NothingMuch/GO-Terms huggingface dataset:
Binding to a cytokine receptor.
hematopoietin/interferon-class (D200-domain) cytokine receptor binding
hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
Binding to an interleukin-1 receptor.
IL-1
interleukin-1 receptor ligand
Blocks the binding of interleukin-1 to the interleukin-1 receptor complex.
IL-1ra
Binding to an interleukin-8 receptor.
IL-8
interleukin-8 receptor ligand
Binding to a transforming growth factor beta receptor.
activin
inhibin
TGF-beta receptor binding
TGFbeta receptor binding
transforming growth factor beta
transforming growth factor beta ligand binding to type I receptor
transforming growth factor beta ligand binding to type II receptor
transforming growth factor beta receptor anchoring activity
transforming growth factor beta receptor ligand
Binding to a neurotrophin receptor.
neurotrophin
neurotrophin receptor ligand
Binding to a neurotrophin TRK receptor.
neurotrophin TRK receptor ligand
Binding to a vascular endothelial growth factor receptor.
vascular endothelial growth factor
vascular endothelial growth factor receptor ligand
VEGF receptor binding
VEGFR binding
Binding to an integrin.
integrin ligand
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
cAMP generating peptide activity
glycopeptide hormone
lipopeptide hormone
peptide hormone
The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.
neurohormone
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
core extracellular matrix
core matrisome
extracellular matrix glycoprotein
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
carrier
Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
ion channel activity
Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
intracellular ligand-gated ion channel activity
intracellular ligand-gated monoatomic ion channel activity
Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration and is sensitive to the plant alkaloid ryanodine.
caffeine-sensitive calcium-release channel
ryanodine receptor
Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts.
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
inositol-1,4,5-trisphosphate receptor activity
InsP3 receptor
IP3 receptor activity
Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts.
intracellular cyclic nucleotide activated cation channel activity
intracellular cyclic nucleotide activated monoatomic cation channel activity
intracellular cyclic nucleotide-activated monoatomic cation channel activity
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts.
HCN channel activity
hyperpolarization-activated cyclic nucleotide-gated channel activity
intracellular 3\',5\' cAMP activated cation channel activity
intracellular 3\',5\'-cAMP activated cation channel activity
intracellular adenosine 3\',5\'-cyclophosphate activated cation channel activity
intracellular cAMP activated cation channel activity
intracellular cAMP-activated cation channel activity
intracellular cyclic AMP activated cation channel activity
Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.
volume-regulated channel
Enables the transmembrane transfer of an inorganic cation by a channel that opens when a calcium cation has been bound by the channel complex or one of its constituent parts.
calcium activated cation channel activity
intracellular calcium-activated potassium channel
polycystin
Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts.
extracellular ligand-gated ion channel activity
Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
extracellular-glutamate-gated ion channel activity
Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels.
inhibitory extracellular ligand-gated ion channel activity
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
Kir channel activity
A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
connexin
innexin
innexin channel activity
intercellular channel
Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage gated ion channel activity
voltage-dependent ion channel activity
voltage-gated ion channel activity
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
depolarization-activated calcium channel
depolarization-activated voltage gated calcium channel activity
depolarization-activated voltage-gated calcium channel
depolarization-activated voltage-gated calcium channel activity
dihydropyridine-sensitive calcium channel activity
voltage gated calcium channel activity
voltage-dependent calcium channel activity
voltage-gated calcium ion channel activity
voltage-sensitive calcium channel
Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage gated chloride channel activity
voltage-dependent chloride channel activity
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage gated sodium channel activity
voltage-dependent sodium channel activity
voltage-gated sodium ion channel activity
voltage-sensitive sodium channel
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage gated potassium channel activity
voltage-dependent potassium channel activity
voltage-gated potassium ion channel activity
voltage-sensitive potassium channel
Enables the energy-independent facilitated diffusion of a monoatomic anion through a transmembrane aqueous pore or channel.
anion channel activity
non-selective anion channel activity
Enables the energy-independent facilitated diffusion of a monoatomic cation through a transmembrane aqueous pore or channel.
cation channel activity
cation diffusion facilitator activity
non-selective cation channel activity
Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.
amine/amide/polyamine channel activity
amine/polyamine transmembrane transporter activity
amino acid-polyamine transmembrane transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in).
cation/amino acid symporter
hydrogen:amino acid symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in).
glutamate/aspartate:sodium symporter activity
insulin-activated sodium/amino acid transporter activity
insulin-activated sodium:amino acid symporter activity
insulin-activated sodium:amino acid transporter activity
isoleucine/valine:sodium symporter activity
sodium/amino acid transporter activity
sodium/excitatory amino acid cotransporter activity
sodium/excitatory amino acid symporter activity
sodium:amino acid symporter activity
sodium:amino acid transporter activity
threonine/serine:sodium symporter activity
Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high affinity basic amino acid transmembrane transporter activity
high-affinity basic amino acid transporter activity
Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
histidine/arginine/lysine/ornithine porter activity
L-histidine transporter activity
Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
neutral L-amino acid porter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in).
neutral amino acid-sodium cotransporter
neutral amino acid:sodium symporter activity
sodium/neutral amino acid transporter
Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid.
L-tyrosine permease activity
L-tyrosine transporter activity
valine/tyrosine/tryptophan permease activity
Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups.
dicarboxylate (succinate/fumarate/malate) antiporter activity
dicarboxylate carrier
dicarboxylic acid permease activity
sodium:dicarboxylate/tricarboxylate symporter activity
Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
glutamate transmembrane transporter activity
glutamate/aspartate porter activity
glutamate/aspartate:sodium symporter activity
L-glutamate transporter activity
Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
inorganic phosphate transmembrane transporter activity
Enables the directed movement of lipids into, out of or within a cell, or between cells.
apolipoprotein
lipophorin
Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
long-chain fatty acid transporter activity
Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
neurotransmitter transporter activity
Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other.
intracellular nucleoside transmembrane transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in).
sodium/chloride-dependent organic acid cotransporter activity
sodium:dicarboxylate/tricarboxylate symporter activity
Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other.
purine base transmembrane transporter activity
purine transmembrane transporter activity
Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other.
pyrimidine base transmembrane transporter activity
pyrimidine transmembrane transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in).
cation/sugar symporter activity
hydrogen:sugar symporter activity
hydrogen:sugar transporter activity
lactose/glucose efflux transporter activity
proton:sugar symporter activity
sugar efflux transmembrane transporter activity
sugar porter activity
sugar transporter
sugar:hydrogen ion symporter activity
sugar:hydrogen symporter activity
sugar:proton symporter activity
Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
fructose permease activity
fructose porter activity
Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
galactose/glucose (methylgalactoside) porter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
glucose:proton symporter activity
hydrogen:glucose symporter activity
hydrogen:glucose transporter activity
transepithelial hydrogen/glucose transporter activity
transepithelial hydrogen:glucose symporter activity
transepithelial hydrogen:glucose transporter activity
Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch.
maltose porter activity
Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.
vitamin Bh transporter activity
Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
tricarboxylate carrier activity
Enables the transfer of copper (Cu) ions from one side of a membrane to the other.
copper uptake transmembrane transporter activity
intracellular copper ion transporter
plasma membrane copper transporter
Enables the transfer of iron (Fe) ions from one side of a membrane to the other.
iron cation channel activity
iron channel activity
iron transporter activity
multicopper ferroxidase iron transport mediator activity
transmembrane iron ion permease activity
transmembrane iron permease activity
zinc, iron permease activity
Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
cobalt, zinc uptake permease activity
zinc, cadmium uptake permease activity
zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
zinc, iron permease activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out).
ATP-dependent calcium transmembrane transporter activity
ATPase-coupled calcium transmembrane transporter activity
Ca(2+)-transporting ATPase activity
Ca2+-transporting ATPase activity
calcium efflux ATPase
calcium pump
calcium transmembrane transporter activity, phosphorylative mechanism
calcium transporting ATPase activity
calcium-translocating P-type ATPase activity
calcium-transporting ATPase activity
sarco(endo)plasmic reticulum Ca2+-ATPase
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
Na(+)/K(+)-ATPase activity
Na(+)/K(+)-exchanging ATPase activity
Na+,K+-ATPase activity
Na+/K+-ATPase activity
Na+/K+-exchanging ATPase activity
Na,K-activated ATPase activity
P-type sodium:potassium-exchanging ATPase activity
sodium pump
sodium/potassium-exchanging ATPase activity
sodium/potassium-transporting ATPase activity
sodium:potassium exchanging ATPase activity
sodium:potassium-exchanging ATPase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in).
carbohydrate:cation symporter activity
cation/sugar symporter activity
cation:sugar symporter activity
sugar:cation symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose(out) + Na+(out) = D-glucose(in) + Na+(in).
glucose:sodium symporter activity
sodium/glucose symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in).
nucleoside-sodium cotransporter activity
sodium-dependent nucleoside transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in).
amino acid:cation symporter activity
cation/amino acid symporter activity
cation:amino acid symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
mitochondrial sodium/calcium ion exchange
sodium/calcium exchanger
sodium:calcium exchange
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).
sodium-dependent phosphate transmembrane transporter activity
sodium/phosphate symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out).
inorganic anion exchanger activity
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
ligand
Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).
calciferol binding
cholecalciferol binding
ergocalciferol binding
Binding to an iron (Fe) ion.
iron binding
Binding to a copper (Cu) ion.
copper binding
copper/cadmium binding
Binding to a calcium ion (Ca2+).
calcium ion storage activity
Binding to a protein.
glycoprotein binding
protein amino acid binding
Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.
IGF binding
A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
cell or subcellular entity
cellular component
subcellular entity
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
basal lamina
basement lamina
lamina densa
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
intercellular space
The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi.
fungal-type spore wall
A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
internal to cell
intracellular
nucleocytoplasm
protoplasm
protoplast