29
nostril, which latter on the 25th presented a greenish colour and the consistency
of white of egg. On the 28th the œdema of the abdominal walls measured 10¾"
across at the sternum, 17" at the umbilical region and 19 inches in front of the
sheath. This layer of semi-solid œdematous material measured five inches in
thickness (vide photograph). Epistaxis occurred on the 1st June 1891.
Autopsy. —Emaciation, semi-solid œdema under belly ; oedema of the. sub-
pleural connective tissue. Lungs.—Tissues stained yellow colour; localized em-
physema of the apices and free borders. Heart, yellow (edematous material round
the base of the organ and accompanying the coronary vessels in their course.
Left ventricular valves presented two patches of extravasation in their sub-
stance one in each valve. Stomach, villous portion, mucous membrane thick-
ened and presenting a purple colour. Liver very much enlarged. Spleen nor-
mal. Kidneys, several ecchymoses dotted over the surfaces of both organs. Small
intestines.—Few patches of ecchymoses lying in the mucous membrane. Large
intestines, healthy. Twelve grammes of Sodii Salicylas : were administered on
the 14th May, but no lowering effect was produced on the temperature thereby.
Horse No. XXII.—Brown Country-Bred Pony, aged. Subcutaneously
inoculated on 29th May 1891, with 1.0 c.c. of blood taken from the Jugular Vein
of Horse No. XXI ante mortem. Swelling and oedema appeared at the seat of
inoculation forty-eight hours later and had increased still more after sixty hours
with the other symptoms usually observed. On the morning of the fifth day or
ninety-six hours after the injection of blood, the tension and tenderness of the
part had to some extent disappeared and the hæmatozoon was discovered in the
blood of the general circulation. Continued fever existed from the very first,
accompanied by remissions and at irregular periods by intermissions of short
duration. The evening before death the temperature fell to 36'2°C. and remained
at the same degree until the following morning when it suddenly rose 3°C. in a
few hours. Death occurred on the twenty-first clay of the disease, June 22nd.
On the 1st June an ulcer, one-third of an inch in diameter, situated on a raised
base appeared at the margin of the right nostril, from which haemorrhage took
place during the nights of the 14th and 16th of the same month. On 12th June,
the eleventh day of the disease, an Urticaria appeared involving the skin of the
neck, shoulders and chest with a few patches over the abdomen, which disap-
peared after twelve hours. On the 19th clay of the disease a slight opacity of
the right cornea was noticed and an ecchymosis of some size lying on the sclero-
tic and bordering on the upper and inner edge of the cornea.
Autopsy.—Emaciation, sub-pleural extravasations, extravasation involving
one of the right auriculo-ventricular valves. Liver, large, presented signs of old
perihepatitis. Spleen, enlarged, few petechias under the capsule. Kidneys,
healthy. Stomach, cuticular portion contained œstridœ, was stained yellow; the
mucous membrane of the villous portion considerably thickened and congested
and covered with glairy viscid fluid.
Treatment.—Three grammes of Antipyrin in water were injected subcu-
taneously with a temperature of 41.1°C. and the hæmatozoa swarming in the
blood, and a few hours later four grammes were administered by the mouth
with the effect that the temperature was only lowered two-fifths of a degree
Centigrade.
Horse No. XXIII.—Chestnut
Country-Bred Horse, aged. Subcuta-
neously inoculated on the 4th June 1891, with 1.0 c.c. of blood taken from the
heart of Horse No. XXI, 5-5 hours P.M. A tumor appeared at the seat of inocu-
lation which gradually increased in size and was accompanied by tension and
tenderness of the part until the sixth day, remained stationary until the ninth
day, when it was found to have diminished in size, &c, and the hæmatozoon pre-
sent in the blood. The latent period occupied eight days. The temperature
remained normal until the evening after the first appearance of the organism in the
blood. It then attained 40.2°C. on the second day of the disease, and from that
date until the 15th day took on the continued type with intermissions at irregular
periods, and from the latter date until death, which occurred on the 29th day,
the temperature oscillated, but seldom exceeded the maximum limit of the nor-
mal range. The chief point of pathological interest was the presence of sub-endo-
cardial ecchymoses in the left ventricle and their absence from the right.
B 1086—8