58
conjunctiva looks better; left cornea quite opaque, and the side which is undermost is always
bathed in sweat. A fair dropping of hardish dung, coated with dark viscid material, mucus and
bile, very foul smelling; respirations 72, labored. Temperature at rectum 105.1° F., at nostril
100.6° F.; visible mucous membranes moist, of good color.
November 19th (2 p.m.)—Rectal temperature 106° F.
November 19th (5 p.m.)—Rectal temperature 107° F.; pulse 60 ; passed a lot of soft, chocolate-
colored faeces, very strong smelling; was turned over and rubbed dry; more urine passed.
November 20th (2 a.m.)—Died.
POST-MORTEM EXAMINATION (after five hours.)—A good death stiffening; gelatinous effusion in
areolar tissue in front of chest, between muscles of thigh, and at upper part of sternum, and here
and there subcutaneously. (Edema of the lymph glands. A large quantity of milky fluid in
peritoneal sac A fair amount of serous fluid in the chest. Enormous clots in the large blood-
vessels, mainly yellow, but with purplish accumulations of red corpuscles on the surfaoe; portal
vessels full. Bowels ; here and there patches of vessels full of blood and slight extravasations of
corpuscles, sufficient throughout the small intestines as a whole to account for the nature of the
contents of the large bowel. A fair amount of serum-like fluid in the ileum. Glands of the
bowel free from disease. Large intestine containing foul-smelling, grumous, coffee-colored fluid,
but its walls healthy and no parasites present. A dark deposit on under-surface of left kidney
and much congestion of that organ. Right kidney much congested and cedematous. Urine,
specifio gravity reading post-mortem 10.35 ; no deposits. Spleen perhaps a little large and full,
otherwise no abnormality detected. Liver normal, of good size, free from parasites. Stomach
presented special and characteristic ulceration of its cuticular portion; one perforation. Mucous
membrane somewhat yellow. Contents, only a little rice, the rest having escaped through the
perforation into the belly. Right lung deeply congested, left less so; some blood extravasations
on the surface, and some along the course of intercostal veins. Heart a little fatty; extra-
vasations along its vessels, otherwise normal. Trachea full of froth ; tongue, fauces, &c, healthy.
Brain membranes normal; a fair amount of arachnoid fluid. Brain substance anaemic and looks
sodden Spinal cord (carefully examined microscopically) no disease. Discharged—died.
CASE XII—B. 54 (Illustrative of diagnosis of the disease.)
Dec. 9th,Admittedas a fresh case. Reported as very weak and in poor condition.
morning
„ 10th
„ 11th
„ 21st
„ 22nd
„ 23rd
„ 24th
„ 25th
„
„
„
„
„
„
„
Temp.
101.4° F.
100.4° F.
99° F.
104.4° F.
102.8° F
102.2° F.
97.6° F.
102.2° F.
Respr.
...
12
36
20
20
20
20
27
Pulse.
48
42
48
64
48
48
40
52
Evening
„
Temp.
101.8°
102.4°
(by Corporal Hill).
Respr.
30
Pulse.
42
....
Very cold ; eye membranes spotted; down.
Still down.
Dee. 26th, died at 1 P.M. AUTOPSY showed disease of the cuticular portion of the stomach,
extensive ulceration and yellow degeneration, the muscular coat being exposed in two places ;
villous portion healthy. Discharged—died. (This is a case which was not properly diagnosed at
first, because it came under notice when the pulse, &c, were fairly normal. More prolonged
inquiry would have shown the relapse which was just ending on 21st December.)
SUMMARY OF MEDICAL HISTORY OF THE EXPERIMENTAL MONKEY.
The patient was a young female monkey of the common Burma variety. It received spiril-
loid containing blood beneath the skin of the inner side of the thigh on 2nd February 1885,
and scratched the parts somewhat after administration. On the third day after inoculation the
parasites were numerous and active in the blood. A rise of temperature occurred on, the evening
of the second day ; some swelling took place at the seat of inoculation. A reddish discharge from
the vulva was one of the earliest events following inoculation.
The red corpuscles seemed to become much shrivelled under the action of the parasites ; the
patient suffered from high fever. On the morning of the fifth day after their first appearance
the parasites became non-detectible and remained so for four days.
The patient was brought over to India and suffered from numerous relapses ; became very
thin and weak, and with a haggard, drawn, expression of countenance.
After the second month marked deficiency in power in the legs set in, and later the feet
began to swell. Ulcers of large size formed on them and burst; the bones of the foot became
exposed; finally the upper eyelids became cedematous and the animal died after a few hours of
coma and slight delirium.
AUTOPSY.—Gave no marked positive results. The lungs were a little petechiæted on their
surface, and their was no ulceration of the gastric mucous membrane.
J. H. S.