Signaling Pathways in Squamous Cancer [electronic resource] /
Glick, Adam B.editor.
Waes, Carter Van.editor.
Squamous epithelia form the essential lining surface of tissues in contact with the environment, including the skin, and mucosa of the oral cavity, pharynx, larynx, esophagus, respiratory and genital tracts, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV light, tobacco smoke, and infectious agents. Consequently, squamous cell carcinomas that form in these tissues are among the most common human solid tumors, and have high morbidity and mortality. The signaling pathways that regulate epithelial homeostasis and the alterations in these pathways that arise during cancer development share certain features among these different tissue sites. This book brings together timely reviews from experts in the field on mechanisms and signaling pathways such as EGFR, TGF1, NFB, PPARs and mTOR/AKT that regulate development of squamous cancer in both human and experimental mouse models, with a focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy. This comprehensive monograph will be important for researchers wishing to enter the field, for medical students, and for established basic and clinical investigators who would gain from an overview of the field.
Description based upon print version of record.
Signaling Pathways in Squamous Cancer; Preface; Acknowledgments; Contents; Contributors; Chapter 1: Cell Adhesion Molecules in Carcinoma Invasion and Metastasis; Chapter 2: Roles of Integrins in the Development and Progression of Squamous Cell Carcinomas; Chapter 3: Alterations of Transforming Growth Factor-b Signaling in Squamous Cell Carcinomas; Chapter 4: Aberrant Activation of HGF/c-MET Signaling and Targeted Therapy in Squamous Cancer; Chapter 5: The Epidermal Growth Factor Receptor in Normal and Neoplastic Epithelia; Chapter 6: Cyclooxygenase-2 Signaling in Squamous Cell Carcinomas
Chapter 7: Interacting Signaling Pathways in Mouse Skin Tumor Initiation and ProgressionChapter 8: Protein Kinase C and the Development of Squamous Cell Carcinoma; Chapter 9: The Transcription Factor AP-1 in Squamous Cell Carcinogenesis: Lessons from Mouse Models of Skin Carcinogenesis; Chapter 10: NF-kB, IkB Kinase and Interacting Signal Networks in Squamous Cell Carcinomas; Chapter 11: Regulation of Squamous Cell Carcinoma Carcinogenesis by Peroxisome Proliferator-Activated Receptors; Chapter 12: p63 in Squamous Differentiation and Cancer
Chapter 13: Effects of Natural and Synthetic Retinoids on the Differentiation and Growth of Squamous CancersChapter 14: Regulation of Keratinocyte Differentiation by Vitamin D and Its Relationship to Squamous Cell Carcinoma; Chapter 15: Epidermal Growth Factor Receptor-Targeted Therapies; Chapter 16: Targeting UVB Mediated Signal Transduction Pathways for the Chemoprevention of Squamous Cell Carcinoma; Chapter 17: Molecular-Targeted Chemotherapy for Head and Neck Squamous Cell Carcinoma
Chapter 18: Effects and Therapeutic Potential of Targeting Dysregulated Signaling Axes in Squamous Cell Carcinoma: Another Kinase of Transcription and Mammalian Target of RapamycinChapter 19: Head and Neck Cancer and the PI3K/Akt/mTOR Signaling Network: Novel Molecular Targeted Therapies; Chapter 20: High Throughput Molecular Profiling Approaches for the Identifications of Genomic Alterations and Therapeutic Targets in Oral Cancer; Index
Includes bibliographical references and index.
Squamous epithelia form the essential lining surface of tissues in contact with the environment, including the skin, and mucosa of the oral cavity, pharynx, larynx, esophagus, respiratory and genital tracts, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV light, tobacco smoke, and infectious agents. Consequently, squamous cell carcinomas that form in these tissues are among the most common human solid tumors, and have high morbidity and mortality. The signaling pathways that regulate epithelial homeostasis and the alterations in these pathways that arise during cancer development share certain features among these different tissue sites. This book brings together timely reviews from experts in the field on mechanisms and signaling pathways such as EGFR, TGF1, NFB, PPARs and mTOR/AKT that regulate development of squamous cancer in both human and experimental mouse models, with a focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy. This comprehensive monograph will be important for researchers wishing to enter the field, for medical students, and for established basic and clinical investigators who would gain from an overview of the field.
Cancer research.
Pharmacology.
Cancer Research.
Pharmacology/Toxicology.