NationalLibraryOfScotland/medical-history-of-british-india huggingface dataset:
84
H . M . S .
F.
10 24 40.—Ordinary chloroform administration.
G.
10 27 15.—Extraction of teeth (Fick 10).
H.
10 42 0.—Blow on the abdomen with a fly-flapper (Fick 13).
I.
10 49 10.—Attempts to pass a grooved staff into bladder.
K. 10 54 0.—Castration.
L. 11 5 0.—Electrical irritation of the spermatic cord.
M. 11 5 40.—Exposing the femoral vessels.
N. 11 16 20.—Transfusion of saline solution, about 220 c.c., into
the femoral vein.
O . 1 1 2 6 0 . — E x p o s i n g a n d d e s t r o y i n g t h e l e f t s p l a n c h n i c n e r v e
and plexus, during which operation the aorta was
accidentally snipped, but the opening was at once
closed by a clamp and very little hæmorrhage
occurred.
P. 11 39 10.—Thrusting a needle into the heart.
Q. 11 43 0.—Pushing chloroform until death with attempted res-
toration by means of transfusion of saline solution
and artificial respiration.
After the thorax was opened and the heart found to have quite ceased
beating, rhythmical movements of the diaphragm occurred. The heart con-
tinued irritable for some minutes. Temperature after death 97.2 F.
In Experiment 103, as well as in Experiments 80 and 92, rhythmical
movements of the diaphragm were noticed after the heart, had ceased beating and
after the chest had been opened. In Experiment 103 the splanchnic nerve had
been divided, death and stoppage of the heart were very gradual, and the heart
was still irritable during the diaphragmatic contractions.
November 20th—No. 104.
A dog, wei ght 361/ 2 l bs. , whi ch had been dosed wi t h phosphorus for t wo
days. Into chloroform box at 2h. 22m. 5s. Fell down at 2h. 26m. 35s. On
the table at 2h. 29m. 30s., and kept quiet with chloroform. Temperature in
rectum 100.4 F. Artery ligatured at 2h. 34m. 7s. Canula inserted at 2h. 36m.
85
7s. Connection with manometer at 211. 40m. 45s. Three Ludwig and three
Fick tracings.
Observations,
H . M . S .
A. 2 41 0.—Struggling at various times.
B. 2 41 30.—Chloroform administration ; violent blow on the
testicle at 2h. 41m. 50s. No shock.
C. 2 42 30.—Slight embarrassment of the respiration, from the
foreleg being tightly bound down to the board
(vide Fick 1 & 2).
D. 2 48 40.—Pushing chloroform until respiration stopped. During
this observation the animal held his breath, the
pulse tracing was immediately lost and the pressure
fell exactly as in the Glasgow experiments A & C.
E. 2 51 10.—Artificial respiration (vide Fick 5), when the normal
respiration was recommencing. The slow pulse is
very noticeable in this observation.
F. 2 53 50.—Change to the vertical position and while vertical more
blows on the testicle, and dental operations were
performed, without the production of shock.
G. 3 2 40. —Incising the abdomen.
H. 3 3 30.—Blowing apomorphia 1-12th grain in solution into the
peritoneal cavity ; vomiting (Fick 9).
I. 3 23 0.—Small opening into the larynx and injection of a few
drops of chloroform.
J . 3 2 6 3 0 . —Pu s h i n g c h l o r o f o r m a g a i n u n t i l r e s p i r a t i o n c e a s e d a n d
artificial respiration (vide Fick 12).
K. 3 34 40.—Seizing and snipping the skin of the anus.
L. 3 35 40.—Larger opening into abdomen and tying a tube into
the stomach.
M. 3 41 40.—Distension of the stomach with air.
N. 3 49 55.—Pulling the stomach forcibly.
0. 3 52 10.—Pushing chloroform very far, and prolonged artificial
respiration.
86
H . M . S .
P. 3 59 10.—Electrical stimulation of the heart.
Q. 4 5 50.—Placing ice on the abdominal cavity.
R. 4 9 0.—Pushing chloroform again until death resulted.
After the thorax was opened 37 rhythmical contractions of the diaphragm
occurred, but the heart continued beating for more than two minutes after
these had stopped. Post-mortem—Temperature 98.2 F. Weight post-mortem
343/4 lbs.
November 21st.— No. 105.
Large-sized pariah dog. weight 301/4 lbs., which has had three doses of
phosphorus previously on the 18th, 19th, and 20th instant, respectively. It
is in consequence very much out of sorts, and, judging from previous experi-
ments with other dogs, would certainly have died in a few hours. Into
chloroform box at 7h. 44m. 25s. Fallen down at 7h. 48m. 55s. Placed on
the table and a canula inserted into left carotid. Temperature in rectum 102 F.
Connection made with manometers at 8h. 9m. 10s. One Ludwig and one
Fick tracing.
O b s e r v a t i o n s .
H . M . S
.
A. 8 12 50.—Pushing chloroform until respiration ceased
(cide
Fick 2 and 3).
B. 8 16 50.—Recovery by artificial respiration.
C. 8 22 35.—Snipping skin of the anus (ride Fick 5). No sign of
shock.
D.
8 24 30.—Ordinary chloroform administration (trace imperfect
owing to the drum sticking).
E. 8 28 55.—Pushing chloroform again and death in spite of arti-
ficial respiration.
The trachea was for some reason considerably obstructed with fluid,
so that the animal was probably in a state of partial asphyxia. Temperature
at death 100.8 F.
November 21st.—106.
Large-sized pariah.Weight 253/4 lbs.Has had three daily doses of
phosphorus on 18th, 19th, and 20th evenings. Given chloroform at 9h. 6m.
Fallen down at 9h. 15m. 30s. On the table at 9h. 16m. Artery ligatured at
87
9h. 25m. 30s. Temperature in rectum 100 . 2 F. Canula inserted at 9h. 29m. 30s.
Connection made with manometer at 9h. 41m. One Ludwig and one Fick
tracing.
H. M. S
Observations.
A. 9 42 20.—Ether administration on cap.
B. 94610.—Pushing ether until respiration stopped. Fick 4
shows exactly the same absence of pulse tracing
which is noted so frequently in chloroform poison-
ing when the respiration stops (vide Experiment
NO. 107, Fick 3, and Experiment No.178—all the
tracings).
C. 9 52 0.—Artificial respiration ; and
D.
9 54 30.—Inversion of the body failed to restore the animal.
Temperature after death 97 . 8 F. Post-mortem.—There was a severe
rupture in the liver and a quantity of blood in the peritoneum. Liver distinctly
soft, friable and pale in colour.
Experiment No. 106 shows the effect of inversion of the body, which is
now-a-days thought to be a restorative in chloroform poisoning. Inversion of
the body causes the pressure in the carotid to rise, but it falls to its former
state when the animal is replaced in the horizontal position. In Observation
D at 9h. 54m. 30s., when the animal was in the last stage of ether poisoning,
inversion of the body raised the pressure in the usual way as long as it was
continued ; but it failed to restore the respiration and the dog died. The
change in the blood-pressure in the carotid, which occurs when the position of
the body is changed, appears therefore to be due simply and solely to the effect
of gravity. Experiment No. 106 also proves that the effect of ether is precisely
the same as that of chloroform only less intense.
November 21st.—No. 107.
Large-sized pariah. Weight 28lbs. Has had two doses of phosphorus
on the 18th and 19th instant, respectively. Into chloroform box at
10h. 9m. 14s. Fallen down at 10h. 14m. 27s. On the table at, 10h. 17m. 30s.
Artery ligatured at, 10h. 24m. 13s. and canula inserted. Temperature, 99.8 F.
in rectum. Loop under both vagi and the right carotid. Connection made
with manometers at 10h. 38m. Pressure much too high ; so much soda solution
must have been shot into the artery (vide Ludwig tracing).
One Ludwig and one Fick tracing.
H. M. S. Obs e r va t i ons .
A. 10 36 0.—Coming out of chloroforms.
B. 10 43 20. —Mi l d i r r i t at i on ( coi l 15) of t he ent i r e r i ght vagus
(Fick 2).
C. 10 44 20.—Pushing chloroform until respiration stopped (vide
Fick 3), pulse tracing absent, this not being a sign
that the heart had stopped; it was restored easily
by artificial respiration.
D. 10 46 0.—Recovery with artificial respiration.
E. 10 51 0.—Ligature and division of the right Tagus (Fick 5).
F. 10 53 10.—Mild irritation (coil 15) of the peripheral end of the
right vagus (Fick 6). Pushing chloroform again
during struggling until death occurred in spite of
artificial respiration.
The temperature in rectum was noted at intervals throughout (vide Ludwig
tracing).
November 21st.—No. 108.
Large pariah. Weight 26 lbs. Has had two one-grain pills of phosphorus
on the 18 and 19th instant, respectively. Into chloroform box at 11h.
23m. Fallen down at 11h. 27m. 45s. On the table at 11h. 30m. 25s. and kept
quiet with ether. Temperature 100.8 F. in rectum at 11h. 33m. Artery
ligatured at 11. 37m. 45s. Canula inserted at 11h. 41m. 30s. Temperature
100.6 F. at 11. 47m. 15s. One Ludwig and one Fick tracing.
H. M. S. Observations.
A. 11 57 40.—Continued ether administration, which failed for a
long time to keep the cornea insensitive, and was
only effectiTe when the animal was half smothered.
B. 12 0 40.—Mild irritation of the entire right vagus, coil 15
(Fick 2).
C. 12 2 0.—Convulsion of the whole body.
D. 12 10 30. —I r r i t at i on of r i ght vagus , coi l 10 ( Fi ck 6) . Thi s
reduced the pulse from 120 to 37 a minute.
E. 12 14 40.—Ligature and division (Fick 7) of the right vagus.
F. 12 16 0.—The ether was pushed until Beath. ensued.
89
Tracing stopped at 12h. 21m. Heart still moving when the thorax was
opened at 12h. 25m. Temperature 97.4 F. Heart flickering at 12h. 27m.
November 22nd.—No. 109.
Medium-sized pariah, weight 27 lbs., that has had three doses of phospho-
rus on the 18th, 19th, and 20th instant, and is in an extremely feeble state.
Chloroformed in the box at 8h. 9m. Fallen down at 8h. 17m. 15s. Placed on
the table at 8h. 19m. 20s. Noticed to have stopped breathing at 8h. 19m. 40s.
Artificial respiration begun at once. Needle in the heart moving feebly at
8h. 21m. 45s. Breaching spontaneously at 8h. 23m. 20s., but artificial respira-
tion continued in the ordinary way. Respiration continued off and on until
8h. 26m. 30s. Needle in the heart afterwards moving slightly, but rhythmi-
cally. The trachea was opened and artificial respiration performed by the
bellows method for a. few minutes, but with no result.
November 22nd.—No. 110.
Medium-sized female monkey, weight 113/4 lbs. (has varicose veins on
abdomen). Into chloroform box at 8h. 51m. Fallen down at 8h. 54m. 15s.
On the table at 8h. 56m. 45s. Temperature in rectum 101.4 F. Artery liga-
tured at 9h. 10m. 5s. Canula inserted 9h. 12m. 45s. Loops under both vagi,
Breathing stopped at 9h. 23m. 50s. Artificial respiration at once and until
9h. 24m. 50s. when breathing became natural again. Stopped breathing again
at 9h. 27m. and artificial respiration performed for some time but without
success. Temperature after death 100.8 F. Post-mortem—The large bronchi
and trachea were filled with blood, and there was a large patch of bloody
effusion in the posterior lobe of one of the lungs.
November 22nd.—No. 111.
Monkey, weight 103/4 lbs., chloroformed in the box 9h. 43m. 50s. Mon-
key fallen down at 9h, 48m. 45s. On the table 9h. 50m. 40s. Artery liga-
tured and canula inserted. Connection with manometer at 10h. 13m. 30s.
Four Ludwig and two Fick tracings.
H. M. S.
0bservations.
A. 10 14 30.—Ordinary chloroform administration on several occa-
sions.
B. 10 20 40.—Small incision into the abdomen and tying a small
tube into the colon (erroneously written "stomach"
on the tracing).
1 2
90
H . M .
S .
C. 10 51 0.—Injection of two doses of half a grain of tartar emetic
into the colon ; struggling.
D. 11 15 0.—Exposing and destroying the left splanchnic cord and
plexus, during which proceeding the animal was
detached from the manometer.
E .1
1 3 4 2 0 . — P u s h i n g c h l o r o f o r m u n t i l r e s p i r a t i o n h a d a l m o s t
stopped.
F . 1 2 8 2 0 . — A p p l i c a t i o n o f h o t a n d a f t e r w a r d s c o l d c l o t h s t o t h e
body.
G . 1 2 1 4 4 0 . — P l a c i n g a c l e a n c a p o v e r t h e
nose.
H. 12 12 30.—Holding ammonia before the nose.
I. 12 20 0. —Pushi ng chl oroform unti l respi rati on ceased.
J . 1 2 2 7 0 . — A r t i f i c i a l r e s p i r a t i o n .
K .
1 2 3 1 2 0 . — E x p o s i n g t h e j u g u l a r v e i n .
L. 12 36 0.—Injection of ammonia, 5 minims of strong ammonia
diluted with 20 minims of water into the jugular.
M .1
2 4 0 0 . — P u s h i n g c h l o r o f o r m f i n a l l y u n t i l d e a t h r e s u l t e d . T h e
declined of blood-pressure was unusually gradual.
The temperature in the rectum had fallen below
95 F. for some time before the end of the
experiment
.
N . B . — R e a d i n g s
m a r k e d
“ C ”
were taken with a second Fick instrument
made by the Cambridge C
o .
To test the effect of shock due to vaso m o t o r c h a n g e r a t h e r t h a n a f f e c t i o n
of the heart Goltz’s experiment on the frog was repeated on three dogs. In one
there was slight lowering of pressure which was not extensive, and in the others
no effect was produced at all. Other operations, which seemed likely to pro
- d u c e s h o c k , s u c h
a sv
i o l e n t b l o w s u p o n
t h etesticle, were singularly devoid of
effect. Failing to lower the blood-pressure by any of these methods, recourse
was had to section of the splanchnics, but the low condition of blood-pressure
this produced appeared, like stoppage of the heart from vagus irritation,
t o b e a
source of safety rather than of danger during chloroform administration. In
t hi s connect i on Experi ment No. 111 may be st udi ed. There was not much
external hæmo r r h a g e , b u t t h e s p l a n c h n i c s we r e d i v i d e d , —a p r o c e e d i n g wh i c h , a s
91
is often said, bleeds the animal into his own vessels. The pressure was after this
extremely low, but chloroform was repeatedly given, and various other actions
taken, and then chloroform had to be pushed on a saturated sponge enclosed in
a cap for eleven minutes before respiration ceased
.
November 22nd.—No . 112
.
Temperature of the room 24 ½ C e n t .
I n t o c h l o r o f o r m
b o x a t
2 h .
4 1 m . 1 9 s .
Fallen down at 2h. 44m. 47s. On the table at 2h. 46m. Observed to have
stopped breathing at 2h. 46m, 10s. Artificial respiration until he was pro
- n o u n c e d
“ d e a d
” a t 3 h . 2 m . N e e d l e i n t h e h e a r tf
a i n t l y m o v i n g
a t
2 h .
54m.
30s.
Post-mortem showed all the signs of asphyxia.
There were thus three acciden tal deaths in the course of this one day,
November 22nd. which it may be noted was exceptional in being a wet day
and was characterised by constant Plunders and mist akes committedby every
one engaged in the experiments and in every department (v i d e
, for example, the
blunders and smudges on the tracings in No. 111) as well as in the administra
-tion of chloroform.
November 22nd.—No. 113
Temperature of the room 24½, Cent. Pariah dog. Weight 38 lbs.
I n t o
t h e c h l o r o f o r m b o x a t 3 h .
5 m .
3 0 s . P l a c e d o n t h e
b o a r d
a t 3 h . 8 m .
1 0 s .
a n d k e p t q u i e t w i t h
c h l o r o f o r m .
A r t e r y l i g a t u r e d a t
3 h .
1 9 m .
1 0 s . C a n u l a
insert
-ed at 3h. 23m. 40s. Temperature in the rectum 100·4 F. at 3h. 2m. 45s.
Connection with manometer
at 3h. 30m. Three Ludwig and two Fick tracings
H . M . S
Observations.
A. 3 30 0.—Chloroform administration and struggling (the trace
is imperfect on account of the drum sticking).
B. 3 32 20.—Cessation of respiration and artificial r e s pi r a t i on.
C. 3 33 25.—Division of the right and then the left v a g u s
.
D. 3 38 0.—Pushing chloroform again until respiration stopped and
restoration by artificial respiration
.
E. 3 39 30.—Exposing the femoral vessels and repetition of (D).
F. 3 51 0.—Ligature of femoral a r t e r y a n d v e i n .
G. 4 3 10.—Hæmorrhage to 170 cc. from the femoral artery and
chloroform again.
H . 4 1 4 2 0 . — T r a n s f u s i o n o f s a l i n e s o l u t i o n i n t o f e m o r a l vein
250 cc. in two doses.
92
H .
M . S
I . 4 2 0 3 0 . — P u s h i n g
c h l o r o f o r m a g a i n
as in D.
J . 4 2 6 5 5 . — H
æ m o r r h a g e
a g a i n 2 5 0 c c . o f b l o o d
tak e n .
K .
4 31 0.—Repetition of the transfusion and pushing chloroform
as before.
Failure to restore the animal in spite of artificial respiration and transf
u - s i o no
f a m m o n i a . T e m p e r a t u r e i n t h e r e c t u m g r a d u a l l y f e l l t o 9 6
·
8 F . a t
death. Post-mortem.— Right heart filled with coagula.
N o v e m b e r 2
3 r d . — N o .
114
Rabbit into cubic foot box with paper saturated with chloroform at 7h.
41m. 10s. Breathing, which was held at first, rapid at 7h. 42m. Fallen on its
side at 7h. 42m. 30s. Breathing stopped at 7h. 42m. 50s. Stopped c h l o r o f o r m
and performed artificial respiration at 7h. 43m. Convulsions at 7h. 44m. Pupils
gradually dilating. Convulsion nearly ceased at 7h. 45m. Came round at
7
h .
4 6 m . N o c o n n e c t i o n
w a sm
a dw
i t hthe recording apparatus, and there is
therefore no tracing.
N o v e m b e r 2 3 r d . — N o
.
115.
M o n k e y . W e i g h t 9
¾
l b s .
T e m p e r a t u r e o f
t h e r o o m 2 3 C e n t .
I n t o c h l o r o f o r m b o x a t 7 h
.
4 9 m .
1 0 s .
F a l l e n
d o w n
a t
7 h .
5 2 m . 1 0 s .
P l a c e d o n
t h e
b o a r d a t 7 h . 5 3 m . a n d k e p t q u i e t w i t h
c h l o r o f o r m . L
e f t c a r o t i d e x p o s e d a n d
a
l o o
p p l a c e d u n d e r t h e r i g h t
v a g u s . O p e r a t i o n
t o e x p o s e t h e
s p l a n c h n i c s
c o m - m e n c e d a t 8 h . 1 1 m . 3 0 s . L e f t
s p l a n c h n i c l i g a t u r e d
a t
8 h .
18m. and the plexus
excised. Artery ligatured at 8h. 24m. 5s. Canula inserted at 8h. 29m. 10s.
Temperature in rectum 97 F. Connection with manometer at 8h. 37m. 40s.
One Ludwig and one Fick tracing.
O b s e r v a t i o n s
.
A .
8 3 8
4 5 . — A d m i n i
s t r a t i o n
o f
c h l o r o f o r m ;
struggling.
B . 8 4 4 0 . — A d m i n i
s t r a t i o n
of ether on a cap
.
vagus.
tracings. At 9h. 5m. the experiment was brought to an end by the canula cutting
through the artery, a n d e v e n t u a l l y t h e a n i m a l w a s k i l l e d w i t h c h l o r o f o r m .
93
(After the manometer experiment was closed the convolutions of the brain
were exposed, but stimulation failed to give any result.)
November 23rd.—No.
113.
Monkey, weight 12½ lbs., given two grains of morphine under the skin of
the thigh at 10h. 1m. Tied on to the dog-board at 10h. 19m. and two grains
more morphine injected at 10h. 20m. 10s. Quite wide awake at 10h. 30m.
10s. Given a little chloroform at 10h. 35m. 30s., when he was slightly under the
influence of morphine and kept quiet with chloroform. Loop under both vagi.
Right pupil slightly dilated. Left contracted at 10h. 48m. Artery ligature
d at 10h. 50m. 45s. Canula inserted at 10h. 53m. 15s. Right pupil then
widely dilated . Temperature 100·6 F. Connection with manometer at 11h. 8m.
Two Ludwig and two Fick tracings.
Obse rvations.
H. M .
S.
A. 11 12 30. —Ordinary chloroform administration.
B. 11 17 0. —Li gat ur e of t he f emor al ar t er y and
veine.
C. 11 29 25. —Hæmorrhage f r om f emoral
artery.
D.11 31 10. —Tr a ns f us i o n of s al i ne sol ut i on a n d a mmo n i a ( 5
mi ni ms l i quor ammo n i æf or t . t o 25 ounces of s al i ne) . Res-
pi rat i on st opped at 12h. 11m. 30s., but after con-
t i nuous art i fi ci al respi rat i on t he ani mal gave
one gas p at 12h. 22m. 30s . and began breathing natu-
ral l y at 12h. 23m. 30s. Dur i ng al most t he whol e
of t hi s t i me t he manomet er t raci ng wa s interrupted
by clots in the tubes.
E. 11 55 0. —Et her inhalation at short intervals
.
F. 12 14 30.—Needle into the
heart.
G. 1 2 3 0 3 5 . —Sma l l i nc i s i o n i nt o abdomen and injection of spirits
of ammonia into the stomach
.
H. 12 35 48.—Pushing e t h e r
.
I. 12 37 0. —Pushi ng chl orof orm until death.
( Thema n o me t e r t r a c i n g wa s a g a i n i n t e r r u p t e d be f or et h e e n d o f the
experiment.)
November 25th.—
No. 117
Te mpe r a t ur e o f t h e r o o m 2 3 Ce n t . Unus ua l l yl a r ge br i ndl e d dog.
Weight 38¾ lbs. Into the chloroform box at 7h. 28m. 10s. Placed on the
94
table at 7h. 36m. 20s., and kept quiet with chloroform. Left carotid
l i g a t u r e d a t
7 h .
4 6 m .
1 0 s . C a n u l a
inserted at 7h. 49m. 15s. Temperature in rectum
101·4 F. Connection made wi th the manometers at 7h. 56m. 15s. Four
Ludwig and six Fick tracings showing the effect of pushing chloroform during
irritation of the entire right vagus on several occasions. In one of these the
irritation of the vagus was kept up continuously for more than eight minutes,
and the chloroform administration for seven minutes and the animal recovered
without artificial respiration. At another time when the irritation accidentall
y f a i l e d
o n
a c c o u n t
of defect in the electrodes, the animal was with difficulty re-
stored after chloroform had been pushed for one minute. Death event
u a l l y
e n s u e d a f t e r p r o l o n g e d i r r i t a t i o n o f t h ev
a g u s
together with pushing chloroform
and artificial respiration to ensure the chloroform entering the lungs freely.
Observations.
H. M . S
A. 7 56 0.—Chloroform on an ordinary ca
p
B. 8 1 40.—Electrical irritation of the right vagus. Inhibition of
the heart is seen in Fick 4.
C. 8 2 50.— Chloroform pushed to stoppage of respiration ; artificial
respiration ; irritation of right vagus during revival
(vide Fick 5)
.
D. 8 9 10.—Irritationo f r i g h t
v a g u s ,
chloroform commenced at
8h. 9m. 20s. and pushed to stoppage of respiration
(8h. 10m. 25s). chloroforms t o p p e d
a t 8 h . 1 1 m .
50s.
;
irritation of the vagus stopped at 8h. 12m. 10s.
Natural breathing at once recommenced spontane-
ously. Observation repeated in the same way and
with the same result at 8h. 15m. 30s. (vide Fick
6.) Observation repeated for a much longer time at
8h. 28m. 30s The chloroform and irritation of t
he
vagus were kept up from 8h. 28m. 30s. to 8h. 36m.
40s. (vide Fick 9, 10, 11, 12, 13 and 14). Direc
tly
the irritation was stopped the pressure rose, showing
that very little chloroform had hitherto been con-
veyed to the nerve centres, and that there is no
danger in mere lowering of the blood-pressure. The
pressure fell again at 8h. 37m. 0s. This evidently
occurred from the inhibition of the heart having been
95
H . M .
S .
stopped. The residual chloroform in the lungs was
t h e n r a p i d l y t a k e n u p a n d p r o d u c e d i t s o r d i n a r y
effect. (Compare with Observation D in Experi-
ment 64)
E .
8 52 30.—Chloroform administration for one minute and
twenty-five seconds. R espiration stopped at 8h.
53m. 55s. Artificial respiration was then perform
ed for two and-a-half minutes, from 8h. 54m. 0s., and
natural breathing recommenced at 8h. 57m. 0s.
F . 9 2 2 0 . — E l e c t r i c a l i r r i t a t i o n o fv
a g u s ;
the stimulation was
effective at first (vide Fick 19). but wore off and
when chloroform was administered at 9h. 3m. 0s.
it had almost ceased, and the full effects of the
anæ sthetic were quickly developed. Respiration
stopped at 9h. 4m. 0s. and the chloroform cap was
removed at 9h. 4m. 15s. Though the anæ sthetic
had only been administered for little over a minute,
the animal was restored with great difficulty
by
artificial respiration, which was kept up for six
minutes and thirty-five seconds before natural
b r e a t h i n g r e t u r n e d a t 9 h . 1 1 m .
0 s .
G . 9 1 9 2 0 . — C h l o r o f o r m p u s h e d a g a i n w i t h i r r i t a t i o n o f t h ev
a g u s
at
the same time. In this observation the stimulation
did not become effective till after the respiration
stopped. The breathing ceased at 9h. 20m. 20s.
The irritation was stopped at 9h. 21m. 25s. and
the chloroform cap was removed at 9h. 21m. 35s.
Breathing recommenced spontaneously at 9h. 23m.
50s., but was not fully established till 9h. 25m 15s.
During this time there were some remarkable fluc-
tuations of the blood-pressure, the falls being pro-
bably due to residual chloroform being taken up
from the lungs, alternating with rises due to elimi-
nation of the anæ sthetic from the lungs when the
animal breathed (vide Ludwig III. at 9h. 22m. 0s.,
9h. 24m. 0s . a nd 9h. 25m. 0s . )