NothingMuch/GO-Terms huggingface dataset:
The radial spoke of each group of radial spokes, whether grouped as triplets or doublets, that is immediately distal to radial spoke 1 (RS1). Radial spoke 2 (RS2), similarly to RS1, is comprised of four domains: 1) a very short base anchored to the A microtubule, 2) an elongaged stalk, 3) a bifurcated neck, and 4) an orthogonal head. The base of RS2 is connected to the tail of the inner dynein arm c.
RS2
Radial spoke 3 (RS3), when present, is the most distal of each group of radial spokes, whether grouped as triplets or doublets. RS3 has significantly different morphology and protein composition than RS1 and RS2 and also extends at a slant from the microtubule doublet, rather than perpendicularly like RS1 and RS2. In some organisms (e.g. Chlamydomonas and Sarcophaga bullata), RS3 is represented only as a stump attached to the A-microtubule lacking the rest of the stalk structure and entirely lacking the head structure.
RS3
One of the two nuclear divisions that occur as part of the meiotic cell cycle.
meiosis
A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
mitosis
Binding to a protein upon post-translation modification of the target protein.
modified protein binding
A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.
ubiquitination-like modification-dependent protein binding
ubiquitination-like protein reader activity
A molecular adaptor recognizes and binds a target protein containing a ubiquitination modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.
ubiquitin-dependent protein binding
The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
branching morphogenesis of a neurite
branching morphogenesis of a neuron projection
neurite arborization
neurite branching
neuron projection branching
Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide.
protein crotonyltransferase activity
Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide.
protein butyryltransferase activity
A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes.
EndMT
EndoMT
Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction.
ATP-dependent protein-DNA unloading activity
protein-DNA unloading ATPase activity
The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.
extracellular vesicle assembly
The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region.
efflux
A process by which a symbiont inhibits or disrupts cytokine production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
negative regulation by symbiont of host cytokine production
suppression by symbiont of host cytokine production
suppression by symbiont of host cytokine secretion
Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress.
mechanically-gated cation channel activity
mechanosensitive cation channel activity
Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein.
miRNA transporter activity
nucleocytoplasmic importin/exportin activity
pre-miRNA transporter activity
A membrane-bound intracellular compartment that is formed upon internalization of a pathogen into a host cell, and in which the pathogen resides.
pathogen inclusion
pathogen-containing compartment
A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.
basal transcription factor activity
general transcription factor activity
GTF activity
A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.
cell cell fusion
cell fusion
The entry of a symbiont into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration symbiont protein. This process mediates the entry of some non-enveloped virus into host cells, and results in the release of the virus contents into the host cell cytoplasm.
viral entry via permeabilization of host membrane
The mitotic cell cycle process where kinetochore microtubule attachment defects are corrected.
correction of mitotic kinetochore microtubule attachment defects
repair of mitotic kinetochore microtubule attachment defects
The cell cycle process where kinetochore microtubule attachment defects are corrected.
correction of kinetochore microtubule attachment defects
repair of kinetochore microtubule attachment defects
Any process that modulates the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
regulation of division septum formation involved in mitotic cell cycle
regulation of formation of division septum involved in mitotic cell cycle
regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle
regulation of septin assembly and septum formation involved in mitotic cell cycle
Any process that stops, prevents or reduces the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
down regulation of division septum formation involved in mitotic cell cycle
down regulation of formation of division septum involved in mitotic cell cycle
down regulation of mitotic division septum assembly
down regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle
down regulation of septin assembly and septum formation involved in mitotic cell cycle
down-regulation of division septum formation involved in mitotic cell cycle
down-regulation of formation of division septum involved in mitotic cell cycle
down-regulation of mitotic division septum assembly
down-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle
down-regulation of septin assembly and septum formation involved in mitotic cell cycle
downregulation of division septum formation involved in mitotic cell cycle
downregulation of formation of division septum involved in mitotic cell cycle
downregulation of mitotic division septum assembly
downregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle
downregulation of septin assembly and septum formation involved in mitotic cell cycle
inhibition of division septum formation involved in mitotic cell cycle
inhibition of formation of division septum involved in mitotic cell cycle
inhibition of mitotic division septum assembly
inhibition of septin assembly and septum biosynthesis involved in mitotic cell cycle
inhibition of septin assembly and septum formation involved in mitotic cell cycle
negative regulation of division septum formation involved in mitotic cell cycle
negative regulation of formation of division septum involved in mitotic cell cycle
negative regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle
negative regulation of septin assembly and septum formation involved in mitotic cell cycle
Any process that activates or increases the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
activation of division septum formation involved in mitotic cell cycle
activation of formation of division septum involved in mitotic cell cycle
activation of mitotic division septum assembly
activation of septin assembly and septum biosynthesis involved in mitotic cell cycle
activation of septin assembly and septum formation involved in mitotic cell cycle
positive regulation of division septum formation involved in mitotic cell cycle
positive regulation of formation of division septum involved in mitotic cell cycle
positive regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle
positive regulation of septin assembly and septum formation involved in mitotic cell cycle
up regulation of division septum formation involved in mitotic cell cycle
up regulation of formation of division septum involved in mitotic cell cycle
up regulation of mitotic division septum assembly
up regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle
up regulation of septin assembly and septum formation involved in mitotic cell cycle
up-regulation of division septum formation involved in mitotic cell cycle
up-regulation of formation of division septum involved in mitotic cell cycle
up-regulation of mitotic division septum assembly
up-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle
up-regulation of septin assembly and septum formation involved in mitotic cell cycle
upregulation of division septum formation involved in mitotic cell cycle
upregulation of formation of division septum involved in mitotic cell cycle
upregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle
upregulation of septin assembly and septum formation involved in mitotic cell cycle
Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
activating transcription factor binding
repressing transcription factor binding
transcription activator binding
Uptake of iron into a cell via binding to an extracellular receptor, which is internalized by endocytosis.
iron import into cell by endocytosis
Binding to a molecule and eliciting a change in the protein's activity in response to the intracellular level of that molecule.
small molecular sensor activity
small molecule sensing activity
small molecule sensor activity
Enables the transport of a lipid from a region of a membrane to a different region on the same membrane.
flippase activity
translocase activity
Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery.
endocytic adaptor activity
Directly binding to a specific protein and delivering it to a specific cellular location.
protein carrier activity
protein transport chaperone
Binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor.
decoy death receptor activity
decoy receptor
Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases.
aminophospholipid-transporting ATPase
ATPase-coupled phospholipid transporter activity
ATPase-dependent phospholipid transporter activity
phospholipid flippase activity
phospholipid translocating ATPase activity
phospholipid-translocating ATPase activity
phospholipid-transporting ATPase activity
Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
flippase activity (exoplasmic to cytosolic leaflet)
Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP.
floppase activity (cytosolic to exoplasmic leaflet)
Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
glycerophospholipid flippase activity (exoplasmic to cytosolic leaflet)
The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis.
efflux
The directed movement of a lipid from a cell, into the extracellular region.
lipid efflux
The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
lipid uptake
Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
E1-E2 ATPase
P-type ATPase
Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ABC transporter
ABC-type efflux permease activity
ABC-type efflux porter activity
ABC-type transmembrane transporter activity
ABC-type uptake permease activity
ATP binding cassette transporter
ATP-binding cassette (ABC) transporter activity
ATP-binding cassette transporter
Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out).
ATPase-coupled azole transmembrane transporter activity
azole ABC transporter activity
A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
effector dependent suppression of host immune innate response by symbiont
effector triggered suppression of host immune innate response by symbiont
effector-dependent suppression of host immune innate response by symbiont
effector-mediated suppression of host immune innate response by symbiont
effector-mediated suppression of host innate immune response by symbiont
effector-mediated suppression of host innate immunity
effector-triggered suppression of host immune innate response by symbiont
A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
effector mediated modulation of host immune response by symbiont
effector triggered modulation of host immune response by symbiont
effector-dependent modulation of host immune response by symbiont
effector-mediated modulation of host immunity
effector-mediated modulation of host innate immune response by symbiont
effector-triggered modulation of host immune response by symbiont
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in).
monoatomic cation:hydrogencarbonate symporter activity
solute:bicarbonate symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) = zinc(in) + HCO3-(in).
zinc:hydrogencarbonate symporter activity
Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate.
carrier protein activity
A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host structure or process. The host is defined as the larger of the organisms involved in a symbiotic interaction.
effector mediated modulation of host process by symbiont
effector triggered modulation of host process by symbiont
effector-dependent modulation of host process by symbiont
The directed movement of a heme from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
heme assimilation
The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand.
ligand maturation
signal maturation
The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex.
chromatin adaptor
chromatin adaptor activity
chromatin receptor
chromatin recruitment
chromatin-protein adaptor
protein-chromatin adaptor activity
The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.
ISR
Any process that modulates the frequency, rate or extent of reticulophagy.
regulation of autophagy of the endoplasmic reticulum
regulation of autophagy of the ER
regulation of endoplasmic reticulum autophagy
regulation of endoplasmic reticulum degradation
regulation of ER autophagy
regulation of ER degradation
regulation of ER-phagy
Degradation of a lipid droplet by microautophagy.
lipid droplet autophagy
The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells.
granzyme-mediated cell death signaling pathway
A narrow constricted region of the nucleus that forms around the anaphase spindle during closed mitosis, and connects the main portions of the newly forming daughter nuclei.
nuclear bridge
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.
nuclear complex
The cellular synthesis of Piwi-interacting RNA piRNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
Piwi-associated RNA transcription
PIWI-interacting RNA transcription
A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery.
epigenetic reader
histone reader
Bridging together two DNA loop anchors together, maintaining a chromatin loop.
chromosomal loop binding
DNA loop binding
A chromatin organization process that starts with the loading of an extrusion motor (by an SMC family complex) onto the chromatin, followed by chromatin extrusion that stops at loop anchoring sites on the chromosome.
chromatin folding
chromatin loop assembly
DNA loop extrusion
DNA looping
A process mediated by a molecule secreted by a symbiont that results in the suppression of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
effector-mediated suppression of host defenses
effector-mediated suppression of host defenses by symbiont
Binding to and carrying a protein between two different cellular components by moving along with the target protein.
protein carrier activity
protein chaperone
A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signaling response.
DNA damage sensing activity
The radial migration of a pyramidal neuron along radial glial cells.
radial glia-dependent neuronal migration
A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP hydrolysis-dependent activity
ATPase activity
ATPase activity, coupled
ATPase-dependent activity
An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.
ATP hydrolysis-dependent chromatin remodeler activity
ATP-dependent chromatin remodeller activity
ATP-dependent chromatin remodelling
ATPase-dependent chromatin remodeler activity
nucleosome-activated ATPase activity
nucleosome-dependent ATPase activity
Binds to and modulates the activity of a motor protein.
motor activity regulator activity
An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule.
renaturation
Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome, driven by ATP hydrolysis.
ATP-dependent histone loader activity
ATP-dependent histone unloader activity
histone loader activity
histone loading activity
histone unloader activity
histone unloading activity
nucleosome remodeling activity
The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.
non-membrane-bounded organelle assembly
non-membrane-bounded organelle formation
non-membrane-enclosed organelle assembly
non-membrane-enclosed organelle formation
Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP.
cyclic-GMP-AMP synthase activity
A type of non-canonical Wnt signaling in which Wnt binding to its receptor on the surface a the target cell results in internalization and cleavage of the frizzled receptor to yield a C-terminal fragment that is imported into the nucleus. The frizzled C-terminal fragment is incorporated into large ribonucleoprotein particles and stimulates their egress via nuclear budding.
FNI
Frizzled Nuclear Import Wnt Pathway