66
It has previously been noted that the most common periods during treatment by Arsenic, in which
the hæmatozoon re-appears in the circulation of equines, whose systems are under the influence of the
drug, is somewhere about the 25th, 50th or 75th day of an intermission, i.e., subsequent to the dis-
appearance of the organism from the circulation of the animal. This gives one an idea of the deterrent
effect produced on the immature form of the Surra hæmatozoon, and its great tenacity of life, for in or
dinary cases of Surra the intermissions between the paroxysms, rarely if ever, exceed a maximum
duration of seven days.
No. CXV, a Persian Gulf entire horse, aged 4 years, belonging to the Bombay Mounted Police
It was seized with fever (temperature 105°F.) in the middle of October 1894. This animal was pur-
chased on the 16th July 1894, and Surra was diagnosed on the 23rd November 1894; there is, there-
fore, no doubt that the disease was contracted in Bombay. The horse was sent to the Poona Labora.
tory on November 29th, and the same evening the Arsenical Treatment was commenced, i.e., the 2lst
day of the disease, just at the termination of an intermission, probably the second. The hæmatozoon
was present in the blood whilst under observation from the 22nd to the 25th day of the disease, but
after the latter day did not recur; but two days later an urticarial eruption, involving the under-
surface of the abdomen and thighs, appeared and persisted for 24 hours. In all 455 grains of Arsenic
were administered in sixty-three days, after which Sodium Iodide in two-drachm doses was continued
twice daily for seventy-two hours. The animal made an uninterrupted recovery, and was returned
from Poona to the Mounted Police, Bombay, on 9th March 1895, cured. Two days later a Board
there examined and reported 'that the animal was sound and healthy, and certified it fit for duty'
A letter received from the Commissioner of Police, Bombay, 3rd January 1898, states ' that the horse i s
still alive, and in good health and condition,' three years and two months after the attack of Surra.
TABLE No. XIX.
Horse CXV.— Entire, Persian, aged 4 years, Cured.
Day of Month.
1894.
December 4th.
12th
...
21st
...
30th
...
1895.
January
9th
19th
...
28th
February
5th
14th . ..
22nd
...
March
3rd
9th
..
Day
of
Disease.
26th
34th
43rd
52nd
62nd
72nd
81st
89th
98th
106th
115th
121st
Day of
Treat-
ment.
6
14
23
32
42
52
61
69
78
86
95
101
Total
amount of
Arsenic
up to
date.
Grs.
38
127
217
277
357
427
465
473
...
...
...
Amount to date
of Sodium
Iodide and
Potass-Nit.
...
...
...
...
...
xvi.
KNO 3 iv.
xiv.
...
Red blood
Corpuscles.
8,440,000
8,280,000
8,100,000
7,640,000
8,720,000
7,130,000
9,480,000
9,300,000
8,750,000
8,250,000
8,160,000
7,990,000
White
blood
Corpuscles.
17,800
9,600
5,600
9,400
9,400
8,800
10,000
9,200
9,800
8,200
6,400
7400
Coarsely
granular
Cells.
800
1,000
400
600
800
800
600
600
400
80
200
340
Remarks
40th day Temp. 103.3°F,
39.6 ° C.
5th crystals of hæmoglobin in
the blood.
Cured.
The second case under this heading, Horse No. CXIX., lived for 209 days after the hæmatozoon
appeared in the blood. The animal was under treatment for the same period, during which time it
lost flesh, but later regained it, and weighed 11 maunds or 904 lbs. Hopes were entertained of bei ng
able to save this animal, but on the 16th May, the establishment of the Laboratory were removed t o
Muktesar, North-Western Provinces, 1,120 miles distant from Bombay. So this animal was left at the San¬
gam Veterinary Hospital under the charge of the Veterinary Graduate in charge. Unfortunately the
telegraph was not at that time connected with Muktesar, and telegrams were frequently not delivered
at their destination for 4 or 5 days after being despatched, consequently instructions wired as to the
treatment of the animal were useless. Arsenic to the amount of 2,239 grains was administered to
the animal during 209 days, equal to a daily dose of 10.71 grains ; death resulted from Chronic Arse-
nical poisoning.