E. L. TAYLOR AND K. M.
SANDERSON
166
observations involving some 300 to 400 sheep, 70 to 80 goats and a dozen cattle.
In the small intestine of these animals it is less efficient but removes about 80
per cent of the trichostrongylid parasites there, with the exception of Nemato-
dirus, on which it exerts very little action.
There is no action against Fasciola nor against the anoplocephaline cestodes
Moniezia and Anoplocephala.
Ten grammes appears to be an adequate dose in sheep or goats although
doses of 20 to 30 grammes are more likely to produce the maximum effect.
Cattle respond well but are much less tolerant of the drug than are sheep
or horses.
Experiments on pigs and dogs have been few but it is clear that although
the drug acts well on ascarids in the horse its action against these parasites is
uncertain in the pig and is absent in the dog.
The anthelmintic effect noted on sheep that have been more or less heavily
infested with stomach worms has been extraordinarily good and, where com-
parisons have been made, has generally been superior to that of copper sulphate
and nicotine sulphate.
The tolerance of sheep and goats is very high, 400 grammes causing no ill
effect : horses withstand up to 17 times the anthelmintic dose.
Some evidence of idiosyncrasy has been observed in that a group of goats
showed some sensitivity to the drug on one occasion and on a later occasion
proved to be very resistant to toxic action.
Repeated small doses are considerably more toxic than are occasional
larger doses, the minimum toxic single dose being about forty times as great as
the minimum toxic dose when repeated daily.
The tasteless character of phenothiazine is a great advantage in that horses
will take it voluntarily in the food ; pigs and sheep may also be dosed in this
way.
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G 2