NothingMuch/GO-Terms huggingface dataset:
Binding a D-alanine and presenting it for processing or offloading to a cognate enzyme. Covalently binds the D-alanine via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into lipoteichoic acid by transferring activated D-alanine to cell membrane phosphatidylglycerol (PG).
D-alanyl carrier protein
A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.
protein localisation to T-tubule
protein localization to T tubule
protein localization to transverse tubule
The directed movement of an opsin (a G protein-coupled receptor of photoreceptor cells) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
ciliary transport of opsin
Catalysis of the reaction: alpha-L-fucose = beta-L-fucose.
alpha-L-fucose 1-epimerase activity
fucose 1-epimerase activity
type-2 mutarotase activity
Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate.
gamma-glutamyltranspeptidase activity
glutathionase activity
An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2.
Kbr, Ex and Mer complex
KEM complex
A form of mutualism between a fungus and the roots of a vascular plant, where hyphae of the fungus penetrate the plant cell wall and invaginate its cell membrane. Once inside, the fungus forms highly branched structures for nutrient exchange with the plant called arbuscules. Aids in the acquisition by the plant of nutrients such as phosphorus from the soil.
arbuscular mycorrhizae formation
arbuscular mycorrhizal symbiosis
arbuscular mycorrhizas formation
Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
1alpha,25(OH)2D3 biosynthesis
1alpha,25-dihydroxycholecalciferol biosynthesis
1alpha,25-dihydroxyvitamin D3 biosynthesis
calcitriol biosynthesis from calciol
vitamin D3 activation
Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol.
GlcNAc-P-P-Und synthase activity
UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase activity
UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity
UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-glucosaminephosphotransferase activity
UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity
Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate.
PdxST activity
pyridoxal 5\'-phosphate synthase (glutamine hydrolyzing) activity
Catalysis of the reaction: CDP + H2O = CMP + phosphate.
CDP diphosphatase activity
CDPase activity
cytidine diphosphatase activity
cytidine-diphosphatase activity
A process in which chromosomal DNA and associated proteins organize into a compact, orderly bacterial nucleoid. Often resulting in DNA supercoiling.
bacterial nucleoid DNA packaging
chromosomal compaction
nucleoid compaction
prokaryotic DNA condensation
A protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.
bacterial pre-RC
The aggregation, arrangement and bonding together of a set of components to form the bacterial pre-replicative complex, a protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.
bacterial pre-RC assembly
bacterial pre-replicative complex assembly
Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate.
lactoperoxidase activity
A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).
m(6)A writer complex
m6A methyltransferase complex
METTL3-METTL14-WTAP methyltransferase complex
MIS complex
Mum2, Ime4, and Slz1 complex
WMM complex
Catalysis of the reaction: formate + a quinone = CO2 + a quinol.
Fdh-N activity
formate dehydrogenase-N activity
formate:quinone oxidoreductase activity
A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology.
LAT signalosome
linker for activation of T cells signalosome
The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome.
LAT signalosome assembly
linker for activation of T cells signalosome assembly
Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide.
sNPF receptor activity
Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation.
PK receptor activity
Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.
ATPase involved in positive regulation of proteasomal protein catabolic process
proteasomal ATPase activity
proteasome channel gating activity
proteasome channel opening activity
proteasome-activating ATPase activity
Catalysis of the reaction: arachidonate + O2 = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate.
8(S)-lipoxygenase activity
8-lipoxygenase (S-type)
Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14).
histone acetylase activity (H3-K14 specific)
histone acetyltransferase activity (H3-K14 specific)
histone H3-K14 acetyltransferase activity
histone lysine N-acetyltransferase activity (H3-K14 specific)
A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6.
Mst2 complex
Mst2 H3K14 acetyltransferase complex
Mst2 histone H3K14 acetyltransferase complex
The component of mycolate membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.
extrinsic to external side of MOM
extrinsic to external side of mycolate outer membrane
extrinsic to external side of mycomembrane
Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate.
hexaprenyl diphosphate synthase activity
hexaprenyl pyrophosphate synthetase activity
Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid.
O-phosphoserine phosphohydrolase activity
phosphoserine phosphatase activity
Catalysis of the reaction: ATP + dCMP = ADP + dCDP.
ATP:dCMP phosphotransferase activity
Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+.
ditrans,polycis-undecaprenol kinase activity
A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina.
maintenance of ocular lens transparency
preservation of lens transparency
The self-renewing division of a neuronal stem cell.
NSC division
Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end.
uridylation-dependent decapping of nuclear-transcribed mRNA
Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor).
Fe-S transferase activity
Binding to a hepatocyte growth factor.
HGF binding
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope.
envelope stress response
Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death.
tumor necrosis factor-related apoptosis-inducing ligand receptor
Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin.
5-hydroxytryptophan decarboxylase activity
Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine.
4-dihydroxyl-L-phenylalanine decarboxylase activity
DDC activity
DOPA decarboxylase activity
Binds to and increases the activity of tyrosine 3-monooxygenase (tyrosine hydroxylase).
TH activator activity
tyrosine hydroxylase activator activity
Interacts with and increases L-dopa decarboxylase activity.
DDC activator activity
The movement of trunk neural crest cells from the neural tube, travelling dorso-laterally into the ectoderm and continuing toward the ventral midline of the belly. These migrating trunk neural crest cells become melanocytes, the melanin-forming pigment cells.
dorsolateral trunk NCC migration
The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta.
trunk NCC migration through anterior sclerotome
trunk NCC migration within somite
ventral trunk NCC migration
Binds to and stops, prevents or reduces the activity of nitric oxide synthase.
nitric oxide synthase inhibitor activity
NOS inhibitor activity
A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors.
CHOP-C/EBP dimer
CHOP-C/EBP heterodimer
GADD153-C/EBP complex
GADD153-C/EBP-alpha complex
The chemical reactions and pathways resulting in the formation of neuromelanin. Neuromelanin is a polymer of 5,6-dihydroxyindole monomers.
neuromelanin anabolism
neuromelanin biosynthesis
neuromelanin formation
neuromelanin synthesis
Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.
positive regulation of translation initiation in response to ER stress
Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.
negative regulation of translation initiation in response to ER stress
The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.
eIF2alpha dephosphorylation in response to ER stress
regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress
A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p.
Npl4p-Ufd1p complex
Ufd1-Npl4 binary complex
Ufd1-Npl4 cofactor complex
Ufd1/Npl4 complex
UFD1L-NPLOC4 complex
A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome.
Derlin-1/VIMP complex
The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane.
Golgi apparatus membrane fusion
membrane fusion involved in Golgi reassembly
post-mitotic fusion of Golgi membranes
Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D).
prosaposin-activated receptor activity
The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.
conversion of (Man)9(GlcNAc)2 to (Man)8C(GlcNAc)2
conversion of M9 to M8C
glycoprotein mannose trimming on C branch
A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel.
Derlin-1 complex
Derlin-1 protein dislocation complex
Derlin-1 retro-translocation complex
Derlin-1 retrotranslocon
ERAD protein dislocation complex
The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal.
chemoattraction of DA axon
chemoattraction of dopaminergic axon
The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal.
chemoattraction of 5-HT axon
chemoattraction of serotonergic axon
The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.
chemorepulsion of DA axon
chemorepulsion of dopaminergic axon
The process in which a serotonergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.
chemorepulsion of 5-HT axon
chemorepulsion of serotonergic axon
Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron.
astrocyte-dopaminergic neuron cell signaling
dopaminergic neuron-astrocyte crosstalk
mesencephalic dopaminergic neuron-astrocyte crosstalk
midbrain dopaminergic neuron-astrocyte crosstalk
A process in which a symbiont inhibits or disrupts the normal localization of a protein to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction.
disruption of host protein localisation to phagosome
inhibition of host protein localisation to phagosome
negative regulation by symbiont of host protein localization to phagocytic vesicle
suppression of host protein localisation to phagosome
Catalysis of the removal of a sugar or dicarbonyl from a glycated L-arginine, L-lysine or L-cysteine residue within proteins that have been attacked and modified by glyoxal or 2-oxopropanal.
glyoxylase III
protein deglycating enzyme
The removal of a sugar or dicarbonyl from a cysteine residue of a glycated protein.
deglycation of N-acetylcysteine
The removal of a sugar or dicarbonyl from an arginine residue of a glycated protein.
deglycation of N-acetylarginine
The removal of a sugar or dicarbonyl from a lysine residue of a glycated protein.
deglycation of N-acetyllysine
The removal of glyoxal from a glycated protein, to form glycolate and a deglycated protein.
protein deglycation of glyoxal-glycated protein
The removal of methylglyoxal from a glycated protein, to form lactate and a deglycated protein.
protein deglycation of methylglyoxal-glycated protein
The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other.
paracrine signalling
The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other.
endocrine signalling
Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor.
EGFR ligand maturation
EGFR ligand maturation by peptide bond cleavage
EGFR ligand processing
epidermal growth factor receptor ligand processing
peptide bond cleavage involved in EGFR ligand maturation
peptide bond cleavage involved in epidermal growth factor receptor ligand maturation
Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin.
attractive netrin receptor activity
netrin receptor activity involved in positive chemotaxis
Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation.
agonist-stimulated insulin receptor internalization
negative regulation of insulin receptor signalling pathway by insulin receptor internalization
Any process in which internalization of an insulin receptor activates or increases the frequency, rate or extent of the insulin receptor signaling pathway. Endocytosis of activated receptors can concentrate receptors within endosomes and allow the insulin receptor to phosphorylate substrates that are spatially distinct from those accessible at the plasma membrane.
positive regulation of insulin receptor signalling pathway by insulin receptor internalization
A receptor-mediated endocytosis process that results in the movement of a Wnt receptor from the plasma membrane to the inside of the cell.
Wnt receptor endocytosis
The chemical reactions and pathways resulting in the breakdown of a Wnt receptor. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.
Frizzled degradation
negative regulation of Wnt receptor signaling pathway by Wnt receptor degradation
Wnt receptor breakdown
Wnt receptor catabolism
Wnt receptor degradation
The process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.
Frizzled recycling
Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
G-protein coupled odorant receptor activity
G-protein coupled olfactory receptor activity
odorant receptor activity, G-protein coupled
olfactory receptor activity, G-protein coupled
Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
reeler receptor activity
The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
reeler-mediated signaling pathway
reelin-mediated signal transduction pathway
reelin-mediated signalling pathway
The signaling process in which G protein-coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal.
termination of G-protein coupled receptor signaling pathway
termination of G-protein coupled receptor signalling pathway
termination of GPCR signaling pathway
The series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signalling pathway
positive regulation of endothelial cell chemotaxis by VEGF/VEGFR signaling pathway
vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis
VEGF-mediated chemotactic endothelial cell migration
VEGF-VEGFR-induced endothelial cell chemotaxis
A G protein-coupled receptor signaling pathway in which the receptor constitutively activates adenylate cyclase, without binding to an agonist.
basal G-protein coupled receptor signaling
G protein-coupled receptor signaling in absence of ligand
G-protein coupled receptor signaling in absence of agonist
G-protein coupled receptor signaling in absence of ligand
G-protein coupled receptor signalling in absence of ligand
Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein.
S1P receptor activity
A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor.
G-protein coupled receptor homodimer
G-protein coupled receptor homodimeric complex
GPCR homodimer
A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR.
G-protein coupled receptor heterodimer
G-protein coupled receptor heterodimeric complex
GPCR heterodimer
Inhibition of one protomer of a G protein-coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit.
cross-receptor inhibition within G-protein coupled receptor heterodimer
The series of molecular signals initiated by interleukin-5 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
IL-5-mediated signaling pathway
interleukin-5-mediated signalling pathway
A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors.
large latent complex
LLC
Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body.
delta-opioid receptor activity
enkephalin receptor activity