Myocardial Tissue Engineering [electronic resource] /
Boccaccini, Aldo R.editor.
Harding, Sian.editor.
Myocardial tissue engineering (MTE), a strategy that uses materials or material/cell constructs to prolong patients’ life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered ‘vehicle’, which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book also considers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE.
Description based upon print version of record.
Myocardial Tissue Engineering; Preface; References; Contents; 82 Tissue Engineering for Cardiac Regeneration; Abstract; 1...Introduction; 2...Cardiac Tissue Engineering for Heart Regeneration; 3...Survival and Engraftment of Transplanted Cell: Strategies to Improve Myocardial Regeneration; 4...The Importance of Extracellular Matrix; 5...Natural ECM for CTE Application; 5.1 Fibrin Scaffold; 5.2 Collagen Scaffold; 5.3 Hyaluronic Acid; 5.4 Alginate; 5.5 Engineered Heart Tissue; 6...Building a Cardiac Tissue without ECM Components: Cell-Sheet Based Engineering; 7...Tissue Derived Extracellular Matrix
8...Synthetic Extracellular Matrix for Cardiac Tissue Engineering9...Conclusion; References; 58 Inherently Bio-Active Scaffolds: Intelligent Constructs to Model the Stem Cell Niche; Abstract; 1...Introduction; 2...Towards a Paradigm Shift; 3...Who and Where are the Stem Cells?; 4...Unstable Niches; 5...Engineering Factors Which Determine Phenotype; 6...Current Material-Based Cardiac Regeneration Strategies; 7...Smart Materials Strategies: The IBAS Concept; 8...Conclusion; References; 90 Strategies for Myocardial Tissue Engineering: The Beat Goes On; Abstract; 1...Background and Clinical Demand
1.1 Adult Cardiac Disease1.2 Congenital Cardiac Disease; 1.3 In Vitro Drug Testing; 2...Current Strategies in Myocardial Tissue Engineering; 2.1 Myocardial Tissue Engineering According to the Traditional Paradigm; 2.1.1 Tissue Engineering Based on Solid Scaffolds; Synthetic Scaffold Materials; Biological Scaffold Materials; Decellularized Biological Scaffolds; 2.1.2 Tissue Engineering with Liquid- and Gel-Based Scaffolds; 2.2 Guided Tissue Regeneration; 2.3 Starter Matrix-Free Myocardial Tissue Engineering; 2.4 Alternative Concepts; 3...Current Problems
3.1 The Seemingly Endless Search for the Ideal Cell Source3.2 At the Crossroad: The Vital Importance of Establishing a Functional Vascular Network; 3.3 Out of Our Hands: How to Control the Fate of a Tissue Engineered Graft After Implantation?; References; 40 Creating Unique Cell Microenvironments for the Engineering of a Functional Cardiac Patch; Abstract; 1...Introduction; 2...Improving In Vitro Mass Transfer by the Use of Perfusion Bioreactors; 2.1 Perfusion Bioreactors for Cardiac Tissue Engineering; 3...Prevascularization of Engineered Tissues; 3.1 Engineering Microvascular Networks
3.2 Capillary Formation within Engineered Tissues by Ex Vivo Co-Cultures3.3 The Body as a Bioreactor for Vascularization; 4...Concluding Remarks; References; 45 Intramyocardial Stem Cell Transplantation Without Tissue Engineered Constructs: The Current Clinical Situation; Abstract; 1...Introduction; 2...Background for Intramyocardial Stem Cell Transplantation in Cardiac Surgery; 3...Cell Types for Intramyocardial Stem Cell Transplantation; 3.1 Skeletal Myoblasts; 3.2 Bone Marrow Hematopoetic Progenitor/Stem Cells; 3.3 Mesenchymal Stem Cells from the Bone Marrow
4...Stem Cell Isolation and Mode of Delivery
Includes bibliographical references and index.
Myocardial tissue engineering (MTE), a strategy that uses materials or material/cell constructs to prolong patients’ life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered ‘vehicle’, which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book also considers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE.
Biomedical engineering.
Stem cells.
Biomaterials.
Gene therapy.
Cardiology.
Biomedical Engineering and Bioengineering.
Stem Cells.
Biomaterials.
Gene Therapy.
Cardiology.
Studies in Mechanobiology, Tissue Engineering and Biomaterials