Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach [electronic resource] /
De Ponte, Francesco Saverio.editor.
Bisphosphonates are commonly prescribed to inhibit bone loss in patients with osteoporosis, as well as osteopenia, cancer, and Paget's disease of the bone. Recently, scientific literature has addressed a possible relationship between bisphosphonates and osteonecrosis of the jaw (ONJ). It is important to note that though the risks for developing ONJ are much higher for cancer patients on intravenous bisphosphonate therapy (used to reduce bone pain), the occurrence of ONJ also in patients treated with oral BF for osteoporosis has been also highlighted, though rarely. On the basis of the large use of BF, of their pharmacokinetics, of the systemic and local risk factors, physicians prescribing them and dental surgeons should be well informed on the various aspects of the problem. Aim of this volume is to offer an update on the current status of prevention, and on the current conservative and surgical treatments. The multidisciplinary approach will be very much appreciated by GP's, the different specialists using bisphosphonates and by dental surgeons.
Description based upon print version of record.
Bisphosphonates and Osteonecrosis of the Jaw:A Multidisciplinary Approach; Foreword; Contents; Contributors; 1 Introduction; Abstract; 1.1...Introduction; 1.2...The Phossy Jaw Epidemic of sim1850--1906; 1.3...Correcting the Incorrect Terminology; 1.4...Conclusions; References; 2 Pharmacology: Mechanism of Action of Bisphosphonates; Abstract; 2.1...Introduction; 2.2...Chemical Structure; 2.3...Mechanism of Action and Pharmacodynamics; 2.4...Pharmacokinetics; 2.5...Adverse Effects; Acknowledgment; References; 3 Use of Bisphosphonates in Oncology; Abstract; 3.1...Introduction; 3.2...Bisphosphonates in Bone Metastasis
3.3...Breast Cancer3.4...Prostate Cancer; 3.5...Other Tumors: Lung, Kidney, Bladder and Thyroid; 3.6...Conclusions; References; 4 Use of Bisphosphonates in Hematology; Abstract; 4.1...Introduction; 4.2...Adverse Effects of Bisphosphonates; 4.2.1 Epidemiology and Pathogenesis; 4.3...The Use of Bisphosphonates in Multiple Myeloma; 4.4...Bisphosphonates and Hematology: Not Only Multiple Myeloma; 4.4.1 Bisphosphonates and Hematopoietic Cell Transplantation; 4.4.2 Bisphosphonate and Hypercalcemia; 4.5...Anti-tumor Effects of Bisphosphonates in Multiple Myeloma; 4.6...Conclusions; References
5 Use of Bisphosphonates in OsteoporosisAbstract; 5.1...Introduction; 5.2...Bisphosphonates in Osteoporosis; 5.3...Clinical Efficacy and Safety of Bisphosphonates; 5.4...Conclusions; Acknowledgement; References; 6 Biomorphology in BIONJ: Anatomy and Histology; Abstract; 6.1...The Jaw; 6.2...The Jaw Ramii; 6.3...Histology; 6.4...Bone Remodeling and Osteonecrosis; References; 7 Etiopathogenesis and Clinical Aspects of BIONJ; Abstract; 7.1...Etiopathogenesis of BIONJ; 7.2...Bisphosphonate-Related Risk Factors; 7.2.1 Local Risk Factors; 7.2.2 Predisposing Factors; 7.3...Clinical Aspects of BIONJ; References
8 Instrumental DiagnosisAbstract; 8.1...Introduction; 8.2...Panoramic Radiograph and CT; 8.3...Magnetic Resonance Imaging; 8.4...Functional Imaging; 8.5...Differential Diagnosis; 8.6...Conclusions; References; 9 Microbiological Aspects of Osteonecrosis of the Jaw; Abstract; 9.1...Introduction; 9.2...Infection and Stage 0 Disease; 9.2.1 The Specific Role of Actinomyces; 9.3...Biofilms and BIONJ; 9.4...Conclusions; References; 10 Prevention and the Role of the Dentist; Abstract; 10.1...Introduction; 10.2...Diagnostic Considerations; 10.3...Clinical and Radiographic Features of BIONJ
10.4...Risk Factors in the Development of BIONJ10.5...Preventive Measures in Oncologic Patients; 10.6...Preventive Measures in Osteoporosis Patients; 10.7...Value of Biochemical Markers of Metabolic Bone Activity; 10.8...Concluding Remarks; References; 11 Conservative Treatment: Oxygen-Ozone Therapy; Abstract; 11.1...Introduction; 11.2...Oxygen Therapy; 11.3...Ozone Therapy; 11.3.1 Ozone Protocol; References; 12 Conservative Treatment: LASER (Biostimulation and Minimally Invasive Surgical Treatment); Abstract; 12.1...Introduction; 12.2...Low Level Laser Therapy; 12.3...Minimally Invasive Laser Surgery
12.4...Laser and Preventive Measures
Includes bibliographical references and index.
Bisphosphonates are commonly prescribed to inhibit bone loss in patients with osteoporosis, as well as osteopenia, cancer, and Paget's disease of the bone. Recently, scientific literature has addressed a possible relationship between bisphosphonates and osteonecrosis of the jaw (ONJ). It is important to note that though the risks for developing ONJ are much higher for cancer patients on intravenous bisphosphonate therapy (used to reduce bone pain), the occurrence of ONJ also in patients treated with oral BF for osteoporosis has been also highlighted, though rarely. On the basis of the large use of BF, of their pharmacokinetics, of the systemic and local risk factors, physicians prescribing them and dental surgeons should be well informed on the various aspects of the problem. Aim of this volume is to offer an update on the current status of prevention, and on the current conservative and surgical treatments. The multidisciplinary approach will be very much appreciated by GP's, the different specialists using bisphosphonates and by dental surgeons.
Oral surgery.
Maxillofacial surgery.
Dentistry.
Hematology.
General practice (Medicine).
Pharmacy.
Radiology.
Oral and Maxillofacial Surgery.
Dentistry.
Hematology.
General Practice / Family Medicine.
Pharmacy.
Imaging / Radiology.