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when applied in substance or strong solution, it produces no local irritation, but
acts as a local anaesthetic. It also prevents the development of giant cells, and
may thus prevent morbid tissue growth.
Iodoform.
Case No. VIII.—As
this animal was a strong one, it was decided to try the effect
of Iodoform on the hæmatozoon. Accordingly on the 30th
December 1890, the organism being absent, three grains of
Iodoform in ether were injected subcutaneously, and on the following morning a further
dose of four grains was administered in the same way, but in the meantime the organism
had re-appeared in the blood. On the 1st January 1891, five grains of Iodoform in
ether were directly injected into the Jugular Vein, but on the 2nd the hæmatozoon was
present in increased numbers ; fourteen grains were therefore directed into the general
circulation, with no untoward symptoms resulting. On the following morning, the 3rd of
January, twenty-five grains of Iodoform were injected directly into the right Jugular Vein.
But, although the animal was carefully watched throughout the day, no sign of uneasiness,
or other symptom was manifest. On examination of the blood, on the morning of the 4th,
the hæmatozoa were found to be numerous and active ; as therefore the Iodoform appeared
to have no action whatever upon the hæmatozoon, it was decided to try some substance
known to have a powerful action upon other organisms. For this purpose Mercuric
Perchloride was chosen. At 11 A.M. Hydrargyri Perchloridi, Glycerini 10 c.c. and distilled
water 6 c.c. carefully mixed, were injected directly into the right Jugular Vein. One hour
and twenty minutes after the administration of the drug, the animal lay down having passed
faeces of a pultaceous character, on three occasions previously, and urine twice. At 1 P.M.
the temperature was 39°C, having previous to the operation registered 38.2°C. P.52. At
this time, as also at 3 P.M., the animal passed a quantity of pale, straw coloured urine, contain-
ing a slight trace of albumen, and some phosphates ; the blood on both occasions presented
numerous hæmatozoa on microscopical examination. The temperature at 5 P.M. had become
considerably elevated, 4l.6°C, but from the chart it is difficult to be certain that the elevation
was in any way influenced by this administration of the drug, as on the day but one pre-
viously the same degree was registered within one or two points.
On the following morning, the 5th January, the temperature had regained the exact
degree registered previous to the exhibition of the Mercury, but the hæmatozoon was still
present and active in the blood, although in small numbers. During the next five days
the organism was only absent for twenty four-hours, namely, on the third day, and on its
re-appearance presented itself in increased numbers. Serious symptoms of a gastro-intesti-
nal nature were present during the last five days of the animal's life, as evidenced by the
fact that the dung was coated in places with a small quantity of blood, and that absolutely
no faxes were passed between the evening of the 7th, and the day of its death.
Oleum Terebinthinæ.—"Turpentine is a general stimulant acting on the
heart and vaso-motor centres and nerves. Injected into the veins of a horse,
it is said to cause fatal pulmonary congestion. It poisons lice, acari, entozoa,
"whether lodged in the bowels, bronchial tubes or skin, and arrests fermentation
and putrefaction ; also destroys vibriones and bacteria " (Finlay Dun).
On microscopical examination it was observed that the effect of this oil
in minute quantities was the production of a torpid condition, shortly followed
by death. Koch's results show, that spores have their vitality diminished
in one day on exposure to turpentine oil, and that after a period of five days'
exposure to the same material, the spores are destroyed, and their germination
prevented.
Oleum : Terebinthinæ
Case No. XIV.—This animal being in fair condition and apparent good health was
thought to be a good case for trying the effect of Oleum
Terebinthinæ upon the hæmatozoon. On the morning of the
sixth day of the disease—temperature 38.5°C., continued fever having previously been
present during a period of five days, and the Surra organism varying between few and
very numerous in the blood, 8 c. c. of Oleum Terebinthinæ were injected subcutaneously,
but with no visible effect. 'The temperature rose the same evening to 38.8°C. and in the
morning had again fallen to 38.4°C., P. 40, R. 33, the hæmatozoon still being present in
small numbers in the blood. As such a slight effect had been produced by the previous
dose, it was determined to directly inject a similar quantity into the general circulation,
consequently at 12.40 P.M. 8 C. C. were exhibited in the above mentioned way. Five
minutes later, the pulse from being fairly good had become barely perceptible, the respi-
rations had increased to 60 per minute from 33, and muscular twitchings were present in
both flanks. The animal lay down and, almost immediately, assumed the erect position
again. Liq : Ammoniæ in equal parts with water was injected subcutaneously at 1 P.M. and
was again followed by a second injection twenty minutes later. The pulse shortly after-
wards became stronger, and the animal lost all discomfort produced by the drug. On
examination of the blood, the hæmatozoa appeared torpid, and to have lost all power of
movement. The temperature fell that evening to 38°C., but on the following morning
had become somewhat higher, and the hæmatozoa were still present in exactly the same