clxiv
1st February.—Condition unchanged. Temp. A.M. 39.4°C. P. 69. R. 16. The
hæmatozoa are few in the blood. Temp. 1 P.M. 40°C. Urine, turbid, viscid, muddy-
yellow coloured. Sp. Gr. 1,031. Faintly alkaline, no albumen, no crystals of Carbonate.
and only a trace of effervescence on the addition of Acetic Acid. Temp. 5 P.M. 40°C.
2nd.—The animal appears dull and sleepy, hangs its head, but brightens up occa-
sionally to feed and then again relapses.
Temp. A.M. 39.8°C. P. 66. R. 14. The
hæmatozoa are numerous in the blood. Temp. 1 P.M. 40.1°C. Urine, not so turbid or viscid,
orange in colour. Sp. Gr. 1,037. Faintly acid, no albumen. Temp. 5 P.M. 40.1°C.
3rd.—The animal is decidedly weaker, the swelling and oedema is spreading between
the fore-limbs, but the appetite remains good. Temp. A.M. 40°C. P. 80. R. 18. The
hæmatozoa are swarming in the blood. Temp. 1 P.M. 40.1°C. Urine, clear, viscidity has
disppeared, of a reddish-yellow colour. Sp. Gr. 1,026. Acid, no albumen, absence of
Carbonates. Temp. 5 P.M. 40.3°C.
4th.—The condition of the animal is unchanged. Temp. A.M. 38.6ºC. P. 75.
R. 24.
The hæmatozoa are swarming in the blood. Temp. 1 P.M. 39.6°C, Urine, clear,
strongly acid, orange in colour. Sp. Gr. 1,022. No albumen, absence of Carbonates. Temp.
5 P.M. 40°C.
5th.—The animal is very much weaker and the œdema has extended on to the chest.
Temp. A.M. 39.8°C. P. 64. R. 22.
The hæmatozoa are swarming in the blood. Temp. 1 P.M. 40.3°C, Urine clear,
absence of viscidity. Sp. Gr. 1,018. Strongly acid, no albumen, absence of Carbonates.
Temp. 5 P.M. 39.4°C.
6th.—The animal is much weaker and has assumed the recumbent position. Temp,
A.M. 39.4°C. P. 68. R. 26.
At 10 A.M. after a short period of struggling death took place,
AUTOPSY held at 12-30 P.M. Body somewhat emaciated, there is considerable œdema
of the extremities and of the under-surface of the abdomen, No fluid in the pleural
cavities.
Lungs.—Dotted over with a few sub-pleural blood extravasations not invading the tissues
to any extent. On section the lung tissue is stained somewhat yellow in colour with a
bright-red flush.
Heart.—Weighs 4 lbs. 15 ozs. Many extravasations externally, especially down the
course of the coronary vessels—yellow jelly-like exudation round the base and running to
a smaller extent along the course of the vessels. No pathological changes observed in any
of the cavities of the organ with the exception of the left ventricle. Here an extravasation
about 3/4th inch in length and half an inch in width is situated on one of the musculi-papil-
lares lying under the endocardial lining.
Spleen.—2 lbs. 8½ ozs., firm in texture, covered on the convex surface with small extra-
vasations of blood.
Liver.—Weighs 13 lbs. 11 ozs. The external appearance is normal and on section
healthy.
Kidneys.—No extravasations under the capsule. Right weighs 1 lb. 7 ozs.; left 1 lb.
8 ozs.
The Intestines present nothing pathological externally, but on examination of the
internal surface many extravasations present themselves to view. The greater number are
small in size, round and dotted over the whole length of the mucous membranes of the
small intestines. Here and there patches of congestion are found, from one to two inches
in length and about half that width, but there is no ulceration. No parasites.
The points of interest in this case are :—
(i). That the disease was successfully transmitted by the subcutaneous injection of
0.1c.c. of blood containing swarms of hæmatozoa at the time of inoculation.
(ii). That the period which elapsed between the subcutaneous introduction of the
blood and the first appearance of the hæmatozoon in the general circulation was only
four days, and yet, fluid extracted with the aid of a Pravaz syringe from the raised
tumor at the seat of inoculation on the day previously, revealed the presence of the
hæmatozoon in it.
(iii). The time which elapsed between the inoculation and the death of the animal
was forty-two days.
(iv). The very slight pathological lesions found at the Post-mortem examination.
(v). The complete absence of parasites from the intestines.