Cellular Physiology and Metabolism of Physical Exercise [electronic resource] /
Luzi, Livio.editor.
The book covers areas of cellular physiology and metabolism that are of interest to scientists involved in research in diabetes and metabolic diseases. Some chapters of the book are specifically research-oriented, as all the authors are actively practicing either bench or clinical research in the area. Nonetheless, since the work is fully comprehensive of the discipline, it is also suitable for university classes of graduate and undergraduate students. In particular, the book discusses classical aspects of cellular physiology and the metabolism of physical exercise, as well as novel topics like exercise in transplantation and exercise in beta-cell failure, which mark the frontiers of research in sport-related sciences and research. Exercise physiologists, biologists and physicians are the specific professional and academic targets of this work. The team of authors together with the editor are world-renowned experts in the field of physiology and metabolism applied to sport sciences.
Description based upon print version of record.
Title Page; Copyright Page; Preface; About the Editor; Table of Contents; Contributors; 1 Human Evolution and Physical Exercise: The Concept of Being "Born to Run"; 1.1 The Concept of Being Born to Run; 1.2 From Five Billion to One Million Years Ago; 1.3 The Appearance of the Genus Homo; References; 2 Cell Morphology and Function: The Specificities of Muscle Cells; 2.1 Introduction; 2.2 Striated Skeletal Muscles; 2.3 Muscle Contraction; Suggested Reading; 3 The Cell Membrane of the Contractile Unit; 3.1 Cell Membranes; 3.2 The Structure of the Cell Membrane; 3.2.1 Lipids; 3.2.2 Proteins
3.2.3 Carbohydrates3.3 Functions of the Cell Membrane; 3.3.1 Transport; 3.3.2 Diffusion; 3.3.3 Facilitated Diffusion; 3.3.4 Active Transport; 3.3.5 Phagocytosis and Pinocytosis; 3.4 Immune System; 3.5 Membrane Receptors; 3.6 The Sarcolemma; References; 4 Gene Polymorphisms and Athletic Performance; 4.1 Introduction; 4.2 What Happens When the Balance in the Human Body Is Modified?; 4.3 Human Performance Shows a Wide Variety of Responses; 4.4 Can Genes Predict Athletic Performance?; 4.5 Genetic Variability Between Individuals
4.6 Genetic Polymorphisms of the Enzymes Involved in DNA Methylation and Synthesis in Elite AthletesSuggested Reading; 5 Nutrients and Whole-Body Energy Metabolism: The Impact of Physical Exercise; 5.1 Introduction; 5.2 Energy and ATP; 5.3 Nutrition and Athletic Performance; 5.4 Central Nervous System; 5.5 Leptin and Insulin; 5.6 Exercise; 5.7 Obesity; 5.8 Conclusions; References; 6 Mitochondrial and Non-mitochondrial Studies of ATP Synthesis; 6.1 Introduction; 6.2 In Vivo Magnetic Resonance Spectroscopy; 6.2.1 1H-MRS; 6.2.2 13C-MRS; 6.2.3 31P-MRS
6.3 Mitochondrial Function Assessed by 31P-MRS6.3.1 Mitochondrial Function During Exercise as Assessed by 31P-MRS; 6.4 Measurement of TCA Cycle Flux (VTCA); 6.5 Anaerobic Sources of ATP; 6.5.1 Glycolytic Flux; 6.5.2 PCr Breakdown; 6.5.3 Glycogen; 6.6 Integrative View; References; 7 Excessive Nutrients and Regional Energy Metabolism; 7.1 Introduction; 7.2 Excessive Ectopic Fat Accumulation and Abnormal Regulation of Insulin-Dependent Metabolic Pathways; 7.2.1 Skeletal Muscle; 7.2.2 Heart; 7.2.3 Liver
7.3 Excessive Ectopic Fat Accumulation as the Consequence of Increased Adipose-Derived FFA Flux7.4 The Association of Excessive Ectopic Fat Accumulation and Abnormalities of Energy Metabolism; 7.4.1 Skeletal Muscle; 7.4.2 Heart; 7.4.3 Liver; 7.5 Conclusion; References; 8 Muscle Biopsy To Investigate Mitochondrial Turnover; 8.1 Skeletal Muscle Biopsy; 8.2 Skeletal Muscle Function and Mitochondria; 8.3 Mitochondrial Glucose and Fatty Acid Oxidation; 8.4 Regulation of Mitochondrial Oxidative Metabolism; 8.4.1 Energy Status; 8.4.2 Exercise; 8.4.3 Nutrition; 8.4.3.1 Caloric Restriction
8.4.3.2 Fat and Glucose Substrates
Includes bibliographical references and index.
The book covers areas of cellular physiology and metabolism that are of interest to scientists involved in research in diabetes and metabolic diseases. Some chapters of the book are specifically research-oriented, as all the authors are actively practicing either bench or clinical research in the area. Nonetheless, since the work is fully comprehensive of the discipline, it is also suitable for university classes of graduate and undergraduate students. In particular, the book discusses classical aspects of cellular physiology and the metabolism of physical exercise, as well as novel topics like exercise in transplantation and exercise in beta-cell failure, which mark the frontiers of research in sport-related sciences and research. Exercise physiologists, biologists and physicians are the specific professional and academic targets of this work. The team of authors together with the editor are world-renowned experts in the field of physiology and metabolism applied to sport sciences.
Human physiology.
Molecular biology.
Diabetes.
Metabolism.
Cell biology.
Human Physiology.
Molecular Medicine.
Diabetes.
Metabolomics.
Cell Biology.