Neurogenesis in the Adult Brain I [electronic resource] : Neurobiology /
Seki, Tatsunori.editor.
Sawamoto, Kazunobu.editor.
Parent, Jack M.editor.
Alvarez-Buylla, Arturo.editor.
The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.
Description based upon print version of record.
Neurogenesis in the Adult Brain I; Preface; Contents; Contents of Volume II; Contributors; Part I: History; Chapter 1: The Discovery of Adult Mammalian Neurogenesis*; 1.1 Serendipity; 1.2 Systematic Investigation of Postnatal and Adult Gliogenesis and Neurogenesis; 1.2.1 From Exploratory to Systematic Investigations of Postnatal Neurogenesis; 1.2.2 Hippocampal Granule Cell Hypoplasia Produced by X-Irradiation; 1.2.3 Behavioral Effects of Hippocampal Granule Cell Hypoplasia; 1.2.4 Postnatal and Adult Neurogenesis in the Neocortex and the Olfactory Bulb
1.2.5 The Relationship Between Prenatal and Postnatal Neurogenesis1.3 Peer Reactions: Initial Excitement, Followed by Marginalization and Subsequent Disqualification; 1.3.1 A Short Period of Excitement; 1.3.2 Marginalization; 1.3.3 Disqualification; 1.4 Prospering Under Adverse Conditions and Switching to the Comprehensive Study of CNS Development; 1.5 The Changed Paradigm in the Study of Adult Neurogenesis; References; Chapter 2: Song Learning in Birds Offers a Model for Neuronal Replacement in Adult Brain; 2.1 The Study of Vocal Learning; 2.2 Two Sound Sources and Left Hemispheric Dominance
2.3 The Song System2.4 Sexual Dimorphism; 2.5 The Late Ontogeny of the Song System; 2.6 Brain Seasonal Changes; 2.7 Space for Learning and Memory; 2.8 Always the Same Neurons?; 2.9 3H-Labeled Cells in Adult HVC; 2.10 Hope for a New Neurology; 2.11 The Role of Joseph Altman; 2.12 Are They Really Adult-Born Neurons?; 2.13 Birth and Migration of New Neurons; 2.14 Neuronal Stem Cells; 2.15 The Relation Between Behavior, Adult Neurogenesis and Neuronal Replacement; 2.16 Use and Disuse as Regulators of New Neuron Survival; 2.17 New Neurons as a Vehicle for Learning
2.18 Manipulations of Learning Load Alter New Neuron Recruitment2.19 Evidence from Other Songbird Systems; 2.20 Overview; References; Part II: Basic Aspects of Neurogenesis; Chapter 3: Fate Specification of Neural Stem Cells; 3.1 Introduction; 3.2 Molecular Mechanisms Regulating Neuronal Fate; 3.2.1 Neurogenic bHLH; 3.2.2 Epigenetic Modification in Neuronal Differentiation of NSCs; 3.2.2.1 Chromatin Modification; 3.2.2.2 ncRNA; 3.3 Molecular Mechanisms Regulating Glial Fates; 3.3.1 Astrocytes; 3.3.1.1 Signaling Pathways Promoting Astroglial Fate
3.3.1.2 Transcription Factors Inducing Astrogenesis3.3.1.3 Epigenetic Modification Regulating Astrocyte Differentiation; 3.3.2 Oligodendrocytes; 3.3.2.1 Signaling Pathways Regulating Oligodendroglial Fate; 3.3.2.2 Transcription Factors Regulating Oligodendrocyte Differentiation; 3.4 Closing Remarks; References; Chapter 4: Fractones: Home and Conductors of the Neural Stem Cell Niche; 4.1 Introduction to the Concept of the Neural Stem Cell Niche; 4.2 The Discovery of Fractones; 4.3 Fractone Composition and Distribution in the Adult Brain
4.4 A Highly Organized Fractone and Vascular Niche for Neurogenesis
Includes bibliographical references and index.
The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.
Neurosciences.
Cell biology.
Neurobiology.
Neurosciences.
Cell Biology.
Neurobiology.