Tumors of the Central Nervous System, Volume 8 [electronic resource] : Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma /
Hayat, M.A.editor.
With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma.                                                        Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targeted-and thus more effective.
Description based upon print version of record.
Tumors of the Central Nervous System; One Point of View; Overtreatment; References; Preface and Introduction, Volume 8: Tumors of the Central Nervous System; Contents; Contents of Volume 1; Contents of Volume 2; Contents of Volume 3; Contents of Volume 4; Contents of Volume 5; Contents of Volume 6; Contents of Volume 7; Contributors; Part I: Astrocytoma; 1: Astrocytoma Cell Line: Role of Brain Natriuretic Peptide; Introduction; Molecular Structures, Receptors, and Intracellular Signaling of Natriuretic Peptides; Expression, Receptor, and Function of NPS in the CNS
Expression and Release of NPS in Astrocytoma Cell Line and Glia CellsRole of NPS in Astrocytoma Cell Line and Glial Cell Physiology and Pathophysiology; Anti-apoptotic Effect; Anti-proliferative Effect; Neuron-Glia Communication; Regulation of Cerebral Blood Flow and Water Balance; Neuroinflammation; Neuroprotection; Conclusions; References; 2: Malignant Brain Astrocytomas: Extent of Resection Affects Survival; Introduction; Factors Associated with Survival; Extent of Resection and Survival; Studies on Malignant Astrocytomas and Extent of Resection
Limitation of Studies on Malignant AstrocytomasFindings on Malignant Astrocytomas and Extent of Resection; Modalities to Enhance Extent of Resection; Limitations of Extensive Resection; References; Part II: Medulloblastoma; 3: Medulloblastoma: Classification (A Review); Introduction; Historical Perspective; Classification of Medulloblastoma; Genetic and Molecular Profiles in the Classification of Medulloblastoma; Cytogenetic Aberrations; Molecular Genetic of Medulloblastoma; Other Pathways; Conclusion; References; 4: Medulloblastomas: Clinically Important MicroRNA Genes; Introduction
Pathological Classifications, Treatments and Prognoses Associated with MedulloblastomasMechanism of MicroRNA Biogenesis; MicroRNA Genes and Relevance to Cancers; Applications of MicroRNA Genes in Medulloblastomas; Use of MicroRNA Genes as Functional Biomarkers; Uses of MicroRNA Genes for Tumor Pathological Classi fi cations and Prognostic Applications; Use of MicroRNA Genes for Targeted Therapies; Novel Strategies in MicroRNA Gene Targeted Therapies; Concluding Remarks; References; 5: Medulloblastoma: Role of OTX2 Transcription Factors; Introduction; Developmental Role of OTX2
Ampli fi cation of OTX2 in MedulloblastomaClinical Presentation of Medulloblastoma; Targeting OTX2; Conclusion; References; 6: Molecular Mechanisms of Chemoresistance in Medulloblastoma; Introduction; Mechanisms of Resistance to DNA-Damaging Agents and DNA Repair Systems; Role of p53 and NF-KappaB Transcription Factors in Medulloblastoma Resistance and Relapse; Caspase-8 Re-activation in Medulloblastoma; Targeting PI3K and Beta-Catenin in Medulloblastoma; Multidrug Resistance and Cell Micro-environment; References; 7: Extraneural Metastasis in Medulloblastoma; Introduction
Mechanisms of Extraneural Spread
Includes bibliographical references and index.
With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma.                                                        Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targeted-and thus more effective.
Cancer research.
Oncology  .
Pathology.
Neurosciences.
Primary care (Medicine).
Cancer Research.
Oncology.
Pathology.
Neurosciences.
Primary Care Medicine.

Tumors of the central nervous system