37
one Guinea-pig the hæmatozoon appeared in the blood in ten, and in the other
after an interval of fourteen days. Eventually death took place in the former
after fifty-eight days, and in the latter one hundred and thirty-nine days after
Inoculation.
The temperature steadily rose on the evening of the inoculation, and on
the sixth day the maximum observation during the whole course of the case
was registered, namely 41.9°C. The animal died on the 127th day after inocula-
tion ; a continued fever with more or less daily remissions and exacerbations
was present, but with these exceptions, on the morning of the 30th December
and on the 14th and 15th of April, the temperature never fell below 40°C. and
it was 40.9°C. at death.
Autopsy.—Body somewhat emaciated. Frothy fluid in the trachea. Loca-
lized emphysema at the apices of both lungs. Brain, vessels congested, and the
convolutions flattened. Both lateral ventricles contained fluid, the right much
larger, and contained more fluid than the left ; substance of right hemisphere
considerably thinned by the pressure of the contained fluid. Other organs
presented a healthy appearance.
Guinea-pig No. 1 (sheep).—Subcutaneously inoculated on the 24th January
1891, with 0.7c.c. of blood, from which the hæmatozoon was absent, removed from
Sheep No. 1. The latent period occupied ten days. The fever was of an intermittent
type during the first three weeks, but there was continued fever during the last five
weeks of the disease. Death occurred on 23rd March 1891, on the 49th day of the
disease.
Autopsy.—Body somewhat emaciated. Lungs general emphysema, a few
petechiæ dotted over the surfaces of the organs. Heart distended with firm clot,
presented numerous ecchymoses dotted over the surface of the organ, but lying
beneath the pericardium. Liver large. Kidneys the external cortical surfaces
(dotted over with small petechiæ. Spleen much enlarged, ten times normal size.
Bladder healthy.
Guinea-pig No. II (sheep).—Subcutaneously
inoculated as in case No. I.
The latent period occupied fourteen days. The fever was peculiar in this case
owing to the fact that it was present from the first day of the disease until
the morning of the tenth. From the evening of the tenth day until the morning
«of the twenty-first was occupied by an intermission, with normal and sub-normal
temperatures. Whilst from the 21st day to the one hundred and twenty-sixth
continued fever prevailed with only two occasions on which the temperature
touched 39°C. Death occurred on the 12th June 1891, the 126th of the disease.
Goat No. I.—Subcutaneously inoculated on 4th November 1890, with 0.5c.c.
of blood swarming with organisms, taken from the .Jugular Vein of Horse No. II
ante mortem.
The latent period occupied six clays. The temperature rose
from 40°C. on the day previous to, and registered 42.2°C. on the morning, when
the hæmatozoon first appeared in the blood. After this date the fever became
of the continued type with daily remissions and by intermissions at frequent
intervals during the first seventeen days, but from the latter date until death
on the 53rd clay, with the exception of one on the 43rd day, the intermissions
were entirely absent. Death occurred on 1st January 1891.
Autopsy.—Body
emaciated. Lungs.—Yellow-coloured
exudation at both
apices and superior surfaces ; the different lobes were more or less agglutinated
by lymph. Emphysema at the upper portions of the organs, right base deep
red in colour, and somewhat firm, but not consolidated. The cavity of the peri-
toneum contained some ten ounces of fluid. Omentum petechiated, especially
on the left side. Hydatid cyst attached. Spleen enlarged, perihepatitis.
Kidneys presented numerous calcareous bodies imbedded in the cortical portion.
Testicle.—One ounce of fluid drawn off from the right tunica vaginalis ; on
section the left testicle presented a localized patch, the seat of an inflammatory
change. Brain.—The cavity of the lateral ventricles much enlarged, forming
one end distended with fluid. Hemispheres only represented by a thin layer of
brain substance, an eighth of an inch in thickness.
Goat No. II.—On two successive days, May 9th and 10th, 1891, one cubic
centimetre of blood containing numerous hæmatozoa was given by the mouth,
B 1086—10