J.
CARMICHAEL
185
horses other than grey. Apart from possible
'racial' causes, hinted at by Virchow as 'con-
genital dyscrasia' and by M'Fadyean [1933] as
'predisposition by mutation', there exists another
suggestion: Post [1894] incriminated injurious
substances produced locally by melanotic cells
for provoking a neoplastic response on the part
of these cells. Eppinger [1910] regards 'the
excess of pigment and its products, especially
indol and skatol, as the cause of overgrowth of
the cells'.
SUMMARY
1. An account is given of specimens of melano-
mata of domesticated animals accumulated in
this Institute. Their general histological structure
is indicated and, where available, the clinical
records and autopsy findings have been added.
2. No attempt is made to elucidate the problem
of histogenesis of these tumours but only a general
review of the available literature is given.
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Aeby, C. (1885). Cit. M'Fadyean (1933)
Arey, L. B. (1932). In Cowdry's Special Pathology (1932).
3, 1273. Paul Hoeber, New York
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Beattie, J. M. and Dickson, W. E. C. (1926). Text-book of
Pathology, 308. W. Heinemann, London
Bloch, B.: Cit. Ewing. (1932)
Brown, W.H. and Pearce, L. (1926). J. exp. Med. 43, 807
Caylor, H.D. and Schlotthauer, C. F. (1926). Arch. Path.
2, 343
Cowdry, E. V. (1932). Special Cytology, 1, 11. Paul
Hoeber, New York
—
(1934). Text-Book of Histology, 449
Henry Kimpton, London
Dawson, J. W. (1925). Cit. Feldman, and Ewing
Demieville (1880). Cit. Ewing
Dorssen, J. van (1903). Cit. M'Fadyean (1933)
Ehrmann, S. (1885). Cit. M'Fadyean (1933)
Eppinger (1910). Cit. Goldberg, and Ewing
Ewing, J. (1934). Neoplastic Diseases, 919. W. B
Saunders Co., Philadelphia
Feldman, W. H. (1932). Neoplasms of Domesticated
Animals, 247. W. B. Saunders Co., Philadelphia
Frank, E. R. and Morrill, C. C. (1937). N. Amer. Vet., 18,
November, 23
Gessard, C. (1902). Cit. Goldberg, and Ewing
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140 and 250
Grand, C. G., Chambers, R., and Cameron, G. (1935). Cit.
Jackson
Gray, H. (1900). J. comp. Path. 13, 254
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I, 328
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(1933). J. comp. path 46, 186
McGowan, J. P. (1928). Cit. Feldman, and Jackson
Masson, P. (1926). Cit. Ewing
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Ziegler, E. (1908). Cit. Goldberg
Addendum
Since writing, a specimen of bovine malignant
melanoma was added to our collection (Spec.
115/1938). The material was from a cow said to
have died of generalized multiple melanomatosis.
The history of the animal was that it had develop-
ed, about a year before death, a 'tumour-like
ulcer' on the hind quarter of the udder, which
healed up in a few days. Six months later, the
cow calved and after two months the lesion re-
curred, rapidly becoming large and producing
febrile symptoms with progressive emaciation and
dyspnoea. The cow was operated on for 'abscess'
On opening the lesion, a yellowish fluid escaped
and a soft tumour with very deep extensions was
removed. The patient died the next day and
revealed at autopsy multiple black nodules in all
internal organs, especially in the lungs, liver and
kidneys. The colour and age of the cow could not
be ascertained.
SELECTED ARTICLES
BOVINE TUBERCULOSIS IN THE TROPICS WITH SPECIAL
REFERENCE TO UGANDA, PART II*
By J. CARMICHAEL, D.Sc., M.R.C.V.S., Dip. Bact. (London), Colonial Veterinary Service
EXPERIMENTAL TUBERCULOSIS IN ZEBU CATTLE
IN part I† of this paper attention has been
drawn to the very low incidence of tuberculosis
in Zebu cattle in India and Tropical Africa. This
remarkable paucity of tuberculosis does not, how-
ever, apply to all cattle in warm climates, for in
Uganda there is the Ankole breed of cattle
in which tuberculosis has proved to be extremely
widespread.
*Reprinted by permission of the Publishers from the
Veterinary Journal Volume 97, No. 10, October 1941
† Journal of Comparative Pathology and Therapeutics
Vol. 52, Part 4, pp. 322-335, December, 1939.