160
Date.
1892.
October 4
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5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
Date of
Disease.
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
Temperature °C.
A.M.
40.8
40.5
40.4
40.4
40.7
40.1
39.8
40.2
40.6
40.3
40.1
40.4
40.0
40.2
40.2
40.6
38.7
P.M.
40.2
40.8
40.7
40.6
40.0
40.2
40.6
40.4
39.8
38.8
39.8
39.7
402
40.2
40.0
40.0
...
Hæatozoa
in Blood.
Few
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REMARKS.
5th.—Acute nasal catarrh, with frequent sneezing ;
conjunctivæ of upper lids considerably swollen
and œdematous, and lacrymal secretion mixed with
blood, containing hæmatozoa. Inguinal glands
continue enlarged, hard on manipulation. Appetite
ravenous.
6th.—
Do.
do.
9th.—Animal bright, swelling of head reduced.
12th. —Swollen and œdematous condition of left
eyelids, and base of left ear ; also whole of the left
hind limb is twice normal size, owing to the pre-
sence of œdema.
14th.—Left hind limb reduced in size, but condition
of eyelids unchanged.
15th.—Left hind limb normal in size, but left fore
limb has become elephantine in proportion owing to
œdema.
16th—Left fore limb reduced in size, and animal
active.
17th.—Left fore limb almost normal in size, slight
nasal catarrh still continues.
18th.—Right hind limb much swollen, and œdematous.
19th.—All limbs normal in size, appetite good, animal
lively.
20th.—Animal dull, and semi-somnolent. Death
took place at 10-30 A.M.
Autopsy.—Two hours post mortem.
Body-weight, 1,164 grammes; somewhat emaciated : limbs normal in size. On section, a layer of yellow jelly-
like exudation presents itself, lying in the subcutaneous tissue of the skin covering the neck and chest. There are
several dark-coloured lymphatic glands in each inguinal region, two of which present centres of caseation.
No fluid in the pleural cavities, or adhesions of the visceral and parietal pleuræ.
Lungs present a localized emphysema at the apices, pale pink, but no extravasations on their surface. On section,
tissues healthy.
The pericardium contains a small quantity of a light amber-coloured fluid.
Heart—Externally presents a pale appearance, but no sub-pericardial ecchymoses. The right side of the organ is
empty and flaccid, the left side contracted. On section, Right Auricle and Ventricle are empty, and present no patho-
logical changes. The Left Auricle and Ventricle are also empty, and present no pathological changes.
Abdominal Cavity.—There is no fluid in the cavity of the peritoneum. There are, however, several enlarged
glands lying on either side of the lumbar vertebræ ; two are brick-red in colour, and measure ¾" by 2/3".
Stomach.—Contracted ; on section, healthy.
Liver.—Large ; weight 107 grammes ; dark brown in colour ; capsule smooth. On section, blood flows from the
cut surfaces of the vessels, and the tissues present a perfectly healthy appearance.
Spleen.—Enlarged ; weight, 9 grammes ; otherwise healthy.
Kidneys.—Right, 9.5 grammes, Left, 9 grammes, capsules strip easily. Superficial capillary vessels injected. On
section, tissues appear healthy.
Intestines.—Healthy.
Bladder.—The urine removed was found to contain albumen ¼th.
Remarks.— This animal was inoculated subcutaneously on the 28th August 1892, with 0.5 c.c. of blood containing
very numerous hæmatozoa, taken from the jugular vein of Donkey No. II. The hæmatozoon, in this case, was originally
taken from the circulation of the Rat (mus decumanus) and passed through two Horses Nos. LXII and LXVII,
previous to the inoculation of the Donkey. No swelling of the neighbouring tissues followed inoculation, but the
glands in the inguinal region of the same side became enlarged, and a few days later a chain of small glands became
noticeable between the right mammary gland and symphysis pubis. On the fifth morning after inoculation, the
hæmatozoon was discovered swarming in the blood, although up to that time it had been absent. On the sixth day
following the first appearance of the organism in the blood, swelling and œdema of the right side of the face appeared;
this increased during the 7th and 8th days, accompanied by lachrymation on the same side; the secretion contained a
few hæmatozoa. On the day that the swelling and œdema decreased on the right side of the face it commenced to