Advances on Modeling in Tissue Engineering [electronic resource] /
Fernandes, Paulo R.editor.
Bártolo, Paulo Jorge.editor.
This book presents a collection of chapters describing the state of the art on computational modelling and fabrication in tissue engineering. Tissue Engineering is a multidisciplinary field involving scientists from different fields. The development of mathematical methods is quite relevant to understand cell biology and human tissues as well to model, design and fabricate optimized and smart scaffolds. The chapter authors are the distinguished keynote speakers at the first Eccomas thematic conference on Tissue Engineering where the emphasis was on mathematical and computational modeling for scaffold design and fabrication. This particular area of tissue engineering, whose goal is to obtain substitutes for hard tissues such as bone and cartilage, is growing in importance.
Description based upon print version of record.
Advances on Modeling in Tissue Engineering; Contents; Preface; Cell mechanics: The role of simulation; 1 Introduction; 2 What is the Role of Mechanical Simulation in cell Biology?; 2.1 Verification, Validation, and Sensitivity; 2.2 The Paradox of Validation; 3 State-of-the-art in Computational Cell Mechanics; 3.1 Homogenization; 3.2 The Cytoskeleton; 3.3 The Cell Membrane; 3.4 Whole Cell Models and Multiscale Approaches; 4 Future Directions; 5 Conclusions; References; Multiscale Modelling of Bone Tissue - Remodelling and Application to Scaffold Design; 1 Introduction
2 Bone remodelling multiscale Problem3 Computational Model; 4 Multiscale modelling of the femur bone; 5 Scaffolds design; 6 Microstructures Fabrication; 7 Concluding Remarks; Acknowledgements; Nonlinear Elastic Scaffold Design, Modeling and Fabrication for Soft Tissue Engineering; 1 Introduction; 2 Standardized Nonlinear Elastic Models for Scaffold Design Targets; 2.1 Fung 1D Exponential Strain Energy Function; 2.2 Ogden Strain Energy Function; 2.3 Anisotropic Extension of the Ogden Strain Energy Function for Fiber Reinforced Tissues
3 Porosity Effects on Nonlinear Elasticity: Experimental and Computational Studies on Elastomeric Scaffolds4 Summary; Acknowledgments; References; Computational techniques for selection of biomaterial scaffolds for tissue engineering; 1 Introduction; 2 Micro-Finite Element models for the determination of mechanical stimuli within tissue engineering constructs; 2.1 Overview; 2.2 Micro-Computed tomography based models.; 2.3 Benefits of micro-Finite Element models; 3 Continuum modelling of cellular processes; 3.1 Overview; 3.2 Application to tissue engineering
4 Lattice-based models to simulate cellular activity4.1 Overview of lattice-based modelling; 4.2 Application to tissue engineering; 4.3 Benefits of lattice approach; 5 Discussion and conclusions; Acknowledgments; REFERENCES; Modelling bone tissue engineering. Towards an understanding of the role of scaffold design parameters; 1 Motivation of numerical simulation on tissue engineering; 2 A multiscale strategy in bone tissue engineering; 2.1 Numerical analysis of the macroscopic scale; 2.2 Microscopic model of bone ingrowth
2.3 Microscopic model of the biodegradation kinetics in polymeric scaffolds2.4 Variational formulation; 3 Results: analysis of scaffold microstructural anisotropy; 4 Conclusions; References; Geometric modeling and analysis of bone micro-structures as a base for scaffold design; 1 Overview; 2 Bone micro-imaging technologies; 3 Extracting 3D bone structural parameters; 4 Reconstruction of bone micro-structures; 5 Scaffold design using texture synthesis techniques; 6 The approach; 7 The texture synthesis algorithms; 7.1 The voxel-by-voxel algorithm
7.2 The extended voxel-by-voxel (EVolV) algorithm
Includes bibliographical references.
This book presents a collection of chapters describing the state of the art on computational modelling and fabrication in tissue engineering. Tissue Engineering is a multidisciplinary field involving scientists from different fields. The development of mathematical methods is quite relevant to understand cell biology and human tissues as well to model, design and fabricate optimized and smart scaffolds. The chapter authors are the distinguished keynote speakers at the first Eccomas thematic conference on Tissue Engineering where the emphasis was on mathematical and computational modeling for scaffold design and fabrication. This particular area of tissue engineering, whose goal is to obtain substitutes for hard tissues such as bone and cartilage, is growing in importance.
Computer-aided engineering.
Biomedical engineering.
Biomaterials.
Computational intelligence.
Cell biology.
Computer-Aided Engineering (CAD, CAE) and Design.
Biomedical Engineering and Bioengineering.
Biomaterials.
Computational Intelligence.
Cell Biology.
Computational methods in applied sciences