161
appear on the left, accompanied by swelling and œdema of the palpebral conjunctivæ, but no petechiæ were observed.
On the 11th day the swelling had disappeared from the face, but the next day swelling of the left palpebral conjunc-
tiva was present, and lasted one day. On the 16th day, swelling of the right side of the face became apparent ; and
two days later, both sides were affected, and lumps of exudation were observed at the root of the ears. On the 21st
day, both eyes were occluded in consequence of considerable œdema of the conjunctivæ of both the upper and lower
lids. The root of the tail for two inches was also the seat of considerable swelling and exudation. The symptoms of
occlusion of the eyes passed off by the morning of the 23rd day, but the face remained swollen ; and at a later date,
the animal developed an acute nasal catarrh, accompanied by sneezing, together with an elephantine condition of the
left hind limb, which became swollen and the seat of an extensive œdema, the limb being at the very least, twice the
size of the right. When this limb decreased in size the front one on the same side assumed enormous proportions ;
but this condition only lasted for twenty-four hours, and then the right hind limb became similarly affected. The
appetite has never failed since the date of inoculation ; and at times it has been ravenous, although the animal was
given a liberal supply.
From the 12th of September to October 21st the hæmatozoa have, with four exceptions, been constantly present
in the blood.
DOG I.—A YOUNG PARIAH.
Date.
1892.
August
„
„
„
28
...
29
...
30
...
31
...
September 1 ...
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
2
...
3
...
4
...
5
...
6
...
7
...
8
...
9
...
10
...
11
...
12
...
13
...
14
...
15
...
16
...
17
...
18
...
19
...
20
...
21
...
22
...
23 ...
24 ...
25
...
26 ...
27
...
Day of
Disease.
...
...
...
...
...
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
Temperature °C.
A.M.
38.6
39.2
39.0
38.8
39.2
38.9
39.6
38.7
39.0
39.0
39.0
38.7
39.5
39.6
39.3
39.3
39.5
39.8
40.1
39.2
40.1
40.2
40.2
40.0
40.2
40.0
40.4
40.2
40.3
40.1
...
P.M.
39.3
39.3
38.8
39.1
39.8
39.1
38.7
38.2
40.0
39.6
38.8
39.0
39.4
39.8
39.3
39.6
40.0
40.0
40.2
39.3
40.4
40.5
40.0
39.2
40.0
40.0
40.2
39.3
38.9
...
...
Hæmatozoa
in Blood.
Healthy ...
Absent ...
„ ...
„ ...
„ ...
Very numerous.
Few ...
„ ...
„ ...
Numerous ...
Few ...
Numerous ...
Few ...
„ ...
„ ...
Absent ...
Few ...
Numerous ...
Few ...
Very numerous.
Absent ...
„ ...
Few ...
„ ...
„ ...
Very numerous
Swarming ...
„ ...
„ ...
Teeming ...
........
REMARKS.
Subcutaneously inoculated in the right inguinal region
with 0.6 c.c. of blood, containing very numerous
hæmatozoa, taken from the jugular vein of Donkey
No. II.
Small swelling at the seat of inoculation.
There is some tenderness in the swelling at the seat
of inoculation.
Swelling increased in size.
Swelling further increased in size.
Do.
do.
Swelling larger, and œdema spreads from right groin
to the left side of symphysis pubis.
13th.—Animal's left cheek and lower eyelid swollen ;
the swelling is circumscribed, and on manipulation
apparently contains a semi-fluid jelly.
Do.
do.
Do.
do.
16th.—Swelling of face entirely disappeared, and the
animal appears in perfect health. Appetite vora-
cious.
24th.—White corpuscles of the blood considerably
increased in number since yesterday.
25th.—Slight lacrymation ; otherwise the animal
appears healthy.
26th.—Animal weaker and unable to rise, breathing-
quickened (61 respirations per minute). The right
cornea is quite milky in appearance.
Urine passed involuntarily, turbid, Sp. gr. 1,008.
Slightly acid. Albumen 1/16th. Contains no hæma-
tozoa, although numerous specimens were examined
microscopically. 6 P.M. animal convulsed, fore limbs
extended and rigid ; and unconsciousness supervened.
Death took place at 9 P.M.
Autopsy at 3 A.M., 27th September 1892.
B 2236— 41 ap