NationalLibraryOfScotland/medical-history-of-british-india huggingface dataset:
SURRA.
31
In some cases a dose of atoxyl subcutaneously was given
first, which cleared the circulation of trypanosomes within 24
hours.
This system of treatment has been the most successfu
of any tried. Out of 16 animals treated by this method, 12
were cured. In four cases the treatment failed: in three
instances, probably from insufficient doses and in one case
the interval between the doses was increased to six and
12 days.
All the animals stood the treatment well and rapidly
improved in condition.
Pony No. C. 18.—300 lbs. 1st paroxysm. 4th day of
disease.
1st day
3rd „
4th „
5th „
. . 40 c.c.
. . 300 c.c.
. . 30 c.c.
. . 1 gm.
Four days interval.
10th day
11th „
12th „
. . 300 c.c.
. . 30 c.c.
. . 1 gm.
Eight days interval.
21st day
22nd „
23rd „
. . 300 c.c.
. . 30 c.c.
. . 1 gm.
Atoxyl.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Trypanosomes appeared in the circulation four days after
the last dose.
A second course of treatment with increased doses was
given.
1st day
2nd „
3rd „
. . 400 c.c.
. . 50 c.c.
. . 1 gm.
Two days interval.
6th day
7th „
8th „
. . 400 c.c.
. . 50 c.c.
. . 1 gm.
Four days interval.
13th day
14th „
l5th „
. . 400 c.c.
. . 50 c.c.
. . 1.5 gms.
Eight days interval.
24th day
25th „
26th „
. . 400 c.c.
. . 60 c.c.
. . 2 gms.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
32
SURRA.
No return of trypanosomes. Kept under observation
7½ months.
Pony No. C. 23.—300 lbs. 2nd paroxysm. 13th day of
disease.
1st day
2nd „
3rd „
. . 500 c.c.
. . 50 c.c.
. . 1 gm.
Four days interval.
8th day
9th „
10th „
. . 500 c.c.
. . 50 c.c.
. . 1 gm.
Four days interval.
15th day
16th „
17th „
. . 500 c.c.
. . 50 c.c.
. . 1 gm.
Eight days interval.
26th day
27th „
28th „
. . 500 c.c.
. . 50 c.c.
. . 1 gm.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under observation
9 months.
Pony No. C. 24.—300 lbs. 2nd paroxysm. 13th day of
disease.
1st day
2nd „
3rd „
. . 500 c.c.
. . 50 c.c.
. . 1 gm.
Four days interval.
8th day
9th „
10th „
. . 500 c.c.
. . 50 c.c.
. . 1 gm.
Four days interval.
15th day
16th „
17th „
. . 400 c.c.
. . 50 c.c.
. . 1 gm.
Eight days interval.
26th day
27th „
28th „
. . 400 c.c.
. . 50 c.c.
. . 1 gm.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under observation 9
months.
Pony No. C. 20.—300 lbs. 4th paroxysm. 20th day of
disease.
PLATE XIII.
FIG. 25.—C 26.
FIG. 26.—C 21.
PLATE XIV.
FIG. 27.—C 22.
FIG. 28.—C 19.
SURRA.
33
This pony had been treated by another method without
success.
1st day
2nd „
3rd „
. . 600 c.c.
. . 40 c.c.
. . 2 gms.
Four days interval.
8th day
9th „
15th „
. . 600 c.c.
. . 40 c.c.
. . 2 gms.
Eight days interval.
23rd day
25th „
27th „
. . 400 c.c.
. .
40 c.c.
. . 1 gm.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under observation
nine and-a-half months.
Pony No. C. 29.—370 lbs. 1st paroxysm. 2nd day of
disease.
1st day
2nd „
3rd „
4th „
. . 50 c.c.
. . 400 c.c.
. . 50 c.c.
. . 2 gms.
Four days interval.
9th day
10th „
11th . .
. .
60 c.c.
. .
50 c.c.
. . 2 gms.
Atoxyl.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
No further treatment was given as the animal was off feed
and showed toxic symptoms. No return of trypanosomes.
Kept under observation eleven months.
Pony No. C. 28.—215 lbs. 2nd paroxysm. 13th day of
disease.
1st day
2nd „
3rd „
. . 400 c.c.
. . 50 c.c.
. . 1 gm.
Four days interval.
8th day
9th „
10th „
. . 300 c.c.
. . 40 c.c.
. . 0.5 gm.
Four days interval.
15th day
16th „
17th „
. . 300 c.c.
. . 40 c.c.
. . 0.75 gm.
Eight days interval.
26th day
27th „
28th „
. . 300 c.c.
. . 40 c.c.
. . 0.75 gm.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under observation
eight and-a-half months.
3
34
SURRA.
Pony No. C. 25.—260 lbs. 2nd paroxysm. 13th day of
disease.
1st day
2nd „
3rd „
. . 400 c.c.
. . 50 c.c.
. . 1 gm.
Four days interval.
8th day
9th „
10th „
. . 400 c.c.
. . 50 c.c.
. . 1 gm.
Four days interval.
15th day
l6th „
17th „
. . 300 c.c.
. . 40 c.c.
. . 0.75 gms.
Eight days interval.
26th „
27th „
28th „
. . 300 c.c.
. . 40 c.c.
. . 0.75 gms
Ars. Ac. sol.
Atoxyl.
Ars. Ac
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under observation
nine months.
Pony No. C. 26.—260 lbs. 2nd paroxysm. 13th day of
disease.
1st day
2nd „
3rd „
. . 500 c.c.
. . 50 c.c.
. . 1 gm.
Four days interval.
8th day
9th „
10th „
. . 500 c.c.
. . 50 c.c.
. . 1 gm.
Four days interval.
15th day
16th „
17th „
. . 400 c.c.
. . 50 c.c.
. . 1 gm.
Eight days interval.
26th day
27th „
28th „
. . 400 c.c.
. . 50 c.c.
. . 1 gm.
Ars. Ac sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac sol.
Atoxyl.
Ars. Ac
No return of trypanosomes. Kept under observation
nine months.
Pony No. C. 21.—245 lbs. 1st paroxysm. 5th day of
disease.
1st day
3rd „
4th „
5th „
. . 50 c.c.
. . 300 c.c.
. . 30 c.c.
. . 1 gm.
Four days interval.
10th day
11th
„
12th „
. . 300 c.c.
. . 30 c.c.
. . 1 gm.
Atoxyl.
Ars. Ac sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
SURRA.
35
Eight days interval.
21st day
22nd „
23rd „
. . 300 c.c.
. . 30 c.c.
. . 1 gm.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under observation
ten months.
Pony No. C. 22.—280 lbs. 2nd paroxysm. 8th day of
disease.
This pony had been under another treatment which failed.
1st day
2nd „
3rd „
Two days
6th day
7th „
8th „
. .
. .
. .
interval.
. .
. .
. .
500 c.c.
50 c.c.
1 gm
450 c.c.
50 c.c.
1 gm.
Two days interval.
11th day
12th „
13th „
. .
. .
. .
450 c.c.
50 c.c.
1 gm.
Four days interval.
18th day
19th „
20th „
. .
. .
. .
450 c.c.
50 c.c.
1 gm.
Eight days interval.
29th day
30th „
31st „
. .
. .
. .
400 c.c.
50 c.c.
1 gm.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under observation
eight months.
Pony No. C. 19.—240 lbs. 3rd paroxysm. 18th day of
disease.
1st day
2nd „
3rd „
. . 300 c.c.
. . 50 c.c.
. . 1 gm.
Six days interval.
10th day
11th „
12th „
. . 300 c.c.
. . 50 c.c.
. . 1 gm.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol
Atoxyl.
Ars. Ac.
Trypanosomes appeared nine days after last dose.
A second course of treatment was given.
1st day
2nd „
3rd „
. . 400 c.c.
. . 50 c.c.
. . 1 gm.
Ars. Ac. so
Atoxyl.
Ars. Ac.
36
SURRA.
Three days interval.
7th day
8th „
9th „
. .
. .
. .
400 c.c.
50 c.c.
1 gm.
Four days interval.
14th day
15th „
16th „
. .
. .
. .
400 c.c.
50 c.c.
1 gm.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
No return of trypanosomes. Kept under obs vation
nine months.
Pony No. C. 27.—270 lbs. 2nd paroxysm. 13th day of
disease.
1st day
3rd „
4th „
6th „
8th „
9th „
11th „
13th „
14th „
. . 50 c.c.
. . 600 c.c.
. . 1 gm.
. . 50 c.c.
. . 500 c.c.
. . 1 gm.
. .
50 c.c.
. . 500 c.c.
. . 1 gm.
Atoxyl.
Ars. Ac. sol.
Ars. Ac.
Atoxyl.
Ars. Ac. sol.
Ars. Ac.
Atoxyl.
Ars. Ac. sol.
Ars. Ac.
This pony was treated on a different system. The Ars.
As. sol. and Ars. As. in bolus were given on consecutive days
and the atoxyl alternately after one day interval.
No return of trypanosomes. Kept under observation
nine months.
Three other ponies treated by the same method showed
a return of the disease a few days after treatment ceased.
Pony No. 94.—300 lbs. 2nd paroxysm. 13th day of
disease.
1st day
2nd „
3rd „
. . 300 c.c.
. .
50 c.c.
. . 1 gm.
Four days interval.
8th day
9th „
10th „
. . 300 c.c.
. .
50 c.c.
. . 1 gm.
Eight days interval.
19th day
20th „
21st „
. . 300 c.c.
. .
50 c.c.
. . 1 gm.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Trypanosomes reappeared 30 days after last dose.
PLATE XV.
FIG. 29.—C 27.
FIG. 30.—C 32.
SURRA.
37
Pony No. 95.—300 lbs. 1st paroxysm. 4th day of
disease.
1st day ..
2nd „
3rd „ ..
Four days interval
8th day ..
9th „
10th „ ..
Eight days interval
19th day ..
20th „ ..
21st „ ..
300 c.c.
25 c.c.
1 gm.
300 c.c.
25 c.c.
1 gm.
300 c.c.
25 c.c.
1 gm.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Trypanosomes reappeared fourteen days after last dose.
Pony No. 96.—230 lbs. 1st paroxysm. 4th day of
disease.
1st day ..
2nd „ ..
3rd
„
..
Pour days interval
8th day ..
9th „ ..
10th „ ..
Eight days interval
19th day ..
20th „ ..
21st „ ..
300 c.c.
30 c.c.
1 gm.
.
300 c.c.
30 c.c.
1 gm.
300 c.c.
30 c.c.
1 gm.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Trypanosomes reappeared seven weeks after last dose.
Pony No. 97.—320 lbs. 3rd paroxysm. 21st day of
disease.
This pony had received other treatment without success.
1st day
..
50 c.c.
4th „
..
300 c.c.
5th „
50 c.c.
6th „
..
1 gm.
Six days interval.
13th day
..
300 c.c.
14th „
..
50 c.c.
15th „
..
1 gm.
Twelve days interval.
28th day
..
400 c.c.
29th „
..
50 c.c.
30th „
..
1 gm.
Atoxyl.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Ars. Ac. sol.
Atoxyl.
Ars. Ac.
Trypanosomes reappeared twelve days after last dose.
38
SURRA.
TREATMENT WITH SOAMIN.
Effect of a single dose.
Pony No. 98.—350 lbs. 1st paroxysm. 2nd day of dis-
ease. 60 c.c. of 4% Soamin subcutaneously.
Trypanosomes disappeared from the circulation for nine
days.
Pony No. 99.—407 lbs. 1st paroxysm. 3rd day of
disease. 60 c.c. of 4% Soamin subcutaneously.
Trypanosomes disappeared from the circulation for six
days.
Mule No. 100.—500 lbs. 1st paroxysm. 2nd day of
disease. 100 c.c. of 4% Soamin subcutaneously.
Trypanosomes disappeared from the circulation for twelve
days.
Pony No. 101.—250 lbs. 1st paroxysm. 4th day of
disease. 100 c.c. of 4% Soamin subcutaneously.
Pony died the following day.
Pony No. C. 31.—250 lbs. 3rd paroxysm. 22nd day of
disease. 100 c.c. of 10% Soamin subcutaneously.
The pony was off feed and unable to rise for several days
after which he gradually recovered. No reappearance of
trypanosomes. Kept under observation eight and-a-half
months.
Pony No. 102.—298 lbs. 2nd paroxysm. 12th day of
disease.
1st day ..
3rd „ ..
5th „ ..
7th „ ..
50 c.c. of 4 per cent. Soamin.
„ „ „
„ „ „
„ „ „
Pony was off feed and treatment was discontinued. Try-
panosomes reappeared 14 days after last dose.
Soamin administered by the mouth in large doses (20 gms.
per 500 lbs.) had no effect on the trypanosomes in the blood.
Continuous treatment by the same method had no influence
on the course of disease.
SURRA.
39
TREATMENT WITH MERCURY.
Mercury Alone.
Pony No. 103.—340 lbs. 1st paroxysm. 3rd day of
disease. Received 50 c.c. Hg. Cl 2 (1 in 1,000) subcutaneously.
Trypanosomes disappeared after the first dose, but reappeared
the following day and remained in the circulation for three days.
The treatment was continued, the pony received 50 c.c. Hg. Cl.
(1 in 1,000) for four consecutive days, followed by 20 c.c.
intravenously for twelve days.
Trypanosomes reappeared eight days after the treatment
ceased. They were absent during the second period of treat-
ment.
Pony No. 104.—560 lbs. A spontaneous case received for
treatment in an advanced stage of the disease. Received
three injections daily 50 c.c. Hg. Cl 2 (1 in 1,000) followed
by five injections daily of 35 c.c.
Trypanosomes reappeared in the circulation four days
after the treatment ceased. They were absent during the
period of treatment.
The subcutaneous injections were not well absorbed and
caused pain and swelling at the seat of injection. Calomel in
full and continuous doses had no effect on the course of the
disease. It was tested in several cases.
The combination of atoxyl and mercury was also tested,
but the results were inferior to those obtained by the use of
atoxyl alone.
Mercury and Atoxyl.
Pony No. 105.—600 lbs. Spontaneous case received for
treatment. Was in an advanced stage of the disease. Re-
ceived on alternate days 50 c.c. of 8% atoxyl and 20 c.c. Hg.
Cl 2 (1 in 1,000) both intravenously. Trypanosomes disap-
peared after the first dose. The treatment was continued for
fifteen days but had little effect on the course of the disease.
Trypanosomes reappeared in the circulation five days after
the treatment ceased.
40
SURRA.
Pony No. 106.—300 lbs. 4th paroxysm. 24th day of
disease. Had been treated by another method which failed.
The pony was treated for four months with atoxyl and mercury
administered intravenously. A total amount of 150 c.c. of
4% atoxyl and 95 c.c. of Hg. Cl., (1 in 1,000) was given. The
treatment had little effect.
TREATMENT WITH ANTIMONY SALTS.
Potassium Antimonyl Tartrate.
Pony No. 107.—Body weight 600 lbs. 2nd paroxysm.
100 c.c. of 1% solution.
Trypanosomes were absent from the blood for seven
days.
Pony No. 108.—Body weight 600 lbs. 3rd paroxysm.
100 c.c. of 1% solution.
Trypanosomes were absent from the circulation for nine
days.
Pony No. 109.—Body weight 630 lbs. 4th paroxysm.
25th day of disease.
This pony was treated for six weeks receiving at intervals
intravenous injections of potassium antimonyl tartrate 1%
solution. The total amount administered was 9.2 gms.
During the treatment the pony improved in condition
and the circulation remained free from trypanosomes. The
trypanosomes reappeared in the blood three weeks after the
treatment ceased. Potassium antimonyl tartrate administered
in bolus, had no influence on the course of the diesase.
TARTAR EMETIC AND MERCURY.
Pony No. 110.—Body weight 260 lbs. 3rd paroxysm.
21st day of disease—
1st day
2nd „
3rd „
4th „
5th „
50 c.c. of 1% Tartar Emetic intrav.
20 c.c. (1—1,000) Hg. Cl 2
„ „ „ „
„ „ „ „
50 cc. of 1% Tartar Emetic
„
SURRA.
41
6th day
7th „
8th „
9th „
10th „
11th „
..
20 c.c. (1—1,000) Hg. Cl 2
.. „ „ „
.. „ „ „
.. „
„
„
.. „ „ „
.. „ „ „
inrav.
„
„
„
„
„
Trypanosomes were absent from the blood from 2nd to
11th day.
Reppeared on 12th day.
Pony No. 111.—Body weight 250 lbs. 3rd paroxysm.
15th day of disease—
1st day ..
2nd „ ..
3rd „ ..
4th „ ..
5th „ ..
6th „ ..
7th „ ..
8th „ ..
9th „ ..
50 c.c. of 1% Tartar Emetic inrav.
20 c.c. (1—1,000) Hg. Cl 2 „
„ „ „ „
„ „ „ „
„ „ „ „
„ „ „ „
50 c.c. of 1% Tartar Emetic „
„ „ „ „
100 c.c. „ „ „
Trypanosomes were absent from the blood 2nd to 9th
day. Reappeared 17 days after the treatment ceased.
TARTAR EMETIC AND ATOXYL.
Pony No. 112.—Body weight 600 lbs. 1st paroxysm.
5th day of disease—
1st day ..
3rd „ ..
5th „ ..
7th „ ..
9th „ ..
11th „ ..
50 c.c. of 4% Atoxyl.
1 grm. of Tartar Emetic in bolus.
50 c.c. of 4% Atoxyl.
1 grm. of Tartar Emetic in bolus.
50 c.c. of 4% Atoxyl.
1 grm. of Tartar Emetic in bolus.
Trypanosomes were absent from 2nd to 11th day. Re-
appeared on 12th day.
Pony No. 113.—Body weight 300 lbs. 2nd paroxysm.
13th day of disease.
This pony was treated with Tartar Emetic and Atoxyl
for a period of six weeks, receiving—
200 c c. of 4%
620 c.c. of 1%
525 c.c. of 2%
Atoxyl intravenously.
Tartar E.
„
Tartar E.
„
The animal improved in condition and the trypanosomes
were absent from the blood during the period of treatment.
42
SURRA.
A month after the treatment was discontinued the parasites
reappeared in the circulation.
TARTAR EMETIC AND ARSENIOUS ACID SOLUTION.
Arsenious Acid (Loeffler and Rueh's solution) was given
in drench, and Tartar Emetic 1% solution was given intra-
venously.
Pony No. 114.—Body weight 300 lbs. 1st paroxysm.
3rd day of disease—
1st day ..
3rd „ ..
5th „ ..
7th „ ..
9th „ ..
11th „ ..
13th „ ..
15th „ ..
17th „ ..
19th „ ..
25 c.c. Tartar Emetic.
300 c.c. Ars. Ac. sol.
25 c.c. Tartar Emetic.
300 c.c. Ars. Ac. sol.
25 c.c. Tartar Emetic.
300 c.c. Ars. Ac. sol.
25 c.c. Tartar Emetic.
300 c.c. Ars. Ac. sol.
25 c.c. Tartar Emetic.
300 c.c. Ars. Ac. sol.
The trypanosomes were absent during the period of treat-
ment, but reappeared six days after the last dose.
TARTAR EMETIC, ATOXYL AND ARSENIOUS ACID.
Pony No. C. 32.—Body weight 660 lbs. 2nd paroxysm.
24th day of disease.
This animal had received other treatment which failed.
Atoxyl was given subcutaneously, tartar emetic intravenously
and arsenious ac. in bolus—
1st day ..
3rd „ ..
5th „ ..
6th „ ..
7th „ ..
8h „ ..
9th „ ..
10th „ ..
12th „ ..
13th „ ..
14th „ ..
18h „ ..
19th „ ..
20th „ ..
21st „ ..
150 c.c. of 4% Atoxyl.
2 grms. of Ars. Ac.
125 c.c. of 4% Atoxyl.
50 c.c. of 1% Tartar Emetic.
2.0 grms. of Ars. Ac.
100 c.c. of 4% Atoxyl.
50 c.c. of 1% Tartar Emetic.
2.0 grms. of Ars. Ac.
100 c.c. of 4% Atoxyl.
50 c.c. of 1% Tartar Emetic.
2.0 grms. of Ars. Ac.
100 c.c. of 4% Atoxyl.
50 c.c. of 1% Tartar Emetic.
2.0 grms. of Ars. Ac.
100 c.c. of 4% Atoxyl.
SURRA.
43
No reappearance of trypanosomes in the blood after the
second day.
Kept under observation for 12 months. The curative
effect was probably due to the atoxyl and arsenious acid.
TARTAR EMETIC, ARSENIOUS ACID SOLUTION AND ARSENIOUS
ACID.
Arsenious acid (1 in 1,000) solution was given in drench,
Arsenious acid in bolus and tartar emetic 1% solution intra-
venously.
Pony No. 115.—Body weight 280 lbs. 1st paroxysm. 7th
day of disease.—
1st day ..
2nd „ ..
3rd „ ..
7th „ ..
8th „ ..
9th „ ..
10th „ ..
11th „ ..
250 c.c. Ars. Ac. sol.
25 c.c. Tartar Emetic.
1.0 grm. Ars. Ac.
300 c.c. Ars. Ac. sol.
25 c.c Tartar Emetic.
900 c.c. Ars. Ac. sol.
25 c.c. Tartar Emetic.
1.0 grm. Ars. Ac.
Trypanosomes were absent from the blood during period
of treatment. They reappeared 15 days after the last dose.
SODIUM ANTIMONYL TARTRATE.
Pony No. 116.—Body weight 250 lbs. 1st paroxysm. 50
c.c. of 1% solution intravenously.
Trypanosomes were absent from the blood on following
day. They reappeared after eight days.
Pony No. 117.—Body weight 260 lbs. 1st paroxysm.
50 c.c. of 1% solution intravenously.
Was off feed and suffered from colic same and following
day. Trypanosomes were absent from the blood for five
days.
Mule No. 118.—Body weight 500 lbs. 1st paroxysm.
100 c.c. of 1% solution intravenously.
Trypanosomes were absent for six days.
Pony No. 119.—Body weight 240 lbs. 1st paroxysm. 150
c.c. of 0.5% solution subcutaneously.
44
SURRA.
Animal was off feed for 2 days. Swelling and heat at
the seat of inoculation for several days.
Trypanosomes were absent for five days.
Pony No. 120.—Body weight 260 lbs. 1st paroxysm. 100
c.c. of 1% solution subcutaneously.
The dose was followed by colic, diarrhœa, and swelling
at the seat of inoculation. Thickening of the skin. Symptoms
persisted for several days.
Trypanosomes were absent for six days.
ANILINE ANTIMONYL TARTRATE.
Pony No. 121.—Body weight 250lbs. 1st paroxysm. 100
c.c. of 1% solution subcutaneously.
Swelling and heat at seat of inoculation.
Trypanosomes were absent from the circulation for eight
days.
Pony No. 122.—Body weight 270 lbs. 1st paroxysm. 100
c.c. of 1% solution subcutaneously.
Off feed, dull, swelling at seat of inoculation.
After 6 days the skin sloughed.
Trypanosomes were absent for nine days.
LITHIUM ANTIMONYL TARTRATE.
Pony No. 123.—Body weight 400 lbs. 1st paroxysm. 50
c.c. of 1% solution intravenously.
Trypanosomes were absent for four days.
Pony No. 124.—Body weight 260 lbs. 1st paroxysm. 100
c.c. of 1% solution intravenously.
Fed slowly and had colic on the following day.
Trypanosomes were absent for nine days.
Pony No. 125.—Body weight 400 lbs. 2nd paroxysm. 100
c.c. of 1% solution subcutaneously.
Off feed. Swelling and pain at the seat of inoculation.
Trypanosomes were absent for four days.
Pony No. 126.—Body weight 200 lbs. 1st paroxysm. 100
c.c. of 1% solution subcutaneously.
SURRA.
45
Off feed. Swelling and pain at the seat of inoculation
followed by necrosis of the skin.
Trypanosomes were absent for nine days.
LIST OF SURRA ANIMALS WHICH HAVE SHOWN NO RETURN OF
THE DISEASE AFTER TREATMENT.
The date of disease at which treatment was commenced
is reckoned from the day on which trypanosomes appeared in
the circulation.
The period of observation is dated from the completion
of the treatment.
All the animals mentioned in the list are still alive, and
in good condition and health, and no trypanosomes have been
observed in their blood for the periods mentioned. Daily
examinations of the blood were made.
No. of Animal.
No.
Horse C. 1 .. ..
„ C. 2 .. ..
Pony C. 3 .. ..
„ C. 4 .. ..
„ C. 5 .. ..
„ C. 6 .. ..
„ C. 7 . .. ..
„ C. 8 .. ..
Day of
disease.
17th
19th
25th
20th
6th
19th
6th
14th
Paroxysm.
3rd
3rd
4th
3rd
1st
3rd
1st
1st
Drugs used.
Ars. Ac. alone.
„
„
„
„
„
„
„
(FIRST METHOD OF DOSAGE.)
Mule C. 9 .. ..
„ C. 10 .. ..
Pony C. 11 .. ..
„ C. 12 .. ..
„ C. 13 .. ..
„ C. 14 .. ..
„ C. 15 .. ..
„ C. 16 .. ..
Horse C. 17 .. ..
13th
12th
5th
4th
5th
1st
5th
1st
Spontaneous
case in ad-
vanced stage.
2nd
2nd
..
1st
1st
1st
1st
1st
..
Atoxyl and
Ars. Ac.
„
„
„
„
„
„
„
„
(SECOND METHOD OF DOSAGE.)
Pony C. 18 .. ..
„ C. 19 .. ..
„ C. 20 .. ..
„ C. 21 .. ..
„ C. 22 .. ..
4th
18th
20th
5th
8th
1st
3rd
4th
1st
2nd
Atoxyl and
Ars. Ac.
„
„
„
„
Period under
observation.
6 months.
6 „
3½ „
3
„
8 „
10½ „
5¼ „
3¼ „
7½ months.
7½ „
4
„
10 „
10 „
14 „
12
„
12
„
12
„
7½ months.
9 „
9½ „
10 „
8
„
46
SURRA.
(SECOND METHOD OF DOSAGE)—(contd.)
No. of Animal.
Pony C. 23 .. ..
„ C. 24 .. ..
„ C. 25 .. ..
„ C. 26 .. ..
„ C. 27 .. ..
„ C. 28 .. ..
„ C. 29 .. ..
„ C. 30 .. ..
„ C. 31 .. ..
„ C. 32 .. ..
Day of
disease.
13th
13th
13th
13th
13th
13th
2nd
21st
22nd
24th
Paroxysm.
2nd
2nd
2nd
2nd
2nd
2nd
1st
3rd
3rd
2nd
Drugs used.
Atoxyl and
Ars. Ac.
„
„
„
„
„
„
Arsacetin.
Soamin.
Atoxyl, Tartar
Emetic and
Ars. Ac.
Period under
observation.
9 months.
9 „
9 „
9 „
9 „
8½ „
11 „
8½ „
8½ „
12 „
A SUMMARY SHOWING THE COMPARATIVE VALUE OF THE PRE-
PARATIONS EXPERIMENTED WITH IN CLEARING THE PERI-
PHERAL CIRCULATION FROM
TRYPANOSOMES.
A single dose of each preparation was given when the
trypanosomes were numerous in the blood and on the 1st or
2nd day of paroxysm. Except where otherwise stated the
parasites were absent from the circulation the day following
the administration of the dose.
The effect of the drug was estimated by the period during
which the blood remained free from trypanosomes.
ATOXYL.
No. of
Animal.
Pony
„
„
„
„
Mule
„
,.
„
Pony
„
„
„
127 ..
128 ..
129 ..
130 ..
131 ..
132 ..
133 ..
134 ..
135 ..
136 ..
137 ..
Weight
in lbs.
250
280
350
300
450
500
600
660
300
229
300
Amount of Drug.
30 c.c. of 4%
30 „ of 4%
200 „ (Arsacetin)
100 „ of 2%
150 „ of 2%
200 „ of 2%
100 „ of 2%
200 „ of 2%
100 „ of 2%
150 „ of 2%
200 „ of 2%
40 „ of 4%
50 „ of 2%
4.8 gms.
3.0 „
6.0 „
..
..
..
..
..
..
..
..
..
..
..
..
..
..
Method
administered.
Subcutaneous ..
„ ..
„ ..
„ ..
„ ..
„ ..
„ ..
„ ..
„ ..
„ ..
Intravenous ..
„ ..
By mouth
„ ..
„
Periods.
9 days.
7 „
Cured 8½ months.
4 days.
6 „
7 „
6 „
7 „
3 „
5 „
8 „
6 „
5 „
No effect.
„
Died in 17 hours.