Adrenocortical Carcinoma [electronic resource] : Basic Science and Clinical Concepts /
Hammer, Gary D.editor.
Else, Tobias.editor.
This first edition of the textbook “Adrenocortical Carcinoma: Basic Sciences and Clinical Concepts” provides a concise compilation of relevant data advancing our current understanding of this rare cancer. Chapters are dedicated to various aspects of both the basic biology and the clinical science relating to adrenocortical carcinoma (ACC). Expert clinicians introduce the reader to current state-of-the-art clinical care of patients with ACC. As a considerable body of knowledge on ACC has accumulated over the last decades, expert scientists have authored additional sections that serve as a reference source for the experienced researcher as well as an introduction for the trainee in the laboratory or clinic. Clinical topics span the epidemiology, diagnosis and therapy of ACC. Scientific topics areas span the pathology and pathophysiology of ACC with a special focus on experimental models of adrenocortical tumors and recent advances in the genetic aspects and signaling pathways in ACC. The content of this book was compiled and edited with the intent of facilitating the translation of knowledge into future diagnostic and therapeutic tools that will ultimately improve patient care.
Description based upon print version of record.
Preface; Contents; Contributors; Part I History of Adrenocortical Carcinoma Research and Clinical Care; 1 The History of Adrenocortical Carcinoma Treatment A Medical Perspective; 2 The History of Adrenocortical Carcinoma Treatment A Surgical Perspective; Part II Epidemiology, Presentation and Diagnosis; 3 Epidemiology of Adrenocortical Carcinoma; 4 Clinical Presentation and Initial Diagnosis; 5 Diagnostic Approach to Incidentaloma; Part III Imaging; 6 Computed Tomography/Magnetic Resonance Imaging of Adrenocortical Carcinoma; 7 Functional Imaging of Adrenocortical Carcinoma; Part IV Pathology
8 Classical Histopathology and Immunohistochemistry9 Cellular and Molecular Pathology of Adrenocortical Carcinoma; Part V Genetic and Molecular Aspects; 10 Overview of Genetic Syndromes Associated with Adrenocortical Cancer; 11 LiFraumeni Syndrome; 12 TP53 Molecular Genetics; 13 Telomeres and Telomerase in Adrenocortical Carcinoma; 14 Beckwith--Wiedemann Syndrome; 15 The Insulin-Like Growth Factor System in Adrenocortical Growth Control and Carcinogenesis; 16 WNT/-Catenin Signaling in Adrenocortical Carcinoma; Part VI Models of Adrenocortical Cancer
17 Adrenocortical Stem and Progenitor Cells: Implications for Cancer18 Adrenocortical Cell Lines; 19 Mouse Models of Adrenal Tumorigenesis; Part VII Therapies; 20 Overview of Treatment Options for Adrenocortical Carcinoma; 21 Chemotherapy; 22 Mitotane; 23 Pharmacotherapy for Hormone Excess in AdrenocorticalCarcinoma; 24 Surgery for Adrenocortical Carcinoma; 25 Radiation Therapy for Adrenocortical Carcinoma; 26 Follow-Up and Monitoring of Adrenocortical Carcinoma; Part VIII Unique Cohorts and Future Perspectives; 27 Aldosterone-Producing Adrenocortical Carcinoma
28 Adrenocortical Cancer in Children29 Genome-Wide Studies in Adrenocortical Neoplasia; 30 New Strategies for the Treatment of Adrenocortical Carcinoma; Part IX Adrenal Cancer Networks and Registries; 31 The Dutch Adrenal Network; 32 The ENS@T Initiative; Index
Includes bibliographical references and index.
This first edition of the textbook “Adrenocortical Carcinoma: Basic Sciences and Clinical Concepts” provides a concise compilation of relevant data advancing our current understanding of this rare cancer. Chapters are dedicated to various aspects of both the basic biology and the clinical science relating to adrenocortical carcinoma (ACC). Expert clinicians introduce the reader to current state-of-the-art clinical care of patients with ACC. As a considerable body of knowledge on ACC has accumulated over the last decades, expert scientists have authored additional sections that serve as a reference source for the experienced researcher as well as an introduction for the trainee in the laboratory or clinic. Clinical topics span the epidemiology, diagnosis and therapy of ACC. Scientific topics areas span the pathology and pathophysiology of ACC with a special focus on experimental models of adrenocortical tumors and recent advances in the genetic aspects and signaling pathways in ACC. The content of this book was compiled and edited with the intent of facilitating the translation of knowledge into future diagnostic and therapeutic tools that will ultimately improve patient care.
Cancer research.
Pharmacology.
Cancer Research.
Pharmacology/Toxicology.