NothingMuch/GO-Terms huggingface dataset:
Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid.
isoleucine/valine:sodium symporter activity
L-valine transporter activity
leucine/isoleucine/valine porter activity
leucine/valine/isoleucine permease activity
valine/tyrosine/tryptophan permease activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).
sodium/choline symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in).
sodium/chloride-dependent creatine transporter
Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high-affinity glutamate transmembrane transporter activity
high-affinity glutamate transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction:phosphate(out) + Na+(out) = phosphate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high affinity inorganic phosphate:sodium symporter activity
high-affinity inorganic phosphate:sodium symporter activity
sodium/phosphate cotransporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in).
sodium/neurotransmitter symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in).
dopamine transmembrane transporter activity
dopamine:sodium:chloride symporter activity
sodium/dopamine symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in).
4-aminobutanoate:sodium symporter activity
4-aminobutyrate:sodium symporter activity
betaine/GABA:sodium symporter activity
GABA:sodium symporter activity
gamma-aminobutyric acid:sodium symporter activity
sodium/chloride-dependent GABA transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in).
levarterenol transporter activity
noradrenaline transporter activity
norepinephrine transmembrane transporter activity
norepinephrine:sodium:chloride symporter activity
sodium/norepinephrine symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in).
serotonin transmembrane transporter activity
serotonin:sodium symporter activity
sodium/serotonin symporter activity
Enables the transfer of nucleotide-sulfate from one side of a membrane to the other.
nucleotide-sulphate transporter activity
Binding to oxygen and delivering it to an acceptor molecule or a specific location.
globin
hemerythrin
hemocyanin
oxygen-carrying
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.
alpha-glucoside:hydrogen symporter activity
general alpha-glucoside transporter activity
general alpha-glucoside:hydrogen symporter activity
general alpha-glucoside:proton symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high-affinity glucose:proton symporter activity
high-affinity hydrogen/glucose transporter activity
high-affinity hydrogen:glucose symporter activity
high-affinity hydrogen:glucose transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
low-affinity glucose:proton symporter activity
low-affinity hydrogen/glucose transporter activity
low-affinity hydrogen:glucose symporter activity
low-affinity hydrogen:glucose transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
insulin-responsive glucose:proton symporter activity
insulin-responsive hydrogen:glucose symporter activity
insulin-responsive hydrogen:glucose transporter activity
transepithelial hydrogen/glucose transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose(out) + Na+(out) = D-glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.
low-affinity glucose-sodium cotransporter activity
low-affinity glucose:sodium symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in).
hydrogen/maltose transporter activity
maltose permease
maltose:hydrogen symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in).
hydrogen/myo-inositol transporter activity
myo-inositol:hydrogen symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in).
myo-inositol-sodium cotransporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in).
sodium/chloride-dependent taurine transporter
Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement.
hydrogen/oligopeptide symporter
proton-dependent oligopeptide transporter activity
Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other.
CMP-sialic acid transmembrane transporter activity
Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out).
adenine nucleotide translocase
ADP/ATP carrier protein
ADP/ATP translocase
ATP/ADP exchange
ATP/ADP exchanger
Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial).
carnitine/acyl carnitine carrier activity
carnitine:acyl carnitine carrier activity
fatty acyl carnitine carrier
Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
pyruvate carrier activity
Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex.
SNAP
Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
Q-SNARE activity
R-SNARE activity
SNAP-25
SNARE
t-SNARE activity
v-SNARE activity
Binding to 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A.
11-cis retinaldehyde binding
11-cis-retinal binding
vitamin A binding
Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A.
all-trans retinaldehyde binding
trans retinal binding
visual yellow binding
vitamin A binding
xanthopsin
The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.
Ca2+ ion detection
calcium ion detection
calcium ion sensing
detection of Ca2+ ion
Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope.
lamin/chromatin binding
Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Mg-ATP binding
MgATP binding
Binding to a 23-membered macrolide lactone FK506.
FK506-sensitive peptidyl-prolyl cis-trans isomerase
Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides.
galactose binding lectin
Binding to D-enantiomers of glucose.
glucose binding
Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans.
mannose binding
mannose binding lectin
Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
hyaluronan binding
Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
folate binding
vitamin B9 binding
vitamin M binding
Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding
phosphatidylinositol 4,5-bisphosphate binding
PIP2 binding
PtdIns(4,5)P2 binding
Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
PIP3 binding
A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.
fibrinogen
fibrinogen alpha chain
fibrinogen beta chain
fibrinogen gamma chain
A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
MAC
membrane attack complex protein alphaM chain
membrane attack complex protein beta2 chain
TCC
terminal complement complex
A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains.
complement component C1q complex
A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.
laminin-111 complex
A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains.
laminin-211 complex
A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains.
laminin-121 complex
A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains.
laminin-221 complex
A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains.
laminin-332 complex
laminin-3A32 complex
laminin-5A complex
A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains.
laminin-311 complex
laminin-6A complex
A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains.
laminin-321 complex
laminin-7A
Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins.
ascus lipid particle
Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C.
type V intermediate filament
The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide.
nuclear intermembrane space
nuclear membrane lumen
perinuclear space
A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.
nucleolar RNase P complex
A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.
eukaryotic pre-replicative complex
pre-RC
pre-replicative complex
A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a small stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.
DNA polymerase alpha:primase complex
heterotetrameric polymerase alpha holoenzyme
pol-prim
primosome
A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.
replication protein A
RPA
A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
eukaryotic ORC
nuclear ORC
RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
DNA-directed RNA polymerase II, core complex
RNA polymerase II complex
RNAP II complex
RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
DNA-directed RNA polymerase III activity
DNA-directed RNA polymerase III complex
A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.
selectivity factor SL1 complex
TIF-IB
A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
anaphase promoting complex
APC
cyclosome
A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes.
snRNP U5
A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs.
snRNP U7
A ribonucleoprotein complex that contains small nuclear RNA U1, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U1 snRNP, most of which remain associated with the U1 snRNA both while the U1 snRNP is free or assembled into a series of spliceosomal complexes.
snRNP U1
A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes.
17S U2 snRNP
snRNP U2
A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes.
snRNP U4
A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes.
snRNP U6
A ribonucleoprotein complex that contains small nuclear RNA U4atac, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4atac snRNP, most of which remain associated with the U4atac snRNA both while the U4atac snRNP is free or assembled into the U4atac/U6atac complex or into a series of spliceosomal complexes.
snRNP U4atac
A ribonucleoprotein complex that contains small nuclear RNA U6atac, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6atac snRNP, most of which remain associated with the U6atac snRNA both while the U6atac snRNP is free or assembled into the U4atac/U6atac snRNP or into a series of spliceosomal complexes.
snRNP U6atac
A ribonucleoprotein complex that contains small nuclear RNA U11, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U11 snRNP, most of which remain associated with the U11 snRNA both while the U11 snRNP is free or assembled into a series of spliceosomal complexes.
12S U11 snRNP
snRNP U11
A ribonucleoprotein complex that contains small nuclear RNA U12, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U12 snRNP, most of which remain associated with the U12 snRNA both while the U12 snRNP is free or assembled into a series of spliceosomal complexes.
snRNP U12
A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization.
constriction
A thread-like connection joining two regions of ectopically paired polytene chromosomes.
polytene chromosome ectopic fibre
Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats.
extrachromosomal ribosomal DNA circle
A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed.
NOR
nucleolus organiser region
nucleolus organizer complex
RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
DNA-directed RNA polymerase I activity
DNA-directed RNA polymerase I complex
A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D).
mitochondrial PT pore complex
MPTP complex
PTPC
The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
39S ribosomal subunit, mitochondrial
The smaller of the two subunits of a mitochondrial ribosome.
28S ribosomal subunit, mitochondrial
mitochondrial ribosomal small subunit complex
mitochondrial ribosomal SSU complex
The component of the intraperoxisomal membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic to intraperoxisomal membrane
intra-peroxisomal peripheral membrane
A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events.
Sec61p-Sbh1p-Sss1p complex
A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex.
docking protein complex
SR complex