126
Date.
1891—
March 5 ...
„ 6 ...
„ 7 ...
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8...
„ 9 ...
„ 10 ...
„ 11 ...
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12 ...
„ 13 ...
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15 ...
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16 ...
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17 ...
„ 18 ...
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25 ...
„ 26 ...
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27 ...
„ 28 ...
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29 ...
„ 30 ...
„ 31 ...
Apr. 1 ...
„
2 ...
Condition of Blood.
No. I.
Hæmatozoa very nu-
merous.
„ „ ...
„
numerous.
„ „ ...
„ „ ...
„ „ ....
„
few
„ „ ...
„ „
„
absent ...
„ „ ...
„ „ ...
„
few
„ „ ...
„ „
„
numerous.
„ „
„ „ „
„ „
„ „
„ „
„ „
„ „
„ „ ...
„ „
„ „
„ „ ...
„ „
„
absent ...
From this date until
the animal died, 26th
May 1891, the or-
ganism did not re-
appear in the blood.
Autopsy
immediately
after death.—There
are no hæmatozoa
upon
microscopical
examination of the
heart's blood.
All the organs, with
the exception of the
spleen, present a per-
fectly healthy appear-
ance. The spleen is
large, and of a dark
red colour. On sec-
tion, the tissues are
firm, and present no
pathological changes
to the naked eye.
Condition of Blood.
No. II.
Hæmatozoa numerous .
„ „
„
few.
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„
absent.
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„ „
From this date until
the animal died, 31st
July 1891, the orga-
nism did not re-ap-
pear in the blood.
Autopsy
immediately
after death.
The pathological lesion
found as at the autop-
sy of No. 1 is confined
to the spleen, the
other organs pre-
senting a healthy ap-
pearance.
Remarks.—The blood of Rats I and II was submitted to
careful microscopical examination for a period of three
days, and as during that time the blood appeared healthy
and no hæmatozoa were observed, the animals were inocu-
lated with 0.6 and 0.4c.c. of blood respectively, containing
numerous organisms, taken from the heart of a rat (Mus
decumanus.) immediately after death. The hæmatozoon
made its first appearance in the blood of each animal on
the morning of the eighth day after inoculation, numerous
in No. I and few in No. II.
The chief point of interest in these cases is that for 42
and 118 days, respectively, previous to death, the hæma¬
tozoon was absent from the blood.
Date.
1894—
July 12 ...
„ 13 ...
„ 14 ...
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15 ....
„ 16 ...
„ 17 ...
„ 18 ...
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„ 20 ...
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21 ...
„ 22 ...
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23 ...
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24 ...
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25 ...
„ 26 ...
„ 27 ...
„ 28 ...
„
29 ...
„ 30 ...
„ 31 ...
Aug. 1 ...
„
2 ...
„
3 ...
„ 4 ...
„ 5 ...
„ 6 ...
„
7 ...
„ 8 ...
„
9 ...
„ 10 ...
., 11 ...
„ 12 ...
„ 13 ...
„ 14 ..
„ 15 ...
„ 16 ..
„
17 ...
„
18...
„
19 ..
„ 20 ..
„
21 ..
Condition of Blood,
No. III.
Hæmatozoa absent ...
„ „ ...
„ „ ...
„ „ ...
„ „
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ....
„ „ ...
„ „ ...
„ „ ...
„ few
...
„
numerous.
„
absent ...
„ „
„ „
„ „ ...
„ „ ...
„
few
...
„
very nu-
merous.
„
numerous.
„ „ ...
„
few
„
absent ...
„ „ ...
„ „ ...
„ „ ...
„
few
„ „ ...
„ „
„ „
„ „ ...
„
very nu-
merous.
„
few
„
very nu-
merous.
„
few
„
numerous.
Death during
the
night.
Autopsy immediately after death.
The body is fairly well nourished,
and weighed 67 grammes, all
the organs with the exception of
the spleen present a perfectly
healthy appearance. The spleen
is small in size, weighs 0.47
grammes. Ratio of spleen to
body weight 1 : 142.5.
Condition of Blood.
No. IV.
Hæmatozoa few.
„
absent.
„ „
„ „
„ „
„
„
„ „
„ „
„ „
„
few.
„ „
„
absent.
„ „
„
few.
„ „
„ „
„ „
„ „
„ „
„ „
„ „
„
numerous.
„
very nu-
merous.
„
swarming.
„ „
„ „
Death at noon, 6th Au-
gust 1894.
Autopsy one hour after
death. Body fair-
ly well nourished,
weight 71 grammes.
Thorax.—The pleural
cavities are free from
fluid. The lungs are
pale pink in colour
and well distended
with air.
Heart externally and
internally presents a
healthy appeararice.
Peritoneal cavity is free
from fluid, but there
are several small ne-
matode worms lying
in it.
Stomach is small, and
on section is found to
contain one nema-
tode worm, but little
or no food. Spleen
appears slightly in-
creased in size, and
weighs 0.7 grammes.
Kidneys and bladder
healthy. Ratio of
spleen to body weight
1 : 101.4.
Remarks.—The blood of Rats III and IV was likewise
submitted to microscopical examination for several days,
and as during that time the blood presented a perfectly
healthy appearance, the animals were inoculated respec-
tively with 0.4 and 0.5 c.c. of blood containing swarms of
hæmatozoa obtained from the heart of a large rat (Mus
decumanus) immediately after death. In the case of No. III
the period of incubation occupied 39 days, while in that of
No. IV it was 24 days, but in this latter animal only one
hæmatozoon was observed in two specimens of blood ex-
amined and no further organisms were found for a further
period of nine days. In the case of both animals ; the or-
ganisms attained their maximum shortly before death,
which occurred in 65 and 49 days, respectively.