48
Periods.
Observation...
...
...
...
Succeeding 2nd inoculation
Ditto
ditto
Days.
57
8
29
Blood
of
animal.
Bandi-
coot.
Quantity
inoculated,
c.c.
3.25
subcut.
No. of
Hæ.
Swarming
Red corpus-
cles in
1 c. mm.
5,249,298
{ 5,001,250
4,874,827
White
corpuscles
in
1 c.mm.
15,997
17,312
14,000
Coarsely
granular
corpuscles
in
1 c.mm.
2,095
2,750
1,786
Ratio of
W.C.to
R. C.
1 :328
1:288
1 :348
Ratio of
C. G. C.
to W. C.
1: 7.6
1: 6.3
1: 7.8
Ratio of
C.G.C.
to red
corpus-
cles.
1: 2.505
1 : 1.818
1 : 2.729
The animal was now again inoculated subcutaneously, three times in succession, with an
interval of two days between the first and second, and five between the second and third inocu-
lations. After the latter, the examination was continued for a further period of five days,
during which the blood remained free from organisms.
Periods.
Succeeding 3rd inoculation
Ditto
4th
ditto
Ditto
5th
ditto
Days.
3
5
5
Blood
of
animal.
}Bandi-
coot.
Quantity
inoculated
c.c.
2.4
{ 2.6
trace.
No. of
Hæ.
Swarming
Teeming
V.N.
Red
corpuscles
in
1 c. mm.
4,996,000
4,990,000
5,100,000
White
corpuscles
in
1 c. mm.
23,600
18,800
20,400
Coarsely
granular
1 c. mm.
1,400
480
1,120
Ratio of
W. C. t.
R. C.
1 :211
1 :265
1 :250
Ratio
C. G. C.
to W. C.
1: 16.8
1: 39.1
1: 18.2
Ratio
C. G. C.
to red
corpus-
cles.
1 : 3,568
1 : 10,395
1 : 4,553
After a period of ten days during which the observations were continued, it was decided
to administer gradually increasing doses of the Iodides of Arsenic and Mercury, with a view to
determine the changes, if any, which such drugs produce, and further, whether the animal,
which up to the present had been refractory to the hæmatozoon, would become more susceptible,
as the drug had been previously observed in one case to produce such effect. After waiting a
period, the animal was again inoculated subcutaneously, with 2 c.c. of Bandicoot's blood contain-
ing very numerous hæmatozoa. As no local symptoms supervened, five days later a further
7.5 c.c. of blood containing numerous hæmatozoa were injected.
Periods.
Observation
...
...
Administration of Io-
dides.
After Iodides
...
...
Succeeding 6th Inocula-
tion.
Do.
7th Inocula-
tion.
Days.
10
24
31
5
22
Blood
of
animal.
...
...
...
}Bandi-
coot.
Quan-
tity
inocu-
lated
c. c.
...
...
... { 2.0
7.5
No. of
Hæ.
...
...
... V.N.
N.
Double
Iodides of
Mercury
and
Arsenic.
Grains.
...
143.78
each.
... ...
Red
corpuscles
in
1 c. mm.
5,136,000
5,671,500
4,792,580
8,820,000
3,785,000
White
corpuscles
in
1 c. mm.
15,040
13,500
13,193
14,360
24,463
Coarsely
granular
in
1 c. mm.
1,140
1,583
1,503
2,040
3,182
Ratio
W.C.
to
R. C
1 :345
1 :420
1 :363
1 266
1 :154
Ratio
C. G. C.
to W. C.
1 :13.20
1 :8 .5
1 :8 .7
1 :7 .0
1 :7 .6
Ratio
C. G. C.
to red
corpus-
cles.
1 :4,605
1 :3,582
1 : 3,188
1 :1,872
1 :1,189
SUMMARY SHOWING THE NUMBER AND RATIOS OF THE CORPUSCULAR CONSTITUENTS OF THE BL
OF SURRA HORSES, SUBJECTED TO TREATMENT WITH ARSENIC AND IRON, TOGETHER WITH
THE DAYS OF DISEASE AND TREATMENT, AND THE AMOUNT OF THE DRUGS ADMINISTERED WHEN
A CURE WAS EFFECTED, AND WHEN DEATH FOLLOWED RESPECTIVELY.
(i) Corpuscular elements in health.
Horse—Mule—Donkey.
(ii) During treatment of Surra.
No. I.— Corpuscular Elements in Health.
According to Hayem. the blood of the horse in health contains 7,403,000 red, and 9,500
white corpuscles in cubic millimetre of blood, or a ratio of 1: 779. The mean number of red
corpuscles per cubic millimetre according to Smith is 7,212,500, but with regard to the white
he states : "They exist in the proportion of 1: 335 of red (Landois and Stirling), but vary in
their proportion, according to the vessel from which the blood is examined." This would give
a mean of 21,529 white in 1 cubic millimetre of blood.
In Poona, the following were the mean number of corpuscles recorded in the blood of
healthy animals, during periods of observation varying in length :—