59
Periods.
Days.
Donkey ...
Succeed-
ing 1st
Inocula-
tion.
6
Grammes.
23.78
Succeed-
ing 1st
Inocula-
tion.
23
Grammes.
19.30
Observa-
tion.
57
Grammes.
19.59
Succeed-
ing 2nd
Inocula-
tion.
8
Grammes.
22.39
Succeed-
ing 2nd
Inocula-
tion.
29
Grammes.
16.95
Succeed-
ing 3rd
Inocula-
tion.
3
Grammes.
12.49
Succeed-
ing 4th
Inocula-
tion.
5
Grammes.
10.65
Succeed-
ing 5th
Inocula-
tion.
5
Grammes.
13.37
Observa-
tion.
10
Grammes.
10.02
Adminis-
tered
Iodides.
24
Grammes.
11.22
After
Iodides.
31
Grammes.
14.43
Succeed-
ing 6th
Inocula-
tion.
5
Grammes.
16.43
Succeeding
7th Ino-
culation.
22
Grammes.
18.61
Hippuric Acid.—With regard to the presence of hippuric acid in the urine of the horse and
mule, it will be noted, on reference to the accompanying table, that in health and at rest, the
amount of this acid excreted varied very greatly, and in two animals (Nos. XCI and XCVI)
it was absent altogether. In the same horse (LXXXIX) having almost the same amount of
exercise, the hippuric acid was as 1: 2 in different years. In the case of the two mules under
observation, the amount was as 1: 19.74. During the latent period, the hippuric acid excreted
by the untreated animals increased in amount in three out of five cases, remained stationary in
one, and the quantity decreased in one ; but in all five animals, there was a decrease from the
latent period during the paroxysms and intermissions. In those animals treated after inocula-
tion, the effect produced by the administration of arsenic was the reverse of the above—
considerable quantities being passed during the paroxysms and intermissions of the disease.
The effect of the preliminary treatment (Horses Nos. XCVIII, XCIX) with Arsenic and
the double Iodides of Arsenic and Mercury, was to reduce the hippuric acid from 3.1 and 1.5
respectively to 1, and to stop its excretion altogether during the remainder of the periods the
animals lived.
The effect of Arsenic as Liq. Arsenicalis on the excretion of hippuric acid in the horse,
would appear to be a slight reduction in the amount, whereas the effect of the Iodides of Arsenic
and Mercury is to reduce the hippuric acid to a minimum, and when the drug is left off, to stop
the excretion of it altogether for a time.
In the case of the animal LXXXIX, which received the double iodides during convales-
cence from Surra, the effect produced was to reduce the amount of hippuric acid excreted
during the administration of the drug; but when the iodides were discontinued, the excretion
ceased altogether for a considerable time, viz., 163 days.
Donkey.—There was usually a decrease in the amount of hippuric acid excreted after
unsuccessful inoculation, but the quantity again rose during the period succeeding. During the
administration of the Iodides of Arsenic and Mercury, the amount was reduced by 33 %; after
the discontinuance of the drugs there was a still further reduction, which when compared with
that excreted during the period of observation, amounted to 81.07 %.
TABLE XLV
Showing the mean daily amount, in grammes, of Hippuric Acid excreted in the urine during periods
of health, preliminary treatment, and after the inoculation and subsequent treatment of Surra.
Treated
or
untreated.
Untreated
... {
Treated... ... {
Preliminary
Treatment. {
Untreated
...{
Animals.
Horse No. XCIl ...
„
„ XCIII ...
„
„
XCI ...
„
„ XCVI ...
„
„ LXXXIX
(I Series).
„
„ XCVIII.
„
„ XCIX ...
„
„ LXXXIX.
(II Series).
Mule No. I... ...
„
„ II
Health.
Grammes.
7.88
3.48
0.00
0.00
11.08
12.33
13.14
21.46
1.37
27.05
Prelimi-
nary
Treat-
ment.
Grammes.
...
...
...
...
...
3.94
8.75
...
...
...
Latent
Period.
Grammes.
12.22
3.48
0.00
7.19
18.62
...
...
15.73
10.15
27.94
Parox-
ysms.
Grammes.
1.36
2.79
15.02
4.58
12.49
...
...
3.79
3.48
6.60
Intermis-
sions.
Grammes.
0.36
0.00
12.87
6.24
...
...
...
...
6.24
...
Arsenical
Treat-
ment.
Grammes.
...
...
...
...
16.14
...
...
...
...
...
Iodides of
Arsenic
and Mer-
cury.
Grammes.
...
...
...
...
2.18
...
...
...
...
...
Period of
convales-
cence.
Grammes.
...
...
...
...
*Nil 14.87
...
...
...
...
Mean daily
walking
exercise.
Miles.
Nil.
Nil.
Nil.
Nil.
† 5.06
Nil.
Nil.
‡ 5.35
§ 2.03
3.78
Remarks.
*163 days nil
63 „ 14.87.
† For 182 days.
...
...
‡ First 60 out
of 73 days.
§ Four parox-
ysms
and
one intermis-
sion out of
11 paroxysms
and 10 inter-
missions.