NothingMuch/GO-Terms huggingface dataset:
A process mediated by a molecule secreted by a symbiont that results in the suppression of reactive oxygen species produced by the host as part of its innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
down regulation by organism of defense-related host metabolic burst
down-regulation by organism of defense-related host oxidative burst
downregulation by organism of defense-related host AOS production
negative regulation by organism of defense-related host reactive oxidative species production
negative regulation by organism of defense-related host reactive oxygen intermediate production
negative regulation by organism of defense-related host respiratory burst
negative regulation by organism of defense-related host ROI production
negative regulation by organism of defense-related host ROS production
negative regulation by symbiont of defense-related host reactive oxygen species production
suppression by symbiont of defense-related host reactive oxygen species production
A process in which a symbiont inhibits or disrupts the normal execution of host apoptosis, leading to a decrease in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
down regulation by organism of host apoptotic programmed cell death
down-regulation by organism of host apoptotic programmed cell death
downregulation by organism of host apoptotic programmed cell death
inhibition by organism of host apoptotic programmed cell death
negative regulation by symbiont of host apoptosis
negative regulation by symbiont of host apoptotic process
negative regulation by virus of host apoptosis
suppression by symbiont of host apoptotic process
suppression by virus of host apoptosis
Any process that modulates the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule.
NAD kinase regulator
regulation of NAD kinase activity
Unwinding of a DNA/RNA duplex in the 5' to 3' direction, driven by ATP hydrolysis.
5\' to 3\' DNA/RNA helicase activity
ATP-dependent 5\' to 3\' DNA/RNA helicase activity
ATP-dependent 5\'-3\' DNA/RNA helicase activity
Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis.
3\' to 5\' DNA/RNA helicase activity
ATP-dependent 3\' to 5\' DNA/RNA helicase activity
ATP-dependent 3\'-5\' DNA/RNA helicase activity
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone.
down regulation of luteinizing hormone secretion
down-regulation of luteinizing hormone secretion
downregulation of luteinizing hormone secretion
inhibition of luteinizing hormone secretion
Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone.
activation of luteinizing hormone secretion
stimulation of luteinizing hormone secretion
up regulation of luteinizing hormone secretion
up-regulation of luteinizing hormone secretion
upregulation of luteinizing hormone secretion
Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation.
down regulation of osteoblast proliferation
down-regulation of osteoblast proliferation
downregulation of osteoblast proliferation
inhibition of osteoblast proliferation
Any process that activates or increases the rate or extent of osteoblast proliferation.
activation of osteoblast proliferation
stimulation of osteoblast proliferation
up regulation of osteoblast proliferation
up-regulation of osteoblast proliferation
upregulation of osteoblast proliferation
Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.
N-acetylneuraminic acid binding
The assembly of neurofilaments into bundles, in which the filaments are longitudinally oriented, with numerous crossbridges between them. Neurofilament bundles may be cross-linked to each other, to membrane-bounded organelles or other cytoskeletal structures such as microtubules.
NF bundle assembly
A process that forms a boundary that limits the spreading of heterochromatin along a chromosome.
maintenance of heterochromatin boundaries
negative regulation of extent of heterochromatin assembly
negative regulation of extent of heterochromatin formation
negative regulation of heterochromatin spreading
regulation of extent of heterochromatin assembly
regulation of extent of heterochromatin formation
regulation of heterochromatin spreading
A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a two copies of catalytic histone deacetylase subunit (S. pombe Clr6/ S. cerevisiae Rpd3p), an Sds-3 family protein (S. pombe /S. cerevisiae Sds3(p) ), two copies of SIN3 family co-repressor (S. pombe Pst1/ S. cerevisiae Sin3p, a WD repeat protein/ histone chaperone (S. pombe Prw1/ S. cerevisiae Ume1p), and a zf- PHD finger ( S. pombe Png2/ S. cerevisiae Pho23p), plus 4 additional subunits, and associated factors.
Clr6 histone deacetylase complex I/I\'
Clr6L complex
Rpd3C(L)
Sin3L complex
Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus.
AMP-removal activity
DNA 5\'-adenylate hydrolase activity
DNA adenylate hydrolysis activity
DNA de-adenylation
DNA deadenylation
Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+.
dTDP-D-galactose:NADP+ 6-oxidoreductase activity
dTDPgalactose 6-dehydrogenase activity
thymidine-diphosphate-galactose dehydrogenase activity
Catalysis of the reaction: (1R,5S)-carveol + NAD+ = (S)-carvone + H+ + NADH.
(+)-trans-carveol:NAD+ oxidoreductase activity
Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + H+ + NADPH.
3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity
3beta-hydroxysteroid 5beta-oxidoreductase activity
3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity
Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5alpha-pregnane-3,20-dione + H+ + NADPH.
3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity
Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+.
GDP-4-keto-6-deoxy-D-mannose reductase activity
GDP-6-deoxy-D-lyxo-4-hexulose reductase activity
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity
Rmd
Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+.
2\'-deoxymugineic acid:NAD(P)+ 3\'\'-oxidoreductase activity
Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+.
homoisocitrate-isocitrate dehydrogenase activity
isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity
PH1722
Catalysis of the reaction: D-arabinitol + NADP+ = D-ribulose + NADPH + H+. Can also produce D-ribulose.
ARD1p
D-arabinitol dehydrogenase 1 activity
D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity
D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
D-arabinitol:NADP+ dehydrogenase activity
NADP+-dependent D-arabinitol dehydrogenase activity
Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H+ + NADH.
4-O-phosphoerythronate dehydrogenase activity
4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity
4PE dehydrogenase activity
erythronate-4-phosphate dehydrogenase activity
PdxB
PdxB 4PE dehydrogenase activity
Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH.
1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity
AFR
Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide.
choline oxidase activity
Catalysis of the reaction: secondary alcohol + O2 = H2O2 + ketone.
polyvinyl alcohol oxidase activity
secondary alcohol oxidase activity
secondary-alcohol:oxygen oxidoreductase activity
Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O.
nucleoside:oxygen 5\'-oxidoreductase activity
Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide.
nucleoside:oxygen 5\'-oxidoreductase (hydrogen peroxide-forming) activity
Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor.
2-ketogluconate reductase activity
D-gluconate dehydrogenase activity
D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity
D-gluconate:(acceptor) 2-oxidoreductase activity
D-gluconate:acceptor 2-oxidoreductase activity
gluconate oxidase activity
gluconic acid dehydrogenase activity
gluconic dehydrogenase activity
Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor, and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor.
PDH
pyranose dehydrogenase activity
pyranose-quinone oxidoreductase activity
pyranose:acceptor oxidoreductase activity
quinone-dependent pyranose dehydrogenase activity
Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor.
(2R)-hydroxy-carboxylate:acceptor oxidoreductase activity
(2R)-hydroxycarboxylate-viologen-oxidoreductase activity
2-oxoacid reductase activity
HVOR
Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor.
(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity
L(+)-mandelate dehydrogenase activity
MDH
Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+.
3-oxopropanoate:NAD(P)+ oxidoreductase activity
malonic semialdehyde dehydrogenase activity
Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+.
fluoroacetaldehyde:NAD+ oxidoreductase activity
Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin.
aldehyde:ferredoxin oxidoreductase activity
AOR
tungsten-containing aldehyde ferredoxin oxidoreductase activity
Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor.
aldehyde oxidoreductase activity
aldehyde:acceptor oxidoreductase (FAD-independent) activity
AORDd
Mop
Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+.
4VCR
chlorophyllide a reductase activity
chlorophyllide-a:NADP+ oxidoreductase activity
Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+.
ANR
AtANR
flavan-3-ol:NAD(P)+ oxidoreductase activity
MtANR
Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2.
arogenic dehydrogenase activity
L-arogenate:NADP+ oxidoreductase (decarboxylating) activity
pretyrosine dehydrogenase activity
TyrAa
TyrAAT1
TyrAAT2
Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 2 H2O + 2 H2O2 + H+ + pyrroloquinoline quinone.
6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity
PqqC
Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein.
(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity
(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity
BbsG
Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+.
aspartate dehydrogenase NAD activity
aspartate dehydrogenase NADP activity
L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity
NAD-dependent aspartate dehydrogenase activity
NADH2-dependent aspartate dehydrogenase activity
NADP+-dependent aspartate dehydrogenase activity
Catalysis of the reaction: H2O + L-lysine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + NH4+.
L-lysine-epsilon-oxidase activity
L-lysine:oxygen 6-oxidoreductase (deaminating) activity
Lod
LodA
marinocine
Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin.
5,10-methylenetetrahydrofolate reductase activity
5-methyltetrahydrofolate:ferredoxin oxidoreductase activity
Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 3 H+ + 2 NADPH.
7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity  systematic_synonym
7-cyano-7-deazaguanine reductase activity
preQ0 oxidoreductase activity
preQ0 reductase activity
QueF
queuine synthase activity
queuine:NADP+ oxidoreductase activity
YkvM
Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor.
hydroxylamine:acceptor oxidoreductase activity
Catalysis of the reaction: AMP + glutathione disulfide + H+ + sulfite = 5'-adenylyl sulfate + 2 glutathione.
5\'-adenylylsulfate reductase activity
AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5\'-phosphosulfate-forming) activity
AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5\'-phosphosulfate-forming) activity
plant-type 5\'-adenylylsulfate reductase activity
Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
methionine S-oxide reductase (R-form oxidizing) activity
methionine S-oxide reductase activity
methionine sulfoxide reductase activity
methionine sulfoxide reductase B activity
MsrB
peptide-methionine:thioredoxin-disulfide S-oxidoreductase  activity
PilB
pMRsr
pMSR
protein-methionine-R-oxide reductase activity
selenoprotein R
SelR
SelX
Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin.
free met-R-(o) reductase activity
free-methionine (R)-S-oxide reductase activity
FRMsr
L-methionine:thioredoxin-disulfide S-oxidoreductase  activity
methionine-R-sulfoxide reductase activity
Catalysis of the removal of the methyl group from a modified arginine residue at position 2 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
histone demethylase activity (H3-R2 specific)
histone H3-methyl-arginine-2 demethylase activity
histone H3-R2 demethylase activity
histone H3R2me demethylase activity
Catalysis of the reaction: H2 + A = AH2.
H2 producing hydrogenase activity
hydrogen-lyase activity
hydrogen:(acceptor) oxidoreductase activity
hydrogen:acceptor oxidoreductase activity
hydrogenlyase activity
uptake hydrogenase activity
Catalysis of the removal of the methyl group from a modified arginine residue at position 3 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
histone demethylase activity (H4-R3 specific)
histone H4-methyl-arginine-3 demethylase activity
histone H4R3me demethylase activity
Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal.
acetylacetone dioxygenase activity
acetylacetone-cleaving enzyme
acetylacetone:oxygen oxidoreductase activity
diketone cleaving dioxygenase activity
diketone cleaving enzyme
Dke1
Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine.
D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity
IDO
tryptophan pyrrolase activity
Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+.
SOR
sulfur oxygenase activity
sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity
sulphur oxygenase/reductase activity
Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu.
Oplophorus luciferase activity
Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity
Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor.
D-aldohexopyranoside dehydrogenase
D-aldohexoside:(acceptor) 3-oxidoreductase
D-aldohexoside:acceptor 3-oxidoreductase
D-aldohexoside:cytochrome c oxidoreductase
hexopyranoside-cytochrome c oxidoreductase
Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O.
clavaminate synthase 2 activity
clavaminic acid synthase activity
deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O.
flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity
flavone synthase I activity
FNS I
Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + H+ + mugineate + succinate.
2\'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity
IDS3
Catalysis of the reaction: mugineate + 2-oxoglutarate + O2 = 3-epihydroxymugineate + CO2 + H+ + succinate. Also converts 2'-deoxymugineate to 3-epihydroxy-2'-deoxymugineate.
IDS2
mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2.
L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
P-3-H
Catalysis of the reaction: H+ + NADH + O2 + quinolin-2-ol = H2O + NAD+ + quinoline-2,8-diol.
2-oxo-1,2-dihydroquinoline 8-monooxygenase activity
quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity
Catalysis of the reaction: 4'-hydroxyacetophenone + H+ + NADPH + O2 = 4-hydroxyphenyl acetate + H2O + NADP+.
(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity  systematic_synonym
HAPMO
Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin II or glyceollin III + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin I + NADP+ + 2 H2O.
dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity
Catalysis of the reactions: liquiritigenin + O2 +  = 2,4',7-trihydroxyisoflavanone + H2O +  and (2S)-naringenin + O2 +  = 2,4',5,7-tetrahydroxyisoflavanone + H2O + .
isoflavonoid synthase
Catalysis of the reaction: a flavanone + O2 + reduced  = a 2-hydroxyflavanone + H+ + H2O + oxidized .
licodione synthase activity
Catalysis of the reaction: a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced  = a 3',5'-dihydroxyflavanone + 2 H+ + 2 H2O + 2 oxidized .
F3\',5\'H
F3\'5\'H
flavanone,NADPH:oxygen oxidoreductase activity
Catalysis of the reaction: an isoflavone + O2 + reduced  = a 2'-hydroxyisoflavone + H+ + H2O + oxidized .
CYP Ge-3
CYP81E1
isoflavone 2\'-monooxygenase activity
Catalysis of the reaction: 10-deoxysarpagine + H+ + NADPH + O2 = H2O + NADP+ + sarpagine.
10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity
DOSH
Catalysis of the reaction: H+ + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP+.
PAMO
phenylacetone,NADPH:oxygen oxidoreductase activity
Catalysis of the reaction: H+ + lithocholate + NADPH + O2 = 6-beta-hydroxylithocholate + H2O + NADP+.
6beta-hydroxylase activity
CYP3A10
cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity
lithocholate 6beta-monooxygenase activity
lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity
Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H+ + NADPH + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP+.
7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity
Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H+ + NADPH + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H2O + NADP+.
5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity
5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity
Catalysis of the reaction: taurochenodeoxycholate + O2 + reduced  +  = taurohyocholate H+ + H2O + oxidized . Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate.
CYP3A4
CYP4A21
taurochenodeoxycholate 6alpha-monooxygenase activity
taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity
Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+.
cholesterol 24-monooxygenase activity
cholesterol 24S-hydroxylase activity
cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity
CYP46
CYP46A1
cytochrome P450 46A1
Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced  = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized .
24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity
24-hydroxycholesterol 7alpha-monooxygenase activity
Catalysis of the reactions: 25-hydroxycholesterol + O2 + reduced  = 7alpha,25-dihydroxycholesterol + H+ + H2O + oxidized . Also converts (25R)-cholest-5-ene-3beta,26-diol to (25R)-cholest-5-en-3beta,7alpha,26-triol.
25-hydroxycholesterol 7alpha-monooxygenase activity
cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity
CYP7B1
CYP7B1 oxysterol 7alpha-hydroxylase activity
Catalysis of the reaction: H+ + NADPH + O2 + senecionine = H2O + NADP+ + senecionine N-oxide.
senecionine monooxygenase (N-oxide-forming) activity
senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity
SNO
Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP.
D-alpha,beta-D-heptose 7-phosphate 1-kinase activity
Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose.
D-beta-D-heptose 1-phosphate adenylyltransferase activity
heptose 1-phosphate adenyltransferase activity
Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP+ = cyanocob(III)alamin + H+ + NADPH.
cob(I)alamin, cyanide:NADP+ oxidoreductase activity
cyanocobalamin reductase (NADPH, cyanide-eliminating) activity
cyanocobalamin reductase (NADPH; CN-eliminating) activity
cyanocobalamin reductase activity
NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity
NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity
Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+.
(2R,3S)-catechin:NADP+ 4-oxidoreductase activity
leucocyanidin reductase activity
Catalysis of the reaction: 2 1,4-benzoquinone + H2O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA.
phenylacetyl-CoA:acceptor oxidoreductase activity
phenylacetyl-CoA:quinone oxidoreductase activity
Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor.
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity
THC-CoA oxidase activity
THCA-CoA oxidase activity
trihydroxycoprostanoyl-CoA oxidase activity
Catalysis of the reactions: a 3alpha-hydroxy bile acid CoA + NAD+ = a 3-oxo bile acid CoA + H+ + NADH.
7alpha-dehydroxylase activity
bile acid 7-dehydroxylase activity
bile-acid 7alpha-dehydroxylase activity
cholate 7alpha-dehydroxylase activity