xlvi
Guinea-pigs were inoculated at 4 P.M. with 0.2 c.c„ 0.25 c.c. and 0.3 C.C, respectively oil
blood drawn from the Jugular Vein in order to ascertain whether it possessed the power oil
reproducing the disease. Temp. 5 P.M. 40.4°C. P. 64. E. 12. Two doses of the medicine
were administered during the twenty-four hours.
12th.—This morning, at 8 o'clock, the eruption of Urticaria was well marked, presenting
large patches on the flanks and abdomen, which gradually faded and by mid-day was hardly
perceptible. The visible mucous membranes present a dirty, dusky appearance and there
are several fresh petechias on the conjunctivæ. The appetite remains good and the fæces
normal in character. Temp. A.M. 38.4°C. P. 52. R. 12. The hæmatozoon is absent from the
blood. Temp. 1 P.M. 38.5°C. Urine, turbid, viscid, orange in colour, Sp. Gr. 1,018
alkaline, contains albumen 1/11th, crystals of. Carbonates and Oxalates.
Two doses of
the medicine were administered during the twenty-four hours of gr. x in all. Temp. 5 P.M.
38.5°C. P. 52. R. 16.
14th.—There is no sign of the eruption this morning; the animal appears bright, the
visible mucous membranes are cleaner than yesterday and there are no fresh petechiæ
present. The appetite is good and the fæces normal in character. Temp. A.M. 38.1°C.
P. 64, R. 12. The hæmatozoon is absent from the blood. Temp. 1 P.M. 38.4°C. Urine,
turbid, yellowish-brown, Sp. Gr. 1,028, alkaline, albumen 1/23rd; contains Carbonates
and Oxalates of Calcium. Two doses of the medicine were administered during the
twenty-four hours. Temp. 5 P.M. 38.2°C. P. 52. R. 16.
15th.—This morning the animal looks bright and it would be difficult to say that it
was suffering from any disease. The visible mucous membranes are clean and the petechiæ
absent from the conjunctivæ. There is no sign of oedema or swelling of the extremities or
abdomen. The pulse is full but regular, the appetite very good and excretions normal in
character. Temp. A.M. 38.2°C. P. 48. R. 12. The hæmatozoon has again appeared in
the blood in small numbers (few). Temp. 1 P.M. 38.3°C. No urine was passed during the
day. Two doses of the medicine were administered during the twenty-four hours. Temp.
5 P.M. 39.4°C. P. 60. R. 16.
16th.— The temperature has suddenly become elevated, 40.7°C, but the animal appears
quite as well as it did yesterday. The pulse is frequent, strong, but regular— 64, and the
respirations tranquil—12. The hæmatozoa, however, are numerous in the blood. Temp.
1 P.M. 40.8°C. Urine, turbid, orange, Sp. Gr. 1,034, alkaline, contains albumen 1/16th
together with crystals of Carbonate and Oxalate of Calcium.
One dose of Iodic
Hydrarg : gr. vi, was given in the morning, but in the evening, as the temperature became
elevated, three drachms of Quinine were administered. Temp. 5 P.M. 4l.7 o C. P, 64
R. 16.
17th.—The temperature, which had attained such a height last evening, fell during the-
night to 2.7°C. and the animal appears bright and walks freely about its box. The visible
mucous membranes are tinged with yellow but there are no fresh petechias on the conjunc-
tivas; the pulse is full and strong but markedly dicrotous. There is now no swelling or
œdema of the limbs or of the sheath. Appetite good. Temp. A.M.. 39°C. P. 68. R. 12.
The hæmatozoon is absent from the blood. Temp. 1 P.M. 39°C. Urine, clear, orange,
Sp. Gr. 1,017, neutral, albumen 1/24th, crystal's of Carbonate and Oxalate of Calcium. Two
doses of medicine were administered during the twenty-four hours, the latter consist-
ing of Iodic Hydrarg : gr. vi. Quinæ Sulph. 3i. Temp. 5 P.M._39°C. P. 56. R. 24.
18th.—'The animal presents a very satisfactory appearance, and has improved in every
way. Temp. A.M. 37.3°C. P. 52. R. 12. The hæmatozoon is absent from the blood. The
red corpuscles form healthy rouleaux and the white are not increased in number. Temp.
1 P.M. 38°C. Urine, turbid, viscid, orange in colour, Sp. Gr. 1,024, alkaline, contains
albumen 1/24th, crystals of Carbonate and Oxalate of Calcium. The animal received two
doses of Iodic Hydrarg: gr. vi and Quinæ Sulph. 3i on each occasion. Temp. 5 P.M. 38.6°C
P. 52. R. 16.
19th. -The animal has developed a slight cough this morning, but otherwise presents
the same appearance as yesterday. Temp. A.M. 38.l°C. P. 48. R. 12. The hæmatozoon
is absent from the blood. Temp. 1 P.M. 38.2°C. Urine, turbid, viscid, orange in colour
So. Gr. 1,022, acid and contains albumen 1/20th, crystals of Carbonate and Oxalate Calcium
Two doses of Iodic Hydraig, each consisting of gr. vi, together with Quinæ Sulph. 3i, were
administered during the day. Temp. 5 P.M. 38.3°C. P. 56. R. 16.
20th.-The cough still continues, but only at long intervals and does not appear
to distress the animal. The general condition is unchanged, the mucous membranes are clean
and free from petechias, there is no swelling of the extremities or of the under-surface of the
abdomen. The appetite is good and the evacuations normal. Temp. A.M. 38.l°C. P 56.
R,. 16. The hæmatozoon is absent from the blood. Temp. 1 P.M. 37°C. Urine, turbid,
viscid, bright-yellow in colour, Sp. Gr. 1,046, alkaline and contains albumen 1/18 th ; crystals
of Carbonate and Oxalate of Calcium. Two doses of medicine were administered during the
twenty-four hours, Iodic Hydrarg: gr. vi in the morning and Quinæ Sulph. 3vi at night.
Temp. 5 P.M. 38.5°C. P. 52. R. 20.