Epidemiological and Molecular Aspects on Cholera [electronic resource] /
Ramamurthy, T.editor.
Bhattacharya, S.K.editor.
Though cholera is an ancient disease, its perennial occurrence in several parts of the world has attracted many researches to find ways and means to combat the disease. The prevailing seventh pandemic cholera is dominating since 1961, but the dimension of the disease has taken several silhouettes, as the genetic structure and functions of the Vibrio cholerae has changed to a great extent. Several recent studies have shown that transformation of the pathogen at the molecular level has ameliorated several cholera outbreaks and epidemics of with successive new clones of V. cholerae. This comprehensive compilation, written by eminent international researchers reviews the epidemiology of cholera in Africa, Asia, Russia and Latin Americas. The other chapters contributed by acclaimed authors cover various aspects on evolution, polysaccaharide biosynthesis, SXT element, integrons, small molecule signalling systems, flagellar synthesis, filamentous phages, pathogenic role of proteases and hemolysin, and other putative virulence factors. In addition, ecology of V. cholerae and management of cholera were also discussed in detail. This book will be good source of information to all researchers with interests in infectious diseases, microbiology and molecular biology.
Description based upon print version of record.
Preface; Contents; Contributors; 1 General Introduction; 2 Asiatic Cholera: Mole Hills and Mountains; 2.1 Introduction; 2.2 Cholera in the Indian Subcontinent; 2.3 Other Asian Countries; 2.4 Association Between V. cholerae and Parasites; 2.5 The O139 Cholera; 2.6 Antimicrobial Resistance; 2.7 Phage Typing of V. cholerae O1 and O139; 2.8 Molecular Epidemiology; 2.9 Seroepidemiology; 2.10 Prospects of Cholera Vaccines in Asia; 2.11 Traditional Medicine and Food Habits for Prevention of Cholera; 2.12 Control Measures and Health-Care Systems; 2.13 Conclusion; References
3 Endemic and Epidemic Cholera in Africa3.1 Introduction; 3.2 Epidemics and Outbreaks; 3.3 Risk Factors and Modes of Transmission of Cholera; 3.4 The Organism; 3.5 Seroepidemiology; 3.6 Use of Antimicrobials; 3.7 Molecular Findings; 3.8 Strategies to Curtail Cholera Outbreaks; 3.9 Conclusions; References; 4 Phenotypic and Molecular Characteristics of Epidemic and Non-epidemic Vibrio cholerae Strains Isolated in Russia and Certain Countriesof Commonwealth of Independent States (CIS); 4.1 Introduction; 4.2 Toxigenic (CTXφ+) V. cholerae Strains; 4.2.1 O1 Serogroup; 4.2.1.1 Classical Strains
4.2.1.2 El Tor Strains4.2.2 O139 Strains; 4.2.3 CTXφ+ Non-O1, Non-O139 Strains; 4.3 Non-choleragenic Strains; 4.3.1 Pre-CTXφ+ O1 and Non-O1, Non-O139 Strains; 4.3.2 CTXφτ̔̈““»“·/Pre-CTXφτ̔̈““»“· O1 Strains; 4.3.3 CTXφτ̔̈““»“·/Pre-CTXφτ̔̈““»“· Non-O1, Non-O139 Strains; 4.4 Environmental Strains: Harmless Refugees or Ambushing Bandits?; 4.5 Conclusions; References; 5 The Re-emergence of Cholera in the Americas; 5.1 Introduction; 5.2 Epidemiology of Cholera in Americas; 5.3 The Environmental Aspects of Cholera; 5.4 Management of Cholera and Other Related Diarrheal Infections; 5.5 Molecular Characterization of V. cholerae
5.6 Vibrio cholerae Non-O1 Associated with Cholera-RelatedDiarrheaReferences; 6 The Evolution of Vibrio cholerae as a Pathogen; 6.1 Introduction; 6.2 Pathogenesis; 6.3 Emergence of Endemic and Pandemic Vibrio cholerae; 6.4 Horizontal Transfer of Vibrio cholerae Virulence Genes; 6.5 Reactogenicity of Nontoxigenic Vaccine Prototypes in Humans; 6.6 The Discovery of Zot and Ace; 6.7 Other Toxins and Virulence Loci in the Evolution of Vibrio cholerae; 6.8 Conclusion; References; 7 Molecular Epidemiology of Toxigenic Vibrio cholerae; 7.1 Introduction; 7.2 Epidemiology of Cholera: Overview
7.3 Molecular Epidemiological Tools7.4 Molecular Epidemiology of Cholera; 7.4.1 Clonal Diversity of Epidemic Strains in Bangladesh and India; 7.4.2 Changing Antibiotic Resistance Among Toxigenic Vibrio cholerae; 7.5 Molecular Basis for Clonal Diversity; 7.6 Influence of Clonal Diversity on the Epidemiology of Cholera; References; 8 Diversity and Genetic Basis of Polysaccharide Biosynthesis in Vibrio cholerae; 8.1 Introduction; 8.2 Lipopolysaccharide (LPS); 8.2.1 Lipid A; 8.2.1.1 Composition and Structure of Lipid A; 8.2.1.2 Genetics of Lipid A Biosynthesis; 8.2.2 Core Oligosaccharide
8.2.2.1 Composition and Structure of Core Oligosaccharide
Includes bibliographical references and index.
Though cholera is an ancient disease, its perennial occurrence in several parts of the world has attracted many researches to find ways and means to combat the disease. The prevailing seventh pandemic cholera is dominating since 1961, but the dimension of the disease has taken several silhouettes, as the genetic structure and functions of the Vibrio cholerae has changed to a great extent. Several recent studies have shown that transformation of the pathogen at the molecular level has ameliorated several cholera outbreaks and epidemics of with successive new clones of V. cholerae. This comprehensive compilation, written by eminent international researchers reviews the epidemiology of cholera in Africa, Asia, Russia and Latin Americas. The other chapters contributed by acclaimed authors cover various aspects on evolution, polysaccaharide biosynthesis, SXT element, integrons, small molecule signalling systems, flagellar synthesis, filamentous phages, pathogenic role of proteases and hemolysin, and other putative virulence factors. In addition, ecology of V. cholerae and management of cholera were also discussed in detail. This book will be good source of information to all researchers with interests in infectious diseases, microbiology and molecular biology.
Infectious diseases.
Microbiology.
Infectious Diseases.
Microbiology.
Infectious Disease