114
Case No. LXXIV.—This
animal, a Grey Arab Gelding, No. 492, aged 14 years,
belonging to the Bombay Tramway Company, was recognized as ailing on the 14th October,
1892, after having been in the country for a period of four years.
Santonin.
Iodic: Hydrarg.
Liq. Arsenicalis.
On the same date it was taken into the Infirmary suffering from debility, and had fever
off and on until November 7th, when the hætnatozoon was discovered. There was a tem¬
perature of 40.8°C. on the 27th October, and there is little doubt that the organism was
present in the blood at a date considerably anterior to that on which it was found. The
animal arrived at the Laboratory Hospital on the morning of the 9th November, the twenty-
seventh day of the disease. In this case it was decided
to try the effect of Santonin: consequently on the evening
of the 10th the organisms being few in the blood, and the
temperature 38.5°C, thirty grains were administered, and a similar dose was repeated on
the 11th, followed by 01. Lini: Oj. on the morning of the 12th, but in the meanwhile the
temperature had attained 41°C., the hæmatozoa were very numerous in the blood, and the
visible mucous membranes were stained a bright yellow in colour. The oil produced three
movements of the bowels in the first six hours, but the faces were formed, and no symptoms
of diarrhoea supervened that evening. On the following day the evacuations were of a
semi-fluid character, the temperature had fallen 2.8ºC. since the previous evening, the
hæmatozoa were numerous in the blood, and the disease was progressive. As on the 14th
the diarrhoea continued, one and a half ounces of Tinct: Opii were given, which checked
it during the day. The same evening, however, the temperature again became elevated
40.8°C, and on the following morning the hæmatozoa were found to be very numerous.in
the blood; but Quinæ : Sulph : Зiij reduced the temperature to 39°C, and the hæmatozoa
disappeared. As the Santonin had no action on the hæmatozoon, it was decided to again
give the double Iodide of Potassium and Mercury a trial.
Two doses of four grains each were given on the 16th, and the
doses were increased to six on the seventeenth, but as the
temperature showed signs of again becoming elevated a drachm of Quinine was administered
in the evening, which reduced the temperature on the morning of the 18ch to 37.6°C. and
the organism still remained absent. The same dose was repeated twice during the day.
From the 19th to the evening of the 21st the drug was persisted in. The temperature on
the evening of the latter date had gradually risen to 40.3°C, and the hæmatozoa had
increased from few to numerous in the blood, whilst the urine contained, on the former date,
one-ninth part of albumen, together with numerous granular casts. Three drachms of
Quinine were therefore given to reduce the temperature, but as no alteration in it had taken
place on the morning of the 22nd, it was decided to subject
the animal to a treatment of Arsenic alone, simply giving the
dose in the form of Liq : Arsenicalis in the drinking water.
After the first dose the temperature fell to 40°C, but at the time when the second dose
was given, it had again risen to 40.8 o C.
On the morning of the 23rd, the thermometer registered 39.4°C. in the rectum, the
dose of Arsenic was increased to six grains twice daily, and by the same evening the tem-
perature had fallen to 390.1°C. On the morning of the 25th, the temperature was 36.5°C.
and the organisms had been absent from the blood for three days, but the former suddenly
rose to 39.4°0. at the time of the midday observation, but fell to 37.8°C. the same evening.
On the morning of the 27th the hæmatozoon having been absent for four days, again made
its appearance with a temperature within normal limits, but from that date until midday on
the 9th December the dose of Arseuic grs. xii per diem was continued, and the temperature
although oscillating did not exceed 38.4°C. and the hæmatozoon which had disappeard
from the blood by the morning of the 28th November, remained absent. On the evening
of the 9th December the temperature rose one point, and on the following morning it was
two degrees lower, but rose again to 39.3°C. by five P.M. This was the maximum recorded
during the four days previous to death, which occnrred on the morning of the 15th Decem-
ber, the sixty-third day of the disease. At the time of death the hæmatozoon had been
absent from the blood for a period of eighteen days.
Potass (KHO).—This is a protoplasmic poison, destroying muscle, nerves
and nerve centres, when applied to them for a sufficiently lengthened period and
in a concentrated form.
It does not paralyse the heart when given by the mouth, but when injected
directly into the veins, it produces transitory excitement, clonic spasms, para-
lysis and death. Large closes cause a rapid fall of blood pressure and pulse rate.
Smaller doses cause a slight fall of both pulse-rate and pressure, followed by a
rise of both. Large doses are irritant, corrosive, and cardial sedatives, medicinal
doses are antacid, febrifuge and diuretic.
Liq. Potassæ.
Case No. LX XVI.—This animal, 11 years of age, four years in the country, suffered from
fever on 8th November 1892. The Surra hæmatozoon was discovered in the blood on the 25th
instant, and the animal was received at the Laboratory Hospital on the following day. On its
admission,the temperature was 39.2C.,P. 72, R. 12, and the blood
contained a few organisms. In this case it was determined to