Intestinal Tumorigenesis [electronic resource] : Mechanisms of Development & Progression /
Yang, Vincent W.editor.
Bialkowska, Agnieszka B.editor.
This volume includes the information necessary to understand recent critical advances in the mechanisms of intestinal tumorigenesis and to comprehend the complexity of the process. The volume aims to entice new researchers to participate in relevant studies, and to provide a forum for discussion within the scientific community to shape future research in this field. Discoveries in intestinal tumorigenesis lead to further understanding of mechanisms involved in colon cancer. Additionally, advancements in techniques and methods open the doors for new approaches to better define the molecular and organismal mechanisms of intestinal tumorigenesis. Chapters are authored by widely published authorities in the field. Each year, there are close to 150,000 new cases of colorectal cancer, which results in approximately 50,000 deaths per year in the United States; these figures render colorectal cancer a significant health concern. Studies attempting to understand the mechanisms of development and progression of colorectal cancer have been ongoing for decades and each year brings new discoveries yielding a better comprehension of the underlying processes at work.
Description based upon print version of record.
Preface; Contents; Contributors; Hereditary CRC Syndromes; 1 Introduction; 2 Nonpolyposis Syndromes; 2.1 Lynch Syndrome (Hereditary Nonpolyposis Colon Cancer); 2.1.1 Genetics and Molecular Mechanisms; 2.1.2 Epidemiology and Clinical Presentation; 2.1.3 Diagnosis; 2.1.4 Surveillance and Cancer Prevention; 2.1.5 Cancer Management; 3 Polyposis Syndromes; 3.1 Familial Adenomatous Polyposis (FAP) and Attenuated Familial Adenomatous Polyposis (AFAP); 3.1.1 Genetics and Molecular Mechanisms; 3.1.2 Epidemiology and Clinical Presentation; 3.1.3 Diagnosis; 3.1.4 Surveillance and Cancer Prevention
3.1.5 Cancer Management3.2 MUTYH-associated Polyposis; 3.2.1 Genetics and Molecular Mechanisms; 3.2.2 Epidemiology and Clinical Presentation; 3.2.3 Diagnosis; 3.2.4 Cancer Surveillance; 3.3 Juvenile Polyposis Syndrome; 3.3.1 Genetics and Molecular Mechanisms; 3.3.2 Epidemiology and Clinical Presentation; 3.3.3 Diagnosis; 3.3.4 Cancer Surveillance; 3.4 Peutz-Jeghers Syndrome; 3.4.1 Genetics and Molecular Mechanisms; 3.4.2 Epidemiology and Clinical Presentation; 3.4.3 Diagnosis; 3.4.4 Cancer Surveillance; 3.5 PTEN Hamartoma Syndromes; 3.5.1 Genetics and Molecular Mechanisms
3.5.2 Epidemiology and Clinical Presentation3.5.3 Diagnosis; 3.5.4 Cancer Surveillance; 3.6 Serrated Polyposis Syndrome; 3.6.1 Genetics and Molecular Mechanisms; 3.6.2 Epidemiology and Clinical Presentation; 3.6.3 Diagnosis; 3.6.4 Cancer Surveillance; 4 Conclusion; References; Microsatellite Instability and Intestinal Tumorigenesis; 1 Microsatellite Instability and Mismatch Repair; 1.1 Microsatellites; 1.2 Mismatch Repair; 1.3 Microsatellite Instability; 2 Mouse Models of Mismatch Repair; 2.1 MutS Homolog Deficient Mice; 2.2 MSH2; 2.3 MSH6; 2.4 MSH3; 2.5 MutL Homolog Deficient Mice; 2.6 MLH1
2.7 PMS22.8 MLH3; 2.9 Exonuclease 1; 2.10 Homozygous MMR Mutant Mice with Heterozygous Adenomatous polyposis coli (APC) Mutation; 3 Microsatellite Instability in Human Cancers; 3.1 Lynch Syndrome or germline mutations in MMR genes; 3.2 Sporadic MSI; 3.3 Constitutional Epimutations; 3.4 Lynch-Like Syndrome; 4 Testing for MSI; 4.1 Microsatellite instability PCR testing; 4.2 MSI testing of colon polyps; 4.3 Immunohistochemistry; 4.4 Hypermethylation Testing; 4.5 Genetic Testing; 4.6 Classifying CRC by molecular features; 5 Clinical Implications of MSI in the Large Bowel, Small Bowel and Stomach
5.1 Microsatellite Instability in Colorectal Cancer5.2 Microsatellite Stable Colorectal Cancer: Familial Colorectal Cancer Type X; 5.3 MSI in Small Bowel Cancer; 5.4 MSI in Gastric Cancer; References; Biology of Intestinal Epithelial Stem Cells; 1 Structure of the Adult Intestines; 2 Stem Cells in the Intestinal Epithelium; 3 Locating the Intestinal Stem Cell (ISC); 4 Marking the Intestinal Stem Cell; 5 A Stem Cell Hierarchy; 6 Progeny of Intestinal Stem Cells; 6.1 Absorptive Versus Secretory Cell Fate; 6.2 The Absorptive Enterocyte; 6.2.1 M Cells; 6.2.2 Cup Cells; 6.3 Secretory Cells
6.3.1 Enteroendocrine Cells
Includes bibliographical references at the end of each chapters and index.
This volume includes the information necessary to understand recent critical advances in the mechanisms of intestinal tumorigenesis and to comprehend the complexity of the process. The volume aims to entice new researchers to participate in relevant studies, and to provide a forum for discussion within the scientific community to shape future research in this field. Discoveries in intestinal tumorigenesis lead to further understanding of mechanisms involved in colon cancer. Additionally, advancements in techniques and methods open the doors for new approaches to better define the molecular and organismal mechanisms of intestinal tumorigenesis. Chapters are authored by widely published authorities in the field. Each year, there are close to 150,000 new cases of colorectal cancer, which results in approximately 50,000 deaths per year in the United States; these figures render colorectal cancer a significant health concern. Studies attempting to understand the mechanisms of development and progression of colorectal cancer have been ongoing for decades and each year brings new discoveries yielding a better comprehension of the underlying processes at work.
Cancer research.
Molecular biology.
Cell biology.
Cancer Research.
Molecular Medicine.
Cell Biology.