cclxxviii
No. III.—Guinea-Pig.
Control Guinea-Pig.
Month and
Date.
1892.
September
16th...
17th...
18th...
19th...
20th...
21st...
22nd...
23rd...
24th...
25th...
26th...
27th...
28th...
29th...
30th...
October
1st...
2nd...
3rd...
4th...
5th...
6th...
7th...
8th...
9th...
10th...
11th...
12th...
13th...
14th...
15th...
16th...
17th...
18th...
19th...
20th ..
21st...
22nd .
23rd...
24th ..
25th...
26th..
27th...
28th...
29th...
30th...
31st...
November
1st...
Quan¬
ity in¬
jected.
1c.c.
1c.c.
1c.c.
1c.c.
1c.c.
1c.c.
1c.c.
1c.c.
1c.c.
1c.c.
1c.c.
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
Blood.
Normal in character ...
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
„
Inoculated with 0.2c.c.
Horse Surra blood.
Hæmatozoa absent
„ „ ...
„
„
...
„
few...
„
numerous.
„ „ ...
„ very numerous .
„ „ ...
„ numerous...
„ swarming...
„ „ ...
„ „ ...
„ „ ...
Hæmatozoa very nu-
merous
„ absent...
few
...
...
„
swarming
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
Death at 1 P.M.
Temperature
°C.
A.M.
38.3
39.1
39.3
39.1
38.6
37.7
39.3
40
40
40
40.3
39.3
40
39.8
39.7
39
39.6
39.3
39.7
39.3
40
39
38.5
38.8
38.6
39.7
38.4
38.5
39.2
38.2
39.1
39.1
38.2
38.2
38.6
38.2
39.8
37.7
39.1
39.6
39.5
38.4
39
39.4
39 2
39.2
35
P.M.
40
40.4
40.1
40
39.8
40
39.8
40.2
40.2
39.4
40
40.3
39.2
40.2
39.7
40.2
39.3
39.8
40.1
40.3
40.3
39.2
39.8
39.6
40.1
39.5
39.6
39.6
39.4
39.4
40.3
38.8
39.1
39.2
39
39.1
40
40.2
40
39.8
39.6
39.8
40
40.6
39.8
39.8
...
Month and
Date.
October
3rd...
4th...
5th...
6th...
7th...
8th...
9th...
10th...
11th...
12th..
13th...
14th...
15th...
16th...
17th...
18th...
19th...
20th...
21st...
22nd .
23rd...
24th...
25th...
26th...
27th...
28th...
29th...
30th...
31st ...
November
1st...
2nd...
3rd...
4th...
5th..
6th...
7th...
8th..
9th..
10th..
11th..
12th..
13th..
14th..
15th..
16th..
17th..
18th .
19th...
Quan¬
tity in¬
jected.
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
...
Blood.
Inoculated with 0.2c.c.
Horse Surra blood.
Hæmatozoa absent ...
„ „ ...
„ „ ...
„ „ ...
„
few
„
numerous .
„
few
„
numerous .
„ very numerous .
„ swarming
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ very numerous .
„ few
„
„
...
„ numerous
„ very numerous .
„ „ ...
„ few
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
Hæmatozoa numerous .
„ very numerous
„ swarming
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ very numerous
„ „ ...
„ swarming
„ „ ...
„ „ ...
„ „ ...
Temperature
°C.
A.M.
...
38.6
38.6
39.3
39.1
39.8
39.3
40.2
39.5
38.6
39.1
39.7
39.3
39.3
38.7
38 6
38.2
38.2
38.6
39.4
38.4
38.6
39.2
39.2
38.2
39.4
40.6
39.4
38 .8
38.4
37.2
38
38.8
39.4
39.4
40
39.4
39.8
39.8
39.2
38.4
38.6
38.6
38.3
38.8
37.4
38
36
P.M.
40
40
39.8
39.7
39.4
40.4
40
40.2
39.7
39.7
39.6
39.8
39.7
40.3
39.3
39
39.9
39.8
39.4
39
39.4
39
39.4
39.6
40
40.4
40.6
40
39.6
39.4
39
39.4
39.9
40
40.2
49
30.8
40
40.2
40
40.4
40
39.6
39.6
40
39.6
40.2
Death.
Remarks.— For this experiment three Guinea-pigs were subjected to daily injection
subcutaneously with a mixture of proteid material mixed with Glycerine and Water, the
proteid having been obtained from the blood of a horse suffering from Surra. At a later
date the above, together with a fourth as a Control animal, were each inoculated with 0.2 c.c.
of blood containing numerous hæmatozoa, drawn from the Jugular Vein of Horse No. LXXI,
the subject of naturally acquired Surra.
(i).
(ii).
(iii).
Control
Guinea-pig received 0.5 c. c.
„
„
0.75 c. c.
1.0 c. c.
×
×
×
11 of Proteid and lived 70 days.
11
11
„
„
„
22
29
47
„
„
„
It will thus be observed that Guinea-pig No. (i), which received the smallest quantity
of Proteid material, survived animal No. (ii) by 48 days, No. (iii) by 41 days and the
Control by 23 days.