110
Date.
1892.
February 19...
„
20...
„
21...
„ 22...
„ 23...
„ 24...
„ 25...
„
26...
„
27...
,.
28...
„ 29...
March
1...
„ 2...
„ 3...
„
4...
„ 5...
„ 6...
„
7...
„ 8...
„
9...
„
29...
„
30...
„
31..
April 1...
„ 2...
„ 3...
Day of
Disease.
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
Temperature °C.
A.M.
36.2
37.5
37.6
37.0
37.4
37.5
37.4
36.5
36.2
38.0
36.5
36.7
36.4
37.0
36.3
36.1
36.3
37.0
36.3
37.3
37.8
38.3
38.5
38.1
38.1
39.0
1
P.M.
37.6
38.3
38.5
38.2
38.2
38.2
38.8
38.5
39.5
39.4
38.5
39.3
38.3
37.7
37.6
38.5
38.1
38.2
37.7
38.3
38.5
40.0
39.2
39.3
39.3
39.7
5
P.M.
37.5
38.5
38.2
38.2
38.0
38.5
37.7
37.7
39.8
39.2
37.8
39.5
38.1
38.2
38.3
38.1
38.2
38.2
38.5
38.5
38.1
39.5
39.1
39.1
39.0
40.4
Pulse.
A.M.
28
37
34
39
40
30
37
36
36
36
36
70
35
32
32
36
36
28
28
36
40
48
36
36
36
36
P. M.
30
40
40
42
41
33
35
38
47
40
32
65
35
34
33
36
33
28
32
36
44
48
38
36
36
54
Respira-
tion.
A.M.
20
20
20
18
18
13
12
24
14
15
18
20
16
11
11
12
12
16
16
22
24
36
28
28
24
20
P.M.
23
23
23
20
22
16
14
24
16
15
15
18
14
13
11
12
14
16
18
22
28
34
29
26
22
32
Hæmatozoa
in Blood
Absent
„ ...
„
...
„ ...
„ ...
.. ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
„ ...
REMARKS.
19th.—There is slight swelling at the
seat of inoculation.
20th.—Swelling increased, and some
tenderness.
21st.—Swelling now measures 2.5"in
diameter, with a zone of œdema
surrounding it.
22nd.—Swelling further increased,
considerable tenderness on press-
ure. Few small petechiæ on the
coniunctivæ.
23rd.— Do.
do.
24 th.—
Do.
do.
25th.— Do. do.
26th.—The œdemafcous zone has de-
creased in extent, and the animal
is bright.
27th.—Swelling decreased, but still
somewhat tender.
28th.—The rise in temperature was
due to the bite of a hornet on the
margin of the nostril.
1st.—Swelling at seat of inoculation
is now 2" in diameter. Somewhat
hard to the touch.
3rd.—Swelling further decreased, and
feels softer.
4th.—Swelling now measures only ¾"
in diameter.
7th.—The animal appears in perfect-
health.
9th.—Swelling entirely disappeared,
only slight thickening of tissues left.
From the 10th to the 28th March the
animal was apparently in good
health, with the exception of a rise
in temperature on the 25th instant.
29th.—As the animal has remained in
good health for 40 days since the
inoculation with rat's' blood, it was
decided to inoculate it with Horse-
Surra blood to see if any immunity
had been conferred by the first in-
jection. Consequently the animal
was inoculated at 10 A.M. with 1.0
c.c. of blood drawn from the
heart of Horse XLVII, 5 hours
after death. (Previous to death,
the injected blood
contained
swarms of hæmatozoa).
30th.—Slight swelling and tenderness
on pressure at the seat of inocula-
tion.
31st.—Increased swelling and ten-
derness.
1st.
Do.
do.
2nd.—Swelling and tenderness fur-
ther increased.
3rd.—There is an extensive, some-
what circular, raised swelling, 7'' in
diameter, and raised .75" above the
surrounding tissues at the seat of
inoculation ; occupying the centre
of the former is a second tumour
3.5"in diameter,and raised .7''above
it. These swellings are hard and
very tender on pressure.