NationalLibraryOfScotland/medical-history-of-british-india huggingface dataset:
cxxiv
October 2nd.-
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„ 3lst
November 1st
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3rd
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4th
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5th
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7th
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8th
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9th
-Temp.
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A.M. 36.8°C. NOON
„ 37.2°C.
„ 37.6°C.
„ 37°C.
„ 371°C.
„ 37.7°C.
„ 37.8°C.
„ 37.3°C.
„ 37.1°C.
„ 37.1°C.
„ 37.5°C.
„ 36.6°C.
„ 36.8°C.
„ 37°C.
„ 36.6°C.
„ 367°C.
„ 36.2°C.
„ 37.2°C.
„ 37.3°C.
„ 36.4°C.
„ 37.1°C.
„ 37.3°C.
„ 37.1°C.
„ 37.8°C.
„ 36.8°C.
„ 37.5°C.
„ 38.2°C.
„ 37.8°C.
„ 37.8°C.
„ 37.7°C.
„ 38.2°C.
„ 37.2°C.
„ 36.7°C.
„ 38.1°C.
„ 37.3°C.
„ 37.6°C.
„ 39.3°C.
„ 39.l°C.
„ 39.7°C.
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36.7°C.
38.2°C.
38.1°C.
37.7°C.
37.6°C.
38°C.
38°C.
38°C.
38°C.
38°C.
37.5°C.
37.8°C.
37.6°C.
37.4°C.
37.2°C.
38°C.
38.3°C.
38.3°C.
37.2°C.
38.1°C.
38°C.
38.3°C.
38.6°C.
38.8°C.
38.2°C.
38.4°C.
38.4°C.
38.5°C.
38.8°C.
38.6°C.
38.2°C.
37.5°C.
37.6°C.
38.l°C.
38.3°C.
38.8°C.
39.6°C.
39.2°C.
P.M.
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Death 11 A. M.
37.5°C. :
37.6°C.
38°C.
37.4°C.
38.5°C.
38.3°C.
38.3°C.
37.8°C.
38.3°C.
38.3°C.
37.8°C.
37.4°C.
37.4°C.
38.2°C.
37.7°C.
38°C.
37.8°C.
38.3°C.
38.2°C.
38°C.
38.1°C.
38.2°C.
38.4°C.
38.3°C.
38.4°C.
37.6°C.
38°C.
38.2°C.
38.6°C.
38.2°C.
38.3°C.
38.3°C.
37.8°C.
38.8°C.
392°C.
39.2°C.
39.4°C.
No hæmatozoa in the blood.
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AUTOPSY.—1-30 P. M.
The body is somewhat emaciated.
Thorax.—There is no fluid in the pleural cavities and there are no adhesions.
Right Lung.—The apex is dark in colour and is the seat of well marked emphysema.
several of the emphysematous blebs being as large as small walnuts and filled with blood-
stained serum. There is a localized patch in the centre of the anterior lobe which is conso-
lidated ; and on section the lobules are found to be divided off individually or in small groups.
as in Pleuro-pneumonia of cattle. by a layer of light lemon-coloured exudation. This
condition is localized to an area 5" x 5". The pleural covering on the superior surface of the
organ is thickened and somewhat white in colour. due to old inflammatory changes ; but the
tissue presents a healthy appearance.
Left Lung.—The apex and free edges are the seat of localized emphysema. and the pleura
covering the superior surface is thickened and presents the same changes as observed in the
right. On section. the tissues are healthy.
Heart.—Weighs 4 lbs., externally the organ presents a healthy appearance. On section.
the cavities are full of semi-fluid blood. There were no ecchymoses or extravasations of any
kind under the endocardial lining. The valves are healthy.
Liver.—Is dark in colour and weighs 8 lbs. and 11 ozs. The surface of the organ is
dotted over with small yellow concretions which are found to pervade the substance of the
organ on section.
RECORDS OF TEMPERATURE, PULSE AND RESPIRATION,
APPENDIX III.
EXPERIMENTAL CASES.
DIRECT INJECTION OF BLOOD INTO THE JUGULAB VEIN
HORSES XIV, XV.
cxxx
There, are a few extravasations in the right ventricle lying beneath the endocardium; but
in the left ventricle/there are many and extensive extravasations of blood. The largest
involve for the most part the musculi-papillares.
The small intestines.—Present a few petechiæ dotted over the surface of the gut; but
there is no ulceration.
The Cæcum and Colon.—Are full of green fæcal matter, but on careful examination no
petechiæ are visible.
Remarks.—On the 31st January, the day following the direct injection of Surra blood
into the internal Jugular Vein, the temperature rose rapidly to 40.l°C. and continued high
all that and the next day until the evening when it suddenly commenced to fall, and by the
morning of the 3rd February, it had fallen nearly 3.5°C. and was as low as 36.2°C. The
same evening it again rose 2.5°C. and continued to rise for the next three days when it
attained the same height that it had previously done during the period of incubation. The
temperature did not again touch the same degree during the 20 days that the animal lived.
There was only one day, the 9th, after the appearance of the organism, on which the
hæmatozoon was absent from the blood during the whole course of the disease, but on
several occasions, abortive attempts were made to disappear. The chief points of interest in
this case are:—
(i). That the animal was directly inoculated with blood containing hæmatozoa
into the general circulation, and contracted the disease after an incubation-period
lasting less than five days.
(ii). That a great rise in temperature occurred on the 2nd day after inoculation
lasting until the evening of the 4th and was followed by a sudden fall on the mornino-
of the 5 th day.
(iii). That the hæmatozoon was only absent from the blood for 24 hours during
the period of 22 days.
(iv). That the injection of Oleum Terebinthinse had no effect in destroying or
reducing the number of hæmatozoa in the blood.
APPENDIX IV.
EXPERIMENTAL CASES.
SUBCUTANEOUS INOCULATION WITH ANTE-MORTEM BLOOD.
HORSES V, VIII, VI, XXII, IV, XXX, XXI, XXIX, LXIV,
LIX, LIV, LV, XXIV.
cxxxix
one, it was decided to try the effect of Iodoform and Æther. Accordingly on the 30th
instant, the hæmatozoa being absent, three grains of Iodoform in Æther were injected sub-
cutaneously, and again on the 31st, 4 grains of Iodoform in Æther. On the 1st January, 5
grains were injected directly into the Jugular Vein. On the 2nd, 14 grains, and on the 3rd
25 grains. On the 4th, the Iodoform and Æther having had no effect upon the hæmatozoon
in the blood, 0.6 gramme of Mercuric Perchloride was directly injected into the general cir-
culation. The action of the medicine had a marked effect upon the animal; but the hæma-
tozoa, after being few in the blood for 3 days and absent during 24 hours, again became
numerous, and remained so until the animal's death. The animal did not rally from the
effect of the medicine; but the hæmatozoa were apparently unaffected by it. Death occur-
red on the 10th January. The points of interest in this case are : —
(i). The presence of the hæmatozoon at the seat of inoculation three days after in-
oculation and two days before its appearance in the general circulation.
(ii). The fact that Iodoform given in sufficiently large doses by intra-venous injec-
tion to have a serious effect on the animal's health, had no appreciable effect on the
hæmatozoa.
(iii). The same may be said concerning the Mercuric Perchloride given in a large
dose.
cxliii
The right auricle and ventricle Contain dark coloured clots, but there are no sub-endo-
cardial extravasations. The left auricle is empty, and the left ventricle is contracted, and in
these cavities also the extravasations are absent. The valves appear normal.
Spleen is large, the surface is studded over with raised petechiæ, which present a dark
brick red colour. On the superior border there is some lymph, the result of recent inflam-
mation.
Kidneys. Right.—The capsule is stripped with difficulty, and reveals numerous small
round red coloured spots, which are dotted over the whole cortical portion of the organ. The
organ is otherwise pale, and on section, the tissues appear somewhat friable, but the petechia?
observed on the surface are not found to dip into the structure of the organ.
Left presents exactly the same conditions.
Liver, large, the seat of old perihepatitis, especially the surface of the left lobe. On sec-
tion the tissues are dark in colour, friable and are easily ruptured. The whole surface of the
organ presents a dotted appearance due to the presence of small circumscribed yellow
coloured bodies, hard and gritty to the touch, many of which lie immediately under Glisson's
capsule, whilst others are observed in the substance of the gland on section.
Stomach.—On section the organ is empty. On the surface of the mucous membrane
covering the greater curvature, there are several small extravasations of blood, which appear
to be lying almost on the surface of the membrane. The m. m. at the pyloric orifice of the
stomach is thickened, and there are several extravasations on the free surface of the mucous
membrane, as well as underneath it.
Intestines.—There are a few petechias dotted over the surface of the small intestine,
but they are circumscribed and lie far apart. There are no ulcers and no parasites.
Large intestine presents no change.
The points of interest in this case are :—
(i). The successful transmission of the disease by the subcutaneous injection of
1 c.c. of blood which contained very numerous hæmatozoa at the time of inoculation.
(ii). The period which elapsed between the inoculation and the appearance of the
hæmatozoon in the blood, was five days.
(iii). That the exhibition of Mercuric Perchloride subcutaneously had a disastrous
effect on the animal and very little on the hæmatozoon.
(iv). The presence of an Urticarial form of eruption, covering the neck and body
generally, but not very well marked; on the tenth day following the appearance of
the hæmatozoon in the blood and the sixteenth from the time of inoculation.
(v). The injection of a solution of Iodine and Iodide of Potassium had to be dis-
continued as it appeared to have no action on the hæmatozoon and produced a
serious effect on the animal.
(vi). The period between the inoculation and the death of the animal was 49 days.
(vii). The pathological lesions found at the Post-mortem examination, were of a
slight nature.
cxlviii
Kidneys.—The right weighs 1 lb. 5 ozs. The left 1 lb. 5 ozs. The capsules strip easily,
and disclose numerous small patches of extravasation, lying under the capsule on the cortical
portion, together with numerous injected stellate veins.
On section the tissues appear somewhat pale, but the extravasations do not invade the
underlying tissues.
Small intestines.—Present a healthy appearance, as also the large bowel.
This animal was only inoculated in order to keep up the supply of material.
The points of interest are :-—
(i) The successful transmission of the disease by the injection of 1 c.c. blood
containing a few hæmatozoa at the time of inoculation.
(ii). The time which elapsed between the inoculation of the blood and the first ap-
pearance of the hæmatozoon in the blood was seven days.
(iii). The short period which elapsed between the first appearance of the hæmato-
zoon in the blood and death, viz., one day.
(iv). The pathological lesions involving the lungs, heart and stomach.
HORSE
NO.XXI.
SHEWING THE SWOLLEN AND ŒDEMATOUS CONDITION OF THE EXTREMITIES, SHEATH AND UNDER SURFACE OF THE ABDOMEN,
ON THE 19TH DAY OF THE DISEASE.
cli
black clots ; there are no ecchymoses in the auricle or the ventricle. The valves are healthy.
The left side of the heart is contracted, the auricle is healthy. The ventricular walls are
hypertrophied. The auriculo-ventricular valves present two circular patches of extrava-
sated blood, purple in colour, one in each of two of the valves, about the size of a four-anna
piece. There is some decolorized clot in the left ventricle, but there are no ecchymoses of
any kind to be seen lying under the endocardial lining or on the musculi-papillares. The
aortic valves are healthy.
Stomach. — Contains some semi-digested food. On section, the cuticular portion is pale,
presenting a healthy appearance, whilst the villous is of a dark plum colour; the mucous
membrane is much thickened, but there is no sign of any ulceration or abrasion of the lining
membrane.
Liver.—Is very large and dark in colour. Glisson's capsule is almost invisible. This
is the only liver seen by us up to the present in Surra horses in which perihepatitis of the
left lobe was not more or less well marked. There are a number of circular opalescent
patches 1/12th of an inch in diameter with a central yellow minute speck. These are found
to lie under the capsule, but do not involve the structure of the organ. In the centre
of the anterior surface of the left lobe, a yellow mass ½ inch in diameter is seen which
runs through to the opposite surface. It is very hard in consistency and on section is found
to be externally formed of a thick incrustation of calcareous material, whilst the interior
is filled with a yellow coloured cheesy material.
Spleen.—There are several old cicatrices visible on the surface due to previous injuries.
There are no ecchymoses on the capsule, and on section, the tissue appears normal in
structure.
Kidneys.—Large and pale; the capsules strip easily. There are several small, round
dark, purple coloured ecchymoses dotted over the surfaces of both organs, at some consi-
derable distance apart, and on section, they are found not to invade the cortical structure.
Small intestines.—Contain some few patches of ecchymoses, but there is no ulceration.
Large intestines.—Healthy.
The points of interest are :—
(i). The successful transmission of the disease by the inoculation of 1 cc. of blood
from the internal Jugular Vein of an animal, from which the hæmatozoon was absent
at the time of inoculation.
(ii). The period of incubation, i. e., the time which elapsed between the inoculation
and the first appearance of the hæmatozoon in the blood was eight days.
(iii). The extraordinary quantity of semi-solid exudation into the subcutaneous
tissues of the most dependent part of the abdominal wall and extremities.
(iv). The occurrence of Epistaxis towards the termination of the disease.
(v). That after the administration of three doses of Sodii Salicylas amounting to
twelve grammes (3iij) the temperature should have steadily continued to rise.
(vi). The period which elapsed between the inoculation of the animal and its death
was thirty-six days.
(vii). The very slight pathological lesions found at the Post mortem examination.
clii
CASE No. XXIX-BROWN ARAB ENTIRE HORSE, aged, in fair condition and
apparently healthy.
bill July.— Temp. P.M. 36°C. Blood healthy.
6th.—Temp. A.M. 36.2°C. Blood healthy. Temp. P.M. 36.4°C.
7th.— Temp. A.M. 36.5°C. 11 A.M. Inoculated subcutaneously over the left shoulder,
with .8 c.c. of blood containing a few hæmatozoa taken from the internal Jugular Vein of
horse No. XXIII. Temp. p.m. 37°C.
8th.— Temp. A.M. 35.5°0.
9th.—Temp. A.M. 35.6°C.
10th.—Temp. A.M. 36.3°C.
11th—Temp. A.M. 35.8°C.
12th.-Temp. A.M. 36.2 C.
No hæmatozoa in the blood.
No hæmatozoa in the blood.
No hæmatozoa in the blood.
No hæmatozoa in the blood.
No hæmatozoa in the blood.
Temp. P.M. 35.8°C.
Temp. P.M. 36°C.
Temp. P.M. 37°C.
Temp. P.M. 36.7°C.
Temp. P.M. 37.8°C.
I3th. — The swelling and oedema at the seat of inoculation measures 2.5" x 1.5". Temp.
a.m. 36.l°C. No hæmatozoa in the blood. Temp. p.m. 37.7°C.
14th. —Right testicle is swollen. There is some fluid in the right Tunica Vaginalis.
Temp. a.m. 36.6°C. Hæmatozoa few in the blood in the morning, but numerous in the
evening. Temp. p.m. 39.5°C.
15th. —Temp. a.m. 38,3°C. Hæmatozoa very numerous in the blood. Temp. p.m.
39.3°C.
16th. -The right testicle has somewhat increased in size, but it is not painful on mani-
pulation. Temp. a.m. 37.3°C. Hæmatozoa very numerous in the blood. Temp. P.M. 38°C.
17th.— The swelling and oedema at the seat of inoculation is disappearing. There
is no tenderness now present. The conjunctivae are tinged a yellow colour, and there are
some small extravasations in the left nostril. The mucous membrane over the right lower
turbinated bone is very congested and dark-red in colour. Both testicles are swollen. Temp.
a.m. 37.4°C. There are very numerous hæmatozoa in the blood. Temp. P.M. 38.1°C. At
6 P.M. the animal is much weaker and has some difficulty in standing.
18th.—Temp. A.M. 36.5°C. Hæmatozoa swarming in the blood. At 2 A.M.. the animal
fell and remained lying quietly until 8 A.M. The animal was then lying with its front legs
rigid. The breathing was laboured, 20 respirations per minute.
Temp, at 2-30 P.M. 40.7°C. R. 80.
„
„ 3-30 „ 40.3°C. „ 84.
Death took place at 7-30 P.M.
AUTOPSY.-19th at 9 A.M.
Decomposition too far advanced for satisfactory examination. The portion of skin at
the seat of inoculation was excised shortly after death and placed in alcohol for further
examination. The points of interest in this case are :—
(i). The successful transmission of the disease by the inoculation of .8 c.c. of blood
containing a few hæmatozoa, from the Internal Jugular Vein.
(ii). The period of incubation, i.e., the time elapsing between the inoculation and
the first appearance of the hæmatozoon was seven days.
(iii). The short period which elapsed between the appearance of the hæmatozoon
in the blood and death, viz., four days.
cliii
CASE No. LXIV.—GREY, COUNTRY-BRED PONY, in fair condition and healthy,
aged.
2nd June
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14th
1892.-
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-Temp. P.M. 39.4°C.
A.M. 36.4°C.
5 P.M.38.1°C.
A.M. 36.7°C.
P.M. 38.l°C.
A.M. 36.7°C.
P.M. 37.5°C.
A.M. 36.3°C.
P.M. 37.5°C.
A.M. 37.6°C.
P.M. 38°C.
A.M. 37.6°C.
P.M. 37.6°C.
A.M. 36°C.
P.M. 38°C.
A.M. 37.6°C.
P.M. 38°C.
A.M. 35.3°C.
P.M. 88°C.
A.M. 36.4°C.
P.M. 38°C.
A.M. 37.5°C.
P.M. 38.6°C.
A.M. 36.7°C.
P.
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36
36
36
40
36
40
44
36
36
36
40
36
32
32
44
36
40
36
36
36
40
44
36
33
R.
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18.
13.
20.
16.
20.
12.
20.
16.
28.
12.
16.
16.
12.
12.
16.
12.
12.
12.
14.
12.
20.
20.
36.
15.
Inoculated this animal subcutaneously on the left shoulder with 5 c.c. of blood from
the left Jugular Vein of horse No. LXV (Surra naturally acquired).
Temp. 1 P.M. 39.2°C. Temp. 5 P.M. 39.6°C. P. 40. R. 32.
15th.—The animal appears in the same condition as yesterday, there is no swelling
at the seat of inoculation.
Temp. A.M. 36.8°C. P. 36. R. 24.
There are no hæmatozoa in the blood. Temp. 1 P.M. 38.6°C.
Temp. 5 P.M. 39.3°C. P. 42. R. 32.
16th.-—The condition of the animal is unchanged, there is a small swelling about the
size of a marble at the seat of inoculation.
Temp. A.M. 36.8°C. P. 32. R. 14.
There are no hæmatozoa in the blood.
Temp. 1 P.M. 39.3°C.
„ 5 P.M.38.5°C. P. 52. R. 20.
17th.—The animal looks well, appetite good, the membranes are clear and of normal
colour and the evacuations normal.
Temp. A.M. 37.4°C. P. 36. R. 14.
There are no hæmatozoa in the blood. Temp. 1 P.M. 38°C.
Urine.—Yellowish in colour, opaque, Sp. Gr. 1,020, alkaline; large numbers of striated
spheres of Carbonate of Lime stained a deep yellow colour, no albumen. Temp. 5 P.M. 38°C.
P. 40. R. 16.
18th.—The condition of the animal is unchanged. The swelling at the seat of inoculation
has increased in size and is now 2" x1.5" and is tender on manipulation. Temp. A.M. 37.4°C.
P. 32. R. 10.
There are no hæmatozoa in the blood. Temp. 1 P.M. 38°C.
Urine.—Opaque, orange in colour, Sp. Gr. 1,026, no albumen. Temp. 5 P.M. 38.1°C.
P. 40. R. 20.
19th.—The animal's condition is as yesterday, with this exception that the swelling is
somewhat larger. Evacuations normal. Temp. A.M. 36.8°C, P. 36. R. 20.
B 1086—39 ap
cliv
There are no hæmatozoa in the blood and nothing abnormal to notice. Temp, 1 P.M.
38.5°C. The urine is orange-coloured, muddy, Sp. Gr. 1,030, alkaline.
Temp. 5 P.M. 38.3ºC. P. 40. R. 20.
20th.—The tumor at the seat of inoculation has increased in size and now is somewhat
ovoid in shape, the long diameter measuring 3", the short a little over 1.75". The swelling is
tense and tender on manipulation.
Temp. A.M. 36.7°C. P. 36. R. 12.
There are no hæmatozoa in the blood.
Temp. 1 P.M. 39.1°C.
The urine is yellowish-red in colour, opaque, Sp. Gr. 1,018, alkaline, no albumen, but
numerous crystals of Calcium Carbonate. Temp. 5 P.M. 38.3°C. P. 40. R. 18.
21st—This morning the animal appears somewhat dull, but the appetite is good,
there are a few small petechias on the conjunctivæ; the evacuations are normal in character.
The swelling at the seat of inoculation is soft this morning, the tenseness having passed
away.
Temp. A.M. 37.6°C. P. 39. R. 12.
The hæmatozoa are very numerous and active, but rather small in size.
Temp. 1 P.M. 40°C.
The urine is opaque, yellow in colour, Sp. Gr. 1,023, alkaline, no albumen.
Temp. 5 P.M. 40.3°C. P. 40. R. 16.
22nd.—The animal appears very much as yesterday, but the swelling at the seat
of inoculation is smaller. The pulse is more frequent, the appetite remains good. Temp
A.M. 39.7°C. P. 64. R. 14.
'
The hæmatozoa are very numerous in the blood. Temp. 1 P.M. 40.4°C.
Uuine.—Sp. Gr. 1,038. Is opaque or cloudy, yellow in colour, alkaline.
Temp. 5 P.M. 40°C. P. 60. R. 20.
23rd.—The animal is very dull this morning, and there are numerous petechiæ on the
membranæ nictitantes of both eyes. The appetite is not quite so good as before, but the
animal continues to eat slowly.
Temp. A.M. 40°C. P. 60. R. 20.
The hæmatozoa are very numerous in the blood. Temp. 1 P.M. 40.7°C.
Urine.—Tarbid, yellow in colour, Sp. Gr. 1,030, alkaline, no albumen.
Temp.5 P.M.40°C. P. 56. R. 16.
24th.—The animal is in the same condition.
Temp. A.M. 39.7°C. P. 48. R. 16.
The hæmatozoa are swarming in the blood. Temp. 1 P.M. 41.1°C. The urine is
turbid, yellowish-red in colour. Sp. Gr. 1,032, alkaline. Temp. 5 P.M. 41°C. P. 64
R. 16.
25th.—The animal is somewhat brighter this morning, the appetite good, the eva-
cuations normal and the petechiæ are becoming fainter in colour.
Temp. A.M. 39.4°C. P. 56. R. 16.
The urine is turbid, orange in colour. Sp. Gr. 1,026, alkaline, no albumen.
Temp. 1 P.M. 40.7°C. The hæmatozoa are very numerous in the blood.
Temp. 5 P.M. 41°C. P. 68. R. 16.
26th.—The animal continues bright, the temperature has fallen a degree and a half
during the night.
Temp. A.M. 39.5°C. P. 60. R. 16.
The hæmatozoa are numerous.
Temp. 1 P.M. 40.8°C.
The urine is turbid, orange in colour, Sp. Gr. 1,018, alkaline, no albumen, numerous
crystals of Calcium Carbonate.
Temp. 5 P.M. 41.1°C. P. 64. R. 16.
27th.—No change in the condition of the animal, appetite good, evacuations normal
Temp. A.M. 39.1°C. P. 52. R. 14.
The hæmatozoa are numerous in the blood. Temp. 1 P.M. 40.7°C.
Urine.—-Turbid, yellow in colour, Sp. Gr. 1,016, alkaline, no albumen. Temp. 5 P.M.
40.4°C. P. 72. R. 32.