lxxxiii
Kidneys.—The right weighs 1 lb. 8½ ozs.; the left 1 lb. 9½ ozs. The capsules strip easily
and reveal some injection of the stellate veins, but no petechia}.
On section.—The cortical portion of the organ presents a congested appearance, the
Malpighian corpuscles being red in colour, the medullary portion appears healthy.
Stomach.—The organ is semi-distended. On section the cuticular portion presents a
normal appearance, as also the mucous membrane of the villous portion, with this ex-
ception that there is a tumor with a hole on its summit, lying on the villous side of the
line of demarcation at its most dependent part due to (spiroptera megastoma).
The Intestines.—The mucous membrane of the large and small intestines presented a
normal appearance.
Remarks.—This animal belonged to the Bombay Tram way Company and was purchased
on January 23rd, 1890. Until December 2nd, 1892, it appeared to be in good health, but
on that date was observed to be ailing and was taken into the Infirmary at Parel. The
temperature at that time was elevated, but fell during the day and remained normal during
the two following days. The blood on microscopical examination presented a healthy
appearance. On the 5th December the temperature began to rise and steadily continued
to do so until the evening of the 6th, when it registered 39.3°C. On this date the
hæmatozoon was first discovered in the blood.
The animal was admitted into the Laboratory Hospital on the morning of the 7th.
Temperature 39.7°C. It presented a fairly bright appearance, although the symptoms of
Surra were well marked and the Trypanosoma were swarming in the blood. On examina-
tion of the chart, however, it will be observed that the temperature was falling on
December 2nd, and attained a minimum on the morning of the 3rd. Taking this together
with the three days' intermission which followed the general condition of the animal, the
fact that the visible mucous membranes were tinged yellow, the presence of albumen in the
urine, there can be little doubt that at least one paroxysm must have occurred previous to the
animal coming under observation. On the evening of the 7th with a temperature of 39°C.
P. 52. R. 32. four grains of Arsenic were administered, as from previous experiments this
drug was found to have a far less irritating effect on the gastric mucous membrane, when
given by itself than in conjunction with the mixed alkaloids and to have if anything a more
prompt action on the hæmatozoon when exhibited alone. The following morning the thermo-
meter registered 3S . 5°C, the respirations had fallen to 20 but the pulse remained the same.
The organism had, however, decreased in number in the blood, and there was still a trace of
albumen in the urine. During the 9th, the animal presented a somewhat dull appearance.
The visible mucous membranes remained yellow in colour, but there were no conjunctival
petechias present. The hæmatozoa were few in the blood. The dose of Arsenic was
increased to grains five bis die. On the morning of the 10th the temperature was 38.3°C.
and the hæmatozoa numerous ; notwithstanding that the animal showed some slight improve-
ment during the day several ascarides were passed with the dung. The same evening the
temperature rose to 4.0.1°C, but by the following morning had again fallen to 39.2°C. and
the organism was absent from the blood. From this time the temperature gradually rose
until it attained a maximum of 41°C. at 5 P.M. falling again to 40°C. on the morning of the
12th, but again attaining 41°C. the same evening. On the morning of the 13th the thermo-
meter registered nearly a degree and a half lower than that on the previous evening,
and duering this day and until mid-day on the 14th continued to fall, attaining a minimum
of 38.5°C. On the morning of the 15th the animal had developed a cough and the
temperature rose 1.3°C. during the day, but nothing could be made out on auscultation. On
the 16th the temperature varied between 39.5°C. and 39.7°C The cough had become more
troublesome, especially when the animal held its head in the dependent position. The same
evening the pulse rose to 72 and the respirations 24 per minute. On the morning of the
17th the temperature was 39.6°C, the pulse 64 and the respirations 16. The hæmatozoon had
now been absent from the blood for seven clays and during that period the animal had taken
in its drinking water six grains of Arsenic night and morning. At five o'clock the same
evening the temperature registered 40.6°C, the pulse 64, respirations tranquil, 16, but the
animal did not appear to be any worse and ate its evening ration of corn and hay. At
midnight, however, it became suddenly worse and died at 2 A.M.
RECORDS OF URINE.
Animal—Australian
Mare. No. LXX VIII.
Date, December 7th, 1892. Disease,
Naturally contracted Surra.
Date.
1S92.
December 7
8
9
„
10
„
11
„ 18
Quantity.
...
Colour.
Turbid, viscid, orange...
Clear,
do.
Turbid
do.
Turbid, viscid, yellow...
Do.
do.
Death.
Re-action.
Alkaline ...
Do.
Do.
Do.
Neutral ...
Sp.
Gravity.
1,020
1,019
1,016
1,020
1,024
Albumen.
A trace.
Do.
Nil.
Nil.
Nil.
Phos-
phates.
Nil.
Nil.
Nil.
Nil.
Nil.
REMARKS.
Caco 3 and Oxalate crys-
tals ; no casts.
Do.
do.
Do.
do.
Do.
do.
Do.
do.