Natural Compounds as Drugs, Volume I [electronic resource] /
Petersen, Frank.editor.
Amstutz, René.editor.
The use of drug substances derived from plants, fungi, bacteria, and marine organisms has a long tradition in medicine. Together with their derivatives, and synthetic compounds deduced from natural product precursors, they represent a major part of today's pharmaceutical market. Within the fast developing discipline of molecular biology, natural products also play an important role as tool compounds in pathway screening and validation of target identification concepts. They provide innovative opportunities in drug discovery, leading to a detailed understanding of biological pathways and revealing the functions of involved enzymes or receptors. This book highlights new trends and aspects in natural products research. It discusses the biodiversity-driven approaches which are now of eminent importance in natural products research, addressing the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.
Description based upon print version of record.
Includes bibliographical references and index.
Mother Nature’s gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery -- Drug discovery and development with plant-derived compounds -- Evolutionary mechanisms underlying secondary metabolite diversity -- Biodiversity, chemical diversity and drug discovery -- High impact technologies for natural products screening -- Virtual screening for the discovery of bioactive natural products -- Strain improvement for production of pharmaceuticals and other microbial metabolites by fermentation -- Nutritional and engineering aspects of microbial process development -- Natural products from plant cell cultures.
The use of drug substances derived from plants, fungi, bacteria, and marine organisms has a long tradition in medicine. Together with their derivatives, and synthetic compounds deduced from natural product precursors, they represent a major part of today's pharmaceutical market. Within the fast developing discipline of molecular biology, natural products also play an important role as tool compounds in pathway screening and validation of target identification concepts. They provide innovative opportunities in drug discovery, leading to a detailed understanding of biological pathways and revealing the functions of involved enzymes or receptors. This book highlights new trends and aspects in natural products research. It discusses the biodiversity-driven approaches which are now of eminent importance in natural products research, addressing the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.
Pharmacology.
Biochemistry.
Pharmacology/Toxicology.
Biochemistry, general.