NationalLibraryOfScotland/medical-history-of-british-india huggingface dataset:
20
Surra.
May 27th
„
29th
„ 31st
June 2nd
„ 4th
„ 6th
„ 8th
„ 10th
Aug. 31st
... 3 c.c. of 1% Atoxyl Tryps. absent.
... 13.5 mgms. of Orp.
„
„
... 3 c.c. of 1% Atoxyl
„
„
... 13.5 mgms. of Orp.
„
„
... 3 c.c. of 1% Atoxyl
„
„
... 13.5 mgms. of Orp.
„
„
... 3 c.c. of 1% Atoxyl
„
„
... 13.5 mgms. of
Orp.
„
„
... ... „ „
Body weight
in grammes.
1,010
1,010
970
940
910
880
860
900
1,520
RABBIT NO. 427.
May 17th
„
25th
„
25th
„
27th
„
29th
„ 31st
June 2nd
„
4th
„ 6th
„
8th
„ 10th
„ 12th
Aug. 31st
... Inoculated
with
Surra
...
... ... Tryps. appeared in blood
... 3 c.c. of
1%
Atoxyl
...
... 13 mgms. of Orp.
„
absent.
... 3 c.c. of 1% Atoxyl
„
„
... 13 mgms. of Orp.
„
„
... 3 c.c. of 1% Atoxyl
„
„
... 13 mgms. of Orp.
„
„
... 3 c.c. of 1% Atoxyl
„
„
... 13.5 mgms. of Orp.
„
„
.. 3 c.c. of 1% Atoxyl
„
„
... 13.5 mgms. of Orp.
„
„
... ... „
„
Body weight
in grammes.
...
...
1160
1220
1200
1200
1190
1160
1110
1100
1070
1100
1420
RABBIT NO. 424.
May 12th
„
20th
„
20th
„
22nd
„
24th
„
27th
„
29th
„ 31st
June 2nd
„ 4th
„ 6th
„ 8th
Aug. 31st
... Inoculated
with
Surra
... ...
... 3 c.c. of 1% Atoxyl
... 13.5 mgms. of Orp.
... 3 c.c. of 1% Atoxyl
... 13 mgms. of Orp.
... 3 c.c of 1% Atoxyl
... 13 mgms. of Orp.
... 3 c.c. of 1% Atoxyl
... 13 mgms of Orp.
.. 3 c.c. of 1% Atoxyl
.. 13.5 mgms of Orp.
.. ...
...
Tryps. appeared in blood.
...
„
absent.
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
Body weight
in grammes.
...
...
1250
1240
1170
1240
1220
1180
1160
1170
1150
1170
1650
The successful results of these experiments give hope that
the treatment may be of practical value in outbreaks of Surra
in India.
Surra.
21
In the nine cases, where the disease was in an early stage,
the treatment has apparently effected a cure. Whether an
equally good result can be obtained with animals in a later
phase of the disease has yet to be proved.
A large number of experiments have been made to decide on
the requisite dose of atoxyl.
Animal.
Mare ...
Pony ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
Mare ...
Age.
Aged
„
„
„
„
2 years
Aged
„
„
„
„
„
Body
weight
in lbs.
670
420
330
390
460
250
500
497
220
405
490
750
Injections Subcut.
Gms.
300 c.c. 2% = 6
250 c.c. 2% = 5
200 c.c. 2% = 4
250 c.c. 2% = 5
375 c.c. 2% = 7.5
250 c.c. 2% = 5
500 c.c. 2% = 10
559 c.c. 2% = 11.18
100 c.c. 5% = 5
500 c.c. 2% = 10
612.5 c.c. 2% = 13.25
1064 c.c. 2% = 21.28
Quantity
of Atoxyl
in gms.
per 500
lbs.
Gms.
4.47
5.95
6.06
6.41
8.15
10.0
10.0
11.24
11.36
12.34
13.52
14.18
Result.
Lived. No toxic effect.
„
„
„ „
„ „
„ „
Colic on 2nd day.
Death on 5th day.
Lived. No toxic effect.
Death on 4th day.
„ „
1 Death with colic in 33
hrs. 40 ms.
Death following day.
Death early following
morning.
Animal.
Pony ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
Age.
5½
9
Aged
Aged
6
6
Aged
8
6
Body
weight
in lbs.
360
283
630
630
564
678
574
565
678
Injections Intrav.
Gms.
30 c.c. 4% = 1.20
25 c.c. 4% = 1
50 c.c. 8% = 4
50 c.c. 8% = 4
50 c.c. 8% = 4
50 c.c. 15% = 7.5
50 c.c. 15% = 7.5
50 c.c. 15% = 7.5
50 c.c. 20% = 10
Quantity
of Atoxyl
per 500
lbs.
Gms.
1.66
1.76
3.17
3.17
3.54
5.53
6.53
6.63
7.37
Result.
Lived. No toxic effect.
„ „
„ „
„ „
Lived (stood the dose
on 4 consecutive
days).
Lived.
Death.
„
„
22
Surra.
Animal.
Guinea-pig ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
Weight
in gms.
500
470
380
390
420
200
420
200
370
270
392
400
410
410
400
Injections Subcut.
Gms.
3 c.c. 1% = .03
3 c.c. 1% = .03
3 c.c. 1% = .03
4 c.c. 1% = .04
5 c.c. 1% = .05
2.5 c.c. 1% = .025
6 c.c. 1% = .06
3 c.c. 1% = .03
2 c.c. 2% = .04
2 c.c. 2% = .04
3 c.c. 2% = .03
4 c.c. 2% = .08
5 c.c. 2% = .10
7.5 c.c. 2% = .15
10 c.c. 2% = .20
Quantity of
Atoxyl per
500 gms.
Gms. Cgms.
.030 = 3.0
.0319 = 3.19
.0394 = 3.94
.0512 = 5.12
.0595 = 5.95
.0625 = 6.25
.0713 = 7.13
0750 = 7.50
.0540 = 5.40
.074 = 7.40
.0765 = 7.65
.1000 = 10.00
.1219=12.19
.1829=18.29
.2500=25.00
Result.
Lived No toxic effect.
Death during
the
following night.
Lived. No toxic effect.
„ „
„ „
„ „
Death on 3rd day.
„
2nd day.
Lived. No toxic effect.
Died on 3rd day.
Died during following
night.
Died during morning
of following day.
Died evening of follow-
ing day.
Died in 26 hrs.
Died
the
following
morning.
Solutions of atoxyl up to 15 per cent. can be given
intravenously and subcutaneously without injury to the
tissue.
In our experiments we found that the lower dilutions
were preferable, as they were absorbed more readily and
caused less irritation at the seat of inoculation. For horses
a 4 per cent. solution and for small animals, a 1 per cent.
solution was adopted. The horse can tolerate 5½ gms. of
atoxyl per 500 lbs. body-weight, administered intravenously.
Subcutaneously somewhat less than double this amount can
be administered without any toxic effect.
In the guinea-pig 6 cgms. per 500 gms. body-weight is
the maximum amount which can be injected subcutaneously
with safety. In the treatment of Surra with atoxyl it is
not necessary to use large doses. About a quarter of the
toxic amount is sufficient. The dose should have the effect of
causing the trypanosomes to disappear from the peripheral
circulation.
If, on the day following the administration of atoxyl, the
trypanosomes still persist in the blood, the quantity of
atoxyl should be slightly increased and a second injection
made. The solutions of atoxyl should be freshly prepared.
The orpiment is best given in form of bolus and after the
animal has fed. Care must be taken that the ball or pill is
Surra.
23
not broken up in the mouth and that the drug is well mixed
with the other ingredients.
Throughout the treatment and for some weeks following,
the animal should receive a liberal diet and be protected
from extremes of temperature or any lowering condition.
(iii) FURTHER EXPERIMENTS ON THE TREATMENT
OF SURRA WITH ATOXYL AND ORPIMENT AND
OTHER PREPARATIONS OF ARSENIC.
THE object of these experiments was to confirm the
results of atoxyl and orpiment treatment published in a
previous paper* and to test the effect of this treatment when
commenced at an advanced stage of the disease.
In the case of some rabbits and guinea-pigs the treatment
was commenced about three weeks after the Surra inoculation
and two weeks after the appearance of trypanosomes in the
blood.
Unfortunately, it was not possible to adopt the same
course with the ponies. The only animals obtainable at the
time for experiment were worn out and half starved village
ponies which had no power of resistance to the disease and.
succumbed in a very short period. With these animals the
treatment was commenced, one to three and four days after
the trypanosomes were observed in the blood.
EXPERIMENTS WITH GUINEA-PIGS AND RABBITS.
Seven guinea-pigs and two rabbits received the atoxyl
and orpiment treatment and were kept under observation
for three months. In no instance did the trypanosomes re-
appear in the blood after the first injection of atoxyl. Four
of the guinea-pigs died during the period of observation.
These deaths were due to exposure to cold at night time and
to improper feeding. In the case of guinea-pig No. 287 seven
doses, in No. 288 six doses and in No. 289 four doses were
sufficient.
EXPERIMENTS WITH PONIES.
Summary.—Seven ponies Nos. 260, 245, 263, 283, 285,
282 and 280 were treated with atoxyl and orpiment given
alternately with an interval of one day between each dose.
* Journal of Tropical Veterinary Science, Vol. III, No. 4.
24
Surra.
In four cases Nos. 260, 245, 283 and 285 the treatment
has been successful.
In 263 the treatment failed and trypanosomes reappeared
in the blood.
Ponies 282, 280 (and four others not here recorded) died
under the treatment.
In the case of Pony 263 atoxyl and orpiment treatment
had no good result. Following this, atoxyl, orpiment and
tartar emetic were administered for 15 days and apparently
effected a cure.
Pony 287 was treated with tartar emetic and sodium
arsenite. After the treatment ceased, the trypanosomes again
appeared in the blood. A combination of atoxyl, orpiment and
sodium arsenite was then tried with success.
Pony 288 was treated with sodium arsenite (drench),
tartar emetic (intrav.) and orpiment (ball). This treatment
failed. When the pony was in an advanced stage of the
disease, the combination of sodium arsenite, atoxyl and
orpiment was administered with a successful result.
The same combinaton, atoxyl, orpiment and sodium
arsenite was administered to Pony 292. One injection of
atoxyl, 2 doses of sodium arsenite and 2 doses of orpiment
were given with a successful result.
In cases Nos. 258 and 265 the atoxyl and orpiment were
administered at the same time. The result was not good.
Following this the alternate method was tried but did not
succeed.
Pony 289 was treated with tartar emetic and orpiment.
He died under treatment.
The results of these experiments show that Surra in rab-
bits and guinea-pigs can be cured by a few doses of atoxyl
and orpiment administered according to the method of Lave-
ran and Thiroux even when the disease is well established
and that the treatment is accompanied with little risk.
That in ponies and horses the same treatment can effect
a cure even in advanced cases (Horse 245), but that it does
not succeed in all cases ; and that all animals cannot tolerate
the drugs. It is probable that further experiments may
Surra.
25
establish a more correct dose of orpiment and better methods
of administration.
That a combination of tartar emetic, atoxyl and orpi-
ment, and also a combination of atoxyl, orpiment and
sodium arsenite, can be used with success.
In the outbreak of Surra among the Native Cavalry two
advanced cases were treated by Lieut. Anderson, A.V.C. In
one case abscesses developed at the seat of the atoxyl inocula-
tion and the horse was destroyed. The second case, Horse
245, had a relapse after treatment. Larger doses of atoxyl
and orpiment were then administered with apparent success.
In a new series of experiments at present under observa-
tion, the combination of atoxyl, sodium arsenite and orpi-
ment has given results superior to any other treatment. The
drugs are administered on successive days and repeated twice
after an interval of four and eight days. The animals showed
no ill effects from the treatment and rapidly improved in con-
dition. At the present time (six weeks) there has been no
reappearance of the trypanosomes.
GUINEA-PIG NO. 277.
July 23rd
... Inoculated with Surra ......
Aug. 3rd
...
...
Tryps. appeared in blood
„
4th to 5th
...
„
present.
„
6th to 8th
...
„
absent.
„
9th to
14th
...
„
present
„ 14th
... 1.5 c.c. of 1% Atoxyl
„
„
„ 16th
... 9 mgms. of Orp.
„
absent.
„ 18th
... 1.5 cc. of 1% Atoxyl „ „
„
20th ... 9 mgms. of Orp. „ „
„
22nd
... 1.5 c.c. of 1% Atoxyl „ „
„
24th
...
9 mgms. of Orp. „ „
„
26th
...
1.5 c.c. of 1% Atoxyl „ „
„
28th
... 9 mgms. of Orp. „ „
„
30th
... l.5 mgms. of Orp. „ „
Sept.
1st
... 9 mgms. of Orp. „ „
Nov. 12th
...
...
„
„
Body weight
in grammes.
550
520
520
530
580
580
600
610
580
600
600
600
600
620
620
640
GUINEA-PIG NO. 278.
July 23rd
... Inoculated with Surra ......
„
31st
...
...
Tryps. appeared in blood
Aug. 1st to 9th
...
„
present
Body weight
in grammes.
600
600
500
26
Surra.
Aug.14th
„
16th
„
18th
„
20th
„ 22nd
„
24th
„ 26th
„
28th
„
30th
Sept. 1st
Nov. 12th
... 1.5 c.c. of 1% Atoxyl Tryps. present
... 9 mgms. of Orp. „ „
... 1.5 c.c. of 1% Atoxyl „ „
... 9 mgms. of Orp.
„
„
... 1.5 c.c. of 1% Atoxyl „ „
... 9 mgms. of Orp. „ „
... 1.5 c.c. of 1% Atoxyl „ „
... 9 mgms. of Orp. „ „
... 1.5 c.c. of 1% Atoxyl „ „
... 9 mgms. of Orp. „ „
... „ „
Body weight
in grammes.
490
500
500
500
500
500
500
490
500
500
500
GUINEA-PIG NO. 286.
Aug. 13th
„
25th
„
27th
„ „
„
28th
„
29th
„
30th
„ 31st
Sept. 1st
„
2nd
„
3rd
„
4th
„
5th
„
13th
„ 17th
... Inoculated with Surra blood from Guinea-Pig.
... Inoculated with Surra blood from Pony
...
...
Tryps. appeared in blood
... 1.5 c.c. of 1% Atoxyl „ „
... 9 mgms. of Orp.
„ absent
... 1.5 c.c. of 1% Atoxyl „ „
... 13.5 mgms. of Orp. „ „
... 1.5 c.c. of 1% Atoxyl „ „
... 9 mgms. of Orp „ „
... 1.5 c.c. of 1% Atoxyl „ „
... 9 mgms. of Orp.
„
„
... 1.5 c.c. of 1% Atoxyl
„
„
... 9 mgms. of Orp. „ „
... Feeds slowly. Temp. elevated „
Died of Pneumonia and Enteritis „
Body weight
in grammes.
600
600
600
620
610
620
610
620
620
620
620
620
740
600
GUINEA-PIG NO. 287.
Aug.14th
„ 21st
„ 21st
„ 22nd
„ 23rd
„ 24th
„ 25th
„ 26th
„ 27th
Oct. 7th
„ 10th
„ 30th
... Inoculated with Surra ......
... ...... Tryps. appeared in blood
... 1.5 c.c. of 1% Atoxyl
„
.....
... 9 mgms. of Orp.
„ absent
... 1.5 c.c. of 1% Atoxyl „ „
... 9 mgms. of Orp. „ „
... 1.5 c.c. of 1% Atoxyl „ „
... 9 mgms. of Orp. „ „
... 1.5 c.c. of 1% Atoxyl „ „
... ... ... „ „
... Feeds slowly. Temp. elevated „
... Died. Lesions of Pneumonia and Enteritis
Body weight
in grammes.
470
510
......
510
510
500
510
510
510
540
520
420
Surra.
27
GUINEA-PIG NO. 288.
Aug. 14th
„
19th
„
20th
„
21st
„
22nd
„
24th
„
26th
„
28th
„
30th
Oct.
14th
„
17th
„
26th
Inoculated with Surra ......
...... Tryps. appeared in blood
1.5 c.c. of 1% Atoxyl
„
present
..... „
absent
9 mgms. of Orp
„ „
1.5 c.c. of 1% Atoxyl „ „
9 mgms. of Orp
„ „
1 5 c.c. of 1 % Atoxyl „ „
9 mgms. of Orp. „ „
..... „
„
Feeds slowly. Temp. elevated „
Died. Lesions of Pneumonia and Enteritis
Body weight
in grammes.
390
430
430
440
440
450
440
440
450
570
470
350
GUINEA-PIG NO. 291.
Aug. 14th
„
21st
Inoculated with Surra ......
......
Tryps appeared in blood
„
22nd to 24th
„
present
„
24th
„
25th
„
26th
„
28th
„
30th
Sept.
27th
Oct.
1st
„
4th
1.5 c.c. of 1% Atoxyl
„ „
+ 9 mgms. of Orp.
..... „ absent
1.5 c.c. of 1% Atoxyl
„ „
+ 9 mgms. of Orp.
1.5 c.c. of 1% Atoxyl
„
„
+ 9 mgms. of Orp.
1.5 c.c. of 1% Atoxyl „ „
+ 9 mgms of Orp.
...... „
„
Off-feed. Temp. elevated „ „
Died from Peritonitis „ „
Body weight
in grammes.
500
530
530
530
520
520
510
510
610
570
470
GUINEA-PIG NO. 289.
Aug.
14th
„
22nd
„
22nd
„
24th
„
26th
„
28th
Nov.
12th
... Inoculated with Surra
...
... ...... Tryps appeared in blood
... 1.5 c.c. of 1% Atoxyl „ .....
... 9 mgms. of Orp.
„
absent
... 1.5 c.c. of 1% Atoxyl
„ „
... 9 mgms. of Orp
„
„
... ...... „ „
Body weight
in grammes.
500
520
520
500
500
510
500
RABBIT NO. 448.
July
23rd
... Inoculated with Surra
...
..
Aug.1st
...
......
Tryps. appeared in blood
„
2nd to 5th
......
„
present
Body weight
in grammes.
1600
1510
1500
28
Surra.
Aug.
14th
„ 16th
„
18th
„
20th
„
22nd
„
24th
„
26th
„
28th
„
30th
Sept. 1st
Nov. 12th
... 3 c.c. of 1% Atoxyl Tryps. present.
... 13.5 mgms of Orp.
„
„
... 3 c.c. of 1% Atoxyl
„
„
... 13.5 mgms. of Orp.
„
„
. 3 c.c. of 1% Atoxyl
„
„
... 13.5 mgms. of Orp.
„
„
... 3 c.c. of 1% Atoxyl
„
„
... 13.5 mgms. of Orp
„
„
... 3 c.c. of 1% Atoxyl
„
„
... 13.5 mgms. of Orp.
„
„
... ...... „ „
Body weight
in grammes.
1520
1530
1520
1520
1550
1600
1600
1580
1560
1580
1550
RABBIT NO. 449.
July
23rd
Aug.
1st
... Inoculated with Surra
...
......
Tryps. appeared in blood.
„
2nd to 5th
......
„
present.
„ 14th
„
16th
„
18th
„
20th
„
22nd
„
24th
„
26th
„
28th
„
30th
Sept. 1st
Nov.
12th
... 3 c.c. of 1% Atoxyl
„
absent.
... 13.5 mgms. of Orp.
„
„
... 3 c.c. of 1% Atoxyl „ „
... 13.5 mgms. of Orp
„
„
... 3 c.c. of 1% Atoxyl
„
„
... 13.5 mgms. of Orp.
„
„
.. 3 c.c of 1% Atoxyl
„
„
... 13.5 mgms. of Orp.
„
„
... 3 c.c. of 1 % Atoxyl
„
„
... 13.5 mgms. of Orp.
„
„
...
.....
„
„
Body weight
in grammes
1350
1360
1350
1350
1400
1350
1330
1320
1300
1280
1290
1300
1320
1400
Horse 245.—This horse belonged to a Native Cavalry Regi-
ment in which an outbreak of Surra occurred in July 1908.
He was observed to be wasting and anæmic. On examination,
his blood showed numerous trypanosomes.
Aug. 3rd ...
......
Tryps. observed in blood.
„
3rd ... 100 c c. of 1% Atoxyl
„
„
„
„
5th ... 1.5 gms of Orp.
„
absent.
„
7th ... 100 c.c. of 4% Atoxyl
„
„
9th ... 1.5 gms of Orp
„
„ 11th ... 100 c.c. of 4% Atoxyl
„
„
„
13th ... 1.5 gms of Orp.
„
„
„
15th ... 100 c.c. of 4% Atoxyl
„
„
„
17th ... 2.0 gms of Orp „ „
„
19th ... 100 c.c. of 4% Atoxyl „ „
„ 21st ... 2.0 gms. of Orp.
„ „
„ 22nd } Treatment discontinued. „ „
to 1st Sent.
Body weight
in lbs.
Not weighed
„
„
„
„
„
„
„
„
„
„
„
Surra.
29
Sept.
2nd
„
2nd
„ 2nd
„
4th
„
6th
„
8th
„
10th
„
12th
„
14th
„ 16th
„
18th
„ 20th
... ...... Tryps. reappeared
... Treatment with larger doses continued.
... 125 c.c. of 4% Atoxyl ......
.. 3.0 gms. of Orp.
Tryps.
absent.
.. 150 c.c. of 4% Atoxyl
„
„
... 3.0 gms. of Orp.
„
„
.. 150 c.c. 4% Atoxyl
„
„
... 3.0 gms. of Orp.
„
„
... 150 c
c of 4% Atoxyl
„
„
.. 3.0 gms. of Orp.
„
„
... 150 c.c. of 4% Atoxyl
„
„
... 3.0 gms. of Orp
„
„
Body weight
in lbs.
Not weighed.
„
„
„
„
„
„
„
„
„
„
Kept under daily observation up to the 31st January,
1909, during which time no trypanosomes were found in the
blood. The horse rapidly put on condition and appeared in
perfect health and was put to work.
PONY 263.
Aug. 7th Inoculated with Surra .. ...
„
15th
„
15th
„
16th
„
19th
„
21st
„
23rd
„
25th
„
27th
„
29th
„
31st
Sept. 2nd
Tryps. appeared in blood.
... 50 c.c. of 4% Atoxyl
„
present.
... 2.0 gms. of Orp :
„
„
... 75 c.c. of 4% Atoxyl
„
absent.
... 2.0 gms. of Orp.
„
„
... 100 c c. of 4% Atoxyl
„
„
... 2.0 gms. of Orp.
„
„
... 100 c.c. of 4% Atoxyl „
„
... 2.0 gms. of Orp
„
„
... 100 c.c. of 4% Atoxyl
„
„
... 2.0 gms. of Orp.
„
„
„
3rd to 8th Treatment discontinued
„
„
9th
„
9th
„
11th
„
13th
„
15th
„
16th
„
17th
„
18th
„
19th
„
20th
„
22nd
„
23rd
„
24th
„
28th
„
29th
„
30th
...
......
Tryps. reappeared.
... 150 c.c. of 4% Atoxyl ...
... 3.3 gms. of Orp.
Tryps. absent.
... 125 c.c. of 4% Atoxyl „
„
Treatment changed.
... 50 c.c. of 1% Tartar Emetic
„
... 2.0 gms. of Orp
„
... 100 c.c. of 4% Atoxyl
„
... 50 c.c. of 1% Tartar Emetic
„
... 2.0 gms. of Orp.
„
... 100 c.c. of 4% Atoxyl
„
... 50 c.c. of 1% Tartar Emetic
„
... 2.0 gms, of Orp.
„
... 100 c.c. of 4% Atoxyl
„
... 50 c.c. of 1% Tartar Emetic
„
... 2.0 gms. of Orp.
„
... 100 c.c. of 4% Atoxyl.
„
Body weight
in lbs.
...
...
...
640
655
658
663
665
670
666
670
665
...
...
675
...
...
...
...
...
670
670
672
670
675
693
711
718
725
30
Surra.
This pony was kept under daily observation for 3 months.
No trypanosomes were found in the blood and the animal was
kept at work after the first month and remains (January 31st,
1909) in apparent health and good condition.
PONY 283.
Sept. 11th
„
13th
„
20th
„
26th
„
26th
„ 27th
„
29th
Oct.
1st
„
3rd
„
5th
„
7th
„
9th
„
11th
„
13th
... 50 c.c. of 4% Atoxyl ...
... 1.5 gms. of Orp ... ...
... Inoculated with Surra ... ...
...
Tryps. appeared in blood
... 50 c.c. of 4% Atoxyl
„
„
...
60 c.c. of 4% Atoxyl „ present
... 1.5 gms. of Orp.
„
absent
... 50 c.c. of 4% Atoxyl
„
„
...
1.5 gms of Orp.
„ „
... 50 c.c. of 4% Atoxyl
„
„
... 2 gms. of Orp
„
„
.. 50 c.c. of 4% Atoxyl
„
„
... 2 gms, of Orp.
„
„
... 50 c.c. of 4% Atoxyl „ „
Body weight
in lbs.
280
......
285
270
270
266
274
273
272
281
283
273
276
Kept under observation up to January 31st, 1909. Showed
no return of trypanosomes and improved in condition.
PONY 285.
Sept. 12th ...
„ 19th ...
„
20th to 21st
„ 21st ...
„
23rd ...
„
25th ...
„
27th ...
„ 29th ...
Oct. 1st ...
„ 3rd ...
„ 5th ...
„ 7th ...
„ 9th ...
Inoculated with Surra
......
... Tryps. appeared in blood
... ...
„
present
30 c.c. of 4% Atoxyl
„
„
1
gm. of Orp.
„
absent
30 c.c. of 4% Atoxyl
„
„
1 gm. of Orp.
„
„
30 c
c
of 4% Atoxyl
„
„
1.5 gm. of Orp.
„
„
30 c c. of 4% Atoxyl
„
„
1.5 gm. of Orp.
„
„
30 c.c. of 4% Atoxyl
„
„
1.5 gm. of Orp.
„
„
Body weight
in lbs.
...
190
191
184
196
200
205
202
200
193
195
192
190
Kept under observation up to January 31st, 1909.
Showed no return of trypanosomes and improved in condition.
PONY 287.
Sept. 28th
Oct. 5th
„
5th
... Inoculated with Surra
....
... ... Tryps. appeared in blood
... 25 c c . of 1 % Tartar Emetic (intrav.) ...
Body weight
in lbs.
285
293
...
Surra.
31
Oct. 7th
„
9th
„
11th
„
13th
„
15th
„
17th
„
19th
„
21st
„
23rd
„
29th & 30th
„
30th
Nov. 2nd
.,
3rd
„
4th
„
9th
,. 10th
„ 12th
,. 18th
„ 19th
„ 20th
... 300 c.c. of Sodium Ar-
senite in drench.
... 25 c.c. of 1% Tartar
Emetic (intrav.)
... 300c c of Sodium Ar-
senite in drench
... 25 c.c of 1% Tartar
Emetic (intrav.).
... 300 c c of Sodium Ar-
senite in drench.
... 25 c.c of 1% Tartar
Emetic (intrav.)
... 30 c c. of Sodium Arsenite
in drench
... 25 cc of 1% Tartar
Emetic (intrav.)
... 200 c c. of Sodium Ar-
senite in drench.
..
... 40 c.c. of 1% Tartar
Emetic (intrav.) + 450
c.c. of Sodium Arsen-
ite in drench.
.. 600 c.c. of Sodium Ar-
senite in drench.
... 50 c.c. of 4% Atoxyl
... 2 gms. of Orp
. 600 c.c. of Sodium Arsen-
ite in drench.
... 50 c.c. of 4% Atoxyl
.. 2 gms. of Orp.
... 600 c.c. of Sodium Ar-
senite in drench
.. 40 c.c. of 4% Atoxyl
... 2 gms. of Orp.
Tryps.
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
absent.
„
„
„
„
„
„
„
„
reappeared
...
absent
„
„
„
„
„
„
„
„
Body weight
in lbs.
294
302
311
298
303
320
320
318
322
321
325
320
324
320
...
...
...
323
...
...
Kept under observation up to January 31st, 1909. Showed
no return of trypanosomes and improved in condition.
PONY 292.
Oct. 16th
„
23rd
„
24th
„
25th
„
26th
„
27th
... Inoculated with Surra
... ...
... 50 c.c. 4% Atoxyl
...
... 400 c.c. of Sodium Arsen-
ite in drench.
... 2 gms. of Orp.
Tryps.
„
„
„
„
......
appeared in blood
present
„
absent
„
Body weight
in lbs.
372
370
360
362
360
361
32
Surra.
Oct. 29th
„
31st
... 600 c.c. Sodium Arsen-
ite in drench.
... 2 gms. of Orp.
Tryps. absent.
Body weight-
in lbs.
358
356
Treatment discontinued as pony had an attack of colic
on 1st and 2nd of November.
This pony has been kept under daily observation for three
months, during which time no trypanosomes have appeared
in the blood. The pony remains (January 31st, 1909) in good
condition and apparent health.
PONY 288.
Sept. 28th
Oct. 5th
„
5th
„
6th
„
7th
„
11th
„
12th
„
13th
„ 18th
„
19th
„
20th
Nov. 5th
„ 6th
7th
„
20th
„
20th
„
21st
„
22nd
„
23rd
„
28th
„ 29th
Dec.
4th
„ 12th
„
14th
„
16th
... Inoculated with Surra. .....
Body weight
in lbs.
295
... ...... Tryps. appeared in blood 276
... 250 c.c. of Sodium Arsen- .....
ite in drench
... 25 c.c. of Tartar Emetic (intrav ) „
present.
... 1 gm. of Orp.
„
absent.
.. 300 c.c. of Sodium Arsen-
„
„
ite in drench
... 25 c.c. of Tartar Emetic (intrav.)
„
„
... 1 gm. of Orp.
„
„
. 300 c.c. of Sodium Arsen-
„
„
ite in drench.
... 25 c.c. of Tartar Emetic (intrav.)
„
„
... 1 gm. of Orp.
„
„
... ...... „
reappeared
... ...... „ present
...
......
„
absent.
... ...... „
reappeared
22nd
......
„
present.
.. 600 c.c. of Sodium Arsen-
„
„
ite in drench
... 40 c.c. of 4% Atoxyl
„
„
... 2 gms. of Orp.
„
absent.
... 600 c.c. of Sodium Arsen-
„
„
ite in drench.
... 40 c.c. of 4% Atoxyl
„
„
... 2 gms. of Orp.
„
„
... 400 c.c. of Sodium Arsen-
„
„
ite in drench.
... 40 c.c. of 4% Atoxyl
„
„
... 1 gm. of Orp.
„
„
.....
280
280
302
295
291
305
305
300
...
...
...
...
...
...
...
...
...
...
...
...
...
303
This pony was kept under daily observation up to 31st
January 1909. He improved in condition and showed no
return of the trypanosomes.