Malignant Effusions [electronic resource] : Pleuritis, Ascites, Pericardites /
Kiselevsky, Mikhail V.editor.
Malignant effusions (pleurites, ascites and pericardites) are some of the most frequent manifestations of dissemination process of malignant tumors. Accumulation of the malignant fluid in serous cavities results in impairment of respiratory and cardiac functions, however long-term evacuation of the fluid leads to severe disorders of homeostasis that may directly cause the patient’s death.  The aim of this comprehensive book is to provide detailed information of pathogenesis and management of malignant effusions. The current book focuses on three of these categories: pleuritis, acsites and pericarditis. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject. The presented book reports valuable information about malignant effusions to basic and clinical medical specialists in academia, practice, as well as industry. The main topics considered include contemporary diagnostic approaches and modern therapeutic strategies, including conventional drugs, methods of intracavitary adoptive immunotherapy, chemotherapy and hyperthermia, commercial and experimental drugs being still under study. The material is presented in an easy to read and understandable language and uses a plethora of tables and figures. This book is aimed at oncologists, as well as phthisiatricians, surgeons, therapists and physicians of various specializations, who have to make diagnosis and treat effusions during their professional activity, and it will be undoubtedly helpful for interns, post-graduates and Ph.D. fellows of medical centers.
Description based upon print version of record.
Malignant Effusions; Preface; Contents; Contributors; Chapter 1: Morphological and Functional Characteristics of Serous Cavities; 1.1 Pleural Cavity; 1.2 Peritoneum (Abdominal Cavity); 1.3 Pericardium; 1.4 Conclusion; References; Chapter 2: Pathogenesis of Malignant Effusions; 2.1 Pathogenesis of Pleural Effusion; 2.2 Pathogenesis of Ascites; 2.3 Pathogenesis of Pericardites; 2.4 Conclusion; References; Chapter 3: Diagnosis and Treatment of Malignant Pleural Effusion; 3.1 Introduction; 3.2 Epidemiology; 3.3 Aetiology and Pathogenesis; 3.4 Diagnosis; 3.4.1 Non-Invasive Diagnostic Methods
3.4.1.1 History and Physical Examination3.4.1.2 Imaging Techniques; Chest X-Rays; Ultrasounds; Computerized Tomography (CT); PET Scan; 3.4.1.3 Tumour Markers; 3.4.2 Invasive Techniques; 3.4.2.1 Thoracentesis; Cell Count; Chemical Analysis; Cytology; 3.4.2.2 Percutaneous Needle Biopsy; 3.4.2.3 Thoracoscopy; Medical Thoracoscopy (MT); Video-Assisted Thoracoscopic Surgery (VATS); 3.4.2.4 Thoracotomy; 3.4.3 Diagnosis Algorithm; 3.5 Treatment; 3.5.1 General Measures; 3.5.1.1 Observation; 3.5.1.2 Therapeutic Pleural Aspiration; 3.5.2 Pleurodesis; 3.5.2.1 Introduction
3.5.2.2 Choice of Sclerosing AgentTalc; Bleomycin; Tetracycline (Doxycycline); Other Agents; 3.5.2.3 Techniques for the Application of Sclerosing Agents; Pleurodesis with Aerosolized Talc (Talc Poudrage) Under Thoracoscopy; Pleurodesis with Talc Suspension (Talc Slurry); 3.5.2.4 Prognostic Factors for Successful Pleurodesis; Sex of the Patient; Karnofsky Performance Score (KPS); Tumour Type; pH of Pleural Fluid; ADA Levels in Pleural Fluid; The Neutrophilic and Fibrinolytic Response; Activation of Systemic Coagulation; Technique; Size of Chest Tube
Duration of Pleural Drainage After Pleurodesis3.5.3 Chronic Indwelling Catheter; 3.5.4 Pleurectomy; 3.5.4.1 Special Case of Malignant Pleural Mesothelioma (MPM); 3.5.5 Systemic Chemotherapy, Radiotherapy and Intrapleural Chemotherapy; 3.5.6 Special Circumstances: Treatment of Trapped Lung; 3.5.7 Treatment Algorithm; 3.6 Conclusions; References; Chapter 4: Malignant Ascites: Diagnosis and Treatment; 4.1 Introduction; 4.2 Epidemiology of Malignant Ascites; 4.3 Diagnosis; 4.4 Medical Treatment of Malignant Ascites; 4.4.1 Symptomatic Treatment: Diuretics, Paracentesis and Shunts
4.4.2 Intraperitoneal (IP) or Systemic Chemotherapy4.4.3 Intraperitoneal Hyperthermic Chemotherapy (HIPEC) Alone or in Combination with Cytoreductive Surgery; 4.4.4 Cytokines and Other Immunotherapies; 4.4.5 Corticosteroids; 4.4.6 Biologic and Novel Agents; 4.4.6.1 Trifunctional Bispecific Antibodies; 4.4.6.2 Anti-VEGF Antibodies; 4.4.6.3 Matrix Metalloproteinase Inhibitors (MMPIs); 4.4.6.4 Somatostatin Analogues (Octreotide); 4.4.6.5 Radioisotopes; 4.4.6.6 Photodynamic Therapy; 4.4.6.7 Vaccines and Antibodies; 4.5 Conclusions; References; Chapter 5: Malignant Pericardial Disease
5.1 Introduction
Includes bibliographical references and index.
Malignant effusions (pleurites, ascites and pericardites) are some of the most frequent manifestations of dissemination process of malignant tumors. Accumulation of the malignant fluid in serous cavities results in impairment of respiratory and cardiac functions, however long-term evacuation of the fluid leads to severe disorders of homeostasis that may directly cause the patient’s death.  The aim of this comprehensive book is to provide detailed information of pathogenesis and management of malignant effusions. The current book focuses on three of these categories: pleuritis, acsites and pericarditis. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject. The presented book reports valuable information about malignant effusions to basic and clinical medical specialists in academia, practice, as well as industry. The main topics considered include contemporary diagnostic approaches and modern therapeutic strategies, including conventional drugs, methods of intracavitary adoptive immunotherapy, chemotherapy and hyperthermia, commercial and experimental drugs being still under study. The material is presented in an easy to read and understandable language and uses a plethora of tables and figures. This book is aimed at oncologists, as well as phthisiatricians, surgeons, therapists and physicians of various specializations, who have to make diagnosis and treat effusions during their professional activity, and it will be undoubtedly helpful for interns, post-graduates and Ph.D. fellows of medical centers.
Medicine.
Cancer research.
Oncology  .
Medical education.
Immunology.
Radiology.
Biomedicine, general.
Cancer Research.
Oncology.
Medical Education.
Immunology.
Imaging / Radiology.