106
began to rise at once, and by midday attained 89.2°C., and when recorded at 5 P.M., was
found to register 39.8°C. On the morning of the 7th the temperature was 41°C.,
the animal had not lost in condition, and the oedema previously present appeared
to have diminished during the treatment, as well as there being an improvement in the
gait. The hæmatozoa were still numerous in the blood. The dose was again increased
and 7 c.c. were given as before; by five P. M. the thermometer showed a fall of three
quarters of a degree Centigrade, and during the night a somewhat sudden fall of 2.5°C. to
37.8°C. took place, and the hæmatozoon in the blood fell in numbers to few. There ap-
peared, however, an eruption of urticaria general in character, but not particularly well
marked. This was not deemed of sufficient importance to contra-indicate the administration
of the drug, and consequently the animal again received a similar amount to that which
was the day before injected. During the day and the following night the temperature
remained low, and the eruption, which had commenced to fade the evening previously,
had now entirely disappeared. On examination of the blood the organism was found to-
be again present in large numbers, and as 2.6 grammes (39 grains) had been administered
during a period of six days, without producing any apparent action on the hæmatozoon,
it was deemed advisable to substitute this by some other form of treatment. It was
therefore decided to make use of the following solution in the further treatment of the
case :
R.
Iodum—1.5 grammes.
Potass Iodidi—7.5 grammes.
Aquam ad.—100 c. c.
Instead of continuing the subcutaneous method previously employed, another one was
substituted, namely, the direct injection of the fluid into the trachea, by means of a Pravaz.
Syringe, the needle being introduced between the cartilaginous rings. It was hoped that
by this means the medicament being diffused through the lungs would have an
opportunity of being brought into contact with the minute network of capillaries in these
organs, and of acting upon the hæmatozoon contained in the large mass of blood circulating
through them, and that its effect would be thus increased.
Iodine, Pastass. Iodid
Consequently on the morning of the 9th December, the temperature of the animal
registering 39.3°C., a small quantity of the solution contain-
ing
Iodin.12,gramme
and
Iodide
of
Potassium 0.6 gramme
was injected into the trachea, but did not appear to cause the animal any discom-
fort. The temperature the same evening rose to 40°C. and on the morning of the 10th
had reached 40.3 o C. the hæmatozoon still being numerous in the blood. A similar
quantity was now injected and in the evening the temperature rose to 40.6°C. On
the morning of the 11th the temperature was 40.3°C. and again the organism
was found to be numerous in the blood, so it was decided to increase the quantity of the
medicament. At 9 A.M. a quantity of the solution containing Iodine 0.24 gramme,
and Potass Iodidi 1.2 grammes was injected, the temperature fell slightly during the day,
and on the following morning registered 39.1°C., the organism having been reduced at
the same time to few. The increased dose of the previous day was again employed, and
the temperature after rising to 40°C. the same evening, fell on the morning of the 13th to
38.6°C, and the hæmatozoon was found to be absent from the blood. The reduced dose
of Iodine 0.12 gramme and Potass Iodidi 0.6 gramme was again utilized in order that a
minimum amount of irritation only might be produced. The temperature registered
38.6°C. on the morning of the 14th, but the hæmatozoon was again present in small
numbers; a similar quantity of the drugs was again injected, the evening temperature
rising to 39.2°C..and remaining at the same height until the morning of the 15th, when
on microscopical examination the organism was found to be numerous in the blood. On
this day the animal was suffering from a slight cough, but as it was deemed inadvisable
to discontinue the administration of the medicament, it received a similar amount of the
solution to that given on the day previously. The thermometer registered 40.2°C. at the
evening observation. On the 16th a slight remission took place, but after an injection of
the solution containing Iodine 0.48 gramme and Potass Iodidi 2.4 grammes, the degree
registered was 41.1°C On the morning of the 17th the temperature was found to be
40.1°C., a fall of one degree during the night, and the hæmatozoon to be reduced in
numbers. Accordingly as there was no contra-indication, a similar quantity to the last dose
was injected. On the morning of the 18th there was considerable swelling and oedema.
at the seat of the injections, and for some distance round the trachea. There was also
increased oedema of the sheath. and under-surface of the abdomen, and the temperature
was 40.4 o C. As the hæmatozoa were decreased in number, the ' locale' of the injection
was changed, and the solution was subcutaneously administered, the animal receiving
Iodine 0.15 gramme, Iodidi of Potass 0.75 gramme, the temperature remaining at or
about the same degree until the following day, the 19th, when taking into consideration
the amount of the respective drugs administered and the condition of the animal, it was-
thought that a fair trial.had been given to this form of treatment.
Iodoform (C H I 3 ).—This chemical has the property of destroying certain
bacilli, and is an antiseptic and deodorizer of very considerable power. It also
destroys leucocytes. It has been used with considerable success in the treatment
of gangrenous stomatitis. This drug also possesses one great advantage, that