clx
AUTOPSY.-—Early on the morning of the 21st. The body is emaciated, and there
is considerable swelling and œdema of the under-surf ace of the belly lying between the skin
and the abdominal muscles and extending forwards between the fore-limbs up on to the chest,
and backwards to the sheath and scrotum. On section, a considerable quantity of jelly-like
material is found, of a sherry colour, somewhat firm at first, but on standing, serum runs
gradually from it.
On opening the thorax, about a pint of amber-coloured fluid is observed in each pleural
cavity, but there are no adhesions of the parietal and visceral pleuræ.
Right lung is dotted over its surface with numerous small ecchymoses and a few about
the size of a split-pea. These are dark in colour and on section are found to be lying below
the visceral pleura. The tissue of the lung on section presents a yellowish-red colour, is
distended with air and healthy.
Left lung.—The ecchymoses are fewer in number, otherwise this organ is in the same
condition as the right.
Heart weighs 4 lbs. .7 ozs. There are a few ounces of fluid in the cavity of the pericardium
dark yellow in colour. The external surface of this organ presents the same pathological
conditions found in most cases. The base is surrounded by orange-coloured jelly material in
lieu of the ordinary fat seen in temperate climates. The right ventricle has numerous small
extravasations lying under the visceral pericardium and a few running down the course on
either side of the anterior coronary vessels. The left ventricle is free from these ecchy-
moses. On section the right side of the heart contains numerous clots, which extend up
into the large vessels and are of an orange colour. There are a few eub-endocardial extra-
vasations, very small in the right auricle; but there are several more extensive ones in the
right ventricle. The valves are healthy. The left auricle is free from ecchymoses. The
left ventricle is contracted, the cavity very small and the walls thick and certainly hyper-
trophied. There are only a few ecchymoses lying under the endocardial lining and these
are small in size. The valves are not involved and are healthy.
Stomach.—Apparently healthy and normal.
Liver.—Weighs 12 lbs. 11 ozs. Old signs of inflammation of the capsule on its convex
surface, the right lobe presents numerous small yellow bodies, hard to the touch; the left
ditto, but fewer in number. On section the tissue looks dark, but healthy, and some few
concretions imbedded in the substance of the tissue, are easily enucleable.
Spleen.—Weighs 4 lbs. 2 ozs, Numerous ecchymoses on the surface. On section, the
tissue is firm and healthy looking.
Kidneys.—Right 1 lb. 10 ozs. Left 1 lb. 10½ ozs, In both, the capsules strip easily
and present a few purple spots, varying in size mostly about the size of a pin's head, which on
section are found to dip down into the cortical portion. Organs pale.
Small intestines, no patches of congestion or ecchymoses.
Large intestines, healthy; there are no parasites in the intestines.
Remarks.—This animal was under observation for a long period previous to inoculation,
viz., February 18th to May 3rd 1892, and being in fair condition and healthy was inoculat-
ed on May 3rd at 4 P.M.
A small swelling appeared at the seat of inoculation on the 6th May which gradually
increased in size and became very tense and tender to the touch. On the morning of the
8th there were no hæmatozoa in the blood on microscopical examination, but at 1 p.m,
the temperature rose to 39.1°C., and at 3 P.M. the tumor had become softer and less tense.
On examination of the blood a few hæmatozoa were then observed. The above-mentioned
rise in temperature was the commencement of a period of elevation and recrudescence which
lasted for three days. The highest point attained was 41.3°C., and on the morning of the
fourth day (12th) it fell to 39.4°C.; during the 10th and 11th the hæmatozoa were swarm-
ing in the blood and on the 12th became numerous. This appears to have been an abortive
attempt on the part of the temperature to become normal and for the hæmatozoa to dis-
appear from the bipod. During the next three days the temperature varied between 39.2°C.
and 40.8°C., the hæmatozoa again for one day being found swarming in the blood. For
the next three days the temperature remained below 40°C., except at mid-day, and the
hæmatozoa were few. On the morning of the 17th temperature nearly touched 38°C, but
again rose on the 18th to 41°C. and then gradually fell. The hæmatozoa were numerous and
on the 20th swarming and remained so until death which took place at 9-30 P.M.
The points to be observed in this case are :—
(i). The first appearance of the swelling at the seat of inoculation sixty hours
after the injection of blood containing hæmatozoa.
(ii). The increase in size of the tumor accompanied by tension and tenderness
until the morning of the 8th of May, when the tumor commenced to subside, became
less tense and tender.
(iii). The first appearance of the hæmatozoa in the animal's blood was on the fifth
day or 119 hours after the inoculation of blood from horse LVI1I.
(iv). The inoculated disease in this case was localized for 4 ½ days at the seat of
inoculation and did not become generalized until after mid-day on the 8th May.
(v). The possibility of adopting radical treatment in such cases during the period
elapsing between the inoculation of the virus and the first appearance of the hæma-
jozoon in the blood.