Biomaterials as Stem Cell Niche [electronic resource] /
Roy, Krishnendu.editor.
Recent developments in stem cell biology have opened new directions in cell therapy. This book provides the state-of-the-art developments in using biomaterials as artificial niches for engineering stem cells, both for the purpose of better understanding their biology under 3D biomimetic conditions as well as for developing new strategies for efficient long term maintenance and directed differentiation of stem cells into various therapeutic lineages. Animal and human stem cells of both embryonic and adult origin are discussed with applications ranging from nerve regeneration, orthopedics, cardiovascular therapy, blood cell generation and cancer therapy. Both synthetic and natural biomaterials are reviewed with emphasis on how material-stem cell interactions direct specific signaling pathways and ultimately modulate the cell fate. This book is valuable for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells.
Description based upon print version of record.
Biomaterials as Stem Cell Niche; Preface; Contents; Engineering ECM Complexity into Biomaterials for Directing Cell Fate; Functional Biomaterials for Controlling Stem Cell Differentiation; Integration of Biomaterials into 3D Stem Cell Microenvironments; Stem Cell Interaction with Topography; The Nanofiber Matrix as an Artificial Stem Cell Niche; Micropatterned Hydrogels for Stem Cell Culture; Microengineering Approach for Directing Embryonic Stem Cell Differentiation; Biomaterials as Stem Cell Niche: Cardiovascular Stem Cells
The Integrated Role of Biomaterials and Stem Cells in Vascular RegenerationSynthetic Niches for Stem Cell Differentiation into T cells; Understanding Hypoxic Environments: Biomaterials Approaches to Neural Stabilization and Regeneration after Ischemia; Biomaterial Applications in the Adult Skeletal Muscle Satellite Cell Niche: Deliberate Control of Muscle Stem Cells and Muscle Regeneration in the Aged Niche; Author Index
Includes bibliographical references and index.
Recent developments in stem cell biology have opened new directions in cell therapy. This book provides the state-of-the-art developments in using biomaterials as artificial niches for engineering stem cells, both for the purpose of better understanding their biology under 3D biomimetic conditions as well as for developing new strategies for efficient long term maintenance and directed differentiation of stem cells into various therapeutic lineages. Animal and human stem cells of both embryonic and adult origin are discussed with applications ranging from nerve regeneration, orthopedics, cardiovascular therapy, blood cell generation and cancer therapy. Both synthetic and natural biomaterials are reviewed with emphasis on how material-stem cell interactions direct specific signaling pathways and ultimately modulate the cell fate. This book is valuable for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells.
Biomedical engineering.
Stem cells.
Biomaterials.
Human genetics.
Medical biochemistry.
Biomedical Engineering and Bioengineering.
Stem Cells.
Biomaterials.
Human Genetics.
Medical Biochemistry.
Studies in Mechanobiology, Tissue Engineering and Biomaterials