NothingMuch/GO-Terms huggingface dataset:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
fructose PTS transporter activity
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
sucrose PTS transporter activity
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
trehalose PTS transporter activity
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
N-acetylglucosamine PTS transporter activity
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
N-acetylgalactosamine PTS transporter activity
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
beta-glucoside PTS transporter activity
Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive.
ionophore activity
Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.
low-affinity tryptophan permease activity
Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
IK calcium-activated potassium channel activity
IK KCa channels
intermediate conductance KCa channels
Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell.
nuclear migration to female gametophyte poles
nuclear migration to megagametophyte poles
nucleus migration to embryo sac poles
nucleus migration to female gametophyte poles
nucleus migration to megagametophyte poles
Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell.
nuclear migration to the embryo sac centre
nuclear migration to the female gametophyte center
nuclear migration to the female gametophyte centre
nuclear migration to the megagametophyte center
nuclear migration to the megagametophyte centre
nucleus migration to the female gametophyte center
nucleus migration to the female gametophyte centre
Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.
regulation of gene expression as a consequence of signal transmission
The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
positive adaptation of signalling pathway
A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell.
cellular potassium ion homeostasis
A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.
core extracellular matrix
core matrisome
A component of the extracellular matrix that enables the matrix to recoil after transient stretching.
core extracellular matrix
core matrisome
elastin
Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell.
microspike biogenesis
microspike biosynthesis
microspike formation
A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces.
epidermal attachment structure
fibrous organelle
hemi-adherens junction
trans-epithelial attachment
Catalysis of the reaction: an aralkylamine + H2O + 2 oxidized  = an aromatic aldehyde + 2 H+ + NH4+ + 2 reduced .
aralkylamine:(azurin) oxidoreductase (deaminating) activity
aromatic amine dehydrogenase (azurin) activity
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
(S)-malate:NAD+ oxidoreductase activity
L-malate-NAD+ oxidoreductase activity
malate (NAD) dehydrogenase activity
malic acid dehydrogenase activity
malic dehydrogenase activity
MDH
NAD-dependent malate dehydrogenase activity
NAD-dependent malic dehydrogenase activity
NAD-L-malate dehydrogenase activity
NAD-linked malate dehydrogenase activity
NAD-malate dehydrogenase activity
NAD-malic dehydrogenase activity
NAD-specific malate dehydrogenase activity
Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.
cristae
mitochondrial cristae
Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm.
LH1 complex
light harvesting complex I
Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex.
LH3 complex
light harvesting complex III
Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex.
LH2 complex
light harvesting complex II
A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species.
plasma membrane photosystem I
A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone.
plasma membrane photosystem II
A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors.
glial cell line-derived neurotrophic factor receptor binding
glial cell line-derived neurotrophic factor receptor ligand
A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).
AP-1 related adapter complex
HA1
HA1 clathrin adaptor
A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
HA2
HA2 clathrin adaptor
One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.
coatomer
Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors.
alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity
alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity
GnTV activity
N-acetylglucosaminyltransferase V activity
UDP-N-acetyl-D-glucosamine:6--glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity
UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity
UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity
uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity
uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity
Binding to a manganese ion (Mn).
manganese binding
Mn binding
The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.
mitochondrial matrix protein import
mitochondrial translocation
protein transport into mitochondrial matrix
Binding to a molybdenum ion (Mo).
Mo ion binding
molybdenum binding
The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.
bacteriocin anabolism
bacteriocin biosynthesis
bacteriocin formation
bacteriocin synthesis
Binding to a peripheral benzodiazepine receptor (PBR).
benzodiazepine receptor ligand
diazepam binding inhibitor activity
Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate.
peptide O-xylosyltransferase activity
UDP-D-xylose:core protein beta-D-xylosyltransferase activity
UDP-D-xylose:core protein xylosyltransferase activity
UDP-D-xylose:protein beta-D-xylosyltransferase activity
UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity
UDP-xylose-core protein beta-D-xylosyltransferase activity
uridine diphosphoxylose-core protein beta-xylosyltransferase activity
uridine diphosphoxylose-protein xylosyltransferase activity
The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule.
GKAP/Homer scaffold activity
GKAP/Homer scaffold protein
postsynaptic density scaffold protein
Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
DHR-domain binding
GLGF-domain binding
Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.
LDL binding
Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage gated proton channel activity
voltage-dependent proton channel activity
The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine).
melatonin anabolism
melatonin biosynthesis
melatonin formation
melatonin synthesis
Catalysis of the reaction: formamide = H2O + hydrogen cyanide.
formamide dehydratase activity
formamide hydro-lyase (cyanide-forming)
formamide hydro-lyase activity
Functions as a lubricant for an extracellular matrix, such as a mucous membrane.
core extracellular matrix
core matrisome
The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.
heparan sulfate proteoglycan breakdown
heparan sulfate proteoglycan catabolism
heparan sulfate proteoglycan degradation
heparan sulphate proteoglycan catabolic process
heparan sulphate proteoglycan catabolism
heparin proteoglycan catabolic process
The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
chondroitin sulfate anabolism
chondroitin sulfate biosynthesis
chondroitin sulfate formation
chondroitin sulfate synthesis
chondroitin sulphate biosynthesis
chondroitin sulphate biosynthetic process
The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
chondroitin sulfate breakdown
chondroitin sulfate catabolism
chondroitin sulfate degradation
chondroitin sulphate catabolic process
chondroitin sulphate catabolism
The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.
chondroitin sulfate B biosynthesis
chondroitin sulfate B biosynthetic process
dermatan sulfate anabolism
dermatan sulfate biosynthesis
dermatan sulfate formation
dermatan sulfate synthesis
dermatan sulphate biosynthesis
dermatan sulphate biosynthetic process
The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.
chondroitin sulfate B catabolic process
chondroitin sulfate B catabolism
dermatan sulfate breakdown
dermatan sulfate catabolism
dermatan sulfate degradation
dermatan sulphate catabolic process
dermatan sulphate catabolism
The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
heparan sulfate biosynthetic process
heparin anabolism
heparin biosynthesis
heparin formation
heparin synthesis
The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
heparan sulfate catabolic process
heparin breakdown
heparin catabolism
heparin degradation
The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
hyaluronan breakdown
hyaluronan catabolism
hyaluronan degradation
Binding to a semaphorin receptor.
plexin binding
plexin ligand
semaphorin receptor ligand
Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.
apolipoprotein E receptor activity
very-low-density lipoprotein receptor activity
VLDL receptor
Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription.
ICE activator complex
The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
protein secretion by the TOSS
protein secretion by the type I protein secretion system
type I protein secretion system
The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
protein secretion by the T3S
protein secretion by the T3SS
protein secretion by the TTSS
protein secretion by the type III protein secretion system
type III protein secretion system
The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system.
protein secretion by the T4SS
protein secretion by the type IV protein secretion system
type IV protein secretion system
A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space.
ABC translocator complex
A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase.
T3SS complex
TTSS complex
The compaction of chromatin during apoptosis.
pyknosis
The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.
apoptotic nuclear fragmentation
nuclear fragmentation during apoptosis
nucleus fragmentation
Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+.
quinate:NAD 3-oxidoreductase activity
quinate:NAD 5-oxidoreductase activity
quinate:NAD(+) 3-oxidoreductase activity
quinate:NAD(+) 5-oxidoreductase activity
quinic dehydrogenase activity
Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+.
glycolate:NADP+ oxidoreductase activity
glyoxylate reductase (NADP+)
NADPH-glyoxylate reductase activity
Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H+ = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420.
5,10-methylenetetrahydromethanopterin dehydrogenase activity
5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity
N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity
Catalysis of the reaction: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na+(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na+(out). 2-(methylthio)ethanesulfonate is also known as methyl-CoM.
5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity
N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity
N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity
tetrahydromethanopterin methyltransferase activity
Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H+ = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran.
formylmethanofuran-tetrahydromethanopterin formyltransferase activity
formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity
formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity
formylmethanofuran:tetrahydromethanopterin formyltransferase activity
FTR
N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity
Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H+ + phosphate.
5,10-methenyltetrahydrofolate synthetase activity
5-formyltetrahydrofolate cyclo-ligase (ADP-forming)
5-formyltetrahydrofolate cyclodehydrase
5-Formyltetrahydrofolate cyclodehydrase activity
formyltetrahydrofolic cyclodehydrase activity
methenyl-THF synthetase activity
Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity.
MCH receptor
The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure.
structural constituent of epidermis
The region between the plasma membrane and the cell wall in organisms lacking an outer cell membrane such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria.
cell wall bounded periplasmic space
cell wall-enclosed periplasmic space
inner wall zone
IWZ
The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
outer membrane bounded periplasmic space
outer membrane-enclosed periplasmic space
Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.
saposin