and beta lymphotoxin subunits in different stoichiometric combinations.
lymphotoxin alpha-beta
A protein-containing complex composed of a stem-loop binding protein (in most species SLBP) and its interacting partner (SLIP1 or MIF4GD in most species) that binds to the histone mRNA (hmRNA) 3-prime-stem-loop structure. Facilitates hmRNA translation initiation and may also be involved in its processing and nuclear export.
SLBP-MIF4GD complex
SLBP-SLIP1 complex
Catalysis of the reaction: (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)- + 2 H+ + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)- + 2 H2O. Can also use a substrate with 3 double bonds (a (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA) and add a fourth double bond (a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA).
acyl-CoA (8-3)-desaturase
acyl-CoA D5-desaturase activity
acyl-CoA delta(5)-desaturase activity
A protein complex capable of catalysing the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+.
paaABCE complex
Binding to a TSC1-TSC2 complex.
tuberin sclerosis complex binding
tuberin-hamartin complex binding
A protein complex located in the chloroplast inner membrane and facing the stroma that is associated with the chloroplast inner membrane translocase complex and provides the ATPase motor activity to drive import of proteins into the chloroplast stroma.
TIC complex associated chloroplast protein import motor
Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2.
aspartate beta-hydroxylase activity
aspartyl/asparaginyl beta-hydroxylase activity
aspartylpeptide beta-dioxygenase activity
peptide-aspartate beta-dioxygenase activity
peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
Binding to a region of RNA containing a Pumilio-response element element. The consensus sequence for the element is UGUAAAUA.
PRE binding
The chemical reactions and pathways resulting in the formation of a fatty acid primary amide.
FAPA biosynthesis
FAPA biosynthetic process
fatty acid amide biosynthesis
The volume enclosed by the membrane of an early phagosome.
early phagocytic vesicle lumen
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 37) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 37). This reaction is the addition of a methyl group to the lysine residue at position 37 of the histone H3 protein.
histone H3K37 methylase activity
histone lysine N-methyltransferase activity (H3-K37 specific)
histone methyltransferase activity (H3-K37 specific)
histone-H3K37 methyltransferase activity
Combining with 4-hydroxybutyrte to initiate a change in cell activity.
gamma-hydroxybutyrate receptor activity
The chemical reactions and pathways resulting in the breakdown of primary fatty amides.
primary fatty amide catabolic process
A heterodimer involved in the stabilization of DNA recombination intermediates, the promotion of crossover recombination, and the proper assembly of the synaptonemal complex in meiotic prophase nuclei. In yeast the complex consists of two subunits, Msh4 and Msh5.
Msh4-Msh5 complex
Any constituent part of a chitin-based noncellular, hardened, or membranous extracellular matrix secreted from the apical surface of an epithelial sheet.
chitin-based ECM
A extracellular matrix which attaches an organism to a substrate.
puparial glue
Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O.
But-3-enyl Glucosinolate-2-hydroxylase activity
A plasma membrane protein complex capable of low-density lipoprotein particle receptor activity. It may also bind xenobiotic toxins and deliver them into the cell via endocytosis. While most substrates get degraded via the endosome the receptor is recycled to the plasma membrane. It may also act as a transducer of intracellular signal pathways and often acts in corporation with other cell-surface receptors.
LDL receptor complex
LDLR complex
low-density lipoprotein particle receptor complex
A septin collar in pathogenic fungi involved in the constriction of hyphae at the plant plasmodesma enabling penetration of an adjacent cell.
septin collar of invasive hyphae
A protein-containing complex that functions with the RNA exosome and contributes to the degradation of abberant transcripts.
NEXT complex
Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H+ + S-adenosyl-L-homocysteine.
mRNA (cytosine-5-)-methyltransferase activity
A protein adaptor that recognizes and binds an RNA molecule modified by C5-methylcytidine.
C5-methylcytidine-containing RNA binding
C5-methylcytosine-containing RNA binding
Catalysis of the reaction: H+ + H2O + N6-methyl-AMP = IMP + methylamine. Can also use N6-methyl-dAMP as a substrate.
MAPDA
N6-mAMP deaminase activity
N6-methyl-AMP/dAMP aminohydrolase
Enables the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane.
mitochondrial potassium channel activity
mitoK-ATP activity
Any process that increases the frequency, rate or extent of a pyocyanine biosynthetic process.
positive regulation of pyocyanin biosynthetic process