57
Table showing the amount and constituents of the daily urine throughout the different periods of Disease and Treatment.
Date.
1893
October,
„
"
"
November
„
„
„
„
„
„
„
„
„
18...
19...
20...
21...
22...
23...
24...
25...
26...
27...
28...
29...
30...
31...
1...
2...
3...
4...
5...
6...
7...
8.
9...
10..
11...
Quan-
tity
of urine
collect-
ed c. c.
...
1 ,800
720
5,090
2,950
2,640
2,640
3,000
3,420
5,500
4,310
5 040
5,2 40
4,210
3,170
3,450
2,300
2,050
2,460
1,350
3,180
2,375
3,000
2,958
4,700
Reaction.
...
Alkaline.
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
Specific
Gra-
vlry.
...
1,054
1046
1,022
3,032
1,052
1,054
1,048
1,046
],0?8
1,042
3,042
1,042
1,040
1,044
1,014
1,058
1.054
1,058
1,054
1,052
1,050
1,060
1,046
1,040
Albu-
men,
...
Nil
„
„
„
„
„
„
„
„
Trace.
Nil...
„
„
Trace.
Nil ..
„
„
Trace.
„
„
„
„
„
„
Phos-
phates.
..
Nil...
„
„
„
„
„
„
„„
„
„
„
„
„
„
„ „
„
„
„
„
„
„
„
„
Hippuric
Acid
Grammes.
...
20.6
12.24
0.00
5.09
4.05
44.88
36.00
23.94
...
...
...
...
..
32.87
3.45
4.40
4.02
41.82
14.85
43.60
40.37
24.00
29.50
0.00
Urea.
Grammes
per
100.c.c.
...
4.80
5.24
2. 0
2.80
3.70
3.00
3.00
3.20
2.35
4.50
5.20
5.10
5.10
5 20
4.90
4.60
4.70
4.90
4.6;
4.40
5.20
4.70
5.40
4.90
Death at 12- 10 P.M.
Total Urea
excreted
in the
Urine
during
24 hours.
Grammes.
...
86.40
37.72
106.89
82.60
97.68
79.20
90.00
109.44
129.25
193.95
262.08
277.24
214.71
164.84
169.05
105.80
96.35
120.54
62.10
139.92
123.50
14.00
159. 30
230.30
Water
drunk
daily
12 to 12
(noon).
Pints. Litres.
...
34=19.04
33=18.48
41¾=23-50
33½= 19.10
31=17.36
32½=18.20
32=1792
45=25.20
31=19.04
44=24.71
34=: 9.04
32=17.92
34=19.04
34=1304
34=19.04
33=18.48
33½=19.10
34=19.04
32=17.92
32=17.92
34=19.04
34=19.04
34=1904
17= 9.52
Ratio of
Urine
passed to
Water
drunk
daily.
1: 10.57
1 : 25.68
1 : 4.61
1 : 6.47
1 : 6.57
1 : 6->89
1 : 5.67
l : 7.40
1 : 3.46
1 : 5.73
1 : 3.77
1 : 3.42
1 : 4.52
1 : 6.00
1 : 5.52
1 : 8.03
1 : 9.31
1 : 7.74
1 : 13.27
1 : 5.63
1: 8.01
1: 6.35
1 : 6.45
1 : 2.38
Average in
Periods of
Health and
Discase,
...
}1 : 9 54
} 1:4.75
}1 : 7.77
}1: 5.76
Temperature
in Shade °P.
Maxi-
mum.
...
89.5
90.0
90.0
89.5
89.0
88.0
895
89.5
89.0
89.5
89.5
88.0
88.0
87.0
86 5
87.0
87.5
855
85.0
84.5
86.0
86.5
87 5
86.5
Mini-
mum,
60.4
57.4
57.9
57.4
56.9
57.4
59.4
57.9
58.4
59.4
59.9
57 4
55.9
56.4
56.4
55.4
53.3
57.4
58.9
69.4
66.4
66.4
644
66-9
Hu-
mi-
dity.
...
54
58
66
55
54
49
G5
69
59
65
66
52
48
49
40
41
52
48
53
71
71
80
81
75
Hæmatozoa in
the Blood.
Blood healthy.*
Absent.
„
„
„
„
„
„
Few.
Very numerous.
Swarming.
Very numerous
Very numerous
Absent.
„
„
„
„
„
„
„
„
„
„
„
*4 ounces of blood administered by mouth.
Autopsy. — Immediately after death.
The body is very emaciated.
Lungs.—There are several subpleural extravasations on the outer border of the right organ, about one inch in diameter.
On section, the tissues of both organs are found to be the seat of a geueral emphysema.
Pericardial Sac.—Contains about 6 ozs. of a reddish-coloured fluid.
Heart.—Weighs 5 lbs. 7 ozs. Tissues healthy in appearance.
Liver.—Weighs 6 lbs. 15 ozs. The convex surface is dotted over with small yellowish-white calcareous nodules and the
tissues are somewhat dark in colour. On section the tissues present a dark red appearance, and there are a number of calca-
reous nodules scattered through the substance of the organ.
Spleen.—Weighs 1 lb. 1 oz., pale in colour, both surfaces dotted over with bright red minute spots. On section the
tissues are soft and dark in colour.
Kidneys.—Right weighs 13½ ozs, the capsule strips easily, and there are a few petechiæ on the outer border. On section
the organ presents a healthy appearance. Left weighs 1 lb. ½ oz. The capsule strips easily, but there are no petechia visible
on the surface. On section healthy.
Stomach.—Contains a small amount of food. On section the i llous portion presents a tumour, about 1" in diameter,
from which on section a small quantity of red-coloured fluid exudes. The cuticular portion presents one large and several
small tumours in the substance of its walls, the former contains a yellowish jelly-like substance. The coats of the stomach
are contracted.
Small Intestines.—In parts, especially in the upper portion of the gut, the capillaries are injected, but for the most
part the mucous membrane presents a pale appearance.
Large Intestines.—Present a healthy appearance.
Bladder.—Contains 740 c.c. of a turbid, viscid and greenish yellow coloured urine. Alkaline in reaction. Specific
gravity 1,040.
Remarks.—This animal was also subjected to treatment by Arsenic immediately on the appearance of the Surra hæma-
tozoon. The Surra organizm appeared on the 26th October, the 8th morning after inoculation, and disappeared on the
morning of the 31st October, after which date it did not recur.
The Arsenical treatment was carried on until death occurred on the morning of the 11th November. In all 178 grains
of Arsenic in the form of Lq. Arsenicalis were administered.
The physiological problems bearing on the ingestion and egestion of Nitrogen, water, &c, will be discussed in Vol. III
together with the results of numerous other experimental cases. A few data with regard to the amount of urea, urine, and
water, are here recorded.
On reference to the Chart it will be observed, that the urea curve commenced to rise two days before the first appearance
of the hæmatozoon, and attained the maximum of 277 grammes of urea in the 24 hours, i. e., three times the normal
English excretion, three days after the temperature (10.6° C) was recorded, and did not reach the minimum of 62-10
grammes until six days after the disappearance of the organism from the blood. The daily averages of urine, urea, and water
drunk during the latent period, paroxysm and intermission were as follows :—
Latent period
Paroxysm
Intermission
Whole period
Urine
c.c.
2,691
4,702
2,933
3,231
Urea.
Grammes.
82.93
192.39
143.95
136.24
Water.
Litres.
19.36
21.54
18.31
19.29
Ratio of Urea
to Urine.
1 : 32.40
1 : 2440
I : 20.40
1 : 23.71
B 2236—15 ap