ABSTRACTS
Jacotot, H. (1947). Etude du vaccine contre la peste bovine. Rev. d Immun. Ther. Antimicrob.
11, 4-5, 222-275 [English summary]
(Author's conclusions)
T HE normal saline wash of minced tissue constitutes a poor vaccine in general. Its effi-
cacy is proportionate with the quantity of antigen extracted by the processes of mincing
and washing by gathering this small quantity of antigen one does not obtain an increase of vaccinat-
ing substance.
Formalinized dried vaccine is superior to formalinized liquid vaccine even when the latter is
freshly prepared ; the first vaccine best conserves its potency at 25-30°C. and the latter at 6°C.
Formalinized dried vaccine maintained at laboratory temperature is somewhat inferior to toluene
vaccine maintained under the same conditions.
The immunity conferred by the dry vaccine is almost of the same duration as the immunity
conferred by toluene vaccine but the results of vaccination are probably more uniform with the
former ; dry formalinized vaccine gives a more lasting immunity than the ordinary liquid formali-
nized vaccine.
In the same conditions of concentration of the virus, whether it be in the form of a powder or
a saline extract, the dry vaccine has a much smaller volume; this is an advantage which favours
its use in certain circumstances. However, such circumstances are not always encountered in prac-
tice ; particularly in Indo-China vaccination in the field has to be carried out by subordinate staff
to whom the vaccine is sent from the nearest veterinary field dispensary. There is an additional
disadvantage in that the dry vaccine forms clumps when water is added to the powder and this
not only makes vaccination difficult but also the assessment of the actual quantity of the vaccine
inoculated. This is the reason for our present opinion that a formalinized adsorbed alumgel vaccine
is much to be preferred in field practice. [J. F. S.]
Jacotot, H. (1947). Etude du vaccine contre la peste bozine (2nd memoire). Les techniques
vaccination. Rev. d'Immun. Ther. Antimicrob. 11, 6, 329-381.
(Author's summary and conclusions)
T HERE is no reason to doubt or even question the conclusion that rinderpest vaccines pre-
pared from formalinized emulsions of the tissues of a bovine experimentally or
otherwise injected with the virus of rinderpest contains living virus ; such vaccines nevertheless pos-
sess strong and uniform immunizing properties. Other things being equal, such as the methods of
preparation of the vaccines and the actual concentration of tissues in the emulsion, vaccine prepared
from lymph gland tissue is approximately twice as potent as that prepared from spleen pulp and at
least four times as active antigenically as that made from lung pulp. Even the intestinal mucosa
may be used in vaccine preparation, the necrotic portion especially having a higher antigenic value
than spleen pulp.
The small pox lymph obtained from she buffaloes or heifers inoculated both
with rinderpest virus and lymph vaccine possesses an antigenic value almost comparable with fresh
rinderpest virus and of greater potency that spleen pulp. Liver and testicular tissues are antigeni-
cally inactive or at the best have but feeble immunizing value and are valueless in the prepa-
ration of rinderpest vaccine.
The antigenic value of the selected tissues of calves artificially infected with virus is nil during
the period of inoculation ; it is evident, though very feeble, at the first day of fever and reaches its
maximum with the maximum temperature reaction, or very shortly after ; it remains at this level
for two or three days then diminishes until at about the tenth day it is hardly demonstrable.
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