Hand transplantation [electronic resource] /
Lanzetta, Marco.editor.
Dubernard, Jean-Michel.editor.
Transplanting a limb has been a dream of humanity - until 1998 when an international team of surgeons gathered in Lyon, France, and performed the first hand transplantation in history. Since then, groups in the United States, China, Austria, Italy and Belgium have launched hand transplantation programmes. In 2002, the International Registry on Hand and Composite Tissue Transplantation (IRHCTT) was created with the purpose of collecting and analysing data from every centre. This book presents the global experimental and clinical experience on hand transplantation and all types of other composite tissue allografts so far performed. A complete review of all aspects of these innovative and ground-breaking procedures is clearly presented in 15 different sections. They include the experimental basis of hand transplantation, strategies for selecting ideal candidates and preparing successful hand transplantation programmes, surgical techniques, most effective immunosuppressive drug regimes, analysis of the unique immunological behaviour of these transplants and rehabilitation protocols to achieve optimal sensory and motor recovery. Each section is dedicated to a special issue, such as psychological and medicolegal implications, brain remodelling after hand transplantation and introduction of a new scoring system for overall comprehensive outcome evaluation. A complete list of composite tissues allografts currently carried out around the world is reported in detail, including the face, abdominal wall, uterus, larynx and knee joint. This book is a milestone in the medical literature and represents a great asset for every scientific library.
Description based upon print version of record.
Includes bibliographical references and index.
Historical Remarks -- Cosmas and Damian Revisited -- Hand Transplantation as an Evolution of Microsurgery: A Logical Step Towards Better Reconstructive Options -- Experimental Limb Transplantation -- Hind-Limb Transplantation in the Rat: Surgical Technique, Anaesthesia and Early Postoperative Management -- Indefinite Survival and Functional Recovery of Limb Allografts in Rodents -- Induction of High-Level Chimerism in Composite Tissue Transplants -- Simultaneous Vascularised Bone Marrow Transplantation to Promote Acceptance of Limb Allografts -- Experimental Approaches to Composite Tissue Allograft Transplants -- A Review of Current Strategies to Achieve Tolerance in Animal Models -- The History of Experimental Hand Transplantation in Primates -- Hand Transplantation in Monkeys: Technical Details and Immunological Aspects -- Ethics and Medico-Legal Implications -- Ethical Aspects of Non-Life-Saving Allografts with Special Regard to the Hand -- Ethical Issues of Organ Transplantation in Non-Life-Saving Situations -- Informed Consent, Medico-Legal Implications, Public and Private Insurance Issues and Quantification of Disability in Hand Transplantation -- Living with Two Different Fingerprints: Legal Implications and Identification Issues -- Organization of Hand Transplantation -- Selection of Candidates and Waiting List, Dealing with the Media and the Public, Setting Up a Pilot Study, Clinical Trial Organization, Staff Requisites for Hand Transplantation: The Lyon Experience -- Selection of Candidates and Waiting List, Dealing with the Media and the Public, Setting Up a Pilot Study, Clinical Trial Organization, Staff Requisites for Hand Transplantation:The Milan Experience -- Selection of Candidates and Waiting List, Dealing with the Media and the Public, Setting Up a Pilot Study, Clinical Trial Organisation, Staff Requisites for Hand Transplantation: The Innsbruck Experience -- Selection of Candidates and Waiting List, Dealing with the Media and the Public, Setting Up a Pilot Study, Clinical Trial Organization, Staff Requisites for Hand Transplantation: The Brussels Experience -- Patient Management and Follow-up -- Surgical Technique of Hand Transplantation -- Instruments, Sutures and Needles for Hand Transplantation -- Anaesthetic Management -- Harvesting the Hand -- Preparing the Recipient -- Technical and Surgical Details of Hand Transplantation -- Hand Replantation and Transplantation: More Differences than Similarities -- Immunology of Hand Transplantation -- Current Concepts -- Immunosuppressive Therapy -- Induction and Maintenance Therapy -- Side-Effects and Potential Complications -- CMV Infection and Reactivation -- Specific T-Cell Response to HCMV Infection -- Ocular Complications after Hand Transplantation -- Limb Rejection and Monitoring -- Skin Rejection in Human Hand Allografts: Histological Findings and Grading System -- Pharmacological Treatment of Rejection -- Monitoring Rejection with a Distant Sentinel Skin Graft -- Functional Recovery of Transplanted Hands -- Bone Healing in Hand Transplantation -- Return of Sensibility and Motor Recovery of Extrinsic and Intrinsic Muscles -- From Silent Neuroma to Reactivation of Axonal Growth: How a Peripheral Nerve can Start to Regenerate into a Transplanted Hand? -- Modified Visual Feedback in Rehabilitation -- Analysis of Motor Unit Reinnervation in Muscles of the Transplanted Hand -- Role of the Sympathetic Nervous System on Arterial Distensibility -- An Instrumental Kit for a Comprehensive Assessment of Functional Recovery -- Human Brain Plasticity after Bilateral Hand Allograft -- The Sensor Glove in Preoperative Conditioning and Postoperative Rehabilitation -- A Comprehensive Functional Score System in Hand Transplantation -- Quality of Life in Hand Transplant Patients -- Psychological Issues in Hand Transplantation -- Psychological Evaluation and Patient's Profile -- Hand Transplant and Body Image -- Psychological Effects of Hand Transplantation -- Other Composite Tissue Transplant -- Allogeneic Vascularised Knee Transplantation -- Laryngeal Transplantation -- Uterus Transplantation -- Abdominal Wall Transplantation: A Review of the Literature -- First Human Face Allograft: Report at 4 months -- Lower-Extremity Hindquarter Transplantation in Conjoined Twins -- Future Directions -- Limb Transplantation in Congenital Deformities -- Mechanisms Involved in the Induction of Tolerance in Allogeneic Hand Transplantation: A Proposal -- Induction of Tolerance in Allotransplantation -- The International Registry on Hand and Composite Tissue Transplantation (IRHCTT) -- The International Registry on Hand and Composite Tissue Transplantation (IRHCTT) -- An Extensive Bibliography on Hand Transplantation -- An Extensive Bibliography on Hand Transplantation.
Transplanting a limb has been a dream of humanity - until 1998 when an international team of surgeons gathered in Lyon, France, and performed the first hand transplantation in history. Since then, groups in the United States, China, Austria, Italy and Belgium have launched hand transplantation programmes. In 2002, the International Registry on Hand and Composite Tissue Transplantation (IRHCTT) was created with the purpose of collecting and analysing data from every centre. This book presents the global experimental and clinical experience on hand transplantation and all types of other composite tissue allografts so far performed. A complete review of all aspects of these innovative and ground-breaking procedures is clearly presented in 15 different sections. They include the experimental basis of hand transplantation, strategies for selecting ideal candidates and preparing successful hand transplantation programmes, surgical techniques, most effective immunosuppressive drug regimes, analysis of the unique immunological behaviour of these transplants and rehabilitation protocols to achieve optimal sensory and motor recovery. Each section is dedicated to a special issue, such as psychological and medicolegal implications, brain remodelling after hand transplantation and introduction of a new scoring system for overall comprehensive outcome evaluation. A complete list of composite tissues allografts currently carried out around the world is reported in detail, including the face, abdominal wall, uterus, larynx and knee joint. This book is a milestone in the medical literature and represents a great asset for every scientific library.
Orthopedics.
Immunology.
Rehabilitation.
Surgery.
Plastic surgery.
Surgical transplantation.
Surgical Orthopedics.
Immunology.
Rehabilitation.
Surgery.
Plastic Surgery.
Transplant Surgery.