56
again the Surra organism made its appearance in the blood, and remained with one exception, 9th, from
the 5th to the 10th of April. At this period of the case (April 8th) the animal assumed the recumbent
position, and when placed in slings fell forward, so after several unsuccessful attempts to get it to stand,
further trials were abandoned. It was recognised that if the animal was left in this condition, death
would ensue after 24 or 36 hours of severe struggling, consequently a novel treatment was resorted to,
viz., the subcutaneous injection of glycerine extracts of the spleen and testicles of the sheep, 2. c.c. of
each. On the morning of 9th, the animal assumed the erect position without assistance. Further
injections were made of spleen 2.5 c.c. alone on the 10th, spleen and testicle combined, 2.5 c.c. of each on
the 12th and 14th April. Death took place on the 24th April, the 148th day of the disease, but during
the interval of 16 days until the evening of the 23rd April the animal was able to lie down and get up,
without any assistance. In all 814 grains of Arsenic were administered during the 136 days the animal
was under treatment. The temperature varied between a maximum of 40.2°C. (104.3 °F.) and a
minimum of 37.1°C. (98.8°F.).
Autopsy.-Body somewhat emaciated, slight swelling and œdema of the fetlocks. Thorax, no
fluid, no adhesions of the pleuræ. Lungs—anterior lobes seat of emphysema. On section œdema of
lungs. Pericardium sac contains one ounce of amber-coloured fluid. Heart weighs 4 lbs. 5½ ozs.,
base of organ petechiated. On section healthy. Abdominal Cavity contains few ounces of a clear amber
fluid. Liver 9 lbs. 6 ozs., old perihepatitis. On section tissues pale, spleen 2 lbs. 11 ozs. On
section tissues firm. Kidneys.—Right 1 lb., 3 ozs., Left 1 lb. 5½ ozs. The capsules strip easily; on
section tissues dark in colour. Stomach.—On section half full semi-digested food, villous portion,
mucous membrane presents a pale rose colour, tenacious mucus covering the surface of the organ.
Small spiroptera tumour midway between openings. Small Intestines-mucous membranes congested
patches present. Large Intestines healthy. Bladder ditto.
CXXIII.--Persian-Gulf Entire horse, aged 6 years, belonging to the Bombay Mounted Police, was
purchased on the 13th December 1891. From the above date until December 14th, 1894, when the animal
was observed to be ailing, it was stationed in and around Bombay. From the 1st to 21st October 1894,
thirty-five pounds of green grass was given daily as fodder, but previous to and since the above period,
grain or some kind of corn and dry grass constituted the daily ration. From 14th to 22nd December
under treatment at the Veterinary College Hospital, Parel. The horse was received at the Laboratory
stables at 7-30 A.M., 23rd December. State on admission.—Animal in poor condition, presents a dull
appearance. Visible mucous membranes injected and conjunctivæ tinged an orange colour and pete-
chiated. Skin hot, ordinary symptoms of fever present. Temperature 40.8°C, Pulse rapid, full and
bounding, 72. Respirations frequent and shallow, 32. Swelling and œdema of the sheath, scrotum
and extremity. Off feed. Dung glairy and offensive. Hæmatozoa very numerous in the blood. On
the evening of its arrival the animal was subjected to Arsenic (grs. v) in the form of Liquor Arseni-
calis, the dose to be gradually increased. The hæmatozoon disappeared from the circulation after 15
grains had been administered and continued absent until the 13th February, an intermission of 50 days'
duration. During this period the drug was stopped on two occasions for 7½ and 3 days respectively, on
account of slight gastric symptoms appearing. Up to this date 335 grains had been readily taken in
the fluid imbibed. On this occasion only one hæmatozoon was observed in two cover-glass specimens of
blood. The Arsenical treatment was continued until March 3rd, when the animal refused fluid in any
form if the drug was mixed with it, and a few days later the temperature began to rise and death took
place at 2 A.M. on the 16th March 1895. During the 81 days the case lasted 580 grains of Arsenic
were administered, the temperature varied between a maximum of 40.8°C. and a minimum of 36°C.
Autopsy.—Body fairly nourished. No œdema present. Thorax.—No fluid or adhesions. Lungs
anterior lobes seat of emphysema, on section tissues present healthy appearance. Pericardial sac
contains a few drachms of a clear fluid. Heart 5 lbs. 4 ozs. On section right side of heart, membranes
blood-stained, Left membranes present mottled appearance, probably fatty change. Abdominal cavity
free from fluid. Liver 10 lbs. 5 ozs., old perihepatitis, on section tissues dark and somewhat friable,
Spleen 2 lbs. 12 ozs., somewhat enlarged, on section tissues firm. Kidneys.—Right 1 lb. 7 ozs., Left
1 lb. 6 ozs., capsules strip easily, on section organs pale. Stomach distended with food, on section
mucous membrane of villous portion presents a rose colour, more particularly bordering on the line of
demarcation. Small Intestines present a healthy appearance; Large ditto. Bladder vessels highly
injected, and mucous membranes varying in colour from yellowish red to a deep red.
CXXIV.—Persian Gulf Entire horse, aged 7 years, belonging to the Bombay Mounted Police, was
purchased 16th July 1894. During the time which elapsed between the above date and recognition of
the disease the animal was located in and around the City of Bombay. It was taken for treatment to
the Veterinary College Hospital, Parel, on 6th December, and later on the 23rd of the same month was
received at the Laboratory stables. State on admission.—Animal in poor condition, presents a dull
appearance, symptoms of fever are present. The visible mucous membranes are injected ; the conjunctivæ
are petechiated, lachrymation excessive. Skin hot, temperature 40.3°C., Pulse frequent, 68 ; Respirations
rapid and shallow, 56 ; some swelling and œdema of the extremities. Appetite poor. Dung natural in
character. Hæmatozoa few in the blood.
The animal was placed on a treatment of Arsenic in form of Liquor Arsenicalis, in increasing doses
commencing with grs. v twice daily. The hæmatozoon disappeared from the circulation after 26 grains had
been given, and up to the time of death on February 8th, a period of 45 days, had not re-appeared. In all
389.5 grains of Arsenic were administered. A marked feature in this case was that from the first dose
of Arsenic on the evening of the 23rd December until the 10th January 1895 the temperature gradually