Epigenetic Regulation of Lymphocyte Development [electronic resource] /
Murre, Cornelis.editor.
Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
Description based upon print version of record.
""Epigenetic Regulation of Lymphocyte Development""; ""Preface""; ""Contents""; ""Contributors""; ""142 Roles of Lineage-Determining Transcription Factors in Establishing Open Chromatin: Lessons From  High-Throughput Studies""; ""Abstract""; ""1â€?Introduction""; ""2â€?Transcription Factors Co-Localize in a Cell Type-Specific Manner""; ""3â€?Transcription Factors Collaborate to Gain Access  to Chromatinized DNA on a Genome-Wide Scale""; ""3.1 Ternary Complex Formation Plays a Minor Role in Defining Genome-Wide Transcription Factor Binding Patterns""; ""3.1.1 A Case for Chromatin""
""3.1.2 Pioneer Factors Collaborate to Access the Chromatinized Genome""""3.1.3 Genome-Wide Data Supports a Collaborative Mechanism of Transcription Factor Binding Patterning""; ""3.1.4 Transcription Factor Concentrations Define the Joint Binding Pattern""; ""4â€?Lineage-Determining Transcription Factors Prime Lineage-Specific Cis-Regulatory Modules""; ""4.1 A Two-Tiered System of Transcription Factors?""; ""4.1.1 Lineage-Determining Factors Induce Histone H3K4 Mono-and  Di-Methylation Surrounding Their Binding Sites""; ""4.1.2 Mechanistic Notes""
""4.1.3 Signal-Dependent Transcription Factors Act on Primed CREs""""5â€?Implications for Cellular Development and Reprogramming""; ""5.1 Putting it All Together""; ""5.2 Epigenomics as a Means to Identify the Factors Necessary for Cellular Reprogramming?""; ""5.2.1 Outlook""; ""References""; ""139 B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1""; ""Abstract""; ""1â€?Prologue""; ""2â€?Introduction""; ""3â€?Early B Cell Factor 1: Protein Structure and Function""; ""3.1 Early Studies of EBF1""
""3.2 X-ray Crystallographic Analysis of EBF1 Structure""""3.3 Structures of Other Domains in EBF1""; ""4â€?Control of B Lymphopoiesis Requires a Network  of Proteins Including EBF1""; ""4.1 EBF1 and the Basis of B Lineage Fate Decisions""; ""4.2 Effects of Changes in Ebf1 Gene Dosage on B Cell Development""; ""4.3 EBF1 and B Cell Lineage Commitment""; ""5â€?Identification of EBF1 Target Genes Using  Genome-Wide Analysis""; ""5.1 Binding of EBF1 to a Vast Array of Sites in Pro-B Cells""; ""5.2 Co-occupancy of Genes by EBF1 and E2A""; ""5.3 Epigenetic Regulation of Genes by EBF1""
""5.4 Multiple Mechanisms Activate Cd79a Transcription  in Early B Cells""""6â€?Conclusions""; ""Acknowledgments""; ""References""; ""153 Epigenetic Features that Regulate IgH Locus Recombination and Expression""; ""Abstract""; ""1â€?Overview of the Immunoglobulin Heavy Chain Genomic Organization""; ""2â€?The First Step of IgH Gene Assembly: DH to JH Recombination""; ""2.1 Features of DH to JH Recombination""; ""2.2 Regulation of DH Recombination""; ""2.3 Epigenetic Features of the DH--C mu Domain""; ""2.4 Chromosome Conformation of the DH--C mu Domain""
""2.5 Functional Implications of the Structure  of the 3vprime IgH Domain""
Includes bibliographical references and index.
Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
Immunology.
Gene expression.
Immunology.
Gene Expression.
Current topics in microbiology and immunology