NothingMuch/GO-Terms huggingface dataset:
Oxidation of Fe(3+) to Fe(2+) on the outer side of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction.
ascorbate-cytochrome b5 reductase activity
L-ascorbate-cytochrome-b5 reductase activity
L-ascorbate:ferricytochrome-b5 oxidoreductase activity
A complex comprised of DNA wound around a multisubunit core and associated proteins containing the histone H3, which forms the primary packing unit of DNA into higher order structures.
histone H3 containing nucleosome
Any process involved in the maintenance of an internal steady state of ascorbate at the level of a cell.
cellular ascorbate homeostasis
The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy.
mitophagy receptor
An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by extracellular cAMP binding to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process.
extracellular cAMP signaling pathway
A DNA translocase activity that folds chromosomal DNA and catalytically extends the newly formed loop, driven by ATP hydrolysis.
chromatin extrusion activity
Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop.
enhancer-promoter loop anchoring activity
Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop.
terminator-promoter loop anchoring activity
Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to the arginine residue at position 8 of histone H3.
histone H3R8 arginine methylase activity
histone H3R8 arginine methyltransferase activity
histone methyltransferase activity (H3-R8 specific)
histone-H3R8 methyltransferase activity
The apoplast region surrounding a host plant cell. Plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. The host is defined as the larger of the organisms involved in a symbiotic interaction.
host cell apoplast
A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. MIM constitutes the major integration site for alpha-helical embedded proteins. In yeast, consists oof Mim1 and Mim2.
mitochondrial outer import machinery
A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. TOM transports beta-barrel precursors across the outer membrane and the sorting and assembly machinery (SAM complex) inserts them into the target membrane.
translocase of the outer mitochondrial membrane
Inclusion bodies located at the nucleolar periphery where several nuclear factors are reversibly aggregated and sequestered during acute heat stress or starvation.
nucleolar ring
NuRs
Binds to and increases the activity of a cysteine-type endopeptidase.
caspase activator activator activity
The chemical reactions or pathway resulting in the formation of phycocyanobilin, which involves the oxidative cleavage of heme by a heme oxygenase (HO) to form biliverdin IX alpha. Biliverdin IX alpha is subsequently converted to phycocyanobilin by a ferredoxin-dependent oxidoreductase (PCYA).
phycocyanobilin biosynthesis
The chemical reactions and pathways resulting in the formation of dihydroxy naphthalene (DHN)-melanin.
DHN-melanin biosynthesis
A protein complex that catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA.
citrate lyase complex
citrate synthase complex
Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates.
iodide peroxidase-tyrosine iodinase activity
iodotyrosine deiodase activity
monoiodotyrosine deiodinase activity
tyrosine iodinase activity
Catalysis of the reaction: 2 Fe3+-siderophore + NAD+ + H+ -> 2 Fe2+-siderophore + NADH.
ferric chelate reductase activity
iron chelate reductase activity
NADH:Fe(3+) oxidoreductase activity
NADH:Fe3+ oxidoreductase activity
A short filamentous structure on the surface of a bacterial cell distinguished from other pili by their D-mannose-sensitive agglutinatination of erythrocytes. In E. coli, type I pili consist of a short tip fibrillum made up of the adhesin protein (FimH) and two minor subunits (FimG and FimF) that is joined to the pilus rod, a homopolymer of ~1000 FimA subunits.
type 1 pilus
type I fimbriae
type I pili
The assembly from its constituent parts of a type I pilus.
T1P assembly
type 1 pilus biogenesis
type I fimbria assembly
type I fimbria biogenesis
type I fimbriae assembly
type I fimbriae biogenesis
type I fimbrial assembly
type I fimbrial biogenesis
type I fimbrium assembly
type I fimbrium biogenesis
Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes.
met-enkephalin receptor activity
metenkefalin receptor activity
methionine enkephalin receptor activity
The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.
DesCEND
Catalysis of the reaction: 2 geranylgeranyl diphosphate -> all-trans-phytoene + 2 diphosphate.
phytoene synthase activity
A small heterodimeric protein complex that is required during early maturation of nascent 40S ribosomal subunits. The complex has endonuclease activity, it interacts with the small ribosomal subunit pre-rRNA and cleave it it to produce the mature 18S (or small ribosomal subunit) rRNA. In S. cerevisiae it is composed of Rcl1p and Bms1p.
small ribosomal subunit maturation complex
Any process that increases the frequency, rate or extent of a pyroptotic inflammatory response.
positive regulation of pyroptosis
The spindle organization process in which the spindle is maintained at a constant length during mitotic metaphase.
metaphase spindle stability
metaphase spindle stabilization
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.
3-hydroxy-3-methylglutaryl coenzyme A reductase activity
beta-hydroxy-beta-methylglutaryl CoA-reductase activity
beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity
HMG-CoA reductase activity
hydroxymethylglutaryl coenzyme A reductase activity
Extracellular microbicidal structure composed of nuclear chromatin, histones and granular antimicrobial proteins. Histones and several neutrophil granule proteins associated with the DNA framework damage entrapped microorganisms.
NET
The aggregation, arrangement and bonding together of a set of components to form a neutrophil extracellular trap, a network of extracellular fibers primarily composed of DNA from neutrophils, which bind and neutralizes pathogens.
NET formation
A electron transport chain in which one or more electron carriers operate to transfer electrons from donors to a cytochrome P450 protein or domain. Electron carriers operating in this chain include FAD-containing flavoproteins or domains, FMN domains, ferredoxins and cytochrome b5. The reduced cytochrome P450 functions as the terminal oxidase and participates in a wide range of biochemical pathways.
P450-containing system
The directional movement of a hyphal filament from one host cell to another. This process involves the clearance of plant-derived plasmodesmal occlusion materials, cytoskeleton based constriction of invasive hypha to traverse plasmodesmata. Septins and F-actin are reorganized into an hourglass shape at the point of maximum hyphal constriction.
cell-to-cell migration by invasive hypha
host tissue colonization
invasive growth
invasive hyphae formation
plant tissue colonization
The chemical reactions and pathways resulting in the formation of pyripyropene A.
pyripyropene A anabolism
pyripyropene A biosynthesis
pyripyropene A formation
pyripyropene A synthesis
The chemical reactions and pathways resulting in the formation of tryprostatin A.
tryprostatin A anabolism
tryprostatin A biosynthesis
tryprostatin A formation
tryprostatin A synthesis
Binds to and increases the activity of a motor protein.
motor activity activator activity
Binds to and stops, prevents, or reduces the activity of a motor protein.
motor activity inhibitor activity
A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis.
ATP-dependent DNA damage sensing activity
A histone chaperone that carries a H3-H4 histone complex, driven by ATP hydrolysis.
ATP-dependent H3-H4 histone complex loader activity
H3-H4 dimer loading activity
H3-H4 histone chaperone
H3-H4 histone complex loader activity
histone chaperone
histone H3-H4 dimer loading activity
Facilitating a conformational change to unload a cohesin complex from sister chromatids.
cohesin unloading activity
A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and H2B. In budding yeast shares the histone acetylation (HAT) module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex.
ADA HAT complex
ADA histone acetyltransferase complex
Ada2/Gcn5/Ada3 transcription activator complex
scADA
A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation.
Ada two A containing complex
Ada Two-A containing complex
Ada-Two-A-containing complex
ADA2A-containing complex
G-ATAC complex
KAT2A-containing ATAC complex
KAT2B-containing ATAC complex
A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation.
chromatin maintenance during transcription elongation
co-transcriptional chromatin reassembly
DNA replication-independent chromatin organization
euchromatin maintenance during transcription elongation
maintenance of chromatin integrity during transcription elongation by RNAPII
maintenance of transcriptionally active chromatin during transcription elongation
transciptional elongation-coupled chromatin remodeling
transcription elongation coupled chromatin remodeling
transcriptional elongation-coupled chromatin remodeling
Fluctuation in the extracellular cAMP levels due to the alternate activation of adenylate cyclase, which produces cAMP, and phosphodiesterase, which degrades it. Occurs in Dictyostelium during early sorocarp development. Oscillation in signaling result is directional chemotaxis of cells towards the center of the aggregate.
cAMP relay
Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
histone H3-di/monomethyl-lysine-36 demethylase activity
histone H3K36me demethylase activity
histone H3K36me2 demethylase activity
Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
histone H3-tri/dimethyl-lysine-36 demethylase activity
histone H3K36me2 demethylase activity
histone H3K36me3 demethylase activity
Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction.
histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity
histone H3K4me demethylase activity
histone H3K4me2 demethylase activity
Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
histone H3-di/monomethyl-lysine-9 demethylase activity
histone H3K9me demethylase activity
histone H3K9me2 demethylase activity
Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
histone H3-tri/dimethyl-lysine-9 demethylase activity
histone H3K9me2 demethylase activity
histone H3K9me3 demethylase activity
Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction.
histone H3-di/monomethyl-lysine-9 FAD-dependent demethylase activity
histone H3K9me demethylase activity
histone H3K9me2 demethylase activity
Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate.
phase separation nucleation activity
phase separation nucleator activity
Catalysis of the reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol.
L-2-hydroxyglutarate dehydrogenase activity
The process in which physical connections are formed between sub-telomeric heterochromatin and the nuclear envelope facilitating bouquet formation.
attachment of telomeres to nuclear envelope
attachment of telomeric chromatin to nuclear envelope
heterochromatin organization
Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(2'-5') (cyclic 3',2' GAMP).
3\',2\' cyclic-GMP-AMP synthase activity
3\',2\'-cyclic GAMP synthase activity
Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(3'-5') (cyclic 3',3' GAMP).
3\',3\' cyclic-GAMP synthase activity
3\',3\' cyclic-GMP-AMP synthase activity
3\',3\'-cyclic GAMP synthase activity
Binding to 3',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 3',5' linkages.
3\',3\' cyclic-GMP-AMP binding
3\',3\'-cGAMP binding
3\',3\'-cGMP-AMP binding
3\',3\'-cyclic GAMP binding
Binding to 3',2' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 2',5' linkages.
3\',2\' cyclic-GMP-AMP binding
3\',2\'-cGAMP binding
3\',2\'-cyclic GAMP binding
Any process that activates or increases the frequency, rate or extent of a Frizzled Nuclear Import pathway.
positive regulation of FNI
positive regulation of Frizzled Nuclear Import Wnt Pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of a Frizzled Nuclear Import pathway.
negative regulation of FNI
negative regulation of Frizzled Nuclear Import Wnt Pathway
The chemical reactions and pathways resulting in the formation of mycophenolic acid (MPA). MPA is the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893.
MPA anabolism
MPA biosynthesis
MPA formation
MPA synthesis
mycophenolic acid anabolism
mycophenolic acid biosynthesis
mycophenolic acid formation
mycophenolic acid synthesis
Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of patulin.
positive regulation of patulin anabolism
positive regulation of patulin formation
positive regulation of patulin synthesis
Any process that reduces or removes the toxicity of free heme. These include transport of heme away from sensitive areas and to compartments or complexes whose purpose is sequestration of heme.
free heme detoxification
The formation of pericentric heterochromatin by a process mediated by a small interfering RNA (siRNA).
RNAi-mediated heterochromatin assembly at centromere
siRNA dependent pericentric heterochromatin assembly
siRNA-dependent pericentric heterochromatin assembly
siRNA-dependent pericentric heterochromatin formation
Binding to a GC-box, a DNA motif with the consensus sequence GGGCGG that is located upstream of the start point of eukaryotic transcription units. The GC-box may occur in multiple copies or in either orientation relative to the transcription start site.
GC box binding
GC rich promoter region binding
GC-rich region binding
GC_rich_promoter_region binding
A process that reduces or removes the toxicity of an endogenously produced substance. Mechanisms of resistance to endogenously produced compounds include modification the compound, export, sequestration, or mutations in the target enzyme.
prevention of self-toxicity
self-resistance to bioactive secondary metabolite
self-resistance to endogenously produced compound
self-resistance to endogenously produced toxin
Any process that activates or increases the frequency, rate or extent of production of amphiregulin.
positive regulation of AREG production
The elimination of ammonium ions from an excretory cell.
ammonia excretion
Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of lovastin.
positive regulation of mevacor biosynthetic process
positive regulation of mevinolin biosynthetic process
positive regulation of monacolin K biosynthetic process
Intracellular non-membrane bound organelle, consisting of proteinaceous polyhedral shells that encapsulate enzymes, protecting the contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only one protein, and has only a few proteins inside. Shells about vary from about 25-42 nm in diameter. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla.
protein nanocompartment
Catalyzes the reaction: ATP + -S-sulfanyl-L-cysteine + uracil in tRNA + 2 reduced ferredoxin  cluster = AMP + diphosphate + 4-thiouracil in tRNA + -L-cysteine + 2 oxidized ferredoxin  cluster.
tRNA U4 sulfurtransferase
tRNA uracil 4 sulfurtransferase
tRNA uracil 4-sulfurtransferase
A histone octamer slider activity that spaces nucleosomes along chromosomal DNA. This activity is involved in assembling chromatin in uniform nucleosome arrays to regulate transcription by RNA polymerases I, II, and III, as well as DNA replication, recombination and repair.
nucleosome array spacing activity
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 56) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 56). This reaction is the addition of a methyl group to the lysine residue at position 56 of the histone H3 protein.
histone H3K56 methylase activity
histone lysine N-methyltransferase activity (H3-K56 specific)
histone methyltransferase activity (H3-K56 specific)
histone-H3K56 methyltransferase activity
Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 56 of the histone H3 protein.
histone demethylase activity (H3-K56 specific)
histone H3-tri/dimethyl-lysine-56 demethylase activity
histone H3K56me2 demethylase activity
histone H3K56me3 demethylase activity
Catalysis of the reactions: nucleoside 3',5'-cyclic AMP + H2O = AMP + H+; this activity is activated by binding to calcium-bound calmodulin.
calcium- and calmodulin-regulated 3\',5\'-cyclic-AMP phosphodiesterase activity
calcium- and calmodulin-regulated AMP-specific phosphodiesterase activity
calcium- and calmodulin-regulated cAMP phosphodiesterase activity
calcium- and calmodulin-regulated cyclic-AMP phosphodiesterase activity
calcium/calmodulin-regulated cAMP-specific phosphodiesterase activity
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 56) + NAD+ + H2O = histone H3 L-lysine (position 56) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K56 to NAD, producing nicotinamide.
NAD-dependent histone deacetylase activity (H3-K56 specific)
NAD-dependent histone H3-K56 deacetylase activity
NAD-dependent histone H3K56 deacetylase activity
Binding to an actin filament and promoting the dissociation of an actin filament branch.
actin debranching activity
The appearance of XCL1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
lymphotactin production
The chemical reactions and pathways resulting in the formation of ilicicolin H, a 4-hydroxy-2-pyridone alkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain.
ilicicolin H anabolism
ilicicolin H biosynthesis
ilicicolin H formation
ilicicolin H synthesis
The chemical reactions and pathways resulting in the formation of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety.
novofumigatonin anabolism
novofumigatonin biosynthesis
novofumigatonin formation
novofumigatonin synthesis
The chemical reactions and pathways resulting in the formation of (M)-viriditoxin, a fungal secondary metabolite with antibacterial activity.
(M)-viriditoxin anabolism
(M)-viriditoxin biosynthesis
(M)-viriditoxin formation
(M)-viriditoxin synthesis
viriditoxin anabolism
viriditoxin biosynthesis
viriditoxin formation
viriditoxin synthesis
Binding to and responding, e.g. by conformational change, to changes in the cellular level of glutamine.
glutamine sensing activity
Catalysis of the active transport of a L-glutamate across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.
glutamate uniporter activity
Catalysis of the reaction: histone H2AX serine phosphate (position 140) + H2O = histone H2AX serine (position 140) + phosphate.
histone H2-S140 serine phosphatase activity
histone H2S140 phosphatase activity
histone serine phosphatase activity (H2-S140 specific)
Catalysis of the reaction: histone H2AX tyrosine phosphate (position 142) + H2O = histone H2AX tyrosine (position 142) + phosphate.
histone H2-Y142 phosphatase activity
histone H2Y142 phosphatase activity
histone tyrosine phosphatase activity (H2-Y142 specific)
Catalysis of the reaction: H2O + histone H3 L-arginyl (position 2)= histone H3 L-citrullyl (position 2) + NH4+, resulting in histone H3 citrullination at position 2.
H3-R2 citrullination
histone H3-R2 arginine deiminase activity
histone-arginine deiminase activity (H3-R2 specific)
Catalysis of the reaction: H2O + histone H3 L-arginyl (position 8)= histone H3 L-citrullyl (position 8) + NH4+, resulting in histone H3 citrullination at position 8.
H3-R8 citrullination
histone H3-R8 arginine deiminase activity
histone-arginine deiminase activity (H3-R8 specific)