NothingMuch/GO-Terms huggingface dataset:
The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex.
motogenic signalling initiating cell movement in the cerebral cortex
The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.
neuronal-glial interaction involved in cerebral cortex glial-mediated radial migration
The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration.
cell locomotion involved in cerebral cortex glial-mediated radial migration
cell locomotion involved in cerebral cortex radial glia guided migration
Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration.
modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration
The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.
cerebral cortex lamination
The process in which neurons interact with each other to promote migration along a tangential plane.
chain migration
The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially.
neuroblast division in the ventral telencephalon
The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron.
projection neuron differentiation
The progression of a pyramidal neuron from its initial formation to its mature state.
projection neuron development
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
radial glial cell differentiation in forebrain
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate.
abventricular progenitor cell differentiation
intermediate progenitor cell differentiation
non-surface dividing progenitor cell differentiation
The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons.
generation of neurons in forebrain
The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter.
hypothalamus gonadotropin-releasing hormone neuron differentiation
The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell.
hypothalamus gonadotropin-releasing hormone neuron development
The process in which the neural tube is divided into specific regions along the rostrocaudal axis.
anterior-posterior neural tube patterning
The process in which the neural tube is regionalized in the dorsoventral axis.
dorsal-ventral neural tube patterning
dorsoventral neural tube patterning
The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
hedgehog signaling pathway involved in ventral spinal cord patterning
hh signaling pathway involved in ventral spinal cord patterning
smoothened signalling pathway in ventral spinal cord patterning
The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration.
hindbrain neurophilic migration
The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation.
Purkinje cell-granule cell precursor cell signalling involved in regulation of granule cell precursor cell proliferation
The process that activates or increases the rate or extent of granule cell precursor proliferation.
activation of granule cell precursor proliferation
stimulation of granule cell precursor proliferation
up regulation of granule cell precursor proliferation
up-regulation of granule cell precursor proliferation
upregulation of granule cell precursor proliferation
The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation.
down regulation of granule cell precursor proliferation
down-regulation of granule cell precursor proliferation
downregulation of granule cell precursor proliferation
inhibition of granule cell precursor proliferation
The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells.
Bergmann fiber biosynthesis
Bergmann fiber formation
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
central nervous system axon tract development
Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.
corticospinal tract axonogenesis
CST axonogenesis
The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues.
corticospinal neuron axon pathfinding
The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.
hypophysis development
The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.
adenophysis development
anterior pituitary development
anterior pituitary gland development
The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation.
neurophysis development
posterior pituitary development
posterior pituitary gland development
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
corticogenesis
neocortex development
The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.
neural plate anterior/posterior pattern formation
Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate.
caudalization of neural plate
down regulation of anterior neural cell fate of the neural plate
down-regulation of anterior neural cell fate of the neural plate
downregulation of anterior neural cell fate of the neural plate
inhibition of anterior neural cell fate of the neural plate
negative regulation of anterior neural cell fate of the neural plate
posteriorization
Generation of cells within the nervous system.
nervous system cell generation  systematic_synonym
neural cell differentiation
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
myelination in central nervous system
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
peripheral nervous system myelination
The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.
rostral migratory stream migration
Any process that modulates the frequency, rate or extent of opsin-mediated signaling.
regulation of rhodopsin mediated signaling pathway
regulation of rhodopsin mediated signalling
regulation of rhodopsin-mediated signaling pathway
The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
negative adaptation of signal transduction pathway
negative adaptation of signalling pathway
Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.
down regulation of cell-cell adhesion
down-regulation of cell-cell adhesion
downregulation of cell-cell adhesion
inhibition of cell-cell adhesion
Any process that activates or increases the rate or extent of cell adhesion to another cell.
activation of cell-cell adhesion
stimulation of cell-cell adhesion
up regulation of cell-cell adhesion
up-regulation of cell-cell adhesion
upregulation of cell-cell adhesion
A cellular process that results in the breakdown of a cellular component.
cell structure disassembly
cellular component disassembly at cellular level
A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism.
reproductive cellular process in multicellular organism
A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
single organism reproductive process
The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.
bristle development
A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.
estrous cycle process
menstrual cycle process
Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.
regulation of morphogenesis
Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.
negative regulation of cell shape and cell size
positive regulation of cell shape and cell size
regulation of cell shape and cell size
A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell.
mammalian oogenesis process
The aggregation, arrangement and bonding together of a cellular component.
cell structure assembly
cellular component assembly at cellular level
A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated.
multicellular organism dormancy process
spore dormancy process
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex.
ribonucleoprotein complex biogenesis and assembly
RNA-protein complex biogenesis
The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere.
protein-membrane docking
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.
ribonucleoprotein complex assembly
RNA-protein complex assembly
RNP complex assembly
A ribosome located in the cytosol.
70S ribosome
80S ribosome
Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged.
facilitated diffusion
porters
uniporter activity z
Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.
active carrier activity
carrier activity
permease activity
pump activity
Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.
porter
Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
potassium ion antiporter activity
Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts.
ionotropic neurotransmitter receptor activity
transmitter-gated ion channel activity
Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.
gap junction activity
non-gated, wide pore channel activity
Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts.
extracellular substance gated channel activity
neurotransmitter-gated channel activity
Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus.
ion gated channel activity
monoatomic ion gated channel activity
Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated cation channel activity
Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction.
active ion transmembrane transporter activity
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
substrate-specific transmembrane transporter activity
substrate-specific transporter activity
uptake permease activity
uptake transmembrane transporter activity
Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane.
zinc efflux permease activity
Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
di-, tri-valent inorganic cation transmembrane transporter activity
divalent inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
trivalent inorganic cation transmembrane transporter activity
A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
6-phosphofructokinase reduction
dihydrobiopterin reduction
dihydrolipoamide reduction
dihydrolipoylprotein reduction
dihydropteridine reduction
electron transfer
other pathways of electron transport
oxidized glutathione reduction
protein-disulfide reduction
The series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.
CD40 signalling pathway
Any process that modulates the frequency, rate or extent of a signaling process.
regulation of signaling process
regulation of signalling process
The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
biological signaling
signaling process
signalling
signalling process
single organism signaling
Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.
positive regulation of signaling process
positive regulation of signalling process
Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.
negative regulation of signaling process
negative regulation of signalling process
The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
adaptation of signalling pathway
The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.
signal secretion
The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
divalent metal ion export
divalent metal ion transport
heavy metal ion transport
metal ion export
A homeostatic process involved in the maintenance of a steady state level of monoatomic anions within a cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom.
cellular anion homeostasis
cellular monoatomic anion homeostasis
A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom.
cellular cation homeostasis
cellular monoatomic cation homeostasis
A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active.
transport protein particle
transport protein particle complex
TRAPP1
TRAPP2
The specification and formation of anisotropic intracellular organization or cell growth patterns.
bud site selection/establishment of cell polarity
cell polarization
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
Z band
Z disk
Z line
A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.
core extracellular matrix
core matrisome
A homeostatic process involved in the maintenance of a steady state level of manganese ions within a cell.
cellular manganese ion homeostasis
manganese homeostasis
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
microfilament-based process
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
cell projection organisation
cell projection organization and biogenesis
cell surface structure organization and biogenesis
Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
cell projection biogenesis
formation of a cell surface projection
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
lamellipodium biogenesis
lamellipodium biosynthesis
lamellipodium formation
Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.
microvillus biogenesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
actin cytoskeleton organisation
actin cytoskeleton organization and biogenesis
actin modulating activity
Assembly of actin filaments by the addition of actin monomers to a filament.
actin polymerization
actin polymerizing activity
Disassembly of actin filaments by the removal of actin monomers from a filament.
actin depolymerization
actin depolymerizing activity
A cell junction that forms a connection between a cell and the extracellular matrix.
cell-matrix junction
A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
macula adherens
spot desmosome
Catalysis of the reaction: an aliphatic amine + an acceptor (A) + H2O = an aldehyde + a reduced acceptor (AH2) + NH4+.
amine dehydrogenase activity
amine: (acceptor) oxidoreductase (deaminating)
MADH activity
methylamine dehydrogenase activity
primary-amine dehydrogenase activity
primary-amine:acceptor oxidoreductase (deaminating)
A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria.
plasma membrane-derived thylakoid
A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center.
antenna complex
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
blood cell biosynthesis
blood cell formation
haemopoiesis
hematopoiesis
The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
lymphocyte cell differentiation
lymphocyte development
lymphocytic blood cell differentiation
The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
NK cell activation