59
Intestines healthy. Bladder ditto.
In this case the latent period of the disease was not lengthened, but the organisms only attained
to very numerous between 20 and 50 in a field of the microscope on four occasions during a period of
51 days the case lasted. Great difficulty was experienced in getting the animal to take the drug,
so that although gastric symptoms appeared, the full physiological effect of the Arsenic was never
produced.
Preliminary Treatment by Arsenic.
CII.—Country-Bred gelding, aged.
Arsenic administered from 27th June 1894.
In all 430 grains were given.
Death 9 P.M. 29th July 1894.
The animal received an average of 13 grains for 33 days.
Death took place from Arsenical poisoning somewhat suddenly just before the date for the inocu-
lation test.
Iodide of Arsenic and Mercury.
No. XCIX.—Australian Gelding, aged. After a period of observation lasting eight days, during
which daily observations were recorded of the water drunk, urine passed, and total urea excreted.
The animal was submitted to a course of medicine consisting of the Double Iodides of Arsenic and Mer-
cury, with the same object in view as in the case of No. XCVIII animal. The first dose of v. c.c. was
administered on the evening of the 5th April 1894, and continued in increasing quantities until the
morning of May 21st, a period of 46 days. In all 158 grains of each salt, Iodide of Arsenic and Iodide
of Mercury were given. At 5 P.M. on 21st May the animal was subcutaneously inoculated with
0.8 c.c. of blood containing swarms of hæmatozoa taken from the heart of a Guinea Pig immediately
after death. The period of incubation lasted five days, and the case lasted 59 days from the first ap-
pearance of the organism in the blood. There were 7 paroxysms lasting 24 days, and 7 intermissions
lasting 35 days. As no protection against the Surra hæmatozoon had been conferred by the prelimi-
nary treatment of the Double Iodides, the animal was again submitted to the same salts, but in addition
a small dose of Arsenic as Liquor Arsenicalis was administered at intervals. During the first five
paroxysms the fever assumed the typical relapsing form, for within a few hours the temperature
fell from over 41°C. to 37.4°C. equal to 7°F. and on a second occasion from 41.8ºC. to 36.8ºC. equal to
9.2°F., but during the latter part of the case the temperature oscillated in the most irregular manner.
Until six days before death the organism never exceeded few (5 in a field), but frequently there was
only one in a cover glass specimen of blood.
Autopsy.—Body fairly nourished, no œdema of extremities.
Thorax free from fluid and pleural adhesions. Lungs healthy. Pericardium, few drachms of fluid
in the sac. Heart 6 lbs. 12¼ ozs. Right ventricle two small sub-endocardial extravasations. Left
ventricle several ditto. Abdominal cavity free from fluid. Liver 17 lbs. 1 oz.; much enlarged.
Spleen 5 lbs. 12¼ ozs., three times normal size. Numerous sub-capsular petechiæ.
Kidneys.—Right 1 lb. 13½ ozs., Left 2 lbs. 1½ ozs., double healthy weight. Capsules strip easily.
Surfaces of both organs petechiated, &c.
Stomach.—Mucous membrane of villous portion presents rose-coloured patches, no ulceration or
erosion.
Intestines healthy. Bladder ditto.
The latent period of the disease was in no way altered by the administration of 150 grains of each
of the Iodides of Mercury and Arsenic, but the course of the paroxysms was undoubtedly modified to a
marked degree, only a few hæmatozoa being present at any one time in the blood examined, until a few
days before death, and although the disease ran on for over eight weeks, the animal still maintained a
fair condition. In this case the temperature assumed the typical relapsing type which is rarely observ-
ed in inoculated cases.
Guinea Pig inoculated with 0.4 c.c. of blood from which the organisms were absent, taken from
the heart of Horse No. XCIX, 7 hours after death. The latent period occupied 16 days, from the first
appearance of the organism on the 9th August, to death on 15th September, 38 days elapsed, made up
of 3 paroxysms lasting 29 days and 2 intermissions lasting 8 days.
Preliminary treatment. Iodides of Arsenic and Mercury. Subsequent inoculation.
No. CIII.—Country-Bred, aged. This animal was subjected to a course of the Double Iodides of
Arsenic and Mercury in gradually increasing doses, commencing with five cubic centimetres, and ter-
minating with twenty-seven cubic centimetres twice daily with a view to determining whether its admi-
nistration would modify or destroy the Surra organism on subsequent inoculation. Between June 29th
and July 28th, 1894, one thousand and seventy-four c.c. were administered. On 24th July, this
animal's temperature, 36.7°C., commenced to rise and at 5 P.M. on the 26th had attained 40°C., and for
the next two days remained high. On the morning of the 29th, the Surra hæmatozoon was found in