71
Date.
1894.
June
9...
„
10...
„
11...
„ 12...
„ 13...
„ 14...
„ 15...
„ 16...
„
17...
„
18...
„
19...
„
20...
„
21...
„ 22...
„
23...
„ 24...
„
25...
„ 26...
„ 27...
„ 28...
„ 29...
„ 30...
July
1...
„
2...
„ 3...
„ 4...
„
5...
„ 6...
„ 7..
„
8...
„
9..
„ 10...
„ 11...
„
12...
„ 13...
„ 14...
„
15...
„ 16...
„ 17...
„ 18...
„ 19...
„
20...
„ 21...
„ 22...
„ 23...
„ 24...
Quan-
tity.
6,090
11,685
7,790
3,400
3,900
5,945
4,580
9,180
7,115
5,250
13,640
10,710
7,925
7,015
7,125
5,635
10,800
9,290
15,370
10,765
19,700
12,500
9,950
10,660
11,600
10,650
14,360
8,200
7,660
7,000
11,760
11,080
8,920
9,220
10,270
10,800
11,800
10,870
12,000
9,110
12,400
12,200
17,510
10,020
8,000
3,400
Colour.
Turbid
„ ..
„ ...
„
...
„ ...
„
...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„
„
„
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
Reaction.
Faintly
Acid.
Alkaline.
„ ...
„
...
Neutral .
Alkaline.
„
...
„ ...
„ ...
„
...
Acid
Alkaline.
„
...
„ ...
„ ...
„ ...
„ ...
„
...
„
...
Acid
„ ...
„
„ ...
„
...
„ ...
„ ...
„
...
Alkaline.
„ ...
„ ...
„ ...
Neutral...
Alkaline .
Faintly
Acid.
SI. Acid...
Acid
..
„
„
„
Specific
Gravity.
1,025
1,018
1,027
1,033
1,032
1,032
1,036
1,032
1,032
1,030
1,022
1,026
1,022
1,028
1,033
1,038
1,032
1,025
1,022
1,033
1,019
1,012
1,030
1,023
1,023
1,024
1,024
1,039
1,025
1,020
1,026
1,025
1,023
1,023
1,025
1,021
1,023
1,021
1,026
1,031
1,026
1,024
1,022
1,031
1,018
1,019
Albu-
men.
Gram-
mes.
Slightly
turbid.
„ ...
Clear...
Turbid.
„
...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ..
„ ...
„ ...
„ ...
„ ...
„ ...
7.26
6.39
3.82
Trace...
4.73
3.28
Turbid.
Trace...
„ ...
„
...
„ ..
„
..
„ ...
„
5.70
Trace...
„ ...
Nil ...
„ ...
Phos-
phates.
Nil ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„
...
„
„
...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„
„
„
...
„ ...
„ ...
Trace ,
„ ...
„ ...
„ ...
„ ...
„ ...
Heavy
Sedi-
ment.
Trace .
Nil . ...
„ ...
„
„ ...
„
„
Hip.
puric
Acid.
Gram-
mes.
Nil ...
If
„ ...
„
„ ...
„
„ ...
„ ...
„
...
„
...
„
...
„
...
,. ...
„
...
„ ...
„
...
„ ...
„
„
...
„
...
„ ...
„ ...
„
„
...
„
...
„ ....
„
Nil ...
„
„
„ ...
„ ...
Urea.
Gram-
mes per
100 c.c.
1.20
0.64
1.50
2.32
1.72
1.20
1.45
1.42
2.35
1.96
1.60
1.80
1.25
1.28
1.30
2.05
1.95
1.74
1.75
2.21
1.25
2.10
2.00
1.20
0.97
1.20
1.18
1.86
1.35
0.80
1.55
1.40
1.00
1.15
1.05
1.10
1.20
0.98
1.35
1.90
1.80
1.90
1.80
1.90
1.35
1.34
24th July 1894, Death at 7.15 A.M.
Total
Urea
excreted
in Urine
during
twenty-
four
hours.
Gram-
mes.
73.08
74.78
116.85
78.88
67.08
71.34
66.41
130.35
167.20
102.90
218.24
192.78
99.06
89.79
92.62
115.51
210.60
161.64
268.97
237.90
246.25
262.50
199.00
127.92
112.52
127.80
169.45
162.52
103.41
56.00
192.28
150.12
89.20
106.03
107.83
118.80
141.60
106.52
186.00
173.09
223.20
231.80
315.18
228.38
108.00
38.76
Water taken
during
twenty-four
hours.
Pints.Litres.
20=11.36
14= 7.98
16= 9.12
24=13.68
15= 8.55
16= 9.12
18=10.26
14= 7.98
18=10.26
20=11 .36
20=11.36
20=11.36
23=13.11
18=10.26
20=11.36
16= 9.12
23=13.11
22=12.54
28=15.96
24=13.68
25=14.25
20=11.36
20=11.36
29=16.51
24=13.68
32=18.24
29=16.51
24=13.68
20=11.36
20=11.36
14= 7.98
13= 7.41
14= 7.98
11= 6.27
4= 2.28
5= 2.85.
4= 2.28
0= 0.00
11= 6.27
10= 5.70
10= 5.70
9= 5.13
14= 7.98
7= 3.99
1= 0.57
0= 0.00
Ratio of
Urine passed
to Water
taken daily.
1 : 1.86
1 : 0.68
1 : 1.17
1 : 4.02
1 : 2.19
1 : 1.88
1 : 2.24
1 : 0.86
1 : 1.44
1 : 2.16
1 : 0.83
1 : 1.06
1 : 1.65
1 : 1.46
1 : 1.59
1 : 1.61
1 : 1.21
1 : 1.35
1 : 1.03
1 : 1.27
1 : 0.72
1 : 0.90
1 : 1.44
1 : 1.55
1 : 1.18
1 : 1.71
1 : 1.15
1 : 1.67
1 : 1.48
1 : 1.62
1 : 0.68
1 : 0.67
1 : 0.89
1 : 0.68
1 : 0.22
1 : 0.26
1 : 0.19
1 : 0.00
1 : 0.52
1 : 0.62
1 : 0.46
1 : 0.42
1 : 0.45
1 : 0.33
1 : 0.07
1 : 0.00
Ratio of
Urine
passed to
Water
drunk
during
periods of
Health
and
Disease.
}1 : 1.08
} 1 : 1.92
}1 : 1.53
}1 : 1.17
}1 : 1.28
}1 : 1.14
}1 : 1.03
}1 : 0.24
}1 : 0.44
}1 : 0.04
TEMPERATURE IN
SHADE
°F.
Maxi-
mum.
89.5
90.5
83.6
84.5
83.6
86.0
80.5
86.5
80.1
86.0
90.0
90.0
87.5
87.5
82.6
89.5
88.0
83.0
86.5
88.0
89.0
84.5
88.0
86.0
86.5
84.5
86.0
87.5
82.6
87.5
81.0
77.6
72.2
75.5
74.2
82.1
78.5
77.6
32.6
85.5
83.1
77.6
78.6
78.1
80.5
Mini-
mum.
73.8
72.9
68.9
71.4
70.4
70.4
72.9
72.4
71.4
72.4
72.9
73.8
73.4
71.4
72.4
71.9
70.9
71.9
72.4
70.9
70.9
72.4
71.9
70.9
70.9
70.9
71.4
70.9
70.9
70.4
70.4
69.4
69.9
68.4
68.9
70.9
68.9
69.9
71.4
70.9
69.9
70.9
70.9
70.1
69.4
Humi-
dity.
72
93
74
72
90
93
84
84
84
67
69
70
66
74
65
78
79
65
70
88
70
82
64
76
93
82
81
82
80
82
90
97
93
93
86
86
93
93
86
80
90
93
84
86
83
Donovan's
Solution
adminis-
tered daily
c. c.
c.c.
xxx
„
xxi
„
xviii
„ xxx
„
xxii
„
xxiv
„
xxvii
„
xxi
„
xxvii
„ XXX
„ xxx
„ xxx
„
xxx
„
xxii
„ XXX
„
xxiv
„ XXX
„
xxix
„
xlv
„ lx
„ lx
„ lx
„ lx
„ lx
Ar. Grs.. ii
c.c.
xlv
Ar. Grs. v
c.c.
xxx
Ar. Grs.vii
c.c.
xxv
Ar. Grs. ix
c.c.
xv
Ar. Grs. xii
„
xii
„ 2.5
„
xii
„ v.ss
„ 5.9
„ 2.0
„ 3.0
Dou.Sol.3.3
„
2.0
....
....
Ars. Grs. iv
„
v
Don.Sol.iiiss
Ars. Grp. iii
Don. Sol. iss
Ars. Grs. ½
......
......
......
Condition
of Blood.
Few.
Absent.
„
„
Few.
„
„
Absent.
„
„
Few.
„
„
„
„
Absent.
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
Few.
} Nume-
rous.
Very nu-
merous
„
Few.
Absent
...
Remarks.—For a period of seven days, this animal was kept under observation, and the physiological problems
relating to the ingestion and excretion of Nitrogen during health were investigated. The Double Iodides of Arsenic
and Mercury were then administered to the animal in increasing doses during a period of 46 days. A total of 158
grains of the tri-iodide of Arsenic and 158 grains of the bin-iodide of Mercury being given. On the evening of the day
upon which the Iodides were discontinued the animal was inoculated with 0.8 c.c. of blood containing swarms of hæma-
tozoa. The period of incubation lasted nearly 5 days, and then the animal passed through the ordinary phases of Surra,
but in this case in a less virulent form than even Horse No. XCVIII which underwent a preliminary treatment with
Arsenic. For the first fifty-four days of disease which lasted 59 days in all, the hæmatozoon never exceeded few in
the blood, but just before death rose to very numerous. So that there is no doubt that the preliminary treatment had
a marked effect upon the course of the malady.
The investigations commenced in health were continued throughout the disease, and the following data are now
recorded.