21
The means for the whole period of 26 weeks are : —
Urine, 20.17, in dung 49.48, and by lungs and skin 30.34.
The gradual falling off in the percentage of water excreted as urine, was probably due
to the diminishing effect of the double iodides of Arsenic and Mercury, administered to the
animal for 15 weeks previous to the above observations being made.
Horse No. XCI.
Australian gelding, aged 10 years, height 15-1, body weight 825 lbs.
This animal was subjected to experiment in Bombay, in order to test whether Rat
(Mus decumanus) excrement, obtained from animals in whose blood the Trypanosoma
was present at the time of collection, could communicate the disease when such excrement
was administered daily in the corn.
After a period extending over five months the horse contracted the disease and was
placed on a treatment of Arsenic. The following observations regarding the quantities of
urine, urea, &c., were noted during the course of the disease:—
Urine.—During a period of 111 days, including four paroxysms of Surra occupying
18 days, and three intermissions lasting 93 days, the largest quantities of urine 4,189 c.c.
and 4,180 c.c. were passed during the first and second paroxysms.
The average daily quantity voided during the paroxysms was 3,103 c.c., intermissions
1,698 c.c., and for the whole period 1,926 c.c.
Urea.—The mean maximum daily amount of urea, 153.69 grammes, was passed during
the second paroxysm; the mean daily average for the paroxysms being 99.91 grammes,
whilst that for the intermissions was only 41.36 grammes.
Arsenic.—This drug was administered 24 hours after the appearance of the organism
in the blood, and was continued throughout the case, the animal showing reluctance to it.
The total quantity during the case was 658.5 grains. A small quantity of the iodides of
Arsenic and Mercury were given during the III intermission and IV paroxysm, and in ad-
dition Sulphate of Iron was administered during the latter half of the case.
Hippuric Acid. — There was no hippuric acid during the first paroxysm, but during the
succeeding intermission, an average daily of 9.730 grammes was excreted. In paroxysm II
this rose to 25.31 grammes, but again fell to 14.92 in the intermission. In the next paroxysm
the mean daily was 15.79 grammes, but was only 1.05 in intermission III. In the sixth
and last paroxysm it rose to 6.49 grammes daily. The mean for the paroxysms and inter-
missions was 15.02 and 12.87 grammes, respectively. The hippuric acid was excreted
during 8 out of 11 days paroxysm, and in 81 out of 93 days intermission.
Albumen.—Traces of albumen were excreted during the intermission II, and paro-
xysm IV only, a total of 1.123 grammes.
No investigations were made during the health period on account of the animal being
in Bombay, where the rat excrement was administered; and the horse was only received
at the Poona Laboratory the day the disease made its appearance.
TABLE VI,
HORSE XCI. Showing the mean daily averages and ratios, in health and treated Surra,
of the Urine and its chief constituents, &c., together with the water drunk.
Periods.
Length Days.
Urine
Ratio
Urea
Ratio
Hippuric Acid
Albumeu
Water
Ratio
Ratio Urea to Urine ..
Ratio Urine to Water ...
Arsenic
Iodides As
I 3
Hg I 2
Iron Sulphate
Quantity.
c.c.
Grammes.
Grammes.
Grammes.
Litres.
1:
1:
Grains.
Grains.
„
Grains.
I.
Parox-
ysm.
6
4,189
1
99.89
1
...
8.45
1
41.9
2.02
34.0
...
...
I.
Inter-
mission.
26
2,282
.54
48.86
0.48
9.73
8.00
0.94
46.70
3.50
209.0
...
...
II
Parox-
ysm.
4
4,180
.99
153.69
1.53
25.31
...
7.55
0.89
27.20
1.81
39.5
...
...
II.
Inter-
mission.
63
1,440
.34
35.46
0.35
14.92
1.104
6.45
0 76
40.61
4.47
360.0
...
...
60
III.
Parox-
ysm.
2
1,775
.42
51.47
0.51
15.79
9.12
1.07
34.50
5.14
12.0
...
...
240
III.
Inter-
mission.
4
1,969
.47
84.82
0.84
1.05
...
5.56
0.35
23.20
2.82
4.0
4.74
4.74
480
IV.
Parox-
ysm.
6
1,742
.41
80 25
0.80
6.49
0.019
3.42
0.40
21.70
1.96
00.0
6.0
6.0
600
Parox¬
ysm.
18
3,103
.74
99.91
1.00
15.02
6.65
0.78
31.05
2.14
85.5
6.0
6.0
840
Inter-
mission.
93
1,698
.40
41.36
0.41
12.87
6.85
0 .81
41.09
4.03
Totals.
573.0
4.74
4.74
540
Whole
Period.
111
1,926
.46
50.83
0.50
*13.10
6.82
0.80
36.83
3.54
658.5
10.74
10.74
1,330
Remarks.
* days 104.
B 563—6