NationalLibraryOfScotland/medical-history-of-british-india huggingface dataset:
67
Date.
1894.
April 24...
„
„
„
„
„
„
May
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
June
„
„
25...
26...
27...
28...
29...
30...
1...
2...
3...
4...
5..
6...
7...
S...
9...
10...
11...
12...
13...
14...
15...
16...
17...
18...
19...
20...
21...
22...
23...
44...
25...
26...
27..
28..
29...
30..
31...
1...
2..
3...
Temperature °C.
A.M.
37.7
37.6
37.5
37.7
37.3
37.2
37.5
37.6
37.4
37.6
37.7
37.4
37.8
37.6
37.6
37.8
37.7
38.1
38.6
38.3
38.0
38.1
37.4
37.5
37.7
37.6
37.5
37.6
37.7
37.7
38.2
38.1
39.5
41.0
37.4
37.6
39.3
37.8
37.4
37.8
37.5
1
P.M..
...
...
...
...
...
...
...
...
...
..
...
..
...
...
...
...
...
...
...
...
...
...
..
..
38.0
38.3
38 .3
40 .7
41.4
37.7
37.8
41.7
37.5
37.8
38.1
37.6
5 P.M.
37.6
37.8
37.7
37 7
37.7
37.6
37.7
37.8
37.6
37.8
37.8
37.7
37.6
37.7
37.8
37.8
38.2
39.0
39.2
39.0
38.4
38.2
38.0
37.8
38.0
37.7
37.6
37.S
38.1
37.7
38.2
38.4
41.0
41.2
37.6
38.0
41.1
37.4
38.0
37.8
38.2
Pulse.
A.M.
35
35
36
37
37
35
36
36
39
37
36
36
35
35
35
36
36
36
49
54
43
45
38
37
35
34
34
35
35
35
38
36
42
55
37
36
44
48
40
48
38
P.M.
33
34
37
36
38
36
35
38
35
36
38
39
40
32
37
41
40
37
44
60
42
40
36
35
33
34
28
37
44
34
37
39
61
56
41
38
63
44
41
41
35
Respiration.
A.M.
25
25
27
24
28
18
11
12
22
20
28
25
23
21
14
13
15
13
22
30
19
13
22
35
12
21
17
12
26
22
40
28
11
12
22
21
8
21
23
16
12
P.M.
31
24
24
31
31
24
23
24
19
32
22
28
28
22
28
27
29
42
36
28.
28
26
24
24
30
35
24
28
44
16
26
40
45
32
26
25
41
21
34
38
42
Day of
Disease.
...
...
...
...
...
...
Hæmatozoa
in the Blood.
....
....
....
........
....
........
......
...
...
...
...
...
...
...
...
...
...
..
...
...
......
...
...
...
...
...
...
......
......
...
l
2
3
4
5
6
7
8
9
....
....
.....
....
....
....
....
....
....
....
....
....
.........
....
....
....
....
....
....
....
Inoculated
Absent
„
„
„
Few
„
„
Absent
Few
„
„
Absent
„
REMARKS.
Both conjunctivæ clear.
Do.
Do.
Slight trace of petechiæ in the
right conjunctiva; left, clear.
Both conjunctiva clear.
Do.
do. Slight
swellings on both shoulders.
Do.
do.
Right conjunctiva one spot;
left, clear ; slight swellings on
shoulder.
Right conjunctiva one large
spot; left, clear. Slight swell
ings on shoulder.
Right conjunctiva trace of
petechiæ.
Left conjunctiva
yellowish, but free from pete
chiæ. Slight
swellings on
shoulder.
Both conjunctivæ clear. Swell
ings continue.
Do.
do.
Do.
do.
Do.
do.
Do.
do.
Do.
do.
Right conjunctiva slightly con
gested ; left, clear.
Both conjunctivæ clear.
Right conjunctiva slightly con
gested; left, clear.
Small
raised swellings on both shoul
ders and flanks.
Right conjunctiva extravasated ;
left, one spot, injected. Swell
ing at seat of inoculation 2¼" x
2" X ⅜". Tenderness
dis
appeared
Right conjunctiva one extrava
sation ; left, yellow and petechi-
ated. Swelling hard and flat.
Conjunctivæ yellow.
General
urticarial eruption; near hind
leg much swollen. Corn re
fused.
Right conjunctiva yellow and
injected; left, yellow and pete*
ciliated; eruption on both
shoulders; near hind leg much
swollen. Corn refused.
Conjunctivæ petechiated, erup
tion disappearing.
Conjunctivæ less petechiated
eruption re-appearing.
Right conjunctiva clear; left,
one extravasation.
72
Health
Preliminary Treatment ...
Latent Period
Paroxysms ...
Intermissions
Whole Period
Average daily
Urine.
c.c.
2,721
3,666
4,107
8,510
8,430
5,938
Average daily
Urea.
Grammes.
38.89
75.09
82.05
156.82
124.95
102.07
Average daily
Water drunk.
Litres.
30.78
15.70
14.53
9.59
8.94
13.12
Ratio of Urea to
Urine.
1 : 69.9
1 : 44.8
1 : 50.0
1 : 64.2
1 : 67.4
1 : 58.2
HORSE No. CIII.
Grey Entire, Country-Bred, brought from Wai, a village beneath the Panchgani Gháts, well known as a fever
locality and liable to inundation during the rains, and therefore probably a Surra centre also.
June 29th, 1894, State on Admission.—The animal is aged and in fairly good condition. The visible mucous mem-
branes are clear, the skin cool, and the temperature within normal limits, 38.2°C. Pulse 38, R. 28. The extremities
are coarse, but there is no swelling or œdema present. The appetite is good, and the excreta normal in character.
Month and Date.
1894.
June 29...
„ 30...
July 1...
„
2...
„ 3...
„ 4...
„
5...
„ 6...
„
7...
„
8...
„
9...
„ 10...
„ 11...
„ 12...
„ 13...
„ 14...
„ 15...
„ 16...
„ 17...
„ 18...
„ 19...
„ 20...
„ 21...
„ 22...
„ 23...
„ 24...
„ 25...
„ 26...
„ 27...
„ 28..
„ 29..
„ 30...
Temperature °C.
A.M.
38.2
37.4
37.3
37.1
37.2
36.7
37.4
36.6
36.7
37.0
36.6
36.4
36.4
36.1
36.1
36.1
36.8
36.5
36.3
37.2
36.4
35.7
35.8
36.5
37.3
36.7
37.7
39.0
39.6
40.1
39.6
38.0
1.P.M.
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
39.6
38.4
5.P.M.
38.2
37.5
38.1
38.0
38.0
38.3
38.2
38.1
38.0
37.7
37.3
37.2
37.2
36.8
36.8
37.7
37.4
37.1
37.5
37.7
37.0
36.4
37.0
38.0
37.7
37.4
38.3
40.0
40.1
40.2
40.2
39.6
Pulse.
...
52
32
32
24
24
30
32
22
26
24
28
20
24
24
20
32
24
24
24
20
20
24
52
26
24
24
28
32
48
31
30
39
34
30
26
28
30
30
44
34
32
32
32
40
24
26
40
20
48
48
44
40
48
52
28
28
24
28
28
28
32
34
34
Respiration.
...
16
20
12
12
16
14
16
11
12
12
12
12
12
12
12
12
10
12
12
12
8
12
12
12
8
12
10
12
12
12
12
28
16
14
12
10
14
16
20
11
12
12
12
12
12
12
12
12
16
9
12
10
12
12
12
12
12
8
12
12
12
11
12
Day of
Disease.
...
...
...
...
...
...
...
...
...
...
....
....
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
1
2
Condi-
tion of
Blood.
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
Heal-
thy.
....
Few.
„
Medicine administered.
A.M.
P.M.
Double Iodide of
Arsenic and Mer-
cury.
cc cc
...
viiss
x
x
x
x
xiiss
xiiss
xv
xv
xv
xviiss
xviiss
xviiss
xviiss
xviiss
xviiss
xviiss
xviiss
xx
xx
xx
xxiiss
xxiiss
xxv
xxv
xxvi
xxvi
xxvii
xxvii
xxvii
...
v
viiss
x
x
x
xv
xiiss
xiiss
xv
xv
xv
xviiss
xviiss
xviiss
xviiss
xviiss
xviiss
xviiss
xviiss
xx
xx
xx
xxiiss
xxiiss
xxv
xxv
xxvi
xxvi
xxvii
xxvii
...
...
REMARKS.
Conjunctival mem¬
branes much in-
jected and pete¬
chiated,
dis¬
chargefrorn right
nostril.
Conjunctival mem¬
branes much in¬
jected, yellow,
and petechiated.
Conjunctival mem¬
branes much in-
jected,
yellow
and petechiated,
lowerextremities
of all four limbs
swollen ; slight
general urtica¬
rial eruption.
B.
RAT SURRA
APPENDIX I.
SUBCUTANEOUS INOCULATION WITH
SOILED RAT'S BLOOD.
RESULTS POSITIVE.
HORSES Nos. IX, XXVIII, XLII, LXII.
B.
RAT SURRA.
APPENDIX II.
SUBCUTANEOUS INOCULATION WITH BLOOD
DERIVED FROM POSITIVE CASES.
RESULTS POSITIVE.
HORSES Nos. XXXV, XXXVI, XLV, LXVII, XXXVII.
B 2236- 22 ap
94
Thorax.—No fluid in the cavity of the pleuræ, and no adhesions.
Lungs.—The apices as well as the free borders of both lungs, are the seat of well marked localized emphysema.
Both organs are dotted over the surfaces with extravasations involving the tissues for a varying depth, 1/16th to ¼th of
an inch. On section, the upper and middle lobes present a peculiar reddish-yellow colour, but the tissues are fully
distended with air. The lower lobes are dark or variegated in colour on their cut surfaces, and present a dark-red
colour, which resembles an early pneumonic condition.
Little or no fluid in the pericardial cavity.
Heart.—The large vessels situated at the base of the organ are covered with a layer of sherry-coloured exudation
varying from ¼" to 1" in depth, which is especially extensive and deep over the pulmonary artery. The external surfac
of the heart is almost covered with extravasations of blood, some very extensive, especially round the base and along
the course of the coronary vessels. Extravasations of blood also involve the exudation-material.
Internally.—The right auricle contains semi-fluid dark-coloured blood, and a few small sub-endocardial ext rava¬
sations. The right ventricle also contains dark clots, few and small, but the endocardial lining, for the most part,
presents a totally black colour, especially over the inter-ventricular wall, due to extraordinarily extensive sub-endocar¬
dial extravasations, which are found to involve the muscular wall to some depth. The tricuspid and pulmonary val ves
are healthy, except for a peculiar yellow tinge which is common to the membranes of the whole body. The left auricle
and ventricle present a few extravasations, small in size, and only superficial compared with those found in the right
ventricle. Valves healthy.
Liver.—Weighs 7 lbs. 8 ozs. and appears to be very small. The convex surface presents old signs of perihepatitis
and is of a dirty brown colour.
Spleen.—Weighs 1 lb. 6 ozs. Numerous and extensive extravasations are present on both surfaces of the organ.
On section, the tissues are firm and appear healthy.
Stomach.—Small, contracted. On section, the cuticular portion is healthy. The mucous membrane of the
portion is corrugated and of a more or less red colour, with small dark-red patches, situated on the summits of the
rugæ. There are numerous small nematodes " Spiroptera megastoma " singly and in skeins, dotted over the surface o
villous portion between the rugæ.
Kidneys.—Right
weighs 1 lb. 1½ ozs., Left 15½ ozs. Both organs are found lying in a layer of exudation ½
thickness. The organs are small, dark in colour, and the stellate veins injected. The capsules do not strip easily. On
section, the cortical zone in each organ appears somewhat narrower than normal; the tissues are congested.
Intestines.—Normal in appearance.
Brain.—The membranes are somewhat pale in colour. The superficial veins are not fully distended ; the brain
substance is pale, and there is about three drachms of clear fluid in each lateral ventricle. There are no extravasations
on the surface, or on section of the organ.
B.
RAT
SURRA
APPENDIX III.
SUBCUTANEOUS INOCULATION WITH
SOILED RAT'S BLOOD.
RESULTS NEGATIVE.
HORSES Nos. LVII, LII, XLIV.
98
Remarks.—This horse was inoculated subcutaneously with the blood of the rat, containing numerous hæmatozoa
January 14th, 1892, and as all swelling had absolutely disappeared from the seat of inoculation for a period of 26 days,
and the symptoms of mal-assimilation of food still continued, the animal was destroyed with the aid of chloroform,
no hæmatozoa at any time since the date of inoculation having been observed in the blood.
HORSE No. LII.
Black country-bred pony, aged, in good condition.
Date.
1891.
October 23
...
„ 24 .....
„ 25 ...
„ 26 ....
„
27
...
„ 28
...
„
29 ...
„
30 ...
„ 31 ...
November 1 ..
„
2
„ 3 ...
„ 4
....
„ 5 ...
„
6
...
„
7
...
„ 8 ...
„ 9 ...
„ 10 ...
„ 11 ...
„ 12 ...
„ 13 ...
„
14 ...
„ 15 ...
„ 16 ...
„ 17 ...
„ 18 ...
Day of
Disease.
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
Temperature °C.
A.M.
36.5
36.7
36.1
36.8
37.3
36.7
37.2
37.3
37.4
36.7
37.1
36.7
36.7
37.2
37.6
37.2
38.1
39.5
38.5
36.8
37.8
36.7
36.0
37.0
37.0
37.3
37.4
1 P.M.
...
...
...
...
...
...
...
...
38.4
38.1
38.1
38.1
37.5
37.8
38.2
38.2
39.0
39.8
39.0
38.5
39.3
37.6
38.1
38.0
37.7
38.8
39.3
5 P.M.
38.1
37.4
37.7
37.6
38.2
38.1
37.8
38.1
38.3
38.3
37.3
38.3
38.2
38.3
37.7
38.3
39.0
39.6
38.7
38.3
38.4
37.5
38.5
38 3
38.0
38.2
39.0
Hæatozoa
in Blood.
Healthy ...
„
...
„
...
„ ...
„ ...
„ ...
Nematodes...
Absent
Hæmatozoa
absent.
„ ...
„ ...
„ ...
„ ...
Nematodes ...
Absent
„ ...
„ ...
Nematodes ...
Absent ...
Nematodes ...
Absent ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
REMARKS.
29th.—Nematodes in the blood.
30th.—Blood free from nematodes. 5-15 P.M.
The animal was inoculated subcutaneously over
the right and left scapular regions, with 2. 0 c.c.
of blood containing numerous hæmatozoa, drawn
from the hearts of two rats (Mus decumanus),
mixed with .6 per cent. salt solution (immedi¬
ately after death).
31st.—At the seat of inoculation on either side,
there is a raised swelling, apparently from
manipulation full of a jelly-like material.
1st.—The swelling on the right side continues
unchanged ; on the left, decreased.
8th.—There is a slight muco-purulent discharge
from both nostrils. Considerable swelling and
œdema at the seat of inoculation over the left
scapular.
9th.—Discharge from nostrils ceased. A second
swelling has appeared, posterior to the one
over the left scapular region. No. 1 measures
5.5" × 3.5" × 1" and No. 2,4" ×2.75" × 1".
Both are very tender on manipulation.
10th.—The swellings are somewhat increased in
size, and have become hard and tense, and are
exceedingly tender on manipulation.
11th.—The swelling has slightly decreased at
the seat, of inoculation, and the tenderness is
not so marked ; conjunctival membranes clear.
12th.—Swelling still further reduced in size.
No petechiæ on the conjunctivæ.
13th.—Condition unchanged.
14th.—The swelling and œdema at the points of
inoculation have entirely subsided, but there
is a small hard body to be felt in the centre of
the patch occupied by the swelling on the 9th
instant.
15th.—Condition unchanged.
16th.—
Do.
17th.—
Do.
18th.—
Do.
99
Date.
1891.
November 19 ...
„
20 ...
„
21 ...
„
22 ...
„
23 ...
„
24 ...
„
25 ...
„
26 ...
„
27 ...
„
28 ...
„
29 ...
„
30 ..
Day of
Disease.
....
...
...
...
...
...
...
...
...
...
...
Temperature °C.
A.M.
37.2
36.7
38.4
37.5
36.6
36.2
37.3
36.8
36.8
37.5
37.0
37.6
1 P.M.
38.7
39.0
40.1
39.5
38.3
38.3
38.1
38.5
38.0
38.2
38.4
38.2
5 P.M.
38.6
38.7
39.7
39.2
37.7
37.6
38.0
38.0
38.2
38.3
38.4
38.2
Hæmatozoa
in Blood.
Absent ...
„
...
„ ...
„
...
„ ...
„ ...
„
...
„ ...
„ ...
„
...
„ ...
„ ...
REMARKS.
19th.—Inoculated subcutaneously over the right
scapular region with 2.0 c.c. of blood containing
hæmatozoa, mixed with .6 per cent. salt solution,
taken from the hearts of several small rats
(Mus decumanus) immediately after death.
20th.—There is a raised swelling at the seat of
inoculation 4"×2.5"×1"; conjunctival mem¬
branes tinged yellow, but there are no petechiæ.
21st.—Condition unchanged.
22nd.—
Do.
23rd.—
Do.
24th.—The swelling has somewhat increased in
size, and is tender on manipulation.
28th.—The swelling is somewhat reduced in size,
and the tenderness is less marked.
30th.—Swelling still further reduced in size.
This animal's temperature was carefully taken, three times, and the blood examined once daily for a further period
of fifty-nine days, but no hæmatozoa were observed in the blood ; the temperature remaining normal or subnormal. On
January 28th, 1892, the animal developed Lymphangitis of one extremity, and was immediately destroyed with the aid
of chloroform.
Remarks—
The points of interest in this case are—
1st.—The presence of small nematodes in the blood previous to inoculation.
2nd.—That the primary inoculation with rat's blood conducted on the 30th October, should have been followed
by considerable swelling and œdema at and around the seats of inoculation, but should have produced
so little general disturbance of the system.
3rd.—That three weeks later re-inoculation with blood from a similar source, and at the seat of the former
injection, should have produced like changes to those observed after the primary inoculation.
4th.—That the changes observed after re-inoculation were quite as extensive and virulent in character as
those which occurred after the primary one.
HORSE No. XLIV.
Dunn country-bred, aged, but in good condition.
Date.
1891.
September 21
„ 22
„
23
„ 24
„ 25
„ 26
„ 27
„
28
„ 29
„ 30
October
1
„ 2
„
3
„ 4
Temperature °c.
A.M.
...
35.8
36.2
36.1
36.4
36.0
35.6
36.7
35.7
35.6
35.7
35.6
35.7
36.2
1 P.M.
...
...
...
...
...
...
...
...
...
...
...
...
37.3
37.4
5 P.M.
37.0
37.1
37.2
37.3
37.1
37.2
37.3
37.5
37.3
37.6
37.4
37.3
37.5
37.4
Hæmatozoa
in Blood.
Healthy.
„
„
„
„
„
„
„
„
„
„
„
Absent.
„
REMARKS.
Inoculated subcutaneously over the right scapular region with 1.0 c.c.
of blood containing swarms of hæmatozoa, taken from the hearts of
rats (Mus decumanus) immediately after death.
There is no swelling or œdema at the seat of inoculation.
„ „ „
B.
RAT
SURRA
APPENDIX IV.
SUBCUTANEOUS INOCULATION AND RE-INOCULATION AT A LATER PERIOD WITH
SOILED RAT'S BLOOD WITH NEGATIVE RESULTS ; FURTHER INOCULATION OF
THE SAME ANIMAL WITH SOILED HORSE SURRA BLOOD. RESULTS POSITIVE
(A) DIRECTLY INTO THE JUGULAR VEIN-
HORSE No. XIII.
(B) SUBCUTANEOUSLY—
HORSES Nos. XII, XLVIII, XLVI, LVIII.
B 2236- 26 ap
108
Date.
1891.
October
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26 ...
27...
28...
29...
30...
31...
November 1...
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2 ...
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December 1 ...
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3 ...
Day of
Disease.
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Temperature °C.
A.M.
36.7
37.1
36.7
36.8
36.7
36.8
36.6
36.4
36.4
36.0
36.1
36.6
37.0
37.8
37.6
37.6
37.1
35.8
36.3
35.5
36.5
36.1
36.5
35.6
35.5
35.5
36.6
35.5
36.1
35.6
36.2
36.1
36.3
36.7
36.6
37.0
38.1
40.1
36.8
1 P.M.
38.0
38.1
38.1
38.2
38.1
38.1
38.1
37.5
37.7
37.8
38.1
38.1
38.3
38.4
38.4
38.0
38.5
37.7
37.2
37.5
37.3
37.3
38.0
37.0
37.6
37.2
37.5
37.7
37.5
37.6
38.0
38.0
37.6
38.1
37.6
38.0
39.4
39.8
37.8
5 P.M.
38.0
38.1
38.0
38.3
37.6
38.1
38.1
37.8
38.3
38.1
38.4
38.4
38.2
38.3
38.5
38.3
38.6
38.3
37.8
38.0
37.8
38.1
38.0
38.0
37.5
37.8
37.7
37.5
36.7
37.5
38.3
37.8
37.6
38.1
38.0
38.6
39.0
38.6
39.6
Hæma-
tozoa in
Blood.
Absent
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Few.
Nume-
rous.
Very
nume-
rous.
Urine.
Colour.
Turbid.
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Sp. Gr.
1,028
1,038
1,032
1,028
1,028
1,022
1,024
1,029
1,028
1,048
1,012
1,032
1,048
1,046
1,040
1,035
1,033
1,040
1,037
1,055
1,028
1,031
1,038
1,032
1,029
1,027
1,022
1,024
1,032
1,035
1,039
1,040
1,044
1,038
1,041
1,037
1,040
1,038
1,042
Reaction
Alka-
line.
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Albu-
men.
Nil.
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Phos-
phates.
Trace.
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REMARKS.
26th.—Swelling smaller.
30th.— Swelling almost en-
tirely disappeared.
31st.—
Do.
do.
1st.—Swelling entirely dis-
appeared.
23rd.—As the animal con-
tinues in good health, it
was decided to inoculate
with Horse-Surra blood ;
consequently at 9-30 A.M.,
it was inoculated subcu-
taneously with 1 c.c. of
blood, taken from the heart
of Horse XLVIII, 8½ hours
after death.
27th.—There is a small cir-
cular raised swelling at the
seat of inoculation.
28th.—Swelling now mea-
sures 1.5" in diameter, and
is tender on manipulation.
29th.—Swelling 2" in dia-
meter and raised 1" above
surrounding tissues ; it is
tense and extremely tender
to the touch.
30th.—Swelling further in-
creased.
1st.—Swelling
somewhat
smaller and tension re-
duced.
2nd.—Animal shows marked
signs of weakness and is
extremely dull. The visi-
ble mucous membranes are
tinged yellow, and there
are some petechiæ on both
conjunctivæ.
3rd.—Animal weaker ; some
œdema of hind limbs below
the hocks. Swelling at
seat of inoculation further
reduced in size, and tender-
ness disappeared.
111
Date.
1892
April
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May
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4...
5...
6...
7...
8...
9...
10...
11...
12...
13...
14...
15...
16...
17...
18...
19...
20...
21...
22...
23...
24...
25...
26...
27...
28...
29...
30...
1...
2...
3...
Day of
Disease.
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1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
Temperature °C.
A.M.
39.8
38.1
38.1
39.5
40.6
39.7
39.5
40.6
39.2
38.1
38.7
38.1
41.3
42.1
38.1
38.1
38.5
39.1
40.6
40.5
40.2
39.8
39.4
40.0
40.7
40.5
40.0
40.0
38.8
39.8
1 P.M.
40.1
40.0
39.0
40.0
41.5
40.2
40.0
41.3
39.4
39.3
39.2
39.0
41.4
41.4
38.6
39.1
38.4
39.8
41.2
41.0
40.3
40.4
40.1
40.7
41.1
40.7
40.6
40.2
39.7
40.5
5 P.M.
39.6
39.5
39.3
40.3
41.5
40.4
40.5
40.4
39.3
39.5
39.6
39.4
41.2
40.5
39.1
39.0
39.3
40.0
41.7
40.6
40.3
40.4
40.1
40.7
41.3
40.7
40.6
40.1
40.1
42.0
Pulse.
A.M.
68
48
48
48
60
72
60
72
72
72
72
52
72
70
60
56
60
60
78
80
72
66
58
53
60
60
64
64
60
60
P.M.
52
48
48
56
64
72
70
76
75
72
67
60
75
65
60
56
56
65
78
78
70
60
55
56
60
64
64
64
60
136
Respira-
tion.
A.M.
36
27
36
32
38
38
42
60
40
40
40
42
54
56
60
42
42
42
56
56
51
60
60
39
33
47
40
39
36
40
P.M.
30
33
32
36
40
38
52
56
40
40
40
45
56
56
54
40 42
44
49
52
55
60
54
37
40
40
39
39
36
56
Hæmatnzoa
in Blood.
Absent ...
„ ...
„ ...
Numerous ...
Very
numerous.
Very
numerous.
„ ...
Numerous ..
Absent
„ ...
„ ...
Few
Swarming ...
Absent ...
„ ...
Few
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...
Very
numerous.
„ ...
Numerous ...
Few ...
Absent ...
„ ...
Very
numerous.
Numerous ...
Few ...
Absent ...
„ ...
Few
REMARKS.
4th.—The lower swelling- has disap-
peared, but the central one is in-
creased, measuring 5" × 3".
5th.—
Do.
do.
6th.— The tumour at the seat of in-
oculation burst, and several ounces
of pus exuded.
7th.—Swelling considerably reduced
in size, and much of the tenderness
has disappeared. Pulse weak and
easily compressible.
8th, 8 A.M..—Urticarial eruption in-
volving head and neck was first
observed. Hind limbs and sheath
swollen and œdematons. One large
extravasation, .25" square, present
on the left membrana nictitans.
11 A.M.— Eruption now covers the
fore limbs, chest and back, and by
noon the inguinal regions and inner
aspects of the thighs were involved.
6 P.M.—Ernption disappearing slow-
ly, and at 8 P.M. little remained.
9th. — Eruption entirely disappeared.
Conjunctival extravasation fading.
Pulse weak and irregular.
10th.—Few petechiæ on right con-
junctiva.
11th.—Animal dull, appetite poor.
Swelling and œdema of limbs, abdo-
men and sheath had increased.
4 P.M.—Breathing became embar-
rassed, and the visible mucous mem-
branes assumed a dirty yellow
colour.
12th —Swelling of abdomen de-
creased.
13th.—Animal brighter, appetite im-
proved, breathing frequent, but not
so embarrassed. Swelling at seat
of inoculation almost disappeared.
15th.—Swelling and œdema is spread-
ing along the under-surface of the
abdomen.
19th. — Swelling and œdema reduced.
22nd.—Animal weak, breathing more
frequent, appetice bad.
25th.—Animal weaker.
27th.—Animal still weak, but appetite
is good.
30th.—Animal weaker, but appetite
still continues good.
3rd.—Animal dying. Swelling and
œdema of abdomen has increased.
Chloroform administered at 6.45
P.M.