NothingMuch/GO-Terms huggingface dataset:
The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
ER translocation
SRP-dependent cotranslational membrane targeting
SRP-dependent cotranslational protein-membrane targeting
The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.
posttranslational endoplasmic reticulum membrane targeting
posttranslational endoplasmic reticulum protein-membrane targeting
posttranslational protein endoplasmic reticulum membrane targeting
posttranslational protein targeting to endoplasmic reticulum membrane
posttranslational protein targeting to ER membrane
SRP-independent endoplasmic reticulum protein-membrane targeting
The process of directing proteins towards the lysosome using signals contained within the protein.
protein-lysosome targeting
The process of directing proteins towards the vacuole, usually using signals contained within the protein.
protein vacuolar targeting
protein-vacuolar targeting
protein-vacuole targeting
vacuolar protein sorting
The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.
mitochondrial protein import
mitochondrial translocation
protein import into mitochondrion
protein targeting to mitochondria
protein-mitochondrial targeting
The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments.
mitochondrial processing
mitochondrial protein processing during import
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
lipid metabolism
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
fatty acid metabolism
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
fatty acid anabolism
fatty acid biosynthesis
fatty acid formation
fatty acid synthesis
The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde.
hexadecanal anabolism
hexadecanal biosynthesis
hexadecanal formation
hexadecanal synthesis
palmitaldehyde biosynthesis
palmitaldehyde biosynthetic process
The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.
fatty acid desaturation
polyunsaturated fatty acid biosynthesis
unsaturated fatty acid anabolism
unsaturated fatty acid biosynthesis
unsaturated fatty acid formation
unsaturated fatty acid synthesis
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
acyl-CoA metabolism
The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity.
neutral lipid metabolism
The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
acylglycerol metabolism
glyceride metabolic process
glyceride metabolism
The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
triacylglycerol metabolic process
triacylglycerol metabolism
triglyceride metabolism
The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.
membrane lipid metabolism
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
phospholipid metabolism
The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
phosphatidylethanolamine anabolism
phosphatidylethanolamine biosynthesis
phosphatidylethanolamine formation
phosphatidylethanolamine synthesis
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
alpha-glycerophosphate pathway
glycerophospholipid metabolism
phosphoglyceride metabolic process
phosphoglyceride metabolism
The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
diacylglycerol anabolism
diacylglycerol biosynthesis
diacylglycerol formation
diacylglycerol synthesis
diglyceride biosynthesis
The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
phosphatidic acid anabolism
phosphatidic acid biosynthesis
phosphatidic acid formation
phosphatidic acid synthesis
The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
phosphatidylglycerol anabolism
phosphatidylglycerol biosynthesis
phosphatidylglycerol formation
phosphatidylglycerol synthesis
The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
phosphatidylcholine anabolism
phosphatidylcholine biosynthesis
phosphatidylcholine formation
phosphatidylcholine synthesis
The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes.
phosphatidylserine metabolism
The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
phosphatidylserine anabolism
phosphatidylserine biosynthesis
phosphatidylserine formation
phosphatidylserine synthesis
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
phosphatidylinositol anabolism
phosphatidylinositol biosynthesis
phosphatidylinositol formation
phosphatidylinositol synthesis
phosphoinositide biosynthesis
phosphoinositide biosynthetic process
PtdIns biosynthesis
PtdIns biosynthetic process
The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol.
glycerol ether metabolism
The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent.
glycolipid metabolism
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
sphingolipid metabolism
The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol.
dihydrosphingosine metabolic process
dihydrosphingosine metabolism
sphinganine metabolism
The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol.
dihydrosphingosine-1-phosphate metabolic process
dihydrosphingosine-1-phosphate metabolism
sphinganine-1-phosphate metabolism
The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
(4E)-sphing-4-enine metabolic process
(4E)-sphing-4-enine metabolism
sphing-4-enine metabolic process
sphing-4-enine metabolism
sphingosine metabolism
The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids.
phytosphingosine metabolism
The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.
ceramide metabolism
The chemical reactions and pathways involving inositol phosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group.
inositol phosphorylceramide metabolic process
inositol phosphorylceramide metabolism
inositolphosphoceramide metabolism
The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative.
mannose inositol phosphoceramide metabolic process
mannose inositol phosphoceramide metabolism
mannose-inositol-P-ceramide (MIPC) metabolic process
mannose-inositol-P-ceramide (MIPC) metabolism
mannosyl-inositol-phosphorylceramide metabolism
MIPC metabolic process
MIPC metabolism
The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group.
glycosylceramide metabolism
The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative.
glucosylceramide metabolism
The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group.
glucosylceramide anabolism
glucosylceramide biosynthesis
glucosylceramide formation
glucosylceramide synthesis
The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group.
glucosylceramide breakdown
glucosylceramide catabolism
glucosylceramide degradation
The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.
galactosylceramide metabolism
The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.
sphingomyelin metabolism
The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
sphingomyelin breakdown
sphingomyelin catabolism
sphingomyelin degradation
The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide.
glycosphingolipid metabolism
The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.
glycosphingolipid anabolism
glycosphingolipid biosynthesis
glycosphingolipid formation
glycosphingolipid synthesis
The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids.
eicosanoid metabolic process
eicosanoid metabolism
icosanoid metabolism
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
leukotriene metabolism
The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure.
prostanoid metabolism
The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
prostaglandin metabolism
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
steroid anabolism
steroid biosynthesis
steroid formation
steroid synthesis
steroidogenesis
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
cholesterol anabolism
cholesterol biosynthesis
cholesterol formation
cholesterol synthesis
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
ergosterol anabolism
ergosterol biosynthesis
ergosterol formation
ergosterol synthesis
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
bile acid anabolism
bile acid biosynthesis
bile acid formation
bile acid synthesis
The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
C21-steroid hormone anabolism
C21-steroid hormone biosynthesis
C21-steroid hormone formation
C21-steroid hormone synthesis
The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.
progesterone anabolism
progesterone biosynthesis
progesterone formation
progesterone synthesis
The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
androgen anabolism
androgen biosynthesis
androgen formation
androgen synthesis
The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
estrogen anabolism
estrogen biosynthesis
estrogen formation
estrogen synthesis
oestrogen biosynthesis
oestrogen biosynthetic process
The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
glucocorticoid anabolism
glucocorticoid biosynthesis
glucocorticoid formation
glucocorticoid synthesis
The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
mineralocorticoid anabolism
mineralocorticoid biosynthesis
mineralocorticoid formation
mineralocorticoid synthesis
The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
steroid breakdown
steroid catabolism
steroid degradation
The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
mineralocorticoid breakdown
mineralocorticoid catabolism
mineralocorticoid degradation
The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
glucocorticoid breakdown
glucocorticoid catabolism
glucocorticoid degradation
The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units.
sesquiterpenoid metabolism
The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.
juvenile hormone metabolism
The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.
juvenile hormone anabolism
juvenile hormone biosynthesis
juvenile hormone formation
juvenile hormone synthesis
The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.
juvenile hormone breakdown
juvenile hormone catabolism
juvenile hormone degradation
The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
isoprenoid metabolism
polyisoprenoid metabolic process
polyisoprenoid metabolism
polyterpene metabolic process
polyterpene metabolism
The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups.
terpenoid metabolism
The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units.
triterpene metabolic process
triterpene metabolism
triterpenoid metabolism
The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye.
eye pigment anabolism
eye pigment biosynthesis
eye pigment formation
eye pigment synthesis
The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
one carbon metabolic process
one carbon metabolism
one-carbon metabolism
one-carbon transfer metabolic process
one-carbon transfer metabolism
The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
NAD (reduced) metabolic process
NAD (reduced) metabolism
NADH metabolism
reduced NAD metabolic process
reduced NAD metabolism
reduced nicotinamide adenine dinucleotide metabolic process
reduced nicotinamide adenine dinucleotide metabolism
A metabolic process that generates a pool of NADH by the reduction of NAD+.
NAD (reduced) regeneration
reduced NAD regeneration
reduced nicotinamide adenine dinucleotide regeneration
The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.
NAD phosphorylation and dephosphorylation
NADP (oxidized) metabolic process
NADP (oxidized) metabolism
NADP (reduced) metabolic process
NADP (reduced) metabolism
NADP metabolism
NADPH metabolic process
NADPH metabolism
nicotinamide adenine dinucleotide phosphate metabolic process
nicotinamide adenine dinucleotide phosphate metabolism
oxidized NADP metabolic process
oxidized NADP metabolism
oxidized nicotinamide adenine dinucleotide phosphate metabolic process
oxidized nicotinamide adenine dinucleotide phosphate metabolism
reduced NADP metabolic process
reduced NADP metabolism
reduced nicotinamide adenine dinucleotide phosphate metabolic process
reduced nicotinamide adenine dinucleotide phosphate metabolism
A metabolic process that generates a pool of NADPH by the reduction of NADP+.
NADP (reduced) regeneration
reduced NADP regeneration
reduced nicotinamide adenine dinucleotide phosphate regeneration
The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme.
coenzyme Q metabolic process
coenzyme Q metabolism
ubiquinone metabolism
The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
coenzyme Q biosynthesis
coenzyme Q biosynthetic process
coenzyme Q10 biosynthesis
coenzyme Q10 biosynthetic process
coenzyme Q6 biosynthesis
coenzyme Q6 biosynthetic process
coenzyme Q8 biosynthesis
coenzyme Q8 biosynthetic process
coenzyme Q9 biosynthesis
coenzyme Q9 biosynthetic process
ubiquinone anabolism
ubiquinone biosynthesis
ubiquinone formation
ubiquinone synthesis
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
glutathione metabolism
oxidized glutathione reduction
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
glutathione anabolism
glutathione biosynthesis
glutathione formation
glutathione synthesis
The chemical reactions and pathways involving any phosphorylated nucleoside.
nucleoside phosphate metabolism
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP anabolism
ATP biosynthesis
ATP formation
ATP regeneration
ATP synthesis
The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.
folate and derivative metabolic process
folate and derivative metabolism
folate-containing compound metabolic process
folate-containing compound metabolism
folic acid and derivative metabolic process
folic acid and derivative metabolism
folic acid-containing compound metabolism
vitamin B9 and derivative metabolic process
vitamin B9 and derivative metabolism
vitamin M and derivative metabolic process
vitamin M and derivative metabolism
The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
vitamin metabolism