71
The latent period of the disease was in no way altered by the administration of 150 grains of each
of the Iodides of Mercury and Arsenic, but the course of the paroxysms was undoubtedly modified to a
marked degree—only a few hæmatozoa being present at any one time in the blood examined—until a
few days before death ; and, although the disease ran on for over eight weeks, the animal still maintained
a fair condition. In this case the temperature assumed the typical relapsing type, which is rarely
observed in inoculated cases.
No. CIII.—Country-Bred, aged. This animal was subjected to a course of the Double Iodides of
Arsenic and Mercury, in gradually increasing doses, commencing with five cubic centimetres and ter-
minating with twenty-seven cubic centimetres, twice daily, with a view to determining whether its ad-
ministration would modify or destroy the Surra organism on subsequent inoculation. Between June
29th and July 28th, 1894, one thousand and seventy-four c.c. were administered. On 24th July this
animal's temperature, 36.7°C., commenced to rise, and at 5 P.M. on the 26th had attained 40°C., and for
the next two days remained high. On the morning of the 29th, the Surra hæmatozoon was found in
its blood, and remained present until death on the morning of the 1st August. It was the intention
to have continued the drugs for some time longer, previous to the subcutaneous injection of soiled
blood being made, but as accidental inoculation took place by a fly or flies, it is supposed from a Surra
horse standing some yards away, the experiment came to an end prematurely, showing that a mean of
35.8 c.c. of the Double Iodides, persisted in for thirty days, has no destructive effect upon the
Trypanosoma.
Owing to the reasons given below, the drugs administered in cases XCVIII and XCIX were
insufficient to withstand the unnatural test of subcutaneous inoculation.
It would appear that animals (horses) suffering from Surra have a greater tolerance of Arsenic
than healthy animals, when the drug is administered for a lengthened period, as in the above experi-
ments. Difficulty was experienced in getting the horses accustomed to be watered at a river or tank
to take the drug (in water), or even pure water from a bucket. No such difficulty occurred in treating
previously recorded Surra cases, received from the Tramway Company and Mounted Police, Bombay,
where the horses had always been used to the latter method. During an acute attack of disease only
lasting a few days it is easy to administer drugs by drenching ; but in the treatment of Surra, when it
is necessary to administer medicines to some twenty horses, two or three times daily, for a period of
some weeks, with no establishment but coolies, drenching is out of the question. Any unnecessary dis-
turbance of the animal and possible injury to the mouth is prejudicial, and would certainly retard
recovery.
TABLE OF TREATMENT No XXI.
Horse
Number.
CIV
CVII
CVIII
..
CIX
CX
CXI
CXII
..
CXIII .
CXIV .
Treatment.
Arsenic (Liquor Arse-
nicalis).
Do.
do. ..
Do.
do. ..
{
Do.
do.
Sulphate of Iron
Arsenic Liquor Arse-
nicalis.
Do.
do.
..
Do.
do.
.
Do.
do. .
Do.
do.
How
adminis-
tered.
Gastric in-
gestion.
Do. ..
Do. ..
Do. ..
Do. ..
Do. ..
Do. ..
Do. ..
Do. ..
Do. ..
Minimum
dose.
Grs.
2.0
4.0
2.5
2.0
1 drachm)
1.0
2.0
4.0
2.5
1.5
Maximum
dose.
Grs.
6.0
6.0
7.0
7.0
drachm
1.0
grains.
7.0
7.0
7.0
6.0
6.0
Total quantity of
each drug
administered in.
Grs.
236.0
52.0
378.0
561.0
47 drachms.
321.0
408.0
539.5
135.5
92.5
Date from—to
under each
form of
treatment.
{14th
August
1894.
17th Septem-
ber 1894.
{25th Septem-
ber 1894.
4th
October
1894.
27th Septem-
{ ber 1894.
20th Novem-
ber 1894.
{5th
Novem-
ber 1894.
15th
January
1895.
{ 3rd Decem-
ber 1894.
26th
Decem-
ber 1894.
{ 5th Novem-
1894.
21st
Decem-
ber 1894.
5th Novem-
1894.
26th
Decem-
ber 1894.
{ 9th Novem-
ber 1894.
23rd January
1895.
{29th
Novem-
ber 1894.
13th Decem-
ber 1894.
{29th Novem-
ber 1894.
12th Decem-
ber 1894.
No. of
days
under
form
of
treat-
ment.
} 35
}10
} 55
} 68
} 24
} 50
}52
}76
}15
}14
Date of
disappearance
of hæmato-
zoon from
the blood.
18th August
1894.
29th Septem-
ber 1894.
29th Septem-
ber 1894.
10th Novem-
ber 1894.
Do.
9th
Novem-
ber 1894.
10th Novem-
ber 1894.
12th Novem-
ber 1894.
3rd Decem-
ber 1894.
2nd Decem
ber 1894.
Date of
re-appearance
of hæmatozoon
in the blood.
}
8th December
1894.
....
....
....
No. of
days
hæma-
tozoa
absent
31
6
53
66
43
18
73
11
11
Result
of treat-
ment.
Death .
Do.
Do.
Do.
Do.
Do.
Do.
Do.
Do.
No. of
days
which
elapsed
between
first
appear-
ance of
disease
and
death.
42
12
59
97
63
69
79
35
21
No. of
days
under
treat-
ment
for
Surra.
35
10
55
68
50
52
76
15
14