33
evening of the sixth day rose a further 2.5°C., attaining 40.9°C. It then gradually
fell until the first appearance of the organism in the blood which occurred on the
morning of the tenth day, or nine days after inoculation. The fever then became
continued with irregular periods of intermission until death, which occurred on
the twentieth day of the disease, the hæmatozoon having been absent three days.
Sub-endocardial lesions were found invading the right ventricular walls of the
heart but were absent from the left, and a tumefied and congested condition of the
Schneiderian membranes in the nasal passages.
Horse. No. LIV.—Chestnut Country-Bred Horse, aged. Subcutaneously
inoculated on the 26th December 1891 with 0.1 c.c. of blood swarming with
hæmatozoa taken from the Jugular Vein of Horse No. LVI ante mortem. On the
day following the operation a small raised tumor appeared at the seat of inoculation,
which continued to increase in size until the morning of the fourth day when, on
manipulation, the animal showed signs of uneasiness. On passing a Pravaz needle
into the tumor and on microscopical examination of the blood-stained fluid
withdrawn, several hæmatozoa were observed, but no organism were found in
the blood of the general circulation. On the following day the part became
flaccid and the tenderness disappeared, and on examination of the blood hæma-
tozoa were discovered in small numbers. The latent period occupied four days.
The temperature at the time of inoculation registered 35.8˚C., but the same even
ing rose to 37.4°C., and from that date until the fourth day of the disease the
fever assumed a remittent type, characterized by midday exacerbations and
morning remissions. On the morning of the fifth day the temperature suddenly
fell 4.6°C. Then followed a period of apyrexia, lasting four days. This paroxysm
being followed by four similar ones, marked by gradual rises to 41°C. or42°C. in
the evening, but on the last occasion the maximum was attained at midday, and
these were followed by sudden falls in the temperature during the night of from
2.1°C. to 4.6°C., and subsequently by fever-free periods of three to four days.
During the last fifteen clays of the animal's life the thermometric curves
demonstrated a return to the continued type of fever accompanied by daily
remissions. Death occurred on the 6th February 1892.
Autopsy.—Emaciation, oedema of the extremities and under-surface of
abdomen. Lungs.—Few sub-pleural ecchymoses, tissues stained yellow. Heart.—
Sub-pericardial extravasations, yellow-coloured, gelatinous exudation, round the
base of the organ, large sub-endocardial extravasations involving the musculi
papillares in the left ventricle. Spleen enlarged, sub-capsular petechias. Liver
enlarged. Intestines presented numerous small extravasations lying beneath the
mucous membrane, with here and there patches of congestion, but no ulceration
or parasites.
Horse No. LV.—Grey Country-Bred Entire, aged. Subcutaneously inoculat
ed on 5th February 1892, with 0.1c.c. of blood swarming with hæmatozoa taken
from the Jugular Vein of Horse No. LIV ante mortem. A raised tumor appeared
one inch in diameter on the day following the operation and gradually increased
until the fourth day, when it became stationary in size but was accompanied by the
usual symptoms. On the morning of the seventh day the tumor presented a
soft and flaccid appearance and the hæmatozoon was found present in the blood
of the general circulation. The latent period occupied six days. Previous to
inoculation the temperature presented marked daily remissions and exacerbations
which continued until the third day when they became much less marked, although
the degree registered each day attained the normal limit. On the day previous
to the appearance of the hæmatozoon in the blood there was a sudden rise from
37.4°C. to40°C. followed by the continued type of fever with marked daily remissions
until the evening of the fifth day of the disease when 41.6°C. was registered. A
fall of 3.5 0 C. followed with a fever-free period of two days duration. Two exacer-
bations attaining a maximum of 42°C. and 41.7°C. occurred on the evenings of the
9th and 15th clays of the disease with subsequently free periods. The last ten
or eleven days previous to death, which occurred on March 10th, the continued
type of fever returned accompanied with marked remissions.
Autopsy.—Emaciation, œdema of the extremities. Pericardium contained
several ounces of clear, orange-coloured fluid. Gelatinous exudation round the
base of the heart ; slight thickening of the endocardial lining in the ventricles and
B 1086—9