57
declined from 40.5°C. to 37.4°C., the evening reading then gradually rose until 38.9°C. was registered on
the 19th January, again the temperature gradually rose from 37.8°C. on the evening of 2nd February to
39.2°C. on the day previous to death.
Autopsy.—Body
somewhat emaciated, absence of swelling and œdema. Thorax nil. Lungs
present a healthy appearance. Pericardium contains about a drachm of clear fluid. Heart 5 lbs. 12¼
ozs. On section present healthy appearance. Abdominal cavity free from fluid. Liver 10 lbs. 10½ ozs.
Old perihepatitis, on section tissues healthy. Spleen 2 lbs. 1½ ozs., on section tissues appear healthy.
Kidneys.—Right 1 lb. 3 ozs., Left 1 lb. 1½ ozs. Capsules strip easily. On section tissues appear healthy.
Stomach, villous portion, mucous membrane seat of catarrhal inflammation. Intestines healthy. Bladder
ditto.
CXXV.—Persian-Gulf gelding, aged 11 years, belonging to the Bombay Tramway Company, was
noticed to be ailing with fever on the 27th January and was removed to the Infirmary. On the following
day the hæmatozoon was discovered on microscopical examination of the blood. The animal was received
at the Laboratory stables on 30th January.
State on admission.—Animal in fair condition, fetlocks overshot. Fever present, visible mucous
membranes are injected and orange in colour. Conjunctivæ petechiated, excessive lachrymation. Skin
hot. Temperature 40.2°C. Pulse full, somewhat hard, 60. Respiration 16. Extremities seat of some
swelling and œdema, but not tender on manipulation. Appetite good. Dung healthy in appearance.
Hæmatozoa numerous in the blood. Red blood corpuscles form rouleaux and the white corpuscles are
not increased in number. The animal was placed on Arsenic, grs. v twice daily. Dose to be increased
later. The hæmatozoon disappeared from the blood after one dose had been administered, and remained
absent up to time of death which occurred on the night of February 4th. Forty-four grains of Arsenic
were.given during the five and half days the animal was under treatment. The temperature varied
between a maximum of 40.5°C. and a minimum of 37.2°C.
Autopsy.—Body well nourished, thick layer of adipose tissue beneath abdominal walls. All the
tissues of body stained yellow in colour. Thorax contains no fluid, no adhesions. Lungs present a
healthy appearance. Pericardium contains about a drachm of orange-coloured fluid. Heart 6 lbs.
7¼ ozs. Organ enlarged. Dilatation of right side of heart. Hypertrophy of walls of left ventricle. No
sub-endocardial petechiæ. Abdominal Cavity free from fluid. Liver 13 lbs. 10 ozs. Old perihepatitis.
Lymphatic vessels on both anterior and posterior surfaces stand out, injected with a clear, colourless
fluid. On section tissues pale and friable. Spleen 2 lbs. 1 oz. On section tissues normal in appearance.
Kidneys.—Right 1 lb. 5¼ ozs. Left 1 lb. 4¾ ozs. Capsules strip easily. On section tissues very pale.
Stomach presents a healthy appearance. Intestines ditto. Bladder ditto.
(ii).—INOCULATED CASES BY GASTRIC INGESTION OF BLOOD.
No. XCVI.—Country-Bred Entire, aged, purchased for experimental purposes on 17th October 1893.
On admission.—The animal is in fair condition, but apparently free from disease. The visible mucous
membranes are clear, with the exception of the conjunctivæ which are injected. Temperature 38°C.
Pulse 36. Respiration 12. The appetite is good and the dung healthy in appearance. On the 18th
October the animal was inoculated by the gastric ingestion of four ounces of Surra blood taken from
the jugular vein of horse No. XCV immediately after death. Ante-mortem the blood contained very
numerous hæmatozoa. The latent period occupied between 7 and 8 days. On the evening of the day the
hæmatozoon was discovered in the blood the animal was submitted to a treatment with Arsenic (grs. iv)
in the form of Liquor Arsenicalis, one grain being added each day to the original quantity (grs. viii)
until 12 grains were reached. The only paroxysm lasted for five days and the hæmatozoon disappeared
from the circulation after 46 grains of Arsenic had been administered. The intermission which followed
extended over a period of eleven days, and early on the morning of the 12th day the animal succumbed.
The temperature varied between a maximum of 40.6°C. during the paroxysm, and a minimum of 35.2°C.
during the intermission. In all 178 grains of Arsenic were given during the 15½ days the animal was
under treatment, or daily mean of 11.6 grains.
Autopsy.—Body emaciated, no œdema of the extremities. Thoracic cavity free from fluid and
adhesions. Lungs emphysematous throughout. Sub-pleural extravasations on both organs.
Pericar-
dium.—The sac contains 6 ounces of a blood-stained fluid. Heart 5 lbs. 7 ozs., presents a healthy
appearance. Abdominal cavity free from fluid. Liver 6 lbs. 15 ozs., old perihepatitis, small yellowish
white calcareous nodules scattered over the surfaces of the organ. On section tissues dark in colour,
nodules scattered through the structures of the organ. Spleen 1 lb. 1 oz., both surfaces dotted over with
bright red coloured petechiæ. On section tissues dark and flabby. Kidneys.—Right 13½ ozs., Left
16½ ozs., organs healthy.
Stomach contracted.
On section, walls thickened.
Cuticular portion
presents several tumours, one large and several small. On section, the large tumour contains a yellow
gelatinoid material.
Villous portion.—The mucous membrane presents one large extravasation of
blood lying beneath the mucosa, and a Spiroptera tumour from which a small quantity of a saneous
fluid exudes. Duodenum mucous membranes injected. Small Intestines contain a yellow coloured fluid,
the mucous membrane is covered with a yellow gelatinous material which is also present on the mucous
membrane of the rectum. Bladder contains 740 c.c. of turbid, viscid greenish yellow coloured fluid.
Specific Gravity 1040, containing 5 grammes of urea per 100 c.c.
Two Guinea Pigs were inoculated on the 3rd November 1893, with 0.3 c.c. of blood each (from which
the organisms appeared to be absent on microscopical examination) taken from the jugular vein of
Horse No. XCVI, on the 9th day of the disease after 88 grains of Arsenic had been administered.
B 2204—15