55
sent to the Veterinary College Hospital, Parel, on 4th December, when the hæmatozoon was discovered
in the blood. The animal was received at the Laboratory stables on 10th December. State on admis-
sion.—Animal presents a very dull appearance, and is in poor condition, ribs showing. Visible mucous
memberanes pale, right conjunctival membrane petechiated, left free. No œdema or swelling visible.
Skin hot. Temperature 40.5°C., Pulse 60, Respiration 20. Complete loss of appetite. Sphincter ani
relaxed and slight prolapse of rectum. Hæmatozoa are present in small numbers in the blood. On the
evening of the 10th the animal was subjected to a treatment consisting of Liquor Arsenicalis (grs. v) in
gradually increasing doses, later to be altered according to the condition of the patient. After 15
grains had been taken the hæmatozoon disappeared from the blood, and continued free until the end of
the case, on January 15th, 1895, when death took place, a period of 34 days. In all 198 grains of
Arsenic were administered. The temperature varied during the period the animal was under observation
between a maximum of 40.3°C. and a minimum of 35.7°C. but rose again slightly just before death.
Autopsy.—Body fairly nourished, no swelling or œdema of limbs.
Thorax.—No fluid or adhesions. Lungs large and occupy the whole cavity of the chest. On
section organs œdematous. Pericardium contains few drachms of fluid. Heart 4 lbs. 11 ozs., healthy.
Abdominal Cavity free from fluid. Liver 1 lb. 1 oz., old perihepatitis. On section tissues dark-
red in colour, but healthy in appearance.
Spleen 1 lb. 3½ ozs., somewhat small. On section tissues firm, &c.
Kidneys.—Right 1lb. 14½ ozs., left 1 lb. 13½ ozs. On section tissues healthy. Stomach.—Cuticular
portion stained yellow, villous healthy appearance.
Large and Small Intestines, ditto. Bladder ditto.
CXXI.—Persian-Gulf Entire Horse, aged 5 years, belonging to the Bombay Mounted Police,
(No. 96), purchased during July 1894, was observed to be ailing on November 20th. A few days later
it was admitted to the Veterinary College Hospital, Parel, where the hæmatozoon was discovered on 3rd
December. The animal was received into the Laboratory stables on 10th December. On admission.—
The horse is in fair condition, the visible mucous membranes are of an exceeding pale yellow colour,
but there are no petechiæ present. Skin is hot. Temperature 40.5°C. Pulse accelerated, 90 per
minute, bounding in character. Respirations quick and shallow, 41. No œdema or swelling of the
extremities, &c. Appetite fair. Dung normal in character. The hæmatozoa are swarming in the blood.
Ratio of white to red corpuscles 1 : 179. On the evening of its arrival the animal was submitted to a
treatment of Arsenic (grs. v) in gradually increasing doses. After the first dose of the chemical the
hæmatozoon disappeared from the blood and did not re-appear. The temperature oscillated between a
maximum of 41.6°C. (106.9 °F.) and a minimum of 36.7°C. (98.06.°F). Death occurred on the 24th
December. In all the animal received 118 grains of Arsenic.
Autopsy.—Body somewhat emaciated, no swelling or œdema of the extremities. Thorax.—No
fluid or pleural adhesions. Lungs, healthy appearance. Pericardium sac contains about two-thirds of
an ounce of clear fluid. Heart 5 lbs., healthy. Abdominal cavity free from fluid. Liver weighs 13
lbs. 4½ ozs., old perihepatitis, few calcareous nodules. On section tissues dark, somewhat friable.
Spleen 1 lb. 9½ ozs., healthy. Kidneys.—Right 1 lb. 15 ozs., Left 1 lb. 12 ozs. Stellate veins injected.
On section tissues dark but appear healthy. Stomach, healthy. Large and Small Intestines ditto.
Bladder ditto.
CXXII.—Persian-Gulf Entire Horse, aged 6 years, belonging to the Bombay Mounted Police,
(No. 96), was purchased during the rains of 1894. The animal was first observed to be ailing on
November 20th, and was sent to the Veterinary College Hospital at Parel, where the Surra hæmatozoon
was discovered on November 28th, 1894. The horse arrived at the Laboratory stable at 7-30 A.M.,
on December 10th. State on admission. The animal is in fair condition. The visible mucous
membranes are very pale, conjunctival membranes clear and not petechiated. The skin is hot. Tem-
perature 39.3°C., pulse 48, respiration 16. There is no swelling or œdema of the extremities or under-
surface of the abdomen. Appetite good, excreta normal in appearance. Hæmatozoa few in the blood.
On the evening of its arrival the animal was subjected to a treatment consisting of Arsenic (grs. v) in
the form of Liquor Arsenicalis, the dose to be gradually increased. The hæmatozoon disappeared from the
blood after 38 grains had been administered. From the 10th to the morning of the 21st December, 130
grains were given, but on account of gastric symptoms intervening, the medicine was discontinued from
the evening of the 21st to that of 27th December. From this time the dose of Arsenic was lowered to grs.
iii, twice daily, but later was increased by one grain at a time, and continued until January 18th, 1895.
Amount given during second period was 208 grains, making a total of 338 grains. From the evening of
the 19th to the 25th January the animal was again allowed a respite from the drug, but it was recommenced
on the evening of the latter date, and continued in small doses until the 31st January, when gastric
symptoms again supervened. Sodium Iodide was substituted, and continued in two-drachm doses until
twelve drachms had been given. Unfortunately on the 53rd day of the intermission owing to the break in
the Arsenical treatment for the reasons above given the hæmatozoon re-appeared in small numbers for one
day only (February 4th). Again the Arsenical treatment was pushed from this latter date to March
26th, with two periods of rest, 7½ and 7 days, during which 226 and 162 grains were respectively administered.
But after this second intermission lasting 49 days one hæmatozoon was found in two large cover-glass
specimens of blood. The further ingestion of Arsenic was abandoned during the next 9 days, and
intravenous injections of two grains on the 26th and 4 grs. on the 29th December were substituted; but