24
Urea.—During the period of health the daily average excretion was 31.95 grammes ; this
was more than doubled (73.09) during the preliminary administration of Arsenic. After inocula-
tion it fell to a daily average of 62.37 grammes, increased again during the six paroxysms to
91.92 grammes, and again fell during five intermissions to 87.33 grammes.
Hippuric Acid. - During the 21 days' health the daily average excretion of hippuric acid
was 12.23 grammes. During the period of 54 days occupied by the preliminary treatment of
Arsenic, the daily average for the first 21 days was 7.7 grammes, whilst that for the succeeding
15 days fell to 3.4 grammes, after which for the remainder of the case no hippuric acid was
excreted.
Albumen.—No albumen appeared in the urine until the latter half of paroxysm III ; after
which it was present in the urine until the end of the case, the largest amount being passed
during the last intermission and paroxysm. The total amount excreted during 22 out of 29
days was 35.4277 grammes, or a mean daily quantity of 1.610 grammes. Less albumen was pass-
ed during the paroxysms than in the intermissions, the ratio being as 1: 2.16.
Arsenic in the form of Liq. Arsenicalis was administered during a period of 54 days
before inoculation, 320.7 grains being given. During the latent period the drug was disconti-
nued, but in paroxysms I and V, 22.50 and 8.0 grains were given respectively. In addition, during
paroxysms I and II, and intermissions I and II, 29.97 grains of each of the Iodides of Arsenic
and Mercury were administered.
Horse No. XCIX.
Australian bay gelding, aged. Body weight 911 lbs.
Urine. -During a period of eight days' health, the average daily output was 2,721 c.c. The
effect of the double iodides administered for 46 days was to raise the average daily quantity to
3,336 c.c. After subcutaneous inoculation with Surra, the latent period, occupying four days,
showed a further daily increase to 4,107 c.c. The paroxysmal average for 26 days was again
very high, viz., 8,510 c.c. and that during the intermissions lasting 36 days was only slightly
less, viz. 8,430 c.c., this polyuria being probably due to the continued exhibition of the double
iodides.
Urea. - In health the daily average excretion was 38.89 grammes; this amount was doubled
by the administration of the iodides, and further increased during the period of incubation to
82.05 grammes. The latter quantity was almost doubled during the 24 days paroxysms, but
fell to 124.95 grammes in the 36 days intermissions.
Hippuric Acid.—The average daily excretion during the period of health, lasting eight days,
was 13.14 grammes, and during the preliminary treatment, when iodides were administered, the
amount fell to 8.75 grammes. For the last 15 days of this treatment no hippuric acid was
excreted, and from this time until the end of the case, 64 days later, no more was found.
Double iodides were administered during a period of 46 days before inoculation, 158 grains
of each being given. During the latent period and two days of the first paroxysm, the drugs were
discontinued, after which it was administered until the end of the case. In all, 347 grains each
of the double iodides, and in addition 107.5 grains of arsenic, as Liquor Arsenicalis, were given
during the 118 days the case lasted.