cxxxiii
over the visceral pleuræ, small gritty excrescences are to be felt over the entire area of both
organs. These excrescences vary in size from a mustard seed to a small pin's head, and pre-
sent an appearance not unlike that presented by grey miliary tubercles. There are also
numerous larger bodies which lie in the substance of the tissues 1/4 th to 3/4 th of an inch below the
visceral pleurae, feel very hard and when cut down upon are found to be hard bodies which
have undergone caseation and subsequent calcification. On section of the lungs the colour
presented by the cut surfaces is a peculiar pinkish-yellow, the divided blood vessels are occlud-
ed by yellow coloured clots.
Heart.—The pericardial sac contains several ounces of a light-brown coloured fluid. No
hæmatozoa can be discovered in it. The external surface of the heart presents numerous
dark-purple coloured patches, varying considerably in size : the largest being situated on the
anterior surface of the right ventricle involving also the inter-ventricular groove, and about
half an inch of the left ventricle nearest to the farrow. There are numerous circumscribed
and localized petechias dotted over the base of the heart laterally and posteriorly. The
right side of the organ is distended by a large mass of yellow clot running through and mak-
ing patent the communication between the right auricle and ventricle. The wall of the right
ventricle is slightly hypertrophied and there are a few ecchymoses beneath the endocardial
lining. The valves are healthy. The left auricle and ventricle are distended by similiar
clots, and these have maintained inter-communication between the two cavities. There are
numerous and extensive extravasations lying beneath the endocardial lining of the ventricle;
these for the most part involve the structure of the musculi-papillares, but on section do not
appear to dip into the muscular structure of the organ. The valves are healthy.
The abdominal cavity contains several pints of a pale-yellow coloured fluid, but the lustre
of the peritoneal covering of the intestines is normal- The Stomach contained a little semi-
digested food. The cuticular portion appears to be quite normal and healthy, but a colony
of hots covers an area of about three inches square. The villous portion presents a purplish
coloured patch, about two inches from the margin of the cuticular surface, an inch and a
half in diameter, and this patch is itself surrounded by small, circular ecchymoses, some dis-
tance apart with healthy membrane separating them. The colour is imparted to the above
patches, from extravasated blood lying under the mucous membrane of the organ.
Spleen weighs 4 lbs. 7½ounces. It is very irregular in shape. The base is quadrilateral
in form and of considerable thickness. There are no petechias on the surface, but there are
recent flakes of lymph on the surface of the organ. The tissue on section is firm and healthy
looking.
Liver weighs 19 lbs. The right lobe presents a dark-red colour, whilst the surface
of the left is opalescent. The whole surface of the gland, especially the left lobe, presents
a condition of peri-hepatitis ; lying under the capsule are innumerable, round, light coloured
spots vaiying in size from 1/16 th to 1/8 th of an inch. These give a densely mottled appearance
to the surface of the organ. On section the tissue presents a yellowish-red colour dotted over
with white spots which on scraping with a knife are readily enucleated. Many of these
bodies are hard and have undergone calcification.
Kidnevs are pale in colour. The stellate veins are particularly noticeable at the
inferior parts. The capsules strip easily in most parts, but are adherent at several points.
The tissue of the organ is a dirty grey in colour dotted over with very minute petechias.
On section, the only thing to attract attention is the extreme pallor of the cortical and
medullary substances.
Small intestines.—There are a few patches of ecchymoses scattered at long distances
apart on the surface of the mucous membrane, but no ulceration.
Cæcum and Colon contained fasces, but there are no extravasations' noticeable on their
mucous surfaces.
Bladder healthy.
The points of interest in this case are :—
(i). That blood containing hæmatozoa was directly injected into the general circu-
lation, and reproduced the disease after an incubative period lasting six days.
(ii). That the symptoms of swelling and œdema of the limbs became apparent on
the third day after the hæmatozoon had been discovered in the blood.
(in). That doses of 5 grains, 7.5 grains, and 11 grains of Potass : Bichromate in-
jected directly into the general circulation of the horse should have produced
no appreciable symptoms, with the exception of the localized œdema at the
point of inoculation.
(iv). That after a course of large doses of Potass : Bichromate, which attained to
360 grains in the twenty-four hours and amounted to 2,378.5 grains in all,
the animal should have maintained fairly good health, and the hæmatozoa
have still continued to be numerous in the blood.
B 1086—34 ap