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try the effect of Liq. Potassæ in large doses on the hæmatozoon, and as the temperature rose
the same evening to 40°C., a dose of 3iv was administered. On the morning of the
27th the temperature was 39.1°C., P. 76, R. 20, and the hæmatozoon absent from the
blood, but by evening the temperature had again risen to 39.7°C., P. 80, R. 34 ; nine
drachms of Liq. Potassæ were given during the twenty-four hours. By the 28th,
temperature, pulse and respirations had all fallen considerably, but the organism had
again made its appearance in the blood. The urine was found to contain in addition to
albumen 1/22nd, and casts, a trace of bile and bile acids. At five P.M. the Temp. was
40.2°C., P. 72, R. 24. Three doses of medicine were administered during the day. On
the morning of the 29th, the animal presented a dull appearance, and there was a slight
mucous discharge from the nostrils ; the temperature had fallen a degree during the night,
but the pulse was dicrotic, and registered the same as on the previous evening, and the
hæmatozoa were few in the blood. Three doses of the medicine were repeated. On the
30th, the animal again presented a dull appearance ; the visible mucous membranes were
clean, but the conjunctivas peteohiated; there was also considerable oedema of the extremities
especially of the hind limbs, and the sheath presented the same condition, but to a more
limited extent. Temp. A.M. 39.3°C., P. 72, R. 20. Hæmatozoa few in the blood. Three
doses of medicine were repeated. December 1st.—The animal looked brighter, but the disease
continued to progress ; the visible mucous membranes were tinged yellow, and the left
conjunctiva invaded by five large petechiæ. The pulse was regular, but the beat forcible,
and jugular regurgitation was present. The hæmatozoon, however, was still present in the
blood, and the œdema of the sheath and extremities had increased in amount. Owing to
the presence of a denuded patch on the floor of the mouth, from which the mucous mem
brane had been accidentally removed whilst administering the medicine, it was decided to
omit any further doses of Liq. Potassæ until the abrasion had healed. Up to this time, the
animal had received sixty-three drachms of Liq. Potassæ in thirteen doses equivalent to about
220 grains of Hydrate of Potassium. The disease had continued to progress during the admi
nistration of this chemical, but it had in no way disarranged the organs of digestion, for the
appetite was noted on this date as excellent. On the other hand, the albumen in the urine
had steadily increased in amount during its exhibition, but it is difficult to say to what
extent, if any, the increase of albumen was due to the large doses of Potash.
On December 2nd, the temperature was 39.4°C., P. 72, R. 20, the hæmatozoa had
increased, and were now numerous in the blood, but the general condition of the animal
was unchanged. On the morning of the 3rd, the temperature maintained the degree regis
tered on the previous evening, pulse 68, but the respirations had fallen to 16 per minute
and the organisms were still numerous in the blood. The pulse beat was forcible and quick
but regular. The œdema of the under-surface of the abdomen had extended forward, and
the albumen in the urine had attained to ⅓ rd ; in addition there were numerous blood and
epithelial casts, and a few pus cells. On experimentation the re-action for bile pigment was
well marked. In consequence of the unsatisfactory condition presented by the animal, it
was decided not to recommence the administration of the Liq. Potassæ, but to substitute
Arsenic for it, commencing with the full physiological dose of four grains, to be repeated
once in the twenty-four hours.
Arsenic.
On the evening of the 3rd December, Temp. being 39.4°C., P. 72, R. 20 , the first dose
of grains iv, was given after the evening meal in the drinking
water in the form of Liquor Arsenicalis. On the following
morning the temperature was 39.2°C., the pulse remained as before, but the respirations
had increased to 24 per minute. The hæmatozoa were few in the blood. The same dose
of Arsenic was continued, making eight grains in all. On the morning of the 5th
the temperature had fallen to 38.2°C., the pulse to 64, Respirations 20, but the animal
presented a dull appearance, and the general symptoms of the disease were intensified,
but still the appetite remained excellent. There were a few hæmatozoa in the blood.
At 5 P.M. the same evening the pulse had again increased in frequency, and registered 76
per minute. Temp. 39°0. R. 24. Ten grains of Arsenic were given during the day. On the
morning of the 6th, the temperature had fallen half a degree, P. 64, R. 12., but the hæma-
tozoa were very numerous in the blood. The same dose of Arsenic was continued. By the
following morning the temperature had again fallen a degree, but the organism was still
present in the blood, although in small numbers. The animal continued to present a dull
and semi-somnolent appearance, and the œdema had increased in amount between the fore
legs. In the evening the thermometer registered two-thirds of a degree above the morning
observation. Arsenic increased to grains vi, bis die. During the following night the tem
perature fell, and at 8 A.M. registered 37°C. in the rectum ; the pulse was 60, R. 12. There
were a few hæmatozoa in the blood, but the appearance of the animal was brighter, and the
œdema on the under-surface of the abdomen was slightly reduced in amount. The tempe
rature, however, again rose in the evening, a little over a degree, and registered 38°C. on the
morning of the 9th, the pulse being 60, and respirations 12, but the hæmatozoon was absent
from the blood. It will, thus be observed on reference to the Chart, that five days and a half
had elapsed since the commencement of the Arsenical treatment, and during that period
fifty-six grains had been given in the drinking water. For the next two days the dose was
increased to fourteen grains per diem, in order to try and effect the destruction of any
miniature forms of the organism, which might be present in the blood. The temperature on.