NothingMuch/GO-Terms huggingface dataset:
The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.
alkanesulfonate metabolism
alkanesulphonate metabolic process
alkanesulphonate metabolism
The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
choline metabolism
Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl- = CoA + S-hexadecanoyl-L-cysteinyl-.
protein-cysteine S-palmitoleyltransferase activity
The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
Mo-molybdopterin cofactor metabolism
Moco metabolic process
Moco metabolism
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
calcium ion signaling
calcium signaling
calcium signalling
calcium-mediated signalling
Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
B lymphocyte mediated immune effector process
B lymphocyte mediated immunity
B-cell mediated immune effector process
B-cell mediated immunity
B-lymphocyte mediated immune effector process
B-lymphocyte mediated immunity
The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings.
pentacyclic triterpenoid breakdown
pentacyclic triterpenoid catabolism
pentacyclic triterpenoid degradation
The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings.
pentacyclic triterpenoid metabolism
The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus.
hopanoid metabolism
The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings.
pentacyclic triterpenoid anabolism
pentacyclic triterpenoid biosynthesis
pentacyclic triterpenoid formation
pentacyclic triterpenoid synthesis
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids.
regulation of isoprenoid metabolism
The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.
secondary metabolism
secondary metabolite metabolic process
secondary metabolite metabolism
Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants.
chloroplast localisation
The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms.
polyhydric alcohol metabolic process
polyol metabolism
The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
carboxylic acid metabolism
The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
one carbon compound transport
The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits.
cyanogenic glycoside anabolism
cyanogenic glycoside biosynthesis
cyanogenic glycoside formation
cyanogenic glycoside synthesis
The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans.
glucosinolate metabolism
The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae.
glucosinolate anabolism
glucosinolate biosynthesis
glucosinolate formation
glucosinolate synthesis
The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae.
glucosinolate breakdown
glucosinolate catabolism
glucosinolate degradation
Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
FC receptor activity
Catalysis of the transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y = Y-FAT10 + X, where both X-FAT10 and Y-FAT10 are covalent linkages.
FAT10 conjugating enzyme activity
Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y = Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages.
APG12 conjugating enzyme activity
APG12 ligase activity
Atg12 conjugating enzyme activity
Atg12 ligase activity
An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins.
small conjugating protein-specific isopeptidase activity
small conjugating protein-specific protease activity
ubiquitin-like hydrolase activity
ubiquitin-like protein-specific isopeptidase activity
ubiquitin-like protein-specific protease activity
ubiquitin-like specific protease activity
ubiquitin-like-protein-specific protease activity
ubiquitin-specific protease activity involved in negative regulation of ERAD pathway
ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
ubiquitinyl-like hydrolase activity
An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.
NEDD8-specific protease activity
Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.
E2
E3
small conjugating protein ligase activity
small conjugating protein transferase activity
small protein conjugating enzyme activity
ubiquitin-like conjugating enzyme activity
ubiquitin-like-protein ligase activity
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
Hub1 conjugating enzyme activity
NEDD8 conjugating enzyme activity
RUB1 conjugating enzyme activity
Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages.
SMT3 conjugating enzyme
SUMO conjugating enzyme activity
The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.
quinolinate anabolism
quinolinate biosynthesis
quinolinate formation
quinolinate synthesis
A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
antibody
An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
antibody
B cell receptor accessory molecule complex
B lymphocyte receptor complex
B-cell receptor complex
B-lymphocyte receptor complex
BCR complex
immunoglobulin complex, membrane bound
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
maintenance of pluripotency
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).
ATP-dependent cation transmembrane transporter activity
ATPase-coupled cation transmembrane transporter activity
cation ABC transporter
cation-transporting ATPase activity
plasma membrane cation-transporting ATPase
The rupture of cell membranes and the loss of cytoplasm.
autolysin activity
bacteriocin activity
bacteriolytic toxin activity
holin
lysin activity
lysis
necrosis
Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
neurotrophin TRK receptor activity
Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation.
vitamin A1 alcohol binding
vitamin A1 binding
Binding to a ribosomal RNA.
base pairing with rRNA
The chemical reactions and pathways involving L-ascorbic acid, (2R)-2--4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
ascorbate metabolic process
ascorbate metabolism
L-ascorbic acid metabolism
vitamin C metabolic process
vitamin C metabolism
The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2--4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
ascorbate biosynthesis
ascorbate biosynthetic process
L-ascorbic acid anabolism
L-ascorbic acid biosynthesis
L-ascorbic acid formation
L-ascorbic acid synthesis
vitamin C biosynthesis
vitamin C biosynthetic process
The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
pyrimidine base anabolism
pyrimidine base biosynthesis
pyrimidine base biosynthetic process
pyrimidine base formation
pyrimidine base synthesis
The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.
cytosine metabolism
The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
thymine metabolism
The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.
uracil metabolism
The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway.
lysine anabolism via aminoadipic acid
lysine biosynthesis, aminoadipic acid pathway
lysine biosynthesis, aminoadipic pathway
lysine biosynthetic process, aminoadipic acid pathway
lysine biosynthetic process, aminoadipic pathway
lysine formation via aminoadipic acid
lysine synthesis via aminoadipic acid
The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
antigen presentation
antigen processing
The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex.
antigen presentation, endogenous antigen
The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex.
antigen presentation, exogenous antigen
The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
antigen presentation, endogenous peptide antigen
antigen processing, endogenous antigen via major histocompatibility complex class I
antigen processing, endogenous antigen via MHC class I
endogenous peptide antigen processing and presentation via MHC class I
Binds to and modulates the activity of a protein phosphatase.
calcineurin regulator activity
calcineurin, intrinsic regulator activity
protein phosphatase 2 regulator activity
protein phosphatase 2, intrinsic regulator activity
protein phosphatase 3 regulator activity
protein phosphatase 3, intrinsic regulator activity
protein phosphatase type 1 regulator activity
protein phosphatase type 1, intrinsic regulator activity
protein phosphatase type 2A regulator activity
protein phosphatase type 2A, intrinsic regulator activity
protein phosphatase type 2B regulator activity
protein phosphatase type 2B, intrinsic regulator activity
protein phosphatase type 4 regulator activity
protein phosphatase type 4, intrinsic regulator activity
The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group.
pteridine metabolism
The directed movement of mitochondria along microtubules in nerve cell axons.
axon transport of mitochondria
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic to plasma membrane
juxtamembrane
peripheral plasma membrane protein
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic to membrane
peripheral membrane protein
Binding to a specific domain of a protein.
protein domain-specific binding
Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
syntaxin-13 binding
syntaxin-2 binding
syntaxin-5 binding
syntaxin-6 binding
Cyclin-dependent protein kinase (CDK) complex found in the nucleus.
CDK holoenzyme
The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
lipid retention
lipid sequestering
lipid sequestration
retention of lipids
sequestering of lipids
sequestration of lipid
sequestration of lipids
storage of lipids
An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell.
3\',5\' cAMP-mediated signaling
3\',5\' cAMP-mediated signalling
3\',5\'-cAMP-mediated signaling
3\',5\'-cAMP-mediated signalling
adenosine 3\',5\'-cyclophosphate-mediated signaling
adenosine 3\',5\'-cyclophosphate-mediated signalling
cAMP signaling
cAMP signalling
cAMP-mediated signal transduction
cAMP-mediated signalling
cyclic AMP-mediated signaling
cyclic AMP-mediated signalling
An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell.
cGMP-mediated signalling
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.
modification-dependent protein breakdown
modification-dependent protein catabolism
modification-dependent protein degradation
modification-dependent proteolysis
modification-initiated protein catabolic process
modification-initiated protein catabolism
modification-initiated proteolysis
protein degradation tagging activity
protein-ligand-dependent protein catabolic process
protein-ligand-dependent protein catabolism
A type of reproduction in which new individuals are produced from a single organism, either from an unfertilized egg or from a single cell or group of cells.
parthenogenesis
Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
IL binding
interleukin binding
Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent.
IFN binding
Binding to interleukin-1.
IL-1 binding
Binding to interleukin-12.
IL-12 binding
Binding to a member of the interleukin-17 family of cytokines.
IL-17 binding
The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.
bypass DNA synthesis
The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine.
charged tRNA amino acid modification
charged tRNA modification
charged-tRNA modification
pre-translational amino acid modification
pre-translational protein modification
pretranslation protein modification
pretranslational amino acid modification
Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont.
bacterium-containing vacuole
parasitophorous vacuole
pathogen-occupied vacuole
Salmonella-containing vacuole
SCV
The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont.
parasitophorous vacuolar membrane
A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole.
paired organelles
toxoneme
A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell.
sarconeme
Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes.
cilial pocket
cilium pocket
flagellar pocket
An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations.
metachromatic granule
polyphosphate vacuole
volutin granule
Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell.
dense body
The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.
haemoglobin metabolic process
haemoglobin metabolism
hemoglobin metabolism
The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord.
spinal cord anterior-posterior patterning
spinal cord rostrocaudal patterning
The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord.
spinal cord dorsal-ventral patterning
spinal cord dorsoventral patterning
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate.
spinal cord dorsal interneuron differentiation
The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.
cerebrum development
The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis.
ventral thalamus development
The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
medulla development
myelencephalon development
The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
CN 1 development
cranial nerve 1 development
cranial nerve I development
The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.
CN II development
cranial nerve 2 development
cranial nerve II development
The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
isthmus morphogenesis
MHB morphogenesis