ccxxviii
purulent material from the right nostril. The hæmatozoon was absent from the nasal
fluid, but present in that drawn from tunica vaginalis on the same date. It continued
however to be absent from the blood. On the 105th day after the re-inoculation, the animal
presented symptoms of loss of power on the left side, involving both fore and hind limbs,
but it could walk for a short distance without falling.
During the whole interval from the first inoculation to the date of death, covering a
period of 127 days, the hæmatozoon was never discovered in the blood, although it was
found on the 45th day in the fluid from the left tunica vaginalis testis.
It is a point of extreme interest that even in the absence of the hæmatozoon, such
grave cerebral symptoms presented themselves and were accounted for at the Autopsy by
the amount of fluid in the lateral ventricles, especially the right. On the eighteenth day
after re-inoculation as the hæmatozoon had not been discovered in the blood, it was de-
cided to inoculate two Guinea-pigs with blood from the animal, in order to prove whether
the organism existed in any form in the general circulation. This accordingly was done
and each animal received subcutaneously .7 c.c. of blood drawn from the ear of the sheep.
In the case of one Guinea-pig, the hæmatozoon appeared in the blood in ten, and in the
other after an interval of fourteen days. Eventually death took place in the former
after 58 days, and in the latter 139 days after inoculation.
It is, therefore, clinically a point of supreme importance to bear in mind, that the blood
of a sheep previously inoculated with the hæmatozoon of horse Surra, may at a much
later period contain, although probably impossible of demonstration, the particulate con¬
tagium which on being introduced into the circulation of another animal, has the power
of reproducing the disease.
No. 1.-GUINEA-PIG.
Month and
Date.
1891.
January.
24th...
25th...
26th...
27th...
28th...
29th...
30th...
31st...
February.
1st...
2nd. .
3rd...
4th...
5th...
6th...
7th...
8th...
9th...
10th...
11th...
12th...
13th...
14th...
15th...
16th...
17th...
18th...
19th...
20th...
21st..
22nd.
No. 1 Guinea-Pig.
Condition of blood.
Inoculated
.
... ...
......
......
......
......
......
......
......
......
Hæmatozoa absent
„
one
„
numerous
„
absent
„
numerous
„
absent
„ „
„ sparsely numerous .
„ very
„
„ swarming
„ very numerous
„ few
„ very numerous
„ „ „
„ „ „
„ „ „
„
absent...
„ „ „
„
numerous...
„
few
...
„
numerous...
Temperature.
°C.
A. M.
...
39.4
39.4
38.6
39.5
39.5
38.2
38.7
38.6
38.6
38.
38.8
39.6
39.
39.
39.1
37.8
38.8
38.7
38.7
38.5
39.2
38.6
38 .6
39.3
39.3
39.3
38.8
38.6
38.4
P. M.
39.2
39.8
39.8
39.6
39.8
38.1
38.9
37.9
39.
38.7
39.
39.8
39.5
39.2
39.2
39.3
37.9
38.9
38.9
38.8
38.8
39.5
38.8
38.8
39.5
39.4
39.5
38.9
38.7
Month and
Date.
February.
23 rd...
24th...
25th...
26th...
27th...
28th...
March.
1st...
2nd..
3rd...
4th...
5th...
6th...
7th...
8th...
9th...
10th...
11th...
12th...
13th...
14th...
15th...
16th...
17th...
18th...
19th...
20th..
21st..
22nd.
23rd..
38.6
Death at 2 P.M.
No. 1 Guinea-Pig.
Condition of blood.
Hæmatozoa numerous
„
„
...
„ „ ...
„ very
„ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„
numerous...
„ „ ...
„ „ ...
„ „ ...
„ ...
„ „ ...
„ swarming...
„ very numerous...
„ „ ...
„ „ ...
„ swarming...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
„ „ ...
Temperature.
°C.
A. M.
38.4
39.1
39.1
38.8
38.7
40.1
39.3
39.1
38.7
38.9
39.1
39.2
39.3
39.4
39.5
39.7
39.7
39.1
39.8
39.7
39.3
39.4
39.6
40.2
40.1
40.2
39.6
39:7
39.2
P. M.
38.7
39.4
39.4
38.9
40.5
40.2
39.5
39.3
39.9
39.3
39.4
39.5
39.6
39.7
39.8
39.8
39.8
39.4
39.8
39.8
39.5
39.7
39.8
40.2
40.3
40.3
39.8
39.8
39.7
Inoculated 24th January 1891, at 11-30 A.M.
Died 23rd March 1891, at 2-0 P.M.
58 days 2¼ hours after inoculation.
AUTOPSY.—The
animal is somewhat emaciated.
The pleural cavities are free from fluid, as also the peritoneal.
Lungs.—Pale in colour and large, filling up the whole cavity of the chest ; a few pete-
chiæ dotted over the surface of the organs.
Heart.—Is distended in all its cavities by coloured blood clots and presents numerous
ecchymoses on its anterior and posterior surfaces.
Liver.—Large, but healthy looking.
Kidneys.—Dotted over with small petechiæ, capsules strip easily.
Spleen.—Much enlarged, weighs 4 grammes (60 grs.)
Bladder.—Normal to naked eye.