NationalLibraryOfScotland/medical-history-of-british-india huggingface dataset:
SURRA.
13
Arsenious Acid Injected Subcutaneously.
The subcutaneous method of administering arsenious
acid is not a suitable one. Even when highly diluted (1 in 1,000)
the injected fluid does not readily become absorbed and causes
a large œdematous swelling accompanied with pain and
inflammation which, in some cases, results in necrosis of the
skin.
Pony No. 5.—250 lbs. Was injected with 100 c.c. arsen-
ious acid (1 in 1,000). Swelling at seat of inoculation. Pony
was off feed for three days.
Mule No. 6.—427 lbs. Was injected with 500 c.c. arsen-
ious acid (1 in 1,000); 250 c.c. was injected on either side.
Large swellings at seat of inoculation resulted. The mule was
off feed for two days. After several days the skin sloughed
and the mule was destroyed.
Mule No. 1.—630 lbs. Was injected with 0.5 gms. arsen-
ious acid dissolved in 20 c.c. glycerine. Large swelling at
seat of inoculation, which persisted for several days. Slough-
ing of the skin followed.
Pony No. 8.—220 lbs. Received 0.75 gms. arsenious
acid dissolved in 50 c.c. of water containing 0.75 gms. sodium
bicarbonate. Died in 16 hours.
Arsenious Acid Injected Intravenously.
Mule No. 9.—549 lbs. Was injected with 100 c.c. of
arsenious acid (1 in 1,000). Showed no symptoms.
Mule No. 10.—550 lbs. Was injected with 500 c.c. arsen-
ious acid (1 in 1,000). Mule was off feed for two days.
Horse No. 11.—900 lbs. Was injected with 1 gm. arsenious
acid dissolved in 250 c.c. of water containing 1 gm. of sodium
bicarbonate. Symptoms of colic, followed after several days
by paralysis of hind quarters. Destroyed.
14
SURRA.
SOAMIN.
Soamin Administered by the Mouth.
Pony No. 12 received at the rate of 6 gms. per 500 lbs.
„
„
„
13
14
15
„
„
„
„
„
„
10
15
20
„
„
„
„
„
„
None showed any ill-effect.
Soamin Injected Subcutaneously.
Pony
No.
16
17
18
19
20
Weight.
lbs.
200
250
250
500
250
Dose.
gms.
2
3
4
10
5
Dose
per
500 lbs.
gms.
5
6
8
10
10
Results.
No symptoms.
Colic, off feed 4 days.
Died.
„
„
Toxic dose is about 10 gms. per 500 lbs.
ATOXYL.
Atoxyl Administered by the Mouth.
Pony No. 21.—Weight 229 lbs. Dose 2.29 gms. (5 gms.
per 500 lbs.). Slightly off feed for 2 days, no further symptoms.
Pony No. 22.—Weight 300 lbs. Dose 4.8 gms. (8 gms.
per 500 lbs.). Off feed for 3 days, no further symptoms.
Pony No. 23.—Weight 300 lbs. Dose 6 gms. (10 gms. per
500 lbs.). Died in. 17 hours.
The toxic dose is about 10 gms. per 500 lbs.
SURRA.
15
Atoxyl Injected Subcutaneously.
Pony
No.
24.
25
26
27
28
29
30
31
32
33
34
35
Weight.
lbs.
670
420
330
390
460
250
500
497
220
405
490
750
Actual dose.
gms.
6
5
4
5
7.5
5
10
11.18
5
10
13.25
21.28
Dose per
500 lbs.
gms.
4.47
5.95
6.06
6.41
8.15
10.0
10.0
11.24
11.36
12.34
13.52
14.18
Results.
Lived. No toxic effect.
„ „ „ „
„ „ „ „
Colic on 2nd day.
Death on 5th day.
Lived. No toxic effect.
Death on 4th day.
„ „ „ „
Death with colic in 33 hours 40
minutes.
Death following day.
Death early following morning.
The toxic dose is about 10 gms. per 500 lbs.
Atoxyl Injected Intravenously.
Pony
No.
36
37
38
39
40
41
42
43
44
Weight.
lbs.
360
283
630
630
564
678
574
565
678
Actual
dose.
gms.
1.20
1.00
4.00
4.00
4.00
7.50
7.50
7.50
10.00
Dose per
500 lbs.
gms.
1.66
1.76
3.17
3.17
3.54
5.53
6.53
6.63
7.37
Results.
Lived. No toxic effect.
„
„
„
Lived. Stood the dose on 4 conse
cutive days.
Lived.
Death.
„
„
The toxic dose is about 6 gms. per 500 lbs.
Having determined the approximate toxic dose of the
various arsenic preparations used, the results of administering
full sub-toxic doses were investigated. Attention was directed
to the following points:—
(1) The effect on trypanosomes and determination of
the period during which the blood remained
free from trypanosomes after single sub-toxic
dose of each drug.
16
SURRA.
(2) The influence on the health and general condition
of the animal.
(3) The comparison of the results produced by drugs
administered by various channels (subcutaneous-
ly, intravenously and by the mouth).
(4) The effect of varying the interval between succes-
sive doses.
(5) The effect of combining various arsenic prepara-
tions, also of using arsenic in conjunction with
other drugs.
The results are detailed in the data and tables following.
Treatment with Atoxyl alone.
The value of a single dose of atoxyl injected subcutaneously
has been estimated by the period during which the peripheral
circulation remained free from trypanosomes. The atoxyl
was administered at a period of paroxysm when the trypano-
somes were numerous in the blood.
Pony
No.
45
46
47
47
47
48
48
49
49
49
Weight.
lbs.
250
660
300
300
300
450
450
500
500
500
Dose.
c.c.
30
60
150
200
100
100
200
100
150
200
Per cent.
sol.
4
12
2
2
2
2
2
2
2
2
Period during which blood remain-
ed tree from trypanosomes.
9 days.
5
„
6 „
7 „
4 „
6 „
7 „
3 „
5 „
8 „
A full dose of atoxyl, injected subcutaneously, freed the
circulation from trypanosomes for three to nine days.
Effect of Atoxyl administered by the mouth.
The treatment was commenced when trypanosomes were
numerous in the blood.
SURRA.
17
Pony No. 50.—300 lbs. Received 4.8 gms. atoxyl in bolus
(8 gms. per 500 lbs.). Pony was off feed for three days. No
effect on trypanosomes. On seventh day received another
4 gms. atoxyl. No effect on trypanosomes. On ninth and
eleventh day 4 gms. atoxyl were given, the number of trypano-
somes in blood continued to increase. Treatment discontinued.
Pony No. 51.—229 lbs. Treatment commenced on 5th
day of disease. Received 2.29 gms. atoxyl in bolus (5 gms.
per 500 lbs.). Pony was off feed for two days. No effect on
trypanosomes.
Pony No. 52.—300 lbs. Received 6 gms. Atoxyl in bolus
(10 gms. per 500 lbs.). Pony died in 17 hours.
Atoxyl administered by the mouth is about five times
less toxic than arsenious oxide, but has no effect on the trypano-
somes in the blood.
Effect of Atoxyl injected subcutaneously.
A four per cent. solution of atoxyl was used except where
otherwise stated.
Pony No. 53.—240 lbs. (Intermittent dosage.)
1st day received 50 c.c.
3rd „
5th „
7th „
9th „
11th „
13th „
„
„
„
„
„
„
50 „
40 „
40 „
40 „
40 „
40 „
Trypanosomes disappeared on 2nd day, but reappeared
on 14th day.
Pony No. 54.—400 lbs. (Intermittent dosage.)
1st day received 50 c.c.
3rd „
5th „
7th „
9th „
„
„
„
50 „
50 „
50 „
50 „
Trypanosomes disappeared on 2nd day, but reappeared
on 11th day.
2
18
SURRA.
Pony No. 55.—564 lbs. (Continuous dosage.)
1st day received 50 c.c. 2 % sol.
2nd „
3rd „
4th „
5th „
6th „
7th „
8th „
9th „
10th „
11th „
12th „
13th „
14th „
„
„
„
„
„
„
„
„
„
„
„
„
„
50
50
50
50
50
100
100
100
100
100
100
100
100
„ „ „ „
„ „ „ „
„ „ „ „
„ „ „ „
„ „ „ „
„ „ „ „
„ „ „ „
„ „ „ „
„ „ „ „
„ „ „ „
„ „ „ „
„ „ „ „
„ „ „ „
Trypanosomes disappeared on the second day. reappeared
30 days after the treatment was discontinued.
Pony No. 56.—630 lbs. (Continuous dosage.)
Received 8 doses of 50 c. c. of 4% sol. on consecutive days.
Trypanosomes disappeared after the first dose, but re-
appeared 13 days after the last dose.
Effect of Atoxyl used Intravenously.
Pony No. 57.—500 lbs. (Continuous dosage.)
Received four injections of 50 c.c. of 2% sol. followed
by nine injections of 50 c.c. of. 4% sol. on consecutive days.
Trypanosomes disappeared after first dose, but reappeared
four days after last dose.
Pony No. 58.—560 lbs. (Intermittent dosage.) Received
7 doses of 50 c. c. of 4% solution on consecutive days. Inter-
val of six days followed by 4 doses of 50 c. c. of 8% solution
on consecutive days. Trypanosomes disappeared after first
dose but reappeared 29 days after the treatment was discon-
tinued.
Atoxyl alone, administered in non-toxic doses, either by
month, subcutaneously or intravenously, does not cure cases
of Surra.
SURRA.
19
ARSACETIN.
(Sodium Salt of Acetyl-Amino-Phenyl Arsenic Acid.)
This preparation is said to be much less toxic than the
atoxyl.
Pony No. 59.—250 lbs. Received subcutaneously 50 c.c.
of 4% solution. Died on 5th day.
Pony No. 60.—260 lbs. Injected 100 c.c. of 4% solution.
Died on 6th day.
Mule No. 61.—450 lbs. Injected 200 c.c. of 4% solution.
Died on 7th day.
Pony No. C 30.—310 lbs. Injected 200 c.c. of 4% solu-
tion. Off feed, colic, lying down, unable to rise. After nine
days the symptoms passed off and the animal recovered. This
pony was in an advanced stage of Surra (16 days of the disease)
and trypanosomes were numerous in the blood at the time of
treatment. The trypanosomes were absent from the circula-
tion next day. The animal has been kept under daily observa-
tion for 8½ months and shows no reappearance of the disease.
Arsacetin does not appear to be less toxic for the horse
than atoxyl.
TREATMENT WITH ARSENIOUS ACID ALONE.
Arsenious Acid administered in form of:—
Arsenious Acid (Bolus).
Loeffler & Rueh's Solution (Drench).
The effect of a single full dose administered at a period
of paroxysm:—
ARSENIOUS ACID (IN BOLUS).
Pony No. 62.—300 lbs., dose 1 gm.
The trypanosomes were absent from the circulation for
34 days.
Pony No. 63.—350 lbs., dose 1 gm.
Trypanosomes disappeared from the circulation for 14
days.
20
SURRA.
Pony No. 64.—300 lbs., dose 1 gm.
Trypanosomes disappeared from the circulation for ten
days.
Pony No. 65.—350 lbs., dose 1 gm.
Trypanosomes disappeared for 23 days.
Mule No. 66.—500 lbs., dose 2 gms.
Trypanosomes disappeared for ten days.
Pony No. C. 7.—300 lbs., dose 1 gm.
No return of trypanosomes. Kept under observation 5¼
months.
Pony No. 68.—300 lbs., dose 1 gm.
Trypanosomes disappeared for 21 days.
Pony No. 69.—300 lbs., dose 1 gm.
Trypanosomes disappeared for 14 days.
Pony No. 70.—281 lbs., dose 1 gm.
Trypanosomes disappeared from the circulation for 12
days.
ARSENIOUS ACID SOLUTION.
Pony No. 71.—225 lbs. Received 800 c.c. Trypanosomes
disappeared for ten days.
Mule No. 72.—500 lbs. Received 1,200 c.c. Ars. Ac.
Solution. Trypanosomes disappeared for five days.
ARSENIOUS ACID (CONTINUOUS TREATMENT).
Pony No. C. 8.—350 lbs. 1st paroxysm. 14th day of
disease.
1st day
3rd „
5th „
7th „
9th „
11th „
13th „
15th „
17th „
19th „
. .
. .
. .
. .
. .
. .
. .
. .
. .
. .
1 gm.
1 „
1.2 gms.
1.5 „
1.5 „
2
„
1 gm.
1
„
1 „
1 „
Arsenious Acid.
„
„
„
„
„
„
„
„
„
No return of trypanosomes. Kept under observation 3¼
months.
PLATE I.
FIG. 1.—C 30. CURED WITH ONE DOSE OF ARSACETIN.
FIG. 2.— C 31. CURED BY ONE DOSE OF SOAMIN.
Under observation for 8½ months after cessation of treatment.
PLATE II.
FIG. 3.—C 8. TREATED WITH ARSENIOUS ACID.
FIG. 4.-C 4.
SURRA.
21
Pony No. C. 4.—350 lbs. 3rd paroxysm. 20th day of
disease.
1st day
3rd „
5th „
7th „
9th „
. .
. .
. .
. .
. .
1 gm.
1 „
1
„
1 „
1 „
Treatment stopped as pony was off feed and had an attack
of colic. No return of trypanosomes. Kept under observa-
tion 3 months.
Pony No. C. 6.—300 lbs. 3rd paroxysm. 19th day of
disease.
1st day
3rd „
5th „
7th „
8th „
11th „
13th „
15th „
17th „
19th „
. .
. .
. .
. .
. .
. .
. .
. .
. .
. .
1 gms
1 „
1 „
1 „
1 „
1.5 gms.
1.5 „
1.5 „
1.5 „
2 „
No reappearance of trypanosomes. Kept under observa-
tion 10½ months.
Pony No. C. 3.—300 lbs. 4th paroxysm. 25th day of
disease. This pony had been previously treated by another
method which failed.
1st day
3rd „
5th „
7th „
9th „
11th „
13th „
15th „
. .
. .
. .
. .
. .
. .
. .
. .
1 gm.
1 „
1.2 gms.
1
gm.
1 „
1 „
1
„
1
„
No reappearance of trypanosomes. Kept under obser-
vation 3½ months.
Horse No. C. 1.—950 lbs. 3rd paroxysm. 17th day of
disease.
1st day
3rd „
5th „
. .
. .
. .
1 gm.
1.5 gms.
1.5 „
22
SURRA.
Horse No. C. 1.—contd.
7th day
9th „
11th „
13th „
. .
. .
. .
. .
2
gms.
2.5 „
2.5 „
3 „
After this last dose of 3 gms., the horse was off his feed
for three days and treatment was suspended for ten days.
24th day
26th „
28th „
. .
. .
. .
2 gms.
2
„
2
„
No reappearance of trypanosomes. Kept under obser-
vation 6 months.
Horse No. C. 2.—900 lbs. 3rd paroxysm. 19th day of
disease.
1st day
3rd „
5th „
7th „
9th „
11th „
l3th „
. .
. .
. .
. .
. .
. .
. .
1 gm.
1.5 gms.
1.5 „
2
„
2.5 „
2.5 „
3 „
After the last dose of 3 gms. the horse was off feed for
some days and treatment was suspended for ten days.
24th day
26th „
28th „
. .
. .
. .
2
gms.
2 „
2 „
No reappearance of trypanosomes. Kept under obser-
vation 6 months.
Pony No. C. 5.—250 lbs. 1st paroxysm. 6th day of
disease.
1st day
3rd „
5th „
7th „
9th „
11th „
13th „
15th „
17th „
10th „
. .
. .
. .
. .
. .
. .
. .
. .
. .
. .
1 gm.
1 „
1 „
1 „
1.25 gms.
17. „
1.25 „
1.25 „
1.25 „
1. 5 „
No reappearance of trypanosomes. Kept under obser-
vation 8 months.
PLATE III.
FIG. 5.-C 6.
FIG. 6.—C 3.
PLATE IV.
FIG. 7.-C 1.
FIG. 8.-C 2.
SURRA.
23
Pony No. C. 7.—300 lbs. 1st paroxysm. 6th day of
disease. 1st day 1 gm.
Pony was off feed for several days and no further treat-
ment was given. No return of trypanosomes. Kept under
observation 5¼ months.
Pony No. 78.—250 lbs. 2nd paroxysm. 15th day of
disease. Four doses of arsenious acid were given at intervals
of four days.
1st day
6th
„
11th
„
16th „
. .
. .
. .
. .
1 gm.
1 „
1 „
1 „
Trypanosomes reappeared 18 days after last dose.
Pony No. 79.—300 lbs. 2nd paroxysm. i2th day of disease.
Four doses of arsenious acid were given at intervals of one day
1st day
3rd „
5th
„
7th
„
. .
. .
. .
. .
1
1
1
1
gm.
„
„
„
Trypanosomes reappeared 21 days after last dose.
PREVENTIVE TREATMENT.
Pony No. 80.—400 lbs.
1st day
4th
„
. .
. .
1
gm.
4 „
Arsenious Acid.
„
After four days interval, was inoculated with Surra. Try-
panosomes appeared eight days after the inoculation.
Pony No. 81.—280 lbs.
1st day
3rd
„
. .
. .
50 c.c of 4% Atoxyl.
1.5 gms. Arsenious Acid.
After seven days interval, was inoculated with Surra.
Trypanosomes appeared six days after the inoculation.
Pony No. 82.—270 lbs.
1st day
6th
„
7th
„
10th „
15th „
. .
. .
. .
. .
. .
1
gm. Arsenious Acid.
0.5 gm.
„
Inoculated with Surra.
0.5 gm.
Arsenious Acid.
Inoculated with Surra.
Trypanosomes appeared on 17th day.
24
SURRA.
Pony No. 83.—230 lbs.
Treated as Pony No. 81.
Trypanosomes appeared 9th day.
Pony No. 84.—300 lbs.
Treated as Pony No. 82.
Trypanosomes appeared 12th day.
Mule No. 85.—450 lbs.
1st day received intravenously 100 c.c.
Arsenious Acid in solution (1 in 1,000).
5th day was inoculated with Surra.
11th day trypanosomes appeared in the circulation.
Mule No. 86.—500 lbs.
1st day 5 gms. arsenious acid dissolved in glycerine.
4th day was inoculated with Surra.
12th day trypanosomes appeared in the circulation.
ORPIMENT.
In these experiments chemically pure arsenious sulphide
was used.
Pony No. 73.—250 lbs.
trypanosomes.
Pony No. 74.—230 lbs.
disappeared for ten days.
Pony No. 75.—307 lbs.
disappeared for five days.
Pony No. 76.—416 lbs.
disappeared for eight days.
Pony No. 77.—523 lbs.
disappeared for seven days.
Received 6 gms.
Received 7 gms.
Received 8 gms.
Received 10 gms.
Received 10 gms.
No effect on
Trypanosomes
Trypanosomes
Trypanosomes
Trypanosomes
TREATMENT WITH ATOXYL AND ARSENIC.
Treatment was commenced at the first or second period
of paroxysm when trypanosomes were numerous in the circu-
lation. Freshly prepared four per cent. solutions of atoxyl
were used subcutaneously. Arsenious acid was administered
in bolus.
Several of the earlier experiments in which the animals
died from over-dosage are not here recorded.
PLATE V.
FIG. 9.—C 5.
FIG. 10.—C 7.
PLATE VI.
FIG. 11.—C 17.
FIG. 12.—C 15.
SURRA.
25
The first seven cases detailed are experiments in which
the treatment did not meet with success; the following nine
are cases where the result has been successful.
The atoxyl and arsenic were administered alternately,
leaving one day interval between each dose.
Pony No. 87.—300 lbs. 2nd paroxysm. 16th day of
disease. (intermittent dosage.)
1st day
3rd „
5th „
7th „
9th „
11th „
13th „
15th „
17th „
19th „
. . 50 c.c.
. . 0.5 gms.
. . 50 cc.
. . 0.5 gms.
. . 50 c.c.
. . 0.5 gms.
. . 50 c.c.
. . 0.5 gms.
. . 50 c.c.
. . 0.5 gms.
Atoxyl.
Arsenious Acid.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
The trypanosomes disappeared after the first dose. Re-
appeared four days after the treatment ceased. The dose
of arsenious acid was insufficient.
Pony No. 88.—600 lbs. 1st paroxysm. 4th day of disease.
(Intermittent dosage.)
1st day
3rd „
5th „
7th „
9th „
11th „
13th „
15th „
17th „
19th „
. . 50 cc.
. . 2 gms.
. . 75 c.c.
. . 3 gms.
. . 100 c.c.
. . 2 gms.
. . 100 c.c.
. . 2 gms.
. . 100 c.c.
. . 2 gms.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Trypanosomes disappeared from the circulation after
first dose, but reappeared seven days after last dose.
Pony No. 89.—500 lbs. 2nd paroxysm. 18th day of
disease. This pony had received previous treatment which
failed. (intermittent dosage.)
1st day
3rd „
5th „
. . 70 c.c.
. . 2 gms.
. . 100 c.c.
Atoxyl.
Ars. Ac.
Atoxyl.
26
SURRA.
Pony No. 89.—500 lbs.—contd.
7th day
9th „
11th
„
13th „
15th „
17th „
19th „
. . 1 gm.
. . 100 c.c.
. . 1 gm.
. . 100 c.c.
. . 1 gm.
. . 100 cc.
. . 1 gm.
Ars. Ac.
Aloxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Trypanosomes disappeared after the first dose, but re-
--peared eight days after the last dose.
Pony No. 90.—560 lbs. (Intermittent dosage.)
1st day
3rd „
5th
„
7th „
9th
„
11th „
13th
„
15th
„
17th „
19th
„
. . 50 c.c.
. . 0.5 gms.
. . 50 c.c.
. . 2 gms.
. . 75 c.c.
. . 2
gms.
. . 50 c.c.
. . 2 gms.
. . 50 c.c.
. . 2 gms.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Trypanosomes disappeared after the first dose, but re-
appeared 28 days after the last dose.
Pony No. 91.—280 lbs. 1st paroxysm. 6th day of
disease. (Intermittent dosage.)
1st day
3rd „
5th „
7th „
9th „
11th
„
. . 50 c.c.
. . 1 gm.
. . 50 c. c.
. . 1 gm.
. . 50 c.c.
. . 1.5 gms.
Atoxyl.
Ars. Ac.
Aloxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Trypanosomas disappeared after the first dose, but re-
appeared 21 days after the last dose.
Pony No. 92.—500 lbs. 1st paroxysm. 4th day of
disease. (Simultaneous dosage.)
1st day
2nd „
:3rd „
. . 40 c.c. of
. . 40 c.c „
. . 40 c.c. „
Atoxyl and 2 gms. of Ars. Ac.
„ „ 2 gms.
„ „ 2 gms.
„ „
„ „
Trypanosomes disappeared on 2nd day, but reappeared
nine days after the last dose.
PLATE VII.
FIG. 13.—C 16.
FIG. 14.—C 12.
PLATE VIII.
FIG. 15.—C 11.
FIG. 16.—C 9.
SURRA.
27
Pony No. 93.—300 lbs. 1st paroxysm. 5th day of disease.
(Simultaneous dosage.)
1st day
2nd „
3rd „
4th „
20 c.c.
. . 20 c.c.
. . 20 c.c.
. . 20 c.c.
Atoxyl and 1 gm. Ars. Ac.
„ „ „
„ „ „
„ „ „
Trypanosomes disappeared after first dose, but reappeared
twelve days after last dose.
In the above seven cases of failure, Pony No. 87 did not
receive sufficiently large doses of arsenious acid, a fact which
was recognised by the result of later experiments. Ponies
Nos. 89 and 90 had been previously treated with atoxyl alone
and the trypanosomes had acquired a resistance to this drug.
Pony No. 91 received six doses only which were not sufficient.
Ponies Nos. 92 and 93 were treated with atoxyl and arsenious
acid administered at the same time. This system did not meet
with any success.
In the following cases treatment has apparently effected a
cure.
Pony No. C. 11.—250 lbs. Fifth day after inoculation.
(Intermittent dosage.)
1st day
3rd „
5th „
7th „
9th „
11th „
13th „
15th „
17th „
19th „
. . 50 c.c.
. . 0.5 gms.
. . 50 c.c.
. . 0.5 gms.
. . 50 c.c.
. . 0.5 gms.
. . 50 c.c.
. . 0.5 gms.
. . 50 c.c.
. . 0.5 gms.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under observation four
months.
Horse No. C. 17.—About 900 lbs. Spontaneous case.
In an advanced stage of the disease when treatment was com-
menced. (Intermittent dosage.)
1st day
3rd „
5th „
7th „
. . 100 c.c. Atoxyl.
. . 1.5 gms. Ars. Ac.
. . 100 c.c. Atoxyl.
. . 1.5 gms. Ars. Ac.
28
SURRA.
Horse No. C. 17.— About 900 lbs.—contd.
9th day
11th „
13lh „
15th „
17th „
19th „
. . 100 c.c.
. . 1.5 gms.
. . 100 c.c.
. . 2 gms.
. . 100 c.c.
. . 2 gms.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Trypanosomes reappeared eleven days after the last dose.
A second treatment with increased doses was given. (Inter-
mittent dosage.)
1st day
3rd „
5th „
7th „
9th „
11th „
13th „
15th „
17th „
19th „
. . 125 c.c.
. . 3 gms.
. . 150 c.c.
. . 3 gms.
. . 150 c.c.
. . 3 gms.
. . 150 c.c.
. . 3 gms.
. . 150 c.c.
. . 3 gms.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Under observation 12
months.
Pony No. C. 15.—190 lbs. 1st paroxysm. 3rd day of
disease. (Intermittent dosage.)
1st day
3rd „
5th „
7th „
9th „
11th „
13th „
15th „
17th „
19th „
. . 30 c.c.
. . 1 gm.
. . 30 c.c.
. . 1 gm.
. . 30 c.c.
. . 1.5 gms.
. . 30 c.c
. . 1.5 gms.
. . 30 c.c.
. . 1.5 gms.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under observation
12 months.
Horse No. C. 16.—280 lbs. 1st paroxysm. 1st day of
disease. (Intermittent dosage.)
1st day
2nd „
4th „
6th „
8th „
10th „
. . 50 c.c.
. . 60 c.c.
. . 1.5 gms.
. . 50 c.c.
. . 1.5 gms.
. . 50 c.c.
Atoxyl.
„
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
PLATE IX.
FIG. 17.—C 10.
FIG. 18.—C 18.
PLATE X.
FIG. 19.—C 23.
FIG. 20.—C 24.
SURRA.
29
Horse No. C. 16.—280 lbs.—contd.
12th day
14th
„
16th
„
18th
„
. . 2 gms. Ars. Ac.
. . 50 c.c. Atoxyl.
. . 2 gms. Ars. Ac.
. . 50 c.c. Atoxyl.
No return of trypanosomes. Kept under observation
12 months.
Pony No. C. 15.—220 lbs. 1st paroxysm. 5th day of
disease. (Intermittent dosage.)
1st day
3rd „
5th „
7th „
9th „
11th „
13th „
15th „
17th „
19th „
. . 50 c.c.
. . 1 gm.
. . 50 c.c.
. . 1 gm.
. . 50 c.c.
. . 1 gm.
. . 50 c.c.
. . 1 gm.
. . 50 c.c.
. . 1 gm.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under observation
13 months.
Pony No. C. 12.—300 lbs. 1st paroxysm. 4th day of
disease. (Intermittent dosage.)
1st day
3rd „
5th „
7th „
9th „
11th „
13th „
15th „
17th „
19th „
. . 50 c.c.
. . 1 gm.
. . 50 c.c.
. . 1 gm.
. . 50 c.c.
. . 1 gm.
. . 50 c.c.
. . 1 gm.
. . 50 c.c.
. . 1 gm.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under observation
10 months.
Pony No. C. 14.—250 lbs. 1st paroxysm. 1st day of
disease. (Intermittent dosage.)
1st day
3rd „
5th „
7th „
9th „
11th „
13th „
. . 50 c.c.
. . 0.5 gm.
. . 50 c.c.
. . 0.5 gm.
. . 50 c.c.
. . 0.5 gm.
. . 50 c.c.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
Ars. Ac.
Atoxyl.
30
SURRA.
Pony No. C. 14.—250 lbs.—contd.
15th day
17th „
. . 50 c.c.
. . 0.7 gm.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under observation 14
months.
Mule No. C. 9.—300 lbs. 2nd paroxysm. 13th day of
disease. (Intermittent dosage.)
1st day
3rd
„
5th
„
7th „
9th
„
11th „
13th „
15th „
17th „
19th „
. . 50 c.c. Atoxyl.
. . 0.5 gm. Ars. Ac.
. . 50 c.c. Atoxyl.
. . 1 gm. Ars. Ac.
. . 50 c.c. Atoxyl.
. . 1.25 gms. Ars. Ac.
. . 50 c.c. Atoxyl.
. . 1.25 gms. Ars. Ac.
. . 50 c.c. Atoxyl.
. . 1.5 gms. Ars. Ac.
No return of trypanosomes. Kept under observation
7½ months.
Mule No. C. 10.—500 lbs. 2nd paroxysm. 13th day of
disease. (Intermittent dosage.)
1st day
3rd „
5th „
7th „
9th „
11th
„
13th „
15th
„
17th „
19th „
. . 50 c.c. Atoxyl.
. . 1.5 gms. Ars. Ac.
. . 50 c.c. Atoxyl.
. . 1.5 gms. Ars. Ac.
. . 60 c.c. Atoxyl.
. . 2 gms. Ars. Ac.
. . 60 c.c. Atoxyl.
. . 2 gms. Ars. Ac.
. . 60 c.c. Atoxyl.
. . 2 gms. Ars. Ac.
No return of trypanosomes. Kept under observation
7½ months.
In the following 16 experiments the atoxyl and arsenious
acid were administered on a different system.
A dose of arsenious acid in solution (Loeffler and Rueh)
in drench was administered at a period of paroxysm; this
was followed on consecutive days by a dose of atoxyl subcu-
taneously and a dose of arsenious acid in bolus. These three
doses were repeated once or twice at intervals of four days and
once after an interval of eight days. In a few instances the
intervals between the doses varied.
PLATE XI.
FIG. 21.—C 20.
FIG. 22.—C 29.
PLATE XII.
FIG. 23.—C 28.
FIG. 24.—C 25.