NothingMuch/GO-Terms huggingface dataset:
Any process that activates or increases the frequency, rate or extent of histidine biosynthetic process.
activation of histidine anabolism
activation of histidine biosynthesis
activation of histidine biosynthetic process
activation of histidine formation
activation of histidine synthesis
positive regulation of histidine anabolism
positive regulation of histidine biosynthesis
positive regulation of histidine formation
positive regulation of histidine synthesis
up regulation of histidine anabolism
up regulation of histidine biosynthesis
up regulation of histidine biosynthetic process
up regulation of histidine formation
up regulation of histidine synthesis
up-regulation of histidine anabolism
up-regulation of histidine biosynthesis
up-regulation of histidine biosynthetic process
up-regulation of histidine formation
up-regulation of histidine synthesis
upregulation of histidine anabolism
upregulation of histidine biosynthesis
upregulation of histidine biosynthetic process
upregulation of histidine formation
upregulation of histidine synthesis
A cartilage extracellular matrix complex that mediates interactions between major components of the extracellular matrix such as collagens and proteoglycans and contributes to their fibrillar network. Exists as an obligate homotrimer.
matrilin family complex
matrilin-1 complex
matrilin-2 complex
matrilin-3 complex
matrilin-4 complex
A bacterial type IIA topoisomerase that is unique in its function of introducing negative supercoils into DNA at the expense of ATP hydrolysis and is also capable of relaxing positive supercoils, an activity shared with topoisomerase IV. Typically, it is composed of two copies each of an A subunit (GyrA) and a B subunit (GyrB).
topoisomerase II complex
The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina.
subapical region of cell
The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster.
centriolar patch
The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.
laryngeal morphogenesis
Binding to coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
CoA binding
Binding to succinyl-CoA, an omega-carboxyacyl-CoA having succinoyl as the S-acyl component.
succinyl-coenzyme A binding
A complex which stabilizes the binding of and correctly positions the outer dynein arm complex along an A-tubule of the flagellar axoneme outer doublet microtubules.
ODA docking complex
ODA-DC
A process in which a protein is transported to, or maintained in, a location within a motile cilium.
protein localization to nonmotile primary cilium
A protein complex that binds to a recombinase and incrseases its activity.
DNA recombinase accessory factor complex
DNA recombinase activator complex
The chemical reactions and pathways resulting in prenyl-FMNH2, an essential cofactor for the decarboxylase enzymes UbiD and Fdc1.
prenyl-FMNH2 anabolism
prenyl-FMNH2 biosynthesis
prenyl-FMNH2 formation
prenyl-FMNH2 synthesis
prenylated FMNH2 anabolism
prenylated FMNH2 biosynthesis
prenylated FMNH2 biosynthetic process
prenylated FMNH2 formation
prenylated FMNH2 synthesis
Binding to prenyl-FMNH2, a flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1.
prenylated FMNH2 binding
A glycocalyx on the the endolymphatic surface of a cochlear hair cell that coats the external surface of each stereocilium and maintains a small distance between adjacent stereocilia in the bundle.
auditory hair cell glycocalyx
stereocilium glycocalyx
Any process that stops, prevents or reduces the frequency, rate or extent of posttranslational protein translocation through the ER membrane.
negative regulation of N-terminal signal peptide-independent translocation into the ER
negative regulation of posttranslational endoplasmic reticulum membrane protein translocation
negative regulation of posttranslational protein targeting to membrane, translocation
negative regulation of SRP-independent endoplasmic reticulum protein-membrane targeting, translocation
The carbohydrate-rich layer lining the vascular endothelium connected to the endothelium through a variety of molecules, mainly proteoglycans and glycoproteins. These form a network in which soluble molecules, either plasma- or endothelium-derived, are incorporated.
endothelial glycocalyx
Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+).
2-iminobutanoate/2-iminopropanoate deaminase
Catalysis of the reaction: 2-iminopropanoate + H2O = NH4(+) + pyruvate.
2-iminobutanoate/2-iminopropanoate deaminase
The chemical reactions and pathways resulting in the breakdown of a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom.
terminal alkyne substituted compound breakdown
terminal alkyne substituted compound catabolic process
terminal alkyne substituted compound catabolism
terminal alkyne substituted compound degradation
The lateral wall of an outer hair cell (OHC) is a unique trilaminate composite consisting of the plasma membrane, an underlying cytoskeletal network containing an actin-spectrin cortical lattice, and an adjacent system of circumferential lamellar organelles known as the subsurface cisternae.
lateral wall of OHC
OHC lateral wall
outer hair cell lateral wall
A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb.
snRNP 7SK
A set of four specialized microtubules that originates from the basal bodies and wraps around the ciliary pocket membrane, likely supporting its distinct flask shape.
ciliary MtQ
Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin organization.
down regulation of heterochromatin organization
down-regulation of heterochromatin organization
downregulation of heterochromatin organization
inhibition of heterochromatin organization
Any process that activates or increases the frequency, rate or extent of heterochromatin organization.
activation of heterochromatin organization
stimulation of heterochromatin organization
up regulation of heterochromatin organization
up-regulation of heterochromatin organization
upregulation of heterochromatin organization
Any process that stops, prevents, or reduces the frequency, rate or extent of the chromosome attachment to the nuclear envelope.
down regulation of chromosome attachment to the nuclear envelope
down-regulation of chromosome attachment to the nuclear envelope
downregulation of chromosome attachment to the nuclear envelope
inhibition of chromosome attachment to the nuclear envelope
Any process that activates or increases the frequency, rate or extent of the chromosome attachment to the nuclear envelope.
activation of chromosome attachment to the nuclear envelope
stimulation of chromosome attachment to the nuclear envelope
up regulation of chromosome attachment to the nuclear envelope
up-regulation of chromosome attachment to the nuclear envelope
upregulation of chromosome attachment to the nuclear envelope
The portion of the plasma membrane surrounding the pellicle, a structure enclosing some parasite cells such as certain apicomplexa and Euglenozoa. These membranes are associated with an infrastructure of microtubules, microfilaments, and other organelles.
pellicle membrane
pellicular plasma membrane
The aggregation, arrangement and bonding together of a set of components to form a paraflagellar rod, a large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme.
paraflagellar rod biogenesis
paraflagellar rod formation
PFR assembly
The aggregation, arrangement and bonding together of a set of macromolecules to form a ciliary centrin arm, a rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules.
ciliary centrin arm formation
Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
viral coreceptor activity
Any process that activates or increases the frequency, rate or extent of cerebral blood circulation.
activation of cerebral blood circulation
positive regulation of cerebrum blood circulation
positive regulation of telencephalon blood circulation
up regulation of cerebral blood circulation
up-regulation of cerebral blood circulation
upregulation of cerebral blood circulation
Any process that stops, prevents or reduces the frequency, rate or extent of cerebral blood circulation.
down regulation of cerebral blood circulation
down-regulation of cerebral blood circulation
downregulation of cerebral blood circulation
inhibition of cerebral blood circulation
negative regulation of cerebrum blood circulation
negative regulation of telencephalon blood circulation
A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells that are distinct from, but colocalize with or are adjacent to, P granules and mutator foci and are associated with RNA metabolism. Z granules have been observed in C. elegans.
germline granule
The cilary pro-basal body is an immature, partially assembled form of a ciliary basal body found next to the basal body of a cilium. Pro-basal bodies are not capable of nucleating a cilium. As the cell progresses through the cell cycle, continuing assembly will convert the pro-basal body into a mature basal body that is capable of nucleating a cilium.
flagellar pro-basal body
flagellar probasal body
pro-basal body
pro-centriole
probasal body
Binding to 2-amino-3-(1H-indol-3-yl)propanoic acid.
Trp binding
Binding to and responding, e.g. by conformational change, to changes in the cellular level of tyrosine.
tyrosine sensing activity
Binding to and responding, e.g. by conformational change, to changes in the cellular level of tryptophan.
tryptophan sensing activity
A cellular localization process where a DNA replication fork that has stalled is signaled to relocate and anchor to the nuclear periphery for the time necessary to complete recombination-dependent replication.
stalled replication fork localization to nuclear periphery involved in replication fork processing
Any process that inhibits or decreases the rate of mitotic recombination-dependent replication fork processing. Suppression of recombination at replication forks is necessary to prevent template switching.
maintenance of template fidelity during replication fork processing
negative regulation of mitotic recombination involved in replication fork processing
negative regulation of template switch recombination involved in replication fork processing
suppression of template switching during replication fork processing
Any process that activates or increases the frequency, rate or extent of mitotic recombination-dependent replication fork processing. Regulation of mitotic recombination prevents recombination between inappropriate homologous sequences. Proteins involved in homologous recombination are required for replication restart.
positive regulation of homologous recombination dependent replication fork recovery
positive regulation of mitotic recombination involved in replication fork processing
positive regulation of recombination-dependent DNA replication
An aggregation of axonemal dyneins, their specific assembly factors, and broadly-acting chaperones that is located in the cytoplasm.
DynAP
Catalysis of the reaction: (L-lysyl- + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-.
histone lactyltransferase (CoA dependent) activity
histone lactyltransferase activity
histone lactyltransferase activity (CoA dependent)
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of perturbations or damage to the actin cytoskeleton.
cellular response to actin cytoskeleton stress
cellular response to latrunculin A
cellular response to latrunculin B
response to latrunculin A
response to latrunculin B
The aggregation, arrangement and bonding together of a set of components to form an axonemal outer doublet, a part of an axoneme consisting of a doublet microtubule.
axonemal outer doublet biogenesis
axonemal outer doublet formation
axonemal outer doublet morphogenesis
axoneme outer doublet assembly
outer doublet assembly
outer-doublet microtubule assembly
A process that is carried out at the cellular level which results in the lateral attachment of the cilium to the cell body via the flagellar attachment zone in some trypanosomatid species.
cilial attachment to cell body
ciliary attachment to cell body
flagellar attachment to cell body
flagellum attachment to cell body
A process that is carried out at the cellular level which results in the conversion of an immature and partially assembled ciliary pro-basal body into a mature basal body that is capable of nucleating a cilium.
flagellar pro-basal body maturation
flagellar probasal body maturation
pro-basal body maturation
The process in which the duplicated basal bodies migrate in pairs to the mitotic poles of the nucleus and results in equal distribution in the daughter cells. Ciliary basal body segregation ensures inheritance of the duplicated mitochondrial DNA to the two daughter cells in the Trypanosoma parasites.
ciliary basal body separation
microtubule basal body segregation
microtubule basal body separation
Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced  = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized
cytochrome P450 fatty acid omega-1 hydroxylase activity
The myosin-based contraction and retraction of a lateral pseudopodium.
lateral pseudopodium suppression
The region of the nuclear envelope situated in close proximity to a nuclear pore complex.
associated with the nuclear pore
nuclear envelope adjacent to NPC
nuclear envelope periphery of the nuclear pore complex
Penetration by a symbiont into a host organism via an appressorium. The host is defined as the larger of the organisms involved in a symbiotic interaction.
appressorium-mediated host invasion
appressorium-mediated host penetration
appressorium-mediated invasion into host
appressorium-mediated penetration into host
A process in which a protein is transported to, or maintained in, a location within a centriolar satellite.
protein localisation to centriolar satellite
A conserved RNA endonuclease complex required for spreading and epigenetic inheritance of heterochromatin. The rixosome contains six unique subunits: three structural subunits (Crb3, Rix1, and Ipi1) which form the core of the complex, and three catalytic subunits (the endonuclease Las1, the polynucleotide kinase Grc3, and the AAA-type ATPase Mdn1), which are involved in the processing of ribosomal RNA precursors. All subunits are essential for viability and are conserved from yeast to mammals, including humans.
rix1 complex
The biological process involved in maintaining the steady-state number of cells within a population of free-living cells, such as the bacteria, in the mouth.
host-induced regulation of oral microbiota composition
The portion of the radial spoke 1 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme.
radial spokehead 1
The portion of the radial spoke 2 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme.
radial spokehead 2
The portion of the radial spoke 3 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme.
radial spokehead 3
A heterodimeric E1 complex that activates the ubiquitin-like protein NEDD8. In humans the subunits are NAE1 (also known as APPBP1) and UBA3.
APPBP1-UBA3 complex
NAE
NEDD8 activating enzyme
A heterodimeric complex capable of glycosyltransferase activity required for the elongation of heparan sulfate chains. In humans, the complex consists of EXT1 and EXT2. In Drosophila, the complex consists of ttv and sotv.
exostosin complex
EXT1-EXT2 heparan sulfate biosynthesis complex
A protein complex that catalyzes the base-exchange of a guanine residue with queuine at the wobble position of the anticodon of tRNAs. The eukaryotic tRNA-guanine transglycosylase exists as a heterodimer of a catalytic subunit (QTRT1 in humans) and an accessory subunit (QTRT2 in humans), whereas the bacterial enzyme is homodimeric.
queuine tRNA-ribosyltransferase complex
TGT
A protein complex capable of catalyzing the reaction of GTP and mannose-1-phosphate to form GDP-mannose. The complex is a homodimer in most bacteria and a heterodimer in most eukaryotes. In humans, it is composed of a catalytic beta subunit (GMPPB) and a regulatory alpha subunit (GMPPA).
GMPPA-GMPPB complex
A protein complex capable of condensing two 2Fe-2S clusters into one 4Fe-4S center in mitochondria. In S. cerevisiae, it consists of Isa1 and Isa2. In humans it consists of ISCA1 and ISCA2. Additional proteins may be present.
iron-sulfur assembly complex
ISA complex
Catalysis of the reaction: methyl (2E,6E)-farnesoate + O2 + reduced  = H+ + H2O + juvenile hormone III + oxidized .
CYP15A1 activity
Catalysis of the reaction: (2E,6E)-farnesoate + O2 + reduced  = H+ + H2O + juvenile hormone III carboxylate + oxidized .
CYP15C1 activity
A protein complex capable of catalysing the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the histidine residue of translation elongation factor 2 (EF2), which is the first step in the biosynthesis of diphthamide. The complex is a Dph2 homodimer in archaea and a Dph1-Dph2 heterodimer in eukaryotes.
Dph1-Dph2 complex
The chemical reactions and pathways resulting in the formation of UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate.
UDP-D-glucose biosynthesis
UDP-D-glucose biosynthetic process
UDP-glucose biosynthesis
uridine diphosphate glucose biosynthesis
uridine diphosphate glucose biosynthetic process
A giant secretory organelle that comprises a bulb-shape capsule containing a coiled hollow tubule structure attached to it. A cnida defines the phylum Cnidaria.
cnidae (plural)
The removal of an amine group from an adenosine to produce inosine within a tRNA molecule.
A-to-I tRNA editing
The initial, indirect interaction between a contractile vacuole membrane and a site of discharge in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.
contractile vacuole tethering to plasma membrane
The dissociation of the contractile vacuole after discharge, from the plasma membrane. This interaction is mediated by detethering factors that initiate the process of tubulation and fragmentation of the empty contractile vacuole bladder, which is then reincorporated into the CV network.
contractile vacuole detethering from plasma membrane
The directed movement of the contractile vacuole to a specific location.
establishment of contractile vacuole localization
A molecular adaptor that recognizes and binds a target protein containing a SUMO modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.
SUMO-dependent protein binding
A process that results in the assembly, arrangement of constituent parts of a lipid droplet.
adiposome formation
lipid body formation
lipid particle formation
Any process in which a lipid droplet is transported to, or maintained to the prospore membrane leading edge.
adiposome localization to ascospore-type prospore membrane leading edge
adiposome localization to forespore membrane leading edge
adiposome localization to FSM membrane leading edge
lipid body localization to ascospore-type prospore membrane leading edge
lipid body localization to forespore membrane leading edge
lipid body localization to FSM membrane leading edge
lipid particle localization to ascospore-type prospore membrane leading edge
lipid particle localization to forespore membrane leading edge
lipid particle localization to FSM membrane leading edge
The directed movement of manganese ions from inside of a cell, across the plasma membrane and into the extracellular region.
manganese ion export from cell
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus.
cellular response to ox-LDL particle stimulus
cellular response to oxidised LDL particle stimulus
cellular response to oxidized LDL particle stimulus
cellular response to oxidized low-density lipoprotein particle stimulus
cellular response to oxLDL particle stimulus
Enables the energy-independent facilitated diffusion of hydrogen peroxide through a transmembrane aqueous pore or channel.
hydrogen peroxide transmembrane transporter activity
Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
AP endonuclease class I activity
AP lyase activity
AP site-DNA 5\'-phosphomonoester-lyase activity
class I AP endonuclease activity
class I DNA-(apurinic or apyrimidinic site) lyase activity
DNA-(apurinic or apyrimidinic site) 5\'-phosphomonoester-lyase activity
DNA-(apurinic or apyrimidinic site) lyase activity
The fusion of haploid amoebae cells with matching mating types to form a larger cell, which ingests additional amoebae and forms a cellulose wall. The resulting macrocyst undergoes recombination and meiosis followed by release of haploid amoebae. An example of this process can be found in Dictyostelium discoideum.
macrocyst formation
sexual fusion
A muscle cell-specific SWI/SNF-type complex that contains eight to fourteen proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes, and the muscle-specific product of the DPF3/BAF45C gene or an ortholog thereof.
muscle-specific BAF complex
muscle-specific SWI/SNF complex
muscle-type BAF complex
muscle-type SWI/SNF complex
A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180.
brain-specific BAF complex
brain-specific SWI/SNF complex