Microbial Biochemistry [electronic resource] /
Cohen, G.N.author.
Microbial physiology, biochemistry, and genetics allowed the formulation of concepts that turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book. Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation. The next fifteen chapters deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12. The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle. The level of readership presupposes some knowledge of chemistry and genetics at the undergraduate level. The target group is graduate students, researchers in academia and industry.
Description based upon print version of record.
""Microbial Biochemistry""; ""Foreword""; ""Contents""; ""Abbreviations""; ""Introduction""; ""Chapter 1: Bacterial Growth""; ""Chapter 2: The Outer Membrane of Gram-negative Bacteria and the Cytoplasmic Membrane""; ""Chapter 3: Peptidoglycan Synthesis and Cell Division""; ""Chapter 4: Cellular Permeability""; ""Chapter 5: Allosteric Enzymes""; ""Chapter 6: Glycolysis, Gluconeogenesis and Glycogen Synthesis""; ""Chapter 7: The Pentose Phosphate and Entner-Doudoroff Pathways""; ""Chapter 8: The Tricarboxylic Acid Cycle and the Glyoxylate Bypass""
""Chapter 9: ATP-Generating Processes: Respiration and Fermentation""""Chapter 10: Biosynthesis of Lipids""; ""Chapter 11: Iron-Sulfur Proteins""; ""Chapter 12: The Archaea""; ""Chapter 13: Methanogens and Methylotrophs""; ""Chapter 14: Enzyme Induction in Catabolic Systems""; ""Chapter 15: Transcription: RNA Polymerase""; ""Chapter 16: Negative Regulation""; ""Chapter 17: Enzyme Repression in Anabolic Pathways""; ""Chapter 18: Positive Regulation""; ""Chapter 19: The Ribosomes""; ""Chapter 20: The Genetic Code, the Transfer RNAs and the Aminoacyl-tRNA-Synthetases""
""Chapter 21: Attenuation""""Chapter 22: Riboswitches""; ""Chapter 23: The Biological Fixation of Nitrogen""; ""Chapter 24: How Biosynthetic Pathways have been Established""; ""Chapter 25: The Aspartic Acid Family of Amino Acids: Biosynthesis""; ""Chapter 26: Regulation of the Biosynthesis of the Amino Acids of the Aspartic Acid Family in Enterobacteriacea""; ""Chapter 27: Other Patterns of Regulation of the Synthesis of Amino Acids of the Aspartate Family""; ""Chapter 28: Biosynthesis of the Amino Acids of the Glutamic Acid Family and Its Regulation""
""Chapter 29: Biosynthesis of Amino Acids Derived from Phosphoglyceric Acid and Pyruvic Acid""""Chapter 30: Selenocysteine and Selenoproteins""; ""Chapter 31: Biosynthesis of Aromatic Amino Acids and Its Regulation""; ""Chapter 32: The Biosynthesis of Histidine and Its Regulation""; ""Chapter 33: The Biosynthesis of Nucleotides""; ""Chapter 34: The Biosynthesis of Deoxyribonucleotides""; ""Chapter 35: Biosynthesis of Some Water-Soluble Vitamins and of Their Coenzyme Forms""; ""Chapter 36: Biosynthesis of Carotene, Vitamin A, Sterols, Ubiquinones and Menaquinones""
""Chapter 37: Biosynthesis of the Tetrapyrrole Ring System""""Chapter 38: Biosynthesis of Cobalamins Including Vitamin B12""; ""Chapter 39: Interactions Between Proteins and DNA""; ""Chapter 40: Evolution of Biosynthetic Pathways""; ""Index""
Includes bibliographical references and index.
Microbial physiology, biochemistry, and genetics allowed the formulation of concepts that turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book. Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation. The next fifteen chapters deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12. The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle. The level of readership presupposes some knowledge of chemistry and genetics at the undergraduate level. The target group is graduate students, researchers in academia and industry.
Molecular biology.
Microbiology.
Cell membranes .
Microbial genetics.
Microbial genomics.
Medical microbiology.
Molecular Medicine.
Microbiology.
Membrane Biology.
Microbial Genetics and Genomics.
Medical Microbiology.