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REPORT OF THE INDIAN HEMP DRUGS COMMISSION, 1893-94.
[APP.
Experiment No. 8.—Weight of cat 5 lb. 51/2 oz. Dose of extract .5 grain at 2 P.M. The
action of the drug began to manifest itself about 3-30 P.M., when the cat became
sleepy, but was disturbed by occasional spasmodic movements of the fore quarters.
Very definitely affected, but less so than the other cats.
The dose was now reduced to 1/90,000 of the body weight and that quantity of the extract
administered to three cats.
Experiment No. 9.—Weight of cat 4 lb 121/2 oz. Dose 37 grain at 11-30 A.M. 12-10 P.M.,
distress and discomfort, pupils slightly dilated and the cat's appearance wild and
suspicious; on being let loose the cat tries to hide itself. 12-30 P.M., displays weak-
ness of the limbs, and can only be induced to walk with great difficulty; the
weakness is more marked in the hind limbs; on walking the cat falls over occasionally
its hind quarters, apparently due to the greater weakness of the hind limbs; there
on is some tremor also of the whole body. 1-30 P.M., drowsy, but on being disturbed
still showed the weakness of the limbs. 4-30 P.M., cat went to sleep about 2 P.M.
with its nose resting on the ground and has continued to sleep with intermission
during the last one and a half hours.
Experiment No. 10.—Weight of cat 2 lb 121/4 oz. Dose .2 grain at 11-50 A.M. 12-30 P.M.,
excitement and distress with some slight occasional tremor of the whole body; slight
dilatation of the pupils. 1 P.M., asleep. 3-30 P.M., is still under influence of the
drug, and has been asleep with its nose resting on the ground during the past one
and a half hours with occasional interruptions.
Experiment No. 11.—Weight of cat 3 lb 123/4 oz. Dose .3 grain at 12-10 P.M. 12-50 P.M.,
rocking movements and drowsiness; 2 P.M., condition torpid; has broken periods
of sleep. Effect less marked than in experiments Nos. 9 and 10.
Administration of three doses equivalent to 1/100,000 part of the body weight.
Experiment No. 12.—Weight of cat 4 lb 71/4 oz. Dose of extract .3 grain at 11-35 A.M.
12-55 P.M., rocking movements of the body; appearance of the animal altered by
the drug; as it sits up it preserves a fixed look in the same direction as though some-
what dazed or stupefied. 1 P.M., asleep. 3-30 P.M., still asleep, but not deeply so, the
appearance being that presented by natural sleep. This animal displayed no weak-
ness of the limbs.
Experiment No. 13.—Weight of cat 5 lb 71/4 oz. Dose .38 grain at 11-55 A.M. 1-30 P.M.,
animal very torpid and can be induced to move only with difficulty; when disturbed,
it crawls about in a peculiar manner and seeks to hide itself; it walks in a very
peculiar manner, shuffling along with the legs doubled up underneath the body
and the belly close to the ground. 3 P.M., still under influence of the drug; some
drowsiness and slight dilatation of the pupils.
Experiment No. 14.—Weight of cat 2 lb 111/4 oz. Dose .18 grain at 12-15 P.M. 1-30 P.M.,
drowsiness; nodding of the head: the cat, which is a lively, very tame animal
is now quite dull and torpid. 3 P.M. cat asleep with its nose on the ground and
fully under the influence of the drug.
Three experiments with a dose the quantity of which was equal to 1/110,000 of the body
weight.
Experiment No. 15.—Weight of cat 4 lb 1/2 oz. Dose .25 grain at 11-15 A.M. 1 P.M.,
asleep with its nose on the ground; on being disturbed walks with great diffi-
culty, all the limbs being weak, but the hind limbs so weak that the animal
tends to fall upon its hind quarters and side. 2.30 P.M., drowsy. 4 P.M., still under
the influence of the drug, and has slept lightly off and on since 2-30 P.M.
Experiment No. 16.—Weight of cat 4 lb 51/4 oz. Dose .27 grain at 11-30 A.M. 1-15 P.M.,
expression altered, the eye being glassy and the look fixed in one direction; rocking
movements. 4 P.M., has been asleep with intermission for about two hours. While
apparently asleep with its eyes closed occasionally emitted a peculiar and unplea-
sant cry.
Experiment No. 17.—Weight of cat 5 lb 61/4 oz. Dose .34 grain at 11-50 A.M. 1-15 P.M.,
no effect apparent. 2.30 P.M. cat sleeping lightly and occasionally starting in its
sleep in a peculiar manner. It is apparently only slightly affected by the drug, but
on unfastening the string round its neck and inducing it to walk, it shows great weak-
ness of the limbs, specially the hind limbs. It is unwilling to move, and when
induced to do so, moves apparently with considerable difficulty. The gait is
tottering and unsteady, the hind quarters falling occasionally upon the ground,
4-30 P.M., the weakness of the limbs is still very marked.
In the next two experiments the dose was reduced to 1/150,000 part of the body weight.
Experiment No. 18.—Weight of cat 3 lb 11 oz.; Dose .17 grain at 1-5 P.M. 2-30 P.M.,
on being let loose is very unwilling to move, and when induced to walk moves in
a crawling, shuffling manner with its belly close to the ground. There appears to
be slight weakness of the limbs.