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the membranæ nictitantes, and there was a slight watery discharge from the nostrils accom
panied by cough, and a small swelling was discovered, painful on pressure, over the left orbit.
By midday on the 19th, the temperature was 39.7°C., but during the following night fell to
37.3°C., the swelling over the left eye had increased in size. Three doses of Arsenic making
or. xiv in all were given on the latter date, but notwithstanding the temperature continued
to rise until 5 P.M., when it registered 39.8°C., and attained a maximum of 40.1 o C. at midday
on the 21st, on which day the Arsenic was increased to gr. vss. per dose. The abscess burst
in the night, and early on the morning of the 22nd a further quantity of pus was evacuated,
and the temperature fell to 38.1°C., but the respirations increased to 20 per minute, the
pulse being 64. On the 24th, the animal presented a dull appearance, the ordinary symp-
toms of the disease were present, and in addition there was swelling and œdema of the right
hind limb, but it was not painful on manipulation. The pulse was small and frequent—88, but
the breathing tranquil, respirations 12—and the appetite was good. Temp. 38.8°C. and the
hæmatozoon absent from the blood. The urine however for the first time during the
duration of the disease contained albumen, 1/7th. Death took place on the 25th January, at
7-45 A.M. During the exhibition of Arsenic in this case, 427 grains were given, and the
hæmatozoon was absent from the blood on 44 consecutive days.
Arsenic.
Case No. LXXXI.—A Grey Herati Mare, aged 9 years. On admission it was in very
good condition, but on examination presented some symptoms
of Surra, and the hæmatozoon was present in small numbers
in the blood.
This animal proved most intractable, to a treatment consisting of Arsenic in the form of
Liq: Arsenicalis, which was given in full physiological doses at first, and gradually increased
or diminished, according to the condition and symptoms exhibited.
Treatment was commenced on the morning of the sixth day of the disease, the hæmato-
zoa at that time being numerous in the blood. The first intermission occurred on the 8th
day of the disease, after sixteen grains of Arsenic had been taken by the animal, and was a
natural phase of the disease, and in no way attributable to the action of the chemical. The
second paroxysm lasted three days, 9 th, 10th and 11th, during which period the hæmato-
zoon was present in small numbers in the blood. On the evening of the last-mentioned day, the
animal passed some ounces of urine of a dark red colour, which on microscopical examination
was found to contain only a very few blood casts, and free red corpuscles. This was
however the commencement of a period lasting six days, during which the urine was found to
contain albumen, varying in quantity from a trace to 1/5th, together with enormous numbers of
casts, from narrow, medium to the broad uriniferous tubes, which were for the most part
granular in character, although a few blood casts were observed. The dose of Arsenic during
the presence of the albumen was decreased gradually, until on the evening of the 15th day,
and morning of the 16th, none was given. As, however, the hæmatozoon again made its ap-
pearance, constituting the commencement of the third paroxysm, the former dose was repeated,
and for the next four days during which the paroxysm lasted, was continued, making a total
for that period of 39 grains.
The third intermission lasted one day, the 21st of the disease, on which the animal
received Arsenic gr. x.
The fourth paroxysm lasted six days, and 31 grains of Arsenic were given.
The fourth intermission extended from the 28th to the 32nd day inclusive, and as this
was considered to be a favourable opportunity of placing the animal under the effects of the
chemical, the doses were increased ;. consequently it received 64 grains of Arsenic-
Notwithstanding the before-mentioned daily increase of the dose from xi to xiv grains, a
fifth paroxysm occurred on the 33rd day of the disease, lasting 5 days, during which period
the hæmatozoa increased to very numerous in the blood. Only 30 grains were given on the
first two days, as on the remaining three the animal refused water.
A fifth intermission lasted one day, the 38th of the disease, on which x grains of Arsenic
were given. And finally a sixth,; paroxysm occurred lasting from the 39th to the 41st, both
days inclusive. Only x grains were given, owing to the condition of the animal.
Death took place on the 1st day of the 6th intermission, or 42nd day of the disease.
Arsenic.
Case No. LXXXIL—On the morning of December 23rd, 1892, the sixth day of the
disease, Temp.. 39.3°C., P. 64, R. 20, hæmatozoa few in the
blood, the animal was subjected to an Arsenical treatment,
consisting of grs. iv, in the form of Liquor Arsenicalis P. B. minus the Tinct : Lavandulæ Co.
As in the previous cases, the medicine was not administered, but placed in the animal's
drinking water at 8 A.M. and 6 P.M. The evening temperature after the first dose, attained
a maximum of 40.6°C., P. 64, R. 28. On the morning of the 8th day of the disease, after the
animal had received Arsenic grs. xvi, the temperature was found to have fallen to 38.4°C.
and the hæmatozoon was absent from the blood. On the 9th day the temperature registered
only 37.8°C. From this date until the 62nd day of the disease, when the treatment was dis-
continued, the temperature only on one occasion reached 39°C, viz., on the evening of the*