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three doses of 15 gm. each or three to five
doses of 10 gm. each should be given in bran.
Intravenous injections of Stavarsol destroy
the larvæ of strongyles and cyclicostomes. The
dose is 5 gm. repeated three to ten times.
Lang [1936] claims that, intravenous injec-
tions of 5 per cent sodium chloride and 5 per
cent sodium citrate, in 2 pint doses, destroy
the thrombus formation.
HELMINTHIASIS IN DOGS
Hexyl-resorcinol has been shown to be effec-
tive against ascarids and hookworms. It is
irritating to the mucous membrane and should
be administered as a powder. It decomposes
gelatin and is ineffective when mixed with oil.
It is administered in freshly filled gelatin cap-
sules or in sugar coated tablets. The dose is 250
mg. per kilo. of body-weight.
Hexylmetacresol is said to have all the good,
and none of the bad, qualities of hexylresorcinol.
Carbon tetrachloride has been found to be
very effective against hookworms and has in
recent years become very popular. The dose is
0.3 c.c. per kilo. of body-weight and is ad-
ministered in gelatin capsules, with the neces-
sary precautions (see-distomiasis).
Some workers claim that a mixture of carbon
tetrachloride and oil of chenopodium in the
proportion of 2 c.c. of carbon tetrachloride and
20 min. of oil of chenopodium is more effective
than the former alone. Both drugs can be
given mixed in the same capsule, followed an
hour later by a dose of magnesium sulphate.
It is said that the drugs are supplementary to
one another, and for this reason the dose of
each individual drug can be reduced. The
toxicity of the combination is not greater than
that of the drugs themselves when administer-
ed separately.
One c.c. of chloroform mixed with 30 c.c. of
castor oil has been recommended for ancy-
lostomiasis.
Phenothiazine is useful for ascarids, hook-
worms and whipworms. The dose is 3-10 gm.
It is not toxic.
The injection of at least one gm. of pheno-
thiazine in the vicinity of a Dracunculus ulcer
reduces invalidism and hospitalization. The
drug should be made into an emulsion with
olive oil. water and adeps lanæ.
Prontosil, in combination with emetine hydro-
chloride, brings about a rapid and redical cure
in dogs infested with Paragonimus westermanii.
Hydrogen peroxide, sodium permanganate
and sodium hyperborate are said to be effective
against most of the worms of dogs and are quite
safe. It has been claimed that a rectal injec-
tion of 1.5 c.c. removed all tapeworms (either
vomitted or passed in fæces) and most other
worms. There were no ill effects.
Arecoline hydrobromide has proved to be the
drug of choice in the treatment of tæniasis of
dogs. The dose is 2 mg. per kilo. of body-
weight. The drug frequently
causes nausea
and vomitting and is best administered in
gelatin capsules together with chlorotone (about
5 grains per 10 kg.). The worms are passed
within 10 to 20 minutes. Nosik [1940] states
that arecoline hydrobromide in doses of 0.002
to 0003 gm. per kilo. followed by the extract
of male fern in a dose of 0.2 to 0.3 gm. per
kilo. and repeated after 10 days is 100 per cent
effective against Echinococcus granulosus and
other Tænia- spp. It has some effect against
ascarids, but is ineffective against Mesoces-
toides.
Iso-amyl-ortho-cresol
is specific
against
Dipylidium caninum. The dose is 0.1 c.c. per
lb. of body weight, followed by a dose of magna-
sium sulphate.
Brooks and Brown [1942] consider that ficin
is 100 per cent effective against ascarids, 96
per cent against Trichuris dispar and only
13.6 against Ancylostoma caninum. It is totally
ineffective against Dipylidium caninum. The
dose is 750 to 1,000 mg. of the drug per kilo.
of body-weight to be given as a 15 per cent
aqueous suspension by a stomach tube, followed,
three to four hours later, by 1 gm. of Epsom salt
per kilo. in a saturated aqueous solution.
Gentian violet has been recommended for
Strongyloides stercoralis of dogs as it has been
for man. The dose is 15 to 17 mg. per kilo.
body-weight.
N-butyl chloride in a dose of 0.3 c.c. per
kilo. body-weight is useful against hookworms
and ascarids. Wright et al. [1933] states that
a rectal injection of 1 oz. per 20 lb. of body-
weight removes all cæcal worms.
N-butyl bromide and N. amyl bromide are
stated to be 100 per cent effective against
Ancylostoma caninum.
'Rotenal' (the active principle of Degvelia) is
useful against hookworms and ascarids of dogs,
in doses of 0.2 gm. per kilo of body-weight.
'Nemural', a pyridine derivative, is effective
against tapeworms of dogs. The dose is 18 mg.
per 15 lb. of body-weight. A tablet dissolved
in water can be given after a light meal and
should be followed by an enema.
No laxative
is necessary. The drug is not toxic. The
tapeworms, especially Dipylidium
caninum.