vi
Vaccine Therapy.—This part of the Work has expanded greatly and most.
encouraging results have been got in a considerable variety of cases. The demand
often exceeded our capacity to supply and vexatious delays occurred on this account.
Seventeen autogenous vaccines were prepared and their nature and the results got
with them are shown in table III.
TABLE III.—Autogenous vaccines supplied during 1910.
N u m
ber.
Nature of case.
Used by
Description of organism isolated.
Result.
1
Acne ..
..
.. Colonel Gifford, I.M.S.
Staphylococcus albus and aureus
mixture.
Cured.
2 Suppuration in knee
joint in a case of
Pyernia.
Mission Hospital, Ikkadu,
Tiruvallur.
Staphylococcus aureus
..
.. Not known.
3
Boils ..
..
.. Major Elliot, I.M.S. ..
..
Do.
..
.. Cured.
4
Syeosis
..
.. Captain Hoar, R.A., M.C. .. Coccus big ?
..
..
.. Improved.
5 Boils ..
..
.. Direc t or, the King Institute .. Staphylococcus albus
..
.. Cured.
6
Boils ..
..
.. Colonel Gifford, I.M.S.
..
Do.
..
.. Cured.
7
Boils ..
..
..
Do.
.. Staphylococcus aureus which
develops colour slowly.
Cured.
8 Joint affection
.. Civil Surgeon, Ootacamund .. Staphylococcus aureus?
..
.. Patient left before
vaccine was
ready.
9 Pelvic cellulitis
.. Miss McPhail ..
..
.. Staphylococcus aureus (which
looked like capsulated diploco-
ceus in the original specimen).
Cured.
10 Boils ..
..
.. Colonel Gifford, I.M.S.
.. Staphylococcus albus and aureus
mixture.
Cured.
11 Pemphigus ..
..
Do.
.. Diplococcus—Special
..
.. Not known.
12 Acne ..
..
.. Captain Forrest, I.M.S.
.. Coccobacillus which ferments only
glucose and no other sugar.
Under treatment.
13 Renal suppuration .. Colonel Gifford, I.M.S.
.. Organism resembling Pneumo-
coccus .
Cured.
14
Acne ..
..
..
Do.
.. Two organisms named P 4 and P5
, a t y p i c a l S t a p h y l o c o c c u s a l b u s .
Cured.
15
A cne ..
..
.. Captain Ingram, I.M.S.
.. Two organisms named C4 and C5 ,
a typical Staphylococcus albus.
Improved.
16
Chronic nasal dis-
charge.
Military Assistant Surgeon
Leffranais, Poonamallee.
Streptococcus brevis
.. •
Cured.
17 Boils ..
..
.. Colonel Gifford, I.M.S .
..
Staphylococcus albus
..
.. Cured.
The list includes a considerable number of cases of furunculosis and of acne.
It was more usual to isolate Staphylococcus aureus from the former and Staphy-
lococcus albus from the latter, but occasionally mixtures of the two were got. More
striking however was the great diversity of appearance displayed by different strains,
both in the actual discharges and in culture. Whether these differences indicate
distinct species it is hard to say, but time was not available to go into the question
fully. The experience of vaccine therapy in India being but small, the doses recom
-
mended were much smaller than those usually given in Europe. More than fifty
million cocci were rarely given as an initial dose, and often much less was prescribed.
Cases of acne especially did not do well with large doses and ten million cocci was a
common initial dose. In cases of furuneulosis a remarkable feature was the great
rapidity of the effects produced. Cases of considerable duration showed marked
amelioration in a few hours and in most two or three days was sufficient to effect a
cure. Some of the cases presented special points of interest.
Case 4 is one of very long standing and had been treated without permanent
benefit in England with mixed vaccine of Staphylococcus aureus, albus. Two organisms
were isolated, of which one only seemed to exercise any action on the condition. This
was culturally very like Staphylococcus albus but morphologically was two or three
times the size. The small dose of ten million cocci produced marked exacerbation, so
after a while doses of one million were given with good effect. After the treatment
had lasted for some time four million was found to be still too much, so the dose was
again reduced.
Case No. 9 was a post operation case with a remittent temperature of a persistent
type. Microscopical examination of the discharge showed a diplococcus, but on
cultivation this developed into what looked just like Staphylococcus aureus.
Following each injection there was a fall of temperature and a good recovery was
m a d e .
Case No. 12.—This was a troublesome condition affecting chiefly the scalp and
back. The pustules were large and inflamed but of an indolent type, persisting
for a long time. On two occasions, at a considerable interval, an organism resembling