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Remarks.—This animal 11 years of age, four years in the country, suffered from fever
on 8th November 1892. The Surra hæmatozoon was discovered in the blood on 25th Nov
ember 1892. Received at the Laboratory Hospital on 26th November 1892. On its
admission the temperature was 39.2°C., P. 72. R. 12, and the blood contained a few
organisms. In this case it was determined to try the effect of Liq. Potassæ in large
doses on the hæmatozoon and as the temperature rose the same evening to 40°C., a dose of
drachms iv was administered. On the morning oil the 27th the temperature was 39.1°C., P. 76,
R. 20, and the hæmatozoon, absent from the blood, but by evening the temperature
had again risen to 397°C. P. 80, R. 24. Nine drachms of Liq. Potassæ were given during
the twenty-four hours. By the 28th, temperature, pulse and respirations had all fallen
considerably, but the organism had again made its appearance in the blood. The urine was
found to contain, in addition to albumen 1/22nd and casts, a trace of bile and bile acids. At 5
P.M. the temperature was 40.2°C. P. 72. R. 24. Three doses of medicine were administered
during the day. On the morning of the 29th, the animal presented a dull appearance and
there was a slight mucous discharge from the nose; the temperature had fallen a degree
during the night, but the pulse was dicrotic and registered the same as on the previous
evening and the hæmatozoa were few in the blood ; three doses of the medicine were
repeated. On the 30th, the animal again presented a dull appearance, the visible mucous
membranes were clean, but the conjunctiva petechiated; there was also considerable œdema
of the extremities, especially the hind limbs, and the sheath presented the same condition
but to a more limited extent.
Temperature A.M. 39.8°C. P. 72. R. 20. Hæmatozoa few in the blood. Three
doses of medicine were repeated. December 1st. —The animal looked brighter but the
disease continued to progress ; the visible mucous membranes were tinged yellow, and
the left conjunctiva invaded by five large petechia?. The pulse was regular but the beat
forcible, and jugular regurgitation was present. The hæmatozoon however was still pre
sent in the blood and the œdema of the sheath and extremities had increased in amount.
Owing to the presence of a denuded patch on the floor of the mouth from which the
mucous membrane had been accidentally removed whilst administering the medicine, it was
decided to omit any further doses of Liq. Potassæ until the abrasion had healed. Up to
this time the animal had received sixty-three drachms of Liq. Potassæ in thirteen doses,
equivalent to about 220 grains of Hydrate of Potassium ; the disease had continued to pro
gress during the administration of this chemical, but it had in no way disarranged the
organs of digestion, for the appetite is noted on this date as excellent. On the other hand
the albumen in the urine had steadily increased in amount during its exhibition, but it is
difficult to say to what extent, if any, the increase of albumen was due to the large doses
of Potash.
On December 2nd the temperature was 39.4°C. P. 72. R. 20. The hæmatozoa had
increased and were now numerous in the blood but the general condition of the animal was
unchanged. On the morning of the 3rd the temperature maintained the degree registered
on the previous evening, pulse 68, but the respirations had fallen to 16 per minute and the
organisms were still numerous in the blood. The pulse-beat was forcible and quick, but
regular. The œdema on the under-surface of the abdomen had extended forward and the
albumen in the urine had attained to ⅓rd, in addition there were numerous blood and
epithelial casts and a few pus cells. On experimentation the re-action for bile pigment was
well marked. In consequence of the unsatisfactory condition presented by the animal it was
decided not to recommence the administration of the Liq. Potassæ but to substitute Arsenic
for it, commencing with the full physiological dose of four grains to be repeated twice in the
twenty-four hours.
On the evening of the 3rd December, Temp. was 39.4°C. P. 72. R. 20. The first dose
of grains iv was given after the evening meal in the drinking water in the form of Liq.
Arsenicalis.
On the following morning the temperature was 39.2°C., the pulse remained
as before, but the respirations had increased to 24 per minute. The hæmatozoa were
few in the blood. The same dose of Arsenic was continued, making eight grains in all.
On the morning of the 5th, the temperature had fallen to 38.2°C., the pulse to 64, and
respirations 20, but the animal presented a dull appearance, and the general symptoms
of disease were intensified, but still the appetite remained excellent. There were a few
hæmatozoa in the blood. At 5 P.M. the same evening the pulse had again increased
in frequency and registered 76 per minute. Temp. 39°C. R. 24. Ten grains of Arsenic
were given during the day. On the morning of the 6th, the temperature bad fallen
half a degree, pulse 64, respirations 12, but the hæmatozoa were very numerous in the
blood. The same dose of Arsenic was continued. By the following morning the tem
perature had again fallen a degree, but the organism was still present in the blood,
although in small numbers. The animal continued to present a dull and semi-somnolent
appearance and the œdema had increased in amount between the fore-legs. In the evening
the thermometer registered two-thirds of a degree above the morning observation. Arsenic
increased to grains vi bis die. During the following night the temperature fell and at 8 A.M.
registered 37°C. in the rectum, the pulse was 60, respirations 12. There were a few hæma-
tozoa
under-surface of the abdomen was slightly reduced in amount. The temperature however