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Jugular Vein, but up to the 14th November their blood which had been examined
daily failed to show any signs of the Surra hæmatozoon.
No. I. Guinea-pig.—Subcutaneously inoculated on 17th June 1891 with 0.2c.c
of blood taken from the bull, eighty-five days after the latter's inoculation from
the horse. The latent period occupied ten days. The temperature rose over a
degree and a half on the evening of inoculation and remained between 40°C. and
40.6°C. until the evening of the fifth day, when it fell to 38.4°C. From the
first the fever assumed the continued type accompanied by remissions and exacer-
bations and by irregular intermissions at short intervals, during the first few
weeks, but became far less frequent during the latter half of the time during
which the animal lived. Death occurred on the 8th November, the 135th day
of the disease.
Autopsy.—Body emaciated. Lungs the seat of a localized emphysema,
posterior two-thirds of anterior lobes of the right lung consolidated. Spleen
enlarged five times normal size. The other organs presented a healthy appearance.
No. II. Guinea-pig.—The fellow of No. I inoculated in an exactly similar
way to the former ; presented a latent period of eighteen days. The temperature
curve for the first five days after inoculation was almost a facsimile of that pre-
sented by No. I Guinea-pig. From the first the fever assumed the continued type
accompanied by daily remissions and exacerbations, and by intermissions occur-
ring at short intervals during the first few weeks, but becoming much less
frequent as the case advanced. Death occurred on the 12th October, the 100th
day of the disease.
Autopsy.— Body emaciated. Pleural cavities filled with pus. Emphysema—
Anterior half of the anterior lobe of both lungs consolidated. Spleen enlarged
to three times normal size. The other organs presented a healthy appearance.
No. III Guinea-pig.—Subcutaneously inoculated on the 3rd September 1891,
with 0.2 c.c. of blood taken from the bull one hundred and sixty-three days after
the inoculation of the latter from the horse. The latent period occupied nine
days. The fever was of the continued type accompanied by almost daily remissions
and exacerbations and by intermissions at frequent intervals. Death occurred
on the 24th October, the 43rd day of the disease.
Autopsy.—Body emaciated. Lungs, localized emphysema at the apices,
oedema of the posterior lobes. Liver enlarged, old perihepatitis. Spleen enlarged
to three times its natural size. Stomach healthy. Kidneys ditto.
No. IV Guinea-pig.—the fellow to No. III. Subjected to exactly the same
conditions as those described under the former. The fever was of the continued
type, accompanied by daily remissions and exacerbations, and by frequent inter-
missions. Death occurred on the 14th December, the 94th day of the disease.
Autopsy.—Body emaciated. Lungs.—The apices, the seat of a localized
emphysema. Spleen enlarged. Liver and Kidneys, apparently healthy.
Sheep No.. I.—A young country-bred ram, was inoculated subcutaneously
with 0.8c.c. of blood containing a few hæmatozoa taken from the Jugular Vein of
Horse No. VII. The hæmatozoon being still absent from the blood fourteen.
days later, the animal was reinoculated with l.0c.c. of blood containing a few or-
ganisms from the Jugular Vein of Horse No. VI. On the twenty-eghth day after
the re-inoculation, fluid was observed to be present in the right tunica vaginalis
testis and on the forty-fifth day, there was in addition a discharge of muco-
purulent material from the right nostril. The hæmatozoon was absent from the
nasal fluid, but present in that drawn from the tunica vaginalis on the same date.
It continued to be absent, however, from the blood. On the 104th day after the
re-inoculation, the animal presented symptoms of loss of power on the left side of
the body, involving both fore and hind limbs, but it could walk for a short dis-
tance without falling.
On the eighteenth day after re-inoculation, as the hæmatozoon had not been
discovered in the blood, it was decided to inoculate two Guinea-pigs with blood
from the animal, in order to prove whether the organism existed in any form in
the general circulation. This accordingly was done and each animal received
subcutaneously 0.7c.c. of blood drawn from the ear of the sheep. In the case of