Host Response to Biomaterials [electronic resource] : The Impact of Host Response on Biomaterial Selection
Badylak, Stephen F.
Badylak, Stephen F.Contributor
Burlington : Elsevier Science,
2015.
  Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response.   The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions.    Fiel
Description based upon print version of record.
Front Cover; Host Response to Biomaterials; Copyright Page; Contents; List of Contributors; Foreword; Preface; Acknowledgments; 1 Factors Which Affect the Host Response to Biomaterials; Introduction; Biomaterial-Host Interaction; Host Factors; Age; Nutritional Status; Anatomic Factors; Comorbidities; Obesity; Diabetes; Chemotherapy and Radiation Therapy; Design Considerations; References; 2 Perspectives on the Inflammatory, Healing, and Foreign Body Responses to Biomaterials and Medical Devices; Introduction; Blood-Material Interactions/Provisional Matrix Formation; Acute Inflammation
Chronic InflammationGranulation Tissue; Foreign Body Reaction; Fibrosis/Fibrous Encapsulation; Innate and Adaptive Immune Responses; Discussion and Perspectives; References; 3 The Biocompatibility of Implant Materials; Introduction; The Meaning of Biocompatibility; Biocompatibility: Historical Thinking; Biocompatibility Today; Toxicology; Organisms colonizing biomaterials and their impact on bioreaction; Mechanical effects; Cell-biomaterials interactions; Changing the Paradigm of Biocompatibility; Relevance to Biocompatibility; Conclusions; References
4 Host Response to Naturally Derived BiomaterialsIntroduction; The Use of Decellularized Tissue as a Biomaterial for Surgical Reconstruction and Constructive Remodeling; Immune Rejection; Decellularization Processes; α-Gal Epitope; DNA Content and Degree of Decellularization; Damage-Associated Molecular Pattern Molecules; Chemical Cross-Linking of ECM Scaffolds; Response to Individual ECM Components and Degradation Products; Degradation of Naturally Derived Biomaterials; Protease-mediated degradation; ECM fragments; Effect of Source Animal Age on Natural Biomaterial Host Response
The Host Response to ECM BiomaterialsTh1- and Th2-Lymphocyte Response; Macrophage Polarization; Conclusion; References; 5 Molecular Events at Tissue-Biomaterial Interface; General Principles Guiding Protein Interactions at the Biomaterial Interface; Introduction; Protein adsorption at the biomaterial interface; Hydrophobic interactions; Charge-charge interactions; Protein conformation changes; Protein characteristics at the biomaterial surface; Hydrophilic versus hydrophobic surfaces; Surface charge effects; The role of surface topography; Summary; Cell-Protein Interactions at the Interface
IntroductionCellular adhesion principles; Integrins; Cell adhesive proteins; Dynamic environment; Cell types involved in adhesion; Platelets; Macrophages and FBGCs; Fibroblasts and fibrotic encapsulation; Lymphocytes in the FBR; Summary; Molecular Pathways in the Regulation of Cell Activation and Cell-Cell Interactions; Introduction; Biomaterials and inflammasome activation; Macrophage priming and adhesion in the FBR; Molecular regulators of macrophage activation and fusion; JAK/STAT pathway and macrophage activation/fusion; NF-κB pathway and macrophage activation/fusion
Additional pathways in FBGC formation
  Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response.   The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions.    Fiel
Biomedical engineering.
Biomedical materials.
Regenerative medicine.
Inflammation
Biomedical and Dental Materials
Equipment and Supplies
Immune System Processes
Foreign Bodies
Investigative Techniques
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Immune System Phenomena
Chemicals and Drugs
Pathologic Processes
Manufactured Materials
Wounds and Injuries
Specialty Uses of Chemicals
Phenomena and Processes
Chemical Actions and Uses
Pathological Conditions, Signs and Symptoms
Diseases
Technology, Industry, and Agriculture
Technology, Industry, Agriculture
Transplantation Immunology
Materials Testing
Biocompatible Materials
Foreign-Body Reaction
Prostheses and Implants
Health & Biological Sciences
Biomedical Engineering