91
54 days less than in the case of the direct inoculation of rat's blood. Hæmatozoa present in blood-stained discharge
from the eyes. Death on the 2nd day of the disease. Marked pathological lesions of the organs.
Grey country-bred horse, aged, healthy and in fair condition.
Date.
1892.
July 18 ...
„ 19 ...
„ 20 ...
„ 21 ...
Day of
Disease.
...
...
...
...
Temperature °C.
A.M.
36.7
35.3
36.4
36 4
1 P.M.
36.8
37.0
37.3
37.6
5 P.M.
36.7
37.4
37.6
37.6
Pulse.
A.M.
72
32
32
25
P.M.
36
38
40
36
Respiration.
A.M.
16
16
14
11
P.M.
17
18
24
18
Hæmatozoa
in Blood.
Healthy.
„
„
„
Urine.
Colour.
Turbid.
„
„
„
Sp. Gr.
1,028
1,036
1,032
1,040
Reaction.
Alkaline.
„
„
„
Albn.
Nil
„
„
„
Hip.
Acid.
Nil
„
„
„
Phos.
Nil
„
„
„
2lst.—The animal was inoculated subcutaneously on the right shoulder with 1.0 c.c. of blood containing a few
„ 22 ...
hæmatozoa, taken from the jugular vein of Horse LXII.
...
36.4
37.4
37.4 36 38 12 16
Absent.
Turbid. 1,026
„
„
„
„
22nd.—Slight swelling .5" in diameter at seat of inoculation.
„ 23 ... ...
37.4
37.6
37.6 28 32 16 20
Absent. Turbid. 1,018 Strongly
alkaline.
„
„
„
23rd.—Swelling slightly increased.
24 ... ...
36.9
38.0
38.0 30 27 13 10
Absent.
Clear. 1,012
Alkaline. „
„
„
24th.—Swelling now measures l.25"in diameter and is raised in the centre. It is soft and only involves the skin.
„ 25 ...
25 th.—
„ 26
...
There are numerous dark claret-coloured petechiæ involving the membranæ nictitantes.
...
36.0
37.4
37.4 30 32 12 16
Absent.
Turbid. 1,017
„
.,
„
„
Do.
do.
do.
1 ...
38.0
37.4
39.0 36 36 20 20
Absent.
Turbid. 1,040
„
„
„
„
26th.—The animal is weaker, and the swelling has increased in size and is tense and tender on manipulation.
„ 27 ... ...
37.4
38.6
39.0 48 60 14
16
Absent.
Turbid. 1,040
„
„
„
„
27th.—Tension and tenderness increased.
„ 28 ... ...
38.6
39.3
39.3 43 48 21 16
Absent.
Turbid. 1,036
„
„
„
„
28th.—Swelling at seat of inoculation has increased and is now 2.5" in diameter; its convex surface presents
„ 29
...
29th.—
„ 30 ...
several nodules hard to the touch. The œdema has spread for several inches below the original swelling.
...
39.1 39.3
39.3 48 52 18 20
Absent.
Turbid. 1,040
„
„
„
„
Do.
do.
do.
1
39.3 39.6
39.7 48 56 12 24
Few.
Turbid. 1,038
„
„
„
„
30th.—The animal appears in the same condition, appetite good. The swelling and œdema have, as expected,
„ 31 ...
suddenly diminished in size and the hæmatozoa are present in the blood.
2
40.0
40.0
39.3 60 64 15 20
Very
numerous.
Clear. 1,040
Strongly
acid.
„
„
„
31st, A.M.—The animal is weaker, but stands without assistance. The swelling and œdema below the seat of
inoculation are disappearing, and the tumour itself is now only half the size, and soft to the touch. There is
œlema of the fore limbs. The appetite continued unimpaired. 6 P.M.—The sheath is swollen. Later, the
animal became weaker and at 11 P.M. was unable to stand.
1st August.—3 A.M.—Death.
Autopsy, six hours after death.
Body emaciated. Limbs and sheath swollen and œdematous.
Thorax.—The pleural cavities are free from fluid, and there are no pleuritic adhesions. Lying beneath the parietal
pleuræ, there are numerous patches of blood, only observable on the inner surface of the ribs, and not over the inter-
costal muscles.
Trachea.—The trachea internally presents a few extravasations, and these are entirely confined to the surface of
the mucous membrane lying on the cartilaginous rings, and not on the tissue lining the interspaces. There is a certain
amount of frothy mucus exuding from the bronchi and running into the trachea.
Right Lung.—The apex and inferior border are the seat of well marked emphysema. Dotted over the surface of
the whole organ are extravasations about the size of a two-anna piece, dark-purple in the centre, and presenting a lighter
hue externally. On section, the lung-tissue is of a dark-red colour, whilst a yellow serous fluid, mixed with air, flows
from the cut surfaces. On pressure, a considerable quantity of the same kind of fluid escapes. There is a patch, about
2" in diameter, at the base of the posterior lobe, which appears to be semi-solid ; but it is found to float in water. A
semi-gelatinous material exudes from the smaller bronchi, when cut across, and all the vessels contain black clotted
blood.
Left Lung.—The anterior portion, with the exception of the apex for a distance of two inches, together with the
inferior border, are the seat of well marked emphysema. The extreme apex, and for two inches posteriorly, the tissue
is of a dark-red colour and consolidated. Scattered over the surface of the lung, the same extravasations as seen on
the right organ are noticeable ; they lie just under the visceral pleura, and do not appear to invade the lung-tissue.
These extravasations are particularly well marked on the inferior surface of the organ, and are more extensive than
those on the superior surface. On section, a deeply blood-stained fluid, containing a considerable amount of air, escapes
from the cut surfaces ; and on pressure, the fluid loses its red and presents a yellow colour.
The pericardium contains about six ounces of a deeply blood-stained fluid. The internal surface of the membrane
is dotted over, especially round the portion covering the base of the organ, with several circular dark-coloured ecchy-
moses.