Extraction schema:
{"type": "object", "title": "Real-content CSR expired carbon monoxide listing extraction schema", "description": "Extract listing metadata and every expired-CO measurement row from a clinical study report appendix listing. Rows are grouped by subject: the subject number and study product are printed only on the first row of each group and must be carried forward to its continuation rows. '---' cells mean not measured (null); times 'ND'/'UNK' are kept as printed per the page note.", "required": ["cro_study_number", "sponsor_protocol_number", "listing_number", "listing_title", "study_population", "note_line", "measurements"], "properties": {"cro_study_number": {"type": "string", "description": "CRO study number from the page header, e.g. '7694-105'."}, "sponsor_protocol_number": {"type": "string", "description": "Sponsor protocol number from the page header, e.g. 'SM 08-01'."}, "listing_number": {"type": "string", "description": "Listing number from the title line, e.g. '16.2.6-1'."}, "listing_title": {"type": "string", "description": "Listing title text, e.g. 'Expired Carbon Monoxide by Subject'."}, "study_population": {"type": "string", "description": "Population named on the 'Study Population:' line."}, "note_line": {"type": "string", "description": "The page-bottom NOTE line explaining ND/UNK codes."}, "measurements": {"type": "array", "description": "Every measurement row in document order (one per timepoint).", "items": {"type": "object", "required": ["subject_number", "study_product", "timepoint", "date", "time", "eco_ppm", "cohb_pct", "comments", "source_page"], "properties": {"subject_number": {"type": "string", "description": "Subject identifier, e.g. 'R1001'; printed only on the first row of the subject's group — carry forward."}, "study_product": {"type": "string", "enum": ["Active", "Placebo"], "description": "Study product; printed only on the group's first row — carry forward."}, "timepoint": {"type": "string", "description": "Visit timepoint as printed, e.g. 'Week 6'."}, "date": {"type": "string", "description": "Measurement date as printed (YYYY-MM-DD)."}, "time": {"type": "string", "description": "Measurement time 'HH:MM', or 'ND'/'UNK' as printed."}, "eco_ppm": {"type": ["integer", "null"], "description": "ECO level in ppm; '---' prints as null."}, "cohb_pct": {"type": ["number", "null"], "description": "%COHb value; '---' prints as null."}, "comments": {"type": ["string", "null"], "description": "Comments column; null when blank."}, "source_page": {"type": "integer", "description": "1-indexed PDF page of the row."}}}}}}

Expected output:
{"cro_study_number": "7694-105", "sponsor_protocol_number": "SM 08-01", "listing_number": "16.2.6-1", "listing_title": "Expired Carbon Monoxide by Subject", "study_population": "ITT", "note_line": "NOTE: ND=NOT DONE; UNK=UNKNOWN.", "measurements": [{"subject_number": "R1001", "study_product": "Active", "timepoint": "Week 0", "date": "2009-03-02", "time": "09:36", "eco_ppm": 19, "cohb_pct": 3.6, "comments": null, "source_page": 2}, {"subject_number": "R1001", "study_product": "Active", "timepoint": "Week 6", "date": "2009-04-14", "time": "07:45", "eco_ppm": 0, "cohb_pct": 0.0, "comments": null, "source_page": 2}, {"subject_number": "R1001", "study_product": "Active", "timepoint": "Week 10", "date": "2009-05-11", "time": "08:04", "eco_ppm": 5, "cohb_pct": 1.4, "comments": null, "source_page": 2}, {"subject_number": "R1001", "study_product": "Active", "timepoint": "Week 16", "date": "2009-06-22", "time": "08:05", "eco_ppm": 2, "cohb_pct": 0.9, "comments": null, "source_page": 2}, {"subject_number": "R1001", "study_product": "Active", "timepoint": "Week 28", "date": "2009-09-11", "time": "08:04", "eco_ppm": 10, "cohb_pct": 2.2, "comments": null, "source_page": 2}, {"subject_number": "R1002", "study_product": "Placebo", "timepoint": "Week 0", "date": "2009-03-02", "time": "15:36", "eco_ppm": 14, "cohb_pct": 2.8, "comments": null, "source_page": 2}, {"subject_number": "R1002", "study_product": "Placebo", "timepoint": "Week 6", "date": "2009-04-13", "time": "11:31", "eco_ppm": 5, "cohb_pct": 1.4, "comments": null, "source_page": 2}, {"subject_number": "R1002", "study_product": "Placebo", "timepoint": "Week 10", "date": "2009-05-08", "time": "12:47", "eco_ppm": 6, "cohb_pct": 1.5, "comments": null, "source_page": 2}, {"subject_number": "R1002", "study_product": "Placebo", "timepoint": "Week 16", "date": "2009-06-24", "time": "08:54", "eco_ppm": 22, "cohb_pct": 4.1, "comments": null, "source_page": 2}, {"subject_number": "R1002", "study_product": "Placebo", "timepoint": "Week 28", "date": "2009-09-16", "time": "08:33", "eco_ppm": 6, "cohb_pct": 1.5, "comments": null, "source_page": 2}, {"subject_number": "R1003", "study_product": "Active", "timepoint": "Week 0", "date": "2009-03-03", "time": "10:17", "eco_ppm": 13, "cohb_pct": 2.7, "comments": null, "source_page": 2}, {"subject_number": "R1003", "study_product": "Active", "timepoint": "Week 16", "date": "2009-03-06", "time": "10:18", "eco_ppm": 13, "cohb_pct": 2.7, "comments": null, "source_page": 2}, {"subject_number": "R1004", "study_product": "Placebo", "timepoint": "Week 0", "date": "2009-03-09", "time": "15:08", "eco_ppm": 24, "cohb_pct": 4.4, "comments": null, "source_page": 2}, {"subject_number": "R1004", "study_product": "Placebo", "timepoint": "Week 6", "date": "2009-04-22", "time": "08:56", "eco_ppm": 4, "cohb_pct": 1.2, "comments": null, "source_page": 2}, {"subject_number": "R1004", "study_product": "Placebo", "timepoint": "Week 10", "date": "2009-05-18", "time": "08:38", "eco_ppm": 6, "cohb_pct": 1.5, "comments": null, "source_page": 2}, {"subject_number": "R1004", "study_product": "Placebo", "timepoint": "Week 16", "date": "2009-07-02", "time": "08:15", "eco_ppm": 11, "cohb_pct": 2.3, "comments": null, "source_page": 2}, {"subject_number": "R1004", "study_product": "Placebo", "timepoint": "Week 28", "date": "2009-09-21", "time": "08:29", "eco_ppm": 9, "cohb_pct": 2.0, "comments": null, "source_page": 3}, {"subject_number": "R1005", "study_product": "Active", "timepoint": "Week 0", "date": "2009-03-10", "time": "09:47", "eco_ppm": 37, "cohb_pct": 6.5, "comments": null, "source_page": 3}, {"subject_number": "R1005", "study_product": "Active", "timepoint": "Week 6", "date": "2009-04-20", "time": "11:00", "eco_ppm": 12, "cohb_pct": 2.5, "comments": null, "source_page": 3}, {"subject_number": "R1005", "study_product": "Active", "timepoint": "Week 10", "date": "2009-05-22", "time": "13:41", "eco_ppm": 22, "cohb_pct": 4.1, "comments": null, "source_page": 3}, {"subject_number": "R1005", "study_product": "Active", "timepoint": "Week 16", "date": "2009-07-06", "time": "09:04", "eco_ppm": 19, "cohb_pct": 3.6, "comments": null, "source_page": 3}, {"subject_number": "R1005", "study_product": "Active", "timepoint": "Week 28", "date": "2009-09-22", "time": "08:55", "eco_ppm": 18, "cohb_pct": 3.5, "comments": null, "source_page": 3}, {"subject_number": "R1006", "study_product": "Placebo", "timepoint": "Week 0", "date": "2009-03-11", "time": "16:42", "eco_ppm": 12, "cohb_pct": 2.5, "comments": null, "source_page": 3}, {"subject_number": "R1006", "study_product": "Placebo", "timepoint": "Week 6", "date": "2009-04-22", "time": "08:24", "eco_ppm": 32, "cohb_pct": 5.7, "comments": "Subject is still smoking", "source_page": 3}, {"subject_number": "R1006", "study_product": "Placebo", "timepoint": "Week 10", "date": "2009-05-22", "time": "15:22", "eco_ppm": 12, "cohb_pct": 2.5, "comments": null, "source_page": 3}, {"subject_number": "R1006", "study_product": "Placebo", "timepoint": "Week 16", "date": "2009-07-01", "time": "08:00", "eco_ppm": 26, "cohb_pct": 4.7, "comments": null, "source_page": 3}, {"subject_number": "R1006", "study_product": "Placebo", "timepoint": "Week 28", "date": "2009-09-23", "time": "08:41", "eco_ppm": 26, "cohb_pct": 4.7, "comments": null, "source_page": 3}, {"subject_number": "R1007", "study_product": "Active", "timepoint": "Week 0", "date": "2009-03-13", "time": "10:39", "eco_ppm": 23, "cohb_pct": 4.4, "comments": null, "source_page": 3}, {"subject_number": "R1007", "study_product": "Active", "timepoint": "Week 6", "date": "2009-04-24", "time": "09:01", "eco_ppm": 25, "cohb_pct": 4.6, "comments": null, "source_page": 3}, {"subject_number": "R1007", "study_product": "Active", "timepoint": "Week 10", "date": "2009-05-22", "time": "09:18", "eco_ppm": 0, "cohb_pct": 0.0, "comments": null, "source_page": 3}, {"subject_number": "R1007", "study_product": "Active", "timepoint": "Week 16", "date": "2009-07-02", "time": "09:04", "eco_ppm": 4, "cohb_pct": 1.2, "comments": null, "source_page": 3}, {"subject_number": "R1007", "study_product": "Active", "timepoint": "Week 28", "date": "2009-09-23", "time": "09:29", "eco_ppm": 18, "cohb_pct": 3.5, "comments": null, "source_page": 4}, {"subject_number": "R1008", "study_product": "Placebo", "timepoint": "Week 0", "date": "2009-03-16", "time": "10:16", "eco_ppm": 19, "cohb_pct": 3.6, "comments": null, "source_page": 4}, {"subject_number": "R1008", "study_product": "Placebo", "timepoint": "Week 6", "date": "2009-04-27", "time": "09:49", "eco_ppm": 9, "cohb_pct": 2.0, "comments": null, "source_page": 4}, {"subject_number": "R1008", "study_product": "Placebo", "timepoint": "Week 16", "date": "2009-05-22", "time": "10:10", "eco_ppm": 26, "cohb_pct": 4.7, "comments": null, "source_page": 4}, {"subject_number": "R1009", "study_product": "Active", "timepoint": "Week 0", "date": "2009-03-16", "time": "11:11", "eco_ppm": 32, "cohb_pct": 5.7, "comments": null, "source_page": 4}, {"subject_number": "R1009", "study_product": "Active", "timepoint": "Week 6", "date": "2009-04-27", "time": "08:52", "eco_ppm": 3, "cohb_pct": 1.1, "comments": null, "source_page": 4}, {"subject_number": "R1009", "study_product": "Active", "timepoint": "Week 16", "date": "2009-05-22", "time": "08:58", "eco_ppm": 19, "cohb_pct": 3.6, "comments": null, "source_page": 4}, {"subject_number": "R1010", "study_product": "Active", "timepoint": "Week 0", "date": "2009-03-24", "time": "08:10", "eco_ppm": 14, "cohb_pct": 2.8, "comments": null, "source_page": 4}, {"subject_number": "R1010", "study_product": "Active", "timepoint": "Week 6", "date": "2009-05-05", "time": "08:42", "eco_ppm": 18, "cohb_pct": 3.5, "comments": null, "source_page": 4}, {"subject_number": "R1010", "study_product": "Active", "timepoint": "Week 10", "date": "2009-06-03", "time": "11:55", "eco_ppm": 4, "cohb_pct": 1.2, "comments": null, "source_page": 4}, {"subject_number": "R1010", "study_product": "Active", "timepoint": "Week 16", "date": "2009-07-14", "time": "09:08", "eco_ppm": 14, "cohb_pct": 2.8, "comments": null, "source_page": 4}, {"subject_number": "R1010", "study_product": "Active", "timepoint": "Week 28", "date": "2009-10-06", "time": "10:53", "eco_ppm": 13, "cohb_pct": 2.7, "comments": null, "source_page": 4}, {"subject_number": "R1011", "study_product": "Placebo", "timepoint": "Week 0", "date": "2009-04-16", "time": "10:38", "eco_ppm": 11, "cohb_pct": 2.3, "comments": null, "source_page": 4}, {"subject_number": "R1011", "study_product": "Placebo", "timepoint": "Week 6", "date": "2009-05-29", "time": "09:07", "eco_ppm": 9, "cohb_pct": 2.0, "comments": null, "source_page": 4}, {"subject_number": "R1011", "study_product": "Placebo", "timepoint": "Week 10", "date": "2009-06-26", "time": "08:32", "eco_ppm": 7, "cohb_pct": 1.7, "comments": null, "source_page": 4}, {"subject_number": "R1011", "study_product": "Placebo", "timepoint": "Week 16", "date": "2009-08-07", "time": "08:11", "eco_ppm": 9, "cohb_pct": 2.0, "comments": null, "source_page": 5}, {"subject_number": "R1011", "study_product": "Placebo", "timepoint": "Week 28", "date": "2009-10-29", "time": "08:16", "eco_ppm": 6, "cohb_pct": 1.5, "comments": null, "source_page": 5}, {"subject_number": "R1012", "study_product": "Placebo", "timepoint": "Week 0", "date": "2009-04-16", "time": "12:45", "eco_ppm": 33, "cohb_pct": 5.9, "comments": null, "source_page": 5}, {"subject_number": "R1012", "study_product": "Placebo", "timepoint": "Week 6", "date": "2009-05-29", "time": "09:38", "eco_ppm": 33, "cohb_pct": 5.9, "comments": null, "source_page": 5}, {"subject_number": "R1012", "study_product": "Placebo", "timepoint": "Week 10", "date": "2009-06-29", "time": "13:52", "eco_ppm": 40, "cohb_pct": 7.0, "comments": null, "source_page": 5}, {"subject_number": "R1012", "study_product": "Placebo", "timepoint": "Week 28", "date": "2009-10-29", "time": "08:52", "eco_ppm": 35, "cohb_pct": 6.2, "comments": null, "source_page": 5}, {"subject_number": "R1013", "study_product": "Placebo", "timepoint": "Week 0", "date": "2009-04-22", "time": "09:22", "eco_ppm": 10, "cohb_pct": 2.2, "comments": null, "source_page": 5}, {"subject_number": "R1013", "study_product": "Placebo", "timepoint": "Week 6", "date": "2009-06-03", "time": "09:13", "eco_ppm": 4, "cohb_pct": 1.2, "comments": null, "source_page": 5}, {"subject_number": "R1013", "study_product": "Placebo", "timepoint": "Week 10", "date": "2009-07-01", "time": "09:02", "eco_ppm": 6, "cohb_pct": 1.5, "comments": null, "source_page": 5}, {"subject_number": "R1013", "study_product": "Placebo", "timepoint": "Week 16", "date": "2009-08-12", "time": "09:23", "eco_ppm": 3, "cohb_pct": 1.1, "comments": null, "source_page": 5}, {"subject_number": "R1013", "study_product": "Placebo", "timepoint": "Week 28", "date": "2009-11-04", "time": "09:06", "eco_ppm": 8, "cohb_pct": 1.9, "comments": null, "source_page": 5}, {"subject_number": "R1014", "study_product": "Placebo", "timepoint": "Week 0", "date": "2009-04-22", "time": "10:04", "eco_ppm": 38, "cohb_pct": 6.7, "comments": null, "source_page": 5}, {"subject_number": "R1015", "study_product": "Active", "timepoint": "Week 0", "date": "2009-04-28", "time": "12:04", "eco_ppm": 21, "cohb_pct": 3.9, "comments": null, "source_page": 5}, {"subject_number": "R1015", "study_product": "Active", "timepoint": "Week 6", "date": "2009-06-12", "time": "11:52", "eco_ppm": 19, "cohb_pct": 3.6, "comments": null, "source_page": 5}, {"subject_number": "R1015", "study_product": "Active", "timepoint": "Week 10", "date": "2009-07-10", "time": "15:52", "eco_ppm": 7, "cohb_pct": 1.7, "comments": null, "source_page": 5}, {"subject_number": "R1015", "study_product": "Active", "timepoint": "Week 16", "date": "2009-08-24", "time": "11:52", "eco_ppm": 29, "cohb_pct": 5.2, "comments": null, "source_page": 6}, {"subject_number": "R1015", "study_product": "Active", "timepoint": "Week 28", "date": "2009-11-10", "time": "10:28", "eco_ppm": 12, "cohb_pct": 2.5, "comments": null, "source_page": 6}, {"subject_number": "R1016", "study_product": "Active", "timepoint": "Week 0", "date": "2009-05-15", "time": "08:58", "eco_ppm": 19, "cohb_pct": 3.6, "comments": null, "source_page": 6}, {"subject_number": "R1016", "study_product": "Active", "timepoint": "Week 6", "date": "2009-06-26", "time": "09:10", "eco_ppm": 17, "cohb_pct": 3.3, "comments": null, "source_page": 6}, {"subject_number": "R1016", "study_product": "Active", "timepoint": "Week 10", "date": "2009-07-24", "time": "08:54", "eco_ppm": 11, "cohb_pct": 2.3, "comments": null, "source_page": 6}, {"subject_number": "R1016", "study_product": "Active", "timepoint": "Week 16", "date": "2009-09-04", "time": "09:24", "eco_ppm": 17, "cohb_pct": 3.3, "comments": null, "source_page": 6}, {"subject_number": "R1016", "study_product": "Active", "timepoint": "Week 28", "date": "2009-11-24", "time": "09:11", "eco_ppm": 19, "cohb_pct": 3.6, "comments": null, "source_page": 6}, {"subject_number": "R1017", "study_product": "Active", "timepoint": "Week 0", "date": "2009-05-15", "time": "09:56", "eco_ppm": 30, "cohb_pct": 5.4, "comments": null, "source_page": 6}, {"subject_number": "R1017", "study_product": "Active", "timepoint": "Week 6", "date": "2009-06-26", "time": "10:17", "eco_ppm": 7, "cohb_pct": 1.7, "comments": null, "source_page": 6}, {"subject_number": "R1017", "study_product": "Active", "timepoint": "Week 10", "date": "2009-07-24", "time": "10:14", "eco_ppm": 10, "cohb_pct": 2.2, "comments": null, "source_page": 6}, {"subject_number": "R1017", "study_product": "Active", "timepoint": "Week 16", "date": "2009-09-04", "time": "10:17", "eco_ppm": 8, "cohb_pct": 1.9, "comments": null, "source_page": 6}, {"subject_number": "R1017", "study_product": "Active", "timepoint": "Week 28", "date": "2009-11-20", "time": "16:04", "eco_ppm": 15, "cohb_pct": 3.0, "comments": null, "source_page": 6}, {"subject_number": "R1018", "study_product": "Placebo", "timepoint": "Week 0", "date": "2009-05-15", "time": "10:49", "eco_ppm": 34, "cohb_pct": 6.0, "comments": null, "source_page": 6}, {"subject_number": "R1018", "study_product": "Placebo", "timepoint": "Week 6", "date": "2009-06-30", "time": "07:57", "eco_ppm": 25, "cohb_pct": 4.6, "comments": null, "source_page": 6}, {"subject_number": "R1018", "study_product": "Placebo", "timepoint": "Week 16", "date": "2009-07-24", "time": "08:14", "eco_ppm": 3, "cohb_pct": 1.1, "comments": null, "source_page": 6}, {"subject_number": "R1019", "study_product": "Active", "timepoint": "Week 0", "date": "2009-05-21", "time": "11:45", "eco_ppm": 26, "cohb_pct": 4.7, "comments": null, "source_page": 7}, {"subject_number": "R1019", "study_product": "Active", "timepoint": "Week 6", "date": "2009-07-02", "time": "09:01", "eco_ppm": 9, "cohb_pct": 2.0, "comments": null, "source_page": 7}, {"subject_number": "R1019", "study_product": "Active", "timepoint": "Week 10", "date": "2009-08-05", "time": "08:14", "eco_ppm": 10, "cohb_pct": 2.2, "comments": null, "source_page": 7}, {"subject_number": "R1019", "study_product": "Active", "timepoint": "Week 28", "date": "2009-12-04", "time": "08:00", "eco_ppm": 12, "cohb_pct": 2.5, "comments": null, "source_page": 7}, {"subject_number": "R1020", "study_product": "Placebo", "timepoint": "Week 0", "date": "2009-06-04", "time": "11:27", "eco_ppm": 13, "cohb_pct": 2.7, "comments": null, "source_page": 7}, {"subject_number": "R1020", "study_product": "Placebo", "timepoint": "Week 6", "date": "2009-07-16", "time": "09:53", "eco_ppm": 2, "cohb_pct": 0.9, "comments": null, "source_page": 7}, {"subject_number": "R1020", "study_product": "Placebo", "timepoint": "Week 10", "date": "2009-08-13", "time": "09:50", "eco_ppm": 2, "cohb_pct": 0.9, "comments": null, "source_page": 7}, {"subject_number": "R1020", "study_product": "Placebo", "timepoint": "Week 16", "date": "2009-09-25", "time": "09:46", "eco_ppm": 3, "cohb_pct": 1.1, "comments": null, "source_page": 7}, {"subject_number": "R1020", "study_product": "Placebo", "timepoint": "Week 28", "date": "2009-11-23", "time": "08:10", "eco_ppm": 4, "cohb_pct": 1.2, "comments": null, "source_page": 7}, {"subject_number": "R1021", "study_product": "Placebo", "timepoint": "Week 0", "date": "2009-06-04", "time": "13:07", "eco_ppm": 27, "cohb_pct": 4.9, "comments": null, "source_page": 7}, {"subject_number": "R1021", "study_product": "Placebo", "timepoint": "Week 6", "date": "2009-07-16", "time": "08:30", "eco_ppm": 8, "cohb_pct": 1.9, "comments": null, "source_page": 7}, {"subject_number": "R1021", "study_product": "Placebo", "timepoint": "Week 10", "date": "2009-08-13", "time": "09:02", "eco_ppm": 30, "cohb_pct": 5.4, "comments": null, "source_page": 7}, {"subject_number": "R1021", "study_product": "Placebo", "timepoint": "Week 16", "date": "2009-09-24", "time": "08:28", "eco_ppm": 21, "cohb_pct": 3.9, "comments": null, "source_page": 7}, {"subject_number": "R1021", "study_product": "Placebo", "timepoint": "Week 28", "date": "2009-12-17", "time": "08:55", "eco_ppm": 20, "cohb_pct": 3.8, "comments": null, "source_page": 7}, {"subject_number": "R1022", "study_product": "Active", "timepoint": "Week 0", "date": "2009-06-09", "time": "10:09", "eco_ppm": 8, "cohb_pct": 1.9, "comments": null, "source_page": 7}, {"subject_number": "R1022", "study_product": "Active", "timepoint": "Week 6", "date": "2009-07-23", "time": "13:53", "eco_ppm": 32, "cohb_pct": 5.7, "comments": null, "source_page": 7}, {"subject_number": "R1022", "study_product": "Active", "timepoint": "Week 10", "date": "2009-08-20", "time": "10:22", "eco_ppm": 13, "cohb_pct": 2.7, "comments": null, "source_page": 8}, {"subject_number": "R1022", "study_product": "Active", "timepoint": "Week 16", "date": "2009-09-29", "time": "08:35", "eco_ppm": 16, "cohb_pct": 3.1, "comments": null, "source_page": 8}, {"subject_number": "R1022", "study_product": "Active", "timepoint": "Week 28", "date": 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