Theoretical and Applied Aspects of Systems Biology [electronic resource] /
Alves Barbosa da Silva, Fabricio.editor.(orcid)0000-0002-8172-5796https://orcid.org/0000-0002-8172-5796edt
Carels, Nicolas.editor.(orcid)0000-0003-4547-7155https://orcid.org/0000-0003-4547-7155edt
Paes Silva Junior, Floriano.editor.
Systems Biology is a rapidly expanding field and comprises the study of biological systems through mathematical modeling and the analysis of large volumes of biological data. This book presents the theoretical foundations of Systems Biology, as well as its application in studies on human hosts, pathogens and associated diseases.  This book presents several chapters written by renowned experts in the field. Some topics discussed in depth in this book include: computational modeling of multidrug-resistant bacteria, systems biology of cancer, systems immunology, cellular reprogramming, bio-modeling using Petri nets, computational modeling of neuronal circuits, reconstruction and analysis of gene regulatory networks.
PART I - Fundamentals 1  Network Theory in Computational and Systems Biology: Concepts and Applications. Marcelo Ferreira da Costa Gomes, Bruna de Paula Fonseca e Fonseca, and Tatiana Martins Tilli -- 2  In Search of an Organizing Principle in Biology: Thermodynamic Functions and Cancer. Edward Rietman and Jack A. Tuszynski -- 3  Systems Immunology. Melissa Lever, Helder I Nakaya -- 4 Mathematics and Computation for Modelling Transcriptional Regulatory Networks. Marcelo Trindade dos Santos, Ana Paula Nascimento, Fabrício A. B. Silva -- 5 Bio-modeling using Petri nets: A computational approach. Rafael Viana de Carvalho and Fons J. Verbeek -- PART II - Applied Systems Biology 6 The challenge of translating system biology in precision medicine of cancer. Alessandra Conforde, Milena Magalhães, Tatiana Tilli, Fabrício Alves, Nicolas Carels -- 7 Computational modeling of multiresistant bacteria.  Fabricio A. B. Silva, Thiago Merigueti, Thiago Giannini, Rafaela Brum, Ana Paula Nascimento, Kele Belloze, Floriano Silva, Rodolpho Albano, Marcelo Trindade dos Santos, Maria Clicia Castro, Márcio Argollo and Ana Paula D'A. Carvalho-Assef -- 8 Analysis Methods for Shotgun Metagenomics. Stephen Woloszynek, Gail Rosen, Zhengqiao Zhao, Dhantha Gunarathna , Alexandru Cristian, Joshua Chang Mell, Joshua P. Earl, Jacob Price, Christopher Sales -- 9 ANOCVA: a non-parametric statistical test to compare clustering structures. Alexandre Galvão Patriota, Davi Augusto Caetano de Jesus, and André Fujita -- 10 A path from specific enzyme to metabolic pathway modeling to access target relevance in molecular inhibitor development. Larissa Catharina Costa, Nicolas Carels, Marcio Argollo de Menezes -- 11 Mathematical-Computational Modeling in the Behavior Study of Neuronal Circuits of Repetitive Discharges. Maria Clicia Stelling de Castro, Dilson Silva, Celia Martins Cortez -- Index.  .
Systems Biology is a rapidly expanding field and comprises the study of biological systems through mathematical modeling and the analysis of large volumes of biological data. This book presents the theoretical foundations of Systems Biology, as well as its application in studies on human hosts, pathogens and associated diseases.  This book presents several chapters written by renowned experts in the field. Some topics discussed in depth in this book include: computational modeling of multidrug-resistant bacteria, systems biology of cancer, systems immunology, cellular reprogramming, bio-modeling using Petri nets, computational modeling of neuronal circuits, reconstruction and analysis of gene regulatory networks.
Bioinformatics.
Health informatics.
Cancer research.
Cell biology.
Computational Biology/Bioinformatics.
Bioinformatics.
Health Informatics.
Cancer Research.
Cell Biology.