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followed by a third dose of minims xx on the 15th June. The blood remained
normal and no symptoms supervened until the early part of October,
when the animal made a noise resembling the cry of a hydrocephalic child.
At a later date the animal vomited and fell with a cry becoming unconscious for
some minutes ; these attacks became more frequent and death occurred on the
11th of November 1891.
Autopsy.—Thoracic and abdominal organs appeared healthy. On opening
the cranium, the animal was found to be the subject of Hydatido-cephalus
or " Gid," due to the presence of the " Cœnurus cerebralis."
Goat No. III.—Two years of age. Subcutaneously inoculated on 4th June
1891, with 1.0 c.c. of blood which contained the hæmatozoa (swarming) taken
from the heart of Horse No. XXI. five and a quarter hours post mortem. The
latent period occupied six days.
The fever was of the continued type, accompanied with daily remissions and
exacerbations, from the ninth clay to the one hundred and fifty-second day of the
disease, and was marked by intermissions on the 12th, 32nd, 46th, 49th, and 134th
days of the disease. The hæmatozoon was present off and on in the blood for
fifteen days, after this it was absent for twenty-six days. From this time until
death the organism was always absent from the blood, but excepting the last
10 days was present in the fluid drawn from the tunica vaginalis.
Autopsy.—Body emaciated. Liver perihepatitis. Stomach, healthy. Kidneys
ditto. Spleen attached to stomach by firm bands of organised lymph. Testicles
hard, and cord thickened. Brain, convolutions flattened, lateral ventricles dilated
with colourless fluid.
RABBITS.
Two adult animals were subcutaneously inoculated on November 2nd, 1890,
with 0.3 c.c. of blood which contained very numerous hæmatozoa taken from
Horse No. II.
No. 1.—The latent period occupied five days. Continued fever was present
with remissions but only one intermission on the 29th day of the disease, from
the clay previous to the appearance of hæmatozoa in the blood until death.
Autopsy.—Body emaciated, the integument surrounding eyes, nose and
mouth swollen and the seat of solid oedema. Yellow-creamy pus exuding from
the nostrils and eyes. Lungs the seat of localized patches of emphysema. Heart
presented a healthy appearance. Stomach mucous membrane thickened, otherwise
normal. Other organs healthy.
No. II.—The latent period occupied nine days. Continued fever with daily
remissions and exacerbations was present from the sixth day after inoculation to
the 31st clay of disease, on which day there was an intermission followed by a
second intermission on the 35tb, lasting 48 hours ; death followed on the 37th
day of the disease, 21st December 1890.
Autopsy.—Body emaciated, localized emphysema of the lungs. The other
organs presented a healthy appearance.
GUINEA-PIGS.
Two were subcutaneously inoculated on 2nd November 1890 ; each received
1.0 c.c. of blood containing very numerous hæmatozoa taken from Horse No. II
ante mortem.
No. I.—The latent period occupied eleven days. There was continued fever
with remissions during a period of forty-one days, from the fourth day of the
disease until death, whilst slight intermissions occurred at irregular intervals.
Death occurred on the 27th December, the 45th day of the disease.
Autopsy.—Body fairly well nourished. Lungs presented circumscribed
patches of emphysema, and several sub-pleural petechias. Liver, enlarged, gall
bladder distended with a clear fluid. Spleen, enlarged, weighed seven grammes.
Stomach contained some grumous blood and slight ulceration near the pyloric
end of the organ.