Neurosteroids and the Nervous System [electronic resource] /
King, Steven R.author.
While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo ("neurosteroids"). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychologicalconditions and neurological diseases. This Brief will focus on the current state of understanding of brainderived neurosteroids.
Description based upon print version of record.
Neurosteroids and the Nervous System; Contents; Neurosteroids and the Nervous System; 1 Introduction; 2 Steroidogenic Enzymes in the Nervous System; 2.1 P450scc, StAR, and Neurosteroidogenesis; 2.2 Peripheral Benzodiazepine Receptor/TSPO; 2.3 StAR-Independent Steroidogenesis; 2.4 DHEA, Sulfotransferase (SULT), and Sulfated Steroids; 3 Regulation of De Novo Neurosteroidogenesis; 4 Steroidogenic Pathways; 5 Mechanism of Action of Neurosteroids; 5.1 GABA A and GABA r Receptors; 5.2 Glycine Receptors; 5.3 s Receptors; 5.3.1 s 1 Receptors; 5.3.2 PGRMC1 Receptors; 5.4 Ionotropic Glutamate Receptors
5.5 Transient Receptor Potential (TRP) Superfamily5.6 Membrane Estrogen Receptors; 5.7 Other Membrane Steroid Receptors; 5.8 Other Receptors; 6 Neurosteroid Functions; 7 Neuronal Growth, Synaptic Plasticity, and Brain Development; 7.1 Neurosteroid Production; 7.2 Functional Effects of Neurosteroids; 7.2.1 Progesterone, Testosterone, and Estradiol; 7.2.2 DHEA and DHEA-S; 7.2.3 Pregnenolone and Pregnenolone Sulfate; 7.2.4 Allopregnanolone; 8 Neurosteroids, Anxiety, and Psychiatric Disorders; 8.1 Anxiety and Stress; 8.1.1 3 a -Reduced Steroids Can Promote Anxiolysis
8.1.2 The Anxiogenic Effects of 3 a -Reduced Steroids in Puberty and a Model of Anorexia8.1.3 Estrogen, Progesterone, and Anxiety; 8.1.4 The Opposing Actions of DHEA, Pregnenolone, and Their Sulfate Conjugates in Anxiety; 8.1.5 The Roles of Neurosteroids in Other Models of Stress; 8.2 Therapeutic Synthetic Drugs Increase Neurosteroidogenesis; 8.3 Depression; 8.4 Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD); 8.5 HRT and Mood; 8.6 Other Psychiatric Disorders; 9 Neurosteroids and Cognition; 9.1 Promnesic Neurosteroids
9.1.1 Promnesic and Anti-amnesic Effects of DHEA-S and Pregnenolone Sulfate9.1.2 Estradiol; 9.2 Amnesic Neurosteroids; 9.2.1 Allopregnanolone; 9.2.2 Progesterone; 9.3 Age-Related Memory Changes and Neurosteroid Rescue; 9.3.1 The Cognitive Effects of HRT in Women; 10 Neurosteroids and Reproduction; 10.1 Female Reproduction; 10.1.1 Progesterone and the LH Surge; 10.1.2 Allopregnanolone Effects on GnRH and Gonadotropins; 10.2 Female Sexual Behavior; 10.2.1 Progesterone; 10.2.2 Allopregnanolone; 10.2.3 The Role of Steroids in Female Libido; 10.3 Male Reproduction; 10.4 Male Sexual Behavior
10.5 Male-Typical Behavior11 Sleep, Anesthesia, and Hypnotic Effects; 12 Other Functions; 13 Neurosteroids in Disease and Injury; 13.1 Neuroprotection in the Brain; 13.1.1 Progesterone and Allopregnanolone; 13.1.2 Pregnenolone Sulfate; 13.1.3 Estrogen; 13.1.4 Testosterone; 13.1.5 Protective Effects of HRT; 13.1.6 DHEA and DHEA-S; 13.2 Neurosteroids in Neurodegenerative Disorders in the Brain; 13.2.1 Alzheimer's Disease (AD); 13.2.2 HRT and AD; 14 Neurosteroids and Convulsant Activity; 14.1 Anticonvulsant Effects of Neurosteroids; 14.1.1 Protection Against Epileptogenesis
14.1.2 Seizures Related to Changes in Gonadal and Neural Steroids
Includes bibliographical references and index.
While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo ("neurosteroids"). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychologicalconditions and neurological diseases. This Brief will focus on the current state of understanding of brainderived neurosteroids.
Neurosciences.
Neurochemistry.
Neurosciences.
Neurochemistry.
SpringerBriefs in Neuroscience