viii
November 30th.—Temp. A.M. 39.6°C. The animal appears dull, hanging his head this
morning ; appetite remains unimpaired. Hæmatozoa numerous in the blood. Temp. P.M. 40.6°C.
December 1st.—Temp. A.M. 39°C. In about the same condition as yesterday. The
hæmatozoa numerous in the blood. Temp. P.M. 39°C.
December 2nd.—The animal is very dull this morning and the appetite is capricious, the
gait is very unsteady and the œdema has increased. The pulse is hard, frequent and irritable.
Hæmatozoa numerous in the blood. Temp. P.M. 40°C.
December 3rd.—Temp. A.M. 38.8°C. The animal is still dull, but has improved very
slightly since yesterday. The appetite is fair but not normal, and the patient is daily growing
weaker. No hæmatozoa in the blood. Temp. P.M. 39.4°C.
December 4th.—Temp. A.M. 38.4°C. In about the same state as yesterday. No hæmatozoa
in the blood. Temp. P.M. 40°C.
December 5th.—Temp. A.M. 39°C. Is a little brighter this morning, but is very weak
and scarcely able to walk,about. No hæmatozoa in the blood. Temp. P.M. 39.7°C.
December 6th.—Temp. A.M. 39.9°C. No perceptible change in the animal's condition.
No hæmatozoa in the blood. Temp. P.M. 39.6°C.
December 7th.—Temp. A.M. 39.2°C. Animal getting weaker. No hæmatozoa in the blood.
Temp.P.M.39.3°C.
December 8th.—Temp. A.M. 39.7°C. The animal is very dull and weak this morning and
the appetite is bad. Hæmatozoa. few in the blood. Temp. P.M. 39.9°C.
December 9th.—Temp. A.M. 37.3°C. The animal is sinking, very dull, and scarcely
eating anything. He can hardly stand. The pulse is small, hard and frequent and the
heart beats are tumultuous,. The conjunctivæ are deeply petechiated. Hæmatozoa very
numerous in the blood. Temp, P.M. 37.6°C.
December 10th.—Temp. 37.6°C. The animal fell this morning at about 11 o'clock.
He exhibits extraordinary rigidity of the sterno-mastoids and the large muscles of the neck
and fore-limbs ; the fore-legs are extended and rigid, tetanic in character. Death took place
at 2-30 P.M.
AUTOPSY.—Immediately
after death. Body emaciated, both corneæ. opaque. The
hard nodule alluded to as present in the upper lip when examined is found to be a cyst with
fibrous walls, one-eighth of an inch in thickness, containing a viscid, glairy material resembling
white of egg. No hæmatozoa were found in this fluid on microscopical examination. The
pleural cavities contain no fluid. The lungs present localized patches of emphysema, but no
pneumonia. The heart is enormously distended with blood, and walls of the left ventricle
are considerably hypertrophied. Stomach contains a quantity of semi-fluid ingesta. One
localized patch of superficial congestion is noticed on the greater curvature. About two
inches from the boundary-line on the villous portion there are three raised nodules nearly
circular in form, from 1½" to 2" diameter, the greatest thickness being in the centre, and
gradually tapering to the edges. On section they are found to be loculated, the intervening
walls being of a white fibrous nature. These nodules contained " spiroptera
megastoma".
Spleen much increased in size. The surface is dotted over with small, brown circum
scribed extravasations.
Liver.—The only abnormality noticeable in the liver is the presence of numerous circum
scribed pearly-white bodies resembling tubercle. These bodies are scattered over the surface
oil the organ showing through Glisson's capsule and are also imbedded in the liver-tissue.
Kidneys.—Capsules adherent in places. On the surface of the right kidney is found
an oval red patch about ½" in length and ¼" in width and clipping into the cortical substance
to the extent of ⅓". Mesenteric glands. Considerably enlarged, very dark in colour and on
section presenting the appearance of splenic tissue.
Intestines.—Apparently healthy.
Bladder.—Apparently normal.
A quantity of blood was collected from the heart in this case ; after allowing it to stand,
the serum was pipetted off and passed through a porcelain filter. Different quantities, as
per notes, were injected subcutaneously into three Rabbits and two Guinea-pigs.
Remarks.—This animal was much stronger on its arrival at the Laboratory than the
other two. It had only been ill for about 16 days previous to its journey to Poona. During
the period it was under our observation, it passed through four relapses, taking the duration
of a relapse from the time when the hæmatozoa are absent from the blood through the
period during which they are numerous until they again disappear from the blood. The
first period during which the hæmatozoa were present lasted for eight days and was followed
by an interval of two days when they were absent. The second period lasted for seven days
and was followed by another interval of three days' absence. The third period lasted four
days only and was followed again by three days' interval. The fourth, period lasted six days
and was followed by a much longer interval, viz., five days, after which the hæmatozoa became
very numerous, but were much fewer before death occurred. The chief points of interest
in this case are :—
(i) The Urticarial form of eruption occurring between the second and third week after
the animal had been attacked with the disease.
(ii) The effusion of blood into the anterior chambers causing total blindness.