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tion had taken very well indeed in 24. Here and there an insertion or two had failed,
but for all that, the protection of the system was, in my opinion sufficient. It often
happened, also, that the failure was not a complete one. Out of some 10 or 12 or
more children vaccinated, perhaps in one or two a vesicle or two only would show
themselves—but these of the true Jennerian type, containing lymph if possible more
effective and energetic than any cow-pox lymph, the smallest possible quantity sufficing
to produce a vesicle and not a single puncture proving a failure, thus showing that
the original cow-lymph which produced the particular vesicle was not inert. There
was a very curious instance of this, that came within my observation. On the 17th
December last, I inoculated a small heifer, with fresh fifth-day lymph. On the fifth
day after the operation, vesicles had risen, and though rather diminutive were appa-
rently good. 9 children were vaccinated on this day. On the following day the remain-
ing vesicles had somewhat dried up ; but with two comparatively fresh ones two more
children were vaccinated. All the first failed. The second day's two children, I
saw on the 6th day after the operation. In one the operation had completely failed,
in the other there was a miliary little red papule on the site of one of the punctures. Of
course, I took this for a failure also. I vaccinated both these children again on that
very day, and on the 3rd day after,when I went to observe the progress of the operations,
to my perfect astonishment I saw the little papule blown into a fine well developed,
genuine-looking vesicle. This was indeed the 8th day of the 1st operation, and the
vesicle had the appearance of an ordinary developed 6th day vesicle. The secondary
vaccination was also successful, three vesicles had formed from the new punctures.
They followed suit with the first one. They had formed earlier, had remained diminu-
tive all through their course, which was perfectly regular. Many heifers proved complete
failures, and these were invariably from those that were supplied to us by the Munici-
pality. Private heifers were all more or less successful with only one exception ; as
private heifers became scarce, our sources of good lymph began to be exhausted ; and
at length our failures became so very continuous, that in August we had to stop animal
vaccination altogether for a time. During the month of September, having secured a
few private heifers, and having bought some at Bandora I again commenced operations
with lymph received from Dr. Blanc, and some I had myself preserved, and succeeded
once more in establishing animal vaccination. The private heifers with a clean, clear,
and thin skin, and always thoroughly healthy, were our salvation, as those supplied by
the Municipality were our bane. Why this was so, I have not to this day been able to
ascertain. Our operations went on pretty satisfactorily with more or less of success,
till in the last week of November, owing to want of good heifers, our lymph again
degenerated, and we had again failure after failure in heifers. This state of things
continued till the middle of December, when a heifer inoculated on the 11th of that
month, with some preserved lymph, proved successful, and gave us a fresh start once
more. Since that time our animal lymph has been in an excellent and effective con-
dition, twice replenished and renewed as it has been with lymph received from
Dr. Warlomont of Brussels. Up to the end of the year our success has been wonder-