14
TABLE X.
Cystitis and Bacilluria.
Serial
num-
ber.
Case
num-ber.
Medical Officer.
Disease.
Vaccine made.
Result.
1
3 The Superintendent, Government
Maternity Hospital, Madras.
Chronic cystitis . . . B. Coli . . . Not used.
2
16 Dr. T. V. Subba Rao, Triplicane . . . Bacilluria . . .
Do. . . . Cured.
3
51 Dr. T. S. S. Rajan, Srirangam . . . Cystitis . . . Do. . . .
Not known.
4
79 The District Medical and Sanitary
Officer, Cocanada.
Bacilluria . . .
Do. . . . No effect.
5
96 Miss M. Alexander, M.A., M.D., Ton-
diarpet.
Do. . . .
Do. . . . Not known.
Other infections.— Of the three cases included. in this group, the only interesting one (case
5 4 ) w a s o f a y o u n g l a d y w h o f o r w e e k s w a s s u f f e r i n g f r o m i r r e g u l a r f e v e r . C u l t u r e s f r o m t h e
blood gave a growth of staphylococcus. The autogenous vaccine administered along with other
- t r e a t m e n t r e s u l t e d i n a r a p i d r e c o v e r y .
TABLE XI.
Other Infections.
Serial
num-
ber.
Case
num-
ber.
Medical Officer.
Disease.
Vaccine made.
Result.
__
1
54 The Second Physician, General,
Hospital, Madras.
Irregular fever . . . Staphylococcus . . . Cured.
2
82 Miss M. Alexander, M.A., M.D., Tondiar
-pet.
Acute dysentery . . . B. Dysenteriæ . . . Not used.
3
90 The Resident Medical Officer, General
Hospital, Madras.
Chronic colitis . . . B. Coli . . .
Do.
STOCK VACCINES.
Gonococcus vaccine .—The result of treatment with stock gonococcus vaccine was
eminently satisfactory. Autogenous vaccines are rarely needed in gonococcal infections and
in the majority of cases where the urethritis has merged into the subacute or chronic stage
and in the metastatic complications it is difficult or impossible to isolate the organism for the
preparation of the autogenous vaccine. The experiences of the different medical men who have
used the vaccine are unanimous as regards its utility in the different gonorrhœal conditions.
Cases of urethritis are not always certain in their amenability to vaccine treatment. A
number of cases improve up to a certain point and then merge into a chronic state which yields
neither to vaccines nor to local or systemic medication. A certain percentage of the cases
recover completely, no trace of the urethral discharge being evident and no complication
arising in later life. A small minority of the cases are reported to have got worse by the
vaccine treatment, but this is almost certainly due either to insufficient treatment when the
disease is normally becoming more acute or to reaction following too high doses. Whether
the urethritis is completely cured or not, the vaccine has a decided value in the prevention of
complications and for this, if not for any other reason, it is desirable that every case of
gonorrhœal infection, whether in the acute or chronic stage, should be put under a course of
gonococcus vaccine treatment.
As regards the dosage, in the acute stage the smaller doses, i.e., 2, 5, 10 and 20 million
give the best results, the higher doses causing severe reactions with exacerbation of discharge
and delay in recovery. In the metastatic troubles and in subacute and chronic urethritis the
larger doses, 10, 20, 50, 100 and 200 million give the best results. How far the dosage can,
or should, be pushed is not easy to judge but the majority of the cases seem to bear a 200
million dose well, whilst others cannot be taken beyond 100 million and still others can, be
run up to 500 million or even more. Each case has to be studied on its own merits, the main
point to be kept in view being the avoidance of severe reactions, which, as in the gonorrhœal
infection of a delicate organ like the eye, may lead to the most disastrous consequences.
As is seen in the tabular statement, stock gonococcus vaccine was a s f o u n d t o b e b e n e f i c i a l
in a variety of conditions including urethritis, arthritis, synovitis, fascial inflammations,
orchitis, epididymitis, endometritis, salpingitis, peritonitis, cystitis and a number of gonococcal
eye affections including conjunctivitis, keratitis, corneal ulceration, iritis, iridocyclitis, uveitis,