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Autopsy.—Body fairly well nourished, oedema of the extremities and under-
surface of the abdomen and front of sternum. Thorax.—No fluid in pleural
cavities or adhesions of the pleuræ. Lungs presented a few extensive, sub-pleural
extravasations ; emphysema at the apices. On section-—Tissues œdematous.
Pericardial cavity contained 6 ozs. of a turbid, amber-coloured fluid. Heart—
Enlarged ; weighed 6 lbs. ¾ oz. No sub-pericardial petechias. On section—Right
side blood-stained, no sub-endocardial extravasations noticeable. Left side—Con-
tracted. Presented a few sub-endocardial extravasations, principally on the
bases of the musculi-papillares. Liver—Small, weighs 9 lbs. 12½ ozs; old signs
of perihepatitis. On section—Tissue appeared healthy. Spleen—Enlarged,
weighed 2 lbs. 6 ozs ; sub-capsular petechiæ. Tissue, firm. Kidneys—Right
weighed 1 lb. 8 ozs. Left, 1 lb. 6½ ozs. On section presented a healthy ap-
pearance. Stomach—Fairly large. Cuticular portion healthy. Villous portion
stained yellow. Mucous membrane presented a healthy appearance.
PART II.
EXPEEIMENTAL CASES.
Horse No. IV.—Grey C. B. gelding, aged 15 years. Subcutaneously
inoculated on 8th November 1890 with 1.0 C.C. of blood taken from the Jugular
Vein of Horse No. III ante-mortem. The latent period occupied eight days.
The fever which was of a remittent type began to rise on the day previous to
the appearance of the organism in the blood of the general circulation and was
characterized by morning remissions and evening exacerbations, reaching a maxi-
mum of 41°C. on the evening of the fourth day of the disease ; for the next three
days the temperature touched 40.6°C. each evening and was followed by remis-
sions of 2°C. each morning; an intermission lasting two days then occurred, fol-
lowed by seven days of continued fever, and death occurred on the 2nd December,
the 17th day of the disease.
Horse No. V.—Bay C. B. horse, aged. Inoculated subcutaneously on the
18th November 1890 with 3.0 c.c. of blood taken from the Jugular Vein of horse
No. IV during life. The latent period occupied four days and was marked by
exacerbations and morning remissions in the temperature until the day upon
which the hæmatozoon appeared in the blood, when it rose to 39.6°C and then
gradually fell to 36.8°C in the next thirty-six hours, a rise occurring up to death
on the fourth day of the disease.
Autopsy.—A small circumscribed patch of pneumonia involving the apex,
and another the size of a walnut lying superficially in the posterior lobe of the
right lung, also a sub-pleural extravasation of blood. Pigmented condition of
cuticular and congested state of the villous portion of the stomach.
Horse No. VI.—Grey Persian, aged. Inoculated subcutaneously on the
22nd November 1890 with 1.0 c.c. of blood taken from the Jugular Vein
of Horse No. IV. The latent period was five days. On the day following the
injection of blood, no change had taken place, but on the morning of the third
day a small raised tumor, one inch in diameter, was apparent. This increased
in size until the evening of the fifth day when it remained stationary for a few
hours and then a loss of tension and tenderness of the part was observed to-
gether with the discovery of the organism in the blood on microscopical ex-
amination. On the morning of the twelfth day of the disease an eruption of
Urticaria appeared involving the skin of the whole body. Temperature on the
evening before 40.2°C.; but on the morning of the eruption was 37.8°C. The
organisms were numerous in the blood on the day prior to, few during the per-
sistence of the rash, and numerous again on the day following the eruption.
This case lasted for forty-five days and during that period assumed the continued
type of fever marked by remissions and one intermission on the 7th and 8th days
of the disease.
Autopsy.—Localized emphysema of the apices of the lungs, surfaces dot-
ted over with sub-pleural extravasations of blood. The heart presented sub-
pericardial extravasations, but no sub-endocardial were observed. There were
B 1086—7