NothingMuch/GO-Terms huggingface dataset:
The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination.
DNA ligation during DNA recombination
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.
down regulation of DNA ligation
down-regulation of DNA ligation
downregulation of DNA ligation
inhibition of DNA ligation
Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA.
carnitine synthetase activity
crotonobetaine/carnitine-CoA ligase activity
Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA.
crotonobetaine-CoA synthase activity
crotonobetaine/carnitine-CoA ligase activity
Catalysis of the reaction: ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H+ + phosphate.
CobN-CobST
CobNST
hydrogenobyrinic acid a,c-diamide cobaltochelatase activity
hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)
Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran.
1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity
cariogenanase activity
cariogenase activity
endo-(1->3)-alpha-glucanase activity
endo-1,3-alpha-D-glucanase activity
endo-1,3-alpha-glucanase activity
mutanase activity
The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology.
hepoxilin anabolism
hepoxilin biosynthesis
hepoxilin formation
hepoxilin synthesis
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell differentiation.
down regulation of NK T cell differentiation
down-regulation of NK T cell differentiation
downregulation of NK T cell differentiation
inhibition of NK T cell differentiation
negative regulation of natural killer T cell differentiation
negative regulation of natural T cell differentiation
negative regulation of NK T cell development
negative regulation of NK T lymphocyte differentiation
negative regulation of NK T-cell differentiation
negative regulation of NK T-lymphocyte differentiation
negative regulation of NKT cell differentiation
negative regulation of NT cell differentiation
Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation.
activation of NK T cell differentiation
positive regulation of natural killer T cell differentiation
positive regulation of natural T cell differentiation
positive regulation of NK T cell development
positive regulation of NK T lymphocyte differentiation
positive regulation of NK T-cell differentiation
positive regulation of NK T-lymphocyte differentiation
positive regulation of NKT cell differentiation
positive regulation of NT cell differentiation
stimulation of NK T cell differentiation
up regulation of NK T cell differentiation
up-regulation of NK T cell differentiation
upregulation of NK T cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation.
down regulation of NK T cell proliferation
down-regulation of NK T cell proliferation
downregulation of NK T cell proliferation
inhibition of NK T cell proliferation
negative regulation of natural killer T cell proliferation
negative regulation of natural T cell proliferation
negative regulation of NK T lymphocyte proliferation
negative regulation of NK T-cell proliferation
negative regulation of NK T-lymphocyte proliferation
negative regulation of NKT cell proliferation
negative regulation of NT cell proliferation
Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation.
activation of NK T cell proliferation
positive regulation of natural killer T cell proliferation
positive regulation of natural T cell proliferation
positive regulation of NK T lymphocyte proliferation
positive regulation of NK T-cell proliferation
positive regulation of NK T-lymphocyte proliferation
positive regulation of NKT cell proliferation
positive regulation of NT cell proliferation
stimulation of NK T cell proliferation
up regulation of NK T cell proliferation
up-regulation of NK T cell proliferation
upregulation of NK T cell proliferation
The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein.
coenzyme and prosthetic group catabolic process
coenzyme and prosthetic group catabolism
prosthetic group breakdown
prosthetic group catabolism
prosthetic group degradation
The chemical reactions and pathways involving silicates, the salts of silicic acids. Silicates are usually composed of silicon and oxygen (SiO), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates.
silicate metabolism
The process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth.
uniform cell growth
The process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell.
non-isotropic cell growth
Binding to a vanadium ion (V).
V ion binding
An RNAi-mediated post-transcriptional gene silencing pathway induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or inhibition of translation. In plants, DCL4 is the primary Dicer to detect RNA viruses.
RNA VIGS
RNA virus induced gene silencing
RNA virus-induced gene silencing
RNA virus-induced PTGS
An RNAi-mediated post-transcriptional gene silencing pathway induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or inhibition of translation. In plants, DCL3 is the primary Dicer to detect DNA viruses.
DNA VIGS
DNA virus induced gene silencing
DNA virus-induced gene silencing
DNA virus-induced PTGS
The controlled breakdown of the spindle during a meiotic cell cycle.
meiotic spindle breakdown
meiotic spindle catabolism
meiotic spindle degradation
spindle breakdown during meiosis
spindle degradation during meiosis
spindle disassembly during meiosis
Any process that stops, prevents, or reduces the rate of the cellular defense response.
down regulation of cellular defense response
down-regulation of cellular defense response
downregulation of cellular defense response
inhibition of cellular defense response
negative regulation of cellular defence response
The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis.
meiotic spindle midzone biogenesis
meiotic spindle midzone biosynthesis
meiotic spindle midzone formation
spindle midzone assembly involved in meiosis
spindle midzone biogenesis involved in meiosis
spindle midzone biosynthesis involved in meiosis
spindle midzone formation involved in meiosis
Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol.
acyl-CoA-independent mono-olein transacylation
MOG transacylation
mono-oleoylglycerol O-acyltransferase activity
mono-oleoylglycerol transacylase activity
monoolein transacylation
monooleoylglycerol O-acyltransferase activity
monooleoylglycerol transacylase activity
Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein.
acyl-CoA-independent diolein transacylation
dioleoylglycerol O-acyltransferase activity
dioleoylglycerol transacylase activity
DOG transacylation
Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin.
siroheme ferro-lyase (sirohydrochlorin-forming)
siroheme synthase activity
sirohydrochlorin ferro-lyase activity
Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-phosphate-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2.
addition of ethanolamine phosphate to mannose of GPI precursor CP2
CP2 ethanolamine phosphate transferase activity
CP2 EtN-P transferase activity
CP2 phosphoethanolamine transferase activity
gpi7 activity
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
protein heterotetramer assembly
protein heterotetramer biosynthesis
protein heterotetramer biosynthetic process
protein heterotetramer formation
Any process that set the alignment of meiotic spindle relative to other cellular structures.
establishment of spindle orientation during meiosis
establishment of spindle orientation involved in meiotic cell cycle
meiotic spindle orientation
orienting of meiotic spindle
The process in which paired chromosomes are physically detached from each other during male meiosis.
chromosome separation during male meiosis
male meiosis chromosome resolution
The process in which paired chromosomes are physically detached from each other during female meiosis.
chromosome separation during female meiosis
female meiosis chromosome resolution
The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis.
G1 phase of meiotic cell cycle
The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis.
G2 phase of meiotic cell cycle
The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle.
premeiotic S-phase
S phase of meiotic cell cycle
S-phase of meiotic cell cycle
The reformation of the nuclear membranes during meiosis I.
meiosis I nuclear envelope reassembly
The reformation of the nuclear membrane during meiosis II.
meiosis II nuclear envelope reassembly
Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation.
direct nuclear division
Remak nuclear division
Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
3\',5\' cyclic nucleotide phosphodiesterase activator
3\',5\'-cyclic-AMP phosphodiesterase activator
activation of cyclic nucleotide phosphodiesterase activity
cAMP phosphodiesterase activator
phosphodiesterase activator
positive regulation of 3\',5\' cyclic nucleotide phosphodiesterase activity
positive regulation of 3\',5\'-cyclic-AMP phosphodiesterase activity
positive regulation of cAMP phosphodiesterase activity
positive regulation of cGMP phosphodiesterase activity
positive regulation of cyclic nucleotide phosphodiesterase activity
stimulation of cyclic nucleotide phosphodiesterase activity
up regulation of cyclic nucleotide phosphodiesterase activity
up-regulation of cyclic nucleotide phosphodiesterase activity
upregulation of cyclic nucleotide phosphodiesterase activity
Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
3\',5\' cyclic nucleotide phosphodiesterase inhibitor
3\',5\'-cyclic-AMP phosphodiesterase inhibitor
cAMP phosphodiesterase inhibitor
down regulation of cyclic nucleotide phosphodiesterase activity
down-regulation of cyclic nucleotide phosphodiesterase activity
downregulation of cyclic nucleotide phosphodiesterase activity
inhibition of cyclic nucleotide phosphodiesterase activity
negative regulation of 3\',5\' cyclic nucleotide phosphodiesterase activity
negative regulation of 3\',5\'-cyclic-AMP phosphodiesterase activity
negative regulation of cAMP phosphodiesterase activity
negative regulation of cGMP phosphodiesterase activity
negative regulation of cyclic nucleotide phosphodiesterase activity
phosphodiesterase inhibitor
Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.
down regulation of ligase activity
down-regulation of ligase activity
downregulation of ligase activity
inhibition of ligase activity
ligase inhibitor
The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity.
equilibrioception by proprioception
perception of orientation with respect to gravity by proprioception
proprioception during equilibrioception
The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity.
equilibrioception by visual perception
perception of orientation with respect to gravity by visual perception
visual perception during equilibrioception
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions.
cellular response to K+ ion deprivation
cellular response to K+ ion starvation
cellular response to potassium ion deprivation
cellular response to potassium starvation
The modification of a protein amino acid by formation of an ester or amide with decanoic acid.
protein amino acid decanoylation
Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.
alpha-actinin 2 binding
alpha-actinin 3 binding
Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components.
calsarcin 1 binding
calsarcin 2 binding
calsarcin 3 binding
calsarcin binding
FATZ 1 binding
FATZ 2 binding
FATZ 3 binding
filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle
Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
5-hydroxytryptamine binding
Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.
adrenaline binding
Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
noradrenaline binding
Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.
down regulation of nerve growth factor receptor signaling pathway
down-regulation of nerve growth factor receptor signaling pathway
downregulation of nerve growth factor receptor signaling pathway
inhibition of nerve growth factor receptor signaling pathway
negative regulation of nerve growth factor receptor signaling pathway
negative regulation of nerve growth factor receptor signalling pathway
negative regulation of NGF receptor signaling pathway
negative regulation of NGF receptor signalling pathway
Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.
activation of nerve growth factor receptor signaling pathway
positive regulation of nerve growth factor receptor signaling pathway
positive regulation of nerve growth factor receptor signalling pathway
positive regulation of NGF receptor signaling pathway
positive regulation of NGF receptor signalling pathway
stimulation of nerve growth factor receptor signaling pathway
up regulation of nerve growth factor receptor signaling pathway
up-regulation of nerve growth factor receptor signaling pathway
upregulation of nerve growth factor receptor signaling pathway
Catalysis of the reaction: a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N4-acetylcytidine in tRNA + CoA + H+ + phosphate.
tRNA cytidine N-acetyltransferase activity
Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor.
regulation of NGF receptor activity
Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins.
calponin homology domain binding
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out).
dihydroxyacetone-phosphate:inorganic phosphate antiporter activity
glycerone phosphate:inorganic phosphate antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out).
glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity
The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation.
IMTOC-mediated microtubule nucleation during interphase
interphase microtubule nucleation by interphase microtubule organising centre
interphase microtubule nucleation by interphase microtubule organizing center
interphase microtubule organizing center-mediated microtubule nucleation during interphase
microtubule nucleation during interphase by IMTOC
microtubule nucleation during interphase by interphase microtubule organizing center
The 'de novo' formation of a microtubule, mediated by the spindle pole body.
microtubule nucleation by SPB
SPB-mediated microtubule nucleation
spindle pole body-mediated microtubule nucleation
Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.
corticoliberin binding
corticotropin-releasing factor binding
CRF binding
CRH binding
Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain.
phosphotyrosine-interacting domain binding
PID binding
Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.
CRHR1 binding
type 1 corticotropin releasing factor receptor binding
type 1 corticotropin releasing factor receptor ligand
type 1 corticotropin-releasing factor receptor binding
Binding to a corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery.
CRHR2 binding
type 2 corticotropin releasing factor receptor binding
type 2 corticotropin releasing factor receptor ligand
type 2 corticotropin-releasing factor receptor binding
Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
GnRH binding
gonadotrophin releasing hormone binding
Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system.
thyrotropin releasing hormone binding
The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs.
attachment of meiotic spindle microtubules to kinetochore in meiosis II
attachment of spindle microtubules to kinetochore during meiosis II
meiotic bipolar attachment
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell.
down regulation of adrenocorticotropin secretion
down-regulation of adrenocorticotropin secretion
downregulation of adrenocorticotropin secretion
inhibition of adrenocorticotropin secretion
negative regulation of ACTH secretion
negative regulation of adrenocorticotropic hormone secretion
negative regulation of adrenocorticotropin secretion
negative regulation of adrenotropic hormone secretion
negative regulation of adrenotropin secretion
negative regulation of corticotropic hormone secretion
Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell.
activation of adrenocorticotropin secretion
positive regulation of ACTH secretion
positive regulation of adrenocorticotropic hormone secretion
positive regulation of adrenocorticotropin secretion
positive regulation of adrenotropic hormone secretion
positive regulation of adrenotropin secretion
positive regulation of corticotropic hormone secretion
stimulation of adrenocorticotropin secretion
up regulation of adrenocorticotropin secretion
up-regulation of adrenocorticotropin secretion
upregulation of adrenocorticotropin secretion
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell.
down regulation of cortisol secretion
down-regulation of cortisol secretion
downregulation of cortisol secretion
inhibition of cortisol secretion
Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell.
activation of cortisol secretion
stimulation of cortisol secretion
up regulation of cortisol secretion
up-regulation of cortisol secretion
upregulation of cortisol secretion
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell.
down regulation of corticotropin-releasing hormone secretion
down-regulation of corticotropin-releasing hormone secretion
downregulation of corticotropin-releasing hormone secretion
inhibition of corticotropin-releasing hormone secretion
negative regulation of corticotropin-releasing factor secretion
negative regulation of CRF secretion
negative regulation of CRH secretion
Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell.
activation of corticotropin-releasing hormone secretion
positive regulation of corticotropin-releasing factor secretion
positive regulation of CRF secretion
positive regulation of CRH secretion
stimulation of corticotropin-releasing hormone secretion
up regulation of corticotropin-releasing hormone secretion
up-regulation of corticotropin-releasing hormone secretion
upregulation of corticotropin-releasing hormone secretion