NothingMuch/GO-Terms huggingface dataset:
Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
low affinity IgA receptor activity
Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
high affinity IgM receptor activity
Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
low affinity IgM receptor activity
A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon.
protein localisation to paranode region of axon
A protein complex having ribose phosphate diphosphokinase activity.
phosphoribosylpyrophosphate synthetase complex
PRPP synthetase complex
A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
MAML1-CSL-ICN1
MAML1-CSL-Notch1 complex
MAML1-RBP-Jkappa-Notch1 complex
A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.
sperm protein complex I
Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response.
somatic hypermutation of antibody genes during immune response
somatic hypermutation of immunoglobulin genes during immune response
The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response.
gene conversion of antibody genes during immune response
gene conversion of immunoglobulin genes during immune response
A behavioral response resulting from wounding.
behavioural response to wounding
A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism.
behavioural defense response to insect
A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism.
behavioural defense response to nematode
The series of molecular signals initiated by a ligand binding to a killer cell immunoglobulin-like receptor capable of cellular activation.
stimulatory killer cell immunoglobulin-like receptor signalling pathway
stimulatory KIR signaling pathway
The series of molecular signals initiated by the binding of C-type lectin to its receptor on the surface of a target cell, and resulting in cellular activation.
stimulatory C-type lectin receptor signalling pathway
stimulatory Ly49 family receptor signaling pathway
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
activation of antiviral response by host
positive regulation of antiviral response by host
stimulation of antiviral response by host
up regulation of antiviral response by host
up-regulation of antiviral response by host
upregulation of antiviral response by host
The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.
immune cell chemotaxis during inflammatory response
leucocyte chemotaxis during inflammatory response
leukocyte chemotaxis during inflammatory response
The movement of an immune cell in response to an external stimulus a part of an immune response.
immune cell chemotaxis during immune response
leucocyte chemotaxis during immune response
The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal.
detection of ER overloading
The series of events leading to removal of necrotic debris that contribute to an inflammatory response.
clearance of damaged tissue during inflammatory response
A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
endothelial cell activation within high endothelial venule during immune response
A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
astrocyte activation during immune response
A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
follicular dendritic cell activation during immune response
The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response.
plasmacytoid dendritic cell differentiation during immune response
The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
monocyte activation during immune response
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
microglial cell activation during immune response
The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response.
myeloid dendritic cell differentiation during immune response
The expansion of a NK T cell population by cell division as part of an immune response.
natural killer T lymphocyte proliferation during immune response
natural killer T-cell proliferation during immune response
natural killer T-lymphocyte proliferation during immune response
NK T cell proliferation during immune response
NK T lymphocyte proliferation during immune response
NK T-cell proliferation during immune response
NK T-lymphocyte proliferation during immune response
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis.
T-helper 1 cell fate commitment
Th1 cell lineage commitment
Th1 fate commitment
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy.
T-helper 2 cell fate commitment
Th2 fate commitment
The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
CD8-positive, alpha-beta intraepithelial T cell development
CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation
CD8-positive, alpha-beta intraepithelial T-cell differentiation
CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation
The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
CD4-positive, alpha-beta intraepithelial T cell development
CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation
CD4-positive, alpha-beta intraepithelial T-cell differentiation
CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation
The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
CD8-positive, alpha-beta intraepithelial T cell development
CD8-positive, alpha-beta T cell differentiation during immune response
CD8-positive, alpha-beta T lymphocyte differentiation during immune response
CD8-positive, alpha-beta T-cell differentiation during immune response
CD8-positive, alpha-beta T-lymphocyte differentiation during immune response
The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
gamma-delta T cell development involved in immune response
gamma-delta T cell differentiation during immune response
gamma-delta T lymphocyte differentiation during immune response
gamma-delta T-cell differentiation during immune response
gamma-delta T-lymphocyte differentiation during immune response
The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
CD8-positive, gamma-delta intraepithelial T cell development
CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation
CD8-positive, gamma-delta intraepithelial T-cell differentiation
CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation
The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
CD4-positive, gamma-delta intraepithelial T cell development
CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation
CD4-positive, gamma-delta intraepithelial T-cell differentiation
CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation
The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell.
CD8-positive, alpha-beta regulatory T cell development
CD8-positive, alpha-beta regulatory T lymphocyte differentiation
CD8-positive, alpha-beta regulatory T-cell differentiation
CD8-positive, alpha-beta regulatory T-lymphocyte differentiation
The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell.
CD8-positive, alpha-beta cytotoxic T cell development
CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation
CD8-positive, alpha-beta cytotoxic T-cell differentiation
CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation
The expansion of a gamma-delta T cell population by cell division as part of an immune response.
gamma-delta T cell proliferation during immune response
gamma-delta T lymphocyte proliferation during immune response
gamma-delta T-cell proliferation during immune response
gamma-delta T-lymphocyte proliferation during immune response
The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).
germinal center B cell development
germinal center B lymphocyte differentiation
germinal center B-cell differentiation
germinal center B-lymphocyte differentiation
The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
marginal zone B cell development
marginal zone B lymphocyte differentiation
marginal zone B-cell differentiation
marginal zone B-lymphocyte differentiation
The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region.
follicular B cell development
follicular B lymphocyte differentiation
follicular B-cell differentiation
follicular B-lymphocyte differentiation
The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody.
memory B cell development
memory B lymphocyte differentiation
memory B-cell differentiation
memory B-lymphocyte differentiation
The expansion of a B cell population by cell division following B cell activation during an immune response.
B cell proliferation during immune response
B lymphocyte proliferation during immune response
B-cell proliferation during immune response
B-lymphocyte proliferation during immune response
Expression of a single heavy chain allele during pre-B cell differentiation.
pre-B lymphocyte allelic exclusion
The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21.
T1 stage B cell differentiation
transitional one stage B cell development
transitional one stage B lymphocyte differentiation
transitional one stage B-cell differentiation
transitional one stage B-lymphocyte differentiation
The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21.
T2 stage B cell differentiation
transitional two stage B cell development
transitional two stage B lymphocyte differentiation
transitional two stage B-cell differentiation
transitional two stage B-lymphocyte differentiation
The process in which an immature B cell becomes committed to become a B-1 B cell.
B-1 B lymphocyte lineage commitment
B-1 B-cell lineage commitment
B-1 B-lymphocyte lineage commitment
The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.
B-1a B cell development
B-1a B lymphocyte differentiation
B-1a B-cell differentiation
B-1a B-lymphocyte differentiation
The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5.
B-1b B cell development
B-1b B lymphocyte differentiation
B-1b B-cell differentiation
B-1b B-lymphocyte differentiation
The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation.
peripheral B lymphocyte receptor editing
peripheral B-cell receptor editing
peripheral B-lymphocyte receptor editing
Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors.
central B lymphocyte positive selection
central B-cell positive selection
central B-lymphocyte positive selection
Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors.
peripheral B lymphocyte positive selection
peripheral B-cell positive selection
peripheral B-lymphocyte positive selection
Any process leading to negative selection of B cells in the bone marrow.
central B lymphocyte negative selection
central B-cell negative selection
central B-lymphocyte negative selection
Any process leading to negative selection of B cells in the periphery.
peripheral B lymphocyte negative selection
peripheral B-cell negative selection
peripheral B-lymphocyte negative selection
The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus.
B lymphocyte homeostatic proliferation
B-cell homeostatic proliferation
B-lymphocyte homeostatic proliferation
The expansion of a B-1 B cell by cell division. Follows B cell activation.
B-1 B lymphocyte proliferation
B-1 B-cell proliferation
B-1 B-lymphocyte proliferation
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment
CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment
CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment
The process in which a pro-T cell becomes committed to becoming an NK T cell.
natural killer T lymphocyte lineage commitment
natural killer T-cell lineage commitment
natural killer T-lymphocyte lineage commitment
NK T lymphocyte lineage commitment
NK T-cell lineage commitment
NK T-lymphocyte lineage commitment
The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell.
gamma-delta T lymphocyte lineage commitment
gamma-delta T-cell lineage commitment
gamma-delta T-lymphocyte lineage commitment
The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
platelet activating factor production
platelet activating factor production involved in acute inflammatory response
platelet activating factor secretion
platelet activating factor secretion involved in acute inflammatory response
platelet activating factor secretion involved in inflammatory response
Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT).
nasal tolerance
tolerance induction in NALT
Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells.
B cell tolerance induction in MALT
Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells.
T cell tolerance induction in MALT
The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue.
antigen sampling by dendritic cells in MALT
The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT.
antigen transcytosis by M cells in MALT
antigen transport by M cells in MALT
antigen transport by M cells in mucosal-associated lymphoid tissue
The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa.
antibody transcytosis mediated by pIgR
immunoglobulin transcytosis mediated by pIgR
The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals.
IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor
B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor.
B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen
B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen
B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen
B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis.
B lymphocyte antigen processing and presentation following pinocytosis
B-cell antigen processing and presentation following pinocytosis
B-lymphocyte antigen processing and presentation following pinocytosis
The process of immune complex clearance by erythrocytes. The process often starts with binding of complement receptor 1 (CR1) on the surface of erythrocytes to a complement coated immune complex. The complex bound to erythrocyte CR1 is then transported to the liver or spleen where it is presented to phagocytes. The process ends when the complex is removed from CR1, allowing the erythrocyte to return to general circulation.
immune complex clearance by RBCs
immune complex clearance by red blood cells
An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae).
adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains
adaptive immune response based on somatic recombination of VLR built from LRR domains
adaptive immune response in jawless fish
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.
cross presentation
cross-presentation
exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent
TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I
TAP-dependent exogenous peptide antigen processing and presentation via MHC class I