66
Remarks.—For a period of twenty-one days this animal was kept under observation, and the physiological problems
relating to the ingestion and excretion of Nitrogen during health were investigated. Arsenic was then administered
to the animal during the next fifty-four days, a total of 320.7 grains being given. On the evening of the' day on which
the Arsenic was discontinued, the animal was inoculated subcutaneously with 0.7 c.c. of blood containing swarms of
hæmatozoa. The period of incubation lasted 5.5 days, and then the animal passed through the ordinary stages of Surra,
but in a less virulent form than is usually met with, in naturally contracted cases..
It may be here noted that the animal was intolerant of Arsenic, and therefore instead of being able to administer doses
up to eight or nine grains twice in the 24 hours, only 5.9 grains daily were actually ingested, a quantity totally insufficient
to have any material effect on the hæmatozoon. It appears from our experience, that animals suffering from Surra have
a greater tolerance of Arsenic than healthy ones, when the drug is administered for a lengthened period as in the above
experiment. The investigations commenced in health were continued throughout the disease, and the following data
are now recorded :—
Health...
Preliminary Treatment Arsenic
Latent Period
Paroxysms
Intermissions
Whole Period
Average daily
Urine
cc.
3,163
2,851
2,482
6,039
3,976
3,750
Average Urea.
Grammes.
31.95
73.09
62.37
91.92
87.33
72-63
Average Water
drunk.
Litres.
21.050
10.340
12.540
7.440
7.370
11.000
Ratio of Urea
to Urine.
1 : 98.9
1 : 39.0
1 : 39.8
1 : 65.6
1 : 45.5
1 : 51.6
HORSE No. X
CIX.
Bay Australian Gelding, cast for age.
State on admission.—-The animal is in good condition. The visible mucous membranes are clear, the skin is cool. Temp.
37.4°C, P. 36, R. 12. The extremities are fine. The appetite is good and the excreta healthy in appearance.
This animal was also subjected to an experiment for the purpose of determining the efficacy of a drug, sufficient to
cause the full physiological effects, previous to submitting it to experimental inoculation with Surra. Further it was intended
to prosecute several interesting problems with regard to the ingestion and excretion of Nitrogen, urine and water during
health and the course of the disease (Surra) under treatment.
Date.
1894.
March
„
„
April
„
„
„
„
„
„
„
„
„
„
„
„
„
„
"
„
„
„
„
„
„
„
29...
30...
31...
1...
2...
3...
4...
5...
6...
7...
8...
9...
10...
11...
12...
13...
14...
15...
16...
17..
18..
19..
20..
21..
22..
23..
Temperature °C.
A.M.
...
...
...
...
...
...
37.4
37.3
37.3
37.4
37.5
37.3
37.0
37.5
37.3
37.6
37.7
37.6
37.6
37.5
37.8
37.6
37.5
37.3
38.0
37.5
1 P.M.
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
....
...
...
...
5 P.M.
...
...
...
...
...
37.6
37.4
37.7
37.7
37.5
37.5
37.8
37.5
37.6
37.6
37.8
37.7
37.7
37.6
37.6
37.7
37.5
37.6
37.5
37.6
37.6
Pulse.
A.M.
28
28
28
28
30
31
31
34
30
31
30
32
31
32
31
32
35
37
36
30
38
36
37
38
41
35
P.M.
29
28
29
32
30
31
31
30
32
32
31
31
32
31
34.
33
35
35
36
36
34
37
35
35
35
34
Respiration.
A.M.
25
24
12
16
19
15
26
23
24
14
19
16
20
25
23
16
23
27
31
32
34
24
38
27
26
35
P.M.
16
21
23
20
23
25
23
25
21
22
21
22
26
29
26
26
26
22
26
31
25
26
26
26
23
25
Day of
Disease.
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
„
...
Hæmatozoa
in the Blood.
......
REMARKS.
Conjunctival membranes con-
gested, no petechiæ
Do.
do.
Conjunctival membranes clear;
but two petechiæ in the left.
Conjunctival membranes clear.
Petechiæ fading.
Conjunctival membranes clear.
Do.
do.
no
petechiæ.
Do.
do.
Right conjunctiva slightly con-
gested ; left, clear.
Both conjunctivæ clear.
Do.
do.
Do.
do.
Do.
do.
Do.
do.
Right conjunctiva clear; left,
one spot.
Both conjunctivæ clear.
Left conjunctiva, one spot.
Do.
do.
Left conjunctiva traces of pete-
chiæ ; right, clear.
Right conjunctiva one spot;
left, clear.
Do.
do.
Both conjunctivæ clear.
Do.
Do.
Do.
Do.
Do.