MUKTESAR, FOR THE YEAR ENDING THE 31ST MARCH, 1925 49
The treatments which have been investigated hitherto are:—
(i) Oil of chenopodium, at the rate of 0.1 c.c. [per kilo. body weight, in soft gelatin
capsules, followed immediately by 0.2 c. c. per kilo. of chloroform mixed
with 30 c. c. of castor oil.--8 dogs treated; one dog received 3 treatments, four
dogs received two treatments each, and three received only one treatment.
(ii) Mixture of oil of chenopodium and carbon tetrachloride in the ratio 1: 3, adminis-
tered at the rate of 0.3 c.c. per kilo. body weight in gelatin capsules, followed
by castor oil two hours later.—12 dogs treated; two dogs received three
treatments, one received two treatments, and 9 only one treatment. Two
days after treatment in this manner, arecoline hydrobromide was given by the
mouth at the rate of 1/32 grain per kilo. body weight; no tapeworms were
passed by any dog after this treatment, although some had been passed with
the preceding treatment.
(iii) Carbon tetrachloride alone, at the rate of 0.3 c. c. per kilo. body weight, in
gelatin capsules followed immediately by one-half ounce of magnesium
sulphate in saturated solution.—7 dogs treated; one dog received two
treatments, and 6 received only one treatment each.
The general results from the examination of the fæces and close inspection of the egg
curves can be readily summarized alike for all three methods. The drugs gave poor
indications of their value in the treatment of Ankylostomum caninum infection. Adult
worms were rarely passed in the fæces after treatment, and the drugs were found, at
best, to exercise a temporary check on the fecundity of the female worms, the number
of eggs passed in the fæces soon returning to their normal frequency after the date of
treatment.
It is not improbable that the relative failures were due to the drugs not being released
in the bowel in proximity to the worms. In such dogs as were examined post-mortem
the hookworms were found rather low down in the small intestine, and the drugs may
have escaped from the gelatin capsules (Parke, Davis & Co.'s manufacture) and become
absorbed before the worms were reached. Experiments are in progress to test the effect
of coating the capsules with substances such as keratin not soluble in the gastric juice,
that will not be dissolved or disintegrated until contact with the alkaline intestinal juices
is established.
Acknowledgments.
In the execution of the details of work the services of the following officers are acknow-
ledged :—Mr. J. R. Haddow, in general administration, in control of the branch institute,
and researches into blackquarter and surra, in all of which he has been actuated with a
high sense of duty; Messrs. Bennett and P. C. Banerji, hæmorrhagic septicæmia:
Messrs. Bennett and Torabaz Khan, bovine contagious abortion; Messrs. Cooper, Sathe,
and Krishna Iyer, pathological duties ; Mr. Cooper, for control of instructional duties
and studies into protozoan affections; Mr. M. B. Menon, for unstinted assistance in rinder-
pest, strangles, and anthrax researches and Mr. J. D'Costa in the supervision of the clinical
part of the work ; the services of Mr. D. Keiller in mallein, blackquarter, and vaccine
production researches have been most meritorious ; Mr. G. P. Goffi, on his own initiative,
took over the arduous task of checking the accounts system for inspection by the auditors,
in addition to his former duties, and his zeal has been an invaluable asset; Mr. W. Mobbs,
for acquiring skill in routine bacteriological work; Mr. Abdul Ghani, for much ability
in the administration of the branch institute; Veterinary Inspectors Khan Sahib Wazir
Mohammed, Balwant Singh, and Rajagopalam for invaluable support in outside technical
duties ; it was much regretted that Mr. W. Pryde Watson terminated his versatile and
competent services as engineer at the close of the year; Capt. A. J. Hearsey, deserves
credit for the work accomplished in cultivation and farm management; Mr. S. K. Sen,
for his invaluable assistance in literary matters, besides carrying out the entomological
researches; Mr. Amar Nath Gulati, for thorough work in executing the helminthological
researches. As.in former years Rai Sahib Pt. Krishna Nand continued to give the insti-
tution the benefits of his unique experience extending over 30 years in its special adminis-
trative problems, and the great ability and tact which he has been able to bestow upon
them will be surely missed when the time comes for his retirement. The other members
of the office staff served loyally and without complaint in spite of the pressure of work
put on them, and special mention must be made of Munshi Azimushan Khan, Officiating
Head Clerk, Pt. Ram Datt, Accountant, and B. Godar Mal, Officiating Second Clerk.
All other ranks strove to maintain a reputation for hard and reliable work.