NationalLibraryOfScotland/medical-history-of-british-india huggingface dataset:
96
H . M
.
S .
H .
9 31 25.—This observation consisted in prolonged irritation of
the vagus from 9h. 30m. 25s. to 9h. 41m.
5 0 s .
and the administration of chloroform by artificial
respiration from 9h. 31m. 45s. to 9h. 39m. 50s.
T h
e a n i m a l d i e d , b u t t h e h e a r t d i dn
o t
stop finally
till 9h. 44m. 30s. This observation would have
b e e n m o r e s a t i s f a c t o r y i f t h ev
a g u s
i r r i t a t i o n h a d
been kept up until all the residual chloroform in the
lungs had been got rid of by artificial respiration.
The whole experiment is most instructive, as it, like Observation D in Experi-
ment No. 64, proves that inhibition of the heart's action by the vagus prevents the
fatal affects of chloroform poisoning and benefits the heart. The animal in
Experiment 117 was put into a condition of extreme danger, from which it could
only be restored by means of artificial respiration, by inhalation of chloroform for
little over one minute (vide Ludwig I., 8h. 3m. 0s. and Ludwig II., 8h . 53m. 30s)
The same animal recovered spontaneously and readily after five minutes of
chloroform inhalation, with inhibition of the heart produced by electrical
stimulation of the vagus. At 8h. 29m. 20s. (vide Ludwig II.) chloroform was
pushed for seven minutes during continued irritation of the vagus, and the
animal came round without artificial respiration. The danger really begins in
these cases when the irritation is discontinued or fails to inhibit the heart, and
thus enables the residual chloroform in the lungs to be rapidly absorbed and
t hrown i nt o t he syst em (v i d e
L u d w i g I I I
. , 9
h. 22m. 0s. to 9h. 25m. 0s).
November 25th. —No.
118.
Monkey (Macacus). Weight 11 lbs. Temperature of the room 24·5 Cent.
Into chloroform box al 10h. 27m. 27s. Fallen down at 10h. 32m. 25s. Placed
on table at 10h. 32m. 50s. and kept quiet with chloroform. Temperature in
rectum 104· 4 F . a t
1 0 b .
4 2 m . 3 0 s .
A r t e r y l i g a t u r e d
a t 1 0 h . 5 0 m .
5 0 s . C a n u l a
inserted at 10h. 52m. 30s. Both vagi looped with a loose ligature. Connection
made with manometer a few seconds before 10h. 5 8 m. T wo L u d wi g a n d t h r e e
Fick tracings.
Observations. H. M. S .
A.1 0 5 8 5 5 . —Or di nar y c hl or of or m a dmi ni s t r a t i on wi t h vi ol e nt
struggling.
B. 11 3 20.—Irritation of the entire left vagus.
97
H. M. S .
C. 11 33 40. —Irritation of the left vagus and pushing chloroform
at the same time on two occasions.
D. 11 41 40.—Chloroform administration with struggling.
E. 11 42 20. —Imperfect irritation of the right vagus and pushing
chloroform.
The tracing was interrupted by clotting in the tubes just as the irritation
of the vagus and chloroform administration were stopped. The animal breath-
ed spontaneously for a few seconds, but then finally ceased breathing and died.
November 25th.—No. 119.
Temperature of the room 25 Cent. Large pariah, weight 30 lbs., that has
had phosphorus on the previous two days, one grain each day, and had been
chloroformed in the morning by Dr. Rustomji, and is extremely feeble.
I n t o
c h l o r o f o r m
b o x a t a b o u t 2 h . 1 9 m . F a l l e nd
o w n
a t 2 h . 2 1 m .
p l a c e d
o n t h e
table at 2h. 22m. 10s.a n d k e p t q u i e t
w i t h
c h l o r o f o r m .
R e s p i r a t i o n v e r y
f e e b l e
and artificial respiration began at 2h. 24m. 45s.B r e a t h i n g
b e t t e r a t
2 h .
2 5 m .
4 0 s . ( T h e d o g w a s s o f e e b l eg e n e r a l l y
t h a t i t w a s n o t
n e c e s s a r y n o r
a d v i s a b l e
to tie him down on the board in the usual way.) Temperature 99 ·8 F. in the
rectum at 2h. 29m. Connection made with manometer at 2h. 41m. 20s. Four
Ludwig and three Fick tracings.
H . M
. S .
A. 2 42 40.—Chloroform administration; holding breath and gasping;
placing thermometer in the rectum ; struggling.
B. 3 12 55.—Irritation of right vagus and pushing chloroform until
respiration stopped: with spontaneous recovery
(vide Fick 5).
C. 3 23 0.—Irritation of right vagus and, pushing ether(vide
Fick 8).
D. 3 38 20.—Pushin g chloroform, and after the blood-pressure had
fallen, irritating the vagus.
E . 3 4 3 2 0 . —Art i fi ci al respi rat i on.
F . 3 5 3
3 0 . — T r a c h e o t o m y .
98
H . M . S .
G. 3 55 0. —Artificial respiration by bellows apparatus attached to
a tube in the trachea.
H. 4 10 0.—Blowing ether by means of this apparatus directly into
the trachea.
I. 4 13 40.—introduction of chloroform by means of a Junker's
inhaler introduced through the tracheal tube down
to the bronchi, and pushing it until death resulted.
Post-mortem.—Temperature 97·6 F.H e a r t p a l e a n d
rather friable. Liver very pale and soft.
November 25th.—No. 120.
Rabbit that had had 5 minims of liquor atropine an hour before. Into
chloroform box. 1 cubic foot in area, at 4h. 28m. 30s. Drowsy and vessels of
the ear dilated at 4h. 29m. Fallen on its side and whining at 4h. 29m. 30s.
Breathing stopped at 4h. 30m. Taken out at once and artificial respiration
commenced, but this was of no avail though continued until 4h. 38m.
November 26th.—Nos. 121 and 122.
No. 121. Rabbit. 5 minims of solution of atropia sulphate injected into
the thigh at 7h. 10m. 20s.
No. 122. Rabbit that has not had atropine :—
No. 121.
No. 122.
H. M. S
H . M . S .
Both into chloroform at
7 25 15
7 25 15
Fell down on side at
7 27 5
7 27 5
Sat up again at
7 27 30
Continued
on his side.
Strugglingling at
7 27 40
Crying at
7 28 45
Stertorous breathing at
7 29 7
Funds of the eye bluish at
7 29 30
Beating time with feet at 7 30 15
7 30 15
Stopped breathing at
7 31 5
Taken out of box and artificial respiration commenced at
7 31 30
Breathing naturally at
7 32 30
Cornea sensitive at
7 32 45
Taken out of box though still breathing at 7 33 10
Cornea sensitive at
7 34 20
Excited struggling at
7 35 0
At 7h. 38m. the pupils of 122 were more dilated than the pupils of 121.
99
November 26th.—Nos. 123 and 124.
No. 123.
No. 124.
Two small monkeys, weight
7 lbs.
8¼ lbs.
H. M. S.
H. M. S.
Into chloroform in a cubic foot box at
7 53 0
7 53 0
Fallen down at
7 56 30
7 56 30
Struggling at
•••
7 56 40
Taken out of box at
7 57 40
7 57 40
Chloroform to keep quiet at
7 59 40
7 59 40
" Under." Stopped chloroform at
8 0 30
8 0 15
More chloroform again at
8
1 53
8 6 32
" Under." Stopped chloroform at
8
2 30
8 7 50
More chloroform 3rd time On inhaler in front of tracheal
tube at
8 7 50
8 10 30
"Under." Stopped chloroform at
8 7 53
8 11 52
More chloroform, 4th time at
8 11 10
5 21 30
Do.
" Under." Chloroform stopped at
8 11 50
8 23 10
More chloroform, 5th time at
8 16 50
•••
" Under" at
8 18 0
•••
Opened trachea at
8 9 0
8 7 35
Canula inserted at
8 9
5
8 8 4 5
Re-inserted, having slipped out at
5 20 7
•••
Attached to the bellows artificial respiration apparatus,
which was so arranged as to blow air through
a separate bottle into each monkey at
8 23 27
8 23 27
Opening the thorax at
8 24 30
8 24 0
Heart exposed at
8 26 30
8 27 0
Ether in bottle at
•••
8 32 15
...
Chloroform in bottle at
8 32 30
•••
Heart stopped
8 3 9 0
•••*
* Owing to a kink in the tubes No. 124 was killed by asphyxia : his heart only flickering or very feebly
contracting when it was first exposod, but it continued to do so until 10h. 48m. with still a faint contraction of one
corner of the auricle at 11h. 30m.
November 26th.—No. 125.
Monkey (medium-sized Macacus). Weight 11¾ lbs. Into chloroform box
at 9h. 20m. Fallen down at 9h. 29m. 15s. Placed on board at 9h. 29m. 30s.
Kept quiet with chloroform. Trachea opened at 9h. 35m. 30s. Tube inserted
at 9h. 36m. Artificial respiration kept up by bellows apparatus and chest
opened. Attempt to connect with Roy's cardiomyograph failed. Ether began
at 10h. 22m. 10s. Heart contracting very feebly. Fresh air 10h. 24m. 30s.
Heart just moving and no more, Flickering until 10h. 40m.
100
November 26th—No, 126,
Monkey, small, Weight 4¼ lbs, Into box and chloroform given at
10h. 36m, 30s, Fallen down at 10h. 40m, 45s, Trachea opened at 10h, 45m,
5s. and canula inserted. Kept quiet with chloroform. Opening thorax at 11h.
6m. 15s. with artificial_ respiration by bellows apparatus. Heart exposed at 11h,
8m. 30s. 5 cc, of ether into the bottle of the apparatus. Animal " quite out" at
11h. 11m, Cornea insensitive at 11h, 11m„ 50s, Heart's action very rapid at
11h, 13m, 50s., but still acting vigorously, Chloroform, same quantity, at 11h.
16m. 45s. (all the ether had evaporated). Ventricle stopped at 11h. 17m, 45s.
Heart flickering at 11h, 19in, Lungs no longer contracting at 11h, 20m, 30s.
All right again at 11h. 21m, 50s, Lun gs not distending at 11h. 24m. owing
to apparatus breaking down, 3¼ cc, of chloroform remained in the bottle,
November 26th—No. 127.
Small monkey, Weight 4½ lbs,
November 26.--No. 128.
Small monke y . Weight 4¼ llbs.
II, M. H, M. S
Into chloroform box 1 cubic foot capa-
city.
2 32 0
Still standing and licking the glass ...
2 33 45
More chloroform into the box
...
•••
2 35 45
Fallen down
.•.
...
...
• • •
2 37 0
Taken out of box and tied on board
•••
2 37 10
2 38 0
More chloroform in ordinary cap ...
2 30 41
Stopped getting chloroform
...
...
2 40 10
2 40 20
Tracheotomy commenced • •
•
•.• •
2 40
3 5
2 41 5
2 41 53
2 43 3
More chloroform ...
...
...
...
2 43 37
Stopped chloroform..,
...
2 43 58
More chloroform ...... "
.•.
2 45 38
Stoppedagain... •"
2 46 5
*so
Trachea opened
......
2 47 30
2 49 17
Glass tube into trachea
...
...
...
2 50 27
2 51 4
More chloroform on ordinary cap in front
of tube.
2 51 33
Stopped chloroform...
...
.,.
...
2 52 43
Into chloroform box 1 cubic foot capa-
city.
Fallen down.
Taken out of box and tied on to board,
Tracheotomy commenced,
Trachea opened.
Glass tube inserted,
Having chloroform (cap held before tube).
Stopped chloroform.
More chloroform,
Stopped chloroform,
101
No. 127—continued.
H. M. S.
No. 128—continued.
Tube slipped out of trachea
2 53 10
2 53 45 More chloroform.
2 54 15 Stopped chloroform.
More chloroform by mouth
2 54 40
Stopped chloroform
2 55 10
Glass tube inserted again
2 55 31
More chloroform
2 55 52
Stopped chloroform
2 56 28
2 57 43 More chloroform.
More chloroform
2 58 54
Stopped chloroform
2 59 30 Stopped chloroform.
Connected with the bellows-artificial respi
¬ration apparatus.
3 0 0 Connected with the bellows-artificial res
¬piration apparatus.
Opening thorax
3 0 21 Opening thorax.
Chloroform through the bellows
3
0 44 Chloroform through the bellows.
3
1 52 Heart exposed.
Heart exposed
3
2 4
Struggling
3
2 25 Struggling.
3 3 10 Lungs not expanding.
3
3 20 Expanding imperfectly.
Lungs expanding freely
3 4 50 Lungs expanding freely.
3
5 10
Ether into the bottle.
Chloroform into the bottle
3
5 30
Heart distinctly feeble
3 5 25
3 5 38 Heart very rapid.
3
7
7 Jerky action of the diaphragm.
Needle into heart
3 7 20 Needle into heart.
Another needle into heart
3 7 30
3
8 45 More ether into bottle. Cornea sensitive.
Lungs not expanding
3
9 40
Heart stopped
3
12
5
(Post-mortem showed clot at the bifurcation
of the bronchi).
3
14 45
Ether completely evaporated.
3
15 5 More ether into bottle.
3
17 30 Needle barely moving.
3
27 45 Stopped.
November 26th.—No. 129.
November 26th.—No. 130.
Small monkey. Weight 33/4 lbs.
Small monkey. Weight 41/4 lbs.
H. M. S.
Into chloroform box
3 31 32 Into chloroform box.
Drunk
3 34 52 Drunk.
Fallen down
3 34 10
102
No. 129— c o n t i n u e d .
H. M. S.
No. 130—c ont i nue d.
3 34 22 Fallen down.
Taken out of box ...
...
...
...
3 35 7 Taken out of box.
3 35 35 More chloroform.
More chloroform ...
...
...
...
3 36 0 Stopped chloroform.
Stopped chloroform...
...
...
...
3 36 32
3 36 57 More chloroform.
More chloroform ...
...
...
...
3 37 24
3 37 58 Stopped chloroform.
Commenced tracheotomy ...
...
...
3 38 40
3 38 50 Commenced tracheotomy.
Stopped chloroform ...
...
...
...
3 39 0
Trachea opened
...
...
...
...
3 39 48
Glass tube inserted ...
...
...
...
3 40 8
3 40 10 Stopped chloroform (commencement not
noted).
More chloroform ...
...
...
...
3 40 45
Stopped chloroform...
...
...
3 42 0
More chloroform ...
...
...
...
3 43 45
Stopped chloroform...
...
...
... 3 44 47
More chloroform ...
...
...
...
3 46 30
3 46 50 Tube inserted into trachea.
Stopped chloroform...
...
...
... 3 47 25
3 51 0 More chloroform.
More chloroform ...
...
...
...
3 51 52
Stopped chloroform...
...
...
...
3 52 27
More chloroform ...
...
...
...
3 53 15
Stopped chloroform...
...
...
...
3 53 41 Stopped chloroform.
Connected with artificial respiration appara-
tus.
3 55 0
Cornea sensitive
....
...
...
...
3 55 15 Connected with apparatus ; cornea sen-
s i t i ve .
Chloroform through bellows
...
...
3 56 0 Chloroform through bellows
10 minims chloroform into bottle ...
...
3 57 25
3 57 43 10 minims chloroform into bottle.
Cornea insensitive ...
...
.
.
3 58 0 Cornea sensitive.
Opening chest
...
...
..
3 58 15 Opening chest.
Heart fully exposed...
...
...
...
3 59 10
Lungs expanding better
...
...
... 4
0 0
4 0 20 Heart exposed.
5 cc. ether into bottle ... ... ...
4 2 24
4 2 37 5 cc. chloroform into bottle.
Needle into heart ...
...
...
...
4 2 57
Heart beating rapidly, communicating
movements to the abdominal wall.
4 3 30 Heart very feebly beating.
103
No. 129 —continued.
H. M. S.
No. 130—continued.
4 3 55 Needle into heart.
5 cc. more ether ...
...
•••
•••
4 8 0
4 8 18 5 cc. more chloroform.
Needle moving less vigorously but dis-
tinctly.
4 8 40 Needle barely moving.
4 10 0 Very slightly moving, if at all.
4 10 55 Absolutely not moving.
Needle moving slowly but steadily. More
ether,
4 12 3 After opening pericardium heart again
flickered.
Heart stopped
•••
•••
•••
..
4 12 20
November 27th.—No. 132, 3 lbs.
No, 131, 3 1/2 lbs.
Medium-sized monkey.
Medium-sized monkey.
Into chloroform box
4 24 20 Into chloroform box.
8 26 0 Drooping.
More chloroform into box ...
...
8 27 18 More chloroform into box.
8 27 47 Fallen against the side.
8 28 50
Down and breathing stertorously.
8 29 55
Taken out of box and tied on to a board.
Fallen down...
...
...
... 8 30 10
Taken out and tied on to a board...
... 8 31 8
8 31 32 More chloroform into the box.
8 32 22 Stopped chloroform and commenced tracheo-
tomy.
More chloroform ...
...
...
... 8 33 20
Stopped chloroform and begin tracheotomy. 8 :34 4
8 34 49 Trachea opened.
8 35 9 Tube inserted into trachea.
8 35 51 More chloroform.
Trachea opened
....
...
8 36 33
Tube inserted
...
...
...
...
8 36 53
Respiration stopped & artificial respiration..
8 37 45
8 38 5 Stopped chloroform.
8 39 15 More chloroform.
6 40 2 Stopped chloroform.
Pressure had probably been made on the
chest by the operator, who had operated
from below and covered the chest with
his hands.
8 13 20
No heart sound audible ; needle into heart..
8 44 15
Needle feebly moving ; continue artificial
respiration.
8 45 10 More chloroform ; struggling.
Abandoned ...
...
...
...
8
46 23 Stopped chloroform.
104
No. 134.
No. 131—continued.
Another medium-sized monkey.
Weight 4 lbs.
H. M. S.
Into chloroform box
...
...
...
8 51 3
Still sitting up and looking about him
...
8 52 46 More chloroform.
Leaning against the side ...
..
...
8 53 37 Stopped chloroform,
Still moving about ...
...
... ...
8 56 23
Fallen down...
...
... ...
...
8 57 58
Taken out of box ...
... ...
...
8 58 5
More chloroform on cap ...
... ...
8 59 0
Chloroform stopped ; tracheotomy begun...
9 1 25 More chloroform.
9 1 52 Stopped chloroform.
Trachea opened
...
... ...
...
9 2 7
Tube inserted
... ...
...
...
9 2 18
More chloroform
...
...
...
...
9 3 9
9 3 29 More chloroform.
9 3 50 Stopped chloroform.
Stopped chloroform...
...
...
9 3 55
Attached to bellows apparatus
...
...
9 4 5 Attached to bellows apparatus.
9 4 31 Opening thorax.
Commenced to open thorax and artificial
respiration begun.
9 5 5 Artificial respiration begun.
A little chloroform into bottle
...
9 6 45
9 6 27 Heart exposed.
More chloroform into bottle
...
...
9 7 27
“ Over " and proceed with operation
...
9 8 0
Heart exposed
...
...
...
...
9 8 57
Pericardium opened
...
...
...
9 9 40 Chloroform into bottle.
9 10 30 Quite over.
9 10 35 Needle into heart.
9 11 20 Bottle emptied.
9 11 35 Needle taken out of heart.
Cornea sensitive
...
... ...
...
9 12 30
9 12 50 Ether into bottle 5 cc.
5 cc. chloroform into bottle
..,
...
9 13 10
Needle into heart ...
...
•••
...
9 13 30 Needle into heart.
9 15 5 5 cc. more ether into bottle.
5 cc. chloroform
...
...
...
...
9 15 45
9 17 0 Heart beating rapidly. Ether all evaporated.
9 17 55 10 cc. more ether into bottle.
5 cc. chloroform
...
...
...
...
9 19 20
Left ventricle hardly acting ; right better
9 21 20
9 21 55 Pericardium removed.
105
No. 134—c o n t i n u e d
.
No. 131—continued .
H. M. S.
Heart feebly flickering
...
...
...
9 22 40
9 24 34 8 cc. ether into bottle.
9 29 43 Another needle into heart.
Needle absolutely still
...
...
...
9 38 0
9 39 55 Connection between needle and a time-
marker (vide tracing).
9 44 15 More ether into bottle.
9 51 5 Artificial respiration stopped (after which
it made spontaneous respiratory move-
ments about every fourth second).
10 0 0 Artificial respiration commenced. H e came
round and breathed spontaneously again
(ride tracing II).
10 24 0 Artificial respiration begun again.
10 27 0 Chloroform into bottle.
10 37 0 Needle taken out. Heart still beating.
10 48 30 Finally stopped, but still remained irritable,
so that it began beating again when needle
was put into it.
November 27th.—No. 133.
Horse thrown and given chloroform on a nose-bag at 10h. 50m. Loop
under right vagus at 10h. 55m. 45s. Right carotid ligatured at 10h. 57m. 40s.
Canula inserted at 11h. 1m. Connection with manometer at 11h. 17m. 55s.
while horse was on the floor. (He was afterwards. 11h. 42m. 30s.. raised on to
the table.)
Two Ludwig and two Fick tracings.
.
A. Ordinary chloroform administration.
B . S l i g h t s t r u g g l i n g .
C. Pushing chloroform until respiration stopped death resulted
in spite of long-continued artificial respiration.
Repeated attempts were made to irritate the vagus, but they failed as the
nerve was never exposed.
November 27th.—No. 135.
Medium-sized monkey. Weight 13 lbs. Temperature of room 23½ Cent.
Into chloroform box at 2h. 22m. 35s. Placed on the table at 2h. 27m. 42s.
and kept quiet with chloroform. Temperature in rectum 102·6 F. at 2h. 37m.
1 4
106
30s. Artery ligatured at 2h. 45m. 25s. Canula inserted at 2h. 48m. 10s.
Loop under both vagi. Connection made with manometer at 2h. 59m. 50s.
Three Ludwig and three Fick tracings.
Observations.
A. Ordinary chloroform administration and struggling.
B. Double ligature and division of the right vagus.
C. Irritation of the central, and
D.
Peripheral. end of the vagus.
E. Injection. of 10 grains of chloral into the peritoneum, and after-
wards irritation of the central and peripheral. end of the right,
vagus.
F. Exposure and ligature of the femoral artery.
G. Opening the trachea and tying a small. glass tube into it.
H.
Closure of the tracheal tube so as to produce almost complete
asphyxia.
I.
Pumping chloroform vapour into the closed tube by means
of Junker's inhaler while the respirations are still embarrassed
and consequent speedy death.
While the chest was being opened, air suddenly rushed in, and it was
thought that spontaneous respiration was going to recommence, but there was no
real spontaneous movement. After death chloroform was injected with much
force into the femoral artery and produced complete rigidity of the limb.
November 25th,—No. 136.
Goat, young male. Weight 16 lbs. Into chloroform box at 10h. 48m. 20s.
Fallen down and taken out of box at 10h. 59m. 20s. Placed on the board and
kept quiet with chloroform. Loop under both vagi. Ligatured the left carotid
at 11h. 9m. 26s. Canula inserted at 11h. 11m. 47s. Temperature in rectum
102•6 at 11h. 18m. 20s. Connection with manometers at 11h, 19m, 20s.
One Ludwig and one Fick tracing.
H. M. S. Observations.
A. 11 11 30.—Ordinary chloroform administration holding breath.
B . 1 1
2 5 1 0 . — P u s h i n g c h l o r o f o r m u n t i l r e s p i r a t i o n h a d a l m o s t
ceased.
C . 1 1 3 0 0 . — G e n e r a l c o n v u l s i o n s ; r e s p i r a t i o n c e a s e d a t 1 1 h . 2 8 m .
20s.
107
H . M . S .
D. 11 30 30.—Artificial respiration was commenced some minutes
after the respiration had entirely ceased and failed
to restore the animal. The case was complicated
b y a
v e r y d i s t e n d e d s t o m a c h a n d t h e f a c t t h a t t h e t r a c h e a w a s f i l l e d w i t h f l u i d a t a n e a r l y s t a g e . I t
was thought that some of the contents of the
stomach found their way into the air passages
during the convulsions or even before they occurred.
A needle was inserted into the heart at 11h. 34m. 0s.
and moved. rhythmically until. 11h. 41m. 40s.
November 28th.—No. 137.
Goat, young male. weight 15 3/4 lbs. Into chloroform box at 11h. 46m.
43s. Fell down at 12h. 2m. 30s. and taken out of box, but still quite sensitive.
More chloroform from time to time to keep it under. Holds its breath like the
other goat whenever chloroform is given. Temperature in rectum at 12h. 8m.,
103.6 F. Artery ligatured at 12h. 11m. 15s. Canula inserted at 12h. 12m. 50s.
Connection with manometer at 12h. 16m. Two Ludwig and one Fick tracing.
O b s e r v a t i o n s .
H . M . S .
A. 12 18 10.—Ordinary chloroform administration showing the effect
on the tracing of holding the breath, and of irregular
jerking respiration.
B . 1 2 2 5 4 0 .
— I r r i t a t i o n o f t h e l e f t v a g u s n e r v e (v
i d e
F i c k 4 )
C . 1 2 3 7 3 0 .
— P
u s h i n g c h l o r o f o r m a n d i r r i t a t i n g t h e l e f t v a g u s(
v i d e
Fick 6).
D . 1 2 4 5 4 0 .
— The same, onl y for a much l onger t i me, aft er whi ch
the animal died in spite of artificial respiration, which
however, for some reason, was never efficient, no air
passing in and out of the chest.
On opening the chest a large quantity of blood was found in the left
pleural cavity.
November 20th.—No. 138.
Temperature of room 20 Cent. Cat, weight 6 1/2 lbs. Into chloroform at
7h. 58m, 5s. More chloroform into the box at 8h. 1m. 55s. Struggling at 8h. 2m.
Fallen down at 8h. 2m. 15s. Tied on to rabbit board and given chloroform
108
from time to time to keep it under. Temperature in the rectum 100 . 6 F. at 8h.
9m. 45s. and artery ligatured. Connection with manometer at 8h. 1m. 25s.
Two Ludwig and one Fick tracing.
Observations.
H . M . S .
A. 8 4 30.—Administration of ether on a cap.
B. 8 34 0.—Struggling.
C. 8 44 30.—Pushing ether until respiration had almost ceased and
only occasional gasping continued.
D. 8 53 30.—Pushing ether with the cap covered with mackintosh
until death ensued.
In this and the next experiment the respiration was registered by a system
of Marey's tambours connected with a pin in the chest wall, the marker running
below the manometer tracing.
November 29th.—No. 139.
Small cat, weight 6¼ lbs. Chloroform given at 9h. 29m. 20s. Fallen
down at 9h. 31m. 45s. Placed on the table at 9h. 35m. 40s. During the
operation of exposing the carotid the cornea was quite insensitive, but there
was whining respiration. Artery ligatured at 9h. 40m. 50s. Canula inserted
at 9h. 42m. 20s. Connection with manometer at about 9h. 50m. 30s. One
Ludwig and one Fick tracing.
Observations.
H . M . S .
A. 9 51 50.—Ordinary chloroform administration.
B. 9 58 50.—Pushing chloroform until death ensued.
The trace was interrupted just before the end by clots in the tube.
November 29th.—No. 140.
Moderate-sized monkey, weight 11¼ lbs. Temperature of the room 21
Cent. Into chloroform in a cubic foot box at 10h. 42m. 15s. Fallen against the
side of the box at 10h. 47m. 20s. A little more chloroform into box at 10h.
48m. 45s. Down at 10h. 49m. 10s. Eyes still blinking. Taken out of box at
10h. 50m. 20s. and kept quiet with chloroform. Temperature 103 F. in rectum.
Canula inserted into carotid 11h. 5m. 30s.