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appearing almost somnolent, head hanging, eyes dull and heavy, and the attitude indicative
of extreme depression, and œdematous swellings present around the lips and lower part of the
nose. The surface of the body was cold, especially at the extremities, the internal tempera-
ture and the pulse were subnormal. Stimulants were administered, chiefly Ammonia, and
friction carried out over the body and limbs with a view to exciting the circulation. In the
evening the temperature and the pulse had slightly risen. The Alkaloids and Arsenic were
discontinued. After this date, on account of the animal's state, it was found impossible to
continue the experiment.
Biniodide of Mercury.―The double Iodide of Mercury and Potassium.
This salt is said to have given great satisfaction as an antiseptic germicide for
surgical purposes, a 1 in 4000 solution is equal in activity to a 1 in 1,200 solu
tion of corrosive sublimate, over which it has the very important advantage of
being markedly less poisonous.
Iodic: Hydrarg.
Case No.. LXXIII.—This animal, an Australian Gelding, aged seven years, belonging
to the Bombay Tramway Company, developed fever on the
14 th October 1892, after having been in the country exactly
six months. The hæmatozoon was discovered on the 30th October. The animal arrived
at the Laboratory Hospital on the 31st October, the 2nd day of the disease, and it was
deemed advisable to commence treatment at once, as the loss in condition was well marked,
and the disease appeared to be progressing. In this case it was decided to try the effect of
Iodic : Hydrarg : (the soluble Double Iodide of Mercury and Potassium) which is said to
possess the following advantages over Mercuric Perchloride, viz., that the bacteriocidal
power of a solution of 1 in 4,000 is equal in activity to a 1 in 1,200 solution of HgCl 2
and that it is markedly less poisonous. The salt is also said not to possess the power of
precipitating albumen. Consequently on the evening of the 31st October, the hæmatozoon
being absent from the blood and the temperature 38.3°C, two grains were administered in
half a pint of water; as the temperature remained low, and the organism still absent from
the blood, on the following morning a similar dose to the former was given, followed by
three grains in the evening. On the morning of the 2nd of November, the hæmatozoon was
again observed in the blood, and three grains were administered with a temperature of
38.l°C.,butby the evening the thermometer registered 39.8°C., and attained a maximum on
the evening of the 4th, when it registered 40.5°C. During these two days the hæmatozoa
were respectively few and numerous in the blood, and nine grains of the drug were given
on the former, and twelve on the latter day. On the morning of the 5th the temperature
had fallen two points below that of the previous evening, and by midday registered 40°C.
The hæmatozoon was absent from the blood, and eleven grains were given during the day.
On the morning of the 6th the temperature was 37°C., having dropped 3°0. since noon on
the 5th, but again rose to 38.7°C. by 5
P.M. same evening. From this date until the
evening of the 12th there was continued fever, the highest temperature recorded being
40.5°C., but the hæmatozoon continued to be absent from the blood, this being the eighth
day in succession. During this period seventy grains of the drug were administered, made
up of four doses of four grains, and nine doses of six grains. On the morning of the 13th
the temperature had fallen to 38.4°C, and during this and the following day it remained
low, and the hæmatozoon was absent from the blood ; the animal in the meanwhile received
eighteen grains of Iodic-Hydrarg. On the 15th the hæmatozoon re-appeared in the blood,
and the temperature, which at 8 A.M. registered 38.2°C., began to rise, but did not reach a
maximum until the evening of the 16th, when it was 4l.7°C. As up to this time 154 grains
had been administered, without any apparent effect on keeping down the temperature, or,
reducing the number of hæmatozoa, which at this time were numerous in the blood, Quinæ
Sulph, three drachms, were administered, On the morning of the 17th the thermometer
registered 39°C., a fall of 2.7°C. in the night, and the organism was found absent from the
blood. From this date until the evening of the 21st the temperature fell, and remained
more or less within the normal limit ; at the same time the hæmatozoon was absent from
the blood. Nine drachms of Quinine and 55 grains of Iodic. Hydrarg. were administered.
By the evening of the 22nd the thermometer registered 40.8°C. The hæmatozoa had
again appeared and were numerous in the general circulation, and as up to 9 A.M. on this
date 214" grains of Iodic. Hydrarg. had been given since the 31st October, without
producing any marked effect on the hæmatozoon, and none at all on the temperature, it
was deemed advisable to substitute Arsenic for this drug ; at the same time it was fully
recognized that the disease having now been present for 24 days, the death of the animal
was almost certain, and was simply a matter of time. At 6 P.M. the animal received Liq :
Arsenicalis 3x, equivalent to gr. v, and by the following morning the temperature had
fallen to 39.5°C. The dose was increased on the evening of the 23rd to gr. vi, and
remained at that until the evening of the 25th, when owing to the temperature registering
40°C, and the organism still being numerous in the blood, the dose of Arsenic was again
increased to gr. vii. On the morning of the 26th the temperature was 38.7°C., P. 60, R. 12 ;
the hæmatozoon was absent from the blood, and the animal brighter in appearance. The
temperature registered 38°C. on the morning of the 27th, P. 48, R. 12, From this date
until February 17 th, 1893, on which the animal died, the treatment was continued, and the
hæmatozoon remained absent from the blood.
B 1086—29