NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: L-lysyl27- + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27- + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2.
histone H3-K27 dimethylase activity
histone H3-K27 dimethylation
histone H3K27 dimethylase activity
histone H3K27 dimethylation
histone H3K27 mono/dimethylase activity
histone lysine N-dimethyltransferase activity (H3-K27 specific)
Catalysis of the reaction: L-lysyl27- + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl27- + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me.
histone H3-K27 methylation
histone H3-K27 monomethylase activity
histone H3K27 methylation
histone H3K27 monomethylase activity
histone lysine N-monomethyltransferase activity (H3-K27 specific)
Catalysis of the reaction: L-lysyl36- + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl36- + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me2.
histone H3-K36 dimethylation
histone H3K36 dimethylase activity
histone H3K36 dimethylation
histone H3K36 mono/dimethylase activity
histone lysine N-dimethyltransferase activity (H3-K36 specific)
Catalysis of the reaction: L-lysyl36- + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36- + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3.
histone H3-K36 trimethylation
histone H3K36 mono/di/trimethylase activity
histone H3K36 trimethylase activity
histone H3K36 trimethylation
histone lysine N-trimethyltransferase activity (H3-K36 specific)
Catalysis of the reaction: L-lysyl79- + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79- + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3.
histone H3-K79 trimethylation
histone H3K79 trimethylase activity
histone H3K79 trimethylation
histone lysine N-trimethyltransferase activity (H3-K79 specific)
histone trimethylase activity (H3-K79 specific)
histone trimethyltransferase activity (H3-K79 specific)
histone-H3K79 trimethyltransferase activity
The process in which a miRNA is targeted for degradation by a non-coding RNA or mRNA. The binding of an RNA to a target miRNA within a RISC complex results in either ubiquitin-mediated degradation of AGO protein or the displacement of the 3' end of the miRNA, exposing it to nucleases.
target-directed microRNA degradation
TDMD
A homeostatic process involved in the maintenance of a steady state level of auxin within a cell.
auxin homeostasis
cellular auxin homeostasis
A process leading to the generation of a functional secondary piRNA, involving a self-perpetuating piRNA loop, often called the ping-pong cycle, in which piRNAs are amplified by pairing with complementary transcripts (for example the transposable element mRNA target). In Drosophila, the processing involves the piwi proteins aubergine and Argonaute 3 and in mice, the piwi proteins Piwil2 and Piwil4.
ping-pong amplification
ping-pong derived piRNA
secondary piRNA biogenesis
secondary PIWI-associated RNA processing
The directed movement of mangnanese ions from outside of a cell into a cell.
manganese influx
Enables the transfer of various organic cations in exchange for a proton, according to the reaction: H+(out) + organic cation(in) = H+(in) + organic cation(out). The transported substrates are usually toxic molecules, drugs and xenobiotics.
proton:polyspecific organic cation antiporter activity
The cellular processes and signaling pathways by which a cell responds to disruption of the integrity of its plasma membrane by another organism. Some toxins produced by other organisms can form pores in membranes, or affect the membrane permeability.
defense response against disruption of plasma membrane integrity
Binding to a mitochondrial large ribosomal subunit.
mitochondrial ribosomal large subunit binding
Any process that reduce or remove the toxicity of aluminum ions. These can include transport of the aluminum away from sensitive areas, sequesteration, or chemical modification to an inert form.
aluminum ion homeostasis
Catalysis of the reaction: Ca2+(in) + Mn2+(out) = Ca2+(out) + Mn2+(in).
manganese:calcium antiporter activity
Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 12) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 12). This reaction is the addition of a methyl group to the lysine residue at position 12 of the histone H4 protein.
histone H4 lysine 12-specific methyltransferase activity
histone H4K12 methylase activity
histone H4K12 methylation
histone lysine N-methyltransferase activity (H4-K12 specific)
histone methylase activity (H4-K12 specific)
histone methyltransferase activity (H4-K12 specific)
histone-H4K12 methyltransferase activity
Combining with a chemorepellent and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
G protein chemorepellent receptor activity
G-protein chemorepellent receptor activity
G-protein coupled chemorepellent receptor activity
Enables the transfer of ATP from one side of a membrane to the other according to the reaction: ATP(out) + phosphate(in) = ATP(in) + phosphate(out).
ATP:inorganic phosphate antiporter activity
inorganic phosphate:ATP antiporter activity
Enables the transfer of ADP from one side of a membrane to the other according to the reaction: ADP(out) + phosphate(in) = ADP(in) + phosphate(out).
ADP:inorganic phosphate antiporter activity
inorganic phosphate:ADP antiporter activity
Catalysis of the reaction: L-lysyl4- + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4- + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3.
histone H3-K4 trimethylation
histone H3K4 trimethylase activity
histone H3K4 trimethylation
histone lysine N-trimethyltransferase activity (H3-K4 specific)
Catalysis of the transfer of a ubiquitin molecule to histone 4 at the lysine-91 residue.
histone H4-K91 ubiquitin ligase activity
histone ubiquitin ligase activity (H4-K91 specific)
A transposable element silencing mechanism in which a Piwi-associated RNA (piRNA) triggers heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription.
piRNA-mediated retrotransposon silencing by heterochromatin formation
A transposable element silencing mechanism in which a siRNA triggers heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription.
siRNA-mediated retrotransposon silencing by heterochromatin formation
A transposable element silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation by a Piwi-associated RNA (piRNA).
piRNA-mediated post-transcriptional retrotransposon silencing
piRNA-mediated retrotransposon silencing by mRNA destabilization
A transposable element silencing mechanism mediated by RNA-directed DNA methylation. RNA-directed DNA methylation is a gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription.
retrostransposon silencing by RdDM
retrotransposon silencing by RNA-directed DNA methylation
retrotransposon silencing by siRNA-directed DNA methylation
transposable element silencing by siRNA-directed DNA methylation
A transposable element silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation by a siRNA.
siRNA-mediated post-transcriptional retrotransposon silencing
siRNA-mediated retrotransposon silencing by mRNA destabilization
The attachment of a symbiont to its host by binding to a component of the host extracellular matrix. The host is defined as the larger of the organisms involved in a symbiotic interaction.
adhesion of symbiont to host extracellular matrix via collagen
adhesion of symbiont to host extracellular matrix via fibronectin
adhesion of symbiont to host extracellular matrix via integrin
adhesion of symbiont to host extracellular matrix via laminin
adhesion of symbiont to host extracellular matrix via vitronectin
A process in which a symbiont alters or subverts host cell adhesion ito its extracellular matrix. The host is defined as the larger of the organisms involved in a symbiotic interaction.
disruption by symbiont of host cell-cell adhesion
The process in which an organism effects a change that impairs the structure or function of the host microtubule cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction.
disruption by symbiont of host microtubule cytoskeleton
modification by symbiont of host microtubule cytoskeleton
perturbation by symbiont of host microtubule cytoskeleton
A process in which a symbiont alters or subverts focal adhesion in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
disruption by symbiont of host focal adhesion
The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by actin crosslinking the host actin filaments. The host is defined as the larger of the organisms involved in a symbiotic interaction.
perturbation by symbiont of host actin cytoskeleton via actin crosslinking
The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by reorganizing the actin filaments, in a way that keeps the total filementous actin remains approximately constant. The host is defined as the larger of the organisms involved in a symbiotic interaction.
perturbation by symbiont of host actin cytoskeleton via actin filament rearrangement
perturbation by symbiont of host actin cytoskeleton via actin filament reorganization
The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by polymerizing the host filamentous actin. The host is defined as the larger of the organisms involved in a symbiotic interaction.
perturbation by symbiont of host actin cytoskeleton via actin polymerization
The process in which an organism effects a change that disrupts the host actin cytoskeleton by inhibiting host actin from polymerizing. The host is defined as the larger of the organisms involved in a symbiotic interaction.
perturbation by symbiont of host actin cytoskeleton via inhibition of actin polymerization
Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H+.
DAG kinase activity
diacylglycerol kinase (CTP dependent)
diacylglycerol kinase activity
diacylglycerol kinase activity (CTP)
The production by a symbiont of high levels of cyclic AMP in a host cell, impairing host cellular functions in multiple ways, including ATP depletion, interference with host intracellular signaling, cytoskeletal defects and apoptosis-related cell death. The host is defined as the larger of the organisms involved in a symbiotic interaction.
cAMP intoxication in host
The global programming of epigenetic modifications following binucleate central cell fertilization. This involves DNA methylation at the silent allele. In the endosperm, maternal genomes are hypomethylated compared with the paternal genome.
epigenetic reprogramming in the endosperm
Isoenergetic transfer of an Atg8 family modifier from one protein to a phosphatidylethanolamine or phosphatidylserine on a membrane, via the reaction X-Atg8 + Y = Y-Atg8 + X.
APG8 conjugating enzyme activity
Atg8 conjugating enzyme activity
Atg8-like conjugating activity
E2
A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to a lipid, where it acts as a marker for a membrane, recognized by the cellular apparatus to target the tagged protein for some cellular process such as autophagy.
covalent modifier
lipid tag
Catalysis of the reaction: glutathionylated protein (PSSG) + glutathione (GSH) = protein-thiol (PSH) + glutathione disulfide (GSSG). The reaction may proceed via a 'monothiol' or 'dithiol' mechanism.
glutaredoxin activity
glutathione oxidoreductase activity
Any process in which a symbiont interferes with a host antimicrobial peptide, for example by cleavage or degradation.
disruption of host antimicrobial peptide activity
A process that contributes to the onset of de novo transcription from the zygotic genome as part of the maternal-to-zygote transition in gene expression. The zygote overcomes the silencing that has been established. The cause of this silencing could be due to several factors: chromatin modifications leading to repression, or lack of adequate transcription machinery.
ZGA
The chemical reactions and pathways resulting in the clearance of maternal mRNA transcripts from the zygote as part of the maternal-to-zygote transition in gene expression.
maternal mRNA degradation
maternal transcript clearance
maternal transcript degradation
The process in which an organism effects a change that impairs the structure or function of the host extracellular matrix.
disruption of host extracellular matrix
The establishment of epigenetic modifications (imprints) in autosomal (non-sexual) chromosomes during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation.
autosomal genomic imprinting
genomic imprinting of autosomal genes
Binds to and decreases the activity of the ligand of a signaling receptor.
signaling receptor ligand inhibitor activity
A process in which a symbiont interferes with, inhibits or disrupts a MAPK signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
disruption of host MAP kinase signaling pathway
disruption of host MAPK signal transduction pathway
disruption of host MAPK signaling pathway
symbiont-mediated suppression of host MAPK signal transduction pathway
A process in which a symbiont subverts a MAPK signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction.
activation by symbiont of host MAPK signal transduction pathway
induction by symbiont of host MAP kinase signal transduction pathway
induction of host MAPK kinase signaling pathway
stimulation by symbiont of host MAPK signal transduction pathway
symbiont-mediated activation of host MAPK signal transduction pathway
A process in which a virus interferes with, inhibits or disrupts a tumor necrosis factor-mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
disruption of host TNF-mediated signaling pathway
disruption of host TNFR-mediated signaling pathway
disruption of host tumor necrosis factor receptor-mediated signaling pathway
disruption of host tumor necrosis factor-mediated signaling pathway
A process in which a symbiont alters or subverts opsonization by the host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
disruption by symbiont of host opsonization
A process in which a virus interferes with, inhibits or disrupt a cGAS/STING signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
disruption of host cGAS-STING signal transduction
disruption of host cGAS-STING signaling
suppression of host cGAS-STING
A process in which a symbiont subverts an inflammasome-mediated signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction.
perturbation of host inflammasome-mediated signal transduction
A process in which a symbiont interferes with, inhibits or stops an inflammasome-mediated signal transduction pathway in the host organism by interfering with its normal execution. The host is defined as the larger of the organisms involved in a symbiotic interaction.
perturbation of host inflammasome-mediated signal transduction
A process in which a symbiont interferes with, inhibits or disrupts the host signal transduction pathways leading to the production of reactive oxygen species as part of the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
inhibition by organism of defense-related host active oxygen species production
Binding to and responding, e.g. by conformational change, to changes in the cellular level of glucose.
glucose sensing activity
Catalysis of the reaction: protein phospho-serine + inositol 5-triphosphate pentakisphosphate = protein diphospho-serine + inositol 5-diphosphate pentakisphosphate.
protein serine pyrophosphatase activity
Catalysis of the reaction: cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H+ + S-adenosyl-L-homocysteine.
tRNA (cytidine 34-2\'-O)-methyltransferase activity
Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 18 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 18 in tRNA + H+.
tRNA (guanosine(18)-2\'-O)-methyltransferase activity
Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + uridine44 in tRNASer = 2'-O-methyluridine44 in tRNASer + H+ + S-adenosyl-L-homocysteine.
tRNA(Ser) (uracil(44)-2\'-O-)-methyltransferase activity
Catalysis of the reaction: 5-carboxymethylaminomethyluridine34 in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNA(Leu) + H+ + S-adenosyl-L-homocysteine.
tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2\'-O)- methyltransferase activity
A process by which a symbiont disrupts or prematurely activates host complement so that its microbial-destroying activities fail.
suppression of complement activation by another organism by inactivation of complement proteins
A process by which a symbiont prevents host complement activation by sequestering it away from its surface.
suppression of complement activation by another organism by complement sequestering
A process by which a symbiont prevents the activation of host complement by binding a soluble complement control protein (CCP) of the host and recruiting it to the microbe surface. The normal role of CCPs is to prevent complement activation on 'self' cellular targets. When soluble CCPs are recuited to the surface of a microbe, the complement fails to activate.
suppression of complement activation by another organism by recruitment of complement control protein
suppression of complement activation by another organism by recuitement of complement control protein
The process that maintains methylated cytosine in newly synthesized DNA following DNA replication. After the establishment of novel DNA methylation marks, the newly created patterns must be faithfully transmitted by maintenance DNA methyltransferases during cell division.
DNA methylation
DNA methylation maintenance
DNA methylation maintenance following cell division
DNA methylation maintenance following DNA replication
genome methylation maintenance following DNA replication
Catalysis of the reaction: queuosine34 in tRNA + UDP-alpha-D-galactose = H+ + O-5''-beta-D-galactosylqueuosine34 in tRNATyr + UDP. Substrates include tRNA(Tyr) and tRNA(Asp).
tRNA queuosine galactosyltransferase activity
tRNA queuosine(34) galactosyltransferase activity
A process in which a symbiont alters a Rab protein family-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
modulation by symbiont of host Rab protein mediated signal transduction
modulation by symbiont of host Rab protein signal transduction
modulation by symbiont of host Rab protein-mediated signal transduction
modulation of host Rab protein signal transduction by symbiont
modulation of host Rab protein signaling by symbiont
modulation of host Rab protein signalling by symbiont
perturbation of host Rab protein signal transduction
symbiont-mediated perturbation of host Rab protein signal transduction
A process by which a symbiont superantigen elicits a strong immune response by activating a large number of T cells in a non-specific manner. Unlike conventional antigens, which activate T cells by interacting with specific receptors on the surface of these cells, superantigens can stimulate T cells by binding to regions outside the antigen-binding site. Superantigens can activate a large proportion of T cells, leading to an exaggerated immune response. This excessive activation can result in the release of a large amount of cytokines such as tumor necrosis factor and interleukin-2. The massive cytokine release can lead to an acute toxic shock, causing symptoms such as fever and organ damage.
symbiont-mediated non-specific T-cell activation in host
symbiont-mediated nonspecific activation of host T-cells
A process by which a symbiont alters or subverts a host cell surface receptor-mediated signal transduction pathway by binding to and inhibiting the receptor of the pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated perturbation of host signal transduction pathway via antagonism of host cell surface receptor
A process in which a symbiont inhibits or disrupts translation of mRNA into protein in its host by inactivating its ribosomes.
symbiont-mediated host ribosome inactivation
Catalysis of the reaction: 2-oxoglutarate + an N6-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate.
DNA N(6)-methyladenine demethylase activity
A process in which a symbiont subverts a signal transduction pathway in the host organism by binding to and enhancing the activation of the receptor of the pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated perturbation of host signal transduction pathway via antagonism of host cell surface receptor
A process in which a symbiont interferes with, inhibits or disrupts the normal execution of the immunoglobulin-mediated immune response of the host organism. One common mechanism by which this happens is the direct inhibition of immunoglobulin activity, by direct binding or modification. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated suppression of host immunoglobulin activity
A process by which a symbiont avoids recognition by host's innate immune response by altering or concealing a conserved molecule recognized by the host's cell surface and intracellular pattern recognition receptors, including Toll-like and NOD-like receptors. The host is defined as the larger of the organisms involved in a symbiotic interaction.
evasion of symbiont recognition by host pattern recognition receptor
A process in which a symbiont damages or impairs host neutrophil extracellular traps. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated perturbation of host neutrophil extracellular traps