111
administered daring the day. From the 29th the general condition of the animal was un-
changed, and. there were few active hæmatozoa in the blood. The amount of the medicine
was therefore again increased, the animal receiving Carbolic Acid drachms xxiv, and Iodine
drachms viii. On the 30th no effect appeared to have been produced on the health of the
animal by the drug, the appetite and general appearance being as before. The only effect
noticed being in connection with the urine, which assumed a brownish-black colour, and
exhibited an inky line on the. addition of a small quantity of Nitric Acid. On microscopical
examination of the blood, the organisms were found to be numerous. The animal received
during this day Carbolic Acid drachms xv, and Iodine drachms viijs. On October 1st
the animal showed the first symptoms which might be referred to the action of the drugs,
appearing slightly uneasy after taking food. On microscopical examination of the blood,
no hæmatozoa were detected. Taking into consideration the symptoms evinced by the
animal, it was decided to discontinue the administration of the medicine, as it was deemed
to have had a fair trial in this case, when it is considered that the administration of pure
Carbolic Acid seventy-six drachms, and Iodine thirty-four and a half drachms, produced so
little effect on the organisms. It is apparently evident, that their use as remedial agents
in this disease is of little practical value. From October 1st to the 4th no organisms were
detected in the blood, the uneasiness passed off, and no further effect of the medicine was
noticeable. On the morning of the 4th October a few hæmatozoa were discovered in the
blood, and it was consequently decided to again adopt treatment with Cinchona Alkaloids
and Arsenic. Accordingly Cinchona Alkaloids one and a half
Cinchona Alkaloids and Arsenic. drachms, and Arsenic grs. iV were given twice during the
day, and these doses were continued until the evening of the 6th, when they were increased
to two drachms and five grains respectively, and these doses were continued until the even-
ing of the 10th, when they were again increased to two and a half drachms, and six grains
respectively, and continued until the evening of the 14th, when they were increased to three
drachms, and seven grains, and on the evening of the 16th the Arsenic was increased to
eight grains. The disease continued to steadily progress during this time, and very little
effect was produced upon the temperature.
Case No. LXXL—It
was decided in this case to try again the effect of the mixed
Cinchona Alkaloids and Arsenic on the hæmatozoon, as it had
Cinchona Alkaloids and Arsenic shown promise or efficacy in that of Horse No. LXV, in which
case after a short exhibition of the drugs, the hæmatozoon was kept in subjection for a period
of twenty-seven days. Consequently as a fresh trial was resolved upon, the animal was first
put upon small doses, beginning with one drachm of the Alkaloids and four grains of
Arsenic, given in the form of the Liq : Arsenicalis. On the morning following the first
dose, the temperature was found to have fallen over a degree, and the hæmatozoon was
absent from the blood, the temperature remained low, and the organism absent for the
next five days, during which period two doses of the medicine were administered daily.
On reference to the Chart, it will be seen that on the 9th day of the disease the hæmato-
aoon again appeared in the blood ; consequently on the 10th, the doses of Alkaloids and
Arsenic were increased to one and a half drachms and five grains respectively ; these were
continued for a period of eight days, during which time the hæmatozoon varied in numbers
between few and very numerous. On the 18th day of the disease a further increase in the
doses was agreed upon, and during the next four days, they were put up to Alkaloids two
and a half drachms, and Arsenic grains vi, and for the latter half of this period the organism
was absent from the blood, but re-appeared on the 22nd day, and remained on the 23rd at
few. On the former date the Alkaloids were increased to three drachms, and the Arsenic to
grains viij, and from the 23rd to the thirty-fifth day of the disease, on which latter date the
animal succumbed, the hæmatozoon was entirely absent from the blood. During the thirty-
two days the animal was under treatment, three hundred and fifty-five grains of Arsenic in
the form of Liquor Arsenicalis, and one hundred and fifty-four and a half drachms of the
mixed Cinchona Alkaloids were administered.
Quinine.—Quinine seems to enter into combination with albumen. It lessens
protoplasmic and amoeboid movements, and destroys low animal and vegetable
organisms. Quinine diminishes and in large doses arrests fermentation. It is a
powerful antiseptic, and a dilute solution will preserve meat, milk, butter, or
wine for a length of time.
Quinine and the other Cinchona Alkaloids destroy bacteria, their power
diminishing in the following order :—Quinine, quinidide, cinchonidine, and lastly
ciiichonine.
Koch observed that when anthrax bacilli were exposed to the action of a
solution of Quinine 1 to 830, the growth of the bacilli was hindered, but that a
solution of 1 to 625 prevented their growth altogether.
Case No. LXXII.—This
animal belonged to the Bombay Tramway Company
On the morning of the 7th October 1892, the "Surra" hematozoon was discovered
on microscopical examination of its blood. On admission to the Laboratory
Hospital the following note was made : " Bay Gelding, aged five years, appears to