116
the morning of the second day registered 36.5°C, the animal presented a brighter appear
ance, and some further absorption of the exudation on the under-surface of the abdomen had
taken place, although that of the limbs continued unabated.
During the period which elapsed between the 11th of December 1892, and the 4th of
January 1893, the Arsenical treatment was continued ; the Surra hæmatozoon was absent
from the blood. The maximum dose of grains vii, was again exhibited on the 14th and 15th
December, but from the latter date it was gradually reduced by one grain at a time, until
the minimum of grains iii, was reached on the 3rd January. On the 16th December, the
animal commenced to lose flesh rapidly, although previous to that date it had become to a
certain extent emaciated within the limits of health. Prom this date, however, in spite of
the amount of food consumed, progressive atrophy of the muscles set in, especially along
either side of the spinal column and those surrounding the hip-joints and buttocks. The
œdema of the extremities and under-surface of the abdomen entirely disappeared, and as
before mentioned the girth of the animal's body just in a line with the sheath measured only
57 inches. No doubt, this can be readily accounted for by the condition of the kidneys, for
during a period of nearly five weeks, a large amount of albumen was found in the urine,
varying between ⅓ and 1/22 and on one occasion as low as 1/40. Blood, epithelial and granular
casts were present for the first eighteen days of the disease, and were followed by hæma
turia, varying in amount for twenty days, during which period no casts or crystals were dis
covered in the urine.
From the evening of the 3rd December 1892, until the evening of the 3rd of January
1893, three hundred and one grains of Arsenic, in the form of Liq. Arsenicalis were given in
the drinking water, and the hæmatozoon was absent from the blood for a period of twenty-
seven days.
Arsenic.
Case No. LXXVII.—This
animal, a Persian Gelding, aged 13 years, was admitted
into the Laboratory Hospital on the 29th November 1892, the
third day of the disease, with a temperature of 39.2°C., which
by midday had risen to 40.3°C., but again fell in the evening to 39.1°C., P. 56, R. 28. At
5-30 P.M. an eruption of Urticaria appeared, which gradually faded as the night advanced.
Treatment was commenced ou the morning of November 30th, the fourth day of the disease,
when Arsenic gr. iv. bis die, was prescribed. The urticarial eruption recurred each morning
but daily faded towards night, until December 3rd, the 7th day of the disease. On this latter
date the hæmatozoa, which had been present for the six previous days, disappeared from
the blood, but this was most probably only a phase of the disease, and simply the
commencement of a natural intermission, and not the effect of the twenty-six grains
of Arsenic, which had been given in the drinking water up to date. The dose of the
chemical was now increased to gr. vi. bis die, and was continued for two days, after
which it was decreased to gr. v. After an absence of three days, during which the
temperature oscillated between 39.3°C. and 37.C., P. 56 to 44, R. 20 to 12, the hæma
tozoon re-appeared in the blood, and a few were observed during the 10th and 11th days of
the disease. This, however, proved only an abortive attempt on the part of the organism to
return, for on the following day it was absent from the blood, thus proving that the Arsenio
was producing some effect. On the latter date, the dose was again increased to gr. vi, and
this was maintained until the evening of the 25th day of the disease. On the 26th and 27th
days it was decreased to gr. v, on the 28th day to gr. iv, from the 29th to 31st gr. iijss, and
from the 32nd to the 36th day inclusive, doses of gr. iij were given. After this, the even
ing dose on the latter, and the morning dose on the 37th day were omitted, owing to the
animal presenting a somewhat dull appearance, but the same dose was repeated on the
evening of the 37th day.
Up to this time the hæmatozoon had been absent from the blood for twenty-six days,
and during this period the temperature had for the greater part of the time been below
38°C., but on the 35th day it became slightly elevated, the maximum registered being
38.7°C. From the commencement of the treatment, 319 grains of Arsenic had been given
in the drinking water in 34 days, in doses varying from gr. iij to gr. vi bis die.
On the morning of January 3rd, 1893, the 38th day of the disease, the hæmatozoon
again made its reappearance in the blood, and although absent on the following morning was
again present on the two following days—the 40th and 41st. On the latter date the tempe-.
rature reached 40.1°C. at midday, the pulse and respirations however remained within normal
limits, but at 5T30 P.M. a fairly well marked eruption of Urticaria appeared over the neck,
shoulders, and was especially well marked over the inner side of the thighs, and perineal
region ; but it had completely faded on the morning of the following day.
From the 42nd, to the evening of the 56th day of the disease, the organism was again
absent from the blood ; the temperature oscillated between 40°C. and 37.8°C., the pulse and
respirations varying but little in frequency, and always keeping within the normal limits.
From the morning of the 38th to the evening of the 56th day, 200 grains of Arsenic were
given to the animal, in doses varying between grs. iij to grs. vi ss his die, but no bad
symptoms of any kind were observed, which could be attributed to the effect of the
chemical.