Optimal high-throughput screening : practical experimental design and data analysis for genome-scale RNAi research /
Zhang, Xiaohua Douglas,1966-author.
Cambridge : Cambridge University Press,
2011.
"This book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening experiments from a statistically sound basis"--Provided by publisher.
Includes bibliographical references (p. [189]-199) and index.
"This book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening experiments from a statistically sound basis"--Provided by publisher.
Part I. RNAi HTS and Data Analysis: 1. Introduction to Genome-Scale RNAi Research; 2. Experimental Designs; 3. Data Display and Normalization; 4. Quality Control in Genome-Scale RNAi Screens; 5. Hit Selection in Genome-Scale RNAi Screens without Replicates; 6. Hit Selection in Genome-Scale RNAi Screens with Replicates; Part II. Methodological Development for Analyzing RNAi HTS Screens: 7. Statistical Methods for Group Comparison; 8. Statistical Methods for Assessing the Size of siRNA Effects.
High throughput screening (Drug development)
Small interfering RNA.
Experimental design.