NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: D-glucose 6-sulfate + H2O = D-glucose + H+ + sulfate.
glucosulfatase activity
glycosulphatase activity
sugar-sulfate sulfohydrolase activity
Catalysis of the reaction: glycyrrhizate + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate.
glycyrrhizin beta-hydrolase activity
glycyrrhizin hydrolase activity
glycyrrhizinate b-glucuronidase activity
glycyrrhizinate glucuronosylhydrolase activity
glycyrrhizinic acid hydrolase activity
Catalysis of the reaction: CoA + glyoxylate + NADP+ = H+ + NADPH + oxalyl-CoA.
glyoxylate:NADP+ oxidoreductase (CoA-oxalylating)
Catalysis of the reaction: glyoxylate + H2O + O2 = H2O2 + H+ + oxalate.
glyoxylate:oxygen oxidoreductase activity
Catalysis of the reaction: guanidinoacetate + H2O = glycine + urea.
glycocyaminase activity
guanidinoacetate amidinohydrolase activity
Catalysis of the reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea.
4-guanidinobutanoate amidinohydrolase activity
4-guanidinobutyrate amidinobutyrase activity
G-base activity
gamma-guanidinobutyrate amidinohydrolase activity
gamma-guanidobutyrase activity
GBH
guanidinobutyrate ureahydrolase activity
Catalysis of the reaction: 3-guanidinopropanoate + H2O = beta-alanine + urea.
3-guanidinopropanoate amidinopropionase activity
GPase activity
GPH
Catalysis of the reaction: ATP + guanidinoacetate = ADP + 2 H+ + phosphoguanidinoacetate.
ATP:guanidinoacetate N-phosphotransferase activity
glycocyamine kinase activity
guanidoacetate kinase activity
Catalysis of the reaction: guanosine + H2O = xanthosine + NH3.
guanosine aminase activity
guanosine aminohydrolase activity
Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate.
guanosine:phosphate alpha-D-ribosyltransferase activity
guanosine:phosphate D-ribosyltransferase activity
Catalysis of the reaction: D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + 2 H+.
ATP/hamamelose 2\'-phosphotransferase activity
ATP:D-hamamelose 2\'-phosphotransferase activity
hamamelose kinase (phosphorylating)
hamamelosekinase (ATP: hamamelose 2\'-phosphotransferase)
Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate.
(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity
hepoxilin A(3) hydrolase activity
hepoxilin A3 hydrolase activity
hepoxilin epoxide hydrolase activity
hepoxylin hydrolase activity
Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH.
hexadecanol dehydrogenase activity
hexadecanol:NAD+ oxidoreductase activity
Catalysis of the reaction: N-benzoylglycine + H2O = benzoate + glycine.
benzoylglycine amidohydrolase activity
hippuricase activity
N-benzoylamino-acid amidohydrolase activity
Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H+.
acetyl-CoA:L-histidine N-acetyltransferase activity
acetylhistidine synthetase activity
histidine acetyltransferase activity
Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate.
homocysteine desulfurase activity
L-homocysteine hydrogen-sulfide-lyase (deaminating)
L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)
Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H+ + phosphate.
beta-alanine specific hGSH synthetase activity
gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)
homoglutathione synthetase activity
Catalysis of the reaction: H2 + NAD+ = H+ + NADH.
bidirectional hydrogenase activity
H(2):NAD(+) oxidoreductase activity
H2:NAD+ oxidoreductase activity
hydrogen:NAD+ oxidoreductase activity
hydrogenase activity
NAD-linked hydrogenase activity
Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate.
acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity
hydrogen-sulfide acetyltransferase activity
hydrogen-sulphide S-acetyltransferase activity
Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate.
(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity
transhydrogenase, hydroxy acid-oxo acid
Catalysis of the reaction: (R)-3-butanoate + H2O = 2 (R)-3-hydroxybutanoate + H+.
(R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity
D-(-)-3-hydroxybutyrate-dimer hydrolase activity
Catalysis of the reaction: 3-hydroxy-L-glutamate + H+ = 4-amino-3-hydroxybutanoate + CO2.
3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming)
3-hydroxy-L-glutamate 1-carboxy-lyase activity
Catalysis of the reaction: hydroxylamine + O2 = H2O + H+ + nitrite.
HAO
hydroxylamine oxidoreductase
hydroxylamine:oxygen oxidoreductase activity
Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H+.
GTP:5-hydroxy-L-lysine O-phosphotransferase activity
guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity
hydroxylysine kinase (phosphorylating)
Catalysis of the reaction: hydroxymalonate + NAD+ = H+ + NADH + oxomalonate.
hydroxymalonate:NAD+ oxidoreductase activity
Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H+.
(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity
3-hydroxy-3-methylglutaryl-CoA hydrolase activity
beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity
beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity
hydroxymethylglutaryl coenzyme A deacylase activity
hydroxymethylglutaryl coenzyme A hydrolase activity
Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH.
4-hydroxyphenyllactate:NAD+ oxidoreductase activity
HPRP
Catalysis of the reaction: (2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2.
L-2-hydroxyphytanate:oxygen 2-oxidoreductase
Catalysis of the reaction: 3-hydroxypyruvate + H+ = CO2 + glycolaldehyde.
hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)
hydroxypyruvate carboxy-lyase activity
Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate.
hyoscyamine (6S)-hydroxylase activity
hyoscyamine 6-beta-hydroxylase activity
hyoscyamine 6-hydroxylase activity
hyoscyamine 6beta-dioxygenase activity
hyoscyamine 6beta-hydroxylase activity
L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)
Catalysis of the reaction: 2 hydroxylamine + 2 NAD+ = 2 H+ + hyponitrous acid + 2 NADH.
hydroxylamine:NAD+ oxidoreductase activity
NADH2:hyponitrite oxidoreductase activity
NADH:hyponitrite oxidoreductase activity
Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O.
formononetin,NADPH:oxygen oxidoreductase (3\'-hydroxylating)
isoflavone 3\'-monooxygenase activity
Catalysis of the reaction: D-erythrose 4-phosphate + H2O + NAD+ = 4-phospho-D-erythronate + 2 H+ + NADH.
D-erythrose 4-phosphate:NAD+ oxidoreductase activity
E4P dehydrogenase activity
E4PDH
Epd dehydrogenase activity
erythrose 4-phosphate dehydrogenase activity
GapB
The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
antigen presentation, endogenous lipid antigen
endogenous lipid antigen processing and presentation via MHC class Ib
The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
antigen presentation, exogenous peptide antigen
exogenous lipid antigen processing and presentation via MHC class Ib
The series of molecular signals initiated by an angiopoietin binding to the Tie receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
angiopoietin-Tie signaling pathway
angiopoietin/Tie signaling pathway
Tek receptor signaling
Tie receptor signaling pathway
Tie receptor signalling pathway
The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
inositol phospholipid-mediated signaling
phosphatidylinositol-mediated signal transduction
phosphatidylinositol-mediated signalling
phosphoinositide-mediated signaling
phosphoinositide-mediated signalling
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
down regulation of melanin biosynthetic process
down-regulation of melanin biosynthetic process
downregulation of melanin biosynthetic process
inhibition of melanin biosynthetic process
negative regulation of melanin anabolism
negative regulation of melanin biosynthesis
negative regulation of melanin formation
negative regulation of melanin synthesis
Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
activation of melanin biosynthetic process
positive regulation of melanin anabolism
positive regulation of melanin biosynthesis
positive regulation of melanin formation
positive regulation of melanin synthesis
stimulation of melanin biosynthetic process
up regulation of melanin biosynthetic process
up-regulation of melanin biosynthetic process
upregulation of melanin biosynthetic process
Binding to an mRNA molecule at its 5' untranslated region.
mRNA 5\' UTR binding
Binding to a galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group.
galacturonic acid binding
The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle.
haem O biosynthesis
haem O biosynthetic process
heme O anabolism
heme O biosynthesis
heme O formation
heme O synthesis
The chemical reactions and pathways resulting in the breakdown of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle.
haem O catabolic process
haem O catabolism
heme O breakdown
heme O catabolism
heme O degradation
The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli.
central body development
Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose.
UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)
UDP-D-glucuronate carboxy-lyase activity
UDP-glucuronic acid decarboxylase activity
UDPglucuronate decarboxylase activity
uridine-diphosphoglucuronate decarboxylase activity
The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner.
mating behaviour, sex discrimination
The directed movement of a motile cell or organism away from the source of gravity.
negative geotactic behavior
negative geotactic behaviour
negative gravitactic behavior
negative gravitactic behaviour
negative taxis in response to gravity
negative taxis in response to gravitytaxis in response to gravitational stimulus
The directed movement of a motile cell or organism towards the source of gravity.
positive geotactic behavior
positive geotactic behaviour
positive gravitactic behavior
positive gravitactic behaviour
positive taxis in response to gravity
positive taxis in response to gravitytaxis in response to gravitational stimulus
Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the compound eye.
down regulation of eye pigmentation
down-regulation of eye pigmentation
downregulation of eye pigmentation
inhibition of eye pigmentation
negative regulation of eye pigmentation
Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye.
activation of eye pigmentation
positive regulation of eye pigmentation
stimulation of eye pigmentation
up regulation of eye pigmentation
up-regulation of eye pigmentation
upregulation of eye pigmentation
Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism.
down regulation of adult chitin-containing cuticle pigmentation
down-regulation of adult chitin-containing cuticle pigmentation
downregulation of adult chitin-containing cuticle pigmentation
inhibition of adult chitin-containing cuticle pigmentation
Any process that activates or increases the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism.
activation of adult chitin-containing cuticle pigmentation
stimulation of adult chitin-containing cuticle pigmentation
up regulation of adult chitin-containing cuticle pigmentation
up-regulation of adult chitin-containing cuticle pigmentation
upregulation of adult chitin-containing cuticle pigmentation
Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in females.
down regulation of female pigmentation
down-regulation of female pigmentation
downregulation of female pigmentation
inhibition of female pigmentation
Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females.
activation of female pigmentation
stimulation of female pigmentation
up regulation of female pigmentation
up-regulation of female pigmentation
upregulation of female pigmentation
Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in males.
down regulation of male pigmentation
down-regulation of male pigmentation
downregulation of male pigmentation
inhibition of male pigmentation
Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males.
activation of male pigmentation
stimulation of male pigmentation
up regulation of male pigmentation
up-regulation of male pigmentation
upregulation of male pigmentation
Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin.
calcium- and calmodulin-regulated 3\',5\'-cyclic-GMP phosphodiesterase activity
calcium- and calmodulin-regulated cGMP phosphodiesterase activity
calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity
calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity
calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity
Orientation along the body surface of bristles, sensory organs originating from a sensory organ precursor cell, such that they all point in a uniform direction.
establishment of body bristle planar orientation
The chemical reactions and pathways resulting in the formation of 4-amino-3-isothiazolinone, five-membered saturated heterocyclic ring structures containing a sulfur and a nitrogen in the 1-position and 2-positions respectively.
4-amino-3-isothiazolidinone anabolism
4-amino-3-isothiazolidinone biosynthesis
4-amino-3-isothiazolidinone formation
4-amino-3-isothiazolidinone synthesis
The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.
female germ-line stem cell renewal
Formation of a group of interconnected cells derived from a single male gonial founder cell.
male germline cyst formation
The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids.
spermatocyte cell division
The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster.
germarium-derived cystoblast cell division
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
behavioural response to cocaine
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
behavioural response to ethanol
Any process that results in a change in the behavior of an organism as a result of an ether stimulus.
behavioural response to ether
The stage in mammalian oogenesis when the primordial germ cell is hardly distinguishable from other cortical cells of the ovary.
mammalian oogenesis stage 1
The stage in oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells.
mammalian oogenesis stage 2
The stage in oogenesis when the antrum is swollen with follicular fluid. The ovum is ready to erupt from the ovary and is arrested at metaphase of the second meiotic division.
mammalian oogenesis stage 9
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
activation of long-term neuronal synaptic plasticity
stimulation of long-term neuronal synaptic plasticity
up regulation of long-term neuronal synaptic plasticity
up-regulation of long-term neuronal synaptic plasticity
upregulation of long-term neuronal synaptic plasticity
A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
down regulation of long-term neuronal synaptic plasticity
down-regulation of long-term neuronal synaptic plasticity
downregulation of long-term neuronal synaptic plasticity
inhibition of long-term neuronal synaptic plasticity
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
activation of short-term neuronal synaptic plasticity
stimulation of short-term neuronal synaptic plasticity
up regulation of short-term neuronal synaptic plasticity
up-regulation of short-term neuronal synaptic plasticity
upregulation of short-term neuronal synaptic plasticity
A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
down regulation of short-term neuronal synaptic plasticity
down-regulation of short-term neuronal synaptic plasticity
downregulation of short-term neuronal synaptic plasticity
inhibition of short-term neuronal synaptic plasticity
A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B.
inhibin beta-A
inhibin beta-B
A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.
COMPASS complex
Set1/COMPASS complex
Set1C
The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing.
wing disc dorsal-ventral pattern formation
wing disc dorsoventral pattern formation
The aggregation, arrangement and bonding together of a set of components to form a membrane priming complex. An incoming coat component recognizes both GTPase and a membrane protein to form the priming complex.
formation of dictyosome membrane priming complex
formation of Golgi membrane priming complex
The aggregation, arrangement and bonding together of priming complexes to form a coat on a Golgi membrane. Priming complexes associate laterally and additional coat proteins are recruited from the cytosol to the forming coat. Cargo proteins diffuse into the budding site and become trapped by their interactions with the coat.
dictyosome membrane binding by cytosolic coat proteins
dictyosome membrane bud coat oligomerisation
Golgi apparatus membrane coat protein complex assembly
Golgi membrane bud coat oligomerisation
The process in which cytosolic coat proteins fit together in a basketlike convex framework to form a coated deformed region on the cytoplasmic surface of the membrane. The deformed region forms into a complete vesicle and is released.
dictyosome vesicle bud deformation
Golgi-derived vesicle bud deformation and release
Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus.
regulation of Golgi vesicle targeting
The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane.
dictyosome vesicle docking to target membrane
Golgi vesicle docking with target membrane
Golgi vesicle to membrane docking
Golgi-derived vesicle docking
The process in which Golgi vesicle coat proteins are depolymerized, and released for reuse.
dictyosome vesicle coat depolymerization
Golgi vesicle coat depolymerization
Golgi vesicle coat protein depolymerization
Golgi-derived vesicle uncoating
Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane.
activation of Golgi vesicle fusion to target membrane
stimulation of Golgi vesicle fusion to target membrane
up regulation of Golgi vesicle fusion to target membrane
up-regulation of Golgi vesicle fusion to target membrane
upregulation of Golgi vesicle fusion to target membrane
Any process that stops, prevents, or reduces the frequency, rate or extent of Golgi vesicle fusion to target membrane.
down regulation of Golgi vesicle fusion to target membrane
down-regulation of Golgi vesicle fusion to target membrane
downregulation of Golgi vesicle fusion to target membrane
inhibition of Golgi vesicle fusion to target membrane
An extracellular matrix part that consists of cross-linked glycoproteins.
extensin
The process in which a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte.
male gamete generation
male gametophyte sperm cell differentiation
sperm cell differentiation
The volume enclosed by the membranes of the rough endoplasmic reticulum.
RER lumen
rough ER lumen
The volume enclosed by the membranes of the smooth endoplasmic reticulum.
SER lumen
smooth ER lumen
Catalysis of the reaction: 2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate.
phytanoyl-CoA 2 oxoglutarate dioxygenase activity
phytanoyl-CoA 2-hydroxylase activity
phytanoyl-CoA alpha-hydroxylase activity
phytanoyl-CoA hydroxylase activity
phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)
Enables the transfer of phosphate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high affinity phosphate transmembrane transporter activity
The process in which iron is transported from the cytosol into the mitochondrial matrix.
mitochondrial iron cation transmembrane transport
mitochondrial iron ion transmembrane transport
mitochondrial iron ion transport
mitochondrial iron transport