61
power increased throughout the course of the disease, but was especially marked in the intermis-
sions, when the organism was absent, and the temperature consequently low. Vide Tables XV,
XXII and XXVIII.
Effect of Iodides on Urea, &c.—A point of interest and utility to be observed in this
investigation is the enormous effect of the Iodides of Arsenic and Mercury in animals on the
excretion of urine, urea, and hippuric acid. In the case of the urine and urea, the first effect
was observed some three weeks after the administration of the drug commenced. The excretion
increased considerably while the drug was being given, but the full effect did not occur until
after it had been discontinued. Vide Table III, page 18.
Arsenic as Liquor Arsenicalis, administered to equines, diminishes the output of urea, but
tends to favour the excretion of hippuric acid, which in untreated cases practically ceases early
in the disease. The iodides also produced a marked effect on the corpuscular elements in the
blood of the Donkey, increasing the red, and decreasing the white and coarsely granular oxyphile
cells. Vide Table XXXVI.
Water Excretion.—A point of interest to be noted is the manner in which water excreted
as urine and in dung, varies in an inverse ratio throughout the course of the disease (Surra).
The amount excreted as urine increased, and that of the dung decreased, whilst that by the
lungs and skin remained practically stationary. In contra-distinction to the above, in animals not
the subjects of Surra, but which had been subjected to the iodides, both the water in the urine
and dung decreased, while that by the lungs and skin increased considerably.
TABLE XLVI.
Showing the inverse ratio of the percentage of water excreted as urine, and in dung: 1st in
animals the subjects of Surra, 2nd in healthy animals after treatment with the Iodides of
Arsenic and Mercury.
Surra Animals
...{
Healthy Animals ... {
Animals.
Horse,LXXXIX...
(2nd Series)...
Mule I
Mule II...
...{
Horse LXXX...
(1st Series)...
Donkey IV ... {
Periods of observation.
Health
At death
Health
At death
Health
At death ...
...
1st, week
26th week...
...
1st week
...
...
8th week
...
...
(after iodides).
Urine
%
18.57
32.08
11.45
57.55
10.49
19.01
27.82
17.00
29.43
11.35
In dung
%
43.29
31.36
46.11
0.72 .
46.31
28.14
52.17
51.25
35.73
24.63
By lungs and
skin %
38.14
36.56
42.44
41.73
43.20
52.85
20.01
31.75
34.84
64.02
Hæmoglobin.—It is of great interest to note the marked increase of hæmoglobin, in the
blood of the horse and mules, during the latent period of Surra, as it occurred in all the equines
examined; but this increase was not observed in guinea pigs. The rise in hæmoglobin was always
co-existent with a considerable increase in the number of red corpuscles.
When once the disease declared itself, there was a gradual diminution in the number of red
corpuscles during the paroxysms and intermissions, and a corresponding fall in the percentage
of the colouring matter of the blood, thus accounting for the progressive pallor of the visible
mucous membranes, which is so marked a symptom of this disease. Vide Tables XVII, XXIII,
XXX, XXXVII-VIII.
B 563—16
BOMBAY : PRINTED AT THE GOVERNMENT CENTRAL PRESS.