Yeast as a Tool in Cancer Research [electronic resource] /
Nitiss, John L.editor.
Heitman, Joseph.editor.
Leland H. Hartwell Director, Fred Hutchinson Cancer Research Center, Nobel Laureate for Medicine, 2001 Yeast has proved to be the most useful single-celled organism for studying the fundamental aspects of cell biology. Resources are now available for yeast that greatly simplify and empower new investigations, like the presence of strains with each gene deleted, each protein tagged and databases on protein-protein interactions, gene regulation, and subcellular protein location. A powerful combination of genetics, cell biology, and biochemistry employed by thousands of yeast researchers has unraveled the complexities of numerous cellular processes from mitosis to secretion and even uncovered new insights into prion diseases and the role of prions in normal biology. These insights have proven, time and again, to foretell the roles of proteins and pathways in human cells. The collection of articles in this volume explores the use of yeast in pathway analysis and drug discovery. Yeast has, of course, supplied mankind's most ubiquitous drug for thousands of years. In one aspect, the role of yeast in drug discovery is much like the role of yeast in other areas of biology. Yeast offers the power of genetics and a repetoire of resources available in no other organism. Using yeast in the study of drug targets and metabolism can help to make a science of what has been largely an empirical activity. A science of drug discovery would permit rigorous answers to important questions.
Description based upon print version of record.
From DNA Replication to Genome Instability in Schizosaccharomyces Pombe: Pathways to Cancer -- Dissecting Layers of Mitotic Regulation Essential for Maintaining Genomic Stability -- Yeast as a Tool in Cancer Research: Nuclear Trafficking -- Studies of Protein Farnesylation in Yeast -- From Bread to Bedside: What Budding Yeast has Taught us about the Immortalization of Cancer Cells -- HSP90 Co-Chaperones in Saccharomyces Cerevisiae -- Yeast as a Model System for Studying Cell Cycle Checkpoints -- Metabolism and Function of Sphingolipids in Saccharomyces Cerevisiae: Relevance to Cancer Research -- Exploring and Restoring the p53 Pathway Using the p53 Dissociator Assay in Yeast -- Functional Analysis of the Human p53 Tumor Suppressor and its Mutants Using Yeast -- ABC Transporters in Yeast - Drug Resistance and Stress Response in a Nutshell -- The FHCRC/NCI Yeast Anticancer Drug Screen -- Yeast as a Model to Study the Immunosuppressive and Chemotherapeutic Drug Rapamycin -- Use of Yeast as a Model System for Identifying and Studying Anticancer Drugs -- Genetic Analysis of Cisplatin Resistance in Yeast and Mammals -- Using Yeast Tools to Dissect the Action of Anticancer Drugs: Mechanisms of Enzyme Inhibition and Cell Killing by Agents Targeting DNA Topoisomerases.
Leland H. Hartwell Director, Fred Hutchinson Cancer Research Center, Nobel Laureate for Medicine, 2001 Yeast has proved to be the most useful single-celled organism for studying the fundamental aspects of cell biology. Resources are now available for yeast that greatly simplify and empower new investigations, like the presence of strains with each gene deleted, each protein tagged and databases on protein-protein interactions, gene regulation, and subcellular protein location. A powerful combination of genetics, cell biology, and biochemistry employed by thousands of yeast researchers has unraveled the complexities of numerous cellular processes from mitosis to secretion and even uncovered new insights into prion diseases and the role of prions in normal biology. These insights have proven, time and again, to foretell the roles of proteins and pathways in human cells. The collection of articles in this volume explores the use of yeast in pathway analysis and drug discovery. Yeast has, of course, supplied mankind's most ubiquitous drug for thousands of years. In one aspect, the role of yeast in drug discovery is much like the role of yeast in other areas of biology. Yeast offers the power of genetics and a repetoire of resources available in no other organism. Using yeast in the study of drug targets and metabolism can help to make a science of what has been largely an empirical activity. A science of drug discovery would permit rigorous answers to important questions.
Cancer research.
Pharmacology.
Biotechnology.
Cancer Research.
Pharmacology/Toxicology.
Biotechnology.