9
of a camel which had only presented the trypanosoma in its blood during
a period of a few three or four months. After the usual period of
incubation, the trypanosoma appeared in the blood, and during a period of
685 days, large numbers of paroxysms and intermissions were passed through
until towards the end of the period the trypanosoma could no more be found
in the peripheral circulation of the animal, and its blood when injected in
large quantities into a second healthy equine failed to reproduce the disease.
On the 18th December 1904, the horse which primarily received camel surra
and eradicated the trypanosoma from its system, was inoculated a second
time, but on this occasion with the T. Evansi. Again the animal passed
through repeated paroxysms and intermissions after an incubation period
lasting 7 days. Unfortunately, on the 102nd day of disease, having lived
nearly three times the average of a horse inoculated with equine surra, the
animal met with an accident and succumbed. Otherwise, there was no evi-
dence that the animal might not have continued to live.
38. On the 24th November 1904, two experiments with a similar end in
view were initiated, two horses receiving 20 c. c. of blood subcutaneously from
a fresh case of camel surra.
These animals at a later date will be tested with equine surra, in order
to prove if any protection has been afforded by the trypanosoma of camel
Surra.
39. By the administration of certain chemicals.—The only equines, the
subjects of T. Evansi in their circulation have been cured up to the present,
are the three animals submitted to Arsenic and Mercury, between 1893 and
1895, at Poona. Various drugs have been administered by different observers
throughout the Eastern and Western hemispheres, but any beneficial results
have always been through the agency of arsenic in some form, either by itself
or in combination with some other chemicals. For some months past, through
the kindness of Professor Ehrlich, who supplied the substance in quantity in
order to test its efficacy in combination with arsenic, an extensive series of
experiments have been initiated with trypan-rot * which had proved, when
* (Tetra zoieete benzidin-monosulfosäure and injected subcutaneously, efficacious in the
Naphtbglanüdi sulfosäure Natron.)
treatment of the T. Equinum in mice.
This trypanosoma is the casual agent in "Mal de Caderas" a form of
trypanosomiasis affecting equines and bovines in South America, presenting
symptoms very similar to Surra (T. Evansi) in the East. A considerable
number of observations have been conducted with arsenate of soda, trypan-rot
and the two concurrently given, as well as in combination. The results
obtained, up to the present, are favourable to a cure being eventually brought
about by the administration of these chemicals, but much work remains to
be accomplished in this direction before a report can be submitted with regards
to the results arrived at.
40. Charbon Symptomatique.—Up to the present, a number of experi-
ments have been made, but it has been found impossible to cultivate the
Bacterium of Charbon Symptomatique at an altitude of 7,500 feet with the
material at our disposal and, therefore, no serum has been prepared. A vaccine
as first introduced by Messrs. Arloing, Cornevin and Thomas has, however, been
made, and also a second one as suggested by Professor Kitt. Both of these
vaccines will be available for use in the field during the coming rainy season.
41. Dourine.—Since the submission of my Dourine Report in March
1904, a large number of cases of the disease have remained under observation,
while new cases in equines have been received. Four mares which have all
passed through attacks of the disease varying in severity, and which have been
untreated, show but slight indications of the results of the malady. In three
mares, varying but slight degrees of lameness persist, while the patches of
leucoderma previously present, during a period of 12 to 15 months, have
gradually decreased in size or totally disappeared, so that but little indication
now remains of any of the animals having passed through a severe form of the
disease.
956
C