Cardiovascular Disease in AIDS [electronic resource] /
Barbaro, Giuseppe.editor.
Boccara, Franck.editor.
The introduction of highly active antiretroviral therapy (HAART) has significantly improved the clinical outcome of HIV disease with increased survival rates. However, the introduction of HAART has generated a contrast in the cardiac manifestations of AIDS. In developed countries, we observed an approximate 30% reduction in the prevalence of HIV-associated cardiomyopathy, possibly related to a reduction of opportunistic infections and myocarditis. In developing countries, however, where the availablity of HAART is limited and the pathogenic impact of nutritional factors is significant, we observed an approximate 32% increase in the prevalence of HIV-associated cardiomyopathy and a related high mortality rate from congestive heart failure. Also, some HAART regimens in developed countries, especially those including protease inhibitors, may cause a iatrogenic metabolic syndrome (HIV-lipodystrophy syndrome) that is associated with an increased risk of cardiovascular disease. At the same time, the relapse of some oppurtunistic infections, with possible myocardial involvement, in HIV-infected patients receiving HAART, in the context of the recently described immune reconstitution inflammatory syndrome, yielded an intriguing and complex profile of this double face of cardiology in AIDS in the HAART era. In this new edition of Cardiovascular Disease in AIDS new insights coming from basic and clinical research in the field of HIV-associated cardiovascular disease and antiretroviral therapy are reported, along with the clinical guidelines for a careful stratification of the cardiovascular risk and cardiovascular monitoring of HIV-infected patients receiving HAART. The authors offer a wide overview of the topic for specialists in cardiology and infectious diseases involved in the clinical management of HIV-infected patients.
Description based upon print version of record.
Includes bibliographical references and index.
Evolution and Pathogenesis of the Involvement of the Cardiovascular System in HIV Infection -- Pathogenesis of HAART-Associated Metabolic Syndrome -- Pathology of Cardiac Complications in HIV Infection -- Pathology of Peripheral and Coronary Vessels in AIDS Patients -- Coronary Heart Disease in HIV-Infected Patients: Epidemiology -- Coronary Artery Disease in HIV-Infected Patients: Clinical Presentation, Pathophysiology, Prognosis, Prevention, and Treatment -- Cerebrovascular Disease in HIV-Infected Patients -- Peripheral Arterial Disease in HIV-Infected Patients: Atherosclerosis and Vasculitic Syndromes -- HIV-Associated Pulmonary Hypertension -- Coagulative Disorders in HIV-Infected Patients -- Cardiovascular Complications in HIV-Infected Children -- Cardiac Surgery and the Human Immunodeficiency Virus -- Cardiological Emergencies in HIV-Infected Patients -- Guidelines for the Prevention of Cardiovascular Risk in HIV-Infected Patients Treated with Antiretroviral Drugs.
The introduction of highly active antiretroviral therapy (HAART) has significantly improved the clinical outcome of HIV disease with increased survival rates. However, the introduction of HAART has generated a contrast in the cardiac manifestations of AIDS. In developed countries, we observed an approximate 30% reduction in the prevalence of HIV-associated cardiomyopathy, possibly related to a reduction of opportunistic infections and myocarditis. In developing countries, however, where the availablity of HAART is limited and the pathogenic impact of nutritional factors is significant, we observed an approximate 32% increase in the prevalence of HIV-associated cardiomyopathy and a related high mortality rate from congestive heart failure. Also, some HAART regimens in developed countries, especially those including protease inhibitors, may cause a iatrogenic metabolic syndrome (HIV-lipodystrophy syndrome) that is associated with an increased risk of cardiovascular disease. At the same time, the relapse of some oppurtunistic infections, with possible myocardial involvement, in HIV-infected patients receiving HAART, in the context of the recently described immune reconstitution inflammatory syndrome, yielded an intriguing and complex profile of this double face of cardiology in AIDS in the HAART era. In this new edition of Cardiovascular Disease in AIDS new insights coming from basic and clinical research in the field of HIV-associated cardiovascular disease and antiretroviral therapy are reported, along with the clinical guidelines for a careful stratification of the cardiovascular risk and cardiovascular monitoring of HIV-infected patients receiving HAART. The authors offer a wide overview of the topic for specialists in cardiology and infectious diseases involved in the clinical management of HIV-infected patients.
Cardiology.
Internal medicine.
Infectious diseases.
Neurology .
Cardiac surgery.
Cardiology.
Internal Medicine.
Infectious Diseases.
Neurology.
Cardiac Surgery.