Notch Regulation of the Immune System [electronic resource] /
Radtke, Freddy.editor.
Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This volume of Current Topics in Microbiology and Immunology covers divers topics of Notch function within the immune system.  The review series starts with an overview on the role of Notch function for the generation, and specification of hematopoietic stem cells during mouse development and adulthood. Chapters follow describing molecular players and specific functions of Notch during T cell lineage commitment and maturation in both mouse and human. Once T cell development is accomplished and T cells have been positively and negatively selected, they migrate from the thymus to the periphery. There they regulate host defense to pathogens as well as immune homeostasis, which is described in two chapters of this series. A subsequent report summarizes recent findings suggesting a role of Notch in regulating alloreactive T cell immunity. This process mediates recognition of foreign antigens in recipients of organ transplants. The family of Notch receptors consists of four family members (Notch1-4). Some aspects of Notch function in immunity are regulated by single others by multiple receptors. One review of this series describes the specific function of Notch2 during hematopoietic lineage specification and immune function. The last chapter is dedicated to the oncogenic properties of NOTCH1 in T cell acute lymphoblastic leukemia (T-ALL) and potential avenues of targeting NOTCH1 therapeutically. Collectively these reviews summarize the pleiotropic functions of Notch in immunity and there is undoubtedly more to come in the future.
Description based upon print version of record.
Notch Regulationof the Immune System; Preface; Contents; Contributors; 229 The Notch Pathway in Hematopoietic Stem Cells; Abstract; 1...The Basics of the Notch Signaling Pathway; 2...HSC Generation in the Embryo; 2.1 Different Waves of Hematopoietic Differentiation Occur During Embryonic Life; 2.2 Origin of HSCs: Hemangioblast, Hemogenic Endothelium, Arterial Endothelium, or Mesodermal Endothelial-like Precursor; 2.3 Notch is Dispensable to Generate Primitive or Transient Definitive Hematopoietic Cells; 2.4 Hematopoietic Waves Occurring in Embryonic Stem-Cell Cultures
2.5 Notch is Required for HSC Generation3...Adult Hematopoietic Stem Cells and Progeny; 3.1 Self-Renewal of HSC and Asymmetric Cell Division: A Role for Notch?; 3.2 Notch is not Required for Adult Bone Marrow HSC Maintenance In Vivo; 3.3 Notch Activation Results in Expansion of Hematopoietic Progenitors; 3.4 Notch in Hematopoietic Differentiation and Hematologic Disorders; 3.5 Leukemia Initiating Cells: A Role for Notch?; 4...Conclusions; Acknowledgments; References; 225 Notch Receptor-Ligand Interactions During T Cell Development, a Ligand Endocytosis-Driven Mechanism; Abstract
1...T Cell Development2...The Notch Signaling Pathway; 3...Notch Receptors; 4...DSL Notch Ligands; 5...Notch Ligand Endocytosis; 5.1 Neuralized and Mindbomb; 5.2 Other Molecules Involved in Endocytosis; 5.3 Models Proposed for Ligand Endocytosis; 5.3.1 The Mechanotransduction Model; 5.3.2 The Recycling Model; 6...Modulators of Notch Signaling; 7...Notch Signaling and T Cell Development; 7.1 Notch Receptor Expression in the Thymus; 7.2 Notch Ligand Expression in the Thymus; 7.3 Notch Ligand Endocytosis and Role in T Cell Development; 7.4 Notch Modulators and T Cell Development; 8...Summary; References
231 Notch1 and IL-7 Receptor Signalling in Early T-cell Development and LeukaemiaAbstract; 1...From Early Thymic Progenitors to Mature T Cells; 1.1 Two Intrathymic Checkpoints for Cellular Expansion of Developing T Cells; 1.2 IL-7R Expression Marks a Lymphoid/Myeloid Developmental Split in Human Thymopoiesis; 2...IL-7R Signalling in Early T-cell Development; 3...Notch Regulation of Early Thymocyte Development; 3.1 Notch1 Activation Diverts Early Thymic Progenitors from Alternative Cell Fates and Promotes Cell Growth
3.2 Notch1 Signalling Controls T-Lineage-Specific IL-7R Expression in Early Thymopoiesis4...Notch1 Signalling in T-ALL; 4.1 Notch1 and IL-7R: Independent or Complementary Pathways in T-ALL?; 5...Conclusions; Acknowledgments; References; 230 Notch Signaling During Human T cell Development; Abstract; 1...Human T cell Development; 2...Notch Signaling Profile; 3...Stage-Specific Notch Signaling Requirements; 3.1 Induction Of T-Lineage Specification; 3.2 Induction Of T-Cell Commitment; 3.3 TCR Rearrangements, beta -Selection and Beyond; 4...TCR- alpha beta Versus TCR- gamma delta Lineage Choice; 5...Conclusion
Acknowledgments
Includes bibliographical references and index.
Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This volume of Current Topics in Microbiology and Immunology covers divers topics of Notch function within the immune system.  The review series starts with an overview on the role of Notch function for the generation, and specification of hematopoietic stem cells during mouse development and adulthood. Chapters follow describing molecular players and specific functions of Notch during T cell lineage commitment and maturation in both mouse and human. Once T cell development is accomplished and T cells have been positively and negatively selected, they migrate from the thymus to the periphery. There they regulate host defense to pathogens as well as immune homeostasis, which is described in two chapters of this series. A subsequent report summarizes recent findings suggesting a role of Notch in regulating alloreactive T cell immunity. This process mediates recognition of foreign antigens in recipients of organ transplants. The family of Notch receptors consists of four family members (Notch1-4). Some aspects of Notch function in immunity are regulated by single others by multiple receptors. One review of this series describes the specific function of Notch2 during hematopoietic lineage specification and immune function. The last chapter is dedicated to the oncogenic properties of NOTCH1 in T cell acute lymphoblastic leukemia (T-ALL) and potential avenues of targeting NOTCH1 therapeutically. Collectively these reviews summarize the pleiotropic functions of Notch in immunity and there is undoubtedly more to come in the future.
Immunology.
Immunology.
Current topics in microbiology and immunology