NationalLibraryOfScotland/medical-history-of-british-india huggingface dataset:
108 THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY [ II, II
It will be observed that it was only in one case that lesions did not develop,
but as comparatively small doses of the drug had been administered the results
were considered inconclusive.
On the 27th September 1926, 5 or 6 out of 30 bulls accommodated in the
Silinguri Kraal on the Muktesar estate were reported to be suffering from Foot-
and-Mouth Disease. The bulls were examined on the following day and 22 of them
were found to be showing well-defined lesions of the disease. A method regarded
by Walker and Taylor to be worthy of consideration for the purpose of con-
ferring immunity against Foot-and-Mouth Disease is to inoculate all contact
animals with virus and inject them with Iodine, as soon as they have begun to
show an elevation in their temperature. In the present outbreak an attempt was
made to test the value of this method on the remaining 8 bulls, which as yet
showed no signs of the disease, but instead of inoculating them with virus, infec-
tive material, consisting of saliva and material from lesions from the affected
animals, was rubbed into the mucous membrane of their mouths. They were then
divided into two lots of 4 each. One lot was immediately injected with 100 c.c. of
Lugol's solution intravenously, and this was followed by two more injections on
the 30th September 1926 and 11th October 1926 respectively, the injections in all
cases being well tolerated. The animals of the other lot were kept as controls and
received no treatment. The results are recorded below :—
CONTROL OF FOOT-AND-MOUTH DISEASE
109
TABLE II.
Treated Animals.
No. of Animal.
H. B. 924
....
H. B.939
....
H. B.916
....
H.B.913
....
28th September 1926
Temp.
A.M. P.M.
*
Not record-
ed.
*
Do.
*
Do.
*
Do.
Lesions
F
—
—
—
—
M
—
—
—
—
29th September 1926
Temp.
A.M.
102.8°
103°
101.4°
101.4°
H. B. 915
....
H. B. 925
....
H. B. 923 ....
H. B.934
....
Do.
Do.
Do.
Do.
—
—
—
—
—
—
—
—
102°
101.6°
101.4°
103 6°
P.M.
104°
104.4°
103.2°
102.8°
Lesions
F
—
—
—
—
M
—
—
—
—
30th September 1926
Temp.
A.M.
*
103.8°
*
104°
*
103°
*
102.4°
P.M.
104°
105°
104. 4°
103.6°
Controls.
102.4°
103.6°
102.8°
104.6°
—
—
—
—
—
+ +
—
—
102°
102.6°
102.6°
103.4°
1038°
105.6°
104.8°
105°
Lesions
F
—
—
—
—
M
—
—
—
+ +
1st October 1926
Temp.
A.M.
102.4°
103°
102.4°
100. 6°
P.M.
1026°
102.6°
103.8°
103.2°
Lesions
F
—
—
—
—
M
—
—
+ +
+ +
2nd October 1926
Temp.
A.M.
101.8°
101.8°
103°
104°
P.M.
102.2°
102.2°
102.4°
103°
Lesions
F
—
—
—
+
M
—
—
+ +
+ +
—
—
—
—
+ +
+ +
—
—
100.6°
102.2°
1026°
102°
104°
103.8°
102.8°
102.4°
—
+ +
—
—
+ +
+ +
—
—
103.8°
103. 6°
102°
101.8°
103°
103.2°
103.2°
102°
—
+ +
—
—
+ +
+ +
—
—
110 THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY [ II, II
TABLE II—contd.
Treated Animals.
No. of Animal.
H.B. 924 . . . .
H. B.
939
.
.
.
.
H. B. 916 . . . .
H. B. 913 . . . .
H. B.915
.
.
.
.
H. B. 925 . . . .
H.B. 923 . . . .
H. B. 934 . . . .
3rd October 1926
Temp.
A.M.
102.4°
102.4°
102.4°
100.6°
102°
100.6°
101°
101°
P.M.
103.8°
103.8°
103.4°
103.6°
104.2°
102.6°
103°
103.4°
Legions
F
—
—
—
+
+
+ +
—
—
M
—
—
+ +
+ +
+ +
+ +
—
—
4th October 1926
Temp.
A.M.
102°
104.2°
102.8°
102.6°
102.6°
101°
101.6°
102°
P.M.
104°
103.8°
103.8°
104.6°
Lesions
F
—
—
+
+
M
—
—
+ +
+ +
5th October 1926
Temp.
A.M.
102.4°
102.6°
102°
103°
P.M.
103.6°
103.8°
102.6°
103.4°
Controls.
104.6°
103.8°
104.6°
104.4°
+
+ +
—
—
+ +
+ +
—
—
102.6°
101.8°
103.2°
102°
102.8°
102.6°
102.2°
103°
Lesions
F
—
—
+
+
+
+ +
—
—
M
—
—
+ +
+ +
+ +
+ +
—
—
6th October 1926
Temp.
A. M.
103°
104.6°
101.8°
102.4°
102.4°
101.4°
101°
102.4°
P.M.
104°
104.8°
104 4°
1024°
103.6°
104.6°
105°
103.8°
Lesions
F
—
—
+
+
+
+ +
—
—
M
—
—
+ +
+ +
+ +
+ +
—
7th October 1926
Temp.
A.M.
101.6°
102.2°
101.4°
101.2°
102°
101°
102.2°
102.4°
P.M.
103.6°
104.2°
103.4°
104°
103.6°
104°
104.6°
104.2°
Lesions
F
—
—
+
+
+
+ +
—
—
M
—
—
++
+ +
+ +
+ +
—
—
CONTROL OF FOOT-AND-MOUTH DISEASE
111
TABLE II—concld.
Treated Animals.
No. of Animal.
H. B.924 ....
H. B. 939
....
H. B.916
....
H. B. 913
....
8th October 1926
Temp.
A.M.
101.8°
102°
101.6°
101.4°
P.M.
104.4°
104.4°
103.8°
103.6°
Lesions
F
—
—
—
+
M
—
—
+ +
+
+
9th October 1926
Temp.
A.M.
102°
101.8°
102°
101°
H. B. 915 ....
H. B. 925 ....
H.B. 923 ....
H.B.934 ....
102°
101.2°
101.4°
102°
103.6°
103.8°
104.6°
104.2°
+
+ +
—
—
+ +
+ +
—
—
102.2°
101.6°
101 8°
101.8°
P.M.
104.4°
104.4°
103.6°
103.6°
Lesions
F
—
—
—
+
M
—
—
+ +
+ +
10th October 1926
Temp.
A.M.
100.2°
100.4°
100.8°
99.8
P.M.
103.6°
103 .8°
103.6°
104°
Controls.
104°
103.8°
104.6°
104°
+
+ +
—
—
+ +
+ +
—
—
99.8°
100°
101°
100.2°
103.8°
104°
104.2°
103.6°
Lesions
F
—
—
—
—
M
—
—
+ +
+ +
11th October 1926
Temp.
A.M.
*
101.2°
*
101°
*
101.2°
*
100.8°
P.M.
...
....
...
...
Lesions
F
...
...
...
...
M
...
...
...
...
Remarks
All animals received
100 c.c. of the
Solution on the
dates mentioned.
+
+ +
—
—
+ +
+ +
—
—
101.6°
101.4°
101°
101.2°
...
...
...
...
...
...
...
...
...
...
...
...
112 THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY. [ II., II.
The temperatures of the animals were not recorded on the 28th September
1926 at the time of injection, but all the animals showed a rise the following day
and one of the controls had developed mouth lesions. It is not possible to say,
therefore, whether the animals received their infection naturally or through the
infective material rubbed into their mouths but this is immaterial for the purposes
of this test. The important point is that the 4 treated animals received their
first dose of Iodine before the appearance of lesions.
It will be seen that out of the 4 animals injected with Iodine, Nos. 924 and
939 did not develop the disease, whilst No. 913 showed lesions on the 30th Septem-
ber, and No. 916 on the 1st October. The attack in these two cases was, however,
mild and the foot lesions were very slight. Both bulls completely recovered from
the disease on the 15th day and the 13th day respectively. The two controls,
Nos. 915 and 925, which developed the disease, had it in a slightly more severe
form than the two injected bulls, but they recovered in 18 days. Although the
disease failed to appear in two of the treated animals, it would seem hardly pos-
sible to ascribe this to the effect of the drug, seeing that two of the untreated
animals also escaped infection, so that the possibility is not excluded that both
the two treated and untreated animals were naturally resistant to the disease.
An outbreak was also reported from Bhulmaria Kraal on 30th September 1926,
and on examination on the following day, 20 bulls out of 29 were found to have
developed conspicuous lesions of Foot-and-Mouth Disease. The remaining 9 bulls,
which were without lesions, were artificially infected on this date by means of
saliva and material derived from lesions in the same manner as described in the
preceding outbreak. Five of these were then immediately treated with Iodine,
the treatment being repeated two days later; the other 4 were kept as controls.
In the course of 24 hours, following the first injection of the drug, two of the
treated animals developed mouth lesions, while two others eventually developed
both foot and mouth lesions. The remaining treated animal did not develop any
symptoms of the disease throughout the entire observation period. The average
period taken for recovery by the above 4 animals was 15 days. All the 4 controls
developed the disease, three of them showing lesions on the 1st day and the
fourth on the 3rd day. All had both the feet and mouth affected, the lesions were
much more severe than in the case of the treated animals, and one of them died.
The results in the above two tests lend some support to the view that, although
the drug will not with certainty avert the development of lesions, as claimed,
it may, if given in good time, exert sufficient tonic action to help an animal
over an attack of this disease. The details of the Bhulmaria outbreak are seen
in Table III.
CONTROL OF FOOT-AND-MOUTH DISEASE
113
TABLE III.
Treated Animals.
No. of Animal
H. B. 905 . . .
H. B. 897 . . .
H. B. 903 . . .
H. B. 907 . . .
H. B. 865 . . .
1 st October 1926
Temp.
A.M.
...
...
...
...
...
P.M.
*
102.4°
*
102.6°
*
102°
*
103.4°
*
103.4°
Lesions
F
—
—
—
—
—
M
—
—
—
—
—
2nd October 1926
Temp.
A. M.
102°
103.8°
102.4°
102°
102.8°
H. B. 891 . . .
H.B. 871 . .
H. B.896 . . .
H. B. 879 . . .
...
...
...
...
103.2°
104°
103.4°
10.4°
—
—
—
—
—
—
—
—
104.4°
105°
103°
105°
P.M.
102.6°
104°
103°
102.8°
102.4°
Lesions
F
—
—
—
—
—
M
—
—
+
+
—
Controls.
104.6°
104.8°
102.6°
105.4°
—
—
—
—
+
+
—
+
3rd October 1926
Temp.
A.M.
*
105°
*
104°
*
106°
*
103.6°
*
105°
P.M.
105.4°
105°
105°
104.6°
105.6°
Lesions
F
+
—
—
—
—
M
+ +
—
+ +
+
+
4th October 1926
Temp.
A.M.
103.4°
101.8°
101.4°
101.4°
102.4°
P.M.
104°
103°
103.6°
102.8°
102.8°
Lesions
F
+
—
—
—
+
M
+ +
—
+ +
+
+ +
104.8°
105.2°
105°
104.8°
105.4°
104.6°
104.2°
105.8°
+ +
—
—
—
+ +
+ +
—
+ +
100.8°
101°
101.4°
101.2°
102.4°
102.8°
103.6°
102.8°
+ +
—
—
+ +
+ +
+ +
+ +
+ +
114 THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY. [ II, II.
TABLE III—contd.
Treated Animals.
No. of Animal
H. B. 905 . . .
H. B. 897 . . .
H. B.903 . . .
H. B.907 . . .
H. B. 865 . . .
5th October 1926
Temp.
A.M.
102.6°
101.2°
106°
102.2°
102.8°
P.M.
103°
101.6°
104.2°
101.6°
103.3°
Lesions
F
+
—
—
—
+
M
+ +
—
+ +
+
+ +
6th October 1926
Temp.
A.M.
102°
101°
103°
101°
101.8°
H. B.891 . . .
H. B. 871 . . .
H. B. 896 . . .
H. B.879 . . .
102.8°
102°
104°
101°
101°
101.8°
101.6°
101.8°
+ +
+ +
+ +
+ +
+ +
+ +
+ +
+ +
99°
100.8°
101°
100.2°
P.M.
104.4°
103.8°
104.8°
103.6°
104.6°
Lesions
F
+
—
—
—
+
M
+ +
—
+ +
+
+ +
Controls.
98.4°
104°
103.8°
104°
+ +
+ +
+ +
+ +
+ +
+ +
+ +
+ +
7 th October 1926
Temp.
A.M.
103°
102.8°
104°
102.2°
103°
P.M.
103.8°
104.2°
105°
104°
104.8°
Lesions
F
+
—
—
—
+
M
+ +
—
+ +
+
+ +
8th October 1926
Temp.
A.M.
101°
101.6°
103.4°
103°
102.6°
P.M.
104.6°
104°
104°
103.8°
105°
Lesions
F
+
—
—
—
+
M
+ +
—
+ +
+
+ +
—
102°
101°
102°
—
103.6°
103.4°
102.8°
—
+ +
+ +
+ +
—
+ +
+ +
+ +
—
101.4°
101.8°
102.4°
—
103.6°
104.4°
104.8°
—
+ +
+ +
+ +
—
+ +
+ +
+ +
CONTROL OF FOOT-AND-MOUTH DISEASE
115
TABLE III—concld.
Treated Animals.
No. of Animal
H. B. 905 . . .
H. B. 897 . . .
H. B. 903 . . .
H. B.907 . . .
H. B. 865 . . .
H. B. 891 . . .
H. B. 87l . . .
H.B. 896 . . .
H.B. 879 . . .
9th October 1926
Temp.
A.M.
102.2°
102.2°
102.6°
102°
102.6°
—
102°
102.6°
101.8°
P.M.
104.4°
104°
104.2°
103.8°
104.6°
—
103.6°
104.4°
104.6°
Lesions
F
+
—
—
—
+
—
+ +
+ +
+ +
M
+ +
—
+ +
+
+ +
—
+ +
+ +
+ +
10th October 1926
Temp.
A.M.
101.8°
101.6°
100.6°
102°
101.6°
P.M.
103.6°
103.2°
102.8°
103.4°
102.8°
Lesions
F
+
—
—
—
+
Controls.
—
102.2°
102.8°
102°
—
103°
103.8°
103.2°
—
+ +
+ +
+ +
M
+ +
—
+ +
+
+ +
—
+ +
+ +
+ +
11th October 1926
Temp.
A.M.
102.8°
102.8°
102.2°
102.4°
101.8°
—
101°
102°
101°
P.M.
...
...
...
—
—
—
Lesions
F
...
...
—
—
+
—
+ +
+ +
+ +
M
...
...
+ +
+
+ +
—
+ +
+ +
+ +
Remarks.
} All injections were 100 c.
c. of Lugol's solution on
the dates mentioned.
Died during the night of 6th
October 1926.
B
116 THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY [ II, II
Concurrently with the above experiments, the therapeutic effect of Lugol's
Iodine solution was tested upon the 22 animals at Silinguri and the 20 at Bhul¬
maria that had developed lesions of the disease before treatment could be applied
to them. The 22 animals of Silinguri received two injections of the drug intra-
venously of 100 c.c. each, one on the 28th September 1926 and the other on the
11th October 1926. All the animals recovered in the course of an average period
of 20 days, although the lesions in most cases were rather severe, being observable
on both the feet and mouth. The 20 affected animals at Bhulmaria received a
single injection of 100 c.c. of Lugol's solution each, intravenously, but the outbreak
took a virulent form and 9 out of the 20 animals, all of which were already in a
poor and debilitated condition, eventually succumbed to the disease. This seems
to indicate that the drug is of no use when applied under the above conditions.
No further work was carried out to test the efficacy of Walker and Taylor's
method until 1930. In April of that year, 83 hill bulls were purchased and ac-
commodated in Sitla Kraal attached to this Institute and on the 26th of that
month, 19 of the animals were found to have developed mouth lesions of the
disease. It was therefore decided to give an intravenous injection of Lugol's
solution to a proportion of the remaining 64 animals as soon as they exhibited a
temperature of 102° F. or above. Accordingly, 35 animals which showed the re-
quired elevation of temperature received single injections of the drug on various
dates between 26th April and 4th May, in accordance with the following scheme
of dosage:—
Animals weighing upto 150 lbs. . .
Animals weighing from 151 to 200 lbs. .
Animals weighing over 200 lbs. .
. .
.
.
. .
.
.
.
.
. .
. 50 c.c.
. 80 c.c.
.
100 c.c.
Out of the 35 treated animals, it was found that 28 had already developed
commencing lesions of the disease, although it is believed that in the majority of
these cases the lesions had appeared only on the day of injection, and the interval
between lesion formation and drug injection must, therefore, have been so short
as hardly to interfere with the action of the drug. As a matter of fact, Walker
and Taylor have included in their protocols a case in which the progress of the
disease is reported to have been completely arrested even when the drug injection
was given after appearance of a " small vesicle on surface of tongue ". In any
case, there were in the present trial at least 7 animals which received the drug at
a stage in the progress of the disease which was strictly in accordance with the
recommendations of Walker and Taylor, for, while exhibiting definite febrile
symptoms, none of these 7 animals had at the moment of injection developed lesions
of the disease.
CONTROL OF FOOT-AND-MOUTH DISEASE
117
The remaining 29 animals were left untreated as controls along with the 19
originally affected animals. The entire lot of 83 animals may, therefore, be
classified under the following categories :—
Lot A. 7 animals that received drug treatment during the febrile stage of the
disease and definitely before lesions had appeared.
Lot B. 28 animals that received drug treatment on the day of the first ap-
pearance of the lesions.
Lot C. 29 animals that were left untreated as controls.
Lot D. 19 animals that were found affected with lesions shortly after they
were purchased. These were also left untreated.
The records of observations on the animals of these four categories are sum-
marised in the following Table :—
B 2
118 THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY [ II, II
TABLE IV.
Lot
TREATED.
UNTREATED.
A.
B.
C.
D.
Particulars of lot
7 animals treated dur-
ing febrile stage before
appearance of lesions.
28 animals treated on
day of appearance of
lesions.
29 animals left untreated
as controls.
19 animals found affect-
ed with lesions shortly
after purchase.
Left
untreated as controls.
Number of
deaths
0
4 or 14.3%
7 or 24.0%
2 or 10.5%
Number
of
animals
survived
7 or 100%
24 or 85.7%
22 or 76.0%
17 or 89.6%
Number of
animals that
developed
lesions
6 or 85.7%
28 or 100%
22 or 76.0%
19 or 100%
Number of
animals that
did not
develop
lesions
1 or 14.3%
0
7 or 24.0%
0
Average
duration of
lesions in
animals that
survived
30.3
23.6
23.5
..
Average
duration
of
lesions
}
25
..
..
Remarks
These animals were
found affected with
lesions shortly after
purchase, and it was
not possible to as-
certain the exact
day on which these
had developed.
CONTROL OF FOOT-AND-MOUTH DISEASE
119
An examination of Table V shows that out of the 7 animals (Lot A) which
received treatment during the febrile stage of the disease, only in one was the
development of lesions prevented, and it would seem hardly possible to regard this
single instance as illustrative of the beneficial effect of the drug, seeing that as
many as 7 animals in Lot C, that had received no treatment, also failed to develop
symptoms of the disease. The protocols of the 7 animals of Lot A, together with
those of 7 badly-affected untreated animals for comparison, are summarised in the
Table below and it will be seen that there is little to choose between the symptoms
displayed by the 2 lots :—
120 THE INDIAN JOURNAL OF VETERNARY SCIENCE AND ANIMAL HUSBANDRY [ II, II
TABLE V.
Treated Animals.
Serial
No.
1
2
3
4
5
6
7
No. of
Animal
89
93
101
119
143
153
175
26th April 1930
Temp.
A.M.
100.6°
100.4°
98.6°
100.8°
100.8°
99.6°
98.6°
P.M.
102.2°*
108.2°*
99.2°
104.6°*
102.2°*
100°
99°
Lesions
F
—
—
—
—
—
—
—
M
—
—
—
—
—
—
—
27th April 1980
Temp.
A.M.
100°
103.6°
98°
101.4°
102.4°
99°
100.4°
1
2
3
4
5
8
7
91
120
88
99
112
147
177
98°
99.4°
99.8°
99°
99.8°
99.6°
98.8°
97°
99°
100.2°
99.6°
100.4°
100.2°
99.4°
—
—
—
—
—
—
—
—
—
—
—
—
—
—
98.4°
101.6°
98.8°
97.8°
100°
100.6°
100.4°
P.M.
101°
102°
100.6°
101.4°
101.6°
100°
99.8°
Lesions
F
—
—
—
—
—
—
—
M
—
++
—
+ +
++
—
—
28th April 1980
Temp,
A.M.
99.6°
98°
101.6°
98.8°
98°
100.4°
99.6°
Controls.
99.4°
101.6°
99°
101°
100.8°
99.8°
101.4°
—
—
—
—
—
—
—
—
—
—
—
—
—
—
98°
98°
100°
100.8°
101.6°
101.4°
101.4°
P.M.
103.8°
99.6°
102.6°*
100.8°
101.4°
101.8°*
99.6°
lesions
F
—
—
—
—
—
—
—
M
+ +
—
+ +
+ +
—
—
29th April 1980
Temp.
A.M.
98°
97.6°
98.8°
99.6°
99.6°
100.2°
98.2.
P.M.
99.8°
100 2°
101°
100°
101°
101.8°
99.8°
Lesions
F.
—
—
—
—
—
—
—
M
++
+ +
++
++
+ +
++
—
98.4°
100.2°
98.8°
100.2°
100.6°
101.6°
100.6°
—
—
—
—
—
—
—
—
—
—
—
—
—
—
97.4°
99°
97.2°
97.8°
99.8°
99.6°
98.2°
97.8°
100.6°
100°
100°
97.8°
101.4°
99.4°
—
—
—
—
—
—
—
++
++
++
+ +
+ +
+ +
+ +
CONTROL OF FOOT-AND-MOUTH DISEASE
121
TABLE V—contd.
Treated Animals.
Serial
No.
1
2
3
4
5
6
7
No. of
Animal
89
93
101
119
143
153
175
30th April 1930
Temp.
A.M.
101°
99.4°
101.4°
99.4°
99.8°
102.8°
100.2°
P.M.
101.4°
100.4°
101.4°
100.4°
100.8°
101.6°
101.4°
Lesions
F
—
—
—
—
—
—
—
M
+ +
+ +
+ +
+ +
+ +
+ +
—
1st May 1930
Temp.
A.M.
100°
101.4°
100°
99.8°
100.4°
101.6°
100°
P.M.
102.8°
102.6°
102.8°
100.6°
99.8°
102.6°
104°*
1
2
3
4
5
6
7
91
120
88
99
112
147
177
98°
99.4°
99°
99.6°
100.4°
101°
99.2°
99.8°
100.4°
100.6°
101.6°
100.4°
101.4°
99.8°
—
—
—
—
—
—
—
+ +
+ +
+ +
+ +
+ +
+ +
+ +
99.4°
99 4°
99.8°
99.8°
100.6°
100.6°
99.6°
99.8°
100.6°
102.8°
101.4°
99.8°
102 4°
100.8°
Lesions
F
—
—
—
—
—
—
—
M
+ +
+ +
+ +
+ +
+ +
+ +
—
2nd May 1930
Temp.
A.M.
99.6°
101°
100.2°
99.6°
100°
99.6°
100.4°
P.M.
99.8°
101°
100.8°
100.4°
99.8°
100°
100.4°
Controls.
—
—
—
—
—
—
—
++
+ +
+ +
+ +
+ +
+ +
+ +
99°
95°
101°
101°
100°
100.8°
100°
100°
—
101.4°
104°
100.6°
101°
101°
Lesions
F
—
—
—
—
—
—
M
+ +
+ +
+ +
+ +
+ +
+ +
—
3rd May 1930
Temp.
A.M.
98.2°
100.8°
99.2°
99.6°
99.6°
99.4°
99.2
P.M.
100°
101.2°
100.4°
100°
100.2°
100.2°
100.8°
Lesions
F
—
—
—
—
—
—
M
+ +
+ +
+ +
+ +
+ +
+ +
—
—
—
—
—
—
—
—
+ +
—
+ +
+ +
+ +
+ +
+ +
97°
—
100.4°
100.2°
99.8°
100°
99.8°
98.8°
—
100.8°
101°
100.4°
101.8°
99 8°
—
—
—
—
—
—
+ +
—
+ +
+ +
+ +
+ +
+ +
122 THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY [ II, 11
TABLE V—contd.
Treated Animals.
Serial
No.
1
2
3
4
5
6
7
No. of
Animal
89
93
101
119
143
153
175
4th May 1930
Temp.
A.M.
99°
100.4°
99°
98°
98.4°
98.6°
99.4°
P.M.
100.4°
101.6°
100°
99.8°
99.6°
100.4°
100.4°
Lesions
F
—
—
—
—
—
—
—
M
+ +
+ +
+ +
+ +
+ +
+ +
—
5th May 1930
Temp.
A.M.
100°
101°
101.4°
99.8°
101°
100.6°
99.4°
1
2
3
4
5
6
7
91
120
88
99
112
147
177
97°
—
99°
100°
99.8°
99.8°
99°
101.2°
—
100.4°
100.6°
100.8°
101°
99.8°
—
—
—
—
—
—
—
+ +
—
+ +
+ +
+ +
+ +
+ +
99°
—
99.2°
99.4°
99.6°
100°
100.4°
P.M.
101.2°
102.2°
101.4°
101.4°
101.2°
101°
102.2°
Lesions
F
+
—
+
—
+
—
—
M
+ +
+ +
+ +
+ +
+ +
+ +
—
6th May 1930
Temp.
A.M.
99°
99°
99.6°
99°
98.4°
99.2°
99.6°
Controls.
100.4°
—
104°
101.8°
100.4°
100.8°
101.8°
—
—
—
—
—
—
—
+ +
—
+ +
+ +
+ +
+ +
+ +
99.4°
—
98.4°
99.8°
99.8°
99°
100°
P.M.
1006°
100.8°
100.4°
100.8°
100 2°
100.6°
100.6°
Lesions
F
+
—
+
—
+
—
—
M
+ +
+ +
+ +
+ +
+ +
+ +
—
7th May 1930
Temp.
A.M.
98.6°
100°
99.8°
99.8°
100.2°
99.6°
39.2°
P.M.
100.6°
100.4°
100.2°
100°
100.4°
l00.4°
100.4°
Lesions
F
+
—
+
—
+
—
—
M
+ +
+ +
+ +
+ +
+ +
+ +
—
100°
—
100.6°
100.2°
100.6°
100.4°
100.8°
—
—
—
—
+ +
+ +
—
+ +
—
+ +
+ +
+ +
+ +
+ +
98°
—
98.8°
99.8°
98.3°
99.8°
100°
99.8°
—
100°
100.4°
100°
100.8°
100.6°
—
—
—
—
+ +
+ +
—
+ +
—
+ +
+ +
+ +
+ +
+ +
CONTROL OF FOOT-AND-MOUTH DISEASE
123
TABLE V—concld.
Treated Animals.
Serial
No.
1
2
3
4
5
6
7
1
2
3
4
5
6
7
No. of
Animal
89
93
101
119
143
153
175
91
120
88
99
112
147
177
8th May 1930
Temp.
A.M.
98.4°
99°
100.8°
100.4°
98.8°
99.8°
99.2°
98.8°
—
99°
100°
99.4°
100°
99.8°
P.M.
100.2°
100.6°
101°
100.8°
106.6°
100.8°
100.6°
100°
—
100.2°
101.2°
100.6°
101°
100.8°
Lesions
F
+
—
+
—
+
—
—
—
—
—
—
+ +
+ +
—
M
+ +
+ +
+ +
+ +
+ +
+ +
—
++
—
+ +
+ +
+ +
+ +
+ +
9th May 1930
Temp.
A. M.
99.4°
100.2°
100°
100°
98.4°
99.8°
99.8°
P. M.
102.2°
102.2°
101.6°
101.6°
102.2°
102°
101.8°
Lesions
F
+
—
+
+
+
—
—
M
+ +
+ +
+ +
+ +
+ +
+ +
—
Controls.
98.4°
—
101°
101.4°
99.8°
100.2°
99.8°
101.6°
—
102.2°
102°
101.8°
102°
101.6°
+ +
—
—
—
+ +
+ +
—
+ +
—
+ +
+ +
+ +
+ +
+ +
10th May 1930
Temp.
A. M.
97.4°
98.8°
100.2°
98.8°
98.8°
99.4°
99.6°
98°
—
99°
98.6°
99.6°
100°
100°
P. M.
101.8°
102.2°
102.2°
100.6°
100.6°
101.2°
101.6°
99.8°
—
101.8°
101.8°
102.8°
101.8°
101.8°
Lesions
F
—
—
+
—
+
—
—
+ +
—
—
—
+ +
+ +
—
M
+ +
+ +
+ +
+ +
++
++
—
+ +
—
—
++
+ +
+ +
+ +
Remarks
Received 80 c.c. of the
Solution.
Ditto.
Ditto.
Received 50 c.c. of the
Solution.
Received 100 c.c. of the
Solution.
Received 80 c.c. of the
Solution.
Received 100 c.c. of
the
Solution.
Died on 20th May 1930.
Died on 2nd May.
124 THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY [ II, II
The observations on these 7 treated animals are of special interest inasmuch
as these animals were the only ones in the present trial that received treatment in
strict accordance with the suggestions of Walker and Taylor. An examination of
Table IV shows that considered by the rate of healing of the specific lesions, the
advantage lies with the untreated animals, for while the average duration of lesions
in the case of treated animals (Lot A) is 30.3 days, it is only 23.5 days in the case
of the untreated animals of Lot C.
A further test of the efficacy of Iodine treatment was made in November and
December 1930, and on this occasion an attempt was made to control the disease
by giving injections at 3-day intervals during the early stages of the outbreak.
Twenty-six bulls were purchased from a contractor on the afternoon of 12th
November 1930. One of them had a typical mouth lesion of Foot and Mouth
Disease at the time of purchase, and 2 others showed mouth lesions on re-exami-
nation on the following morning. The remaining 23 bulls were then carefully exa-
mined and were found to be free from lesions or febrile symptoms of the disease.
Twelve of these animals were each given an intravenous injection of 100 c. c. of
Lugol's Iodine solution, which was repeated on the 16th, 19th, 22nd and 25th
November and the other 11 animals, which were utilized as controls, were not
given any injection. The observations made in this test are given in the Table
below :—