NothingMuch/GO-Terms huggingface dataset:
Binding to a prolactin-releasing peptide receptor.
prolactin-releasing peptide receptor ligand
Binding to a prostaglandin D2 receptor.
prostaglandin D2 receptor ligand
prostanoid DP receptor binding
Binding to an EP1 subtype prostaglandin E2 receptor.
EP1 subtype prostaglandin E2 receptor ligand
prostanoid EP1 receptor binding
Binding to an EP2 subtype prostaglandin E2 receptor.
EP2 subtype prostaglandin E2 receptor ligand
prostanoid EP2 receptor binding
Binding to an EP3 subtype prostaglandin E2 receptor.
EP3 subtype prostaglandin E2 receptor ligand
prostanoid EP3 receptor binding
Binding to an EP4 subtype prostaglandin E2 receptor.
EP4 subtype prostaglandin E2 receptor ligand
prostanoid EP4 receptor binding
Binding to a prostaglandin F2-alpha receptor.
prostaglandin F2-alpha receptor ligand
prostanoid FP receptor binding
Binding to a prostacyclin receptor.
prostacyclin receptor ligand
prostanoid IP receptor binding
Binding to a thromboxane A2 receptor.
prostanoid TP receptor binding
thromboxane A2 receptor ligand
Binding to a type 1 proteinase activated receptor.
thrombin receptor binding
type 1 proteinase activated receptor ligand
Binding to a type 2 proteinase activated receptor.
type 2 proteinase activated receptor ligand
Binding to a type 3 proteinase activated receptor.
type 3 proteinase activated receptor ligand
Binding to a type 4 proteinase activated receptor.
type 4 proteinase activated receptor ligand
Binding to a secretin receptor.
secretin receptor ligand
Binding to a type 1 somatostatin receptor.
type 1 somatostatin receptor ligand
Binding to a type 2 somatostatin receptor.
type 2 somatostatin receptor ligand
Binding to a type 3 somatostatin receptor.
type 3 somatostatin receptor ligand
Binding to a type 4 somatostatin receptor.
type 4 somatostatin receptor ligand
Binding to a type 5 somatostatin receptor.
type 5 somatostatin receptor ligand
Binding to a type 1 member 1 taste receptor.
type 1 member 1 taste receptor ligand
Binding to a type 1 member 2 taste receptor.
type 1 member 2 taste receptor ligand
Binding to a type 1 member 3 taste receptor.
sweet taste receptor binding
type 1 member 3 taste receptor ligand
The directed movement of a lipid droplet along a microtubule, mediated by motor proteins.
adiposome transport along microtubule
lipid body transport along microtubule
lipid particle transport along microtubule
Binding to a urotensin receptor.
urotensin receptor ligand
Binding to a type 1 vasoactive intestinal polypeptide receptor.
type 1 vasoactive intestinal polypeptide receptor ligand
type 2 PACAP receptor binding
Binding to a type 2 vasoactive intestinal polypeptide receptor.
type 2 vasoactive intestinal polypeptide receptor ligand
type 3 PACAP receptor binding
Binding to a V1A vasopressin receptor.
V1A vasopressin receptor ligand
Binding to a V1B vasopressin receptor.
V1B vasopressin receptor ligand
Binding to a V2 vasopressin receptor.
V2 vasopressin receptor ligand
The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane.
chloroplast inner membrane translocase complex
A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require.
down regulation of synaptic metaplasticity
down-regulation of synaptic metaplasticity
downregulation of synaptic metaplasticity
inhibition of synaptic metaplasticity
A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require.
activation of synaptic metaplasticity
stimulation of synaptic metaplasticity
up regulation of synaptic metaplasticity
up-regulation of synaptic metaplasticity
upregulation of synaptic metaplasticity
Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other.
vitamin B6 transporter activity
Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.
pyridoxal transporter activity
Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.
pyridoxine transporter activity
The series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function.
mitochondria-nucleus signal transduction
mitochondrial signaling pathway
mitochondrial signalling pathway
retrograde response
A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.
dTOR/dRaptor complex
dTORC1
mTORC1
nutrient sensitive complex
rapamycin and nutrient-sensitive TOR complex
TOR complex 1
TORC 1 complex
TORC1
A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.
mTORC2
rapamycin and nutrient-insensitive TOR complex
TOR complex 2
TORC 2 complex
TORC2
A two-stranded helical polymer of the protein actin.
F-actin
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.
down regulation of glucocorticoid catabolic process
down-regulation of glucocorticoid catabolic process
downregulation of glucocorticoid catabolic process
inhibition of glucocorticoid catabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.
activation of glucocorticoid catabolic process
stimulation of glucocorticoid catabolic process
up regulation of glucocorticoid catabolic process
up-regulation of glucocorticoid catabolic process
upregulation of glucocorticoid catabolic process
Catalysis of the reaction: a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.
very-long-chain fatty acid activation
very-long-chain fatty acid-CoA ligase activity
very-long-chain-fatty-acid-CoA ligase activity
A nuclear receptor-mediated signaling pathway initiated by a mineralocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
intracellular mineralocorticoid receptor signaling pathway
mineralocorticoid receptor signaling pathway
mineralocorticoid receptor signalling pathway
Binding to a nuclear cortisol receptor.
cortisol receptor binding
Binding to a nuclear mineralocorticoid receptor.
mineralocorticoid receptor binding
Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function.
cortisol receptor activity
Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine.
carcinine hydrolase activity
The region between the inner and outer lipid bilayers of a chloroplast envelope.
chloroplast envelope lumen
The region between the inner and outer lipid bilayers of a chromoplast envelope.
chromoplast envelope lumen
The volume enclosed by a plasma membrane-derived thylakoid.
plasma membrane thylakoid lumen
A G protein-coupled receptor signaling pathway initiated by a bombesin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
bombesin receptor signalling pathway
Binding to insulin-like growth factor I.
IGF-I binding
Binding to insulin-like growth factor II.
IGF-II binding
Binding to a thioesterase.
thiolesterase binding
Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan.
1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity
1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity
D-glucosyltransferase
oligoglucan-branching glycosyltransferase activity
T-enzyme
A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1).
IL-28 receptor complex
Binding to an interleukin-28 receptor.
IL-28
interleukin-28 receptor ligand
Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction.
down regulation of ARF protein signal transduction
down-regulation of ARF protein signal transduction
downregulation of ARF protein signal transduction
inhibition of ARF protein signal transduction
Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction.
activation of ARF protein signal transduction
stimulation of ARF protein signal transduction
up regulation of ARF protein signal transduction
up-regulation of ARF protein signal transduction
upregulation of ARF protein signal transduction
Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+.
2-methylbutanal reductase (NADP) activity
2-methylbutanol:NADP oxidoreductase activity
2-methylbutyraldehyde reductase (NADP) activity
A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material.
Balbiani body
mitochondrial aggregate
A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing.
negative elongation factor complex
The proteolytic processing of trypsinogen to the active form, trypsin.
cleavage of trypsinogen to trypsin
A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
small subunit processome
SSU processome
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + NAD+ + H2O = histone H3 L-lysine (position 14) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K14 to NAD, producing nicotinamide.
NAD-dependent histone deacetylase activity (H3-K14 specific)
NAD-dependent histone H3-K14 deacetylase activity
NAD-dependent histone H3K14 deacetylase activity
The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA.
mitochondrial DNA breakdown
mitochondrial DNA catabolism
mitochondrial DNA degradation
mtDNA breakdown
mtDNA catabolic process
mtDNA catabolism
mtDNA degradation
A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex
DRB sensitivity inducing factor complex
Spt4-Spt5 complex
Spt5-Spt4 complex
A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole.
micropexophagic apparatus
MIPA
A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria.
crypton
The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
diphosphatidylglycerol biosynthesis
diphosphatidylglycerol biosynthetic process
A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
plasma membrane bleb
Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
down regulation of translation initiation in response to osmotic stress
down-regulation of translation initiation in response to osmotic stress
downregulation of translation initiation in response to osmotic stress
inhibition of translation initiation in response to osmotic stress
Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
activation of translation initiation in response to osmotic stress
stimulation of translation initiation in response to osmotic stress
up regulation of translation initiation in response to osmotic stress
up-regulation of translation initiation in response to osmotic stress
upregulation of translation initiation in response to osmotic stress
Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated).
type IV restriction enzyme activity
A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation.
type IV restriction enzyme complex
Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.
down regulation of restriction endodeoxyribonuclease activity
down-regulation of restriction endodeoxyribonuclease activity
downregulation of restriction endodeoxyribonuclease activity
inhibition of restriction endodeoxyribonuclease activity
restriction alleviation
restriction endodeoxyribonuclease inhibitor
restriction enzyme inhibitor
Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
activation of endodeoxyribonuclease activity
endodeoxyribonuclease activator
stimulation of endodeoxyribonuclease activity
up regulation of endodeoxyribonuclease activity
up-regulation of endodeoxyribonuclease activity
upregulation of endodeoxyribonuclease activity
Any process that modulates the frequency, rate or extent of a type I restriction endodeoxyribonuclease activity.
regulation of type I restriction endodeoxyribonuclease activity
type I restriction endodeoxyribonuclease regulator
type I restriction enzyme regulator
Any process that modulates the frequency, rate or extent of a type II restriction endodeoxyribonuclease activity.
regulation of type II restriction endodeoxyribonuclease activity
type II restriction endodeoxyribonuclease regulator
type II restriction enzyme regulator
Any process that modulates the frequency, rate or extent of a type III restriction endodeoxyribonuclease activity.
regulation of type III restriction endoribonuclease activity
type III restriction endodeoxyribonuclease regulator
type III restriction enzyme regulator
Any process that modulates the frequency, rate or extent of a type IV restriction endodeoxyribonuclease activity.
regulation of type IV restriction endodeoxyribonuclease activity
type IV restriction endodeoxyribonuclease regulator
type IV restriction enzyme regulator
Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain.
DAPIN domain binding
PAAD domain binding
Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes.
Sterile Alpha Motif domain binding
Any process that increases appetite.
activation of appetite
appetite stimulation
positive regulation of hunger
stimulation of appetite
up regulation of appetite
up-regulation of appetite
upregulation of appetite
Catalysis of the reaction: D-glucitol + NADP+ = L-sorbose + H+ + NADPH. The reaction may occur, to a minor extent, in the reverse direction.
D-glucitol:NADP+ oxidoreductase activity
Sou1p
An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement.
HAA
The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation.
attachment of telomeres to spindle pole body
attachment of telomeric chromatin to spindle pole body
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans.
oral apparatus morphogenesis
oral apparatus organisation
oral apparatus organization and biogenesis
stomatogenesis
Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm.
deep fibre
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the macronucleus.
macronuclear organization
macronuclear organization and biogenesis
macronucleus organisation
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the micronucleus.
micronuclear organization
micronuclear organization and biogenesis
micronucleus organisation
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.
histone deacetylase activity (H3-K9 specific)
histone H3-K9 deacetylase activity
histone H3K9 deacetylase activity
The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring.
medial membrane band formation
A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
chromosomal passenger complex
CPC
CPC complex
Binding to a double-stranded DNA region containing an A/C mispair.
A/C mispair binding
C/A mispair binding
cytosine/adenine mispair binding
Binding to a double-stranded DNA region containing a G/T mispair.
G/T mispair binding
T/G mispair binding
thymine/guanine mispair binding
A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity.
ABAT complex
GABA transaminase complex
GABA-T complex
Binding to succinate-semialdehyde dehydrogenase.
succinic semialdehyde dehydrogenase binding
Any process that initiates the activity of the inactive enzyme protein kinase B.
protein kinase B activation
A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis.
actomyosin ring
cytokinetic ring
meiotic contractile ring
A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum.
sterol-rich membrane band
Binding to a polymer of the small ubiquitin-like protein SUMO.
Smt3 polymer binding
Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck.
cellular bud neck septin ring organisation
Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities.
acrosin heavy chain binding
acrosin light chain binding
A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis.
post-lysosome
postlysosome
Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.
down regulation of telomere maintenance via recombination
down-regulation of telomere maintenance via recombination
downregulation of telomere maintenance via recombination
inhibition of telomere maintenance via recombination
Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.
activation of telomere maintenance via recombination
stimulation of telomere maintenance via recombination
up regulation of telomere maintenance via recombination
up-regulation of telomere maintenance via recombination
upregulation of telomere maintenance via recombination
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
down regulation of telomere maintenance via telomerase activity
down-regulation of telomere maintenance via telomerase activity
downregulation of telomere maintenance via telomerase activity
inhibition of telomere maintenance via telomerase
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
activation of telomere maintenance via telomerase
stimulation of telomere maintenance via telomerase
up regulation of telomere maintenance via telomerase activity
up-regulation of telomere maintenance via telomerase activity
upregulation of telomere maintenance via telomerase activity
Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA.
down regulation of telomere maintenance via semi-conservative replication
down-regulation of telomere maintenance via semi-conservative replication
downregulation of telomere maintenance via semi-conservative replication
inhibition of telomere maintenance via semi-conservative replication