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Summary showing the number and ratios of the corpuscular constituents of the blood of Surra horses
subjected to treatment with arsenic and iron together with the days of disease and treatment and the amount
of the drugs administered, when a cure was effected and when death followed respectively.
(i) Table of corpuscular elements in health—horse, mule, donkey.
(ii) During treatment of Surra.
Summary of the number and ratios of the corpuscular constituents of the blood of Guinea pigs before and
after inoculation with Surra blood, together with a table showing the results when the paroxysms and intermis-
sions are massed together.
Table showing the number of hæmatozoa red and white corpuscles in each cubic millimetre of blood of rats
and bandicoots together with the animals body weight and that of the principal organs.
(i) Rats (mus decumanus).
(ii) Bandicoots [mus (nesokia) giganteus].
Remarks—
On the changes observed with regard to the number of red, white and coarsely granular oxyphile cells
(Eosineophile cells) in the blood of animals.
(i) When Surra has been acquired naturally or by experimental inoculation.
(ii) After successful inoculation with the rat hæmatozoon.
(iii) During the period of treatment of Surra with arsenic.
Further remarks on the etiology of Surra. Hippuric acid Table.
453. These observations, which represent an enormous amount of detail and
work, are of exceedingly great interest and value to scientists, but would not,
as a rule, be understood by the readers of this report.
The detailed report submitted by Dr. Lingard will, therefore, be printed
separately.
The following "summary of the changes in the blood" and " further
remarks on the etiology of Surra," being of interest, are here inserted.
"SUMMARY OF THE CHANGES IN THE BLOOD."
The changes observed with regard to the numbers of red, white and coarsely granular exyphile cells
(eosineophile cells) in the blood of animals.
(i) When Surra has been acquired naturally or by experimental inoculation.
(ii) After unsuccessful inoculation with the rat hæmatozoon.
(iii) During the period of treatment of Surra with arsenic are detailed as follows :—
RED CORPUSCLES.
(i) When Surra was acquired naturally or by inoculation.—An increase in the number of red cor-
puscles occurred in the latent period equal to 9.7 per cent. in the horse and 5 and 1.87 respectively
in the mules. During the paroxysms there was a decrease, most marked in the case of the mules.
A further decrease occurred in the intermissions except in the case of mule II.
TABLE I.
Showing the percentages of red corpuscles taken on the mean daily number found in the blood of the horse
and mule, during different periods of health and disease.
Periods.
Health ... ... ... ... ...
Latent period
...
... ... ...
Paroxysms ...
... ... ... ...
Intermissions
... ... ... ...
Whole period
...
...
...
...
Horse No. 89.
Per cent.
100.00
109.70
86.01
74.98
87.16
Mule I.
Per cent.
100.00
105.00
61.34
52.35
68.67
Mule II.
Per cent.
100.00
101.87
65.17
67.17
79.14
(ii) After unsuccessful inoculation with the rat hœmatozoon.—Taking the mean of five inoculations
(donkey), the effect produced 24 hours after inoculation, was to increase the number of red corpus-
cles 10.48 per cent., whilst at the end of 72 hours a reduction in their numbers equal to 11.79
per cent. had taken place.
(iii) Treatment of Surra with arsenic.—In horses, after an interval of several days, from 9th to 12th
day of treatment, a considerable increase in the number of red corpuscles took place, in some
cases approaching 70 to 100 per cent. This rise was followed by a fairly gradual decrease, which
in a mean of 8 cases was found to commence on the 41st day of treatment, after 403.4 grains of
arsenic had been administered. A secondary increase in the numbers recorded, occurred just before
death in 5 out of 8 cases.
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