Cell Signaling Reactions [electronic resource] : Single-Molecular Kinetic Analysis /
Sako, Yasushi.editor.
Ueda, Masahiro.editor.
This book encompasses the exciting developments and challenges in the fast-moving and rapidly expanding research field of single-molecule kinetic analysis of cell signaling that promises to be one of the most significant and exciting areas of biological research for the foreseeable future. Cell signaling is carried out by complicated reaction networks of macromolecules, and single-molecule analyses has already demonstrated its power to unravel complex reaction dynamics in purified systems. To date, most of the published research in the field of single-molecule processes in cells, focus on the dynamic properties (translational movements of the centre of mass) of biological molecules. However, we hope that this book presents as many kinetic analyses of cell signaling as possible. Although single-molecule kinetic analysis of cellular systems is a relatively young field when compared with the analysis of single-molecule movements in cells, this type of analysis is highly important because it directly relates to the molecular functions that control cellular behavior and in the future, single-molecule kinetic analysis will be largely directed towards cellular systems. Thus, we hope that this book will be of interest to all those working in the fields of molecular and cell biology, as well as biophysics and biochemistry.
Description based upon print version of record.
Cell Signaling Reactions; Preface; Contents; Contributors; Chapter 1: Single-Molecule Kinetic Analysis of Receptor Protein Tyrosine Kinases; Chapter 2: Single-Molecule Kinetic Analysis of Stochastic Signal Transduction Mediated by G-Protein Coupled Chemoattractant Receptors; Chapter 3: Single-Molecule Analysis of Molecular Recognition Between Signaling Proteins RAS and RAF; Chapter 4: Single-Channel Structure-Function Dynamics: The Gating of Potassium Channels
Chapter 5: Immobilizing Channel Molecules in Artificial Lipid Bilayers for Simultaneous Electrical and Optical Single Channel RecordingsChapter 6: Single-Protein Dynamics and the Regulation of the Plasma-Membrane Ca2+ Pump; Chapter 7: Single-Molecule Analysis of Cell-Virus Binding Interactions; Chapter 8: Visualization of the COPII Vesicle Formation Process Reconstituted on a Microscope; Chapter 9: In Vivo Single-Molecule Microscopy Using the Zebrafish Model System; Chapter 10: Analysis of Large-Amplitude Conformational Transition Dynamics in Proteins at the Single-Molecule Level
Chapter 11: Extracting the Underlying Unique Reaction Scheme from a Single-Molecule Time SeriesChapter 12: Statistical Analysis of Lateral Diffusion and Reaction Kinetics of Single Molecules on the Membranes of Living Cells; Chapter 13: Noisy Signal Transduction in Cellular Systems; Index
Includes bibliographical references and index.
This book encompasses the exciting developments and challenges in the fast-moving and rapidly expanding research field of single-molecule kinetic analysis of cell signaling that promises to be one of the most significant and exciting areas of biological research for the foreseeable future. Cell signaling is carried out by complicated reaction networks of macromolecules, and single-molecule analyses has already demonstrated its power to unravel complex reaction dynamics in purified systems. To date, most of the published research in the field of single-molecule processes in cells, focus on the dynamic properties (translational movements of the centre of mass) of biological molecules. However, we hope that this book presents as many kinetic analyses of cell signaling as possible. Although single-molecule kinetic analysis of cellular systems is a relatively young field when compared with the analysis of single-molecule movements in cells, this type of analysis is highly important because it directly relates to the molecular functions that control cellular behavior and in the future, single-molecule kinetic analysis will be largely directed towards cellular systems. Thus, we hope that this book will be of interest to all those working in the fields of molecular and cell biology, as well as biophysics and biochemistry.
Medicine.
Cell biology.
Biochemistry.
Biomedicine, general.
Cell Biology.
Biochemistry, general.