55.
TABLE
Showing the average daily Urea, Urine, and Water drunk, with the ratio of Urea to Urine, and Urine to Water in
periods of 7 days during health, disease, treatment, and after cure.
Periods of Health and
Disease.
Days Health.
6 days
Latent Period.
6
days ...
Paroxysm.
5
days
Intermission weeks.
Days.
60
4 3
Days,
106
5
2 }
{454grains
of Arsenic
administered.
{ 1822.75 c.c. of Iodides of Ar s eni c
and Mer r y administered.
1° ...
2° ...
3° ...
4° ...
5° ...
6° ...
7° ...
8° ...
9° ...
10° ...
11° ...
32° ...
13° ...
14
...
15° ...
16° ...
17° ...
1S° ...
19° ...
20° ...
21°
22° ...
23° ...
24° ...
25°
..
26° ...
27° ...
Average
daily
Urea.
Grammes.
21.42
19.71
52.90
33.61
30.89
36.43
29.99
20.98
21.86
23. 57
23.31
44.51
36.00
50.45
56.27
121.12
103.69
73.77
65.69
73.09
109.33
113.45
111.45
84.07
91.51
81.76
92.69
93.08
99.62
90.01
88.08
73.99
Average
daily Urea.
Litres.
255
1.364
1.892
1.070
1.443
1.801
1.797
1.418
1.630
1.692
1.336
1.842
1.573
2.7l
1.966
3.030
2.596
2.523
3.065
3.523
4.376
4.617
4.357
3.517
3.447
4.011
5.106
4.456
3.785
5.106
4.291
4.873
Average
daily W a ter
drunk.
Litres.
14.44
13.87
15.96
16.04
20.03
21.66
14.66
16.77
18.08
12.29
16.29
20.09
20.33
20.68
19.38
18.24
20.52
18.40
22.31
23.21
22.15
23.53
15.55
14.25
11.24
14.58
13.52
10.15
7.69
13.68
15.06
12.91
Ratio of
Urea to
Urine
1 : 58.50
1 : 69.22
1 : 35.80
1 : 31.80
1 : 46.40
1 : 49.40
1 : 59.92
1 : 67.60
1 : 74.60
1 : 71.78
1 : 57.30
1 : 41.36
1 : 43.70
1 : 43.04
1 : 34.93
1 : 25.01
1 : 25.04
1 : 34.20
1 : 46.70
1 : 48.20
1 ; 40.02
1 :40.69
1 : 39.10
1 :4l.80
1 : 37.70
1 : 49 .00
1 : 56.00
1 :45.60
1 : 56.72
1 : 48.72
1 : 48.75
1 : 65.90
Ratio of
Urine to
Water.
1 : 11.50
1 : 10.16
1 : 8.43
1 : 34.98
1 : 13.98
1 : 12.02
1
8.16
1 : 11.83
1 : 11.09
1 : 7.28
1 : 12.19
1 : 10.90
1 :. 12.92
1 : 9.52
1 : 9.85
1 : 6.02
1
7.90
1 : 7.29
1 : 7.28
1 : 6.59
1 : 6.06
1 : 5.09
4 : 3.57
1 : 4.05
1 : 3.26
1 : 3.63
1 : 2.37
1 : 2.28
1 : 2.03
1 : 2.68
1 : 3.51
1 : 2 64
Average
daily
Dung.
Kilo-
grammes.
...
...
...
...
...
...
...
...
...
...
...
...
...
...
Periods of Health and
Discase.
Intermission weeks.
Days.
226
period of non-
treatment
28° ...
29° ...
30° ...
31° ...
32° ...
33° ...
34° ...
35° ...
36°
..
37° ...
38° ...
39° ...
40° ...
41° ...
42°
43° ...
44° ...
45° ...
46° ...
47° ...
48° ...
49° ...
50° ...
51° ..
52° ...
53° ...
54° ...
55° ...
56° ...
During administration
of Arsenic...
During administration
of Iodides of Arsenin
and Mercury
During period with
out Treatment
During
the whole
period
Average
daily
Grammes.
91.04
81.09
88.82
50.94
68.90
84.90
84.28
103.93
84.52
146..46
96.53
81.59
82.97
75.93
79.54
92.37
89.41
101.56
107.52
117.18 112.46
90.90
102.79
123.72
115.89
102.84
102.02
119. 2
100.08
28.71
86.53
94.91
80.33
Average
daily
Urine.
Litres.
4.949
4.681
6.214
6.110
6.609
6.388
8.043
7.908
6.580
6.739
5.344
6.451
5.371
6.111
6.479
8.000
7.200
7.757
7.650
5.976
4.843
5.263
5.937
5.606
4.726
5.093
5.174
5.834
5.664
1.543
3.162
6.026
4.437
Average
daily
Water
drunk.
Litres.
5.46
13.59
13.84
6.59
11.08
15.39
13.35
16.37
17.26
15.39
19.29
20.76
24.35
20.52
22.31
22.67
24.18
27.19
20.34
21.90
23-84
27.18
92.45
19.38
22.47
26.95
21.90
24.43
22.07
17.18
18.06
18.78
38.19
Ratio of
Urea to
Urine.
1 : 54.36
1 : 57.30
1 : 69.96
1 : 107.30
1 : 95.90
1 : 75.24
1 : 95.43
1 : 76.08
1 : 77.85
1 : 45.92
1 : 55.36
1 : 79.07
1 : 70.77
1 : 80.49
1 : 81.45
1 : 86.60
1 : 80.53
1 : 76.38
1. : 71.15
1 : 50.99
1 : 43.06
1 : 58.41
1 : 57.76
1 : 46.31
1 : 40.77
1 : 49.53
1: 50.71
1 : 48.98
1 : 56.59
1 : 53.76
1 : 36.54
1 : 63.49
1 : 55.23
Ratio of
Urine to
Water.
1 : 1.10
1 : 2.90
1 : 2.23
1 : 1.08
1 : 1.68
1 : 2.41
1 : 1.66
1 : 2.07
1 : 2.62
1 : 2.28
1 : 3.61
1 : 3.22
1 : 4.15
1 : 3.36
1 : 3.44
1 : 2.83
1 : 3.36
1 : 3.50
1 : 2.66
1 : 3.66
1 : 4.92
1 : 5.16
1 : 3.78
1 : 3.43
1 : 4.75
1 ; 5.29
1 : 4.23
1 : 4.l8
1 : 3.89
1 : 11.13
1 : 5.71
1 : 3.12
51 : 4.09
Average
daily
Dung.
Kilo-
grammes.
...
...
...
15.45
18.47
21.37
19.77
17.40
39.18
16.20
18.24
19.35
21.65
20.64
22.31
25.36
23.32
22.69
24.63
23.18
22.84
24.83
22.24
20.61
21.98
23.91
24.18
22.74
23.03
21.36
Remarks:— This animal was subjected to treatment by Arsenic immediately on the appearance of Surra hæmatozoon.
The Surra organism appeared on 1st December 1893, and disappeared from the blood, on the 6th December, after which
date it did not recur, although careful microscopical examinations of the blood were continued daily for a total period
of 409 days. The Arsenical treatment was carried on for sixty days, when the Double Iodides of Arsenic and Mercury
were substituted and administered for a further period of 106 days. In all, 454 grains of Arsenic and 1,822.75 of the
solution of the Double Iodides were given. The latter corresponds to Arsenic 48.66 grains, Mercury 127.59 grains
and Iodine 401.00 grains, or 288 grains of each of Iodide of Arsenic and Iodide of Mercury.
It will be noticed on reference to Photograph No. I. page
that on the fiftieth (50th) day of the disease
the animal was in poor condition, and had lost a total of 273 lbs. which, however, it fully recovered, but not until seven
months after the commencement of the disease, when it weighed 1,070.1 lbs.
The physiological problems relating to the ingestion and egestion of Nitrogen, water, &c, will be fully discussed
in Vol. III with the results of numerous other experimental cases. A few remarks on the Nitrogen question, with
reference to this case, are here recorded.
(a) The small amount of urine and urea excreted during the period of health (i. e.) previous to inoculation,
viz.,—a daily average of 1.255 litres and 21.42 grammes respectively.
(i) A slight decrease of urea during the latent period, with a corresponding increase in the quantity of urine.
(c) A great increase of urea with only a slight increase of urine during the paroxysm.
(d) A small excretion of urea and urine during the sixty days of Arsenical treatment, averaging daily only 28.71
grammes urea, and 1.543 litres urine.
(e) The striking increase of both urea and urine during the administration of the Double Iodides, amounting to
86.53 grammes, and 3.162 litres respectively.
(f) And again a still greater increase, especially with regard to the urine, after the exhibition of the drugs had
ceased, a period of 226 days.
The ratio of excretion of urea and urine during the periods above noted in this case is as follows : —
Health ...
Latent Period
Paroxysm
Arsenical Treatment
Double Iodide do.
After Treatment
..,
Urea.
... 1.08
... 1.00
... 2.67
... 1.45
... 4.38
... 4.81
Urine.
1.00
1.08
1.50
1.23
2.52
4.80