Midkine: From Embryogenesis to Pathogenesis and Therapy [electronic resource] /
Ergüven, Mine.editor.
Muramatsu, Takashi.editor.
Bilir, Ayhan.editor.
Carl Edward Sagan’s (1934-1996) one of the famous quotation was “Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.“ From past to date, well-known molecules, enzymes, proteins, lipids and carbohydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgotten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named “Midkine” This book summarizes the extensive up-to-date literature overview with the latest work of experts about midkine in a detailed format that conveys its role as both a pathologic factor and therapeutic agent.
Description based upon print version of record.
Midkine: From Embryogenesis to Pathogenesis and Therapy; Preface; Contents; Part I: General Aspects of Midkine; Chapter 1: General Information on Midkine; Introduction; Protein and Gene; MK Signaling; Development and Reproduction; Repair and Inflammation; Cancer; MK and MK Inhibitors as Therapeutics; References; Chapter 2: The Role of Midkine in Neural Development and Patterning; Midkine-Related Growth Factors and Their Function in the Nervous System; The Role of Midkine in Neurogenesis of Vertebrates
Functional Divergence of Two Duplicated Midkine Genes in Zebra fish Reveals Distinct Roles During Neural Development Midkine-A Controls Floor Plate Formation in the Developing Spinal Cord of Zebra fish; The Role of Midkine-B in Cell Fate Specification at the Neural Plate Border; Downstream of Midkine: Anaplastic Lymphoma Kinase (ALK), A Putative Midkine Receptor Mutated in Neuroblastoma; Other Midkine Receptor Candidates in the Nervous System; References; Chapter 3: Midkine: A Player in Innate Immunity; Innate and Adaptive Immunity; AMPs: Effector Molecules of Innate Immunity
Characteristics of AMPs Mechanism of AMPs; Bacterial Resistance to AMPs; MK: A Host Defense Protein?; Influence from Salt; Evolutionary Aspects on the Antibacterial Activity; Interaction with Phagocytes; Roles in Health and Disease?; Conclusions and Perspectives; References; Chapter 4: Midkine/P63 Axis in Regulation of Epithelial-Mesenchymal Transition; Epithelial-Mesenchymal Transition and Cancer; Epithelial-Mesenchymal Transition and Growth Factors; Transcriptional Regulation of Epithelial-Mesenchymal Transition; Midkine/P63 Axis in Epithelial-Mesenchymal Transition; References
Chapter 5: Immunochemical Methods for the Detection of Midkine in Samples of Human Origin Introduction; MK-Specific Antibodies; Overview; Polyclonal MK-Specific Antibodies; Monoclonal MK-Specific Antibodies; Immunochemical Applications of MK-Specific Antibodies; Immunohistochemistry and Its Applications; Western Blot Analytics and Its Applications; ELISA and Its Applications; Overview on ELISA Method; Details and Applications of Non-commercial ELISAs; Details and Applications of Commercial ELISAs; Comparative Study for Midkine ELISA Determination; References
Chapter 6: Circulating Midkine in Malignant, Inflammatory, and Infectious Diseases: A Systematic Review Introduction; Materials and Methods; Literature Search and Selection of Publications; Evaluation of the Quality of the Research; Data Analysis; Results; Interpretative Synthesis of Data; Circulating Midkine in Cancer; Midkine as a Tumor Marker; Midkine in the Blood; Midkine in Inflammatory and Infectious Diseases; Conclusions; References; Part II: Midkine and Inflammation; Chapter 7: Midkine in Inflammation and Inflammatory Diseases; Midkine and Inflammation
Midkine in Inflammatory and Infectious Diseases
Includes bibliographical references and index.
Carl Edward Sagan’s (1934-1996) one of the famous quotation was “Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.“ From past to date, well-known molecules, enzymes, proteins, lipids and carbohydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgotten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named “Midkine” This book summarizes the extensive up-to-date literature overview with the latest work of experts about midkine in a detailed format that conveys its role as both a pathologic factor and therapeutic agent.
Medicine.
Life sciences.
Pharmacy.
Biomedicine, general.
Medicine/Public Health, general.
Life Sciences, general.
Pharmacy.