NothingMuch/GO-Terms huggingface dataset:
The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system.
cellular component morphogenesis
cellular structure morphogenesis
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
macromolecular complex
macromolecule complex
protein complex
protein containing complex
protein-protein complex
A macromolecular complex containing both protein and DNA molecules.
DNA-protein complex
Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin.
regulation of chitin- and beta-glucan-containing cell wall biogenesis
A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin.
Fc-receptor complex
FcR complex
immunoglobulin receptor complex
The expansion of a muscle cell population by cell division.
myocyte proliferation
Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response.
regulation of mast cell activation during immune response
The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
tetrapyrrole metabolism
The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
tetrapyrrole anabolism
tetrapyrrole biosynthesis
tetrapyrrole formation
tetrapyrrole synthesis
The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
tetrapyrrole breakdown
tetrapyrrole catabolism
tetrapyrrole degradation
The chemical reactions and pathways involving cyclopentanol.
cyclopentanol metabolism
Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.
apoptosis of mast cells
mast cell apoptosis
Any process that modulates the frequency, rate, or extent of mast cell apoptotic process.
regulation of mast cell apoptosis
Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.
apoptosis of myeloid cells
myeloid cell apoptosis
Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process.
regulation of neutrophil apoptosis
Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process.
regulation of myeloid cell apoptosis
Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process.
down regulation of myeloid cell apoptosis
down-regulation of myeloid cell apoptosis
downregulation of myeloid cell apoptosis
inhibition of myeloid cell apoptosis
negative regulation of myeloid cell apoptosis
Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.
activation of myeloid cell apoptosis
positive regulation of myeloid cell apoptosis
stimulation of myeloid cell apoptosis
up regulation of myeloid cell apoptosis
up-regulation of myeloid cell apoptosis
upregulation of myeloid cell apoptosis
Any process in which a macromolecule is transported to, or maintained in, a specific location.
macromolecule localisation
Any process in which a polysaccharide is transported to, or maintained in, a specific location.
polysaccharide localisation
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
regulation of organelle organisation
regulation of organelle organization and biogenesis
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.
regulation of chromosome organisation
regulation of chromosome organization and biogenesis
The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicycloheptane-2-carboxylic acid.
clavulanic acid metabolism
The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group.
cyanoamino acid metabolism
The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria.
macrolide metabolism
The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria.
macrolide anabolism
macrolide biosynthesis
macrolide formation
macrolide synthesis
The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity.
ansamycin metabolism
The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44--3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)oxadiazacyclohexadecinobenzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria.
vancomycin metabolism
The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclohept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicycloheptane.
pinene metabolism
The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclohept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicycloheptane.
pinene breakdown
pinene catabolism
pinene degradation
The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin.
ipecac alkaloid biosynthesis
isoquinoline alkaloid anabolism
isoquinoline alkaloid biosynthesis
isoquinoline alkaloid formation
isoquinoline alkaloid synthesis
The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin.
ipecac alkaloid metabolism
isoquinoline alkaloid metabolism
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
T cell development in thymus
thymic T cell differentiation
thymocyte cell differentiation
thymocyte differentiation
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus.
extrathymic T cell development
The expansion of an immature T cell population by cell division in the thymus.
thymic T cell proliferation
thymocyte cell proliferation
thymocyte proliferation
Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus.
regulation of T cell development in thymus
regulation of thymic T cell differentiation
regulation of thymocyte cell differentiation
regulation of thymocyte differentiation
Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation.
regulation of extrathymic T cell development
Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus.
regulation of thymic T cell proliferation
regulation of thymocyte cell proliferation
regulation of thymocyte proliferation
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus.
negative regulation of T cell development in thymus
negative regulation of thymic T cell differentiation
negative regulation of thymocyte cell differentiation
negative regulation of thymocyte differentiation
Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus.
positive regulation of T cell development in thymus
positive regulation of thymic T cell differentiation
positive regulation of thymocyte cell differentiation
positive regulation of thymocyte differentiation
A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes.
aleurone body
The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network.
cis Golgi network membrane
Golgi cis face membrane
A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p).
cytoplasm to vacuole targeting vesicle
cytoplasm-to-vacuole targeting vesicle
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.
regulation of purine nucleotide breakdown
regulation of purine nucleotide catabolism
regulation of purine nucleotide degradation
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.
negative regulation of purine nucleotide breakdown
negative regulation of purine nucleotide catabolism
negative regulation of purine nucleotide degradation
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.
positive regulation of purine nucleotide breakdown
positive regulation of purine nucleotide catabolism
positive regulation of purine nucleotide degradation
Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.
glucokinase regulator
Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
regulation of serine phosphorylation of STAT3 protein
Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.
regulation of steroid hormone receptor signaling pathway
regulation of steroid hormone receptor signalling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.
negative regulation of steroid hormone receptor signaling pathway
negative regulation of steroid hormone receptor signalling pathway
Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.
positive regulation of steroid hormone receptor signaling pathway
positive regulation of steroid hormone receptor signalling pathway
Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
regulation of estrogen receptor signaling pathway
regulation of estrogen receptor signalling pathway
The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
V(D)J joining
V-D-J joining
V-D-J recombination
V-J joining
V-J recombination
The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined.
immunoglobulin V(D)J joining
immunoglobulin V-D-J joining
immunoglobulin V-D-J recombination
immunoglobulin V-J joining
immunoglobulin V-J recombination
Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage.
GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity
GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity
GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase activity
glycolipid 6-alpha-mannosyltransferase activity
initiation-specific alpha-1,6-mannosyltransferase activity
Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).
calcineurin-NFAT signaling pathway
calcineurin-NFAT signalling pathway
A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.
hydrogen-translocating V-type ATPase complex
A proton-transporting two-sector ATPase complex found in the plasma membrane.
plasma membrane hydrogen ion-transporting ATPase
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.
response to retinol
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus.
response to DL-alpha-tocopherol acetate
response to DL-alpha-tocopheryl acetate
response to O-Acetyl-alpha-tocopherol
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
response to adenosine 5\'-triphosphate
response to adenosine triphosphate
A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells.
cytokinesis after meiosis
Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage.
beta-1,4-GalNAc transferase activity
The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
adipocytokine signaling pathway
TNF-alpha-mediated signaling pathway
tumor necrosis factor alpha-mediated signaling pathway
tumor necrosis factor-mediated signalling pathway
The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
adipocytokine signaling pathway
leptin-mediated signalling pathway
The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.
ferrous ion import
ferrous iron import
ferrous iron uptake
iron assimilation
A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors.
iron assimilation by capture and transport
iron assimilation by chelation and transport
iron chelate transport
Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein.
regulation of sumoylation
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines.
regulation of amine metabolism
regulation of cellular amine metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines.
negative regulation of amine metabolism
negative regulation of cellular amine metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines.
positive regulation of amine metabolism
positive regulation of cellular amine metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines.
regulation of amine breakdown
regulation of amine catabolism
regulation of amine degradation
regulation of cellular amine catabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines.
negative regulation of amine breakdown
negative regulation of amine catabolism
negative regulation of amine degradation
negative regulation of cellular amine catabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines.
positive regulation of amine breakdown
positive regulation of amine catabolism
positive regulation of amine degradation
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
regulation of penicillin metabolism
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
negative regulation of penicillin metabolism
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
positive regulation of penicillin metabolism
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
regulation of penicillin breakdown
regulation of penicillin catabolism
regulation of penicillin degradation
The chemical reactions and pathways involving plastid DNA.
plastid DNA metabolism
The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.
DNA replication during S phase
DNA replication involved in S phase
DNA replication involved in S-phase
nuclear cell cycle DNA replication
Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.
regulation of DNA replication during S phase
regulation of DNA replication involved in S phase
regulation of DNA replication involved in S-phase
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus.
response to riboflavin
The sliding movement of actin thin filaments and myosin thick filaments past each other.
actin filament sliding
The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.
cell proliferation in mesencephalon
mesencepahalic cell proliferation
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.
response to calciferol
response to cholecalciferol
response to ergocalciferol
Enables the transfer of an organic acid from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out).
ATP-dependent organic acid transmembrane transporter activity
organic acid-transporting ATPase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out).
ATP-dependent carboxylic acid transporter activity
carboxylic acid-transporting ATPase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out).
ATP-dependent monocarboxylic acid transmembrane transporter activity
monocarboxylic acid-transporting ATPase activity
The chemical reactions and pathways involving O-glucosylated derivatives of quercetin.
quercetin O-glucoside metabolism
The chemical reactions and pathways involving chlorophyll a.
chlorophyll a metabolism
The chemical reactions and pathways leading to the formation of chlorophyll a.
chlorophyll a anabolism
chlorophyll a biosynthesis
chlorophyll a formation
chlorophyll a synthesis
The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol.
phytol metabolism
A signaling process that contributes to a meiotic cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
meiotic cell cycle checkpoint
signal transduction involved in meiotic cell cycle checkpoint